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MLLT1 Gene

protein-coding   GIFtS: 59

GC19M006163
myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 1
(Previous names: myeloid/lymphoid or mixed-lineage leukemia (trithorax (Drosophila) homolog); translocated to, 1 )
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database
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Aliases &
Descriptions
for MLLT1

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc , and/or 7Ensembl, 8miRBase)
About This Section
Aliases
ENL 1, 2, 3, 5
LTG19 1, 2, 3
YEATS1 1, 2, 3
Descriptions
YEATS domain-containing protein 1 3
myeloid/lymphoid or mixed-lineage leukemia (trithorax
(Drosophila) homolog); translocated to, 1 1
myeloid/lymphoid or mixed-lineage leukemia (trithorax
homolog); translocated to, 1 2
myeloid/lymphoid or mixed-lineage leukemia (trithorax
homolog, Drosophila); translocated to, 1 2
External Ids
HGNC: 71341
Entrez Gene: 42982
UniProtKB: Q031113
Ensembl: ENSG000001303827
Search outside databases for aliases for MLLT1 gene

Previous GC identifers: GC19M006305 GC19M006152

Summaries
for MLLT1

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

UniProtKB/Swiss-Prot: ENL_HUMAN, Q03111
Function: Capable of activating transcription from synthetic reporter genes in both lymphoid and
myeloid cells

Gene Wiki entry for MLLT1

Genomic Location
for MLLT1

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
About This Section

 Genomic View:
UCSC Golden Path with GeneCards custom track

 Transcription factor binding sites upstream to the MLLT1 gene  

Entrez Gene cytogenetic band: 19p13.3   Ensembl cytogenetic band:  19p13.3   HGNC cytogenetic band: 19p13.3

MLLT1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 19         GeneLoc Exon Structure

GeneLoc location for GC19M006163:     (about GC identifiers)

Start:
 6,161,392 bp from pter
End:
 6,230,959 bp from pter
Size:
 69,568 bases
Orientation:
 minus strand
RefSeq DNA sequence:
NC_000019.8  NT_011255.14  

Proteins
for MLLT1

(According to 1UniProtKB, and/or Ensembl, Phosphorylation sites according to 2Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
About This Section

 UniProtKB/Swiss-Prot: ENL_HUMAN, Q03111 (See protein sequence)
Recommended Name: Protein ENL  
Size: 559 amino acids; 62056 Da
Subcellular location: Nucleus
Secondary accessions: Q14768

Post-translational modifications:

  • View phosphorylation sites using PhosphoSite2


    • REFSEQ proteins: NP_005925.2  

    ENSEMBL proteins: 
    ENSP00000252674 


    Human Recombinant Proteins 
    Browse Drug Discovery Central at Invitrogen for human recombinant proteins
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    Recombinant Proteins from Abcam (MLLT1)
    Human Recombinant Proteins from Abnova (MLLT1)
                    Browse Origene for full length recombinant human proteins expressed in human HEK293 cells 

    1 Gene Ontology (GO) cellular component term (links to tree view):

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634 nucleus TAS8080983
    About this table

    Antibodies for MLLT1: 
    Browse Antibodies Central at Invitrogen
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    Antibodies from Abcam (MLLT1), each with their AbpromiseSM
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    Assays for MLLT1: 
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    Protein Domains/
    Families
    for MLLT1

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    1 InterPro domain/family:
     IPR005033 YEATS


       GeneDecks  MLLT1 for the domains selected above  
    About GeneDecksing

    Graphical View of Domain Structure for InterPro Entry Q03111

    ProtoNet protein and cluster: Q03111

    1 Blocks protein family: IPB005033 YEATS family

    UniProtKB/Swiss-Prot: ENL_HUMAN, Q03111
    Similarity: Contains 1 YEATS domain

    Gene Function
    for MLLT1

    (According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
    shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
    RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
    About This Section
    Inhib.
    RNA:    		Invitrogen RNAi Products for gene knock-down (MLLT1)
    Browse for Gene Knock-down Tools from Millipore
    Abnova Chimera RNAi Products for Gene knock-down (MLLT1)
                  OriGene 29mer shRNA kit in GFP-retroviral vector: NM_005934

                  Applied Biosystems Silencer® siRNAs for MLLT1

                  Sigma-Aldrich siRNA for MLLT1  
                         Sigma-Aldrich shRNA for MLLT1  
                         Explore Sigma-Aldrich super-pooled esiRNAs  

    Clones:Browse Clone Ranger at Invitrogen for clones
    Browse Clones for the Expression of Recombinant Proteins Available from Millipore
                  OriGene GFP tagged cDNA clone in CMV expression vector: NM_005934
                                     Myc/DDK tagged cDNA clone in CMV expression vector: NM_005934
                                     untagged cDNA clone in CMV expression vector: NM_005934 

    Primers: Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers
                  OriGene genome-wide validated SYBR primer pairs: NM_005934

    UniProtKB/Swiss-Prot: ENL_HUMAN, Q03111
    Function: Capable of activating transcription from synthetic reporter genes in both lymphoid and
    myeloid cells

    Genatlas biochemistry entry for MLLT1:
    serine/proline rich nuclear protein,fused with HRX (MLL) in acute lymphoblastic leukemia with
    translocation t(11;19)(q23;p13)

    8 MGI mutant phenotypes (inferred from 2 alleles) (MGI details for Mllt1):

    hematopoietic systemimmune systemlethality-prenatal/perinatallife span-post-weaning/agingliver/biliary system
    normalrenal/urinary systemtumorigenesis

    3 Gene Ontology (GO) molecular function terms (links to tree view):

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003677 DNA binding TAS7991593
    GO:0003702 RNA polymerase II transcription factor activity TAS8080983
    GO:0005515 protein binding IEA--
    About this table

    Pathways & Interactions
    for MLLT1

    (Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
    Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to 1UniProtKB, 2MINT, and/or 3STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
    About This Section


     Gene Network CentralTM Interacting Genes and Proteins Network for  MLLT1 


    5/12 Interacting proteins for MLLT1 (ENSP000002526743) via UniProtKB, MINT, and/or STRING (see all 12 )
    InteractantInteraction Details
    GeneCardExternal ID(s)
    AFF1ENSP000003056893STRING (score=.997)
    AFF4ENSP000003428063STRING (score=.971)
    MLLENSP000003741583STRING (score=.964)
    MLLT10ENSP000003074113STRING (score=.959)
    MLLT4ENSP000002526923STRING (score=.921)
    About this table

    4 Gene Ontology (GO) biological process terms (links to tree view):

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006350 transcription IEA--
    GO:0006355 regulation of transcription, DNA-dependent IEA--
    GO:0006366 transcription from RNA polymerase II promoter TAS8080983
    GO:0006469 negative regulation of protein kinase activity IEA--
    About this table

    Drugs & Compounds
    for MLLT1

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
    About This Section

    Browse drugs & compounds from Enzo Life Sciences
    Browse Small Molecules at Sigma-Aldrich

    Browse Tocris compounds for MLLT1

    Transcripts
    for MLLT1

    (GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView,
    non coding RNAs according to RNAdb,
    ESTs according to GeneTide,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from Invitrogen, Millipore, and/or Abnova,
    siRNAs from Applied Biosystems, Sigma-Aldrich,
    shRNA from Sigma-Aldrich, OriGene,
    Tagged/untagged cDNA clones from OriGene,
    Expression Assays from Applied Biosystems)
    About This Section
    Inhib.
    RNA:    		Invitrogen RNAi Products for gene knock-down (MLLT1)
    Browse for Gene Knock-down Tools from Millipore
    Abnova Chimera RNAi Products for Gene knock-down (MLLT1)
                  OriGene 29mer shRNA kit in GFP-retroviral vector: NM_005934

                  Sigma-Aldrich siRNA for MLLT1  
                         Sigma-Aldrich shRNA for MLLT1  
                         Explore Sigma-Aldrich super-pooled esiRNAs  

    Applied Biosystems Silencer® siRNAs: 

    NM_005934  

    REFSEQ mRNAs for MLLT1 gene: 

    NM_005934.3   

    Applied Biosystems TaqMan ® Gene Expression Assays: 

    NM_005934  

                  OriGene GFP tagged cDNA clone in CMV expression vector: NM_005934
                                     Myc/DDK tagged cDNA clone in CMV expression vector: NM_005934
                                     untagged cDNA clone in CMV expression vector: NM_005934 

    Additional cDNA sequence: 

    AF373587.1 AL365410.1 AY040555.1 BC047008.1 BC063667.1 BC084564.1 CR594829.1 CR598170.1 
    D14539.1 L04285.1 

    5 DOTS entries:

    DT.203140  DT.91766924  DT.95232410  DT.95190965  DT.95190967 

    11 AceView cDNA sequences:

    BF804272 L04285 BF848582 NM_005934 D14539 BF748184 AY040555 H94599 
    BE177544 BF355840 BF355931 

    highest scoring ESTs for MLLT1:

    D14539 BE177544 BF355840 BF748184 BF804272 BF848582 L04285 NM_005934 AW797028 AY040555 

    Unigene Cluster for MLLT1:

    Myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 1
    Hs.10095  [show with all ESTs]
    Unigene Representative Sequence: NM_005934


    GeneLoc Exon Structure

    1 Ensembl transcript including schematic representation:
    ENST00000252674  

    Expression
    for MLLT1

    (Experimental results according to 1GeneNote and GNF BioGPS,
    probe sets-to-genes annotations according to 2GeneAnnot , 3GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
    Expression Assays from Applied Biosystems )
    About This Section

    MLLT1 expression in normal and diseased human tissues

     Applied Biosystems TaqMan ® Gene Expression Assays for MLLT1

    1 / 2 / 3

    7 probe-sets matching MLLT1 gene


    		Affymetrix
    probe-set    		 Array  GeneAnnot data GeneNote data GeneTide data
    # genes Sensitivity Specificity Correlation Length Gb_Accession Consensus Uniqueness Score Rank

    		32400_at2, 3 U95-A 1 1.00 1.00 0.69 0.64 D14539 1.00 1.00 1.00 1

    		58879_at2, 3 U95-C 2 1.00 0.50 0.89 1.28 AI350917 0.40 0.75 0.60 1

    		55750_at2, 3 U95-B 2 1.00 0.50 0.86 1.08 R71228 0.40 0.75 0.60 1

    		214477_at2, 3 U133-A 1 1.00 1.00 -- -- NM_005934 0.60 1.00 0.82 1

    		224993_at2, 3 U133-B 2 1.00 0.50 -- -- AW962605 0.20 1.00 0.72 1

    		214477_at2 U133Plus2 1 1.00 1.00 -- -- -- -- -- -- --

    		224993_at2 U133Plus2 2 1.00 0.50 -- -- -- -- -- -- --
    About this table
    Data from (Publications) and GNF BioGPS
        About these images
    About these images

    CGAP SAGE TAG: GGCTCCCAAG

    SOURCE GeneReport for Unigene cluster: Hs.10095

    Expression variation in blood from EXPOLDB for MLLT1

    Orthologs
    for MLLT1

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD and/or 5MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
    About This Section
    Orthologs for MLLT1 gene from 5/9 species (see all 9 )
    Organism Gene Locus Description Human
    Similarity    		 NCBI accessions
    dog
    (Canis familiaris)    		 MLLT11   -- myeloid/lymphoid or mixed-lineage leukemia (trithorax more 88.91(n)
    89.96(a)    		 485023  XM_542141.2  XP_542141.2 
    chimpanzee
    (Pan troglodytes)    		 MLLT11   -- myeloid/lymphoid or mixed-lineage leukemia (trithorax more 99.01(n)
    99.08(a)    		 740990  XM_001143317.1  XP_001143317.1 
    cow
    (Bos taurus)    		 MLLT11   -- myeloid/lymphoid or mixed-lineage leukemia (trithorax more 89.69(n)
    91.86(a)    		 504458  XM_580591.3  XP_580591.2 
    rat
    (Rattus norvegicus)    		 Mllt11   -- myeloid/lymphoid or mixed-lineage leukemia (trithorax more 86.17(n)
    88.3(a)    		 301119  XM_238569.4  XP_238569.3 
    mouse
    (Mus musculus)    		 Mllt11, 5 175
    		 myeloid/lymphoid or mixed-lineage leukemia (trithorax more1, 5 86.11(n)1
    88.48(a)1    		 641441  NM_022328.21  NP_071723.11 
     AA4079015  AA6920745  (see all 29)
    About this table        Species with no ortholog for MLLT1

    ENSEMBL Gene Tree for MLLT1

    Paralogs
    for MLLT1

    (Paralogs according to 1HomoloGene
    and 2Ensembl, Pseudogenes according to 3Pseudogene.org)
    About This Section

    Paralogs for MLLT1 gene
    MLLT32  

    SNPs/Variants
    for MLLT1

    (According to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
    About This Section


    10/350 NCBI SNPs in MLLT1 are shown (see all 350 )
    (Click for Applied Biosystems TaqMan ® Genotyping Assay)  (see all 134)
    ABGenomic DataTranscription DataAllele Frequencies
    SNP IDValidChr 19 posSequenceRecsAA
    Chg    		TypeMoreRecsAllele
    freq    		PopTotal
    sample    		More
    ------------
    rs118810341,2
    		A,C,F,H6232607(+) agcaaC/Ttagga 1 -- ng318Minor allele frequency- T:0.30EU EA WA 836
    --
    rs72594021,2
    		F,H6231531(+) tgtacT/Cagcac 1 -- ng314Minor allele frequency- C:0.01EU EA WA 418
    rs118801011,2
    		C6173353(+) CTTGGC/TGCTGG 1 A/T mis1 ese30--------
    rs22331881,2
    		C,F,H6181692(-) TACGAC/TCTGTT 1 D/D syn1 ese311Minor allele frequency- T:0.09EU EA WA NA 980
    rs22331891,2
    		F,H6181662(-) CCGCCC/TGTGAA 1 P/P syn1 ese34Minor allele frequency- T:0.01EU EA WA 414
    rs22331871,2
    		H6181698(-) TTCACC/GTACGA 1 T/T syn1 ese34Minor allele frequency- G:0.00EU EA WA 418
    rs8920601,2
    		A,C,F,H,O6226910(+) CAGGGG/ACCCAC 1 -- int113Minor allele frequency- A:0.14NA EA EU WA 1072
    rs15606941,2
    		A,C,F,H,O6218827(+) CAAAAA/GGAGGG 1 -- int1 trp310Minor allele frequency- G:0.48EA NA EU WA 874
    rs37870621,2
    		A,C,F,H6180287(-) CCGGCG/TTGGGC 1 -- int14Minor allele frequency- T:0.49EU EA WA 414
    rs48078521,2
    		A,C,F,H6189183(+) AAAGAC/TGTATG 1 -- int118Minor allele frequency- T:0.37EU EA WA NA 1656
    About this table

    HapMap Linkage Disequilibrium images for MLLT1 (up to first 250kb)

    Disorders & Mutations
    for MLLT1

    (in which this Gene is Involved, According to OMIM, UniProtKB, Novoseek, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
    About This Section

    		 OMIM: 159556

    UniProtKB/Swiss-Prot: ENL_HUMAN, Q03111
  • A chromosomal aberration involving MLLT1 is associated with acute leukemias. Translocation
    t(11;19)(q23;p13.3) with MLL/HRX. The result is a rogue activator protein

    • 2 Novoseek disease relationships for MLLT1 gene

    Disease   Score   Articles   PubMed IDs for Articles with Shared Sentences (# sentences)
    acute leukemia 61.51 2 16990786 (1)
    leukemia 54.30 8 12367585 (3), 11520560 (1), 18347158 (1)
    About this table

    Medical News
    for MLLT1

    (Possibly Related Articles in Doctor's Guide)
    About This Section

    		   --

    Publications
    for MLLT1

    (in PubMed. Associations of this gene to articles via 1Novoseek, 2HGNC, 3Entrez Gene, 4UniProtKB/Swiss-Prot, 5UniProtKB/TrEMBL, 6GAD, and/or 7PharmGKB)
    About This Section

    		10/21 PubMed articles for MLLT1 gene (see all 21 ):

    Search for MLLT1

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section

     ANDOR
    Aliases
    Free Text  
      Query String
    		PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    Genome Databases showing MLLT1

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
    About This Section
    Entrez Gene: 4298 HGNC: 7134 AceView: MLLT1 Ensembl:ENSG00000130382 euGenes: HUgn4298
    ECgene: MLLT1 H-InvDB: MLLT1

    Other Databases showing MLLT1

    (According to HUGE)
    About This Section

    		   --

    Specialized Databases showing MLLT1

    (According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    ATLAS Chromosomes in Cancer entry for MLLT1 Genetics and Cytogenetics in Oncology and Haematology

    Licensable Technologies
    for MLLT1

    (Available from WIS Yeda, Salk, Tufts)
    About This Section

    		  --

    Services
    for MLLT1

    (Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
    Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
    Enzo Life Sciences, and/or Tocris Bioscience)
    About This Section



    Products for MLLT1:
     TaqMan ® Gene Expression Assays
     TaqMan ® Genotyping Assays
    		  Free SNP selection tool



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     Predesigned and custom siRNAs for MLLT1 Antibodies for MLLT1
     Explore super-pooled esiRNAs Browse proteins at Sigma-Aldrich
     Lentivirus-delivered shRNAs for MLLT1 Browse small molecules at Sigma-Aldrich
     "Your Favorite Gene" Pathwaysfeedback


      
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     Antibodies for MLLT1

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