Free for academic non-profit institutions. Other users need a Commercial license

Aliases for MLF2 Gene

Aliases for MLF2 Gene

  • Myeloid Leukemia Factor 2 2 3 5
  • Myelodysplasia-Myeloid Leukemia Factor 2 3 4
  • NTN4 3

External Ids for MLF2 Gene

Previous GeneCards Identifiers for MLF2 Gene

  • GC12P006734
  • GC12P006859
  • GC12M006553
  • GC12M006857

Summaries for MLF2 Gene

GeneCards Summary for MLF2 Gene

MLF2 (Myeloid Leukemia Factor 2) is a Protein Coding gene. Diseases associated with MLF2 include Myeloid Leukemia and Leukemia. An important paralog of this gene is MLF1.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MLF2 Gene

Genomics for MLF2 Gene

Regulatory Elements for MLF2 Gene

Enhancers for MLF2 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH12F006751 0.2 ENCODE 13.1 +14.3 14321 3.0 HDGF PKNOX1 CREB3L1 WRNIP1 ARID4B SIN3A DMAP1 ZNF2 YY1 ZNF416 ENSG00000219410 ENSG00000247853 NOP2 SCARNA12 GDF3 NCAPD2 MLF2 SPSB2 ENSG00000256967 C1RL-AS1
GH12F006735 1.1 Ensembl ENCODE 12.6 +31.6 31628 1.1 CTCF INSM2 ARID4B RAD21 ZNF121 HIC1 ZNF316 SCRT2 ZNF547 SMC3 PTMS MLF2 LAG3 CD4 GPR162 P3H3 ENSG00000219410 ING4 ACRBP CHD4
GH12F006734 0.2 ENCODE 12.6 +32.6 32586 0.2 ZNF362 ZNF692 L3MBTL2 ATF2 MGA MLF2 PTMS LAG3 CD4 GPR162 P3H3 ENSG00000219410 ING4 ACRBP CHD4
GH12F006788 1 FANTOM5 ENCODE 11.3 -23.6 -23602 5.0 HDGF PKNOX1 MLX ARID4B ZNF48 YY1 SLC30A9 ZNF121 SP5 NFYC CD4 LPAR5 GPR162 P3H3 PTPN6 ING4 PTMS MLF2 GNB3 PIANP
GH12F006744 1.2 FANTOM5 Ensembl ENCODE 10.3 +21.7 21693 2.0 BCOR CTCF YY2 ZBTB2 MAX ARID4B REST ZBTB40 TEAD3 POLR2A MLF2 ENSG00000269892 PTPN6 CD4 CHD4 TAPBPL VAMP1 ZNF384 GC12P006747
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around MLF2 on UCSC Golden Path with GeneCards custom track

Promoters for MLF2 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000425840 375 3001 HDGF PKNOX1 ARNT ZFP64 ARID4B SIN3A ZNF2 YY1 ZNF143 ZNF263

Genomic Location for MLF2 Gene

Chromosome:
12
Start:
6,747,992 bp from pter
End:
6,767,475 bp from pter
Size:
19,484 bases
Orientation:
Minus strand

Genomic View for MLF2 Gene

Genes around MLF2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MLF2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MLF2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MLF2 Gene

Proteins for MLF2 Gene

  • Protein details for MLF2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q15773-MLF2_HUMAN
    Recommended name:
    Myeloid leukemia factor 2
    Protein Accession:
    Q15773

    Protein attributes for MLF2 Gene

    Size:
    248 amino acids
    Molecular mass:
    28147 Da
    Quaternary structure:
    No Data Available

neXtProt entry for MLF2 Gene

Post-translational modifications for MLF2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for MLF2 Gene

No data available for DME Specific Peptides for MLF2 Gene

Domains & Families for MLF2 Gene

Protein Domains for MLF2 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for MLF2 Gene

Graphical View of Domain Structure for InterPro Entry

Q15773

UniProtKB/Swiss-Prot:

MLF2_HUMAN :
  • Belongs to the MLF family.
Family:
  • Belongs to the MLF family.
genes like me logo Genes that share domains with MLF2: view

No data available for Gene Families for MLF2 Gene

Function for MLF2 Gene

Molecular function for MLF2 Gene

GENATLAS Biochemistry:
myelodysplasia/myeloid leukemia factor 2,cytoplasmic,ubiquitously expressed currently no evidence for the involvement of MLF2 in hematologic malignancies

Gene Ontology (GO) - Molecular Function for MLF2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 DNA binding IBA --
GO:0005515 protein binding IPI 23414517
genes like me logo Genes that share ontologies with MLF2: view
genes like me logo Genes that share phenotypes with MLF2: view

Animal Model Products

Inhibitory RNA Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for MLF2 Gene

Localization for MLF2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for MLF2 Gene

Cytoplasm. Nucleus.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for MLF2 Gene COMPARTMENTS Subcellular localization image for MLF2 gene
Compartment Confidence
nucleus 5
cytosol 4
plasma membrane 2
extracellular 1

Gene Ontology (GO) - Cellular Components for MLF2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA,IBA --
GO:0005737 cytoplasm IEA --
GO:0016020 membrane IDA 19946888
genes like me logo Genes that share ontologies with MLF2: view

Pathways & Interactions for MLF2 Gene

SuperPathways for MLF2 Gene

No Data Available

Gene Ontology (GO) - Biological Process for MLF2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006355 regulation of transcription, DNA-templated IBA --
GO:0006952 defense response IMP 8661158
genes like me logo Genes that share ontologies with MLF2: view

No data available for Pathways by source and SIGNOR curated interactions for MLF2 Gene

Transcripts for MLF2 Gene

Unigene Clusters for MLF2 Gene

Myeloid leukemia factor 2:
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for MLF2 Gene

ExUns: 1a · 1b · 1c · 1d ^ 2a · 2b ^ 3a · 3b ^ 4 ^ 5 ^ 6a · 6b ^ 7a · 7b ^ 8a · 8b ^ 9a · 9b
SP1: - - -
SP2: -
SP3: - - - - - - -
SP4: - - - - - - -
SP5:
SP6: -

Relevant External Links for MLF2 Gene

GeneLoc Exon Structure for
MLF2
ECgene alternative splicing isoforms for
MLF2

Expression for MLF2 Gene

mRNA expression in normal human tissues for MLF2 Gene

Protein differential expression in normal tissues from HIPED for MLF2 Gene

This gene is overexpressed in Neutrophil (33.9), Platelet (9.8), and Retina (6.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for MLF2 Gene



Protein tissue co-expression partners for MLF2 Gene

NURSA nuclear receptor signaling pathways regulating expression of MLF2 Gene:

MLF2

SOURCE GeneReport for Unigene cluster for MLF2 Gene:

Hs.524214

mRNA Expression by UniProt/SwissProt for MLF2 Gene:

Q15773-MLF2_HUMAN
Tissue specificity: Ubiquitously expressed.
genes like me logo Genes that share expression patterns with MLF2: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA differential expression in normal tissues for MLF2 Gene

Orthologs for MLF2 Gene

This gene was present in the common ancestor of animals.

Orthologs for MLF2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia MLF2 34 35
  • 99.73 (n)
dog
(Canis familiaris)
Mammalia MLF2 34 35
  • 92.85 (n)
oppossum
(Monodelphis domestica)
Mammalia MLF2 35
  • 92 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia MLF2 35
  • 91 (a)
OneToOne
cow
(Bos Taurus)
Mammalia MLF2 34 35
  • 90.82 (n)
rat
(Rattus norvegicus)
Mammalia Mlf2 34
  • 90.69 (n)
mouse
(Mus musculus)
Mammalia Mlf2 34 16 35
  • 89.47 (n)
chicken
(Gallus gallus)
Aves MLF2 34 35
  • 77.82 (n)
lizard
(Anolis carolinensis)
Reptilia MLF2 35
  • 85 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia mlf2 34
  • 68.76 (n)
Str.1911 34
zebrafish
(Danio rerio)
Actinopterygii mlf2 34 35
  • 61.83 (n)
wufj39f09 34
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.10102 34
fruit fly
(Drosophila melanogaster)
Insecta Mlf 35
  • 19 (a)
OneToMany
Species where no ortholog for MLF2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for MLF2 Gene

ENSEMBL:
Gene Tree for MLF2 (if available)
TreeFam:
Gene Tree for MLF2 (if available)

Paralogs for MLF2 Gene

Paralogs for MLF2 Gene

(2) SIMAP similar genes for MLF2 Gene using alignment to 5 proteins:

Pseudogenes.org Pseudogenes for MLF2 Gene

genes like me logo Genes that share paralogs with MLF2: view

Variants for MLF2 Gene

Sequence variations from dbSNP and Humsavar for MLF2 Gene

SNP ID Clin Chr 12 pos Sequence Context AA Info Type
VAR_036429 A colorectal cancer sample
rs1050599 -- 6,748,201(-) TGGAT(C/T)TTTGC nc-transcript-variant, utr-variant-3-prime
rs1050629 -- 6,748,123(-) GGTTC(C/T)TAACT nc-transcript-variant, utr-variant-3-prime
rs1050640 -- 6,748,082(-) AGAAT(C/T)TTCCC nc-transcript-variant, utr-variant-3-prime
rs1050643 -- 6,748,073(-) CCTAC(A/C)CCCTT nc-transcript-variant, utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for MLF2 Gene

Variant ID Type Subtype PubMed ID
esv2761725 CNV gain 21179565
esv3580394 CNV gain 25503493
nsv557257 CNV loss 21841781
nsv832322 CNV loss 17160897
nsv832323 CNV loss 17160897

Variation tolerance for MLF2 Gene

Residual Variation Intolerance Score: 48.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.68; 14.54% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for MLF2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MLF2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MLF2 Gene

Disorders for MLF2 Gene

MalaCards: The human disease database

(2) MalaCards diseases for MLF2 Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
myeloid leukemia
  • leukemia myelogenous
leukemia
- elite association - COSMIC cancer census association via MalaCards
Search MLF2 in MalaCards View complete list of genes associated with diseases

Relevant External Links for MLF2

Genetic Association Database (GAD)
MLF2
Human Genome Epidemiology (HuGE) Navigator
MLF2
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
MLF2
genes like me logo Genes that share disorders with MLF2: view

No data available for UniProtKB/Swiss-Prot and Genatlas for MLF2 Gene

Publications for MLF2 Gene

  1. cDNA cloning, tissue distribution, and chromosomal localization of myelodysplasia/myeloid leukemia factor 2 (MLF2). (PMID: 8661158) Kuefer M.U. … Morris S.W. (Genomics 1996) 2 3 4 64
  2. Use of expression data and the CGEMS genome-wide breast cancer association study to identify genes that may modify risk in BRCA1/2 mutation carriers. (PMID: 18095154) Walker L.C. … Spurdle A.B. (Breast Cancer Res. Treat. 2008) 3 46 64
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
  4. Proteomic analysis and identification of cellular interactors of the giant ubiquitin ligase HERC2. (PMID: 25476789) Galligan J.T. … Howley P.M. (J. Proteome Res. 2015) 3 64
  5. Characterization of the Cardiac Overexpression of HSPB2 Reveals Mitochondrial and Myogenic Roles Supported by a Cardiac HspB2 Interactome. (PMID: 26465331) Grose J.H. … Benjamin I.J. (PLoS ONE 2015) 3 64

Products for MLF2 Gene

Sources for MLF2 Gene

Content
Loading form....