Free for academic non-profit institutions. Other users need a Commercial license

Aliases for MLLT10 Gene

Aliases for MLLT10 Gene

  • Myeloid/Lymphoid Or Mixed-Lineage Leukemia; Translocated To, 10 2 3
  • Myeloid/Lymphoid Or Mixed-Lineage Leukemia (Trithorax Homolog, Drosophila); Translocated To, 10 2 3
  • ALL1-Fused Gene From Chromosome 10 Protein 3 4
  • AF10 3 4
  • Myeloid/Lymphoid Or Mixed-Lineage Leukemia (Trithorax (Drosophila) Homolog); Translocated To, 10 2
  • Myeloid/Lymphoid Or Mixed-Lineage Leukemia Translocated To, 10 5
  • Type III AF10 Protein 3
  • Type IV AF10 Protein 3
  • Type I AF10 Protein 3

External Ids for MLLT10 Gene

Previous GeneCards Identifiers for MLLT10 Gene

  • GC10P021558
  • GC10P021973
  • GC10P021827
  • GC10P021863
  • GC10P021469
  • GC10P021825

Summaries for MLLT10 Gene

Entrez Gene Summary for MLLT10 Gene

  • This gene encodes a transcription factor and has been identified as a partner gene involved in several chromosomal rearrangements resulting in various leukemias. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2010]

GeneCards Summary for MLLT10 Gene

MLLT10 (Myeloid/Lymphoid Or Mixed-Lineage Leukemia; Translocated To, 10) is a Protein Coding gene. Diseases associated with MLLT10 include leukemia, acute myeloid and precursor t-cell acute lymphoblastic leukemia. GO annotations related to this gene include transcription factor activity, sequence-specific DNA binding. An important paralog of this gene is BRPF1.

UniProtKB/Swiss-Prot for MLLT10 Gene

  • Probably involved in transcriptional regulation. In vitro or as fusion protein with KMT2A/MLL1 has transactivation activity. Binds to cruciform DNA.

Gene Wiki entry for MLLT10 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MLLT10 Gene

Genomics for MLLT10 Gene

Regulatory Elements for MLLT10 Gene

Genomic Location for MLLT10 Gene

Chromosome:
10
Start:
21,524,675 bp from pter
End:
21,743,633 bp from pter
Size:
218,959 bases
Orientation:
Plus strand

Genomic View for MLLT10 Gene

Genes around MLLT10 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MLLT10 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MLLT10 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MLLT10 Gene

Proteins for MLLT10 Gene

  • Protein details for MLLT10 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P55197-AF10_HUMAN
    Recommended name:
    Protein AF-10
    Protein Accession:
    P55197
    Secondary Accessions:
    • B1ANA8
    • Q5JT37
    • Q5VX90
    • Q66K63

    Protein attributes for MLLT10 Gene

    Size:
    1068 amino acids
    Molecular mass:
    113320 Da
    Quaternary structure:
    • Self-associates. Interacts with FSTL3 isoform 2; the interaction enhances MLLT10 in vitro transcriptional activity and self-association. Interacts with YEATS4. Interacts with SS18. Interacts with DOT1L; this interaction also occurs with the KMT2A/MLL1 fusion protein.
    SequenceCaution:
    • Sequence=BC129946; Type=Frameshift; Positions=235; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for MLLT10 Gene

    Alternative splice isoforms for MLLT10 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for MLLT10 Gene

Proteomics data for MLLT10 Gene at MOPED

Post-translational modifications for MLLT10 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Antibody Products

No data available for DME Specific Peptides for MLLT10 Gene

Domains & Families for MLLT10 Gene

Gene Families for MLLT10 Gene

Graphical View of Domain Structure for InterPro Entry

P55197

UniProtKB/Swiss-Prot:

AF10_HUMAN :
  • Contains 2 PHD-type zinc fingers.
Similarity:
  • Contains 2 PHD-type zinc fingers.
genes like me logo Genes that share domains with MLLT10: view

Function for MLLT10 Gene

Molecular function for MLLT10 Gene

UniProtKB/Swiss-Prot Function:
Probably involved in transcriptional regulation. In vitro or as fusion protein with KMT2A/MLL1 has transactivation activity. Binds to cruciform DNA.

Gene Ontology (GO) - Molecular Function for MLLT10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003700 transcription factor activity, sequence-specific DNA binding NAS 7888665
GO:0005515 protein binding IEA,IPI 17868029
genes like me logo Genes that share ontologies with MLLT10: view

Phenotypes for MLLT10 Gene

genes like me logo Genes that share phenotypes with MLLT10: view

Human Phenotype Ontology for MLLT10 Gene

HPO Id HPO Name Alternative Ids Definition Synonyms

Animal Model Products

  • Taconic Biosciences Mouse Models for MLLT10

CRISPR Products

miRNA for MLLT10 Gene

miRTarBase miRNAs that target MLLT10

Inhibitory RNA Products

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targets and HOMER Transcription for MLLT10 Gene

Localization for MLLT10 Gene

Subcellular locations from UniProtKB/Swiss-Prot for MLLT10 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for MLLT10 Gene COMPARTMENTS Subcellular localization image for MLLT10 gene
Compartment Confidence
nucleus 5
cytosol 3

Gene Ontology (GO) - Cellular Components for MLLT10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IDA --
genes like me logo Genes that share ontologies with MLLT10: view

Pathways & Interactions for MLLT10 Gene

SuperPathways for MLLT10 Gene

No Data Available

Gene Ontology (GO) - Biological Process for MLLT10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0045944 positive regulation of transcription from RNA polymerase II promoter IDA 17868029
genes like me logo Genes that share ontologies with MLLT10: view

No data available for Pathways by source and SIGNOR curated interactions for MLLT10 Gene

Drugs & Compounds for MLLT10 Gene

(2) Drugs for MLLT10 Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials

(1) Additional Compounds for MLLT10 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with MLLT10: view

Transcripts for MLLT10 Gene

Unigene Clusters for MLLT10 Gene

Myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 10:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for MLLT10 Gene

No ASD Table

Relevant External Links for MLLT10 Gene

GeneLoc Exon Structure for
MLLT10
ECgene alternative splicing isoforms for
MLLT10

Expression for MLLT10 Gene

mRNA expression in normal human tissues for MLLT10 Gene

Protein differential expression in normal tissues from HIPED for MLLT10 Gene

This gene is overexpressed in Testis (64.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for MLLT10 Gene



SOURCE GeneReport for Unigene cluster for MLLT10 Gene Hs.30385

mRNA Expression by UniProt/SwissProt for MLLT10 Gene

P55197-AF10_HUMAN
Tissue specificity: Expressed abundantly in testis.
genes like me logo Genes that share expression patterns with MLLT10: view

Protein tissue co-expression partners for MLLT10 Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA differential expression in normal tissues for MLLT10 Gene

Orthologs for MLLT10 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for MLLT10 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia LOC519864 35
  • 93.46 (n)
  • 95.47 (a)
MLLT10 36
  • 76 (a)
OneToOne
dog
(Canis familiaris)
Mammalia MLLT10 35
  • 94.16 (n)
  • 95.99 (a)
MLLT10 36
  • 95 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Mllt10 35
  • 90.45 (n)
  • 93.33 (a)
Mllt10 16
Mllt10 36
  • 93 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia MLLT10 35
  • 96.94 (n)
  • 96.25 (a)
MLLT10 36
  • 94 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Mllt10 35
  • 86.78 (n)
  • 91.78 (a)
oppossum
(Monodelphis domestica)
Mammalia MLLT10 36
  • 90 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia MLLT10 36
  • 83 (a)
OneToOne
chicken
(Gallus gallus)
Aves MLLT10 35
  • 84.89 (n)
  • 87.32 (a)
MLLT10 36
  • 86 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia MLLT10 36
  • 77 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia mllt10 35
  • 73.16 (n)
  • 72.53 (a)
Str.16297 35
zebrafish
(Danio rerio)
Actinopterygii mllt10 35
  • 59.77 (n)
  • 57.85 (a)
mllt10 36
  • 50 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea zfp-1 37
  • 59 (a)
zfp-1 36
  • 30 (a)
OneToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes NTO1 36
  • 15 (a)
OneToMany
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.1015 35
sea squirt
(Ciona savignyi)
Ascidiacea CSA.8085 36
  • 32 (a)
OneToMany
Species with no ortholog for MLLT10:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for MLLT10 Gene

ENSEMBL:
Gene Tree for MLLT10 (if available)
TreeFam:
Gene Tree for MLLT10 (if available)

Paralogs for MLLT10 Gene

Paralogs for MLLT10 Gene

(7) SIMAP similar genes for MLLT10 Gene using alignment to 5 proteins:

Pseudogenes.org Pseudogenes for MLLT10 Gene

genes like me logo Genes that share paralogs with MLLT10: view

Variants for MLLT10 Gene

Sequence variations from dbSNP and Humsavar for MLLT10 Gene

SNP ID Clin Chr 10 pos Sequence Context AA Info Type
rs1943 -- 21,696,941(-) CTAAC(A/G)GAAAG intron-variant
rs1261777 -- 21,695,289(-) GGCTG(A/G)GTGCA intron-variant
rs1270799 -- 21,618,494(+) agcga(G/T)actct intron-variant
rs1243179 -- 21,623,650(+) AGTCA(A/G)AATCA intron-variant, upstream-variant-2KB
rs1243180 -- 21,626,690(+) TCTTC(A/T)GTGGC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for MLLT10 Gene

Variant ID Type Subtype PubMed ID
dgv133n67 CNV Gain 20364138
dgv134n67 CNV Gain 20364138
nsv825289 CNV Loss 20364138
dgv135n67 CNV Gain 20364138
dgv622n71 CNV Loss 21882294
dgv623n71 CNV Loss 21882294
esv22595 CNV Gain 19812545
nsv894947 CNV Loss 21882294
esv2609802 CNV Deletion 19546169

Variation tolerance for MLLT10 Gene

Residual Variation Intolerance Score: 4.83% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.03; 37.32% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for MLLT10 Gene

HapMap Linkage Disequilibrium report
MLLT10
Human Gene Mutation Database (HGMD)
MLLT10

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MLLT10 Gene

Disorders for MLLT10 Gene

MalaCards: The human disease database

(8) MalaCards diseases for MLLT10 Gene - From: OMIM, Orphanet, DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
leukemia, acute myeloid
  • leukemia, acute myeloid, somatic
precursor t-cell acute lymphoblastic leukemia
  • precursor t-cell acute lymphoblastic leukemia/lymphoma
acute monocytic leukemia
  • acute monoblastic leukemia and acute monocytic leukemia
myeloid/lymphoid or mixed lineage leukemia
  • mll
acute biphenotypic leukemia
- elite association - COSMIC cancer census association via MalaCards

UniProtKB/Swiss-Prot

AF10_HUMAN
  • Note=A chromosomal aberration involving MLLT10 is associated with acute leukemias. Translocation t(10;11)(p12;q23) with KMT2A/MLL1. The result is a rogue activator protein.
  • Note=A chromosomal aberration involving MLLT10 is associated with diffuse histiocytic lymphomas. Translocation t(10;11)(p13;q14) with PICALM.

Relevant External Links for MLLT10

Genetic Association Database (GAD)
MLLT10
Human Genome Epidemiology (HuGE) Navigator
MLLT10
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
MLLT10
genes like me logo Genes that share disorders with MLLT10: view

No data available for Genatlas for MLLT10 Gene

Publications for MLLT10 Gene

  1. A novel class of zinc finger/leucine zipper genes identified from the molecular cloning of the t(10;11) translocation in acute leukemia. (PMID: 7888665) Chaplin T. … Young B.D. (Blood 1995) 2 3 4 67
  2. AF10-dependent transcription is enhanced by its interaction with FLRG. (PMID: 17868029) Forissier S. … Rimokh R. (Biol. Cell 2007) 3 23
  3. hDOT1L links histone methylation to leukemogenesis. (PMID: 15851025) Okada Y. … Zhang Y. (Cell 2005) 3 23
  4. The leucine zipper motif of the Drosophila AF10 homologue can inhibit PRE-mediated repression: implications for leukemogenic activity of human MLL-AF10 fusions. (PMID: 12482966) Perrin L. … Dura J.M. (Mol. Cell. Biol. 2003) 3 23
  5. The MLL fusion partner AF10 binds GAS41, a protein that interacts with the human SWI/SNF complex. (PMID: 11756182) Debernardi S. … Young B.D. (Blood 2002) 3 23

Products for MLLT10 Gene

Sources for MLLT10 Gene

Back to Top

Content