Aliases for MLF2 Gene
Aliases for MLF2 Gene
External Ids for MLF2 Gene
- HGNC: 7126
- Entrez Gene: 8079
- Ensembl: ENSG00000089693
- OMIM: 601401
- UniProtKB: Q15773
Previous GeneCards Identifiers for MLF2 Gene
- GC12P006734
- GC12P006859
- GC12M006553
- GC12M006857
Summaries for MLF2 Gene
GeneCards Summary for MLF2 Gene
MLF2 (Myeloid Leukemia Factor 2) is a Protein Coding gene. Diseases associated with MLF2 include Myeloid Leukemia and Leukemia. An important paralog of this gene is MLF1.
No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MLF2 Gene
Genomics for MLF2 Gene
Regulatory Elements for MLF2 Gene
Enhancers for MLF2 Gene
- Elite enhancer and/or Elite enhancer-gene association
Download GeneHancer data dump
Enhancers around MLF2 on UCSC Golden Path with GeneCards custom track
- Transcription factor binding sites by QIAGEN in the MLF2 gene promoter:
Regulatory Element Products
Genomic Location for MLF2 Gene
- Chromosome:
- 12
- Start:
- 6,747,992 bp from pter
- End:
- 6,767,475 bp from pter
- Size:
- 19,484 bases
- Orientation:
- Minus strand
Genomic View for MLF2 Gene
Genes around MLF2 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 12p13.31 by Ensembl
- 12p13.31 by Entrez Gene
- 12p13.31 by HGNC
MLF2 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for MLF2 Gene
Proteins for MLF2 Gene
-
Protein details for MLF2 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q15773-MLF2_HUMAN
- Recommended name:
- Myeloid leukemia factor 2
- Protein Accession:
- Q15773
Protein attributes for MLF2 Gene
- Size:
- 248 amino acids
- Molecular mass:
- 28147 Da
- Quaternary structure:
- No Data Available
Protein Expression for MLF2 Gene
Post-translational modifications for MLF2 Gene
Other Protein References for MLF2 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
-
Custom Antibody ServicesOriGene Antibodies for MLF2
- TA339009
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- TA504845EM
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- TA504845BM
- TA504845AM
- TA504844JM
- TA504844HM
- TA504844GM
- TA504844FM
- Novus Biologicals Antibodies for MLF2
- Invitrogen Antibodies for MLF2
- Search GeneTex for Antibodies for MLF2
-
Santa Cruz Biotechnology (SCBT) Antibodies for MLF2
Protein Products
-
OriGene Purified Proteins for MLF2
- Search Origene for MassSpec and Protein Over-expression Lysates for MLF2
- Origene Custom Protein Services for MLF2
- Search GeneTex for Proteins for MLF2
No data available for DME Specific Peptides for MLF2 Gene
Domains & Families for MLF2 Gene
Protein Domains for MLF2 Gene
- InterPro:
- ProtoNet:
Suggested Antigen Peptide Sequences for MLF2 Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
Q15773- Family:
-
- Belongs to the MLF family.
No data available for Gene Families for MLF2 Gene
Function for MLF2 Gene
Molecular function for MLF2 Gene
- GENATLAS Biochemistry:
- myelodysplasia/myeloid leukemia factor 2,cytoplasmic,ubiquitously expressed currently no evidence for the involvement of MLF2 in hematologic malignancies
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005515 | protein binding | IPI | 23414517 |
Phenotypes for MLF2 Gene
- GenomeRNAi human phenotypes for MLF2:
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
- Cyagen custom Knockout/knockin (KOKI) mouse models for MLF2
-
-
ViGene Biosciences lentiviral particle packaged cDNA for MLF2 gene
-
ViGene Biosciences ready-to-package AAV shRNAs for MLF2 gene
- Search ViGene Biosciences for MLF2
CRISPR Products
-
OriGene CRISPR knockouts for MLF2
-
Applied Biological Materials CRISPR for MLF2
-
Santa Cruz Biotechnology (SCBT) CRISPR for MLF2
- GenScript: Design CRISPR guide RNA sequences for MLF2
miRNA for MLF2 Gene
- miRTarBase miRNAs that target MLF2
-
- hsa-mir-744-5p (MIRT037535)
- hsa-mir-296-3p (MIRT038370)
- hsa-mir-92a-3p (MIRT049518)
- hsa-mir-16-5p (MIRT051088)
- hsa-mir-3679-3p (MIRT655710)
- hsa-mir-6826-3p (MIRT655711)
- hsa-mir-4662a-5p (MIRT655712)
- hsa-mir-6756-3p (MIRT655713)
- hsa-mir-3127-3p (MIRT655714)
- hsa-mir-6507-3p (MIRT655715)
- hsa-mir-4282 (MIRT655716)
miRNA Products
- Search ViGene Biosciences for MLF2
Inhibitory RNA Products
- Origene RNAi, siRNA, and shRNA products in human, mouse, rat for MLF2
- Browse OriGene Inhibitory RNA Products For MLF2
-
ViGene Biosciences ready-to-package AAV shRNAs for MLF2 gene
Clone Products
- Sino Biological Human cDNA Clone for MLF2
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
- VectorBuilder custom plasmid, inducible vectors for MLF2
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for MLF2
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
Cell Line Products
-
Horizon Cell Lines for MLF2
-
ViGene Biosciences adenoviral particle packaged cDNA for MLF2 gene
-
ViGene Biosciences lentiviral particle packaged cDNA for MLF2 gene
-
ViGene Biosciences ready-to-package AAV shRNAs for MLF2 gene
No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for MLF2 Gene
Localization for MLF2 Gene
Subcellular locations from UniProtKB/Swiss-Prot for MLF2 Gene
- Cytoplasm. Nucleus.
| Compartment | Confidence |
|---|---|
| nucleus | 5 |
| cytosol | 4 |
| plasma membrane | 2 |
| extracellular | 1 |
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005634 | nucleus | IEA | -- |
| GO:0005737 | cytoplasm | IEA | -- |
| GO:0016020 | membrane | IDA | 19946888 |
Pathways & Interactions for MLF2 Gene
No Data Available
Interacting Proteins for MLF2 Gene
Selected Interacting proteins:
Q15773-MLF2_HUMAN
ENSP00000203630
for MLF2 Gene via
IID
STRING
UniProtKB
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0006952 | defense response | IMP | 8661158 |
No data available for Pathways by source and SIGNOR curated interactions for MLF2 Gene
Transcripts for MLF2 Gene
mRNA/cDNA for MLF2 Gene
- (1) REFSEQ mRNAs :
- (10) Additional mRNA sequences :
- (725) Selected AceView cDNA sequences:
- (11) Ensembl transcripts including schematic representations, and UCSC links where relevant :
Unigene Clusters for MLF2 Gene
CRISPR Products
-
OriGene CRISPR knockouts for MLF2
-
Applied Biological Materials CRISPR for MLF2
-
Santa Cruz Biotechnology (SCBT) CRISPR for MLF2
- GenScript: Design CRISPR guide RNA sequences for MLF2
miRNA Products
- Search ViGene Biosciences for MLF2
Inhibitory RNA Products
- Origene RNAi, siRNA, and shRNA products in human, mouse, rat for MLF2
- Browse OriGene Inhibitory RNA Products For MLF2
-
ViGene Biosciences ready-to-package AAV shRNAs for MLF2 gene
Clone Products
- Sino Biological Human cDNA Clone for MLF2
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
- VectorBuilder custom plasmid, inducible vectors for MLF2
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for MLF2
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
| ExUns: | 1a | · | 1b | · | 1c | · | 1d | ^ | 2a | · | 2b | ^ | 3a | · | 3b | ^ | 4 | ^ | 5 | ^ | 6a | · | 6b | ^ | 7a | · | 7b | ^ | 8a | · | 8b | ^ | 9a | · | 9b |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | - | - | - | ||||||||||||||||||||||||||||||||
| SP2: | - | ||||||||||||||||||||||||||||||||||
| SP3: | - | - | - | - | - | - | - | ||||||||||||||||||||||||||||
| SP4: | - | - | - | - | - | - | - | ||||||||||||||||||||||||||||
| SP5: | |||||||||||||||||||||||||||||||||||
| SP6: | - |
Expression for MLF2 Gene
This gene is overexpressed in Neutrophil (33.9), Platelet (9.8), and Retina (6.5).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for MLF2 Gene
NURSA nuclear receptor signaling pathways regulating expression of MLF2 Gene:
MLF2SOURCE GeneReport for Unigene cluster for MLF2 Gene:
Hs.524214mRNA Expression by UniProt/SwissProt for MLF2 Gene:
Q15773-MLF2_HUMAN
Tissue specificity:
Ubiquitously expressed.
Evidence on tissue expression from TISSUES for MLF2 Gene
- Nervous system(4.9)
- Lung(4.7)
- Liver(4.5)
- Skin(2.9)
- Muscle(2.6)
- Eye(2.5)
- Kidney(2.3)
- Intestine(2.2)
Primer Products
-
OriGene qPCR primer pairs for MLF2
-
OriGene qPCR primer pairs and template standards for MLF2
No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for MLF2 Gene
Orthologs for MLF2 Gene
This gene was present in the common ancestor of animals.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| chimpanzee (Pan troglodytes) |
Mammalia | MLF2 34 35 |
|
||
| dog (Canis familiaris) |
Mammalia | MLF2 34 35 |
|
||
| oppossum (Monodelphis domestica) |
Mammalia | MLF2 35 |
|
OneToOne | |
| platypus (Ornithorhynchus anatinus) |
Mammalia | MLF2 35 |
|
OneToOne | |
| cow (Bos Taurus) |
Mammalia | MLF2 34 35 |
|
||
| rat (Rattus norvegicus) |
Mammalia | Mlf2 34 |
|
||
| mouse (Mus musculus) |
Mammalia | Mlf2 34 16 35 |
|
||
| chicken (Gallus gallus) |
Aves | MLF2 34 35 |
|
||
| lizard (Anolis carolinensis) |
Reptilia | MLF2 35 |
|
OneToOne | |
| tropical clawed frog (Silurana tropicalis) |
Amphibia | mlf2 34 |
|
||
| Str.1911 34 |
|
||||
| zebrafish (Danio rerio) |
Actinopterygii | mlf2 34 35 |
|
||
| wufj39f09 34 |
|
||||
| rainbow trout (Oncorhynchus mykiss) |
Actinopterygii | Omy.10102 34 |
|
||
| fruit fly (Drosophila melanogaster) |
Insecta | Mlf 35 |
|
OneToMany |
- Species where no ortholog for MLF2 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea squirt (Ciona intestinalis)
- sea squirt (Ciona savignyi)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- wheat (Triticum aestivum)
- worm (Caenorhabditis elegans)
Paralogs for MLF2 Gene
(2) SIMAP similar genes for MLF2 Gene using alignment to 5 proteins:
Pseudogenes.org Pseudogenes for MLF2 Gene
Variants for MLF2 Gene
| SNP ID | Clin | Chr 12 pos | Sequence Context | AA Info | Type |
|---|---|---|---|---|---|
| VAR_036429 | A colorectal cancer sample | ||||
| rs1000489870 | -- | 6,751,250(+) | TCTGG(C/G)TCTGT | intron-variant | |
| rs1000602339 | -- | 6,754,383(+) | GCTTC(A/T)CACGT | upstream-variant-2KB | |
| rs1000866966 | -- | 6,754,814(+) | TTTGG(G/T)AGGCT | upstream-variant-2KB | |
| rs1001059298 | -- | 6,754,045(+) | AGTTA(A/G)CCTGG | upstream-variant-2KB |
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| esv2761725 | CNV | gain | 21179565 |
| esv3580394 | CNV | gain | 25503493 |
| nsv557257 | CNV | loss | 21841781 |
| nsv832322 | CNV | loss | 17160897 |
| nsv832323 | CNV | loss | 17160897 |
Residual Variation Intolerance Score:
48.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
0.68;
14.54% of all genes are more intolerant (likely to be disease-causing)
Relevant External Links for MLF2 Gene
- SNPedia medical, phenotypic, and genealogical associations of SNPs for
- MLF2
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MLF2 Gene
Disorders for MLF2 Gene
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| myeloid leukemia |
|
|
| leukemia |
|
|
Search MLF2 in MalaCards
View complete list of genes associated with diseases
Relevant External Links for MLF2
No data available for UniProtKB/Swiss-Prot and Genatlas for MLF2 Gene
Publications for MLF2 Gene
- cDNA cloning, tissue distribution, and chromosomal localization of myelodysplasia/myeloid leukemia factor 2 (MLF2). (PMID: 8661158) Kuefer M.U. … Morris S.W. (Genomics 1996) 2 3 4 64
- Use of expression data and the CGEMS genome-wide breast cancer association study to identify genes that may modify risk in BRCA1/2 mutation carriers. (PMID: 18095154) Walker L.C. … Spurdle A.B. (Breast Cancer Res. Treat. 2008) 3 46 64
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
- Proteomic analysis and identification of cellular interactors of the giant ubiquitin ligase HERC2. (PMID: 25476789) Galligan J.T. … Howley P.M. (J. Proteome Res. 2015) 3 64
- A human interactome in three quantitative dimensions organized by stoichiometries and abundances. (PMID: 26496610) Hein M.Y. … Mann M. (Cell 2015) 3 64
Products for MLF2 Gene
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- Custom Antibody ServicesOriGene Antibodies for MLF2
- TA339009
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- Browse OriGene ELISA Kits
- Custom Assay Services
- OriGene Purified Proteins for MLF2
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- OriGene qPCR primer pairs and template standards for MLF2
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- GenScript: Design CRISPR guide RNA sequences for MLF2
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- Novus Biologicals Antibodies for MLF2
- Novus Biologicals proteins and lysates for MLF2
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- Browse Antibodies at Cloud-Clone Corp.
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- Cloud-Clone Corp. disease models service
- Browse cDNA clones at Cloud-Clone Corp.
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- Cloud-Clone Corp. primary cells service
- Invitrogen Antibodies for MLF2
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
- Search GeneTex for Antibodies for MLF2
- Search GeneTex for Proteins for MLF2
- ViGene Biosciences adenoviral particle packaged cDNA for MLF2 gene
- ViGene Biosciences lentiviral particle packaged cDNA for MLF2 gene
- ViGene Biosciences ready-to-package AAV shRNAs for MLF2 gene
- Search ViGene Biosciences for MLF2
- Santa Cruz Biotechnology (SCBT) Antibodies for MLF2
- Search Santa Cruz Biotechnology (SCBT) for MLF2 siRNA/shRNA
- Santa Cruz Biotechnology (SCBT) CRISPR for MLF2
- Horizon Cell Lines for MLF2
- Cyagen custom Knockout/knockin (KOKI) mouse models for MLF2
- VectorBuilder custom plasmid, inducible vectors for MLF2
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for MLF2
- VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
Sources for MLF2 Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) IntAct
- (22) Novoseek
- (23) PharmGKB
- (24) DrugBank
- (25) HMDB
- (26) UniGene
- (27) AceView
- (28) RNAdb
- (29) ASD
- (30) ECgene
- (31) GeneAnnot
- (32) CGAP SAGE
- (33) SOURCE
- (34) HomoloGene
- (35) PanEnsembl
- (36) euGenes
- (37) SGD
- (38) FlyBase
- (39) WormBase
- (40) Pseudogene
- (41) DGV
- (42) dbSNP
- (43) GenAtlas
- (44) GeneTests
- (45) HGMD
- (46) GAD
- (47) LSDB
- (48) BGMUT
- (49) HuGE
- (50) eBioscience
- (51) Atlas
- (52) Cell Signaling Technology
- (53) GenBank
- (54) H-invDB
- (55) HORDE
- (56) HUGE
- (57) IMGT
- (58) Leiden
- (59) MILLIPORE
- (60) miRBase
- (61) DME
- (62) NCBI
- (63) OriGene
- (64) PubMed
- (65) R&D Systems
- (66) TGDB
- (67) Tocris
- (68) Abcam
- (69) Novus Biologicals
- (70) ProSpec
- (71) Sino Biological
- (72) GenScript
- (73) Qiagen
- (74) Cloud-Clone Corp.
- (75) Enzo Life Sciences
- (76) OCA
- (77) Proteopedia
- (78) MOPED
- (79) SPIRE
- (80) neXtProt
- (81) Reactome
- (82) GeneGo (Thomson Reuters)
- (83) fRNAdb
- (84) DISEASES
- (85) SIMAP
- (86) GenomeRNAi
- (87) LifeMap
- (88) miRTarBase
- (89) MalaCards
- (90) Invitrogen
- (91) BitterDB
- (92) Vector BioLabs
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