Free for academic non-profit institutions. Other users need a Commercial license

Aliases for MLIP Gene

Aliases for MLIP Gene

  • Muscular LMNA-Interacting Protein 2 3
  • C6orf142 3 4 6
  • Muscular-Enriched A-Type Laminin-Interacting Protein 3 4
  • Muscle-Enriched A-Type Lamin Interacting Protein 2 3
  • Chromosome 6 Open Reading Frame 142 2

External Ids for MLIP Gene

Previous HGNC Symbols for MLIP Gene

  • C6orf142

Previous GeneCards Identifiers for MLIP Gene

  • GC06P053796

Summaries for MLIP Gene

GeneCards Summary for MLIP Gene

MLIP (Muscular LMNA-Interacting Protein) is a Protein Coding gene.

Gene Wiki entry for MLIP Gene

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MLIP Gene

Genomics for MLIP Gene

Genomic Location for MLIP Gene

Start:
53,929,982 bp from pter
End:
54,266,323 bp from pter
Size:
336,342 bases
Orientation:
Plus strand

Genomic View for MLIP Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for MLIP Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MLIP Gene

No data available for Regulatory Elements for MLIP Gene

Proteins for MLIP Gene

  • Protein details for MLIP Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q5VWP3-MLIP_HUMAN
    Recommended name:
    Muscular LMNA-interacting protein
    Protein Accession:
    Q5VWP3
    Secondary Accessions:
    • B7Z2N0
    • D6RE05
    • Q96H08
    • Q96NF7

    Protein attributes for MLIP Gene

    Size:
    458 amino acids
    Molecular mass:
    50429 Da
    Quaternary structure:
    • Interacts with LMNA; may regulate MLIP localization to the nucleus envelope.
    SequenceCaution:
    • Sequence=CAI13927.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};

    Alternative splice isoforms for MLIP Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for MLIP Gene

Proteomics data for MLIP Gene at MOPED

Post-translational modifications for MLIP Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for MLIP Gene

Domains for MLIP Gene

Protein Domains for MLIP Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for MLIP Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with MLIP: view

No data available for Gene Families and UniProtKB/Swiss-Prot for MLIP Gene

Function for MLIP Gene

Gene Ontology (GO) - Molecular Function for MLIP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001191 RNA polymerase II transcription factor binding transcription factor activity involved in negative regulation of transcription IEA --
genes like me logo Genes that share ontologies with MLIP: view

Animal Model Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for MLIP Gene

Localization for MLIP Gene

Subcellular locations from UniProtKB/Swiss-Prot for MLIP Gene

Nucleus. Nucleus envelope. Nucleus, PML body.

Gene Ontology (GO) - Cellular Components for MLIP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus --
GO:0005635 nuclear envelope ISS --
GO:0016605 PML body ISS --
GO:0031981 nuclear lumen ISS --
genes like me logo Genes that share ontologies with MLIP: view

No data available for Subcellular locations from COMPARTMENTS for MLIP Gene

Pathways for MLIP Gene

SuperPathways for MLIP Gene

No Data Available

Interacting Proteins for MLIP Gene

STRING Interaction Network Preview (showing 1 interactants - click image to see details)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000274897%0d%0a9606.ENSP00000357283%0d%0a
Selected Interacting proteins: ENSP00000274897 for MLIP Gene via STRING

Symbol External ID(s) Details
LMNA

Gene Ontology (GO) - Biological Process for MLIP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000122 negative regulation of transcription from RNA polymerase II promoter IEA --
GO:0010614 negative regulation of cardiac muscle hypertrophy IEA --
genes like me logo Genes that share ontologies with MLIP: view

No data available for Pathways by source for MLIP Gene

Transcripts for MLIP Gene

Unigene Clusters for MLIP Gene

Muscular LMNA-interacting protein:
Representative Sequences:

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for MLIP

Primer Products

  • OriGene qSTAR qPCR primer pairs in human,mouse,rat for MLIP
  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for MLIP Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6a · 6b ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12a · 12b ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18
SP1: - - - - -
SP2: - - -
SP3: - - - - - - - - - -
SP4: - - - -
SP5: - - -
SP6: - - - - -
SP7: -

Relevant External Links for MLIP Gene

GeneLoc Exon Structure for
MLIP
ECgene alternative splicing isoforms for
MLIP

Expression for MLIP Gene

mRNA expression in normal human tissues for MLIP Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for MLIP Gene

This gene is overexpressed in Muscle - Skeletal (18.0), Heart - Left Ventricle (14.7), Nerve - Tibial (7.3), and Heart - Atrial Appendage (7.2).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for MLIP Gene

SOURCE GeneReport for Unigene cluster for MLIP Gene Hs.591803

mRNA Expression by UniProt/SwissProt for MLIP Gene

Q5VWP3-MLIP_HUMAN
Tissue specificity: Primarily expressed in heart and skeletal muscle. Also detected in liver.
genes like me logo Genes that share expressions with MLIP: view

In Situ Assay Products

Orthologs for MLIP Gene

This gene was present in the common ancestor of chordates.

Orthologs for MLIP Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia MLIP 35
  • 95.26 (n)
  • 93.21 (a)
MLIP 36
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia MLIP 35
  • 80 (n)
  • 72.46 (a)
MLIP 36
  • 31 (a)
OneToOne
dog
(Canis familiaris)
Mammalia LOC474943 35
  • 85.44 (n)
  • 80.28 (a)
MLIP 36
  • 38 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Mlip 35
  • 81.67 (n)
  • 72.51 (a)
Mlip 16
Mlip 36
  • 69 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia MLIP 36
  • 29 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia MLIP 36
  • 24 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Mlip 35
  • 78.88 (n)
  • 70.35 (a)
chicken
(Gallus gallus)
Aves MLIP 36
  • 46 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia MLIP 36
  • 21 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii CU571255.1 36
  • 9 (a)
OneToOne
Species with no ortholog for MLIP:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for MLIP Gene

ENSEMBL:
Gene Tree for MLIP (if available)
TreeFam:
Gene Tree for MLIP (if available)

Paralogs for MLIP Gene

No data available for Paralogs for MLIP Gene

Variants for MLIP Gene

Sequence variations from dbSNP and Humsavar for MLIP Gene

SNP ID Clin Chr 06 pos Sequence Context AA Info Type MAF
rs484196 -- 54,128,669(+) ggaaa(A/G)ggagg intron-variant
rs485026 -- 54,098,140(+) GGGAT(C/T)TTTCt intron-variant, upstream-variant-2KB
rs486135 -- 54,114,019(+) ACTGG(G/T)TCCTC intron-variant
rs490628 -- 54,104,112(-) ATTCG(A/G)CTGAA intron-variant
rs494180 -- 54,131,115(-) acaac(A/G)gaaaa intron-variant

Structural Variations from Database of Genomic Variants (DGV) for MLIP Gene

Variant ID Type Subtype PubMed ID
dgv1955e1 CNV Complex 17122850
nsv5307 CNV Loss 18451855
nsv517189 CNV Loss 19592680
nsv526401 CNV Loss 19592680
nsv523301 CNV Loss 19592680
nsv7901 CNV Gain 18304495
nsv823690 CNV Gain 20364138
nsv823691 CNV Gain 20364138
nsv885885 CNV Loss 21882294
dgv119n17 CNV Loss 16327808
esv34853 CNV Gain 17911159
esv5367 CNV Complex 18987735
dgv1116e199 CNV Deletion 23128226
esv2732099 CNV Deletion 23290073
nsv508407 CNV Loss 20534489
esv5312 CNV Deletion 18987735
dgv53n50 CNV Loss 21212237
nsv514360 CNV Loss 21397061
dgv1045n67 CNV Loss 20364138
nsv821284 CNV Deletion 20802225
nsv820018 CNV Gain 19587683
dgv1117e199 CNV Deletion 23128226
esv990236 CNV Deletion 20482838
esv26113 CNV Gain 19812545
dgv1046n67 CNV Gain 20364138
esv2421881 CNV Deletion 20811451
essv8257 CNV CNV 17122850
essv5979 CNV CNV 17122850
nsv885886 CNV Loss 21882294
nsv885887 CNV Loss 21882294
nsv823699 CNV Gain 20364138
nsv507330 CNV Insertion 20534489

Relevant External Links for MLIP Gene

HapMap Linkage Disequilibrium report
MLIP

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MLIP Gene

Disorders for MLIP Gene

No disorders were found for MLIP Gene.

No data available for UniProtKB/Swiss-Prot for MLIP Gene

Publications for MLIP Gene

  1. Identification of a novel muscle enriched A-type Lamin interacting protein (MLIP). (PMID: 21498514) Ahmady E. … Burgon P.G. (J. Biol. Chem. 2011) 2 3 4
  2. The DNA sequence and analysis of human chromosome 6. (PMID: 14574404) Mungall A.J. … Beck S. (Nature 2003) 3 4
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  5. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PMID: 16344560) Kimura K. … Sugano S. (Genome Res. 2006) 3

Products for MLIP Gene

Sources for MLIP Gene

Back to Top

Content