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MLLT1 Gene

protein-coding   GIFtS: 61
GCID: GC19M006210

Myeloid/Lymphoid Or Mixed-Lineage Leukemia (Trithorax Homolog,...

(Previous names: myeloid/lymphoid or mixed-lineage leukemia (trithorax (Drosophila)...)
  See MLLT1-related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Myeloid/Lymphoid Or Mixed-Lineage Leukemia (Trithorax Homolog,
Drosophila); Translocated To, 11 2
     CTC-503J8.62
ENL2 3 5     ENL/MLL Fusion2
LTG192 3     MLLT1/MLL Fusion2
YEATS12 3     Myeloid/Lymphoid Or Mixed-Lineage Leukemia (Trithorax Homolog);
Translocated To, 12
YEATS Domain-Containing Protein 12 3     Protein ENL2
Myeloid/Lymphoid Or Mixed-Lineage Leukemia (Trithorax (Drosophila)
Homolog); Translocated To, 11
     

External Ids:    HGNC: 71341   Entrez Gene: 42982   Ensembl: ENSG000001303827   OMIM: 1595565   UniProtKB: Q031113   

Export aliases for MLLT1 gene to outside databases

Previous GC identifers: GC19M006305 GC19M006152 GC19M006163 GC19M005969


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for MLLT1 Gene:
MLLT1 (myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 1) is a protein-coding gene. Diseases associated with MLLT1 include mitochondrial dna depletion syndrome 8a, and mitochondrial dna depletion syndrome. An important paralog of this gene is MLLT3.

UniProtKB/Swiss-Prot: ENL_HUMAN, Q03111
Function: Component of the super elongation complex (SEC), a complex required to increase the catalytic rate of
RNA polymerase II transcription by suppressing transient pausing by the polymerase at multiple sites along the
DNA

Gene Wiki entry for MLLT1 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000019.9  NT_011295.12  NC_018930.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the MLLT1 gene promoter:
         AML1a   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidMLLT1 promoter sequence
   Search Chromatin IP Primers for MLLT1

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat MLLT1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 19p13.3   Ensembl cytogenetic band:  19p13.3   HGNC cytogenetic band: 19p13.3

MLLT1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
MLLT1 gene location

GeneLoc information about chromosome 19         GeneLoc Exon Structure

GeneLoc location for GC19M006210:  view genomic region     (about GC identifiers)

Start:
6,210,392 bp from pter      End:
6,279,959 bp from pter
Size:
69,568 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: ENL_HUMAN, Q03111 (See protein sequence)
Recommended Name: Protein ENL  
Size: 559 amino acids; 62056 Da
Subunit: Component of the super elongation complex (SEC), at least composed of AFF4, the P-TEFb complex and ELL
(ELL, ELL2 or ELL3). Interacts with ALKBH4
Secondary accessions: Q14768

Explore the universe of human proteins at neXtProt for MLLT1: NX_Q03111

Explore proteomics data for MLLT1 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See MLLT1 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_005925.2  
    ENSEMBL proteins: 
     ENSP00000252674  

    MLLT1 Human Recombinant Protein Products:

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    antibodies-online peptides for MLLT1

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    1 InterPro protein domain:
     IPR005033 YEATS

    Graphical View of Domain Structure for InterPro Entry Q03111

    ProtoNet protein and cluster: Q03111

    1 Blocks protein domain: IPB005033 YEATS family

    UniProtKB/Swiss-Prot: ENL_HUMAN, Q03111
    Similarity: Contains 1 YEATS domain


    Find genes that share domains with MLLT1           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: ENL_HUMAN, Q03111
    Function: Component of the super elongation complex (SEC), a complex required to increase the catalytic rate of
    RNA polymerase II transcription by suppressing transient pausing by the polymerase at multiple sites along the
    DNA

         Genatlas biochemistry entry for MLLT1:
    serine/proline rich nuclear protein,fused with HRX (MLL) in acute lymphoblastic leukemia with translocation
    t(11;19)(q23;p13)

         Gene Ontology (GO): 2 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003677DNA binding TAS7991593
    GO:0005515protein binding IPI--
         
    Find genes that share ontologies with MLLT1           About GenesLikeMe


    Phenotypes:
         4 GenomeRNAi human phenotypes for MLLT1:
     Decreased BPV1 E2 protein expr  Decreased Salmonella enterica   Increased HPV18 LCR reporter a  Lamellipodia cells 

         7 MGI mutant phenotypes (inferred from 2 alleles(MGI details for Mllt1):
     hematopoietic system  immune system  liver/biliary system  mortality/aging  normal 
     renal/urinary system  tumorigenesis 

    Find genes that share phenotypes with MLLT1           About GenesLikeMe

    Animal Models:
         MGI mouse knock-out Mllt1tm1Dw for MLLT1

       genOway: Develop your customized and physiologically relevant rodent model for MLLT1

    miRNA
    Products:
        
    miRTarBase miRNAs that target MLLT1:
    hsa-mir-484 (MIRT041863), hsa-let-7b-5p (MIRT001617), hsa-mir-16-5p (MIRT001442)

    Block miRNA regulation of human, mouse, rat MLLT1 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate MLLT1 (see all 39):
    hsa-miR-607 hsa-miR-449a hsa-miR-520g hsa-miR-3163 hsa-miR-34c-5p hsa-miR-571 hsa-miR-449b hsa-miR-561
    SwitchGear 3'UTR luciferase reporter plasmidMLLT1 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat MLLT1

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    Browse Sino Biological Human cDNA Clones
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MLLT1

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    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MLLT1


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    ENL_HUMAN, Q03111: Nucleus
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus5
    cytosol3
    cytoskeleton1
    golgi apparatus1

    Gene Ontology (GO): 3 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA--
    GO:0005730NOT nucleolus IDA--
    GO:0005737cytoplasm IDA--

    Find genes that share ontologies with MLLT1           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for MLLT1 About    
    See pathways by source

    SuperPathContained pathways About
    1Transcriptional misregulation in cancer
    Transcriptional misregulation in cancer
    2Chromatin Regulation / Acetylation
    Chromatin Regulation / Acetylation


    Find genes that share SuperPaths with MLLT1           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 Cell Signaling Technology (CST) Pathway for MLLT1
        Chromatin Regulation / Acetylation


    1 Kegg Pathway  (Kegg details for MLLT1):
        Transcriptional misregulation in cancer

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for MLLT1
    Interactions:

        GeneGlobe Interaction Network for MLLT1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for MLLT1 (Q031111, 3 ENSP000002526744) via UniProtKB, MINT, STRING, and/or I2D (see all 176)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    AFF4Q9UHB71, 3, ENSP000002653434EBI-1384215,EBI-395282 I2D: score=4 STRING: ENSP00000265343
    DOT1LQ8TEK31, 3, ENSP000003816574EBI-1384215,EBI-2619253 I2D: score=2 STRING: ENSP00000381657
    ARID1AO144973, ENSP000003204854I2D: score=2 STRING: ENSP00000320485
    CCNT1O605633, ENSP000002619004I2D: score=2 STRING: ENSP00000261900
    ACACAQ130853, ENSP000003447894I2D: score=1 STRING: ENSP00000344789
    About this table

    Gene Ontology (GO): 3 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006355regulation of transcription, DNA-templated IEA--
    GO:0006366transcription from RNA polymerase II promoter TAS8080983
    GO:0006469negative regulation of protein kinase activity IEA--

    Find genes that share ontologies with MLLT1           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for MLLT1 (ENL)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for MLLT1 gene: 
    NM_005934.3  

    Unigene Cluster for MLLT1:

    Myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 1
    Hs.10095  [show with all ESTs]
    Unigene Representative Sequence: NM_005934
    2 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000252674(uc002mek.3) ENST00000585588
    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat MLLT1 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate MLLT1 (see all 39):
    hsa-miR-607 hsa-miR-449a hsa-miR-520g hsa-miR-3163 hsa-miR-34c-5p hsa-miR-571 hsa-miR-449b hsa-miR-561
    SwitchGear 3'UTR luciferase reporter plasmidMLLT1 3' UTR sequence
    Inhib. RNA
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      QuantiFast Probe-based Assays in human, mouse, rat MLLT1

    Additional mRNA sequence: 

    AF373587.1 AL365410.1 AY040555.1 BC047008.1 BC063667.1 BC084564.1 D14539.1 L04285.1 

    5 DOTS entries:

    DT.203140  DT.91766924  DT.95232410  DT.95190965  DT.95190967 

    11 AceView cDNA sequences:

    BF804272 L04285 BF848582 NM_005934 D14539 BF748184 AY040555 H94599 
    BE177544 BF355840 BF355931 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    MLLT1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GGCTCCCAAG
    MLLT1 Expression
    About this image


    MLLT1 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 2) fully expand
     
     Placenta (Extraembryonic Tissues)
             Syncytiotrophoblast-like cells
     
     Neural Tube (Nervous System)
             Metencephalon
    MLLT1 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    MLLT1 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.10095
        Custom PCR Arrays for MLLT1
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    In Situ
    Assay Products:
     

     
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for MLLT1 gene from Selected species (see all 12)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Mllt11 , 5 myeloid/lymphoid or mixed-lineage leukemia (trithorax more1, 5 86.11(n)1
    88.48(a)1
      17 (29.56 cM)5
    641441  NM_022328.21  NP_071723.11 
     568926125 
    chicken
    (Gallus gallus)
    Aves MLLT11 myeloid/lymphoid or mixed-lineage leukemia (trithorax more 78.32(n)
    86.16(a)
      420089  XM_418209.4  XP_418209.4 
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia Str.62232 Transcribed sequence with moderate similarity to protein more 78.64(n)    142031938 
    zebrafish
    (Danio rerio)
    Actinopterygii Dr.290842 Danio rerio cDNA clone IMAGE6793815, partial cds 77.98(n)    BC063028.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta ear3 transcription initiation from Pol II
    promoter more
    44(a)   88F1   --


    ENSEMBL Gene Tree for MLLT1 (if available)
    TreeFam Gene Tree for MLLT1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for MLLT1 gene
    MLLT32  
    3 SIMAP similar genes for MLLT1 using alignment to 1 protein entry:     ENL_HUMAN:
    DKFZp686D09204    MLLT3    LTG9/MLLT3

    Find genes that share paralogs with MLLT1           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for MLLT1 (see all 1646)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 19 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs583890221,2
    C--6206139(+) TTGTCA/GTTAAA 1 -- int14Minor allele frequency- G:0.16CSA WA NA EA 359
    rs607406031,2
    C,F--6206154(+) GGGTTG/ATCATT 1 -- int13Minor allele frequency- A:0.15WA NA EA 358
    rs1809771931,2
    --6206239(+) ACATGC/TGGCCA 1 -- int10--------
    rs1378763361,2
    C--6206240(+) CATGCA/GGCCAA 1 -- int10--------
    rs576732691,2
    C--6206279(+) TGATCA/GTTAGA 1 -- int10--------
    rs596850371,2
    C,F--6206338(+) ATGGCG/AATTAT 1 -- int13Minor allele frequency- A:0.16WA NA EA 358
    rs1415448151,2
    C--6209900(+) CCTCC-/TTTCCG 1 -- int10--------
    rs2009239871,2
    --6209903(+) TCCTT-/CCGTCCTT 1 -- int10--------
    rs1878540471,2
    --6209957(+) CCATCA/GATCCA 1 -- int10--------
    rs72562821,2
    C,F,H--6210058(+) atccaC/Ttcacc 1 -- int16Minor allele frequency- T:0.04NS EA CSA WA 532

    HapMap Linkage Disequilibrium report for MLLT1 (6210392 - 6279959 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 9 variations for MLLT1:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2666707CNV Deletion23128226
    esv2718064CNV Deletion23290073
    esv2662795CNV Deletion23128226
    esv991625CNV Deletion20482838
    esv2718063CNV Deletion23290073
    nsv2396CNV Insertion18451855
    nsv910910CNV Loss21882294
    nsv910911CNV Loss21882294
    dgv3697n71CNV Loss21882294

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing MLLT1
    DNA2.0 Custom Variant and Variant Library Synthesis for MLLT1

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 159556    OMIM disorders: --

    UniProtKB/Swiss-Prot: ENL_HUMAN, Q03111
  • Note=A chromosomal aberration involving MLLT1 is associated with acute leukemias. Translocation
    t(11;19)(q23;p13.3) with KMT2A/MLL1. The result is a rogue activator protein

  • 2 diseases for MLLT1:    
    About MalaCards
    mitochondrial dna depletion syndrome 8a    mitochondrial dna depletion syndrome

    3 diseases from the University of Copenhagen DISEASES database for MLLT1:
    Leprosy     Leukemia     Neuritis

    Find genes that share disorders with MLLT1           About GenesLikeMe

    2 Novoseek inferred disease relationships for MLLT1 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    acute leukemia 58.7 2 16990786 (1)
    leukemia 51.3 8 12367585 (3), 11520560 (1), 18347158 (1)

    Genetic Association Database (GAD): MLLT1
    Human Genome Epidemiology (HuGE) Navigator: MLLT1 (1 document)

    Export disorders for MLLT1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for MLLT1 gene, integrated from 10 sources (see all 53):
    (articles sorted by number of sources associating them with MLLT1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Two distinct portions of LTG19/ENL at 19p13 are involved in t(11;19) leukemia. (PubMed id 8378076)1, 2, 9 Yamamoto K.... Ueda R. (Oncogene 1993)
    2. Involvement of a homolog of Drosophila trithorax by 11q23 chromosomal translocations in acute leukemias. (PubMed id 1423624)1, 2, 9 Tkachuk D.C.... Cleary M.L. (Cell 1992)
    3. HIV-1 Tat and host AFF4 recruit two transcription elongation factors into a bifunctional complex for coordinated activation of HIV-1 transcription. (PubMed id 20471948)1, 2 He N.... Zhou Q. (Mol. Cell 2010)
    4. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (Mol. Med. 2010)
    5. Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PubMed id 17081983)1, 2 Olsen J.V....Mann M. (Cell 2006)
    6. ENL, the gene fused with HRX in t(11;19) leukemias, encodes a nuclear protein with transcriptional activation potential in lymphoid and myeloid cells. (PubMed id 8080983)1, 2 Rubnitz J.E.... Cleary M.L. (Blood 1994)
    7. Simultaneous localization of MLL, AF4 and ENL genes in interphase nuclei by 3D-FISH: MLL translocation revisited. (PubMed id 16433901)1, 9 GuAc M....Boudier T. (BMC Cancer 2006)
    8. A higher-order complex containing AF4 and ENL family proteins with P-TEFb facilitates oncogenic and physiologic MLL-dependent transcription. (PubMed id 20153263)1, 9 Yokoyama A....Cleary M.L. (Cancer Cell 2010)
    9. Interlaboratory reproducibility of large-scale human protein-complex analysis by standardized AP-MS. (PubMed id 23455922)1 Varjosalo M....Superti-Furga G. (Nat. Methods 2013)
    10. The protein interaction landscape of the human CMGC kinase group. (PubMed id 23602568)1 Varjosalo M....Gstaiger M. (Cell Rep 2013)

    (in PubMed, OMIM, and NCBI Bookshelf)
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 4298 HGNC: 7134 AceView: MLLT1 Ensembl:ENSG00000130382 euGenes: HUgn4298
    ECgene: MLLT1 Kegg: 4298 H-InvDB: MLLT1

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for MLLT1 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for MLLT1 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for MLLT1 gene:
    Search GeneIP for patents involving MLLT1

    GeneCards and IP:
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