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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

MLLT10 Gene

protein-coding   GIFtS: 56
GCID: GC10P021825

Myeloid/Lymphoid Or Mixed-Lineage Leukemia (Trithorax Homolog,...

(Previous names: myeloid/lymphoid or mixed-lineage leukemia (trithorax (Drosophila)...)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Myeloid/Lymphoid Or Mixed-Lineage Leukemia (Trithorax Homolog,
Drosophila); Translocated To, 101 2
     Protein AF-102
AF102 3 5     Type I AF10 Protein2
ALL1-Fused Gene From Chromosome 10 Protein2 3     Type III AF10 Protein2
Myeloid/Lymphoid Or Mixed-Lineage Leukemia (Trithorax (Drosophila)
Homolog); Translocated To, 101
     Type IV AF10 Protein2

External Ids:    HGNC: 160631   Entrez Gene: 80282   Ensembl: ENSG000000784037   OMIM: 6024095   UniProtKB: P551973   

Export aliases for MLLT10 gene to outside databases

Previous GC identifers: GC10P021558 GC10P021973 GC10P021827 GC10P021863 GC10P021469


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for MLLT10 Gene:
This gene encodes a transcription factor and has been identified as a partner gene involved in several chromosomal
rearrangements resulting in various leukemias. Multiple transcript variants encoding different isoforms have been
found for this gene. (provided by RefSeq, Sep 2010)

GeneCards Summary for MLLT10 Gene: 
MLLT10 (myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 10) is a protein-coding gene. Diseases associated with MLLT10 include mediastinitis, and acute biphenotypic leukemia. GO annotations related to this gene include DNA binding and sequence-specific DNA binding transcription factor activity. An important paralog of this gene is PHF15.

UniProtKB/Swiss-Prot: AF10_HUMAN, P55197
Function: Probably involved in transcriptional regulation. In vitro or as fusion protein with KMT2A/MLL1 has
transactivation activity. Binds to cruciform DNA

Gene Wiki entry for MLLT10 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000010.10  NT_008705.16  NC_018921.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the MLLT10 gene promoter:
         POU3F1   HFH-1   Ik-3   Arnt   c-Ets-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidMLLT10 promoter sequence
   Search SABiosciences Chromatin IP Primers for MLLT10

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat MLLT10


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 10p12   Ensembl cytogenetic band:  10p12.31   HGNC cytogenetic band: 10p12

MLLT10 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
MLLT10 gene location

GeneLoc information about chromosome 10         GeneLoc Exon Structure

GeneLoc location for GC10P021825:  view genomic region     (about GC identifiers)

Start:
21,823,094 bp from pter      End:
22,032,559 bp from pter
Size:
209,466 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: AF10_HUMAN, P55197 (See protein sequence)
Recommended Name: Protein AF-10  
Size: 1068 amino acids; 113320 Da
Subunit: Self-associates. Interacts with FSTL3 isoform 2; the interaction enhances MLLT10 in vitro transcriptional
activity and self-association. Interacts with YEATS4. Interacts with SS18. Interacts with DOT1L; this interaction
also occurs with the KMT2A/MLL1 fusion protein
Subcellular location: Nucleus
Sequence caution: Sequence=BC129946; Type=Frameshift; Positions=235;
Secondary accessions: B1ANA8 Q5JT37 Q5VX90 Q66K63
Alternative splicing: 4 isoforms:  P55197-4   P55197-1   P55197-2   P55197-3   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for MLLT10: NX_P55197

Explore proteomics data for MLLT10 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_P55197

  • MLLT10 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    MLLT10 Protein Expression
    REFSEQ proteins (5 alternative transcripts): 
    NP_001182555.1  NP_001182556.1  NP_001182557.1  NP_001182559.1  NP_004632.1  

    ENSEMBL proteins: 
     ENSP00000366304   ENSP00000366272   ENSP00000307411   ENSP00000366295   ENSP00000397800  
     ENSP00000408281   ENSP00000399883   ENSP00000401406   ENSP00000366258  

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    Cloud-Clone Corp. Proteins for MLLT10 

    Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA--
    GO:0005730NOT nucleolus IDA--
    GO:0005737cytoplasm IDA--

    MLLT10 for ontologies           About GeneDecksing



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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    PHF: Zinc fingers, PHD-type

    5 InterPro protein domains:
     IPR001965 Znf_PHD
     IPR013083 Znf_RING/FYVE/PHD
     IPR019786 Zinc_finger_PHD-type_CS
     IPR011011 Znf_FYVE_PHD
     IPR019787 Znf_PHD-finger

    Graphical View of Domain Structure for InterPro Entry P55197

    ProtoNet protein and cluster: P55197

    1 Blocks protein domain: IPB001965 Zn-finger-like

    UniProtKB/Swiss-Prot: AF10_HUMAN, P55197
    Similarity: Contains 2 PHD-type zinc fingers


    MLLT10 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: AF10_HUMAN, P55197
    Function: Probably involved in transcriptional regulation. In vitro or as fusion protein with KMT2A/MLL1 has
    transactivation activity. Binds to cruciform DNA

         Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003677DNA binding IEA--
    GO:0003700sequence-specific DNA binding transcription factor activity NAS7888665
    GO:0005515protein binding IPI17868029
    GO:0008270zinc ion binding IEA--
         
    MLLT10 for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for MLLT10:
     Increased gamma-H2AX phosphory 

    Animal Models:
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    SwitchGear 3'UTR luciferase reporter plasmidMLLT10 3' UTR sequence
    Inhib. RNA
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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section



    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for MLLT10

    STRING Interaction Network Preview (showing 5 interactants - click image to see 19)

    5/23 Interacting proteins for MLLT10 (P551973 ENSP000003662724) via UniProtKB, MINT, STRING, and/or I2D (see all 23)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    RGPD5Q996663, ENSP000000169464I2D: score=1 STRING: ENSP00000016946
    DOT1LQ8TEK33, ENSP000003816574I2D: score=2 STRING: ENSP00000381657
    NDEL1Q9GZM83, ENSP000003339824I2D: score=2 STRING: ENSP00000333982
    SS18Q155323, ENSP000002691384I2D: score=2 STRING: ENSP00000269138
    MLLT3P425683, ENSP000003696954I2D: score=1 STRING: ENSP00000369695
    About this table

    Gene Ontology (GO): 2 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006351transcription, DNA-dependent IEA--
    GO:0045944positive regulation of transcription from RNA polymerase II promoter IDA17868029

    MLLT10 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    MLLT10 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for MLLT10 (AF10)

    3 Novoseek inferred chemical compound relationships for MLLT10 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    af 10 99.3 144 9737689 (7), 11756182 (5), 10221337 (5), 17868029 (5) (see all 40)
    leucine 56.1 10 7662954 (3), 11756182 (2), 12482966 (2), 10602503 (1) (see all 6)
    zinc 12 3 11756182 (1), 7568208 (1), 7662954 (1)

    Search CenterWatch for drugs/clinical trials and news about MLLT10 / AF10

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for MLLT10 gene (6 alternative transcripts): 
    NM_001195626.1  NM_001195627.1  NM_001195628.1  NM_001195630.1  NM_004641.3  NM_001009569.1  

    Unigene Cluster for MLLT10:

    Myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 10
    Hs.30385  [show with all ESTs]
    Unigene Representative Sequence: AB209755
    16 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000377100(uc001iqr.2 uc001iqu.2 uc001iqq.2) ENST00000377072(uc001iqs.3 uc001iqv.3 uc001iqt.3)
    ENST00000307729(uc021pny.1 uc001ira.3 uc001irb.3) ENST00000377091
    ENST00000471315 ENST00000495130(uc001iqx.1 uc009xkf.1 uc009xke.1 uc001iqw.1)
    ENST00000476557 ENST00000430455 ENST00000462999 ENST00000480415 ENST00000479634
    ENST00000438473 ENST00000468309 ENST00000420525 ENST00000446906 ENST00000377059

    miRNA
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    8/49 QIAGEN miScript miRNA Assays for microRNAs that regulate MLLT10 (see all 49):
    hsa-miR-300 hsa-let-7d hsa-miR-128 hsa-miR-139-5p hsa-let-7a-2* hsa-miR-301a hsa-miR-10b* hsa-miR-374c
    SwitchGear 3'UTR luciferase reporter plasmidMLLT10 3' UTR sequence
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    Additional mRNA sequence: 

    AB209755.1 AF060927.1 AF060929.1 AF060932.1 AF060934.1 AF060935.1 AF060936.1 AF060937.1 
    AF060938.1 AF272385.1 AK126642.1 AK301213.1 AK310803.1 AL137295.1 AY598745.1 BC032532.1 
    BC052798.1 BC065376.1 BC080577.1 BC094844.1 BC129946.1 BX640774.1 BX648210.1 U13948.1 

    19 DOTS entries:

    DT.416343  DT.101980714  DT.95172977  DT.95172979  DT.101977940  DT.91741124  DT.121300683  DT.92471719 
    DT.40118519  DT.100764476  DT.107987  DT.121300612  DT.121300661  DT.75135685  DT.101968555  DT.121300666 
    DT.100823172  DT.309851  DT.87017228 

    24/220 AceView cDNA sequences (see all 220):

    BM670709 AI362588 BU931245 AA708915 Z39947 BX109927 F03170 AI198634 
    AF060938 BM711458 BC052798 AL044723 AL046668 BG283694 AF060935 AI187961 
    AI656923 BQ056555 AF060934 AI147420 CR591323 BC032532 BM460738 BU617758 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    MLLT10 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TATTAAAATG
    MLLT10 Expression
    About this image


    See MLLT10 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for MLLT10

    SOURCE GeneReport for Unigene cluster: Hs.30385

    UniProtKB/Swiss-Prot: AF10_HUMAN, P55197
    Tissue specificity: Expressed abundantly in testis

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    In Situ
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals and fungi.

    Orthologs for MLLT10 gene from 7/15 species (see all 15)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Mllt101 , 5 myeloid/lymphoid or mixed-lineage leukemia (trithorax more1, 5 90.45(n)1
    93.43(a)1
      2 (12.84 cM)5
    173541  NM_001252560.11  NP_001239489.11 
     180643945 
    chicken
    (Gallus gallus)
    Aves MLLT101 myeloid/lymphoid or mixed-lineage leukemia (trithorax more 84.76(n)
    87.17(a)
      420509  XM_418610.3  XP_418610.3 
    lizard
    (Anolis carolinensis)
    Reptilia MLLT106
    myeloid/lymphoid or mixed-lineage leukemia (tritho...
    77(a)
    1 ↔ 1
    6(16561580-16710014)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia Str.162972 Transcribed sequence with moderate similarity to protein more 79.48(n)    BX701108.1 
    zebrafish
    (Danio rerio)
    Actinopterygii mllt101 myeloid/lymphoid or mixed-lineage leukemia (trithorax more 71.01(n)
    77.64(a)
      492342  XM_003201290.1  XP_003201338.1 
    worm
    (Caenorhabditis elegans)
    Secernentea zfp-13 Expression: intestine, pharynx, phasmid
    sensilla, more
    59(a)   III(8864569-8866029)   --
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes NTO16
    Subunit of the NuA3 histone acetyltransferase comp...
    12(a)
    1 → many
    XVI(631515-633761)


    ENSEMBL Gene Tree for MLLT10 (if available)
    TreeFam Gene Tree for MLLT10 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for MLLT10 gene
    PHF152  PHF142  PHF172  BRD12  PHF162  BRPF12  MLLT62  BRPF32  
    7 SIMAP similar genes for MLLT10 using alignment to 5 protein entries:     AF10_HUMAN (see all proteins):
    MLL/AF10 fusion    AF10    DKFZp686E10210    DKFZp779J0967    PHF15    MLLT6
    BRPF3

    MLLT10 for paralogs           About GeneDecksing


    4 Pseudogenes.org Pseudogenes for MLLT10
    PGOHUM00000259181 PGOHUM00000262355 PGOHUM00000247503 PGOHUM00000245795


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/3829 SNPs in MLLT10 are shown (see all 3829)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 10 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1436568001,2
    C--21821147(+) AGGAAA/GTAGCA 4 -- us2k10--------
    rs1862903191,2
    --21821154(+) AGCAAA/GTGTTT 4 -- us2k10--------
    rs1910725281,2
    --21821220(+) ATACAA/GATTAA 4 -- us2k10--------
    rs70844541,2
    C,F,A,H--21821274(+) AATGTG/ATTTTT 4 -- us2k112Minor allele frequency- A:0.28NS EA NA WA CSA 668
    rs1480790731,2
    --21821322(+) GGGAGG/TGGAAG 4 -- us2k10--------
    rs1409994141,2
    --21821465(+) GTTTGA/TAGCCC 4 -- us2k10--------
    rs1807333291,2
    C--21821484(+) TTCATA/TAATTT 4 -- us2k10--------
    rs1861683691,2
    --21821568(+) TCATAA/TTATGT 4 -- us2k10--------
    rs800082521,2
    F--21821574(+) TATGTA/TGTCTT 5 -- us2k11Minor allele frequency- T:0.01NA 120
    rs1910837121,2
    --21821682(+) AATTTA/GCTATA 5 -- us2k10--------

    HapMap Linkage Disequilibrium report for MLLT10 (21823094 - 22032559 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 9 variations for MLLT10:    About this table     
    Variant IDTypeSubtypePubMed ID
    esv2609802CNV Deletion19546169
    nsv825289CNV Loss20364138
    dgv622n71CNV Loss21882294
    nsv894947CNV Loss21882294
    dgv623n71CNV Loss21882294
    esv22595CNV Gain19812545
    dgv133n67CNV Gain20364138
    dgv135n67CNV Gain20364138
    dgv134n67CNV Gain20364138

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 602409   
    OMIM disorders: 601626  
    UniProtKB/Swiss-Prot: AF10_HUMAN, P55197
  • Note=A chromosomal aberration involving MLLT10 is associated with acute leukemias. Translocation
    t(10;11)(p12;q23) with KMT2A/MLL1. The result is a rogue activator protein
  • Note=A chromosomal aberration involving MLLT10 is associated with diffuse histiocytic lymphomas.
    Translocation t(10;11)(p13;q14) with PICALM

  • 15 diseases for MLLT10:    About MalaCards
    mediastinitis    acute biphenotypic leukemia    acute monocytic leukemia    monocytic leukemia
    leukemia    acute leukemia    synovial sarcoma    lymphoblastic leukemia
    acute myeloid leukemia    myeloid leukemia    acute lymphoblastic leukemia    retinoblastoma
    sarcoma    myeloma    schizophrenia

    1 disease from the University of Copenhagen DISEASES database for MLLT10:
    Leukemia

    MLLT10 for disorders           About GeneDecksing

    10/11 Novoseek inferred disease relationships for MLLT10 gene (see all 11)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    acute monocytic leukemia 75.4 1 7662954 (1)
    leukemogenesis 71.5 3 12461747 (1), 15851025 (1)
    t-all 67.7 3 16107895 (2), 16921363 (1)
    leukemia 66.1 20 16921363 (2), 10602503 (1), 9737689 (1), 11135434 (1) (see all 13)
    acute leukemia 56.8 1 11423977 (1)
    myeloid leukemia 55.4 5 9365832 (1), 8643484 (1), 20445327 (1)
    lymphoma large cell diffuse 54.8 1 9737689 (1)
    hematologic malignancies 50 3 11756182 (1), 9737689 (1), 15254754 (1)
    mediastinal mass 47.2 1 10221337 (1)
    lymphoblastic leukemia acute 45.8 2 9844603 (2)

    Genetic Association Database (GAD): MLLT10
    Human Genome Epidemiology (HuGE) Navigator: MLLT10 (3 documents)

    Export disorders for MLLT10 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for MLLT10 gene, integrated from 9 sources (see all 76):
    (articles sorted by number of sources associating them with MLLT10)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. A novel class of zinc finger/leucine zipper genes identified from the molecular cloning of the t(10;11) translocation in acute leukemia. (PubMed id 7888665)1, 2, 3 Chaplin T.... Young B.D. (1995)
    2. AF10-dependent transcription is enhanced by its interaction with FLRG. (PubMed id 17868029)1, 2, 9 Forissier S....Rimokh R. (2007)
    3. The MLL fusion partner AF10 binds GAS41, a protein that interacts with the human SWI/SNF complex. (PubMed id 11756182)1, 2, 9 Debernardi S.... Young B.D. (2002)
    4. The synovial sarcoma associated protein SYT interacts with the acute leukemia associated protein AF10. (PubMed id 11423977)1, 2, 9 de Bruijn D.R....Geurts van Kessel A. (2001)
    5. Biochemical analyses of the AF10 protein: the extended LAP/PHD-finger mediates oligomerisation. (PubMed id 10860745)1, 2, 9 Linder B.... Saha V. (2000)
    6. hDOT1L links histone methylation to leukemogenesis. (PubMed id 15851025)1, 2, 9 Okada Y.... Zhang Y. (2005)
    7. Common variation at 10p12.31 near MLLT10 influences m eningioma risk. (PubMed id 21804547)1, 4 Dobbins S.E....Houlston R.S. (2011)
    8. Variation at the NFATC2 locus increases the risk of t hiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipr il and rosiglitazone Medication (DREAM) study. (PubMed id 20628086)1, 4 Bailey S.D....Anand S. (2010)
    9. The DNA sequence and comparative analysis of human chromosome 10. (PubMed id 15164054)1, 2 Deloukas P.... Rogers J. (2004)
    10. Alternative splicing in wild-type AF10 and CALM cDNAs and in AF10- CALM and CALM-AF10 fusion cDNAs produced by the t(10;11)(p13-14;q14- q21) suggests a potential role for truncated AF10 polypeptides. (PubMed id 9737689)1, 9 Silliman C.C.... Hunger S.P. (1998)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 8028 HGNC: 16063 AceView: MLLT10 Ensembl:ENSG00000078403 euGenes: HUgn8028
    ECgene: MLLT10 H-InvDB: MLLT10

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for MLLT10 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for MLLT10 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for MLLT10 gene:
    Search GeneIP for patents involving MLLT10

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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