Aliases for MLLT11 Gene
- Myeloid/Lymphoid Or Mixed-Lineage Leukemia; Translocated To, 11 2 3
- Myeloid/Lymphoid Or Mixed-Lineage Leukemia (Trithorax Homolog, Drosophila); Translocated To, 11 2 3
- ALL1 Fused Gene From Chromosome 1q 2 3
- AF1Q 3 4
- Myeloid/Lymphoid Or Mixed-Lineage Leukemia Translocated To, 11 5
- ALL1-Fused Gene From Chromosome 1q 3
External Ids for MLLT11 Gene
Previous GeneCards Identifiers for MLLT11 Gene
The gene variously symbolized ALL1, HRX, or MLL located on 11q23 has been demonstrated to be fused with a number of translocation partners in cases of leukemia. t(1;11)(q21;q23) translocations that fused the MLL gene to a gene on chromosomal band 1q21 in 2 infants with acute myelomonocytic leukemia have been demonstrated. The N-terminal portion of the MLL gene is critical for leukemogenesis in translocations involving band 11q23. This gene encodes 90 amino acids. It was found to be highly expressed in the thymus but not in peripheral lymphoid tissues. In contrast to its restricted distribution in normal hematopoietic tissue, this gene was expressed in all leukemic cell lines tested. [provided by RefSeq, Jul 2008]
GeneCards Summary for MLLT11 Gene
MLLT11 (Myeloid/Lymphoid Or Mixed-Lineage Leukemia; Translocated To, 11) is a Protein Coding gene. Diseases associated with MLLT11 include Leukemia, Acute Myelomonocytic, Somatic, Somatic and Myeloid/Lymphoid Or Mixed Lineage Leukemia.
UniProtKB/Swiss-Prot for MLLT11 Gene
Cofactor for the transcription factor TCF7 (PubMed:26079538). Involved in regulation of lymphoid development by driving multipotent hematopoietic progenitor cells towards a T cell fate (PubMed:21715312).