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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

MLKL Gene

protein-coding   GIFtS: 57
GCID: GC16M074705

Mixed Lineage Kinase Domain-Like

  Search for MLKL
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Mixed Lineage Kinase Domain-Like1 2
Mixed Lineage Kinase Domain-Like Protein2

External Ids:    HGNC: 266171   Entrez Gene: 1972592   Ensembl: ENSG000001684047   OMIM: 6151535   UniProtKB: Q8NB163   

Export aliases for MLKL gene to outside databases

Previous GC identifers: GC16M073264 GC16M060455


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for MLKL Gene: 
MLKL (mixed lineage kinase domain-like) is a protein-coding gene. Among its related super-pathways are Wnt Signaling Pathway. GO annotations related to this gene include protein kinase activity and ATP binding.

UniProtKB/Swiss-Prot: MLKL_HUMAN, Q8NB16
Function: Required for the execution of programmed necrosis




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000016.9  NT_010498.15  NC_018927.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the MLKL gene promoter:
         TBP   AML1a   POU6F1 (c2)   E4BP4   C/EBPalpha   Evi-1   CREB   NRF-2   deltaCREB   En-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidMLKL promoter sequence
   Search SABiosciences Chromatin IP Primers for MLKL

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat MLKL


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 16q23.1   Ensembl cytogenetic band:  16q23.1   HGNC cytogenetic band: 16q22.3

MLKL Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
MLKL gene location

GeneLoc information about chromosome 16         GeneLoc Exon Structure

GeneLoc location for GC16M074705:  view genomic region     (about GC identifiers)

Start:
74,705,753 bp from pter      End:
74,734,858 bp from pter
Size:
29,106 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: MLKL_HUMAN, Q8NB16 (See protein sequence)
Recommended Name: Mixed lineage kinase domain-like protein  
Size: 471 amino acids; 54479 Da
Subunit: Upon TNF-induced necrosis, forms in complex with PGAM5, RIPK1 and RIPK3. Within this complex, may play a
role in the proper targeting of RIPK1/RIPK3 to its downstream effector PGAM5
Secondary accessions: A6NCE4 Q8N6V0
Alternative splicing: 2 isoforms:  Q8NB16-1   Q8NB16-2   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for MLKL: NX_Q8NB16

Explore proteomics data for MLKL at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q8NB16

  • MLKL Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    MLKL Protein Expression
    REFSEQ proteins (2 alternative transcripts): 
    NP_001135969.1  NP_689862.1  

    ENSEMBL proteins: 
     ENSP00000303118   ENSP00000308351   ENSP00000459935   ENSP00000461110   ENSP00000459920  
     ENSP00000461666  

    Human Recombinant Protein Products for MLKL: 
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    Novus Biologicals MLKL Proteins
    Novus Biologicals MLKL Lysate
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for MLKL 


    MLKL Antibody Products: 
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    LSBio Antibodies in human, mouse, rat for MLKL 

    Assay Products for MLKL: 
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    Cloud-Clone Corp. ELISAs for MLKL 
    Cloud-Clone Corp. CLIAs for MLKL


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    IUPHAR Guide to PHARMACOLOGY protein family classification: mixed lineage kinase domain-like 
    TKL-unique family

    3 InterPro protein domains:
     IPR011009 Kinase-like_dom
     IPR000719 Prot_kinase_cat_dom
     IPR001245 Ser-Thr/Tyr_kinase_cat_dom

    Graphical View of Domain Structure for InterPro Entry Q8NB16

    ProtoNet protein and cluster: Q8NB16

    UniProtKB/Swiss-Prot: MLKL_HUMAN, Q8NB16
    Domain: The protein kinase domain is predicted to be catalytically inactive
    Similarity: Belongs to the protein kinase superfamily
    Similarity: Contains 1 protein kinase domain


    MLKL for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: MLKL_HUMAN, Q8NB16
    Function: Required for the execution of programmed necrosis

         Gene Ontology (GO): 5 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004672protein kinase activity IEA--
    GO:0004713protein tyrosine kinase activity ----
    GO:0005515protein binding IPI--
    GO:0005524ATP binding IEA--
    GO:0016772transferase activity, transferring phosphorus-containing groups ----
         
    MLKL for ontologies           About GeneDecksing


    Phenotypes:
         6 GenomeRNAi human phenotypes for MLKL:
     Decreased focal adhesion (FA)   Decreased influenza A virus in  Downregulation of NF-kappaB pa  Downregulation of NF-kappaB pa 
     Increased colony dispersion (i  Synthetic lethal with Ras 

    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for MLKL 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for MLKL

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for MLKL 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for MLKL 

    miRNA
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    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat MLKL
    4 QIAGEN miScript miRNA Assays for microRNAs that regulate MLKL:
    hsa-miR-3655 hsa-miR-194 hsa-miR-578 hsa-miR-103a-2*
    SwitchGear 3'UTR luciferase reporter plasmidMLKL 3' UTR sequence
    Inhib. RNA
    Products:
        
    Browse for Gene Knock-down Tools from EMD Millipore
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    Gene Editing
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    Browse Sino Biological Human cDNA Clones
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    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MLKL


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for MLKL About                                                                                                See pathways by source

    SuperPathContained pathways About
    1Wnt Signaling Pathway
    DNA damage response (only ATM dependent)0.32
    2TNF signaling pathway
    TNF signaling pathway

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 BioSystems Pathway for MLKL
        DNA damage response (only ATM dependent)


    1         Kegg Pathway  (Kegg details for MLKL):
        TNF signaling pathway


    MLKL for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for MLKL

    STRING Interaction Network Preview (showing 5 interactants - click image to see 9)

    5/598 Interacting proteins for MLKL (Q8NB161, 2, 3 ENSP000003083514) via UniProtKB, MINT, STRING, and/or I2D (see all 598)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ENSG00000237344P404252, 3, ENSP000003971774MINT-62574 MINT-62748 MINT-62672 I2D: score=2 STRING: ENSP00000397177
    ENSG00000206315P404252, 3MINT-62574 MINT-62748 MINT-62672 I2D: score=2 
    ENSG00000224952P404252, 3MINT-62574 MINT-62748 MINT-62672 I2D: score=2 
    ENSG00000225987P404252, 3MINT-62574 MINT-62748 MINT-62672 I2D: score=2 
    ENSG00000232005P404252, 3MINT-62574 MINT-62748 MINT-62672 I2D: score=2 
    About this table

    Gene Ontology (GO): 1 biological process term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006468protein phosphorylation ----

    MLKL for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for MLKL

    2 HMDB Compounds for MLKL    About this table
    CompoundSynonyms CAS #PubMed Ids
    ADPadenosindiphosphorsaeure (see all 8)58-64-0--
    Adenosine triphosphate5'-(tetrahydrogen triphosphate) Adenosine (see all 24)56-65-5--

    Search CenterWatch for drugs/clinical trials and news about MLKL

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for MLKL gene (2 alternative transcripts): 
    NM_001142497.1  NM_152649.2  

    Unigene Cluster for MLKL:

    Mixed lineage kinase domain-like
    Hs.119878  [show with all ESTs]
    Unigene Representative Sequence: AK122998
    8 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000306247 ENST00000575695 ENST00000570846 ENST00000308807(uc002fdb.2 uc002fdc.2)
    ENST00000576529 ENST00000571303 ENST00000573267 ENST00000575686
    miRNA
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    4 QIAGEN miScript miRNA Assays for microRNAs that regulate MLKL:
    hsa-miR-3655 hsa-miR-194 hsa-miR-578 hsa-miR-103a-2*
    SwitchGear 3'UTR luciferase reporter plasmidMLKL 3' UTR sequence
    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
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    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat MLKL
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    GenScript: all cDNA clones in your preferred vector (see all 2): MLKL (NM_152649)
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MLKL
    Sirion Biotech Customized lentivirus for stable overexpression of MLKL 
                         Customized lentivirus expression plasmids for stable overexpression of MLKL 
    Primer
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    OriGene qPCR primer pairs and template standards for MLKL
    OriGene qSTAR qPCR primer pairs in human, mouse for MLKL
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat MLKL
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat MLKL
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat MLKL

    Additional mRNA sequence: 

    AK091708.1 AK093013.1 AK122998.1 AL833362.1 BC028141.1 

    7 DOTS entries:

    DT.100649024  DT.409298  DT.100025407  DT.421346  DT.100649026  DT.101985719  DT.75157785 

    24/64 AceView cDNA sequences (see all 64):

    CR595250 CA487239 AA706818 BP345323 CR607857 BQ709249 AL833362 BC028141 
    BQ575071 CA487359 CB069503 AA582672 CB159407 AW963910 BX352121 CD516215 
    BX384496 CD369377 AK093013 AA381661 BG751761 AA307123 AI351962 BX436432 

    GeneLoc Exon Structure

    4 Alternative Splicing Database (ASD) splice patterns (SP) for MLKL    About this scheme

    ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7a · 7b ^ 8a · 8b ^ 9a · 9b ^ 10 ^ 11
    SP1:                                      -     -                       -               
    SP2:                                      -                                             
    SP3:              -     -     -     -     -     -     -     -                           
    SP4:                                                                                    


    ECgene alternative splicing isoforms for MLKL

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    MLKL expression in normal human tissues (normalized intensities)      MLKL embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: AATGAGGCCA
    MLKL Expression
    About this image


    MLKL expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/3 selected tissues (see all 3) fully expand
     
     Heart (Cardiovascular System)
             Mature Cardiac Fibroblasts Myocardium
     
     Epidermis (Integumentary System)
     
     Dermis (Integumentary System)

    See MLKL Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for MLKL

    SOURCE GeneReport for Unigene cluster: Hs.119878
        SABiosciences Custom PCR Arrays for MLKL
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MLKL

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of chordates.

    Orthologs for MLKL gene from 3/8 species (see all 8)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Mlkl1 , 5 mixed lineage kinase domain-like1, 5 76.01(n)1
    63.8(a)1
      8 (57.98 cM)5
    745681  NM_029005.21  NP_083281.11 
     1113117975 
    chicken
    (Gallus gallus)
    Aves LOC4156861 mixed lineage kinase domain-like protein-like 54.06(n)
    41.45(a)
      415686  XM_003641903.1  XP_003641951.1 
    lizard
    (Anolis carolinensis)
    Reptilia MLKL6
    mixed lineage kinase domain-like
    41(a)
    1 ↔ 1
    GL343840.1(169943-181785)


    ENSEMBL Gene Tree for MLKL (if available)
    TreeFam Gene Tree for MLKL (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for MLKL gene
    2 SIMAP similar genes for MLKL using alignment to 5 protein entries:     MLKL_HUMAN (see all proteins):
    DKFZp667E1714    TNNI3K

    MLKL for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/844 SNPs in MLKL are shown (see all 844)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 16 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0413574
    A gastric adenocarcinoma sample4--see VAR_0413572 F I mis40--------
    VAR_0413554
    A gastric adenocarcinoma sample4--see VAR_0413552 L P mis40--------
    rs1860751011,2
    --74705277(+) CCTCCC/TGCCTG 2 -- int10--------
    rs1472176231,2
    --74705295(+) CAAAGC/TGCTGG 2 -- int10--------
    rs1406501341,2
    C--74705296(+) AAAGCA/GCTGGG 2 -- int10--------
    rs1427964841,2
    --74705321(+) TCACCA/GTGCCC 2 -- int10--------
    rs1474119331,2
    --74705352(+) GAGATA/GCTGAC 2 -- int10--------
    rs801476021,2
    C,F--74705424(+) GCTCTA/GGAAAT 2 -- int15Minor allele frequency- G:0.08NA WA EA 362
    rs1908814911,2
    C--74705458(+) AAAGTA/GTAGAC 2 -- int10--------
    rs1485267001,2
    --74705588(+) GAGAAC/TTCTGG 2 -- int10--------

    HapMap Linkage Disequilibrium report for MLKL (74705753 - 74734858 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 3 variations for MLKL:    About this table     
    Variant IDTypeSubtypePubMed ID
    nsv906907CNV Loss21882294
    nsv906906CNV Gain21882294
    esv275138CNV Gain+Loss21479260

    SABiosciences Cancer Mutation PCR Assays
    SeqTarget long-range PCR primers for resequencing MLKL
    DNA2.0 Custom Variant and Variant Library Synthesis for MLKL

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    MLKL for disorders           About MalaCards
    OMIM gene information: 615153    OMIM disorders: --


    MLKL for disorders           About GeneDecksing

    Genetic Association Database (GAD): MLKL
    Human Genome Epidemiology (HuGE) Navigator: MLKL (1 document)

    Export disorders for MLKL gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for MLKL gene, integrated from 9 sources (see all 22):
    (articles sorted by number of sources associating them with MLKL)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Fine mapping and association studies of a high-densit y lipoprotein cholesterol linkage region on chromosome 16 in French-Canadian su bjects. (PubMed id 19844255)1, 4 Dastani Z....Genest J. (2010)
    2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    4. The protein kinase complement of the human genome. (PubMed id 12471243)1, 2 Manning G.... Sudarsanam S. (2002)
    5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1, 3 Strausberg R.L....Marra M.A. (2002)
    6. Diverse sequence determinants control human and mouse receptor interacting protein 3 (RIP3) and mixed lineage kinase domain-like (MLKL ) interaction in necroptotic signaling. (PubMed id 23612963)1 Chen W....Han J. (2013)
    7. Mixed lineage kinase domain-like is a key receptor int eracting protein 3 downstream component of TNF-induced necrosis. (PubMed id 22421439)1 Zhao J....Liu Z.G. (2012)
    8. Mixed lineage kinase domain-like protein mediates necr osis signaling downstream of RIP3 kinase. (PubMed id 22265413)1 Sun L....Wang X. (2012)
    9. The mitochondrial phosphatase PGAM5 functions at the c onvergence point of multiple necrotic death pathways. (PubMed id 22265414)2 Wang Z....Wang X. (2012)
    10. Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (2011)

    (in PubMed, OMIM, and NCBI Bookshelf)
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 197259 HGNC: 26617 AceView: FLJ34389 Ensembl:ENSG00000168404 euGenes: HUgn197259
    ECgene: MLKL Kegg: 197259 H-InvDB: MLKL

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for MLKL Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for MLKL gene:
    Search GeneIP for patents involving MLKL

    GeneCards and IP:
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