Aliases for MLKL Gene
External Ids for MLKL Gene
Previous GeneCards Identifiers for MLKL Gene
GeneCards Summary for MLKL Gene
MLKL (Mixed Lineage Kinase Domain-Like) is a Protein Coding gene. Among its related pathways are TNF signaling pathway and Wnt Signaling Pathway (WikiPathways). GO annotations related to this gene include protein kinase activity.
UniProtKB/Swiss-Prot for MLKL Gene
Pseudokinase that plays a key role in TNF-induced necroptosis, a programmed cell death process. Activated following phosphorylation by RIPK3, leading to homotrimerization, localization to the plasma membrane and execution of programmed necrosis characterized by calcium influx and plasma membrane damage. Does not have protein kinase activity.