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Aliases for MLF2 Gene

Aliases for MLF2 Gene

  • Myeloid Leukemia Factor 2 2 3 5
  • Myelodysplasia-Myeloid Leukemia Factor 2 3 4
  • NTN4 3

External Ids for MLF2 Gene

Previous GeneCards Identifiers for MLF2 Gene

  • GC12P006734
  • GC12P006859
  • GC12M006553
  • GC12M006857

Summaries for MLF2 Gene

GeneCards Summary for MLF2 Gene

MLF2 (Myeloid Leukemia Factor 2) is a Protein Coding gene. Diseases associated with MLF2 include Myeloid Leukemia and Leukemia. An important paralog of this gene is MLF1.

Additional gene information for MLF2 Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MLF2 Gene

Genomics for MLF2 Gene

GeneHancer (GH) Regulatory Elements for MLF2 Gene

Promoters and enhancers for MLF2 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH12I006762 Promoter/Enhancer 2.6 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 557.4 +1.1 1071 7.2 ZFP64 FEZF1 YY1 E2F8 ZNF143 SP3 NFYC MEF2D ZNF610 GLIS1 MLF2 PTMS ENSG00000219410 ZNF384 CHD4 NCAPD2 EMG1 ENSG00000247853 PTPN6 SPSB2
GH12I006751 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 563.2 +14.3 14320 3 HDGF FOXA2 PKNOX1 SMAD1 ARID4B SIN3A DMAP1 ZNF2 IRF4 YY1 MLF2 CHD4 ATN1 ZNF384 ENSG00000247853 ENSG00000219410 GNB3 P3H3 NOP2 ENSG00000272173
GH12I006788 Promoter/Enhancer 2.3 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 11.3 -23.6 -23601 5 HDGF ELF3 FOXA2 MLX ARID4B SIN3A RAD21 THRB ZNF48 RARA CD4 LPAR5 GPR162 P3H3 PTPN6 ING4 PTMS MLF2 GNB3 PIANP
GH12I006735 Enhancer 1 Ensembl ENCODE 12.6 +31.6 31627 1.1 INSM2 ARID4B RAD21 YY1 ZNF335 SCRT2 ZNF143 RUNX3 MIXL1 ZNF654 PTMS MLF2 LAG3 CD4 GPR162 P3H3 ING4 ENSG00000219410 ACRBP CHD4
GH12I006940 Promoter/Enhancer 2.7 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 4.4 -186.2 -186183 25.9 CLOCK MLX ZFP64 FEZF1 DMAP1 IRF4 YY1 SLC30A9 ZNF213 E2F8 PTPN6 C12orf57 ZNF384 ENSG00000219410 CHD4 ENSG00000247853 SPSB2 SCARNA12 ENSG00000256967 NCAPD2
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around MLF2 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the MLF2 gene promoter:

Genomic Locations for MLF2 Gene

Genomic Locations for MLF2 Gene
19,484 bases
Minus strand

Genomic View for MLF2 Gene

Genes around MLF2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MLF2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MLF2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MLF2 Gene

Proteins for MLF2 Gene

  • Protein details for MLF2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Myeloid leukemia factor 2
    Protein Accession:

    Protein attributes for MLF2 Gene

    248 amino acids
    Molecular mass:
    28147 Da
    Quaternary structure:
    No Data Available

neXtProt entry for MLF2 Gene

Post-translational modifications for MLF2 Gene

No Post-translational modifications

Other Protein References for MLF2 Gene

No data available for DME Specific Peptides for MLF2 Gene

Domains & Families for MLF2 Gene

Gene Families for MLF2 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for MLF2 Gene


Suggested Antigen Peptide Sequences for MLF2 Gene

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the MLF family.
  • Belongs to the MLF family.
genes like me logo Genes that share domains with MLF2: view

Function for MLF2 Gene

Molecular function for MLF2 Gene

GENATLAS Biochemistry:
myelodysplasia/myeloid leukemia factor 2,cytoplasmic,ubiquitously expressed currently no evidence for the involvement of MLF2 in hematologic malignancies

Phenotypes From GWAS Catalog for MLF2 Gene

Gene Ontology (GO) - Molecular Function for MLF2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 23414517
genes like me logo Genes that share ontologies with MLF2: view
genes like me logo Genes that share phenotypes with MLF2: view

Animal Model Products

miRNA for MLF2 Gene

miRTarBase miRNAs that target MLF2

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for MLF2 Gene

Localization for MLF2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for MLF2 Gene

Cytoplasm. Nucleus.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for MLF2 gene
Compartment Confidence
nucleus 5
cytosol 4
plasma membrane 2
extracellular 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Nucleoplasm (3)
  • Cytosol (2)
  • Plasma membrane (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for MLF2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
GO:0005737 cytoplasm IEA --
GO:0016020 membrane IDA,HDA 19946888
genes like me logo Genes that share ontologies with MLF2: view

Pathways & Interactions for MLF2 Gene

No Data Available

Gene Ontology (GO) - Biological Process for MLF2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006952 defense response IMP 8661158
genes like me logo Genes that share ontologies with MLF2: view

No data available for Pathways by source and SIGNOR curated interactions for MLF2 Gene

Drugs & Compounds for MLF2 Gene

No Compound Related Data Available

Transcripts for MLF2 Gene

Unigene Clusters for MLF2 Gene

Myeloid leukemia factor 2:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for MLF2 Gene

ExUns: 1a · 1b · 1c · 1d ^ 2a · 2b ^ 3a · 3b ^ 4 ^ 5 ^ 6a · 6b ^ 7a · 7b ^ 8a · 8b ^ 9a · 9b
SP1: - - -
SP2: -
SP3: - - - - - - -
SP4: - - - - - - -
SP6: -

Relevant External Links for MLF2 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for MLF2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for MLF2 Gene

Protein differential expression in normal tissues from HIPED for MLF2 Gene

This gene is overexpressed in Neutrophil (33.9), Platelet (9.8), and Retina (6.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for MLF2 Gene

Protein tissue co-expression partners for MLF2 Gene

NURSA nuclear receptor signaling pathways regulating expression of MLF2 Gene:


SOURCE GeneReport for Unigene cluster for MLF2 Gene:


mRNA Expression by UniProt/SwissProt for MLF2 Gene:

Tissue specificity: Ubiquitously expressed.

Evidence on tissue expression from TISSUES for MLF2 Gene

  • Nervous system(4.9)
  • Lung(4.7)
  • Liver(4.5)
  • Skin(2.9)
  • Muscle(2.6)
  • Eye(2.5)
  • Kidney(2.3)
  • Intestine(2.2)
genes like me logo Genes that share expression patterns with MLF2: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for MLF2 Gene

Orthologs for MLF2 Gene

This gene was present in the common ancestor of animals.

Orthologs for MLF2 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia MLF2 33 34
  • 99.73 (n)
(Canis familiaris)
Mammalia MLF2 33 34
  • 92.85 (n)
(Monodelphis domestica)
Mammalia MLF2 34
  • 92 (a)
(Ornithorhynchus anatinus)
Mammalia MLF2 34
  • 91 (a)
(Bos Taurus)
Mammalia MLF2 33 34
  • 90.82 (n)
(Rattus norvegicus)
Mammalia Mlf2 33
  • 90.69 (n)
(Mus musculus)
Mammalia Mlf2 33 16 34
  • 89.47 (n)
(Gallus gallus)
Aves MLF2 33 34
  • 77.82 (n)
(Anolis carolinensis)
Reptilia MLF2 34
  • 85 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia mlf2 33
  • 68.76 (n)
Str.1911 33
(Danio rerio)
Actinopterygii mlf2 33 34
  • 61.83 (n)
wufj39f09 33
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.10102 33
fruit fly
(Drosophila melanogaster)
Insecta Mlf 34
  • 19 (a)
Species where no ortholog for MLF2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for MLF2 Gene

Gene Tree for MLF2 (if available)
Gene Tree for MLF2 (if available)

Paralogs for MLF2 Gene

Paralogs for MLF2 Gene

(2) SIMAP similar genes for MLF2 Gene using alignment to 5 proteins: Pseudogenes for MLF2 Gene

genes like me logo Genes that share paralogs with MLF2: view

Variants for MLF2 Gene

Sequence variations from dbSNP and Humsavar for MLF2 Gene

SNP ID Clin Chr 12 pos Variation AA Info Type
VAR_036429 A colorectal cancer sample p.Phe80Cys
rs1000489870 -- 6,751,250(-) C/G intron_variant
rs1000602339 -- 6,754,383(-) T/A upstream_transcript_variant
rs1000866966 -- 6,754,814(-) G/T upstream_transcript_variant
rs1001059298 -- 6,754,045(-) A/G upstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for MLF2 Gene

Variant ID Type Subtype PubMed ID
esv2761725 CNV gain 21179565
esv3580394 CNV gain 25503493
nsv557257 CNV loss 21841781
nsv832322 CNV loss 17160897
nsv832323 CNV loss 17160897

Variation tolerance for MLF2 Gene

Residual Variation Intolerance Score: 48.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.68; 14.54% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for MLF2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MLF2 Gene

Disorders for MLF2 Gene

MalaCards: The human disease database

(2) MalaCards diseases for MLF2 Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
myeloid leukemia
  • leukemia myelogenous
- elite association - COSMIC cancer census association via MalaCards
Search MLF2 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for MLF2

Genetic Association Database
Human Genome Epidemiology Navigator
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with MLF2: view

No data available for UniProtKB/Swiss-Prot and Genatlas for MLF2 Gene

Publications for MLF2 Gene

  1. cDNA cloning, tissue distribution, and chromosomal localization of myelodysplasia/myeloid leukemia factor 2 (MLF2). (PMID: 8661158) Kuefer MU … Morris SW (Genomics 1996) 2 3 4 58
  2. Use of expression data and the CGEMS genome-wide breast cancer association study to identify genes that may modify risk in BRCA1/2 mutation carriers. (PMID: 18095154) Walker LC … Spurdle AB (Breast cancer research and treatment 2008) 3 44 58
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
  4. Modulation of mutant Huntingtin aggregates and toxicity by human myeloid leukemia factors. (PMID: 27840155) Banerjee M … Bhattacharyya NP (The international journal of biochemistry & cell biology 2017) 3 58
  5. Phenotypic and Interaction Profiling of the Human Phosphatases Identifies Diverse Mitotic Regulators. (PMID: 27880917) St-Denis N … Gingras AC (Cell reports 2016) 3 58

Products for MLF2 Gene

Sources for MLF2 Gene

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