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Aliases for MLLT11 Gene

Aliases for MLLT11 Gene

  • Myeloid/Lymphoid Or Mixed-Lineage Leukemia (Trithorax Homolog, Drosophila); Translocated To, 11 2 3
  • AF1Q 3 4 6
  • ALL1 Fused Gene From Chromosome 1q 2 3
  • ALL1-Fused Gene From Chromosome 1q 3
  • Protein AF1q 3

External Ids for MLLT11 Gene

Previous GeneCards Identifiers for MLLT11 Gene

  • GC01P147835
  • GC01P147845
  • GC01P149286
  • GC01P149298
  • GC01P122409

Summaries for MLLT11 Gene

Entrez Gene Summary for MLLT11 Gene

  • The gene variously symbolized ALL1, HRX, or MLL located on 11q23 has been demonstrated to be fused with a number of translocation partners in cases of leukemia. t(1;11)(q21;q23) translocations that fused the MLL gene to a gene on chromosomal band 1q21 in 2 infants with acute myelomonocytic leukemia have been demonstrated. The N-terminal portion of the MLL gene is critical for leukemogenesis in translocations involving band 11q23. This gene encodes 90 amino acids. It was found to be highly expressed in the thymus but not in peripheral lymphoid tissues. In contrast to its restricted distribution in normal hematopoietic tissue, this gene was expressed in all leukemic cell lines tested. [provided by RefSeq, Jul 2008]

GeneCards Summary for MLLT11 Gene

MLLT11 (Myeloid/Lymphoid Or Mixed-Lineage Leukemia (Trithorax Homolog, Drosophila); Translocated To, 11) is a Protein Coding gene. Diseases associated with MLLT11 include acute myelomonocytic leukemia and leukemia.

No data available for UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MLLT11 Gene

Genomics for MLLT11 Gene

Regulatory Elements for MLLT11 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for MLLT11 Gene

151,057,758 bp from pter
151,068,497 bp from pter
10,740 bases
Plus strand

Genomic View for MLLT11 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for MLLT11 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MLLT11 Gene

Proteins for MLLT11 Gene

  • Protein details for MLLT11 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Protein AF1q
    Protein Accession:
    Secondary Accessions:

    Protein attributes for MLLT11 Gene

    90 amino acids
    Molecular mass:
    10061 Da
    Quaternary structure:
    No Data Available

neXtProt entry for MLLT11 Gene

Proteomics data for MLLT11 Gene at MOPED

Post-translational modifications for MLLT11 Gene

  • Ubiquitination at Lys39, Lys47, and Lys59
  • Modification sites at PhosphoSitePlus

Other Protein References for MLLT11 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

No data available for DME Specific Peptides for MLLT11 Gene

Domains for MLLT11 Gene

Protein Domains for MLLT11 Gene


Suggested Antigen Peptide Sequences for MLLT11 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the MLLT11 family.
  • Belongs to the MLLT11 family.
genes like me logo Genes that share domains with MLLT11: view

No data available for Gene Families for MLLT11 Gene

Function for MLLT11 Gene

Gene Ontology (GO) - Molecular Function for MLLT11 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003674 molecular_function ND --
genes like me logo Genes that share ontologies with MLLT11: view

Animal Model Products

miRNA for MLLT11 Gene

miRTarBase miRNAs that target MLLT11

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , Transcription Factor Targets and HOMER Transcription for MLLT11 Gene

Localization for MLLT11 Gene

Subcellular locations from

Jensen Localization Image for MLLT11 Gene COMPARTMENTS Subcellular localization image for MLLT11 gene
Compartment Confidence
extracellular 3
cytosol 1
mitochondrion 1
nucleus 1

Gene Ontology (GO) - Cellular Components for MLLT11 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular IDA 18852119
genes like me logo Genes that share ontologies with MLLT11: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for MLLT11 Gene

Pathways for MLLT11 Gene

SuperPathways for MLLT11 Gene

No Data Available

Interacting Proteins for MLLT11 Gene

STRING Interaction Network Preview (showing 3 interactants - click image to see details)
Selected Interacting proteins: ENSP00000357917 Q13015-AF1Q_HUMAN for MLLT11 Gene via STRING I2D

Gene Ontology (GO) - Biological Process for MLLT11 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0043065 positive regulation of apoptotic process IMP 18852119
GO:0045893 positive regulation of transcription, DNA-templated IDA 18852119
GO:0051901 positive regulation of mitochondrial depolarization IDA 18852119
GO:0090200 positive regulation of release of cytochrome c from mitochondria IDA 18852119
GO:0097191 extrinsic apoptotic signaling pathway IDA 18852119
genes like me logo Genes that share ontologies with MLLT11: view

No data available for Pathways by source for MLLT11 Gene

Transcripts for MLLT11 Gene

mRNA/cDNA for MLLT11 Gene

(1) REFSEQ mRNAs :
(14) Additional mRNA sequences :
(554) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for MLLT11 Gene

Myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 11:
Representative Sequences:

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for MLLT11

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for MLLT11 Gene

No ASD Table

Relevant External Links for MLLT11 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for MLLT11 Gene

mRNA expression in normal human tissues for MLLT11 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues for MLLT11 Gene

This gene is overexpressed in Bone (68.1).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for MLLT11 Gene

SOURCE GeneReport for Unigene cluster for MLLT11 Gene Hs.75823

mRNA Expression by UniProt/SwissProt for MLLT11 Gene

Tissue specificity: Highly expressed in thymus and all leukemic cell lines.
genes like me logo Genes that share expressions with MLLT11: view

Expression partners for MLLT11 Gene

* - Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA differential expression in normal tissues for MLLT11 Gene

Orthologs for MLLT11 Gene

This gene was present in the common ancestor of chordates.

Orthologs for MLLT11 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia MLLT11 35
  • 91.85 (n)
  • 87.78 (a)
MLLT11 36
  • 88 (a)
(Canis familiaris)
Mammalia MLLT11 35
  • 91.85 (n)
  • 88.89 (a)
MLLT11 36
  • 89 (a)
(Mus musculus)
Mammalia Mllt11 35
  • 89.51 (n)
  • 87.64 (a)
Mllt11 16
Mllt11 36
  • 87 (a)
(Pan troglodytes)
Mammalia MLLT11 35
  • 100 (n)
  • 100 (a)
MLLT11 36
  • 100 (a)
(Rattus norvegicus)
Mammalia Mllt11 35
  • 87.64 (n)
  • 84.27 (a)
(Monodelphis domestica)
Mammalia MLLT11 36
  • 74 (a)
(Gallus gallus)
Aves MLLT11 36
  • 55 (a)
(Danio rerio)
Actinopterygii mllt11 36
  • 49 (a)
Species with no ortholog for MLLT11:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for MLLT11 Gene

Gene Tree for MLLT11 (if available)
Gene Tree for MLLT11 (if available)

Paralogs for MLLT11 Gene

(1) SIMAP similar genes for MLLT11 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with MLLT11: view

No data available for Paralogs for MLLT11 Gene

Variants for MLLT11 Gene

Sequence variations from dbSNP and Humsavar for MLLT11 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type MAF
rs15740 -- 151,067,959(+) GCTAC(A/G)AAACA utr-variant-3-prime
rs1524773 -- 151,062,695(-) GCAGG(C/G)CACAT intron-variant
rs1802719 -- 151,067,611(+) TGGTG(C/T)TGATG utr-variant-3-prime
rs2140709 -- 151,064,340(-) AAACC(C/T)AGGTG intron-variant
rs2864883 -- 151,062,915(+) TCTTT(C/G)TGCAC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for MLLT11 Gene

Variant ID Type Subtype PubMed ID
nsv522840 CNV Gain 19592680

Relevant External Links for MLLT11 Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MLLT11 Gene

Disorders for MLLT11 Gene

MalaCards: The human disease database

MalaCards: The human disease database.

Search for MLLT11 Gene in MalaCards »

(2) Diseases for MLLT11 Gene


  • Note=A chromosomal aberration involving MLLT11 is found in acute leukemias. Translocation t(1;11)(q21;q23) with KMT2A/MLL1.

(2) Novoseek inferred disease relationships for MLLT11 Gene

Disease -log(P) Hits PubMed IDs
leukemogenesis 70.3 1
leukemia 32.1 1
genes like me logo Genes that share disorders with MLLT11: view

No data available for OMIM , University of Copenhagen DISEASES , Genatlas and External Links for MLLT11 Gene

Publications for MLLT11 Gene

  1. A novel gene, AF1q, fused to MLL in t(1;11)(q21;q23), is specifically expressed in leukemic and immature hematopoietic cells. (PMID: 7833468) Tse W. … Cohen A. (Blood 1995) 2 3 4 23
  2. AF1q, a differentially expressed gene during neuronal differentiation, transforms HEK cells into neuron-like cells. (PMID: 15530661) Lin H.J. … Ma W. (Brain Res. Mol. Brain Res. 2004) 3 23
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  4. The DNA sequence and biological annotation of human chromosome 1. (PMID: 16710414) Gregory S.G. … Bentley D.R. (Nature 2006) 3 4
  5. Oncogene AF1q enhances doxorubicin-induced apoptosis through BAD-mediated mitochondrial apoptotic pathway. (PMID: 18852119) Co N.N. … Kwok T.T. (Mol. Cancer Ther. 2008) 3

Products for MLLT11 Gene

Sources for MLLT11 Gene

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