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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

MLKL Gene

protein-coding GIFtS: 53
GCID: GC16M074705

mixed lineage kinase domain-like

Explore 1 disease affiliated with
MLKL via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Mixed Lineage Kinase Domain-Like¹ ²
FLJ34389¹
Mixed Lineage Kinase Domain-Like Protein²

External Ids:	HGNC: 26617¹	Entrez Gene: 197259²	Ensembl: ENSG00000168404⁷	UniProtKB: Q8NB16³

Export aliases for MLKL gene to outside databases

Previous GC identifers: GC16M073264 GC16M060455

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

UniProtKB/Swiss-Prot: MLKL_HUMAN, Q8NB16

Function: Required for the execution of programmed necrosis

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000016.9 NC_018927.1 NT_010498.15

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the MLKL gene promoter:
TBP AML1a POU6F1 (c2) E4BP4 C/EBPalpha Evi-1 CREB NRF-2 deltaCREB En-1
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: MLKL promoter sequence

Search SABiosciences Chromatin IP Primers for MLKL

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat MLKL

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 16q23.1 Ensembl cytogenetic band: 16q23.1 HGNC cytogenetic band: 16q22.3

MLKL Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
MLKL gene location

GeneLoc information about chromosome 16 GeneLoc Exon Structure

GeneLoc location for GC16M074705: view genomic region (about GC identifiers)

Start:	74,705,753 bp from pter	End:	74,734,858 bp from pter
Size:	29,106 bases	Orientation:	minus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: MLKL_HUMAN, Q8NB16 (See protein sequence)

Recommended Name: Mixed lineage kinase domain-like protein

Size: 471 amino acids; 54479 Da

Subunit: Upon TNF-induced necrosis, forms in complex with PGAM5, RIPK1 and RIPK3. Within this complex, may play a role

in the proper targeting of RIPK1/RIPK3 to its downstream effector PGAM5

Secondary accessions: A6NCE4 Q8N6V0

Alternative splicing: 2 isoforms: Q8NB16-1 Q8NB16-2 (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for MLKL: NX_Q8NB16

Post-translational modifications:

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_Q8NB16

MLKL Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins (2 alternative transcripts):

NP_001135969.1 NP_689862.1

ENSEMBL proteins:

ENSP00000303118 ENSP00000308351 ENSP00000459935 ENSP00000461110 ENSP00000459920

ENSP00000461666

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(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

MLKL for domains About GeneDecksing

3 InterPro domains/families:

IPR011009 Kinase-like_dom

IPR000719 Prot_kinase_cat_dom

IPR001245 Ser-Thr/Tyr_kinase_cat_dom

Graphical View of Domain Structure for InterPro Entry Q8NB16

ProtoNet protein and cluster: Q8NB16

UniProtKB/Swiss-Prot: MLKL_HUMAN, Q8NB16

Domain: The protein kinase domain is predicted to be catalytically inactive

Similarity: Belongs to the protein kinase superfamily

Similarity: Contains 1 protein kinase domain

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Function Summary:

UniProtKB/Swiss-Prot: MLKL_HUMAN, Q8NB16

Function: Required for the execution of programmed necrosis

miRNA Products:		OriGene 3'-UTR Clone (see all 2): MLKL Browse MicroRNA Expression Plasmids
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In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MLKL

Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0004672	protein kinase activity	IEA	--
GO:0005515	protein binding	IPI	--
GO:0005524	ATP binding	IEA	--

MLKL for ontologies About GeneDecksing

6 GenomeRNAi human phenotypes for MLKL:

Decreased focal adhesion (FA)	Decreased influenza A virus in	Downregulation of NF-kappaB pa	Downregulation of NF-kappaB pa
Increased colony dispersion (i	Synthetic lethal with Ras

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Unified GeneCards pathways About this table

See pathways by source

Super-pathway

contained gene-specific pathways

Wnt Signaling Pathway

DNA damage response (only ATM dependent)

0.35

1 BioSystems Pathway for MLKL

DNA damage response (only ATM dependent)

Interactions:

Search SABiosciences Gene Network Central^TM Interacting Genes and Proteins Networks for MLKL

STRING Interaction Network Preview (showing 5 interactants - click image to see 9)

5/565 Interacting proteins for MLKL (Q8NB16^{1, 2, 3} ENSP00000308351⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 565)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
PBX2	P40425²^,³	MINT-62574 MINT-62748 MINT-62672 I2D: score=2
PITPNA	Q00169³, ENSP00000316809⁴	I2D: score=2 STRING: ENSP00000316809
RAD18	Q9NS91², ENSP00000264926⁴	MINT-7945693 STRING: ENSP00000264926
RIPK3	Q9Y572¹, ENSP00000216274⁴	EBI-1055040,EBI-358587 STRING: ENSP00000216274
SNW1	Q13573², ENSP00000261531⁴	MINT-7945693 STRING: ENSP00000261531

About this table

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for MLKL

2 HMDB Compounds for MLKL About this table

Compound	Synonyms	CAS #	PubMed Ids
ADP	adenosindiphosphorsaeure (see all 8)	58-64-0	--
Adenosine triphosphate	5'-(tetrahydrogen triphosphate) Adenosine (see all 24)	56-65-5	--

Search CenterWatch for drugs/clinical trials and news about MLKL

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for MLKL gene (2 alternative transcripts):

NM_001142497.1 NM_152649.2

Unigene Cluster for MLKL:

Mixed lineage kinase domain-like

Hs.119878 [show with all ESTs]

Unigene Representative Sequence: AK122998

8 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000306247 ENST00000575695 ENST00000570846 ENST00000308807(uc002fdb.2 uc002fdc.2)

ENST00000576529 ENST00000571303 ENST00000573267 ENST00000575686

miRNA Products:		OriGene 3'-UTR Clone (see all 2): MLKL Browse OriGene MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat MLKL
		4 QIAGEN miScript miRNA Assays for microRNAs that regulate MLKL:
		hsa-miR-3655 hsa-miR-194 hsa-miR-578 hsa-miR-103a-2*
		SwitchGear 3'UTR luciferase reporter plasmid: MLKL 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
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Additional cDNA sequence:

AK091708.1 AK093013.1 AK122998.1 AL833362.1 BC028141.1

7 DOTS entries:

DT.100649024 DT.409298 DT.100025407 DT.421346 DT.100649026 DT.101985719 DT.75157785

24/64 AceView cDNA sequences (see all 64):

BC028141 CR607857 CA487359 BP345323 CB069503 BQ575071 CA487239 AW963910

BQ709249 CR595250 AA706818 AL833362 AA582672 CB159407 BX352121 BX384496

AA307123 CD516215 BX436432 AA765938 AA381661 AA381405 BX106138 AK122998

GeneLoc Exon Structure

4 Alternative Splicing Database (ASD) splice patterns (SP) for MLKL About this scheme

ExUns:	1	^	2	^	3	^	4	^	5	^	6	^	7a	·	7b	^	8a	·	8b	^	9a	·	9b	^	10	^	11
SP1:													-		-								-
SP2:													-
SP3:					-		-		-		-		-		-		-		-
SP4:

ECgene alternative splicing isoforms for MLKL

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

MLKL expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: AATGAGGCCA

About this image

MLKL expression in embryonic tissues and stem cells

Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

1 LifeMap In Vivo Development Anatomical Compartment/Cell

Tissue

Anatomical Compartment

Cell

Category (developmental path)

Testis

Seminiferous Tubules

Spermatid

Germ Cells, Male Gametocytes

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

See MLKL Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for MLKL

SOURCE GeneReport for Unigene cluster: Hs.119878

SABiosciences Custom PCR Arrays for MLKL

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In Situ
Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MLKL

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of chordates.

Orthologs for MLKL gene from 3/8 species (see all 8) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
mouse (Mus musculus)	Mammalia	Mlkl^{1 , 5}	mixed lineage kinase domain-like^{1, 5}	76.01(n)¹ 63.8(a)¹		8 (57.98 cM)⁵ 74568¹ NM_029005.2¹ NP_083281.1¹ 111311797⁵
chicken (Gallus gallus)	Aves	LOC415686¹	mixed lineage kinase domain-like protein-like	54.06(n) 41.45(a)		415686 XM_003641903.1 XP_003641951.1
lizard (Anolis carolinensis)	Reptilia	MLKL⁶	--	40(a)	1 ↔ 1	GL343840.1(171460-179490)

ENSEMBL Gene Tree for MLKL (if available)
TreeFam Gene Tree for MLKL (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 16 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs186075101^1,2		--	74705277(+)	`CCTCCC/TGCCTG`	2	--	int¹		0	--	--	--	--
rs147217623^1,2		--	74705295(+)	`CAAAGC/TGCTGG`	2	--	int¹		0	--	--	--	--
rs140650134^1,2		--	74705296(+)	`AAAGCA/GCTGGG`	2	--	int¹		0	--	--	--	--
rs142796484^1,2		--	74705321(+)	`TCACCA/GTGCCC`	2	--	int¹		0	--	--	--	--
rs147411933^1,2		--	74705352(+)	`GAGATA/GCTGAC`	2	--	int¹		0	--	--	--	--
rs80147602^1,2	C,F,	--	74705424(+)	`GCTCTA/GGAAAT`	2	--	int¹		5		NA WA EA	362
rs190881491^1,2		--	74705458(+)	`AAAGTA/GTAGAC`	2	--	int¹		0	--	--	--	--
rs148526700^1,2		--	74705588(+)	`GAGAAC/TTCTGG`	2	--	int¹		0	--	--	--	--
rs142879114^1,2		--	74705726(+)	`TACTTC/GTGTTG`	2	--	int¹		0	--	--	--	--
rs183429081^1,2		--	74705735(+)	`TGTGTA/GAAAAA`	2	--	int¹		0	--	--	--	--

HapMap Linkage Disequilibrium report for MLKL (74705753 - 74734858 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for MLKL: --

SABiosciences Cancer Mutation PCR Assays

QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing MLKL

DNA2.0 Custom Variant and Variant Library Synthesis for MLKL

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

MLKL for disorders About GeneDecksing

1 disease for MLKL: About MalaCards

cholesterol

Human Genome Epidemiology (HuGE) Navigator: MLKL (1 document)

Export disorders for MLKL gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

PubMed articles for MLKL gene, integrated from 9 sources (see all 18):
(articles sorted by number of sources associating them with MLKL)

Utopia: connect your pdf to the dynamic
world of online information

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S....Malek J. (2004)
Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)^{1, 2} Ota T.... Sugano S. (2004)
The protein kinase complement of the human genome. (PubMed id 12471243)^{1, 2} Manning G.... Sudarsanam S. (2002)
Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)^{1, 3} Strausberg R.L....Marra M.A. (2002)
Mixed lineage kinase domain-like is a key receptor int eracting protein 3 downstream component of TNF-induced necrosis. (PubMed id 22421439)¹ Zhao J....Liu Z.G. (2012)
Mixed lineage kinase domain-like protein mediates necr osis signaling downstream of RIP3 kinase. (PubMed id 22265413)¹ Sun L....Wang X. (2012)
The mitochondrial phosphatase PGAM5 functions at the c onvergence point of multiple necrotic death pathways. (PubMed id 22265414)² Wang Z....Wang X. (2012)
Initial characterization of the human central proteome. (PubMed id 21269460)² Burkard T.R.... Colinge J. (2011)
Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis. (PubMed id 20068231)² Olsen J.V....Mann M. (2010)
Fine mapping and association studies of a high-densit y lipoprotein cholesterol linkage region on chromosome 16 in French-Canadian su bjects. (PubMed id 19844255)¹ Dastani Z....Genest J. (2010)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

Entrez Gene: 197259	HGNC: 26617	AceView: FLJ34389	Ensembl:ENSG00000168404	euGenes: HUgn197259
ECgene: MLKL	H-InvDB: MLKL

(According to HUGE)
About This Section

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
PharmGKB entry for MLKL	Pharmacogenomics, SNPs, Pathways

Intellectual Property for MLKL gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

About This Section

Patent Information for MLKL gene:
Search GeneIP for patents involving MLKL

GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search

(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section


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	OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for MLKL		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for MLKL
	Browse OriGene Protein Over-expression Lysates		Browse OriGene Fluorogenic Cell Assay Kits
	Browse OriGene siRNAs		OriGene 3'-UTR Clone for MLKL
	OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for MLKL		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for MLKL
	Browse OriGene GFP tagged cDNA clones in CMV expression vector		Browse OriGene MicroRNA Expression Plasmids
	Browse OriGene basic RS shRNAs		Browse OriGene validated miRNA SYBR primer pairs
	Browse OriGene full length recombinant human proteins expressed in human HEK293 cells		OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
	OriGene Custom Antibody Services for MLKL		OriGene Custom Protein Services for MLKL
	OriGene Custom Immunoassay Development

	QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat MLKL
	QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing MLKL
	QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat MLKL
	QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat MLKL
	QIAGEN QuantiFast Probe-based Assays in human, mouse, rat MLKL
	QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat MLKL

	GenScript Custom Purified and Recombinant Proteins Services for MLKL		GenScript cDNA clones with any tag delivered in your preferred vector for MLKL
	GenScript Custom Assay Services for MLKL		GenScript Custom Superior Antibodies Services for MLKL
	GenScript Custom overexpressing Cell Line Services for MLKL		CloneReady with Over 120,000 Genes
	Gene Synthesis: Any Gene in Any Vector		Vector-based siRNA and miRNA, Ready for Transfection
	Gene Mutant Library, Variants up to 10^11		Plasmid Preparation
	Custom Peptide Services

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	Regulatory tfbs in MLKL promoter
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Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

	Novus Tissue Slides
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	See all of Abcam's Antibodies, Kits and Proteins for MLKL
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Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MLKL

	SwitchGear 3'UTR luciferase reporter plasmids for MLKL
	SwitchGear Promoter luciferase reporter plasmids for MLKL

ThermoFisher Antibodies for MLKL

Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MLKL

GeneCards Homepage - Last full update: 19 Mar 2013 - Incrementals: 21 Mar 2013 , 15 Apr 2013 , 26 Apr 2013

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Category			VWF (GIFTS: 73) von Willebrand factor
GIFtS Group

The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

The GeneCards Human Gene Database

Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

Hot genes Disease genes MLKL gene at Home site.

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MLKL Gene

mixed lineage kinase domain-like

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MLKL Gene

mixed lineage kinase domain-like

Aliasesfor MLKL gene

Summariesfor MLKL gene

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Functionfor MLKL gene

Pathways & Interactionsfor MLKL gene

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for MLKL gene

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for MLKL gene

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