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MLLT10 Gene

protein-coding   GIFtS: 56
GCID: GC10P021825

Myeloid/Lymphoid Or Mixed-Lineage Leukemia (Trithorax Homolog,...

(Previous names: myeloid/lymphoid or mixed-lineage leukemia (trithorax (Drosophila)...)
  See MLLT10-related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Myeloid/Lymphoid Or Mixed-Lineage Leukemia (Trithorax Homolog,
Drosophila); Translocated To, 101 2
     Protein AF-102
AF102 3 5     Type I AF10 Protein2
ALL1-Fused Gene From Chromosome 10 Protein2 3     Type III AF10 Protein2
Myeloid/Lymphoid Or Mixed-Lineage Leukemia (Trithorax (Drosophila)
Homolog); Translocated To, 101
     Type IV AF10 Protein2

External Ids:    HGNC: 160631   Entrez Gene: 80282   Ensembl: ENSG000000784037   OMIM: 6024095   UniProtKB: P551973   

Export aliases for MLLT10 gene to outside databases

Previous GC identifers: GC10P021558 GC10P021973 GC10P021827 GC10P021863 GC10P021469


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for MLLT10 Gene:
This gene encodes a transcription factor and has been identified as a partner gene involved in several chromosomal
rearrangements resulting in various leukemias. Multiple transcript variants encoding different isoforms have been
found for this gene. (provided by RefSeq, Sep 2010)

GeneCards Summary for MLLT10 Gene:
MLLT10 (myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 10) is a protein-coding gene. Diseases associated with MLLT10 include verrucous papilloma, and acute biphenotypic leukemia. GO annotations related to this gene include sequence-specific DNA binding transcription factor activity. An important paralog of this gene is JADE2.

UniProtKB/Swiss-Prot: AF10_HUMAN, P55197
Function: Probably involved in transcriptional regulation. In vitro or as fusion protein with KMT2A/MLL1 has
transactivation activity. Binds to cruciform DNA

Gene Wiki entry for MLLT10 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000010.10  NT_008705.17  NC_018921.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the MLLT10 gene promoter:
         POU3F1   HFH-1   Ik-3   Arnt   c-Ets-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidMLLT10 promoter sequence
   Search Chromatin IP Primers for MLLT10

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat MLLT10


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 10p12   Ensembl cytogenetic band:  10p12.31   HGNC cytogenetic band: 10p12

MLLT10 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
MLLT10 gene location

GeneLoc information about chromosome 10         GeneLoc Exon Structure

GeneLoc location for GC10P021825:  view genomic region     (about GC identifiers)

Start:
21,823,094 bp from pter      End:
22,032,559 bp from pter
Size:
209,466 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: AF10_HUMAN, P55197 (See protein sequence)
Recommended Name: Protein AF-10  
Size: 1068 amino acids; 113320 Da
Subunit: Self-associates. Interacts with FSTL3 isoform 2; the interaction enhances MLLT10 in vitro transcriptional
activity and self-association. Interacts with YEATS4. Interacts with SS18. Interacts with DOT1L; this interaction
also occurs with the KMT2A/MLL1 fusion protein
Sequence caution: Sequence=BC129946; Type=Frameshift; Positions=235;
Secondary accessions: B1ANA8 Q5JT37 Q5VX90 Q66K63
Alternative splicing: 4 isoforms:  P55197-4   P55197-1   P55197-2   P55197-3   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for MLLT10: NX_P55197

Explore proteomics data for MLLT10 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See MLLT10 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (5 alternative transcripts): 
    NP_001182555.1  NP_001182556.1  NP_001182557.1  NP_001182559.1  NP_004632.1  

    ENSEMBL proteins: 
     ENSP00000366304   ENSP00000366272   ENSP00000307411   ENSP00000366295   ENSP00000397800  
     ENSP00000408281   ENSP00000399883   ENSP00000401406   ENSP00000366258  

    MLLT10 Human Recombinant Protein Products:

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    antibodies-online proteins for MLLT10 (2 products) 

     
    antibodies-online peptides for MLLT10

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    PHF: Zinc fingers, PHD-type

    5 InterPro protein domains:
     IPR001965 Znf_PHD
     IPR013083 Znf_RING/FYVE/PHD
     IPR019786 Zinc_finger_PHD-type_CS
     IPR011011 Znf_FYVE_PHD
     IPR019787 Znf_PHD-finger

    Graphical View of Domain Structure for InterPro Entry P55197

    ProtoNet protein and cluster: P55197

    1 Blocks protein domain: IPB001965 Zn-finger-like

    UniProtKB/Swiss-Prot: AF10_HUMAN, P55197
    Similarity: Contains 2 PHD-type zinc fingers


    Find genes that share domains with MLLT10           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: AF10_HUMAN, P55197
    Function: Probably involved in transcriptional regulation. In vitro or as fusion protein with KMT2A/MLL1 has
    transactivation activity. Binds to cruciform DNA

         Gene Ontology (GO): 4 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003677DNA binding IEA--
    GO:0003700sequence-specific DNA binding transcription factor activity NAS7888665
    GO:0005515protein binding IPI17868029
    GO:0008270zinc ion binding IEA--
         
    Find genes that share ontologies with MLLT10           About GenesLikeMe


    Phenotypes:
         1 GenomeRNAi human phenotype for MLLT10:
     Increased gamma-H2AX phosphory 

    Animal Models:
       genOway: Develop your customized and physiologically relevant rodent model for MLLT10

    miRNA
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    miRTarBase miRNAs that target MLLT10:
    hsa-mir-132-3p (MIRT021746)

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    Selected qRT-PCR Assays for microRNAs that regulate MLLT10 (see all 49):
    hsa-miR-300 hsa-let-7d hsa-miR-128 hsa-miR-139-5p hsa-let-7a-2* hsa-miR-301a hsa-miR-10b* hsa-miR-374c
    SwitchGear 3'UTR luciferase reporter plasmidMLLT10 3' UTR sequence
    Inhib. RNA
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    AF10_HUMAN, P55197: Nucleus
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus5
    cytosol3

    Gene Ontology (GO): 3 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA--
    GO:0005730NOT nucleolus IDA--
    GO:0005737cytoplasm IDA--

    Find genes that share ontologies with MLLT10           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for MLLT10
    Interactions:

        GeneGlobe Interaction Network for MLLT10

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for MLLT10 (P551973 ENSP000003662724) via UniProtKB, MINT, STRING, and/or I2D (see all 31)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    RGPD5Q996663, ENSP000000169464I2D: score=1 STRING: ENSP00000016946
    DOT1LQ8TEK33, ENSP000003816574I2D: score=2 STRING: ENSP00000381657
    NDEL1Q9GZM83, ENSP000003339824I2D: score=2 STRING: ENSP00000333982
    SS18Q155323, ENSP000002691384I2D: score=2 STRING: ENSP00000269138
    MLLT3P425683, ENSP000003696954I2D: score=1 STRING: ENSP00000369695
    About this table

    Gene Ontology (GO): 2 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006351transcription, DNA-templated IEA--
    GO:0045944positive regulation of transcription from RNA polymerase II promoter IDA17868029

    Find genes that share ontologies with MLLT10           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for MLLT10 (AF10)

    3 Novoseek inferred chemical compound relationships for MLLT10 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    af 10 99.3 144 9737689 (7), 11756182 (5), 10221337 (5), 17868029 (5) (see all 40)
    leucine 56.1 10 7662954 (3), 11756182 (2), 12482966 (2), 10602503 (1) (see all 6)
    zinc 12 3 11756182 (1), 7568208 (1), 7662954 (1)



    Find genes that share compounds with MLLT10           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for MLLT10 gene (6 alternative transcripts): 
    NM_001195626.1  NM_001195627.1  NM_001195628.1  NM_001195630.1  NM_004641.3  NM_001009569.1  

    Unigene Cluster for MLLT10:

    Myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 10
    Hs.30385  [show with all ESTs]
    Unigene Representative Sequence: AB209755
    16 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000377100(uc001iqr.2 uc001iqu.2 uc001iqq.2) ENST00000377072(uc001iqs.3 uc001iqv.3 uc001iqt.3)
    ENST00000307729(uc021pny.1 uc001ira.3 uc001irb.3) ENST00000377091
    ENST00000471315 ENST00000495130(uc001iqx.1 uc009xkf.1 uc009xke.1 uc001iqw.1)
    ENST00000476557 ENST00000430455 ENST00000462999 ENST00000480415 ENST00000479634
    ENST00000438473 ENST00000468309 ENST00000420525 ENST00000446906 ENST00000377059

    miRNA
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    Selected qRT-PCR Assays for microRNAs that regulate MLLT10 (see all 49):
    hsa-miR-300 hsa-let-7d hsa-miR-128 hsa-miR-139-5p hsa-let-7a-2* hsa-miR-301a hsa-miR-10b* hsa-miR-374c
    SwitchGear 3'UTR luciferase reporter plasmidMLLT10 3' UTR sequence
    Inhib. RNA
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      QuantiTect SYBR Green Assays in human, mouse, rat MLLT10
      QuantiFast Probe-based Assays in human, mouse, rat MLLT10

    Additional mRNA sequence: 

    AB209755.1 AF060927.1 AF060929.1 AF060932.1 AF060934.1 AF060935.1 AF060936.1 AF060937.1 
    AF060938.1 AF272385.1 AK126642.1 AK301213.1 AK310803.1 AL137295.1 AY598745.1 BC032532.1 
    BC052798.1 BC065376.1 BC080577.1 BC094844.1 BC129946.1 BX640774.1 BX648210.1 U13948.1 

    19 DOTS entries:

    DT.416343  DT.101980714  DT.95172977  DT.95172979  DT.101977940  DT.91741124  DT.121300683  DT.92471719 
    DT.40118519  DT.100764476  DT.107987  DT.121300612  DT.121300661  DT.75135685  DT.101968555  DT.121300666 
    DT.100823172  DT.309851  DT.87017228 

    Selected AceView cDNA sequences (see all 220):

    AI147420 BQ012364 BX385970 NM_004641 BE221740 BX501144 BC052798 AI537971 
    BQ221122 BQ012851 BU931245 AL046668 AA514543 AW129353 BE466876 BU634529 
    AI362588 AI288016 F06859 BM711458 AI630181 AF060938 AW294777 AL704352 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    MLLT10 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TATTAAAATG
    MLLT10 Expression
    About this image

    MLLT10 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    MLLT10 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.30385

    UniProtKB/Swiss-Prot: AF10_HUMAN, P55197
    Tissue specificity: Expressed abundantly in testis

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    In Situ
    Assay Products:
     

     
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals and fungi.

    Orthologs for MLLT10 gene from Selected species (see all 15)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Mllt101 , 5 myeloid/lymphoid or mixed-lineage leukemia (trithorax more1, 5 90.45(n)1
    93.33(a)1
      2 (12.84 cM)5
    173541  NM_001252560.11  NP_001239489.11 
     180643945 
    chicken
    (Gallus gallus)
    Aves MLLT101 myeloid/lymphoid or mixed-lineage leukemia (trithorax more 84.89(n)
    87.32(a)
      420509  XM_004939243.1  XP_004939300.1 
    lizard
    (Anolis carolinensis)
    Reptilia MLLT106
    myeloid/lymphoid or mixed-lineage leukemia (tritho...
    77(a)
    1 ↔ 1
    6(16561580-16710014)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia Str.162972 Transcribed sequence with moderate similarity to protein more 79.48(n)    BX701108.1 
    zebrafish
    (Danio rerio)
    Actinopterygii mllt101 myeloid/lymphoid or mixed-lineage leukemia (trithorax more 59.77(n)
    57.85(a)
      492342  XM_005162622.1  XP_005162679.1 
    worm
    (Caenorhabditis elegans)
    Secernentea zfp-13 Expression: intestine, pharynx, phasmid
    sensilla, more
    59(a)   III(8864569-8866029)   --
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes NTO16
    Subunit of the NuA3 histone acetyltransferase comp...
    15(a)
    1 → many
    XVI(631515-633761) YPR031W


    ENSEMBL Gene Tree for MLLT10 (if available)
    TreeFam Gene Tree for MLLT10 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for MLLT10 gene
    JADE22  BRD12  BRPF12  PHF142  JADE32  JADE12  MLLT62  BRPF32  
    7 SIMAP similar genes for MLLT10 using alignment to 5 protein entries:     AF10_HUMAN (see all proteins):
    MLL/AF10 fusion    AF10    DKFZp686E10210    DKFZp779J0967    JADE2    MLLT6
    BRPF3

    Find genes that share paralogs with MLLT10           About GenesLikeMe


    4 Pseudogenes.org Pseudogenes for MLLT10
    PGOHUM00000259181 PGOHUM00000262355 PGOHUM00000247503 PGOHUM00000245795


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for MLLT10 (see all 3829)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 10 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1436568001,2
    C--21821147(+) AGGAAA/GTAGCA 4 -- us2k10--------
    rs1862903191,2
    --21821154(+) AGCAAA/GTGTTT 4 -- us2k10--------
    rs1910725281,2
    --21821220(+) ATACAA/GATTAA 4 -- us2k10--------
    rs70844541,2
    C,F,A,H--21821274(+) AATGTG/ATTTTT 4 -- us2k112Minor allele frequency- A:0.28NS EA NA WA CSA 668
    rs1480790731,2
    --21821322(+) GGGAGG/TGGAAG 4 -- us2k10--------
    rs1409994141,2
    --21821465(+) GTTTGA/TAGCCC 4 -- us2k10--------
    rs1807333291,2
    C--21821484(+) TTCATA/TAATTT 4 -- us2k10--------
    rs1861683691,2
    --21821568(+) TCATAA/TTATGT 4 -- us2k10--------
    rs800082521,2
    F--21821574(+) TATGTA/TGTCTT 5 -- us2k11Minor allele frequency- T:0.01NA 120
    rs1910837121,2
    --21821682(+) AATTTA/GCTATA 5 -- us2k10--------

    HapMap Linkage Disequilibrium report for MLLT10 (21823094 - 22032559 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 9 variations for MLLT10:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2609802CNV Deletion19546169
    nsv825289CNV Loss20364138
    dgv622n71CNV Loss21882294
    nsv894947CNV Loss21882294
    dgv623n71CNV Loss21882294
    esv22595CNV Gain19812545
    dgv133n67CNV Gain20364138
    dgv135n67CNV Gain20364138
    dgv134n67CNV Gain20364138

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing MLLT10
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 602409   
    OMIM disorders: 601626  
    UniProtKB/Swiss-Prot: AF10_HUMAN, P55197
  • Note=A chromosomal aberration involving MLLT10 is associated with acute leukemias. Translocation
    t(10;11)(p12;q23) with KMT2A/MLL1. The result is a rogue activator protein
  • Note=A chromosomal aberration involving MLLT10 is associated with diffuse histiocytic lymphomas.
    Translocation t(10;11)(p13;q14) with PICALM

  • 3 diseases for MLLT10:    
    About MalaCards
    verrucous papilloma    acute biphenotypic leukemia    precursor t-cell acute lymphoblastic leukemia

    1 disease from the University of Copenhagen DISEASES database for MLLT10:
    Leukemia

    Find genes that share disorders with MLLT10           About GenesLikeMe

    Selected Novoseek inferred disease relationships for MLLT10 gene (see all 11)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    acute monocytic leukemia 75.4 1 7662954 (1)
    leukemogenesis 71.5 3 12461747 (1), 15851025 (1)
    t-all 67.7 3 16107895 (2), 16921363 (1)
    leukemia 66.1 20 16921363 (2), 10602503 (1), 9737689 (1), 11135434 (1) (see all 13)
    acute leukemia 56.8 1 11423977 (1)
    myeloid leukemia 55.4 5 9365832 (1), 8643484 (1), 20445327 (1)
    lymphoma large cell diffuse 54.8 1 9737689 (1)
    hematologic malignancies 50 3 11756182 (1), 9737689 (1), 15254754 (1)
    mediastinal mass 47.2 1 10221337 (1)
    lymphoblastic leukemia acute 45.8 2 9844603 (2)

    Genetic Association Database (GAD): MLLT10
    Human Genome Epidemiology (HuGE) Navigator: MLLT10 (3 documents)

    Export disorders for MLLT10 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for MLLT10 gene, integrated from 10 sources (see all 76):
    (articles sorted by number of sources associating them with MLLT10)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. A novel class of zinc finger/leucine zipper genes identified from the molecular cloning of the t(10;11) translocation in acute leukemia. (PubMed id 7888665)1, 2, 3 Chaplin T.... Young B.D. (Blood 1995)
    2. AF10-dependent transcription is enhanced by its interaction with FLRG. (PubMed id 17868029)1, 2, 9 Forissier S....Rimokh R. (Biol. Cell 2007)
    3. The MLL fusion partner AF10 binds GAS41, a protein that interacts with the human SWI/SNF complex. (PubMed id 11756182)1, 2, 9 Debernardi S.... Young B.D. (Blood 2002)
    4. The synovial sarcoma associated protein SYT interacts with the acute leukemia associated protein AF10. (PubMed id 11423977)1, 2, 9 de Bruijn D.R.... Geurts van Kessel A. (Oncogene 2001)
    5. Biochemical analyses of the AF10 protein: the extended LAP/PHD-finger mediates oligomerisation. (PubMed id 10860745)1, 2, 9 Linder B.... Saha V. (J. Mol. Biol. 2000)
    6. hDOT1L links histone methylation to leukemogenesis. (PubMed id 15851025)1, 2, 9 Okada Y.... Zhang Y. (Cell 2005)
    7. Common variation at 10p12.31 near MLLT10 influences meningioma risk. (PubMed id 21804547)1, 4 Dobbins S.E....Houlston R.S. (Nat. Genet. 2011)
    8. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PubMed id 20628086)1, 4 Bailey S.D....Anand S. (Diabetes Care 2010)
    9. The DNA sequence and comparative analysis of human chromosome 10. (PubMed id 15164054)1, 2 Deloukas P.... Rogers J. (Nature 2004)
    10. Alternative splicing in wild-type AF10 and CALM cDNAs and in AF10- CALM and CALM-AF10 fusion cDNAs produced by the t(10;11)(p13-14;q14- q21) suggests a potential role for truncated AF10 polypeptides. (PubMed id 9737689)1, 9 Silliman C.C.... Hunger S.P. (Leukemia 1998)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 8028 HGNC: 16063 AceView: MLLT10 Ensembl:ENSG00000078403 euGenes: HUgn8028
    ECgene: MLLT10 H-InvDB: MLLT10

    (According to HUGE)
    About This Section

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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for MLLT10 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for MLLT10 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

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    Patent Information for MLLT10 gene:
    Search GeneIP for patents involving MLLT10

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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