MLIP Gene
protein-coding GIFtS : 41
GCID: GC06 P053796
muscular LMNA-interacting protein (Previous name: chromosome 6 open reading frame 142 ) (Previous symbol: C6orf142 )
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Aliasesfor MLIP gene
(According to
1 HGNC ,
2 Entrez Gene ,
3 UniProtKB/Swiss-Prot ,
4 UniProtKB/TrEMBL , 5 OMIM , 6 GeneLoc ,
7 Ensembl ,
8 DME ,
9 miRBase ,
and/or 10 fRNAdb )About This Section Aliases Muscular LMNA-Interacting Protein 1 2 C6orf1421 2 3 Muscular-Enriched A-Type Laminin-Interacting Protein2 3 MGC182571 Chromosome 6 Open Reading Frame 1421 Muscle-Enriched A-Type Lamin Interacting Protein2
Export aliases for MLIP gene to outside databases
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Summariesfor MLIP gene (According to Entrez Gene ,
Tocris Bioscience ,
Wikipedia's
Gene Wiki ,
PharmGKB ,
UniProtKB/Swiss-Prot ,
and/or
UniProtKB/TrEMBL )
About This Section Gene Wiki entry for MLIP (C6orf142)
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Genomic Viewsfor MLIP gene
(According to
GeneLoc and/or
HGNC , and/or
Entrez Gene (NCBI build 37) ,
and/or miRBase ,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69) ,
Regulatory elements and Epigenetics data according to
QIAGEN ,
SABiosciences , and/or
SwitchGear Genomics )About This Section RefSeq DNA sequence: NC_000006.11 NC_018917.1 NT_007592.15 Regulatory elements: Search SABiosciences Regulatory transcription factor binding sites for MLIP Other transcription factors Search SABiosciences Chromatin IP Primers for MLIP Epigenetics: QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat MLIP
Genomic Location: Genomic View : UCSC Golden Path with GeneCards custom track Entrez Gene cytogenetic band: 6p12.1 Ensembl cytogenetic band: 6p12.1 HGNC cytogenetic band: 6p12.2-p12.1 MLIP Gene in genomic location: bands according to Ensembl, locations according to
(and/or Entrez Gene and/or Ensembl if different) GeneLoc information about chromosome 6 GeneLoc Exon Structure
GeneLoc location for GC06P053796: view genomic region
(about GC identifiers )
Start:
53,794,780 bp from pter
End:
54,131,078 bp from pter
Size:
336,299 bases
Orientation:
plus strand
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Proteinsfor MLIP gene
(According to
1 UniProtKB ,
HORDE ,
neXtProt ,
Ensembl ,
and/or Reactome ,
Modification sites according to 2 PhosphoSitePlus ,
Specific Peptides from DME ,
Protein expression images according to data from SPIRE MOPED and PaxDb ,
RefSeq according to NCBI ,
PDB rendering according to OCA and/or Proteopedia ,
Recombinant Proteins
from
EMD Millipore ,
R&D Systems ,
GenScript ,
Enzo Life Sciences ,
OriGene ,
Novus Biologicals ,
Sino Biological ,
ProSpec , and/or
Uscn ,
Biochemical Assays by
EMD Millipore ,
R&D Systems ,
OriGene ,
GenScript ,
Cell Signaling Technology ,
Enzo Life Sciences , and/or
Uscn ,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene ,
Antibodies by
EMD Millipore ,
R&D Systems ,
GenScript ,
Cell Signaling Technology ,
OriGene ,
Novus Biologicals ,
Thermo Fisher Scientific ,
Abcam , and/or
Uscn )
About This Section UniProtKB/Swiss-Prot: MLIP_HUMAN, Q5VWP3 (See
protein sequence )Recommended Name: Muscular LMNA-interacting protein Size : 458 amino acids; 50429 Da
Subunit : Interacts with LMNA; may regulate MLIP localization to the nucleus envelope
Subcellular location : Nucleus (By similarity). Nucleus envelope (By similarity). Nucleus, PML body (By similarity)
Sequence caution : Sequence=CAI13927.1; Type=Erroneous gene model prediction;
Secondary accessions : B7Z2N0 Q96H08 Q96NF7Alternative splicing : 3 isoforms : Q5VWP3-1 Q5VWP3-2 Q5VWP3-3 (No experimental confirmation available)Explore the universe of human proteins at neXtProt for MLIP: NX_Q5VWP3 Post-translational modifications:
View modification sites using PhosphoSitePlus 2 View neXtProt modification sites for NX_Q5VWP3 MLIP Protein expression data from MOPED and PaxDb : About this image
REFSEQ proteins: NP_612636.2 ENSEMBL proteins: ENSP00000423191 ENSP00000274897 ENSP00000425142 ENSP00000359914 ENSP00000427584 ENSP00000421727 ENSP00000359913 ENSP00000411917 ENSP00000427057 ENSP00000426830 ENSP00000426290 ENSP00000421444 ENSP00000351019 Human Recombinant Protein Products: Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view) : About this table
MLIP for ontologies About GeneDecksing MLIP Antibody Products: Assay Products for MLIP:
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Protein
Domains / Familiesfor MLIP gene (According to InterPro , ProtoNet ,
UniProtKB , and/or BLOCKS ,
Sets of similar genes according to GeneDecks )
About This Section ProtoNet protein and cluster: Q5VWP3
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Functionfor MLIP gene
(According to 1 UniProtKB ,
Genatlas ,
LifeMap Discovery™ ,
IUBMB , and/or
2 DME ,
Human phenotypes from GenomeRNAi ,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences ,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene ,
RNAi from
EMD Millipore ,
siRNAs from
OriGene ,
QIAGEN ,
microRNA from QIAGEN ,
Gene Editing from DNA2.0 ,
Clones from EMD Millipore ,
OriGene ,
SwitchGear Genomics ,
GenScript ,
Sino Biological ,
DNA2.0 ,
and Vector BioLabs ,
Cell Lines from GenScript ,
LifeMap BioReagents ,
In Situ Hybridization Assays from Advanced Cell Diagnostics ,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene .)
About This Section Clone Products: Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human , mouse , rat for MLIP (see all 2 ) OriGene untagged cDNA clones in CMV expression vector in human , mouse , rat for MLIPOriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling GenScript Custom all cDNA clones Services for MLIP Browse Sino Biological Human cDNA Clones DNA2.0 Custom Codon Optimized Gene
Synthesis Service for MLIP Vector BioLabs ready-to-use adenovirus/AAV for human , mouse , rat MLIP
In Situ Assay Products: Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MLIP
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Pathways & Interactionsfor MLIP gene
(Pathways according to
EMD Millipore ,
R&D Systems ,
Cell Signaling Technology ,
KEGG ,
PharmGKB ,
BioSystems ,
Reactome ,
Tocris Bioscience ,
GeneGo (Thomson Reuters) ,
QIAGEN ,
and/or UniProtKB ,
Sets of similar genes according to GeneDecks ,
Interaction Networks according to
SABiosciences ,
and/or STRING ,
Interactions according to 1 UniProtKB ,
2 MINT ,
3 I2D , and/or
4 STRING ,
with links to IntAct and
Ensembl ,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene) .
About This Section Interactions: Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for MLIP STRING Interaction
Network Preview (showing 1 interactants - click image to see more details)1 Interacting protein for MLIP (ENSP00000274897 4 ) via UniProtKB, MINT, STRING , and/or I2D About this table
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Drugs & Compoundsfor MLIP gene (Chemical Compounds according to UniProtKB , Enzo Life Sciences ,
EMD Millipore , Tocris Bioscience
HMDB ,
BitterDB , and/or
Novoseek , and Drugs according to
DrugBank ,
Enzo Life Sciences , and/or
PharmGKB , with drugs/clinical trials/news
search links to CenterWatch )
About This Section Browse Tocris compounds for MLIP Search CenterWatch for drugs/clinical trials and news about MLIP
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Transcriptsfor MLIP gene (Secondary structures according to
fRNAdb ,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank , RefSeq according to Entrez Gene ,
DOTS (version 10), and/or
AceView ,
transcript ids from Ensembl
with links to UCSC ,
exon structure from GeneLoc ,
alternative splicing isoforms according to ASD and/or
ECgene ,
RNAi Products from
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siRNAs from
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QIAGEN ,
shRNA from
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microRNA from QIAGEN ,
Tagged/untagged cDNA clones from
OriGene ,
SwitchGear Genomics ,
GenScript ,
DNA2.0 ,
Vector BioLabs ,
Primers from
OriGene ,
SABiosciences , and/or
QIAGEN
)About This Section REFSEQ mRNAs for MLIP gene: NM_138569.2 Unigene Cluster for MLIP:
Muscular LMNA-interacting protein Hs.591803 [show with all ESTs ] Unigene Representative Sequence: BX647567 14 Ensembl transcripts including schematic representations, and UCSC links where relevant : ENST00000505762 ENST00000274897 (uc003pcg.4 ) ENST00000514921 (uc003pcf.2 )ENST00000370877 ENST00000509997 ENST00000460844 ENST00000370876 (uc003pch.4 )ENST00000447836 ENST00000511678 ENST00000503951 ENST00000511744 (uc011dwz.1 )ENST00000502396 (uc011dxa.2 ) ENST00000514433 ENST00000358276 Clone Products: OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human , mouse , rat for MLIP (see all 2 ) OriGene untagged cDNA clones in CMV expression vector in human , mouse , rat for MLIPOriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling GenScript Custom all cDNA clones Services for MLIP DNA2.0 Custom Codon Optimized Gene
Synthesis Service for MLIP Vector BioLabs ready-to-use adenovirus/AAV for human , mouse , rat MLIP
Additional cDNA sequence: AK055530.1 AK294797.1 AK294890.1 AK311190.1 AK316157.1 BC009010.1 BX647567.1
6 DOTS entries : DT.110744 DT.101974426
DT.91834423 DT.97769916 DT.92420692 DT.99972061 24/47 AceView cDNA sequences (see all 47 ):
R57594 N59308 AI361445 BX091237 BC009010 AA410441 AW444530 AA495808 BX647567 AI688707 N45572 BX113168 AK056584 AA406430 C05218 CB265414 BG182708 AL694840 AK055530 BF939486 AI797746 BG185854 BQ067018 BX640790 GeneLoc Exon Structure 5/7 Alternative Splicing Database (ASD) splice patterns (SP) for MLIP (see all 7 ) About this scheme ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6a · 6b ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12a · 12b ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18 SP1 :   -   -   -         -                   -         SP2 :   -   -   -                                   SP3 :     -   -   -       -   -   -   -   -           -   -       SP4 :               -   -     -   -                   SP5 :               -       -   -                  
ECgene alternative splicing isoforms for MLIP
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Expression for MLIP gene
(RNA expression data according to
H-InvDB ,
NONCODE ,
miRBase , and
RNAdb ,
Expression images according to data from
BioGPS ,
Illumina Human BodyMap , and
CGAP
SAGE ,
Sets of similar genes according to GeneDecks ,
in vivo and in vitro expression data from LifeMap Discovery™ ,
plus additional links to
Genevestigator , and/or
SOURCE , and/or
BioGPS , and/or
UniProtKB ,
PCR Arrays from
SABiosciences ,
Primers from
OriGene ,
SABiosciences , and/or
QIAGEN ,
In Situ Hybridization Assays from Advanced Cell Diagnostics )
About This Section MLIP expression in normal human tissues (normalized intensities) See probesets specificity/sensitivity at GeneAnnot About this image BioGPS CGAP TAG: AAGCTCTTGA
About this image MLIP expression in embryonic tissues and stem cells Expression by the Database of Embryonic development, Stem cell research, and
Regenerative medicine About this table See MLIP Protein Expression from SPIRE MOPED and PaxDB Genevestigator expression for MLIP SOURCE GeneReport for Unigene cluster: Hs.591803 UniProtKB/Swiss-Prot: MLIP_HUMAN, Q5VWP3 Tissue specificity : Primarily expressed in heart and skeletal muscle. Also detected in liver SABiosciences Custom PCR Arrays for MLIP Primer Products: OriGene genome-wide validated SYBR primer pairs in human , mouse , rat for MLIPBrowse OriGene validated miRNA SYBR primer pairs SABiosciences RT2 qPCR Primer Assay in human , mouse / rat MLIP QIAGEN QuantiTect SYBR Green Assays in human , mouse , rat MLIP QIAGEN QuantiFast Probe-based Assays in human , mouse , rat MLIP In Situ Assay Products: Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MLIP
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Orthologsfor MLIP gene
(Orthologs according to
1,2 HomoloGene (2 older version, for species not in 1 newer version),
3 euGenes ,
4 SGD
,
5 MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase ,
and/or
6 Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam )
About This Section
This gene was present in the common ancestor of chordates.
Orthologs for MLIP gene from 4/8 species (see all 8 ) About this table
ENSEMBL Gene Tree for MLIP (if available)TreeFam Gene Tree for MLIP (if available)
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Paralogsfor MLIP gene (Paralogs according to
1 HomoloGene , 2 Ensembl , and 3 SIMAP , Pseudogenes according to 4 Pseudogene.org Build 68)About This Section --
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Genomic Variantsfor MLIP gene (SNPs/Variants according to the
1 NCBI SNP Database ,
2 Ensembl ,
3 PupaSUITE ,
UniProtKB , and
DNA2.0 ,
Linkage Disequilibrium by HapMap ,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants , Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB) , Blood group antigen gene mutations by BGMUT ,
Resequencing Primers from QIAGEN ,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences )
About This Section
Genomic Data Transcription Related Data Allele Frequencies SNP ID Valid Clinical significance Chr 6 pos Sequence # AA Chg Type More # Allele freq Pop Total sample More
HapMap Linkage Disequilibrium report for MLIP (53794780 - 54044780 bp, first 250kb of MLIP)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions) Database of Genomic Variants (DGV) variations for MLIP: --
SABiosciences Cancer Mutation PCR Assays
QIAGEN SeqTarget long-range PCR primers in human , mouse , rat for resequencing MLIP
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Disorders
/ Diseasesfor MLIP gene
(in which this Gene is Involved, According to MalaCards ,
OMIM, UniProtKB ,
the University of Copenhagen DISEASES
database ,
Genatlas , GeneTests ,
GAD ,
HuGE Navigator ,
and/or TGDB .)
About This Section
MLIP for disorders About GeneDecksing
OMIM gene information: 614106
OMIM disorders : --4 diseases for MLIP : About MalaCards nijmegen breakage syndrome psoriatic arthritis hodgkin's lymphoma arthritis Export disorders for MLIP gene to outside databases
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Publicationsfor MLIP gene (in
PubMed .
Associations of this gene to articles via
1 Entrez Gene ,
2 UniProtKB/Swiss-Prot ,
3 HGNC ,
4 GAD ,
5 PharmGKB ,
6 HMDB ,
7 DrugBank ,
8 UniProtKB/TrEMBL ,
9 Novoseek , and/or
10 fRNAdb )
About This Section PubMed articles for MLIP gene, integrated from 9 sources (see all 13 ): (articles sorted by number of sources associating them with MLIP) Utopia : connect your pdf to the dynamic world of online information
Identification of a novel muscle enriched A-type Lamin interacting protein (MLIP). (PubMed id 21498514) 1 , 2 , 3 Ahmady E....Burgon P.G. (2011) The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334) 1 , 2 Gerhard D.S....Malek J. (2004) Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039) 1 , 2 Ota T.... Sugano S. (2004) The DNA sequence and analysis of human chromosome 6. (PubMed id 14574404) 1 , 2 Mungall A.J.... Beck S. (2003) Genome-wide association study identifies loci influenc ing concentrations of liver enzymes in plasma. (PubMed id 22001757) 1 Chambers J.C....Kooner J.S. (2011) Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614) 1 Rose J.E....Uhl G.R. (2010) Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560) 1 Kimura K.... Sugano S. (2006) T-cell variant of classical Hodgkin's lymphoma with nodal and cutaneous manifestations demonstrated by single-cell polymerase chain reaction. (PubMed id 12218070) 1 Willenbrock K....Hansmann M.L. (2002) Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932) 1 Strausberg R.L....Marra M.A. (2002) Psoriatic arthritis joint fluids are characterized by CD8 and CD4 T cell clonal expansions appear antigen driven. (PubMed id 11160357) 1 Costello P.J....FitzGerald O.M. (2001)
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External Searches for MLIP gene
(in PubMed ,
OMIM , and NCBI Bookshelf ) About This Section
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Genome Databases showing MLIP gene
(According to
Entrez Gene ,
HGNC ,
AceView ,
euGenes ,
Ensembl ,
miRBase ,
ECgene ,
Kegg ,
and/or
H-InvDB )
About This Section
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Other Databases showing MLIP gene
(According to HUGE )
About This Section --
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Specialized Databases showing MLIP gene (According to PharmGKB ,
ATLAS , HORDE , IMGT , LEIDEN , UniProtKB/Swiss-Prot , and/or UniProtKB/TrEMBL ,Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot )About This Section
Name Description
PharmGKB entry for MLIP Pharmacogenomics, SNPs, Pathways
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About This Section Patent Information for MLIP gene: Search GeneIP for patents involving MLIP GeneCards and IP: Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
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Productsfor MLIP gene (Antibodies, recombinant proteins, and assays from EMD Millipore , R&D Systems , OriGene , QIAGEN , GenScript , Cell Signaling Technology , SABiosciences , Novus Biologicals , Sino Biological , Enzo Life Sciences , Abcam , ProSpec , Uscn , Thermo Fisher Scientific , Gene Editing from DNA2.0 , Clones from EMD Millipore , OriGene , GenScript , Sino Biological , DNA2.0 , SwitchGear Genomics , Vector BioLabs , Cell lines from GenScript and LifeMap BioReagents , PCR Arrays from SABiosciences , Drugs and/or compounds from EMD Millipore , Tocris Bioscience , and/or
Enzo Life Sciences ), In Situ Hybridization Assays from Advanced Cell Diagnostics About This Section
Browse OriGene Antibodies OriGene shRNA RFP for MLIP OriGene 29mer shRNA kits in GFP-retroviral vector in human , mouse , rat for MLIP OriGene genome-wide validated SYBR primer pairs in human , mouse , rat for MLIP OriGene Protein Over-expression Lysate for MLIP Browse OriGene Fluorogenic Cell Assay Kits OriGene siRNA for MLIP OriGene 3'-UTR Clone for MLIP OriGene untagged cDNA clones in CMV expression vector in human , mouse , rat for MLIP OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human , mouse , rat for MLIP Browse OriGene GFP tagged cDNA clones in CMV expression vector Browse OriGene MicroRNA Expression Plasmids Browse OriGene basic RS shRNAs Browse OriGene validated miRNA SYBR primer pairs OriGene Purified Protein for MLIP OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling OriGene Custom Antibody Services for MLIP OriGene Custom Protein Services for MLIP OriGene Custom Immunoassay Development
QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat MLIP QIAGEN SeqTarget long-range PCR primers in human , mouse , rat for resequencing MLIP QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat MLIP QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human , mouse , rat MLIP QIAGEN QuantiFast Probe-based Assays in human , mouse , rat MLIP QIAGEN QuantiTect SYBR Green Assays in human , mouse , rat MLIP
Search Tocris compounds for MLIP
MLIP Proteins, Antibodies, CLIAs, and ELISAs
Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MLIP
Search ThermoFisher Antibodies for MLIP
Vector BioLabs ready-to-use adenovirus/AAV for human , mouse , rat MLIP
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Aliases for MLIP
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Expression for MLIP
Function for MLIP
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