Aliases for MLF2 Gene
Aliases for MLF2 Gene
External Ids for MLF2 Gene
- HGNC: 7126
- Entrez Gene: 8079
- Ensembl: ENSG00000089693
- OMIM: 601401
- UniProtKB: Q15773
Previous GeneCards Identifiers for MLF2 Gene
- GC12P006734
- GC12P006859
- GC12M006553
- GC12M006857
Summaries for MLF2 Gene
GeneCards Summary for MLF2 Gene
MLF2 (Myeloid Leukemia Factor 2) is a Protein Coding gene. Diseases associated with MLF2 include Myeloid Leukemia. An important paralog of this gene is MLF1.
No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MLF2 Gene
Genomics for MLF2 Gene
Regulatory Elements for MLF2 Gene
Enhancers for MLF2 Gene
| GeneHancer Identifier | Score | Enhancer Sources | TSS distance (kb) | Number of Genes Away | Size (kb) | Transcription Factor Binding Sites within enhancer | Other Gene Targets for Enhancer |
|---|
Enhancers around MLF2 on UCSC Golden Path with GeneCards custom track
Promoters for MLF2 Gene
| Ensembl Regulatory Elements (ENSRs) | TSS Distance (bp) | Size (bp) | Binding Sites for Transcription Factors within promoters |
|---|
ENSRs around MLF2 on UCSC Golden Path with GeneCards custom track
- Transcription factor binding sites by QIAGEN in the MLF2 gene promoter:
Regulatory Element Products
Genomic Location for MLF2 Gene
- Chromosome:
- 12
- Start:
- 6,747,992 bp from pter
- End:
- 6,767,475 bp from pter
- Size:
- 19,484 bases
- Orientation:
- Minus strand
Genomic View for MLF2 Gene
Genes around MLF2 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 12p13.31 by Ensembl
- 12p13 by Entrez Gene
- 12p13.31 by HGNC
MLF2 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for MLF2 Gene
Proteins for MLF2 Gene
-
Protein details for MLF2 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q15773-MLF2_HUMAN
- Recommended name:
- Myeloid leukemia factor 2
- Protein Accession:
- Q15773
Protein attributes for MLF2 Gene
- Size:
- 248 amino acids
- Molecular mass:
- 28147 Da
- Quaternary structure:
- No Data Available
Protein Expression for MLF2 Gene
Post-translational modifications for MLF2 Gene
Other Protein References for MLF2 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- Novus Biologicals Antibodies for MLF2
- Search GeneTex for Antibodies for MLF2
-
Santa Cruz Biotechnology (SCBT) Antibodies for MLF2
Protein Products
-
OriGene Purified Proteins for MLF2
- Search Origene for MassSpec and Protein Over-expression Lysates for MLF2
- Origene Custom Protein Services for MLF2
- Search GeneTex for Proteins for MLF2
Assay Products
No data available for DME Specific Peptides for MLF2 Gene
Domains & Families for MLF2 Gene
Protein Domains for MLF2 Gene
- InterPro:
- ProtoNet:
Suggested Antigen Peptide Sequences for MLF2 Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
Q15773- Family:
-
- Belongs to the MLF family.
No data available for Gene Families for MLF2 Gene
Function for MLF2 Gene
Molecular function for MLF2 Gene
- GENATLAS Biochemistry:
- myelodysplasia/myeloid leukemia factor 2,cytoplasmic,ubiquitously expressed currently no evidence for the involvement of MLF2 in hematologic malignancies
Phenotypes for MLF2 Gene
- GenomeRNAi human phenotypes for MLF2:
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
-
ViGene Biosciences lentiviral particle packaged cDNA for MLF2 gene
-
ViGene Biosciences ready-to-package AAV shRNAs for MLF2 gene
- Search ViGene Biosciences for MLF2
CRISPR Products
-
OriGene CRISPR knockouts for MLF2
-
Santa Cruz Biotechnology (SCBT) CRISPR for MLF2
- GenScript: Design CRISPR guide RNA sequences for MLF2
miRNA for MLF2 Gene
- miRTarBase miRNAs that target MLF2
-
- hsa-mir-744-5p (MIRT037535)
- hsa-mir-296-3p (MIRT038370)
- hsa-mir-92a-3p (MIRT049518)
- hsa-mir-16-5p (MIRT051088)
- hsa-mir-3679-3p (MIRT655710)
- hsa-mir-6826-3p (MIRT655711)
- hsa-mir-4662a-5p (MIRT655712)
- hsa-mir-6756-3p (MIRT655713)
- hsa-mir-3127-3p (MIRT655714)
- hsa-mir-6507-3p (MIRT655715)
- hsa-mir-4282 (MIRT655716)
miRNA Products
- Search ViGene Biosciences for MLF2
Clone Products
- OriGene clones in human for MLF2
- OriGene ORF clones in human,mouse,rat for MLF2
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Sino Biological Human cDNA Clone for MLF2
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
Cell Line Products
-
ViGene Biosciences adenoviral particle packaged cDNA for MLF2 gene
-
ViGene Biosciences lentiviral particle packaged cDNA for MLF2 gene
-
ViGene Biosciences ready-to-package AAV shRNAs for MLF2 gene
Flow Cytometry Products
No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for MLF2 Gene
Localization for MLF2 Gene
Subcellular locations from UniProtKB/Swiss-Prot for MLF2 Gene
- Cytoplasm. Nucleus.
| Compartment | Confidence |
|---|---|
| nucleus | 5 |
| cytosol | 4 |
| plasma membrane | 2 |
| extracellular | 1 |
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005737 | cytoplasm | IEA | -- |
Pathways & Interactions for MLF2 Gene
More details on SuperPathways for MLF2
No Data Available
Interacting Proteins for MLF2 Gene
Selected Interacting proteins:
Q15773-MLF2_HUMAN
ENSP00000203630
for MLF2 Gene via
MINT
STRING
UniProtKB
I2D
No data available for Pathways by source and SIGNOR curated interactions for MLF2 Gene
Transcripts for MLF2 Gene
mRNA/cDNA for MLF2 Gene
- (1) REFSEQ mRNAs :
- (10) Additional mRNA sequences :
- (725) Selected AceView cDNA sequences:
- (11) Ensembl transcripts including schematic representations, and UCSC links where relevant :
Unigene Clusters for MLF2 Gene
CRISPR Products
-
OriGene CRISPR knockouts for MLF2
-
Santa Cruz Biotechnology (SCBT) CRISPR for MLF2
- GenScript: Design CRISPR guide RNA sequences for MLF2
miRNA Products
- Search ViGene Biosciences for MLF2
Clone Products
- OriGene clones in human for MLF2
- OriGene ORF clones in human,mouse,rat for MLF2
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Sino Biological Human cDNA Clone for MLF2
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
Flow Cytometry Products
| ExUns: | 1a | · | 1b | · | 1c | · | 1d | ^ | 2a | · | 2b | ^ | 3a | · | 3b | ^ | 4 | ^ | 5 | ^ | 6a | · | 6b | ^ | 7a | · | 7b | ^ | 8a | · | 8b | ^ | 9a | · | 9b |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | - | - | - | ||||||||||||||||||||||||||||||||
| SP2: | - | ||||||||||||||||||||||||||||||||||
| SP3: | - | - | - | - | - | - | - | ||||||||||||||||||||||||||||
| SP4: | - | - | - | - | - | - | - | ||||||||||||||||||||||||||||
| SP5: | |||||||||||||||||||||||||||||||||||
| SP6: | - |
Expression for MLF2 Gene
This gene is overexpressed in Neutrophil (33.9), Platelet (9.8), and Retina (6.5).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for MLF2 Gene
SOURCE GeneReport for Unigene cluster for MLF2 Gene Hs.524214
mRNA Expression by UniProt/SwissProt for MLF2 Gene
Q15773-MLF2_HUMAN
Tissue specificity:
Ubiquitously expressed.
Primer Products
-
OriGene qPCR primer pairs for MLF2
-
OriGene qPCR primer pairs and template standards for MLF2
No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA differential expression in normal tissues for MLF2 Gene
Orthologs for MLF2 Gene
This gene was present in the common ancestor of animals.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| cow (Bos Taurus) |
Mammalia | MLF2 35 |
|
||
| MLF2 36 |
|
OneToOne | |||
| dog (Canis familiaris) |
Mammalia | MLF2 35 |
|
||
| MLF2 36 |
|
OneToOne | |||
| mouse (Mus musculus) |
Mammalia | Mlf2 35 |
|
||
| Mlf2 16 |
|
||||
| Mlf2 36 |
|
OneToOne | |||
| chimpanzee (Pan troglodytes) |
Mammalia | MLF2 35 |
|
||
| MLF2 36 |
|
OneToOne | |||
| rat (Rattus norvegicus) |
Mammalia | Mlf2 35 |
|
||
| oppossum (Monodelphis domestica) |
Mammalia | MLF2 36 |
|
OneToOne | |
| platypus (Ornithorhynchus anatinus) |
Mammalia | MLF2 36 |
|
OneToOne | |
| chicken (Gallus gallus) |
Aves | MLF2 35 |
|
||
| MLF2 36 |
|
OneToOne | |||
| lizard (Anolis carolinensis) |
Reptilia | MLF2 36 |
|
OneToOne | |
| tropical clawed frog (Silurana tropicalis) |
Amphibia | mlf2 35 |
|
||
| Str.1911 35 |
|
||||
| zebrafish (Danio rerio) |
Actinopterygii | mlf2 35 |
|
||
| wufj39f09 35 |
|
||||
| mlf2 36 |
|
OneToOne | |||
| rainbow trout (Oncorhynchus mykiss) |
Actinopterygii | Omy.10102 35 |
|
||
| fruit fly (Drosophila melanogaster) |
Insecta | Mlf 36 |
|
OneToMany |
- Species with no ortholog for MLF2:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea squirt (Ciona intestinalis)
- sea squirt (Ciona savignyi)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- wheat (Triticum aestivum)
- worm (Caenorhabditis elegans)
Paralogs for MLF2 Gene
(2) SIMAP similar genes for MLF2 Gene using alignment to 5 proteins:
Pseudogenes.org Pseudogenes for MLF2 Gene
Variants for MLF2 Gene
| SNP ID | Clin | Chr 12 pos | Sequence Context | AA Info | Type |
|---|---|---|---|---|---|
| VAR_036429 | A colorectal cancer sample | ||||
| rs13402 | -- | 6,753,008(-) | GCCGC(C/G)ACCCT | nc-transcript-variant, upstream-variant-2KB | |
| rs7301568 | -- | 6,748,998(+) | CAGAG(C/T)GGACA | intron-variant | |
| rs12827345 | -- | 6,750,717(+) | CCATG(G/T)TTCCA | nc-transcript-variant, reference, missense | |
| rs2178695 | -- | 6,747,834(+) | ACCTG(C/G)CAGTG | downstream-variant-500B |
Residual Variation Intolerance Score:
48.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
0.68;
14.54% of all genes are more intolerant (likely to be disease-causing)
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for MLF2 Gene
Disorders for MLF2 Gene
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| myeloid leukemia |
|
|
Search MLF2 in MalaCards
View complete list of genes associated with diseases
Relevant External Links for MLF2
No data available for UniProtKB/Swiss-Prot and Genatlas for MLF2 Gene
Publications for MLF2 Gene
- cDNA cloning, tissue distribution, and chromosomal localization of myelodysplasia/myeloid leukemia factor 2 (MLF2). (PMID: 8661158) Kuefer M.U. … Morris S.W. (Genomics 1996) 2 3 4 67
- Proteomic analysis and identification of cellular interactors of the giant ubiquitin ligase HERC2. (PMID: 25476789) Galligan J.T. … Howley P.M. (J. Proteome Res. 2015) 3
- Characterization of the Cardiac Overexpression of HSPB2 Reveals Mitochondrial and Myogenic Roles Supported by a Cardiac HspB2 Interactome. (PMID: 26465331) Grose J.H. … Benjamin I.J. (PLoS ONE 2015) 3
- A human interactome in three quantitative dimensions organized by stoichiometries and abundances. (PMID: 26496610) Hein M.Y. … Mann M. (Cell 2015) 3
- A deep proteomics perspective on CRM1-mediated nuclear export and nucleocytoplasmic partitioning. (PMID: 26673895) KA+rlA+ K. … GAPrlich D. (Elife 2015) 3
Products for MLF2 Gene
- Browse R&D Systems for Antibodies
- Browse R&D Systems for Human Recombinant Proteins
- Browse R&D Systems for biochemical assays
- Browse Primary Antibodies
- Browse Proteins and Enzymes
- Browse ELISAs
- Browse Activity Assays
- Browse cDNA Clones
- Browse Cell Culture Products
- Browse Cell Selection and Detection Kits
- Browse DNA Damage and Repair Kits
- Browse ELISpot/FluoroSpot Kits and Development Modules
- Browse Flow Cytometry Kits
- Browse Immunoprecipitation Assays
- Browse Luminex Assays
- Browse Peptides
- Browse Proteome Profiler Antibody Arrays
- Browse Small Molecules
- Custom Antibody ServicesOriGene Antibodies for MLF2
- Browse OriGene ELISA Kits
- Custom Assay Services
- OriGene Purified Proteins for MLF2
- Search Origene for MassSpec and Protein Over-expression Lysates for MLF2
- Origene Custom Protein Services for MLF2
- Origene siRNA, shRNA, mouse_rna, rat_shrna, and RNAi products in human, mouse, rat for MLF2
- Browse OriGene Inhibitory RNA Products For MLF2
- OriGene qPCR primer pairs for MLF2
- OriGene qPCR primer pairs and template standards for MLF2
- OriGene CRISPR knockouts for MLF2
- OriGene clones in human for MLF2
- OriGene ORF clones in human,mouse,rat for MLF2
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- GenScript: Next-day shipping cDNA clones in your preferred vector
- GenScript Custom Purified and Recombinant Proteins Services for MLF2
- GenScript Custom Assay Services for MLF2
- GenScript Custom overexpressing Cell Line Services for MLF2
- GenScript: Design CRISPR guide RNA sequences for MLF2
- Design optimal peptide antigens
- CloneReady with Over 120,000 Genes
- Gene Synthesis: Any Gene in Any Vector
- Vector-based siRNA and miRNA, Ready for Transfection
- Gene Mutant Library, Variants up to 10^11
- Plasmid Preparation
- GenScript Custom Peptide Services for MLF2
- Novus Biologicals Antibodies for MLF2
- Novus Biologicals proteins and lysates for MLF2
- Novus Biologicals
- Novus Biologicals Tissue Microarrays
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
- ViGene Biosciences adenoviral particle packaged cDNA for MLF2 gene
- ViGene Biosciences lentiviral particle packaged cDNA for MLF2 gene
- ViGene Biosciences lentiviral particle packaged cDNA for MLF2 gene
- ViGene Biosciences ready-to-package AAV shRNAs for MLF2 gene
- ViGene Biosciences ready-to-package AAV shRNAs for MLF2 gene
- ViGene Biosciences ready-to-package AAV shRNAs for MLF2 gene
- Search ViGene Biosciences for MLF2
- Search ViGene Biosciences for MLF2
- Santa Cruz Biotechnology (SCBT) Antibodies for MLF2
- Search Santa Cruz Biotechnology (SCBT) for MLF2 siRNA/shRNA
- Santa Cruz Biotechnology (SCBT) CRISPR for MLF2
Sources for MLF2 Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) I2D
- (22) IntAct
- (23) Novoseek
- (24) PharmGKB
- (25) DrugBank
- (26) HMDB
- (27) UniGene
- (28) AceView
- (29) RNAdb
- (30) ASD
- (31) ECgene
- (32) GeneAnnot
- (33) SAGE
- (34) SOURCE
- (35) HomoloGene
- (36) PanEnsembl
- (37) euGenes
- (38) SGD
- (39) FlyBase
- (40) WormBase
- (41) Pseudogene
- (42) DGV
- (43) dbSNP
- (44) HapMap
- (45) GenAtlas
- (46) GeneTests
- (47) HGMD
- (48) GAD
- (49) LSDB
- (50) BGMUT
- (51) HuGE
- (52) eBioscience
- (53) Atlas
- (54) Cell Signaling Technology
- (55) GenBank
- (56) H-invDB
- (57) HORDE
- (58) HUGE
- (59) IMGT
- (60) Leiden
- (61) MILLIPORE
- (62) miRBase
- (63) DME
- (64) Nature
- (65) NCBI
- (66) OriGene
- (67) PubMed
- (68) R&D Systems
- (69) Salk
- (70) TGDB
- (71) Tufts
- (72) YEDA
- (73) CROW21
- (74) Tocris
- (75) Abcam
- (76) Novus
- (77) ProSpec
- (78) Sino Biological
- (79) GenScript
- (80) Qiagen
- (81) Cloud-Clone Corp.
- (82) Enzo Life Sciences
- (83) OCA
- (84) Proteopedia
- (85) MOPED
- (86) SPIRE
- (87) neXtProt
- (88) Reactome
- (89) GeneGo (Thomson Reuters)
- (90) fRNAdb
- (91) DISEASES
- (92) SIMAP
- (93) GenomeRNAi
- (94) LifeMap
- (95) miRTarBase
- (96) MalaCards
- (97) Invitrogen
- (98) BitterDB
- (99) Vector BioLabs
- (100) ESI-BIO
- (101) RefSeq
- (102) BioSystems
- (103) MaxQB
- (104) IUPHAR
- (105) BioGPS
- (106) Illumina
- (107) COMPARTMENTS
- (108) HOMER
- (109) PaxDb
- (110) ApexBio
- (111) Addgene
- (112) Advanced Cell Diagnostics
- (113) antibodies-online
- (114) CYP
- (115) NONCODE
- (116) SwitchGear Genomics
- (117) TreeFam
- (118) PathCards
- (119) GeneReviews
- (120) GeneTex
- (121) Taconic Biosciences
- (122) GTEx
- (123) ProteomicsDB
- (124) SCBT
- (125) DGIdb
- (126) ClinicalTrials
- (127) FDA Approved Drugs
- (128) RVIS
- (129) SIGNOR
- (130) diseasecard
- (131) NIH Rare Diseases
- (132) Orphanet
- (133) UMLS
- (134) GTR
- (135) Disease Ontology
- (136) Genetics Home Reference
- (137) MeSH
- (138) MedlinePlus
- (139) CDC
- (140) NINDS
- (141) NCBI Bookshelf
- (142) ClinVar
- (143) Gene Damage Index
- (144) ViGene Biosciences
- (145) HPO
- (146) UDN
- (147) VISTA
- (148) FANTOM5
- (149) ENCODE
- (150) ProSci
- (151) Horizon