MLL2 Gene
protein-coding GIFtS: 60
GCID: GC12M049412
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|
myeloid/lymphoid or mixed-lineage leukemia 2(Previous name: trinucleotide repeat containing 21 )
(Previous symbol: TNRC21)
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Aliases
for MLL2 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Myeloid/Lymphoid Or Mixed-Lineage Leukemia 21 2 | | EC 2.1.1.433 8 | | ALR1 2 3 5 | | AAD102 | | KMT2D1 2 3 | | KABUK12 | | MLL41 2 3 | | KMS2 | | CAGL1141 2 | | Histone-Lysine N-Methyltransferase MLL22 | | TNRC211 2 | | Kabuki Make-Up Syndrome2 | | Trinucleotide Repeat Containing 211 2 | | Kabuki Mental Retardation Syndrome2 | | Lysine N-Methyltransferase 2D2 3 | | Myeloid/Lymphoid Or Mixed-Lineage Leukemia Protein 23 | | ALL1-Related Protein2 3 | | |
Export aliases for MLL2 gene to outside databasesPrevious GC identifers: GC12P049365 GC12M049129 GC12M047701 GC12M047699 GC12M046444 |
Summaries
for MLL2 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for MLL2:
The protein encoded by this gene is a histone methyltransferase that methylates the Lys-4 position of histone H3. Theencoded protein is part of a large protein complex called ASCOM, which has been shown to be a transcriptionalregulator of the beta-globin and estrogen receptor genes. Mutations in this gene have been shown to be a cause ofKabuki syndrome. (provided by RefSeq, Oct 2010)
UniProtKB/Swiss-Prot: MLL2_HUMAN, O14686Function: Histone methyltransferase. Methylates 'Lys-4' of histone H3 (H3K4me). H3K4me represents a specific tag forepigenetic transcriptional activation. Acts as a coactivator for estrogen receptor by being recruited by ESR1, therebyactivating transcription
Gene Wiki entry for MLL2
|
Genomic Views
for MLL2 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000012.11 NC_018923.1 NT_029419.12
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the MLL2 gene promoter:
Pax-5 Pax-6 MyoD XBP-1 Nkx2-5 GATA-1 MZF-1 PPAR-gamma1 PPAR-gamma2 MRF-2
Other transcription factors
Search SABiosciences Chromatin IP Primers for MLL2
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat MLL2 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 12q13.12 Ensembl cytogenetic band: 12q13.12 HGNC cytogenetic band: 12q13.12MLL2 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 12 GeneLoc Exon Structure GeneLoc location for GC12M049412: view genomic region
(about GC identifiers)
Start:
|
49,412,758 bp from pter |
End:
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49,453,557 bp from pter |
Size:
|
40,800 bases |
Orientation:
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minus strand |
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Proteins
for MLL2 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: MLL2_HUMAN, O14686 (See
protein sequence)Recommended Name: Histone-lysine N-methyltransferase MLL2 Size: 5537 amino acids; 593389 Da
Subunit: Component of the MLL2/3 complex (also named ASCOM complex), at least composed of MLL2/ALR or MLL3, ASH2L,RBBP5, WDR5, NCOA6, DPY30, KDM6A, PAXIP1/PTIP, PAGR1 and alpha- and beta-tubulin. Interacts with ESR1; interaction isdirect
Subcellular location: Nucleus (Probable)
Miscellaneous: This gene mapped to a chromosomal region involved in duplications and translocations associated withcancer
Caution: Another protein MLL4/WBP7, located on chromosome 19, was first named MLL2 (see AC Q9UMN6). Thus, MLL4 is oftenreferred to as MLL2 and vice versa in the literature
2 PDB 3D structures from  and Proteopedia  for MLL2:3UVK (3D)
4ERQ (3D)
Secondary accessions: O14687Alternative splicing: 2 isoforms: O14686-1 O14686-3 Explore the universe of human proteins at neXtProt for MLL2: NX_O14686
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_O14686
4/6 DME Specific Peptides for MLL2 (O14686) (see all 6)
MLL2 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_003473.3
ENSEMBL proteins: ENSP00000301067 ENSP00000435714 ENSP00000449455
Human Recombinant Protein Products:
Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view): About this table
MLL2 for ontologies About GeneDecksing
MLL2 Antibody Products:
Assay Products for MLL2: |
Protein
Domains /
Families
for MLL2 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
MLL2 for domains About GeneDecksing
5/10 InterPro domains/families (see all 10):Graphical View of Domain Structure for InterPro Entry O14686ProtoNet protein and cluster: O14686 3 Blocks protein families: IPB001214 Nuclear protein SET IPB001841 Zn-finger IPB003616 SET-related region
UniProtKB/Swiss-Prot: MLL2_HUMAN, O14686Domain: LXXLL motifs 5 and 6 are essential for the association with ESR1 nuclear receptorSimilarity: Belongs to the histone-lysine methyltransferase family. TRX/MLL subfamilySimilarity: Contains 1 FYR C-terminal domainSimilarity: Contains 1 FYR N-terminal domainSimilarity: Contains 5 PHD-type zinc fingersSimilarity: Contains 1 post-SET domainSimilarity: Contains 4 RING-type zinc fingersSimilarity: Contains 1 SET domain |
Function
for MLL2 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: MLL2_HUMAN, O14686Function: Histone methyltransferase. Methylates 'Lys-4' of histone H3 (H3K4me). H3K4me represents a specific tag forepigenetic transcriptional activation. Acts as a coactivator for estrogen receptor by being recruited by ESR1, therebyactivating transcriptionCatalytic activity: S-adenosyl-L-methionine + L-lysine-[histone] = S-adenosyl-L-homocysteine +N(6)-methyl-L-lysine-[histone] Genatlas biochemistry entry for MLL2:mixed (myeloid/lymphoid) lineage leukemia 2,paralogous gene of MLL chromosome 11
Enzyme Number (IUBMB): EC 2.1.1.431 2
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for MLL2
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for MLL2 (see all 2)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: MLL2 (NM_003482) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for MLL2 | |  | Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat MLL2 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MLL2 |
Gene Ontology (GO): 5/6 molecular function terms (GO ID links to tree view) (see all 6): About this table
MLL2 for ontologies About GeneDecksing
|
Pathways & Interactions
for MLL2 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Unified GeneCards pathways About this table
See pathways by source
| Super-pathway | contained gene-specific pathways |
|---|
| 1 | Lysine degradation | |
Pathway sources
See GeneCards unified pathways
Show all pathways
1 
Kegg Pathway (Kegg details for MLL2):
MLL2 for pathways About GeneDecksing
Interactions:
SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for MLL2
STRING Interaction
Network Preview (showing 5 interactants - click image to see 25)
5/590 Interacting proteins for MLL2 (O146861, 2, 3 ENSP000003010674) via UniProtKB, MINT, STRING, and/or I2D (see all 590)About this table
Gene Ontology (GO): 5/11 biological process terms (GO ID links to tree view) (see all 11): About this table
MLL2 for ontologies About GeneDecksing
|
Drugs & Compounds
for MLL2 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for MLL2
2 HMDB Compounds for MLL2 About this table
Search CenterWatch for drugs/clinical trials and news about MLL2
|
Transcripts
for MLL2 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for MLL2 gene: NM_003482.3 Unigene Cluster for MLL2: Myeloid/lymphoid or mixed-lineage leukemia 2 Hs.731384 [show with all ESTs]Unigene Representative Sequence: NM_0034827 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000301067(uc001rta.4) ENST00000526209 ENST00000552391 ENST00000549743
ENST00000549799 ENST00000550356 ENST00000547610
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for MLL2
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for MLL2 (see all 2)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: MLL2 (NM_003482) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for MLL2 | | | Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat MLL2 |
Additional cDNA sequence: AB209494.1 AF010403.1 AF010404.1 AL359940.1 BC039197.2 BC040663.2 CR749712.1 U80756.1 X85325.1 Y08267.1 20 DOTS entries: DT.102836886 DT.100749691 DT.97860248 DT.95314560 DT.411558 DT.121192255 DT.75151830 DT.91659551 DT.97786194 DT.99978924 DT.100059300 DT.92009427 DT.92050840 DT.92442800 DT.95314601 DT.100841362 DT.121192248 DT.92442804 DT.95140329 DT.95243329 9 AceView cDNA sequences: BC039197 AF010404 BC040663 AF010403 AL359940 NM_003482 CR749712 Y08267 X85325
GeneLoc Exon Structure
5/15 Alternative Splicing Database (ASD) splice patterns (SP) for MLL2 (see all 15) About this scheme
| ExUns: | 1 | ^ | 2 | ^ | 3a | · | 3b | ^ | 4a | · | 4b | ^ | 5 | ^ | 6 | ^ | 7 | ^ | 8 | ^ | 9 | ^ | 10 | ^ | 11 | ^ | 12 | ^ | 13a | · | 13b | · | 13c | ^ | 14a | · | 14b | ^ | 15 | ^ | 16 | ^ | 17 | ^ | 18 | ^ | 19 | ^ | 20 | ^ | 21 | ^ |
|---|
|
| SP1: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP2: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP3: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP4: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP5: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| ExUns: | 22 | ^ | 23 | ^ | 24 | ^ | 25 | ^ | 26a | · | 26b | ^ | 27 | ^ | 28 | ^ | 29 | ^ | 30 | ^ | 31 | ^ | 32 | ^ | 33 | ^ | 34 | ^ | 35 | ^ | 36 | ^ | 37a | · | 37b | ^ | 38 | ^ | 39 | ^ | 40 | ^ | 41 | ^ | 42a | · | 42b |
|---|
|
| SP1: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | - | | | | | | | | | | | | |
| SP2: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP3: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP4: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP5: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
ECgene alternative splicing isoforms for MLL2
|
Expression
for MLL2 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| MLL2 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: TTTTGTATCA
About this image
See MLL2 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for MLL2
SOURCE GeneReport for Unigene cluster: Hs.731384
UniProtKB/Swiss-Prot: MLL2_HUMAN, O14686Tissue specificity: Expressed in most adult tissues, including a variety of hematoipoietic cells, with the exception ofthe liver
SABiosciences Expression via Pathway-Focused PCR Array including MLL2: | Polycomb & Trithorax Complexes in human mouse rat |
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for MLL2
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat MLL2 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat MLL2 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat MLL2 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MLL2 |
Orthologs
for MLL2 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of eukaryotes.
Orthologs for MLL2 gene from 7/23 species (see all 23) About this table
ENSEMBL Gene Tree for MLL2 (if available)
TreeFam Gene Tree for MLL2 (if available) |
Paralogs
for MLL2 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for MLL2 gene
- MLL42 MLL2 SETD1B2 MLL32 SETD1A2
5 SIMAP similar genes for MLL2 using alignment to 4 protein entries: MLL2_HUMAN (see all proteins):DKFZp686C08112 MLL3 MLL4 MLL FP13812
MLL2 for paralogs About GeneDecksing
|
Genomic Variants
for MLL2 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 12 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for MLL2 (49412758 - 49453557 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 1 variation for MLL2
1 CNV: 4777
Human Gene Mutation Database (HGMD): MLL2
| SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing MLL2 |
|
Disorders
/ Diseases
for MLL2 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
MLL2 for disorders About GeneDecksing
OMIM gene information: 602113
OMIM disorders: 147920
UniProtKB/Swiss-Prot: MLL2_HUMAN, O14686
Defects in MLL2 are the cause of Kabuki syndrome type 1 (KABUK1) [MIM:147920]. A congenital mental retardationsyndrome with additional features, including postnatal dwarfism, a peculiar facies characterized by long palpebralfissures with eversion of the lateral third of the lower eyelids, a broad and depressed nasal tip, large prominentearlobes, a cleft or high-arched palate, scoliosis, short fifth finger, persistence of fingerpads, radiographicabnormalities of the vertebrae, hands, and hip joints, and recurrent otitis media in infancy
16  diseases for MLL2: About MalaCardskabuki syndrome mental retardation syndrome corneal staphyloma otitis media
leukemia weaver syndrome wermer syndrome spinocerebellar ataxia
fanconi's anemia dwarfism scoliosis acute leukemia
anemia ataxia homocysteine breast cancer
2 diseases from the University of Copenhagen DISEASES database for MLL2:Corneal staphyloma Weaver syndrome Export disorders for MLL2 gene to outside databases
|
Publications
for MLL2 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for MLL2 gene, integrated from 9 sources (see all 60):
(articles sorted by number of sources associating them with MLL2) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Structure and expression pattern of human ALR, a novel gene with strong homology to ALL-1 involved in acute leukemia and to Drosophila trithorax. (PubMed id 9247308)1, 2, 3, 9 Prasad R....Canaani E. (1997)
- MLL2 mutation spectrum in 45 patients with Kabuki syn drome. (PubMed id 21280141)1, 2 Paulussen A.D....Schrander-Stumpel C.T. (2011)
- Exome sequencing identifies MLL2 mutations as a cause of Kabuki syndrome. (PubMed id 20711175)1, 2 Ng S.B....Shendure J. (2010)
- PTIP Associates with MLL3- and MLL4-containing Histone H3 Lysine 4 Methyltransferase Complex. (PubMed id 17500065)1, 2 Cho Y.W.... Ge K. (2007)
- Demethylation of H3K27 regulates polycomb recruitment and H2A ubiquitination. (PubMed id 17761849)1, 2 Lee M.G.... Shiekhattar R. (2007)
- Identification of the MLL2 complex as a coactivator for estrogen receptor alpha. (PubMed id 16603732)1, 2 Mo R.... Zhu Y.-J. (2006)
- Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PubMed id 17081983)1, 2 Olsen J.V....Mann M. (2006)
- Activating signal cointegrator 2 belongs to a novel steady-state complex that contains a subset of trithorax group proteins. (PubMed id 12482968)1, 2 Goo Y.-H....Lee J.W. (2003)
- How genetically heterogeneous is Kabuki syndrome?: MLL 2 testing in 116 patients, review and analyses of mutation and phenotypic spectr um. (PubMed id 22126750)1 Banka S....Donnai D. (2012)
- A census of human soluble protein complexes. (PubMed id 22939629)1 Havugimana P.C....Emili A. (2012)
|
External Searches for MLL2 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing MLL2 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing MLL2 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing MLL2 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
|
About This Section
| Patent Information for MLL2 gene:
Search GeneIP for patents involving MLL2
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for MLL2 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
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| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for MLL2 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for MLL2 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for MLL2 | | | Browse OriGene Protein Over-expression Lysates | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for MLL2 | | OriGene 3'-UTR Clone for MLL2 | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for MLL2 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for MLL2 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for MLL2 | | OriGene Custom Protein Services for MLL2 | | | OriGene Custom Immunoassay Development | | |
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat MLL2 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing MLL2 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat MLL2 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat MLL2 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat MLL2 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat MLL2 |
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| | | | Search Tocris compounds for MLL2 |
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 | | | MLL2 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MLL2 |
|  |  |  | | | | Search ThermoFisher Antibodies for MLL2 |
| | | Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat MLL2 |
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