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Aliases for MLLT11 Gene

Aliases for MLLT11 Gene

  • MLLT11, Transcription Factor 7 Cofactor 2 3
  • Myeloid/Lymphoid Or Mixed-Lineage Leukemia (Trithorax Homolog, Drosophila); Translocated To, 11 2 3
  • Myeloid/Lymphoid Or Mixed-Lineage Leukemia; Translocated To, 11 2 3
  • ALL1 Fused Gene From Chromosome 1q 2 3
  • AF1Q 3 4
  • Myeloid/Lymphoid Or Mixed-Lineage Leukemia Translocated To, 11 5
  • Protein AF1q 3

External Ids for MLLT11 Gene

Previous GeneCards Identifiers for MLLT11 Gene

  • GC01P147835
  • GC01P147845
  • GC01P149286
  • GC01P149298
  • GC01P122409

Summaries for MLLT11 Gene

Entrez Gene Summary for MLLT11 Gene

  • The gene variously symbolized ALL1, HRX, or MLL located on 11q23 has been demonstrated to be fused with a number of translocation partners in cases of leukemia. t(1;11)(q21;q23) translocations that fused the MLL gene to a gene on chromosomal band 1q21 in 2 infants with acute myelomonocytic leukemia have been demonstrated. The N-terminal portion of the MLL gene is critical for leukemogenesis in translocations involving band 11q23. This gene encodes 90 amino acids. It was found to be highly expressed in the thymus but not in peripheral lymphoid tissues. In contrast to its restricted distribution in normal hematopoietic tissue, this gene was expressed in all leukemic cell lines tested. [provided by RefSeq, Jul 2008]

GeneCards Summary for MLLT11 Gene

MLLT11 (MLLT11, Transcription Factor 7 Cofactor) is a Protein Coding gene. Diseases associated with MLLT11 include Leukemia, Acute Myelomonocytic, Somatic, Somatic and Myeloid/Lymphoid Or Mixed Lineage Leukemia.

UniProtKB/Swiss-Prot for MLLT11 Gene

  • Cofactor for the transcription factor TCF7 (PubMed:26079538). Involved in regulation of lymphoid development by driving multipotent hematopoietic progenitor cells towards a T cell fate (PubMed:21715312).

No data available for CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MLLT11 Gene

Genomics for MLLT11 Gene

Regulatory Elements for MLLT11 Gene

Enhancers for MLLT11 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH01G151002 1.2 ENCODE dbSUPER 11.2 -55.1 -55064 0.7 ARID4B SIN3A DMAP1 ZNF48 GLIS2 ELK1 SP3 SP5 ZHX2 KAT8 CDC42SE1 CERS2 SEMA6C MLLT11 BNIPL C1orf56 ENSG00000231073 MINDY1 ANXA9
GH01G150602 2.1 FANTOM5 Ensembl ENCODE dbSUPER 4.3 -452.8 -452849 4.1 MLX CREB3L1 DMAP1 YY1 SLC30A9 ZNF143 ZNF263 MEF2D GLIS1 RCOR2 PRPF3 HORMAD1 SETDB1 UBE2D3P3 SF3B4 GOLPH3L MCL1 GABPB2 RPS10P6 CTSS
GH01G151986 2.1 FANTOM5 Ensembl ENCODE dbSUPER 3.8 +936.7 936725 16.2 HDGF FOXA2 PKNOX1 ARNT ARID4B SIN3A YBX1 FEZF1 ZNF2 ZBTB7B THEM4 GABPB2 ENSG00000229021 LYSMD1 VPS72 MRPL9 S100A11 THEM5 S100A10 FLG-AS1
GH01G151054 1.7 Ensembl ENCODE dbSUPER 0.7 +1.2 1246 9.9 CREB3L1 AGO1 YBX1 FEZF1 DMAP1 ZNF143 ZNF263 SP3 TBX21 MEF2D BNIPL GABPB2 PSMD4 ECM1 MLLT11 CDC42SE1
GH01G151047 1.3 ENCODE dbSUPER 0.4 -9.6 -9599 2.1 HDGF MLX AGO1 ARID4B SIN3A DMAP1 ZBTB7B YY1 ZNF121 GLIS2 SEMA6C CTSS C1orf56 MLLT11
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around MLLT11 on UCSC Golden Path with GeneCards custom track

Genomic Location for MLLT11 Gene

Chromosome:
1
Start:
151,057,758 bp from pter
End:
151,068,497 bp from pter
Size:
10,740 bases
Orientation:
Plus strand

Genomic View for MLLT11 Gene

Genes around MLLT11 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MLLT11 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MLLT11 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MLLT11 Gene

Proteins for MLLT11 Gene

  • Protein details for MLLT11 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q13015-AF1Q_HUMAN
    Recommended name:
    Protein AF1q
    Protein Accession:
    Q13015

    Protein attributes for MLLT11 Gene

    Size:
    90 amino acids
    Molecular mass:
    10061 Da
    Quaternary structure:
    • Interacts with HSPA8 and LAMP2 isoform A; the interaction may target MLLT11 for degradation via chaperone-mediated autophagy (PubMed:24880125). Interacts with TCF7 (PubMed:26079538).

neXtProt entry for MLLT11 Gene

Post-translational modifications for MLLT11 Gene

  • Ubiquitinated, leading to degradation.
  • Ubiquitination at Lys39, Lys47, and posLast=5959
  • Modification sites at PhosphoSitePlus

Other Protein References for MLLT11 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for MLLT11 Gene

Domains & Families for MLLT11 Gene

Protein Domains for MLLT11 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for MLLT11 Gene

Graphical View of Domain Structure for InterPro Entry

Q13015

UniProtKB/Swiss-Prot:

AF1Q_HUMAN :
  • Belongs to the MLLT11 family.
Family:
  • Belongs to the MLLT11 family.
genes like me logo Genes that share domains with MLLT11: view

No data available for Gene Families for MLLT11 Gene

Function for MLLT11 Gene

Molecular function for MLLT11 Gene

UniProtKB/Swiss-Prot Function:
Cofactor for the transcription factor TCF7 (PubMed:26079538). Involved in regulation of lymphoid development by driving multipotent hematopoietic progenitor cells towards a T cell fate (PubMed:21715312).

Gene Ontology (GO) - Molecular Function for MLLT11 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003674 molecular_function ND --
genes like me logo Genes that share ontologies with MLLT11: view
genes like me logo Genes that share phenotypes with MLLT11: view

Human Phenotype Ontology for MLLT11 Gene

HPO Id HPO Name Alternative Ids Definition Synonyms

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targets and HOMER Transcription for MLLT11 Gene

Localization for MLLT11 Gene

Subcellular locations from UniProtKB/Swiss-Prot for MLLT11 Gene

Nucleus. Cytoplasm. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Note=Continuous nuclear export is followed by degradation. {ECO:0000269 PubMed:21715312}.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for MLLT11 gene
Compartment Confidence
nucleus 5
cytosol 5
extracellular 3
cytoskeleton 3
mitochondrion 1

Gene Ontology (GO) - Cellular Components for MLLT11 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular IDA 18852119
GO:0005634 nucleus IEA --
GO:0005654 nucleoplasm IDA --
GO:0005737 cytoplasm IEA --
GO:0005815 microtubule organizing center IEA --
genes like me logo Genes that share ontologies with MLLT11: view

Pathways & Interactions for MLLT11 Gene

SuperPathways for MLLT11 Gene

No Data Available

Interacting Proteins for MLLT11 Gene

STRING Interaction Network Preview (showing 1 interactants - click image to see details)
http://version10.5.string-db.org/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000357917%0d%0a9606.ENSP00000220592%0d%0a
Selected Interacting proteins: Q13015-AF1Q_HUMAN ENSP00000357917 for MLLT11 Gene via IID STRING

Gene Ontology (GO) - Biological Process for MLLT11 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0043065 positive regulation of apoptotic process IMP 18852119
GO:0045893 positive regulation of transcription, DNA-templated IDA 18852119
GO:0051901 positive regulation of mitochondrial depolarization IDA 18852119
GO:0090200 positive regulation of release of cytochrome c from mitochondria IDA 18852119
GO:0097190 apoptotic signaling pathway IEA --
genes like me logo Genes that share ontologies with MLLT11: view

No data available for Pathways by source and SIGNOR curated interactions for MLLT11 Gene

Drugs & Compounds for MLLT11 Gene

No Compound Related Data Available

Transcripts for MLLT11 Gene

mRNA/cDNA for MLLT11 Gene

(1) REFSEQ mRNAs :
(14) Additional mRNA sequences :
(554) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for MLLT11 Gene

Myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 11:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for MLLT11 Gene

No ASD Table

Relevant External Links for MLLT11 Gene

GeneLoc Exon Structure for
MLLT11
ECgene alternative splicing isoforms for
MLLT11

Expression for MLLT11 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for MLLT11 Gene

Protein differential expression in normal tissues from HIPED for MLLT11 Gene

This gene is overexpressed in Bone (68.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for MLLT11 Gene



Protein tissue co-expression partners for MLLT11 Gene

NURSA nuclear receptor signaling pathways regulating expression of MLLT11 Gene:

MLLT11

SOURCE GeneReport for Unigene cluster for MLLT11 Gene:

Hs.75823

mRNA Expression by UniProt/SwissProt for MLLT11 Gene:

Q13015-AF1Q_HUMAN
Tissue specificity: Expressed in myoepithelial cells of normal breast tissue (at protein level) (PubMed:26079538). Highly expressed in thymus (PubMed:7833468). Expressed in colon, small intestine, prostate and ovary. Not detected in peripheral blood lymphocytes and spleen (PubMed:7833468).

Evidence on tissue expression from TISSUES for MLLT11 Gene

  • Nervous system(5)
  • Lung(4.4)
  • Bone marrow(4.1)
  • Heart(2)

Phenotype-based relationships between genes and organs from Gene ORGANizer for MLLT11 Gene

Germ Layers:
  • mesoderm
Systems:
  • immune
  • lymphatic
Organs:
General:
  • blood
  • bone marrow
  • white blood cell
genes like me logo Genes that share expression patterns with MLLT11: view

Primer Products

No data available for mRNA differential expression in normal tissues for MLLT11 Gene

Orthologs for MLLT11 Gene

This gene was present in the common ancestor of chordates.

Orthologs for MLLT11 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia MLLT11 34 35
  • 100 (n)
cow
(Bos Taurus)
Mammalia MLLT11 34 35
  • 91.85 (n)
dog
(Canis familiaris)
Mammalia MLLT11 34 35
  • 91.85 (n)
mouse
(Mus musculus)
Mammalia Mllt11 34 16 35
  • 89.51 (n)
rat
(Rattus norvegicus)
Mammalia Mllt11 34
  • 87.64 (n)
oppossum
(Monodelphis domestica)
Mammalia MLLT11 35
  • 74 (a)
OneToOne
chicken
(Gallus gallus)
Aves MLLT11 35
  • 55 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii mllt11 35
  • 49 (a)
OneToOne
Species where no ortholog for MLLT11 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for MLLT11 Gene

ENSEMBL:
Gene Tree for MLLT11 (if available)
TreeFam:
Gene Tree for MLLT11 (if available)

Paralogs for MLLT11 Gene

(1) SIMAP similar genes for MLLT11 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with MLLT11: view

No data available for Paralogs for MLLT11 Gene

Variants for MLLT11 Gene

Sequence variations from dbSNP and Humsavar for MLLT11 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
rs1000561407 -- 151,063,834(+) AGAAA(C/G)TGATA intron-variant
rs1000745137 -- 151,066,553(+) GGAAG(C/G)CCTTG intron-variant
rs1000895962 -- 151,061,342(+) CAAGG(C/T)CCTGT intron-variant, upstream-variant-2KB
rs1001036557 -- 151,063,647(+) GTCTC(C/G)ATCTC intron-variant
rs1001518189 -- 151,059,272(+) TCCTT(C/T)TTTTC intron-variant, upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for MLLT11 Gene

Variant ID Type Subtype PubMed ID
nsv522840 CNV gain 19592680

Variation tolerance for MLLT11 Gene

Residual Variation Intolerance Score: 49.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.12; 2.79% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for MLLT11 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MLLT11

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MLLT11 Gene

Disorders for MLLT11 Gene

MalaCards: The human disease database

(4) MalaCards diseases for MLLT11 Gene - From: OMIM, DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
leukemia, acute myelomonocytic, somatic, somatic
  • leukemia, juvenile myelomonocytic, somatic
myeloid/lymphoid or mixed lineage leukemia
  • mll
leukemia
retinitis pigmentosa 42
  • rp42
- elite association - COSMIC cancer census association via MalaCards

UniProtKB/Swiss-Prot

AF1Q_HUMAN
  • Note=A chromosomal aberration involving MLLT11 is found in acute leukemias. Translocation t(1;11)(q21;q23) with KMT2A/MLL1.

Relevant External Links for MLLT11

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
MLLT11
genes like me logo Genes that share disorders with MLLT11: view

No data available for Genatlas for MLLT11 Gene

Publications for MLLT11 Gene

  1. A novel gene, AF1q, fused to MLL in t(1;11)(q21;q23), is specifically expressed in leukemic and immature hematopoietic cells. (PMID: 7833468) Tse W. … Cohen A. (Blood 1995) 2 3 4 22 64
  2. AF1q is a novel TCF7 co-factor which activates CD44 and promotes breast cancer metastasis. (PMID: 26079538) Park J. … Tse W. (Oncotarget 2015) 3 4 64
  3. Degradation of AF1Q by chaperone-mediated autophagy. (PMID: 24880125) Li P. … Ji C. (Exp. Cell Res. 2014) 3 4 64
  4. AF1q/MLLT11 regulates the emergence of human prothymocytes through cooperative interaction with the Notch signaling pathway. (PMID: 21715312) Parcelier A. … Canque B. (Blood 2011) 3 4 64
  5. The DNA sequence and biological annotation of human chromosome 1. (PMID: 16710414) Gregory S.G. … Bentley D.R. (Nature 2006) 3 4 64

Products for MLLT11 Gene

Sources for MLLT11 Gene

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