MLF2 Gene
protein-coding GIFtS: 51
GCID: GC12M006857
|
|
myeloid leukemia factor 2
| |
Aliases
for MLF2 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Myeloid Leukemia Factor 21 2 | | NTN41 2 | | Myelodysplasia-Myeloid Leukemia Factor 22 3 |
Export aliases for MLF2 gene to outside databasesPrevious GC identifers: GC12P006734 GC12P006859 GC12M006553 GC12M006727 |
Summaries
for MLF2 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
-- |
Genomic Views
for MLF2 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000012.11 NC_018923.1 NT_009759.16
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the MLF2 gene promoter:
AP-2alpha isoform 3 AP-2alpha isoform 4 AP-2alpha isoform 2 AP-2alpha AP-2alphaA
Other transcription factors
Search SABiosciences Chromatin IP Primers for MLF2
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat MLF2 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 12p13 Ensembl cytogenetic band: 12p13.31 HGNC cytogenetic band: 12p13MLF2 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 12 GeneLoc Exon Structure GeneLoc location for GC12M006857: view genomic region
(about GC identifiers)
Start:
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6,857,158 bp from pter |
End:
|
6,876,641 bp from pter |
Size:
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19,484 bases |
Orientation:
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minus strand |
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Proteins
for MLF2 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: MLF2_HUMAN, Q15773 (See
protein sequence)Recommended Name: Myeloid leukemia factor 2 Size: 248 amino acids; 28147 Da
Subcellular location: Cytoplasm (By similarity). Nucleus (By similarity)Explore the universe of human proteins at neXtProt for MLF2: NX_Q15773
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q15773
MLF2 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_005430.1
ENSEMBL proteins: ENSP00000203630 ENSP00000438671 ENSP00000446317 ENSP00000439789 ENSP00000443829 ENSP00000442444 ENSP00000403941
Human Recombinant Protein Products:
Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view): About this table
MLF2 for ontologies About GeneDecksing
MLF2 Antibody Products:
Assay Products for MLF2: |
Protein
Domains /
Families
for MLF2 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
MLF2 for domains About GeneDecksing
1 InterPro domain/family:Graphical View of Domain Structure for InterPro Entry Q15773ProtoNet protein and cluster: Q15773 UniProtKB/Swiss-Prot: MLF2_HUMAN, Q15773Similarity: Belongs to the MLF family |
Function
for MLF2 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
Genatlas biochemistry entry for MLF2:myelodysplasia/myeloid leukemia factor 2,cytoplasmic,ubiquitously expressed currently no evidence for the involvementof MLF2 in hematologic malignancies
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for MLF2 (see all 4)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for MLF2 (see all 2)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: MLF2 (NM_005439) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for MLF2 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MLF2 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MLF2 |
1 GenomeRNAi human phenotype for MLF2:
|
Pathways & Interactions
for MLF2 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for MLF2
STRING Interaction
Network Preview (showing 5 interactants - click image to see 10)
5/13 Interacting proteins for MLF2 (Q157732, 3 ENSP000002036304) via UniProtKB, MINT, STRING, and/or I2D (see all 13)About this table
Gene Ontology (GO): 1 biological process term (GO ID links to tree view): About this table
MLF2 for ontologies About GeneDecksing
|
Drugs & Compounds
for MLF2 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for MLF2
Search CenterWatch for drugs/clinical trials and news about MLF2
|
Transcripts
for MLF2 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for MLF2 gene: NM_005439.2 Unigene Cluster for MLF2: Myeloid leukemia factor 2 Hs.524214 [show with all ESTs]Unigene Representative Sequence: BM91931111 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000203630(uc001qqp.3) ENST00000541305 ENST00000542154 ENST00000539187(uc009zey.1)
ENST00000537126 ENST00000541346 ENST00000540710 ENST00000564181 ENST00000536207
ENST00000536249 ENST00000435120(uc010sfi.2)
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for MLF2 (see all 4)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for MLF2 (see all 2)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: MLF2 (NM_005439) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for MLF2 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MLF2 |
Additional cDNA sequence: AF070539.1 AK289869.1 AK313998.1 BC000898.2 BC002340.2 BT019393.1 BT019432.1 CR541700.1 NR_026581.1 U57342.1 24/28 DOTS entries (see all 28): DT.446208 DT.97764865 DT.100808935 DT.100885810 DT.100885826 DT.92470076 DT.40106225 DT.100758921 DT.121122958 DT.100765729 DT.100804081 DT.100885813 DT.121122841 DT.40132214 DT.92470108 DT.95187711 DT.100804491 DT.100885812 DT.100885815 DT.100885819 DT.121122840 DT.86835785 DT.86838340 DT.92470075 24/725 AceView cDNA sequences (see all 725): BM761076 AL540956 BQ934610 BE409250 BG825370 AW628075 CR622171 BM924609 BF969681 BF115261 R34707 BM803897 CD369650 CD365099 BM762355 AA427592 BU193266 BM743171 AW675576 CA312845 AI626110 BE857208 BQ946079 BU196862
GeneLoc Exon Structure
5/6 Alternative Splicing Database (ASD) splice patterns (SP) for MLF2 (see all 6) About this scheme
| ExUns: | 1a | · | 1b | · | 1c | · | 1d | ^ | 2a | · | 2b | ^ | 3a | · | 3b | ^ | 4 | ^ | 5 | ^ | 6a | · | 6b | ^ | 7a | · | 7b | ^ | 8a | · | 8b | ^ | 9a | · | 9b |
|---|
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| SP1: | | | | | | | | | - | | | | | | | | | | | | | | - | | | | | | | | - | | | | | | |
| SP2: | | | | | | | | | - | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP3: | | | | | | | | | - | | | | | | | | | | - | | - | | - | | - | | - | | | | - | | | | | | |
| SP4: | | | | | | | | | - | | | | | | - | | - | | - | | - | | - | | - | | | | | | | | | | | | |
| SP5: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
ECgene alternative splicing isoforms for MLF2
|
Expression
for MLF2 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| MLF2 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: CATTGAAGGG
About this image
See MLF2 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for MLF2
SOURCE GeneReport for Unigene cluster: Hs.524214
UniProtKB/Swiss-Prot: MLF2_HUMAN, Q15773Tissue specificity: Ubiquitously expressed
SABiosciences Custom PCR Arrays for MLF2
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for MLF2
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse / rat MLF2 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat MLF2 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat MLF2 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MLF2 |
Orthologs
for MLF2 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of animals.
Orthologs for MLF2 gene from 7/21 species (see all 21) About this table
ENSEMBL Gene Tree for MLF2 (if available)
TreeFam Gene Tree for MLF2 (if available) |
Paralogs
for MLF2 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for MLF2 gene
- MLF12
2 SIMAP similar genes for MLF2 using alignment to 5 protein entries: MLF2_HUMAN (see all proteins):MLF1 DKFZp313B1621
MLF2 for paralogs About GeneDecksing
1 Pseudogenes.org Pseudogene for MLF2
PGOHUM00000260417
|
Genomic Variants
for MLF2 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 12 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for MLF2 (6857158 - 6876641 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for MLF2: -- | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing MLF2 |
|
Disorders
/ Diseases
for MLF2 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
MLF2 for disorders About GeneDecksing
OMIM gene information: 601401
OMIM disorders: --
5  diseases for MLF2: About MalaCardsmyeloid leukemia leukemia coccidiosis acute leukemia
breast cancer
Human Genome Epidemiology (HuGE) Navigator: MLF2 (2 documents)
Export disorders for MLF2 gene to outside databases
|
Publications
for MLF2 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for MLF2 gene, integrated from 9 sources (see all 24):
(articles sorted by number of sources associating them with MLF2) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- cDNA cloning, tissue distribution, and chromosomal localization of myelodysplasia/myeloid leukemia factor 2 (MLF2). (PubMed id 8661158)1, 2, 3 Kuefer M.U.... Morris S.W. (1996)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- A high-throughput approach for measuring temporal chan ges in the interactome. (PubMed id 22863883)1 Kristensen A.R....Foster L.J. (2012)
- Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (2011)
- System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation. (PubMed id 21406692)2 Rigbolt K.T....Blagoev B. (2011)
- Mass spectrometric analysis of lysine ubiquitylation r eveals promiscuity at site level. (PubMed id 21139048)1 Danielsen J.M....Nielsen M.L. (2011)
- Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis. (PubMed id 20068231)2 Olsen J.V....Mann M. (2010)
- Network organization of the human autophagy system. (PubMed id 20562859)1 Behrends C....Harper J.W. (2010)
- Large-scale proteomics analysis of the human kinome. (PubMed id 19369195)2 Oppermann F.S.... Daub H. (2009)
- Toward a confocal subcellular atlas of the human proteome. (PubMed id 18029348)1 Barbe L....Andersson-Svahn H. (2008)
|
External Searches for MLF2 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing MLF2 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing MLF2 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing MLF2 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
|
About This Section
| Patent Information for MLF2 gene:
Search GeneIP for patents involving MLF2
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for MLF2 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
| | |  | OriGene Antibodies for MLF2 | | OriGene shRNA RFP for MLF2 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for MLF2 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for MLF2 | | | OriGene Protein Over-expression Lysate for MLF2 | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for MLF2 | | OriGene 3'-UTR Clone for MLF2 | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for MLF2 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for MLF2 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for MLF2 | | OriGene Custom Protein Services for MLF2 | | | OriGene Custom Immunoassay Development | | |
| |
 |
 |
| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat MLF2 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing MLF2 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat MLF2 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat MLF2 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat MLF2 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat MLF2 |
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 | | | MLF2 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MLF2 |
|  |  |  | | | | Search ThermoFisher Antibodies for MLF2 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MLF2 |
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