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Aliases for MLLT11 Gene

Aliases for MLLT11 Gene

  • Myeloid/Lymphoid Or Mixed-Lineage Leukemia; Translocated To, 11 2 3
  • Myeloid/Lymphoid Or Mixed-Lineage Leukemia (Trithorax Homolog, Drosophila); Translocated To, 11 2 3
  • ALL1 Fused Gene From Chromosome 1q 2 3
  • AF1Q 3 4
  • ALL1-Fused Gene From Chromosome 1q 3

External Ids for MLLT11 Gene

Previous GeneCards Identifiers for MLLT11 Gene

  • GC01P147835
  • GC01P147845
  • GC01P149286
  • GC01P149298
  • GC01P122409

Summaries for MLLT11 Gene

Entrez Gene Summary for MLLT11 Gene

  • The gene variously symbolized ALL1, HRX, or MLL located on 11q23 has been demonstrated to be fused with a number of translocation partners in cases of leukemia. t(1;11)(q21;q23) translocations that fused the MLL gene to a gene on chromosomal band 1q21 in 2 infants with acute myelomonocytic leukemia have been demonstrated. The N-terminal portion of the MLL gene is critical for leukemogenesis in translocations involving band 11q23. This gene encodes 90 amino acids. It was found to be highly expressed in the thymus but not in peripheral lymphoid tissues. In contrast to its restricted distribution in normal hematopoietic tissue, this gene was expressed in all leukemic cell lines tested. [provided by RefSeq, Jul 2008]

GeneCards Summary for MLLT11 Gene

MLLT11 (Myeloid/Lymphoid Or Mixed-Lineage Leukemia; Translocated To, 11) is a Protein Coding gene. Diseases associated with MLLT11 include leukemia, acute myelomonocytic, somatic, somatic and myeloid/lymphoid or mixed lineage leukemia.

No data available for UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MLLT11 Gene

Genomics for MLLT11 Gene

Regulatory Elements for MLLT11 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for MLLT11 Gene

Chromosome:
1
Start:
151,057,758 bp from pter
End:
151,068,497 bp from pter
Size:
10,740 bases
Orientation:
Plus strand

Genomic View for MLLT11 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
GeneLoc Logo Gene Density

RefSeq DNA sequence for MLLT11 Gene

Proteins for MLLT11 Gene

  • Protein details for MLLT11 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q13015-AF1Q_HUMAN
    Recommended name:
    Protein AF1q
    Protein Accession:
    Q13015

    Protein attributes for MLLT11 Gene

    Size:
    90 amino acids
    Molecular mass:
    10061 Da
    Quaternary structure:
    No Data Available

neXtProt entry for MLLT11 Gene

Proteomics data for MLLT11 Gene at MOPED

Post-translational modifications for MLLT11 Gene

  • Ubiquitination at Lys 39, Lys 47, and Lys 59
  • Modification sites at PhosphoSitePlus

Other Protein References for MLLT11 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

No data available for DME Specific Peptides for MLLT11 Gene

Domains & Families for MLLT11 Gene

Protein Domains for MLLT11 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for MLLT11 Gene

Graphical View of Domain Structure for InterPro Entry

Q13015

UniProtKB/Swiss-Prot:

AF1Q_HUMAN :
  • Belongs to the MLLT11 family.
Family:
  • Belongs to the MLLT11 family.
genes like me logo Genes that share domains with MLLT11: view

No data available for Gene Families for MLLT11 Gene

Function for MLLT11 Gene

Gene Ontology (GO) - Molecular Function for MLLT11 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003674 molecular_function ND --
genes like me logo Genes that share ontologies with MLLT11: view

Phenotypes for MLLT11 Gene

genes like me logo Genes that share phenotypes with MLLT11: view

Animal Model Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targets and HOMER Transcription for MLLT11 Gene

Localization for MLLT11 Gene

Gene Ontology (GO) - Cellular Components for MLLT11 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular IDA 18852119
GO:0005737 cytoplasm IEA --
genes like me logo Genes that share ontologies with MLLT11: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Subcellular locations from COMPARTMENTS for MLLT11 Gene

Pathways & Interactions for MLLT11 Gene

SuperPathways for MLLT11 Gene

No Data Available

Interacting Proteins for MLLT11 Gene

STRING Interaction Network Preview (showing 3 interactants - click image to see details)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000357917%0d%0a9606.ENSP00000344818%0d%0a9606.ENSP00000220592%0d%0a9606.ENSP00000378324%0d%0a
Selected Interacting proteins: Q13015-AF1Q_HUMAN ENSP00000357917 for MLLT11 Gene via I2D STRING

Gene Ontology (GO) - Biological Process for MLLT11 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0043065 positive regulation of apoptotic process IMP 18852119
GO:0045893 positive regulation of transcription, DNA-templated IDA 18852119
GO:0051901 positive regulation of mitochondrial depolarization IDA 18852119
GO:0090200 positive regulation of release of cytochrome c from mitochondria IDA 18852119
GO:0097191 extrinsic apoptotic signaling pathway IDA 18852119
genes like me logo Genes that share ontologies with MLLT11: view

No data available for Pathways by source and SIGNOR curated interactions for MLLT11 Gene

Drugs & Compounds for MLLT11 Gene

No Compound Related Data Available

Transcripts for MLLT11 Gene

mRNA/cDNA for MLLT11 Gene

(1) REFSEQ mRNAs :
(14) Additional mRNA sequences :
(554) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for MLLT11 Gene

Myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 11:
Representative Sequences:

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for MLLT11

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for MLLT11 Gene

No ASD Table

Relevant External Links for MLLT11 Gene

GeneLoc Exon Structure for
MLLT11
ECgene alternative splicing isoforms for
MLLT11

Expression for MLLT11 Gene

mRNA expression in normal human tissues for MLLT11 Gene

Protein differential expression in normal tissues from HIPED for MLLT11 Gene

This gene is overexpressed in Bone (68.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for MLLT11 Gene



SOURCE GeneReport for Unigene cluster for MLLT11 Gene Hs.75823

mRNA Expression by UniProt/SwissProt for MLLT11 Gene

Q13015-AF1Q_HUMAN
Tissue specificity: Highly expressed in thymus and all leukemic cell lines.
genes like me logo Genes that share expression patterns with MLLT11: view

Protein tissue co-expression partners for MLLT11 Gene

Primer Products

In Situ Assay Products

No data available for mRNA differential expression in normal tissues for MLLT11 Gene

Orthologs for MLLT11 Gene

This gene was present in the common ancestor of chordates.

Orthologs for MLLT11 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia MLLT11 35
  • 91.85 (n)
  • 87.78 (a)
MLLT11 36
  • 88 (a)
OneToOne
dog
(Canis familiaris)
Mammalia MLLT11 35
  • 91.85 (n)
  • 88.89 (a)
MLLT11 36
  • 89 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Mllt11 35
  • 89.51 (n)
  • 87.64 (a)
Mllt11 16
Mllt11 36
  • 87 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia MLLT11 35
  • 100 (n)
  • 100 (a)
MLLT11 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Mllt11 35
  • 87.64 (n)
  • 84.27 (a)
oppossum
(Monodelphis domestica)
Mammalia MLLT11 36
  • 74 (a)
OneToOne
chicken
(Gallus gallus)
Aves MLLT11 36
  • 55 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii mllt11 36
  • 49 (a)
OneToOne
Species with no ortholog for MLLT11:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for MLLT11 Gene

ENSEMBL:
Gene Tree for MLLT11 (if available)
TreeFam:
Gene Tree for MLLT11 (if available)

Paralogs for MLLT11 Gene

(1) SIMAP similar genes for MLLT11 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with MLLT11: view

No data available for Paralogs for MLLT11 Gene

Variants for MLLT11 Gene

Sequence variations from dbSNP and Humsavar for MLLT11 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type MAF
rs15740 -- 151,067,959(+) GCTAC(A/G)AAACA utr-variant-3-prime
rs1524773 -- 151,062,695(-) GCAGG(C/G)CACAT intron-variant
rs1802719 -- 151,067,611(+) TGGTG(C/T)TGATG utr-variant-3-prime
rs2140709 -- 151,064,340(-) AAACC(C/T)AGGTG intron-variant
rs2864883 -- 151,062,915(+) TCTTT(C/G)TGCAC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for MLLT11 Gene

Variant ID Type Subtype PubMed ID
nsv522840 CNV Gain 19592680

Variation tolerance for MLLT11 Gene

Residual Variation Intolerance Score: 49.21% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.12; 2.79% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for MLLT11 Gene

HapMap Linkage Disequilibrium report
MLLT11

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MLLT11 Gene

Disorders for MLLT11 Gene

MalaCards: The human disease database

(3) MalaCards diseases for MLLT11 Gene - From: OMIM, DISEASES, and GeneCards

Disorder Aliases PubMed IDs
leukemia, acute myelomonocytic, somatic, somatic
  • leukemia, juvenile myelomonocytic, somatic
myeloid/lymphoid or mixed lineage leukemia
  • mll
leukemia, acute myeloid
  • leukemia, acute myeloid, somatic
- elite association

UniProtKB/Swiss-Prot

AF1Q_HUMAN
  • Note=A chromosomal aberration involving MLLT11 is found in acute leukemias. Translocation t(1;11)(q21;q23) with KMT2A/MLL1.

Relevant External Links for MLLT11

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
MLLT11
genes like me logo Genes that share disorders with MLLT11: view

No data available for Genatlas for MLLT11 Gene

Publications for MLLT11 Gene

  1. A novel gene, AF1q, fused to MLL in t(1;11)(q21;q23), is specifically expressed in leukemic and immature hematopoietic cells. (PMID: 7833468) Tse W. … Cohen A. (Blood 1995) 2 23 67
  2. Gene expression profile analysis of an isogenic tumour metastasis model reveals a functional role for oncogene AF1Q in breast cancer metastasis. (PMID: 16979889) Li D.Q. … Shao Z.M. (Eur. J. Cancer 2006) 23 67
  3. Elevated expression of the AF1q gene, an MLL fusion partner, is an independent adverse prognostic factor in pediatric acute myeloid leukemia. (PMID: 15217837) Tse W. … Radich J.P. (Blood 2004) 23 67
  4. AF1q, a differentially expressed gene during neuronal differentiation, transforms HEK cells into neuron-like cells. (PMID: 15530661) Lin H.J. … Ma W. (Brain Res. Mol. Brain Res. 2004) 23 67
  5. Degradation of AF1Q by chaperone-mediated autophagy. (PMID: 24880125) Li P. … Ji C. (Exp. Cell Res. 2014) 67

Products for MLLT11 Gene

Sources for MLLT11 Gene

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