MLL5 Gene
protein-coding GIFtS: 53
GCID: GC07P104654
|
|
myeloid/lymphoid or mixed-lineage leukemia 5 (trithorax...
| |
Aliases
for MLL5 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Myeloid/Lymphoid Or Mixed-Lineage Leukemia 5 (Trithorax Homolog,Drosophila)1 2 | | Myeloid/Lymphoid Or Mixed-Lineage Leukemia Protein 52 3 | | KMT2E1 2 3 | | Histone-Lysine N-Methyltransferase MLL52 | | HDCMC04P1 2 | | EC 2.1.1.433 | | Lysine N-Methyltransferase 2E2 3 | | |
Export aliases for MLL5 gene to outside databasesPrevious GC identifers: GC07P103138 GC07P104201 GC07P104215 GC07P104248 GC07P104441 GC07P099014 |
Summaries
for MLL5 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for MLL5:
This gene is a member of the myeloid/lymphoid or mixed-lineage leukemia (MLL) family and encodes a protein with anN-terminal PHD zinc finger and a central SET domain. Overexpression of the protein inhibits cell cycle progression.Alternate transcriptional splice variants have been characterized. (provided by RefSeq, Jul 2008)
UniProtKB/Swiss-Prot: MLL5_HUMAN, Q8IZD2Function: Histone methyltransferase that specifically mono- and dimethylates 'Lys-4' of histone H3 (H3K4me1 andH3K4me2). H3 'Lys-4' methylation represents a specific tag for epigenetic transcriptional activation. Key regulator ofhematopoiesis involved in terminal myeloid differentiation and in the regulation of hematopoietic stem cell (HSCs)self-renewal by a mechanism that involves DNA methylation. Plays an essential role in retinoic-acid-inducedgranulopoiesis by acting as a coactivator of RAR-alpha (RARA) in target gene promoters. Also acts as an important cellcycle regulator, participating in cell cycle regulatory network machinery at multiple cell cycle stages. Required tosuppress inappropriate expression of S-phase-promoting genes and maintain expression of determination genes inquiescent cells. Overexpression inhibits cell cycle progression, while knockdown induces cell cycle arrest at both theG1 and G2/M phases
|
Genomic Views
for MLL5 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000007.13 NC_018918.1 NT_007933.15 NT_079596.2
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the MLL5 gene promoter:
E2F-4 E2F-3a E2F-5 Pax-5 E2F-2 NF-kappaB E2F-1 E2F HOXA5 NF-kappaB1
Other transcription factors
Search SABiosciences Chromatin IP Primers for MLL5
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat MLL5 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 7q22.1 Ensembl cytogenetic band: 7q22.3 HGNC cytogenetic band: 7q22.1MLL5 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 7 GeneLoc Exon Structure GeneLoc location for GC07P104654: view genomic region
(about GC identifiers)
Start:
|
104,654,626 bp from pter |
End:
|
104,754,808 bp from pter |
Size:
|
100,183 bases |
Orientation:
|
plus strand |
1 alternative location:
| Chr7+,CRA_TCAG 104,015,330-104,115,205 |
|
Proteins
for MLL5 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: MLL5_HUMAN, Q8IZD2 (See
protein sequence)Recommended Name: Histone-lysine N-methyltransferase MLL5 Size: 1858 amino acids; 204965 Da
Subunit: Component of the MLL5-L complex, at least composed of MLL5, STK38, PPP1CA, PPP1CB, PPP1CC, HCFC1, ACTB andOGT. Interacts with RARA
Subcellular location: Nucleus speckle. Note=Absent from the nucleolus
Sequence caution: Sequence=AAH01296.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential poly-Asequence starting in position 492; Sequence=AAH40004.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence.Potential poly-A sequence starting in position 227; Sequence=AAH53906.1; Type=Miscellaneous discrepancy;Note=Contaminating sequence. Potential poly-A sequence starting in position 227; Sequence=AAI42988.1;Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential poly-A sequence starting in position 492;
1 PDB 3D structure from  and Proteopedia  for MLL5:2LV9 (3D)
Secondary accessions: B6ZDE4 B6ZDM3 Q6P5Y2 Q6PKG4 Q6T316 Q86TI3 Q86W12 Q86WG0 Q86WL2 Q8IV78 Q8IWR5Q8NFF8 Q9NWE7Alternative splicing: 7 isoforms: Q8IZD2-1 Q8IZD2-2 Q8IZD2-3 Q8IZD2-4 Q8IZD2-5 Q8IZD2-6 Q8IZD2-7 (No experimental confirmation available)Explore the universe of human proteins at neXtProt for MLL5: NX_Q8IZD2
Post-translational modifications:
O-glycosylation at Thr-440 in the SET domain by OGT is essential for the histone methyltransferase and the coactivatoractivity toward RARA in granulopoiesis. The absence of Thr-440 glycosylation in assays done in vitro may explain whysome authors did not detected any histone methyltransferase activity for this protein1
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q8IZD2
MLL5 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins (2 alternative transcripts):
NP_061152.3 NP_891847.1
ENSEMBL proteins: ENSP00000312379 ENSP00000335398 ENSP00000419883 ENSP00000420415 ENSP00000417888 ENSP00000420206 ENSP00000417193 ENSP00000419525 ENSP00000417156 ENSP00000335599 ENSP00000257745 ENSP00000333986
Human Recombinant Protein Products for MLL5:
Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view): About this table
MLL5 for ontologies About GeneDecksing
MLL5 Antibody Products:
Assay Products for MLL5: |
Protein
Domains /
Families
for MLL5 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
MLL5 for domains About GeneDecksing
5/6 InterPro domains/families (see all 6):Graphical View of Domain Structure for InterPro Entry Q8IZD2ProtoNet protein and cluster: Q8IZD2 1 Blocks protein family: IPB001214 Nuclear protein SET
UniProtKB/Swiss-Prot: MLL5_HUMAN, Q8IZD2Similarity: Belongs to the histone-lysine methyltransferase family. TRX/MLL subfamilySimilarity: Contains 1 PHD-type zinc fingerSimilarity: Contains 1 SET domain |
Function
for MLL5 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
inGenious Targeting Laboratory,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase,
shRNA from
OriGene,
Sirion Biotech,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Sirion Biotech,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
Sirion Biotech,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Molecular Function:
UniProtKB/Swiss-Prot Summary: MLL5_HUMAN, Q8IZD2Function: Histone methyltransferase that specifically mono- and dimethylates 'Lys-4' of histone H3 (H3K4me1 andH3K4me2). H3 'Lys-4' methylation represents a specific tag for epigenetic transcriptional activation. Key regulator ofhematopoiesis involved in terminal myeloid differentiation and in the regulation of hematopoietic stem cell (HSCs)self-renewal by a mechanism that involves DNA methylation. Plays an essential role in retinoic-acid-inducedgranulopoiesis by acting as a coactivator of RAR-alpha (RARA) in target gene promoters. Also acts as an important cellcycle regulator, participating in cell cycle regulatory network machinery at multiple cell cycle stages. Required tosuppress inappropriate expression of S-phase-promoting genes and maintain expression of determination genes inquiescent cells. Overexpression inhibits cell cycle progression, while knockdown induces cell cycle arrest at both theG1 and G2/M phasesCatalytic activity: S-adenosyl-L-methionine + L-lysine-[histone] = S-adenosyl-L-homocysteine +N(6)-methyl-L-lysine-[histone] Enzyme Number (IUBMB): EC 2.1.1.431
Gene Ontology (GO): 5 molecular function terms (GO ID links to tree view): About this table
MLL5 for ontologies About GeneDecksing
Phenotypes:
2 GenomeRNAi human phenotypes for MLL5:
10 MGI mutant phenotypes (inferred from 4 alleles ) (MGI details for Mll5):
MLL5 for phenotypes About GeneDecksing
Animal Models:
Mouse knock-outs for MLL5: Mll5tm1Nik Mll5tm1.1Hjf Mll5tm1Apa
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for MLL5 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for MLL5 (see all 2)
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector (see all 2): MLL5 (NM_182931) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for MLL5 | |  | Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat MLL5 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MLL5 |
|
Pathways & Interactions
for MLL5 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Unified GeneCards pathways About this table
See pathways by source
| Super-pathway | contained gene-specific pathways |
|---|
| 1 | Lysine degradation | |
Pathway sources
See GeneCards unified pathways
Show all pathways
1 
Kegg Pathway (Kegg details for MLL5):
MLL5 for pathways About GeneDecksing
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for MLL5
STRING Interaction
Network Preview (showing 5 interactants - click image to see 14)
5/16 Interacting proteins for MLL5 (Q8IZD21, 3 ENSP000002577454) via UniProtKB, MINT, STRING, and/or I2D (see all 16)About this table
Gene Ontology (GO): 5/11 biological process terms (GO ID links to tree view) (see all 11): About this table
MLL5 for ontologies About GeneDecksing
|
Drugs & Compounds
for MLL5 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for MLL5
1 HMDB Compound for MLL5 About this table
Search CenterWatch for drugs/clinical trials and news about MLL5
|
Transcripts
for MLL5 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
Sirion Biotech,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for MLL5 gene (3 alternative transcripts): NM_018682.3 NM_182931.2 NM_032187.1 Unigene Cluster for MLL5: Myeloid/lymphoid or mixed-lineage leukemia 5 (trithorax homolog, Drosophila) Hs.592262 [show with all ESTs]Unigene Representative Sequence: AY14703717 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000311117(uc003vcm.3 uc010ljc.3) ENST00000334884(uc010lje.1 uc010ljg.3)
ENST00000478990 ENST00000480368 ENST00000495267 ENST00000476671(uc003vcl.3 uc003vco.1 uc010ljd.1)
ENST00000474203 ENST00000482560 ENST00000485619 ENST00000468607 ENST00000496191
ENST00000479838 ENST00000478079 ENST00000473063 ENST00000334877(uc010ljh.1)
ENST00000257745(uc010ljf.1) ENST00000334914(uc010lja.1 uc010ljb.1)
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for MLL5 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for MLL5 (see all 2)
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector (see all 2): MLL5 (NM_182931) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for MLL5 | | | Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat MLL5 |
Additional cDNA sequence: AF067804.1 AF519459.1 AK000940.1 AY113691.1 AY147037.1 AY157990.1 AY195568.1 AY195569.1 AY211524.1 AY211525.1 AY222296.1 AY234382.1 AY438698.1 AY438699.1 BC001296.2 BC009061.1 BC016382.1 BC024658.1 BC040004.1 BC053906.1 BC062583.1 BC142987.1 24/40 DOTS entries (see all 40): DT.432386 DT.100826379 DT.100826386 DT.438802 DT.91744219 DT.100677445 DT.92431870 DT.100826383 DT.92049253 DT.101964660 DT.101983981 DT.75107219 DT.40246346 DT.100014365 DT.100826378 DT.100826380 DT.40107704 DT.95189368 DT.100029257 DT.100826381 DT.100826387 DT.111791 DT.121104592 DT.121104639 24/332 AceView cDNA sequences (see all 332): AY195568 AY157990 AI889066 BM828190 AU118478 BM720064 CD678360 BE044400 BI038002 BQ669579 AI522222 AA284354 AI359982 AA598873 N51350 AI204939 CB163402 H88527 CD671479 AA972166 Z39065 AY195569 AI362678 BF057819
GeneLoc Exon Structure
5/14 Alternative Splicing Database (ASD) splice patterns (SP) for MLL5 (see all 14) About this scheme
| ExUns: | 1a | · | 1b | · | 1c | · | 1d | · | 1e | · | 1f | · | 1g | ^ | 2 | ^ | 3 | ^ | 4 | ^ | 5a | · | 5b | · | 5c | ^ | 6a | · | 6b | · | 6c | ^ | 7a | · | 7b | · | 7c | ^ | 8 | ^ | 9a | · | 9b | ^ | 10a | · | 10b | ^ | 11 | ^ | 12 | ^ |
|---|
|
| SP1: | | | | | | | | | | | | | | | | | - | | - | | | | | | - | | | | | | | | | | | | - | | | | | | | | | | | | | | | | |
| SP2: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP3: | | | | | | | | | | | | | | | - | | - | | - | | | | | | - | | | | | | | | | | | | - | | | | | | | | | | | | | | | | |
| SP4: | | | | | | | | | | | | | - | | - | | - | | - | | - | | | | - | | | | | | | | | | | | - | | | | | | | | | | | | | | | | |
| SP5: | | | | | | | | | | | - | | - | | - | | - | | - | | | | | | - | | | | | | | | | | | | - | | | | | | | | | | | | | | | |
| ExUns: | 13 | ^ | 14 | ^ | 15 | ^ | 16 | ^ | 17 | ^ | 18 | ^ | 19a | · | 19b | · | 19c | ^ | 20 | ^ | 21a | · | 21b | ^ | 22 | ^ | 23 | ^ | 24 | ^ | 25 | ^ | 26 | ^ | 27 | ^ | 28 | ^ | 29 |
|---|
|
| SP1: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP2: | | | | | | | | | | | | | | | | | | | | | | | - | | - | | | | | | | | | | | | | | | | |
| SP3: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP4: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP5: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
ECgene alternative splicing isoforms for MLL5
|
Expression
for MLL5 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| MLL5 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: TTAATAAATC
About this image
See MLL5 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for MLL5
SOURCE GeneReport for Unigene cluster: Hs.592262
UniProtKB/Swiss-Prot: MLL5_HUMAN, Q8IZD2Tissue specificity: Widely expressed in both adult and fetal tissues. Highest levels of expression observed in fetalthymus and kidney and in adult hematopoietic tissues, jejunum and cerebellum
SABiosciences Expression via Pathway-Focused PCR Arrays including MLL5: | Epigenetic Chromatin Modification Enzymes in human mouse rat | | Polycomb & Trithorax Complexes in human mouse rat |
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for MLL5
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse / rat MLL5 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat MLL5 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat MLL5 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MLL5 |
Orthologs
for MLL5 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of animals.
Orthologs for MLL5 gene from 6/18 species (see all 18) About this table
ENSEMBL Gene Tree for MLL5 (if available)
TreeFam Gene Tree for MLL5 (if available) |
Paralogs
for MLL5 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for MLL5 gene
- SETD52
18/20 SIMAP similar genes for MLL5 using alignment to 10 protein entries: MLL5_HUMAN (see all proteins)
(see all similar genes):NEK4 UTY SLMO1 UBE2V2 COQ5 KIAA0101
GNB2L1 CLTA AAMDC CCDC122 GEMIN6 ATF1
NCKAP1L ADCK1 HC6 DKFZp686A20205 ASH1L DYNC2LI1
MLL5 for paralogs About GeneDecksing
|
Genomic Variants
for MLL5 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 7 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for MLL5 (104654626 - 104754808 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 2 variations for MLL5
1 CNV: 8577
1 Indel: 59372
Human Gene Mutation Database (HGMD): MLL5
| SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing MLL5 |
|
Disorders
/ Diseases
for MLL5 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
MLL5 for disorders About GeneDecksing
OMIM gene information: 608444
OMIM disorders: --
9  diseases for MLL5: About MalaCardsleukemia acute myeloid leukemia myeloid leukemia myeloid malignancy
myelodysplastic syndrome hematopoiesis homocysteine cervical cancer
cervicitis
Export disorders for MLL5 gene to outside databases
|
Publications
for MLL5 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for MLL5 gene, integrated from 9 sources (see all 20):
(articles sorted by number of sources associating them with MLL5) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- MLL 5 protein forms intranuclear foci, and overexpression inhibits cell cycle progression. (PubMed id 14718661)1, 2, 9 Deng L.-W.... Strominger J.L. (2004)
- GlcNAcylation of a histone methyltransferase in retinoic-acid-induced granulopoiesis. (PubMed id 19377461)1, 2 Fujiki R.... Kato S. (2009)
- RNA interference against mixed lineage leukemia 5 resulted in cell cycle arrest. (PubMed id 18573682)1, 2 Cheng F.... Deng L.-W. (2008)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
- MLL5, a homolog of Drosophila trithorax located within a segment of chromosome band 7q22 implicated in myeloid leukemia. (PubMed id 12101424)1, 2 Emerling B.M.... Shannon K.M. (2002)
- Monosomy 7 and 7q--associated with myeloid malignancy. (PubMed id 9218106)1, 3 Johnson E. and Cotter F.E. (1997)
- Myelodysplastic syndromes: the pediatric point of view. (PubMed id 7672722)1, 3 Locatelli F....Severi F. (1995)
- Prognostic importance of histone methyltransferase ML L5 expression in acute myeloid leukemia. (PubMed id 21205756)1 Damm F....Heuser M. (2011)
- A novel MLL5 isoform that is essential to activate E6 and E7 transcription in HPV16/18-associated cervical cancers. (PubMed id 21908553)1 Yew C.W....Deng L.W. (2011)
- Camptothecin-induced downregulation of MLL5 contribut es to the activation of tumor suppressor p53. (PubMed id 21423215)1 Cheng F....Deng L.W. (2011)
|
External Searches for MLL5 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing MLL5 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing MLL5 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing MLL5 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
|
About This Section
| Patent Information for MLL5 gene:
Search GeneIP for patents involving MLL5
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for MLL5 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, LifeMap BioReagents, and Sirion Biotech, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory)
About This Section
|
 | |
 | |
 |
| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for MLL5 | | | Browse OriGene 29mer shRNA kits in GFP-retroviral vector | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for MLL5 | | | Browse OriGene Protein Over-expression Lysates | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for MLL5 | | OriGene 3'-UTR Clone for MLL5 | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for MLL5 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for MLL5 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for MLL5 | | OriGene Custom Protein Services for MLL5 | | | OriGene Custom Immunoassay Development | | |
| |
 |
 |
| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat MLL5 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing MLL5 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat MLL5 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat MLL5 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat MLL5 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat MLL5 |
| |
 |  |  |  | |
| | | | Search Tocris compounds for MLL5 |
| |  |  |  |  | | | | |
 |
 |
 |
 | | | MLL5 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MLL5 |
|  |  |  |  | | | | Search ThermoFisher Antibodies for MLL5 |
| | | Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat MLL5 |
| |  | |
|
|
|
