Home
GeneCards Guide
Suite
- MalaCards
- GeneALaCart
- GeneDecks
- GeneIP
- GeneLoc
Terms of Use
- Terms of Use
- 3rd Party Notice
About Us
- GeneCards Team
- Our Publications
- Citing GeneCards
- Licensing Agreement
- Weizmann Institute
- LifeMap Sciences Inc
User Feedback
GeneCards Plus
- Premium Tools
  
  Learn more

Set Analyses:

VarElect

Advanced Search

MLF2 Gene

protein-coding GIFtS: 55
GCID: GC12M006857

Myeloid Leukemia Factor 2

See related diseases
at

MalaCards

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, ¹⁰fRNAdb, ¹²H-InvDB, ¹³NCBI, ¹⁴NONCODE, and/or ¹⁵RNAdb)
About This Section

TryGeneCards Plus

Aliases
Myeloid Leukemia Factor 2¹ ²
Myelodysplasia-Myeloid Leukemia Factor 2² ³
NTN4²

External Ids:	HGNC: 7126¹	Entrez Gene: 8079²	Ensembl: ENSG00000089693⁷	OMIM: 601401⁵	UniProtKB: Q15773³

Export aliases for MLF2 gene to outside databases

Previous GC identifers: GC12P006734 GC12P006859 GC12M006553 GC12M006727

(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

TryGeneCards Plus

GeneCards Summary for MLF2 Gene:

MLF2 (myeloid leukemia factor 2) is a protein-coding gene. Diseases associated with MLF2 include coccidiosis, and myeloid leukemia. An important paralog of this gene is MLF1.

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
About This Section

TryGeneCards Plus

RefSeq DNA sequence:

NC_000012.12 NC_018923.2 NT_009759.17

Regulatory elements:

Regulatory transcription factor binding sites in the MLF2 gene promoter:
AP-2alpha isoform 3 AP-2alpha isoform 4 AP-2alpha isoform 2 AP-2alpha AP-2alphaA
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: MLF2 promoter sequence

Search Chromatin IP Primers for MLF2

Epigenetics:

DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat MLF2

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 12p13 Ensembl cytogenetic band: 12p13.31 HGNC cytogenetic band: 12p13

MLF2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
MLF2 gene location

GeneLoc information about chromosome 12 GeneLoc Exon Structure

GeneLoc location for GC12M006857: view genomic region (about GC identifiers)

Start:	6,857,158 bp from pter	End:	6,876,641 bp from pter
Size:	19,484 bases	Orientation:	minus strand

(According to ¹UniProtKB, HORDE, ²neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

TryGeneCards Plus

UniProtKB/Swiss-Prot: MLF2_HUMAN, Q15773 (See protein sequence)

Recommended Name: Myeloid leukemia factor 2

Size: 248 amino acids; 28147 Da

Explore the universe of human proteins at neXtProt for MLF2: NX_Q15773

Explore proteomics data for MLF2 at MOPED

Post-translational modifications:

Modification sites at neXtProt

Modification sites at PhosphoSitePlus

See MLF2 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

REFSEQ proteins: NP_005430.1

ENSEMBL proteins:

ENSP00000203630 ENSP00000438671 ENSP00000446317 ENSP00000439789 ENSP00000443829

ENSP00000442444 ENSP00000403941

MLF2 Human Recombinant Protein Products:

	Browse Purified and Recombinant Proteins at EMD Millipore
	Browse R&D Systems for human recombinant proteins
	Browse recombinant and purified proteins available from Enzo Life Sciences
	Browse OriGene full length recombinant human proteins expressed in human HEK293 cells OriGene Protein Over-expression Lysate for MLF2 OriGene Custom MassSpec OriGene Custom Protein Services for MLF2
	GenScript Custom Purified and Recombinant Proteins Services for MLF2
	Novus Biologicals MLF2 Protein Novus Biologicals MLF2 Lysates
	Browse Sino Biological Recombinant Proteins Browse Sino Biological Cell Lysates
	Browse ProSpec Recombinant Proteins
	Cloud-Clone Corp. Proteins for MLF2

MLF2 Antibody Products:

	Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
	Browse R&D Systems for Antibodies
	OriGene Antibodies for MLF2 OriGene Custom Antibody Services for MLF2
	Novus Biologicals MLF2 Antibodies
	Abcam antibodies for MLF2
	Cloud-Clone Corp. Antibodies for MLF2
	Search ThermoFisher Antibodies for MLF2
	LSBio Antibodies in human, mouse, rat for MLF2

MLF2 Assay Products:

	Browse Kits and Assays available from EMD Millipore
	OriGene Custom Assay Services for MLF2
	Browse R&D Systems for biochemical assays
	GenScript Custom Assay Services for MLF2
	Browse Enzo Life Sciences for kits & assays
	Cloud-Clone Corp. ELISAs for MLF2 Cloud-Clone Corp. CLIAs for MLF2

(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

TryGeneCards Plus

1 InterPro protein domain:

IPR019376 Myeloid_leukemia_factor

Graphical View of Domain Structure for InterPro Entry Q15773

ProtoNet protein and cluster: Q15773

UniProtKB/Swiss-Prot: MLF2_HUMAN, Q15773

Similarity: Belongs to the MLF family

MLF2 for domains About GeneDecksing

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
About This Section

TryGeneCards Plus

Molecular Function:

Genatlas biochemistry entry for MLF2:

myelodysplasia/myeloid leukemia factor 2,cytoplasmic,ubiquitously expressed currently no evidence for the

involvement of MLF2 in hematologic malignancies

Phenotypes:
1 GenomeRNAi human phenotype for MLF2:

Synthetic lethal with Ras

Animal Models:

inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for MLF2

inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for MLF2

genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for MLF2

genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for MLF2

miRNA Products:		miRTarBase miRNAs that target MLF2: hsa-mir-296-3p (MIRT038370), hsa-mir-92a-3p (MIRT049518), hsa-mir-744-5p (MIRT037535), hsa-mir-16-5p (MIRT051088)

		Block miRNA regulation of human, mouse, rat MLF2 using miScript Target Protectors
		7 qRT-PCR Assays for microRNAs that regulate MLF2:
		hsa-miR-587 hsa-miR-125a-5p hsa-miR-125b hsa-miR-3613-3p hsa-miR-889 hsa-miR-551b* hsa-miR-4319
		SwitchGear 3'UTR luciferase reporter plasmid: MLF2 3' UTR sequence

Inhib. RNA Products:		OriGene RNAi products in human, mouse, rat for MLF2
		Predesigned siRNA for gene silencing in human, mouse, rat MLF2

Gene Editing
Products:

DNA2.0 Custom Protein Engineering Service for MLF2

Clone Products:		OriGene clones in human, mouse for MLF2 (see all 9) OriGene ORF clones in mouse, rat for MLF2 OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector: MLF2 (NM_005439)
		Sino Biological Human cDNA Clone for MLF2
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for MLF2
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MLF2

Cell Line Products:		GenScript Custom overexpressing Cell Line Services for MLF2
		Browse ESI BIO Cell Lines and PureStem Progenitors for MLF2

In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MLF2

(According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
About This Section

TryGeneCards Plus

Subcellular locations from UniProtKB/Swiss-Prot

MLF2_HUMAN, Q15773: Cytoplasm (By similarity). Nucleus (By similarity)

Subcellular locations from COMPARTMENTS:

Compartment	Confidence
cytosol	3
nucleus	2
extracellular	1
plasma membrane	1

About this image

Gene Ontology (GO): 2 cellular component terms: About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005634	nucleus	IEA	--
GO:0005737	cytoplasm	IEA	--

MLF2 for ontologies About GeneDecksing

(SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
About This Section

TryGeneCards Plus

Custom Pathway & Disease-focused RT² Profiler PCR Arrays for MLF2
Interactions:

Search GeneGlobe Interaction Network for MLF2

STRING Interaction Network Preview (showing 5 interactants - click image to see 14)

Selected Interacting proteins for MLF2 (Q15773^{2, 3} ENSP00000203630⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 17)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
ABCD3	P28288³, ENSP00000359233⁴	I2D: score=2 STRING: ENSP00000359233
AIFM1	O95831³, ENSP00000287295⁴	I2D: score=2 STRING: ENSP00000287295
BAG2	O95816³, ENSP00000359727⁴	I2D: score=2 STRING: ENSP00000359727
CIAO1	O76071³, ENSP00000418287⁴	I2D: score=2 STRING: ENSP00000418287
MMS19	Q96T76³, ENSP00000359818⁴	I2D: score=2 STRING: ENSP00000359818

About this table

Gene Ontology (GO): 1 biological process term: About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0006952	defense response	IMP	8661158

MLF2 for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
About This Section

TryGeneCards Plus

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse compounds at ApexBio

Browse Tocris compounds for MLF2

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
About This Section

TryGeneCards Plus

REFSEQ mRNAs for MLF2 gene:

NM_005439.2

Unigene Cluster for MLF2:

Myeloid leukemia factor 2

Hs.524214 [show with all ESTs]

Unigene Representative Sequence: BM919311

11 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000203630(uc001qqp.3) ENST00000541305 ENST00000542154 ENST00000539187(uc009zey.1)

ENST00000537126 ENST00000541346 ENST00000540710 ENST00000564181 ENST00000536207

ENST00000536249 ENST00000435120(uc010sfi.2)

miRNA Products:		Block miRNA regulation of human, mouse, rat MLF2 using miScript Target Protectors
		7 qRT-PCR Assays for microRNAs that regulate MLF2:
		hsa-miR-587 hsa-miR-125a-5p hsa-miR-125b hsa-miR-3613-3p hsa-miR-889 hsa-miR-551b* hsa-miR-4319
		SwitchGear 3'UTR luciferase reporter plasmid: MLF2 3' UTR sequence

Inhib. RNA Products:		OriGene RNAi products in human, mouse, rat for MLF2
		Predesigned siRNA for gene silencing in human, mouse, rat MLF2

Clone Products:		OriGene clones in human, mouse for MLF2 (see all 9) OriGene ORF clones in mouse, rat for MLF2 OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector: MLF2 (NM_005439)
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for MLF2
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MLF2

Primer Products:		OriGene qPCR primer pairs and template standards for MLF2 OriGene qSTAR qPCR primer pairs in human, mouse for MLF2
		Pre-validated RT² qPCR Primer Assay in human, mouse / rat MLF2
		QuantiTect SYBR Green Assays in human, mouse, rat MLF2
		QuantiFast Probe-based Assays in human, mouse, rat MLF2

Additional mRNA sequence:

AF070539.1 AK289869.1 AK313998.1 BC000898.2 BC002340.2 BT019393.1 BT019432.1 CR541700.1

NR_026581.1 U57342.1

Selected DOTS entries (see all 28):

DT.446208 DT.97764865 DT.100808935 DT.100885810 DT.100885826 DT.92470076 DT.40106225 DT.100758921

DT.121122958 DT.100765729 DT.100804081 DT.100885813 DT.121122841 DT.40132214 DT.92470108 DT.95187711

DT.100804491 DT.100885812 DT.100885815 DT.100885819 DT.121122840 DT.86835785 DT.86838340 DT.92470075

Selected AceView cDNA sequences (see all 725):

BQ676790 CR594751 BM922110 BM845663 BQ949338 CB112654 BC000898 BE890938

CR612884 BI914764 BQ771948 AI148736 CD172295 AJ710334 AA316108 AI357711

BF594202 CR597712 BP339203 BF771912 AL555971 BM849168 CR590498 BM693920

GeneLoc Exon Structure

Selected Alternative Splicing Database (ASD) splice patterns (SP) for MLF2 (see all 6) About this scheme

ExUns:	1a	·	1b	·	1c	·	1d	^	2a	·	2b	^	3a	·	3b	^	4	^	5	^	6a	·	6b	^	7a	·	7b	^	8a	·	8b	^	9a	·	9b
SP1:									-														-								-
SP2:									-
SP3:									-										-		-		-		-		-				-
SP4:									-						-		-		-		-		-		-
SP5:

ECgene alternative splicing isoforms for MLF2

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE ¹MOPED, ²PaxDb, and ³MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

TryGeneCards Plus

MLF2 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>^2/3
CGAP TAG: CATTGAAGGG

About this image

MLF2 expression in embryonic tissues and stem cells About this table

Data from LifeMap, the Embryonic Development and Stem Cells Database
selected tissues (see all 21) fully expand


Brain (Nervous System) fully expand to see all 4 entries
Cerebral Cortex

Testis (Reproductive System)
Leydig Cells Testis Interstitium

Liver (Hepatobiliary System)
Hepatocytes Liver Lobule

Ovary (Reproductive System)
Oviduct

Trophoblast (Extraembryonic Tissues)
Trophoblast Cells Trophoblast

MLF2 Protein expression data from MOPED¹, PaxDb² and MaxQB³:

About this image

MLF2 Protein Expression

SOURCE GeneReport for Unigene cluster: Hs.524214

UniProtKB/Swiss-Prot: MLF2_HUMAN, Q15773

Tissue specificity: Ubiquitously expressed

Custom PCR Arrays for MLF2

Primer Products:		OriGene qPCR primer pairs and template standards for MLF2 OriGene qSTAR qPCR primer pairs in human, mouse for MLF2
		Pre-validated RT² qPCR Primer Assay in human, mouse / rat MLF2
		QuantiTect SYBR Green Assays in human, mouse, rat MLF2
		QuantiFast Probe-based Assays in human, mouse, rat MLF2

In Situ
Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MLF2

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

TryGeneCards Plus

This gene was present in the common ancestor of animals.

Orthologs for MLF2 gene from Selected species (see all 14) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
mouse (Mus musculus)	Mammalia	Mlf2^{1 , 5}	myeloid leukemia factor 2^{1, 5}	89.47(n)¹ 97.17(a)¹		6 (59.17 cM)⁵ 30853¹ NM_145385.2¹ NP_663360.1¹ 124931388⁵
chicken (Gallus gallus)	Aves	MLF2¹	myeloid leukemia factor 2	77.82(n) 86.36(a)		418284 NM_001030776.2 NP_001025947.1
lizard (Anolis carolinensis)	Reptilia	MLF2⁶	myeloid leukemia factor 2	85(a)	1 ↔ 1	GL343453.1(109015-120074)
African clawed frog (Xenopus laevis)	Amphibia	CD303631.1²	--	71.95(n)		CD303631.1
zebrafish (Danio rerio)	Actinopterygii	wufj39f09²	Transcribed sequence with weak similarity to protein more	78.91(n)		CK138593.1
fruit fly (Drosophila melanogaster)	Insecta	Mlf⁶	Myelodysplasia/myeloid leukemia factor	19(a)	1 → many	2R(11823398-11827578)

ENSEMBL Gene Tree for MLF2 (if available)
TreeFam Gene Tree for MLF2 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

TryGeneCards Plus

Paralogs for MLF2 gene

MLF1²

2 SIMAP similar genes for MLF2 using alignment to 5 protein entries: MLF2_HUMAN (see all proteins):

MLF1 DKFZp313B1621

MLF2 for paralogs About GeneDecksing

1 Pseudogenes.org Pseudogene for MLF2
PGOHUM00000260417

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, ⁴UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
About This Section

TryGeneCards Plus

SNP ID	Valid	Clinical significance	Chr 12 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
VAR_036429⁴		A colorectal cancer sample⁴	--	see VAR_036429	2	F C	mis⁴		0	--	--	--	--
rs11064362^1,2	C,F,H	--	6856696(+)	`TCTAGG/TCTCCT`	2	--	ds500¹		8		NS NA WA	914
rs77899180^1,2	F	--	6856795(+)	`GGTTAT/CCTGAA`	2	--	ds500¹		1		WA	118
rs191728728^1,2		--	6856887(+)	`CCCAAC/TACATC`	2	--	ds500¹		0	--	--	--	--
rs141584575^1,2		--	6856960(+)	`TCACGA/CCCCAG`	2	--	ds500¹		0	--	--	--	--
rs2178695^1,2	C,F,A	--	6857000(+)	`ACCTGG/CCAGTG`	2	--	ds500¹		7		NA WA CSA EA	366
rs184691535^1,2		--	6857074(+)	`GAGACA/GAGGAA`	2	--	ds500¹		0	--	--	--	--
rs189987031^1,2		--	6857141(+)	`AAAAGG/TACAGC`	2	--	ds500¹		0	--	--	--	--
rs193023210^1,2		--	6857195(+)	`AACACC/GTAGTT`	2	--	ut3¹ nc-transcript-variant		0	--	--	--	--
rs1050629^1,2	C,F,H	--	6857289(-)	`GGTTCC/TTAACT`	2	--	ut3¹ nc-transcript-variantese³		15		MN NS EA CSA WA NA	2256

HapMap Linkage Disequilibrium report for MLF2 (6857158 - 6876641 bp)

Structural Variations
Database of Genomic Variants (DGV) 3 variations for MLF2: About this table

Variant ID	Type	Subtype	PubMed ID
nsv898635	CNV	Loss	21882294
nsv832323	CNV	Loss	17160897
nsv832322	CNV	Loss	17160897

Site Specific Mutation Identification with PCR Assays

SeqTarget long-range PCR primers for resequencing MLF2

DNA2.0 Custom Variant and Variant Library Synthesis for MLF2

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

TryGeneCards Plus

OMIM gene information: 601401 OMIM disorders: --

14 diseases for MLF2:
About MalaCards

coccidiosis myeloid leukemia leukemia brain cancer

acute leukemia breast and colorectal cancer tonsillitis malaria

cerebritis colorectal cancer thyroiditis breast cancer

endotheliitis prostatitis

MLF2 for disorders About GeneDecksing

Genetic Association Database (GAD): MLF2
Human Genome Epidemiology (HuGE) Navigator: MLF2 (2 documents)

Export disorders for MLF2 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

TryGeneCards Plus

PubMed articles for MLF2 gene, integrated from 10 sources (see all 30):
(articles sorted by number of sources associating them with MLF2)

Utopia: connect your pdf to the dynamic
world of online information

cDNA cloning, tissue distribution, and chromosomal localization of myelodysplasia/myeloid leukemia factor 2 (MLF2). (PubMed id 8661158)^{1, 2, 3} Kuefer M.U.... Morris S.W. (Genomics 1996)
Use of expression data and the CGEMS genome-wide breast cancer association study to identify genes that may modify risk in BRCA1/2 mutation carriers. (PubMed id 18095154)^{1, 4} Walker L.C....Spurdle A.B. (Breast Cancer Res. Treat. 2008)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S.... Malek J. (Genome Res. 2004)
Interlaboratory reproducibility of large-scale human protein-complex analysis by standardized AP-MS. (PubMed id 23455922)¹ Varjosalo M....Superti-Furga G. (Nat. Methods 2013)
The SOX2-interactome in brain cancer cells identifies the requirement of MSI2 and USP9X for the growth of brain tumor cells. (PubMed id 23667531)¹ Cox J.L....Rizzino A. (PLoS ONE 2013)
The functional interactome landscape of the human histone deacetylase family. (PubMed id 23752268)¹ Joshi P....Cristea I.M. (Mol. Syst. Biol. 2013)
MMS19 assembles iron-sulfur proteins required for DNA metabolism and genomic integrity. (PubMed id 22678362)¹ Stehling O.... Lill R. (Science 2012)
A high-throughput approach for measuring temporal changes in the interactome. (PubMed id 22863883)¹ Kristensen A.R....Foster L.J. (Nat. Methods 2012)
Initial characterization of the human central proteome. (PubMed id 21269460)² Burkard T.R.... Colinge J. (BMC Syst. Biol. 2011)
System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation. (PubMed id 21406692)² Rigbolt K.T....Blagoev B. (Sci. Signal. 2011)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

TryGeneCards Plus

		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

TryGeneCards Plus

Entrez Gene: 8079	HGNC: 7126	AceView: MLF2	Ensembl:ENSG00000089693	euGenes: HUgn8079
ECgene: MLF2	H-InvDB: MLF2

(According to HUGE)
About This Section

TryGeneCards Plus

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
About This Section

TryGeneCards Plus

Name	Description
PharmGKB entry for MLF2	Pharmacogenomics, SNPs, Pathways
ATLAS Chromosomes in Cancer entry for MLF2	Genetics and Cytogenetics in Oncology and Haematology

Intellectual Property for MLF2 gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

About This Section

TryGeneCards Plus

Patent Information for MLF2 gene:
Search GeneIP for patents involving MLF2

GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search

(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
About This Section

TryGeneCards Plus


	EMD Millipore genomic analysis products

	Browse Antibodies		Browse Cell Culture Products
	Browse ELISAs		Browse Flow Cytometry Kits
	Browse Primer Pairs		Browse Enzyme Activity Assays/Reagents
	Browse ELISpot/FluoroSpot Kits/Development Modules		Browse TFB/Immunoprecipitation Assays
	Browse Apoptosis Detection Kits/Reagents		Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents
	Browse DNA Damage/Repair Kits/Reagents		Browse Luminex Assays
	Browse Cell Selection/Detection Kits/Reagents		Browse Secondary Antibodies/Controls/Staining Reagents
	Browse Recombinant/Natural Proteins		Browse Stem Cell Products
	Browse cDNA Clones		Browse Proteome Profiler Antibody Arrays

	OriGene Antibodies for MLF2		OriGene RNAi products in human, mouse, rat for MLF2
	OriGene qPCR primer pairs and template standards for MLF2		OriGene Protein Over-expression Lysate for MLF2
	OriGene Custom Mass Spec		OriGene clones in human, mouse for MLF2
	OriGene qSTAR qPCR primer pairs in human, mouse for MLF2		Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
	OriGene ORF clones in mouse, rat for MLF2		OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
	OriGene Custom Antibody Services for MLF2		OriGene Custom Protein Services for MLF2

	Block miRNA regulation of human, mouse, rat MLF2 using miScript Target Protectors		SeqTarget long-range PCR primers for resequencing MLF2
	DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat MLF2		Predesigned siRNA for gene silencing in human, mouse, rat MLF2
	QuantiFast Probe-based Assays in human, mouse, rat MLF2		QuantiTect SYBR Green Assays in human, mouse, rat MLF2
	Custom PCR Arrays for MLF2		Search Chromatin IP Primers for MLF2
	Pre-validated RT² qPCR Primer Assay in human, mouse / rat MLF2		Search GeneGlobe Interaction Network for MLF2
	Regulatory tfbs in MLF2 promoter

	GenScript Custom Purified and Recombinant Proteins Services for MLF2		GenScript cDNA clones with any tag delivered in your preferred vector for MLF2
	GenScript Custom Assay Services for MLF2		GenScript Custom overexpressing Cell Line Services for MLF2
	CloneReady with Over 120,000 Genes		Gene Synthesis: Any Gene in Any Vector
	Vector-based siRNA and miRNA, Ready for Transfection		Gene Mutant Library, Variants up to 10^11
	Plasmid Preparation		Custom Peptide Services

Search for Antibodies & Assays

Search Tocris compounds for MLF2

	Browse Sino Biological Proteins
	Browse Sino Biological Cell Lysates
	cDNA Clones for MLF2
	4000+ Proteins
	Search Sino Biological for antibodies, proteins & pathways
	Protein Production Services
	Transfection Reagents
	Protein A/G/L resins
	Isotyping reagents

Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

	Novus Tissue Slides
	MLF2 antibodies
	MLF2 proteins
	MLF2 lysates

	Antibodies for MLF2
	See all of Abcam's Antibodies, Kits and Proteins for MLF2
	Custom Antibody / Protein Production Service
	Bulk Purchasing
	Advantages of Rabbit Monoclonal antibodies
	Abcam protocols and scientific support

Browse ProSpec Recombinant Proteins

	Proteins for MLF2
	Antibodies for MLF2
	ELISAs for MLF2
	CLIAs for MLF2

Browse ESI BIO Cell Lines and PureStem Progenitors for MLF2

	Gene Synthesis
	Protein Engineering
	Variant Library Synthesis
	Codon Optimization
	Protein Production and Purification

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MLF2

	SwitchGear 3'UTR luciferase reporter plasmids for MLF2
	SwitchGear Promoter luciferase reporter plasmids for MLF2

Search ThermoFisher Antibodies for MLF2

Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MLF2

	inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for MLF2
	inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for MLF2

LSBio Antibodies in human, mouse, rat for MLF2

Customized transgenic rodents for:

	Humanization
	Biomarker expression
	Off-target effect monitoring
	Translational medicine
	Tissue-specific gene expresssion
	Time-controlled gene expresssion

Browse compounds at ApexBio

GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014

View Random Gene

Category			(GIFtS: )
GIFtS Group

The GeneCards human gene database gene index: 1 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

The GeneCards Human Gene Database

Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

Hot genes Disease genes MLF2 gene at Home site.

Version: 3.12.142 28 July 2014
hostname: 356980-web2.xennexinc.com index build: 126 solr: 1.4

GeneCards Plus

Advanced Search

Export list of displayed genes

MLF2 Gene

Myeloid Leukemia Factor 2

Aliases
for MLF2 gene

Summaries
for MLF2 gene

Genomic Views
for MLF2 gene

Proteins
for MLF2 gene

MLF2 Human Recombinant Protein Products:

MLF2 Antibody Products:

MLF2 Assay Products:

Domains /
Families
for MLF2 gene

Function
for MLF2 gene

Localization
for MLF2 gene

Pathways & Interactions
for MLF2 gene

Drugs & Compounds
for MLF2 gene

Transcripts
for MLF2 gene

Expression
for MLF2 gene

Orthologs
for MLF2 gene

Paralogs
for MLF2 gene

Genomic Variants
for MLF2 gene

Disorders / Diseases
for MLF2 gene

Publications
for MLF2 gene

External Searches for MLF2 gene

Genome Databases showing MLF2 gene

Other Databases showing MLF2 gene

Specialized Databases showing MLF2 gene

Intellectual Property
for MLF2 gene

Products
for MLF2 gene

View Random Gene

GeneCards Plus

Advanced Search

Export list of displayed genes

MLF2 Gene

Myeloid Leukemia Factor 2

Aliasesfor MLF2 gene

Summariesfor MLF2 gene

Genomic Viewsfor MLF2 gene

Proteinsfor MLF2 gene

MLF2 Human Recombinant Protein Products:

MLF2 Antibody Products:

MLF2 Assay Products:

Domains /Familiesfor MLF2 gene

Functionfor MLF2 gene

Localizationfor MLF2 gene

Pathways & Interactionsfor MLF2 gene

Drugs & Compoundsfor MLF2 gene

Transcriptsfor MLF2 gene

Expression for MLF2 gene

Orthologsfor MLF2 gene

Paralogsfor MLF2 gene

Genomic Variantsfor MLF2 gene

Disorders / Diseasesfor MLF2 gene

Publicationsfor MLF2 gene

External Searches for MLF2 gene

Genome Databases showing MLF2 gene

Other Databases showing MLF2 gene

Specialized Databases showing MLF2 gene

Intellectual Propertyfor MLF2 gene

Productsfor MLF2 gene

View Random Gene

Aliases
for MLF2 gene

Summaries
for MLF2 gene

Genomic Views
for MLF2 gene

Proteins
for MLF2 gene

Domains /
Families
for MLF2 gene

Function
for MLF2 gene

Localization
for MLF2 gene

Pathways & Interactions
for MLF2 gene

Drugs & Compounds
for MLF2 gene

Transcripts
for MLF2 gene

Expression
for MLF2 gene

Orthologs
for MLF2 gene

Paralogs
for MLF2 gene

Genomic Variants
for MLF2 gene

Disorders / Diseases
for MLF2 gene

Publications
for MLF2 gene

Intellectual Property
for MLF2 gene

Products
for MLF2 gene