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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

MLLT11 Gene

protein-coding   GIFtS: 48
GCID: GC01P151030

myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog,...

 Explore 8 diseases affiliated with
MLLT11 via our new
 Human Malady Compendium 
Biological research products
for MLLT11
    

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section

Aliases
Myeloid/Lymphoid Or Mixed-Lineage Leukemia (Trithorax Homolog, Drosophila);
Translocated To, 111 2
AF1Q1 2 3 5
RP11-316M1.102
ALL1 Fused Gene From Chromosome 1q2
ALL1-Fused Gene From Chromosome 1q2
Protein AF1q2

External Ids:    HGNC: 169971   Entrez Gene: 109622   Ensembl: ENSG000002131907   OMIM: 6046845   UniProtKB: Q130153   

Export aliases for MLLT11 gene to outside databases

Previous GC identifers: GC01P147835 GC01P147845 GC01P149286 GC01P149298 GC01P122409


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for MLLT11:
The gene variously symbolized ALL1, HRX, or MLL located on 11q23 has been demonstrated to be fused with a number of
translocation partners in cases of leukemia. t(1;11)(q21;q23) translocations that fused the MLL gene to a gene on
chromosomal band 1q21 in 2 infants with acute myelomonocytic leukemia have been demonstrated. The N-terminal portion
of the MLL gene is critical for leukemogenesis in translocations involving band 11q23. This gene encodes 90 amino
acids. It was found to be highly expressed in the thymus but not in peripheral lymphoid tissues. In contrast to its
restricted distribution in normal hematopoietic tissue, this gene was expressed in all leukemic cell lines tested.
(provided by RefSeq, Jul 2008)




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000001.10  NC_018912.1  NT_004487.19  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the MLLT11 gene promoter:
         E2F-3a   E2F-4   NF-1   E2F-5   ATF-2   HSF1 (long)   E2F-2   E2F   E2F-1   HSF1short   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidMLLT11 promoter sequence
   Search SABiosciences Chromatin IP Primers for MLLT11

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat MLLT11


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1q21   Ensembl cytogenetic band:  1q21.3   HGNC cytogenetic band: 1q21

MLLT11 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
MLLT11 gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01P151030:  view genomic region     (about GC identifiers)

Start:
151,030,234 bp from pter      End:
151,040,973 bp from pter
Size:
10,740 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: AF1Q_HUMAN, Q13015 (See protein sequence)
Recommended Name: Protein AF1q  
Size: 90 amino acids; 10061 Da

Explore the universe of human proteins at neXtProt for MLLT11: NX_Q13015

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q13015

  • MLLT11 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins: NP_006809.1  
    ENSEMBL proteins: 
     ENSP00000357917  

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    Uscn Proteins for MLLT11

    Gene Ontology (GO): 1 cellular component term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005622intracellular IDA18852119


    MLLT11 for ontologies           About GeneDecksing



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    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    MLLT11 for domains           About GeneDecksing

    1 InterPro domain/family:
     IPR026778 MLLT11_fam

    Graphical View of Domain Structure for InterPro Entry Q13015

    ProtoNet protein and cluster: Q13015

    UniProtKB/Swiss-Prot: AF1Q_HUMAN, Q13015
    Similarity: Belongs to the MLLT11 family


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section

    miRNA
    Products:
        
    miRTarBase miRNAs that target MLLT11:
    hsa-mir-30a (MIRT005154), hsa-mir-16 (MIRT001441)

    OriGene 3'-UTR Clone: MLLT11
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    hsa-miR-3128 hsa-miR-136 hsa-miR-29c hsa-miR-29a hsa-miR-507 hsa-miR-339-5p hsa-miR-10b* hsa-miR-511
    SwitchGear 3'UTR luciferase reporter plasmidMLLT11 3' UTR sequence
    Inhib. RNA
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    Gene Ontology (GO): 1 molecular function term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003674molecular_function ND--


    MLLT11 for ontologies           About GeneDecksing



    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section



    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for MLLT11

    STRING Interaction Network Preview (showing 4 interactants - click image to see more details)

    5/6 Interacting proteins for MLLT11 (Q130153 ENSP000003579174) via UniProtKB, MINT, STRING, and/or I2D (see all 6)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    CAMKK2Q96RR43I2D: score=1 
    CLN3Q132863I2D: score=1 
    ADCY10ENSP000003568254STRING: ENSP00000356825
    RER1ENSP000003020884STRING: ENSP00000302088
    UBCENSP000003448184STRING: ENSP00000344818
    About this table

    Gene Ontology (GO): 5/6 biological process terms (GO ID links to tree view) (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0043065positive regulation of apoptotic process IMP18852119
    GO:0045893positive regulation of transcription, DNA-dependent IDA18852119
    GO:0051901positive regulation of mitochondrial depolarization IDA18852119
    GO:0090200positive regulation of release of cytochrome c from mitochondria IDA18852119
    GO:0097191extrinsic apoptotic signaling pathway IDA18852119


    MLLT11 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for MLLT11
    Search CenterWatch for drugs/clinical trials and news about MLLT11 / AF1Q 

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for MLLT11 gene: 
    NM_006818.3  

    Unigene Cluster for MLLT11:

    Myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 11
    Hs.75823  [show with all ESTs]
    Unigene Representative Sequence: BC022448
    1 Ensembl transcript including schematic representation, and UCSC links where relevant:
    ENST00000368921(uc001ewq.3)

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    8/19 QIAGEN miScript miRNA Assays for microRNAs that regulate MLLT11 (see all 19):
    hsa-miR-3128 hsa-miR-136 hsa-miR-29c hsa-miR-29a hsa-miR-507 hsa-miR-339-5p hsa-miR-10b* hsa-miR-511
    SwitchGear 3'UTR luciferase reporter plasmidMLLT11 3' UTR sequence
    Inhib. RNA
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    Additional cDNA sequence: 

    AK056089.1 AK057755.1 BC006471.2 BC007079.1 BC008445.1 BC009624.1 BC019253.1 BC021703.1 
    BC022448.1 BC032996.1 BT006799.1 CR456879.1 CR542150.1 U16954.1 

    21 DOTS entries:

    DT.456205  DT.92455561  DT.100816681  DT.100816676  DT.100816688  DT.206970  DT.100816677  DT.100816680 
    DT.121380265  DT.121380314  DT.97786331  DT.100672211  DT.100816679  DT.121380278  DT.91757184  DT.95157303 
    DT.95157310  DT.95157315  DT.95157318  DT.100818449  DT.121380198 

    24/554 AceView cDNA sequences (see all 554):

    BP428957 CB143140 CR604855 CR614314 BX952073 BX446046 BQ640121 Z40244 
    C05168 Z44286 CB126709 BF970015 CR608900 AW592724 BM722060 BQ900990 
    AI554137 BX463420 BQ000958 AL538363 BI549683 T32058 BC019253 BP337006 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    MLLT11 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: CATTCCTACT

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)

    About this image

    MLLT11 expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
    2 LifeMap In Vivo Development Anatomical Compartments/Cells 
    Tissue Anatomical Compartment CellCategory (developmental path)
    EyeRetinaEye
    HeartRight VentricleHeart
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization
    Stem Cell Differentiation: 1 LifeMap Cell 
    NameCategory
    Posterior foregut-like cells (A scalable, suspensi...)

    See MLLT11 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for MLLT11

    SOURCE GeneReport for Unigene cluster: Hs.75823

    UniProtKB/Swiss-Prot: AF1Q_HUMAN, Q13015
    Tissue specificity: Highly expressed in thymus and all leukemic cell lines

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    In Situ
    Assay Products:
     

     
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of chordates.

    Orthologs for MLLT11 gene from 2/8 species (see all 8)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Mllt111 , 5 myeloid/lymphoid or mixed-lineage leukemia (trithorax more1, 5 89.51(n)1
    87.64(a)1
      3 (40.74 cM)5
    567721  NM_019914.41  NP_064298.11 
     952191355 
    zebrafish
    (Danio rerio)
    Actinopterygii mllt116
    myeloid/lymphoid or mixed-lineage leukemia (tritho...
    48(a)
    1 ↔ 1
    19(8068189-8073199)


    ENSEMBL Gene Tree for MLLT11 (if available)
    TreeFam Gene Tree for MLLT11 (if available) 

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
      --

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/191 NCBI SNPs in MLLT11 are shown (see all 191    About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 1 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1485396141,2
    C,--151030173(+) ACAAA-/ACACA 
     CACACAC
    ACACA
    3 -- us2k1 int10--------
    rs710901231,2
    C--151030174(+) ACACA-/CACACAC 3 -- int1 us2k11Minor allele frequency- CA:0.00NA 2
    rs2011633721,2
    --151030221(+) AGGTT-/GTTTTT 3 -- us2k1 int10--------
    rs785802761,2
    F,--151030322(+) TCTTCT/CCACCA 3 -- us2k1 int11Minor allele frequency- C:0.02NA 120
    rs1152096311,2
    F,--151030342(+) AGGAGT/AAACCA 3 -- us2k1 int12Minor allele frequency- A:0.01WA NA 238
    rs1460603511,2
    --151030355(+) AGGAGC/TGGAAG 3 -- us2k1 int10--------
    rs412666161,2
    --151030370(+) AACACA/GCTGTC 3 -- us2k1 int10--------
    rs1493502181,2
    --151030446(+) TGGTGA/GCAGGT 3 -- us2k1 int10--------
    rs741250641,2
    C,--151030488(+) GGAAAC/TCCCCA 3 -- us2k1 int12Minor allele frequency- T:0.15WA 120
    rs1169495711,2
    C,F,--151030508(+) GGCAGG/ACTGTA 3 -- int1 us2k11Minor allele frequency- A:0.03EA 120

    HapMap Linkage Disequilibrium report for MLLT11 (151030234 - 151040973 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
          Database of Genomic Variants (DGV) variations for MLLT11: --

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    MLLT11 for disorders           About GeneDecksing

    OMIM gene information: 604684    OMIM disorders: --

    UniProtKB/Swiss-Prot: AF1Q_HUMAN, Q13015
  • Note=A chromosomal aberration involving MLLT11 is found in acute leukemias. Translocation t(1;11)(q21;q23)
  • with MLL

    8 diseases for MLLT11:    About MalaCards
    leukemia    acute myelomonocytic leukemia    myelomonocytic leukemia    acute myeloid leukemia
    myeloid leukemia    breast cancer    neuronitis    carcinoma

    2 Novoseek disease relationships for MLLT11 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    leukemogenesis 70.3 2 15217837 (1)
    leukemia 32.1 1 15217837 (1)


    Export disorders for MLLT11 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for MLLT11 gene, integrated from 9 sources (see all 20):
    (articles sorted by number of sources associating them with MLLT11)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. A novel gene, AF1q, fused to MLL in t(1;11)(q21;q23), is specifically expressed in leukemic and immature hematopoietic cells. (PubMed id 7833468)1, 2, 3, 9 Tse W.... Cohen A. (1995)
    2. The DNA sequence and biological annotation of human chromosome 1. (PubMed id 16710414)1, 2 Gregory S.G.... Bentley D.R. (2006)
    3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    4. AF1q, a differentially expressed gene during neuronal differentiation, transforms HEK cells into neuron-like cells. (PubMed id 15530661)1, 9 Lin H.J....Ma W. (2004)
    5. Methods for quantification of in vivo changes in prote in ubiquitination following proteasome and deubiquitinase inhibition. (PubMed id 22505724)1 Udeshi N.D....Carr S.A. (2012)
    6. AF1q: a novel mediator of basal and 4-HPR-induced apop tosis in ovarian cancer cells. (PubMed id 22761939)1 Tiberio P....Appierto V. (2012)
    7. Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (2011)
    8. A proteome-wide, quantitative survey of in vivo ubiqui tylation sites reveals widespread regulatory roles. (PubMed id 21890473)1 Wagner S.A....Choudhary C. (2011)
    9. Systematic and quantitative assessment of the ubiquiti n-modified proteome. (PubMed id 21906983)1 Kim W....Gygi S.P. (2011)
    10. AF1q/MLLT11 regulates the emergence of human prothymo cytes through cooperative interaction with the Notch signaling pathway. (PubMed id 21715312)1 Parcelier A....Canque B. (2011)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
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    OMIM
    NCBI Bookshelf
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 10962 HGNC: 16997 AceView: AF1Q Ensembl:ENSG00000213190 euGenes: HUgn10962
    ECgene: MLLT11 H-InvDB: MLLT11

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for MLLT11 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for MLLT11 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for MLLT11 gene:
    Search GeneIP for patents involving MLLT11

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences),
    In Situ Hybridization Assays from
    Advanced Cell Diagnostics
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