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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

MLLT1 Gene

protein-coding   GIFtS: 59
GCID: GC19M006210

myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog,...

(Previous names: myeloid/lymphoid or mixed-lineage leukemia (trithorax (Drosophila)...)
 Explore 10 diseases affiliated with
MLLT1 via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for MLLT1    

Aliases
for MLLT1 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
Myeloid/Lymphoid Or Mixed-Lineage Leukemia (Trithorax Homolog, Drosophila);
Translocated To, 11 2
     Myeloid/Lymphoid Or Mixed-Lineage Leukemia (Trithorax (Drosophila) Homolog);
Translocated To, 11
ENL1 2 3 5     ENL/MLL Fusion2
LTG191 2 3     MLLT1/MLL Fusion2
YEATS11 2 3     Myeloid/Lymphoid Or Mixed-Lineage Leukemia (Trithorax Homolog); Translocated
To, 12
YEATS Domain-Containing Protein 12 3     Protein ENL2

External Ids:    HGNC: 71341   Entrez Gene: 42982   Ensembl: ENSG000001303827   OMIM: 1595565   UniProtKB: Q031113   

Export aliases for MLLT1 gene to outside databases

Previous GC identifers: GC19M006305 GC19M006152 GC19M006163 GC19M005969


Summaries
for MLLT1 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
UniProtKB/Swiss-Prot: ENL_HUMAN, Q03111
Function: Component of the super elongation complex (SEC), a complex required to increase the catalytic rate of RNA
polymerase II transcription by suppressing transient pausing by the polymerase at multiple sites along the DNA

Gene Wiki entry for MLLT1


Genomic Views
for MLLT1 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000019.9  NC_018930.1  NT_011255.14  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the MLLT1 gene promoter:
         AML1a   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: MLLT1 promoter sequence
   Search SABiosciences Chromatin IP Primers for MLLT1

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat MLLT1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 19p13.3   Ensembl cytogenetic band:  19p13.3   HGNC cytogenetic band: 19p13.3

MLLT1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
MLLT1 gene location

GeneLoc information about chromosome 19         GeneLoc Exon Structure

GeneLoc location for GC19M006210:  view genomic region     (about GC identifiers)

Start:
 6,210,392 bp from pter      End:
 6,279,959 bp from pter
Size:
 69,568 bases      Orientation:
 minus strand

Proteins
for MLLT1 gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: ENL_HUMAN, Q03111 (See protein sequence)
Recommended Name: Protein ENL  
Size: 559 amino acids; 62056 Da
Subunit: Component of the super elongation complex (SEC), at least composed of AFF4, the P-TEFb complex and ELL (ELL,
ELL2 or ELL3)
Subcellular location: Nucleus
Secondary accessions: Q14768

Explore the universe of human proteins at neXtProt for MLLT1: NX_Q03111

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q03111

    • MLLT1 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins: NP_005925.2  
    ENSEMBL proteins: 
     ENSP00000252674  

    Human Recombinant Protein Products: 
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    OriGene Protein Over-expression Lysate: MLLT1
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    Novus Biologicals MLLT1 Protein
    Novus Biologicals MLLT1 Lysate
    Browse Sino Biological Recombinant Proteins
    Browse ProSpec Recombinant Proteins
    Uscn Proteins for MLLT1

    Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA--
    GO:0005730NOT nucleolus IDA--
    GO:0005737cytoplasm IDA--


    MLLT1 for ontologies           About GeneDecksing



    MLLT1 Antibody Products: 
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    Uscn ELISAs and CLIAs for MLLT1

    Protein Domains /
    Families
    for MLLT1 gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    MLLT1 for domains           About GeneDecksing

    1 InterPro domain/family:
     IPR005033 YEATS

    Graphical View of Domain Structure for InterPro Entry Q03111

    ProtoNet protein and cluster: Q03111

    1 Blocks protein family: IPB005033 YEATS family

    UniProtKB/Swiss-Prot: ENL_HUMAN, Q03111
    Similarity: Contains 1 YEATS domain


    Function
    for MLLT1 gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: ENL_HUMAN, Q03111
    Function: Component of the super elongation complex (SEC), a complex required to increase the catalytic rate of RNA
    polymerase II transcription by suppressing transient pausing by the polymerase at multiple sites along the DNA

         Genatlas biochemistry entry for MLLT1:
    serine/proline rich nuclear protein,fused with HRX (MLL) in acute lymphoblastic leukemia with translocation
    t(11;19)(q23;p13)

    miRNA
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    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat MLLT1
    8/39 QIAGEN miScript miRNA Assays for microRNAs that regulate MLLT1 (see all 39):
    hsa-miR-607 hsa-miR-449a hsa-miR-520g hsa-miR-3163 hsa-miR-34c-5p hsa-miR-571 hsa-miR-449b hsa-miR-561
    SwitchGear 3'UTR luciferase reporter plasmid: MLLT1 3' UTR sequence
    Inhib. RNA
    Products:            		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for MLLT1 (see all 7)
    OriGene shRNA RFP: MLLT1
    OriGene siRNA: MLLT1
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat MLLT1

    Gene Editing
    Products:    		DNA2.0 Custom Protein Engineering Service for MLLT1

    Clone
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MLLT1 

    Cell Line
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    Search LifeMap BioReagents cell lines for MLLT1

    In Situ Assay
    Products:       
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MLLT1

    Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003677DNA binding TAS7991593
    GO:0005515protein binding IPI--


    MLLT1 for ontologies           About GeneDecksing


    4 GenomeRNAi human phenotypes for MLLT1:
     Decreased BPV1 E2 protein expr  Decreased Salmonella enterica   Increased HPV18 LCR reporter a  Lamellipodia cells 

    Animal Models:
         Mouse knock-out Mllt1tm1Dw for MLLT1
         7 MGI mutant phenotypes (inferred from 2 alleles) (MGI details for Mllt1):
     hematopoietic system  immune system  liver/biliary system  mortality/aging  normal 
     renal/urinary system  tumorigenesis 

    MLLT1 for phenotypes           About GeneDecksing


    Pathways & Interactions
    for MLLT1 gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways  About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1Chromatin Regulation / Acetylation
    		Chromatin Regulation / Acetylation1.00

    Pathway sources
    See GeneCards unified pathways
    Show all pathways


    1 Cell Signaling Technology (CST) Pathway for MLLT1
        Chromatin Regulation / Acetylation



    MLLT1 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for MLLT1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/30 Interacting proteins for MLLT1 (Q031111, 3 ENSP000002526744) via UniProtKB, MINT, STRING, and/or I2D (see all 30)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    DOT1LQ8TEK31, 3, ENSP000003816574EBI-1384215,EBI-2619253 I2D: score=2 STRING: ENSP00000381657
    AFF4Q9UHB71, 3, ENSP000002653434EBI-1384215,EBI-1384303 I2D: score=4 STRING: ENSP00000265343
    ARID1AO144973, ENSP000003204854I2D: score=2 STRING: ENSP00000320485
    CCNT1O605633, ENSP000002619004I2D: score=2 STRING: ENSP00000261900
    ACACAQ130853, ENSP000003447894I2D: score=1 STRING: ENSP00000344789
    About this table

    Gene Ontology (GO): 3 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006355regulation of transcription, DNA-dependent IEA--
    GO:0006366transcription from RNA polymerase II promoter TAS8080983
    GO:0006469negative regulation of protein kinase activity IEA--


    MLLT1 for ontologies           About GeneDecksing



    Drugs & Compounds
    for MLLT1 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for MLLT1
    Search CenterWatch for drugs/clinical trials and news about MLLT1 / ENL 

    Transcripts
    for MLLT1 gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for MLLT1 gene: 
    NM_005934.3  

    Unigene Cluster for MLLT1:

    Myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 1
    Hs.10095  [show with all ESTs]
    Unigene Representative Sequence: NM_005934
    2 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000252674(uc002mek.3) ENST00000585588

    miRNA
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    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat MLLT1
    8/39 QIAGEN miScript miRNA Assays for microRNAs that regulate MLLT1 (see all 39):
    hsa-miR-607 hsa-miR-449a hsa-miR-520g hsa-miR-3163 hsa-miR-34c-5p hsa-miR-571 hsa-miR-449b hsa-miR-561
    SwitchGear 3'UTR luciferase reporter plasmid: MLLT1 3' UTR sequence
    Inhib. RNA
    Products:             		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for MLLT1 (see all 7)
    OriGene shRNA RFP: MLLT1
    OriGene siRNA: MLLT1
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat MLLT1
    Clone
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    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for MLLT1
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    GenScript: all cDNA clones in your preferred vector: MLLT1 (NM_005934)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for MLLT1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MLLT1 
    Primer
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    Browse OriGene validated miRNA SYBR primer pairs
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat MLLT1
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat MLLT1
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat MLLT1

    Additional cDNA sequence: 

    AF373587.1 AL365410.1 AY040555.1 BC047008.1 BC063667.1 BC084564.1 D14539.1 L04285.1 

    5 DOTS entries:

    DT.203140  DT.91766924  DT.95232410  DT.95190965  DT.95190967 

    11 AceView cDNA sequences:

    BF804272 BF848582 L04285 D14539 NM_005934 BF748184 AY040555 H94599 
    BE177544 BF355840 BF355931 

    GeneLoc Exon Structure


    Expression
    for MLLT1 gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    MLLT1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: GGCTCCCAAG

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image

    MLLT1 expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
    Stem Cell Differentiation: 2 LifeMap Cells 
    NameCategory
    Syncytiotrophoblast-like cells (Generation of syncyt...)
    Posterior foregut-like cells (A scalable, suspensi...)
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization

    See MLLT1 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for MLLT1

    SOURCE GeneReport for Unigene cluster: Hs.10095
        SABiosciences Custom PCR Arrays for MLLT1
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    In Situ
    Assay Products:     
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MLLT1

    Orthologs
    for MLLT1 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of animals.

    Orthologs for MLLT1 gene from 5/18 species (see all 18)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    mouse
    (Mus musculus)    		 Mammalia Mllt11 , 5 myeloid/lymphoid or mixed-lineage leukemia (trithorax more1, 5 86.11(n)1
    88.48(a)1    		   17 (29.56 cM)5
    641441  NM_022328.21  NP_071723.11 
     568926125 
    chicken
    (Gallus gallus)    		 Aves MLLT11 myeloid/lymphoid or mixed-lineage leukemia (trithorax more 78.32(n)
    86.16(a)    		   420089  XM_418209.3  XP_418209.3 
    tropical clawed frog
    (Xenopus tropicalis)    		 Amphibia Str.62232 Transcribed sequence with moderate similarity to protein more 78.64(n)    142031938 
    zebrafish
    (Danio rerio)    		 Actinopterygii Dr.290842 Danio rerio cDNA clone IMAGE6793815, partial cds 77.98(n)    BC063028.1 
    fruit fly
    (Drosophila melanogaster)    		 Insecta ear1 , 3 transcription initiation from Pol II
    promoter more3
    ENL/AF9-related1    		 44(a)3
    44.82(n)1
    35.73(a)1    		   88F13
    444511  NM_143722.21  NP_651979.11 


    ENSEMBL Gene Tree for MLLT1 (if available)
    TreeFam Gene Tree for MLLT1 (if available) 

    Paralogs
    for MLLT1 gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for MLLT1 gene
    MLLT32  
    3 SIMAP similar genes for MLLT1 using alignment to 1 protein entry:     ENL_HUMAN:
    DKFZp686D09204    MLLT3    LTG9/MLLT3

    MLLT1 for paralogs           About GeneDecksing



    Genomic Variants
    for MLLT1 gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/1309 NCBI SNPs in MLLT1 are shown (see all 1309)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 19 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs1415448151,2
    		C,--6209900(+) CCTCC-/TTTCCG 1 -- int10--------
    rs2009239871,2
    		--6209903(+) TCCTT-/CCGTCCTT 1 -- int10--------
    rs1878540471,2
    		--6209957(+) CCATCA/GATCCA 1 -- int10--------
    rs72562821,2
    		C,F,H,--6210058(+) atccaC/Ttcacc 1 -- int16Minor allele frequency- T:0.04NS EA CSA WA 532
    rs1502760551,2
    		--6210183(+) TGAGCC/TGAATT 1 -- int10--------
    rs1484796321,2
    		C,--6210188(+) CGAAT-/TCTCTGC 1 -- int10--------
    rs104216031,2
    		C,F,--6210218(+) GCATCG/ATCTCC 1 -- int11Minor allele frequency- A:0.09WA 118
    rs1478601321,2
    		--6210375(+) GAACCA/CGGCAG 1 -- int10--------
    rs1415248731,2
    		--6210749(+) CCTATC/GGAAGT 1 -- ut310--------
    rs1470420811,2
    		--6210846(+) TGCCCA/GGCACG 1 -- ut310--------

    HapMap Linkage Disequilibrium report for MLLT1 (6210392 - 6279959 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
          Database of Genomic Variants (DGV) variations for MLLT1: --

    SABiosciences Cancer Mutation PCR Assays
    QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing MLLT1
    DNA2.0 Custom Variant and Variant Library Synthesis for MLLT1

    Disorders / Diseases
    for MLLT1 gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    MLLT1 for disorders           About GeneDecksing

    OMIM gene information: 159556    OMIM disorders: --

    UniProtKB/Swiss-Prot: ENL_HUMAN, Q03111
  • Note=A chromosomal aberration involving MLLT1 is associated with acute leukemias. Translocation
    • t(11;19)(q23;p13.3) with MLL/HRX. The result is a rogue activator protein

    10 diseases for MLLT1:    About MalaCards
    leukemia    acute lymphoblastic leukemia    lymphoblastic leukemia    acute myeloid leukemia
    myeloid leukemia    childhood leukemia    acute leukemia    neuritis
    leprosy    astrocytoma

    3 diseases from the University of Copenhagen DISEASES database for MLLT1:
    Leprosy     Leukemia     Neuritis

    2 Novoseek disease relationships for MLLT1 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    acute leukemia 58.7 2 16990786 (1)
    leukemia 51.3 8 12367585 (3), 11520560 (1), 18347158 (1)

    Human Genome Epidemiology (HuGE) Navigator: MLLT1 (1 document)

    Export disorders for MLLT1 gene to outside databases

    Publications
    for MLLT1 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for MLLT1 gene, integrated from 9 sources (see all 46):
    (articles sorted by number of sources associating them with MLLT1)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. Two distinct portions of LTG19/ENL at 19p13 are involved in t(11;19) leukemia. (PubMed id 8378076)1, 2, 9 Yamamoto K.... Ueda R. (1993)
    2. Involvement of a homolog of Drosophila trithorax by 11q23 chromosomal translocations in acute leukemias. (PubMed id 1423624)1, 2, 9 Tkachuk D.C.... Cleary M.L. (1992)
    3. HIV-1 Tat and host AFF4 recruit two transcription elo ngation factors into a bifunctional complex for coordinated activation of HIV-1 transcription. (PubMed id 20471948)1, 2 He N....Zhou Q. (2010)
    4. Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PubMed id 17081983)1, 2 Olsen J.V....Mann M. (2006)
    5. ENL, the gene fused with HRX in t(11;19) leukemias, encodes a nuclear protein with transcriptional activation potential in lymphoid and myeloid cells. (PubMed id 8080983)1, 2 Rubnitz J.E.... Cleary M.L. (1994)
    6. Simultaneous localization of MLL, AF4 and ENL genes in interphase nuclei by 3D-FISH: MLL translocation revisited. (PubMed id 16433901)1, 9 Gue M....Boudier T. (2006)
    7. A higher-order complex containing AF4 and ENL family proteins with P-TEFb facilitates oncogenic and physiologic MLL-dependent transc ription. (PubMed id 20153263)1, 9 Yokoyama A....Cleary M.L. (2010)
    8. Transcriptional and posttranscriptional regulation of HIV-1 gene expression. (PubMed id 22355797)1 Karn J. and Stoltzfus C.M. (2012)
    9. The ubiquitin ligase Siah1 controls ELL2 stability and formation of super elongation complexes to modulate gene transcription. (PubMed id 22483617)1 Liu M....Zhou Q. (2012)
    10. Global landscape of HIV-human protein complexes. (PubMed id 22190034)1 Jager S....Krogan N.J. (2012)

    External Searches for MLLT1 gene

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    Genome Databases showing MLLT1 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 4298 HGNC: 7134 AceView: MLLT1 Ensembl:ENSG00000130382 euGenes: HUgn4298
    ECgene: MLLT1 H-InvDB: MLLT1

    Other Databases showing MLLT1 gene

    (According to HUGE)
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    Specialized Databases showing MLLT1 gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for MLLT1 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for MLLT1 Genetics and Cytogenetics in Oncology and Haematology

    Intellectual Property
    for MLLT1 gene

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    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    		Patent Information for MLLT1 gene:
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