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Aliases for MLF2 Gene

Aliases for MLF2 Gene

  • Myeloid Leukemia Factor 2 2 3 5
  • Myelodysplasia-Myeloid Leukemia Factor 2 3 4
  • NTN4 3

External Ids for MLF2 Gene

Previous GeneCards Identifiers for MLF2 Gene

  • GC12P006734
  • GC12P006859
  • GC12M006553
  • GC12M006857

Summaries for MLF2 Gene

GeneCards Summary for MLF2 Gene

MLF2 (Myeloid Leukemia Factor 2) is a Protein Coding gene. Diseases associated with MLF2 include Myeloid Leukemia. An important paralog of this gene is MLF1.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MLF2 Gene

Genomics for MLF2 Gene

Regulatory Elements for MLF2 Gene

Enhancers for MLF2 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around MLF2 on UCSC Golden Path with GeneCards custom track

Promoters for MLF2 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around MLF2 on UCSC Golden Path with GeneCards custom track

Genomic Location for MLF2 Gene

Chromosome:
12
Start:
6,747,992 bp from pter
End:
6,767,475 bp from pter
Size:
19,484 bases
Orientation:
Minus strand

Genomic View for MLF2 Gene

Genes around MLF2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MLF2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MLF2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MLF2 Gene

Proteins for MLF2 Gene

  • Protein details for MLF2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q15773-MLF2_HUMAN
    Recommended name:
    Myeloid leukemia factor 2
    Protein Accession:
    Q15773

    Protein attributes for MLF2 Gene

    Size:
    248 amino acids
    Molecular mass:
    28147 Da
    Quaternary structure:
    No Data Available

neXtProt entry for MLF2 Gene

Proteomics data for MLF2 Gene at MOPED

Post-translational modifications for MLF2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for MLF2 Gene

No data available for DME Specific Peptides for MLF2 Gene

Domains & Families for MLF2 Gene

Protein Domains for MLF2 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for MLF2 Gene

Graphical View of Domain Structure for InterPro Entry

Q15773

UniProtKB/Swiss-Prot:

MLF2_HUMAN :
  • Belongs to the MLF family.
Family:
  • Belongs to the MLF family.
genes like me logo Genes that share domains with MLF2: view

No data available for Gene Families for MLF2 Gene

Function for MLF2 Gene

Molecular function for MLF2 Gene

GENATLAS Biochemistry:
myelodysplasia/myeloid leukemia factor 2,cytoplasmic,ubiquitously expressed currently no evidence for the involvement of MLF2 in hematologic malignancies
genes like me logo Genes that share phenotypes with MLF2: view

Animal Model Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for MLF2 Gene

Localization for MLF2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for MLF2 Gene

Cytoplasm. Nucleus.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for MLF2 Gene COMPARTMENTS Subcellular localization image for MLF2 gene
Compartment Confidence
nucleus 5
cytosol 4
plasma membrane 2
extracellular 1

Gene Ontology (GO) - Cellular Components for MLF2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IEA --
genes like me logo Genes that share ontologies with MLF2: view

Pathways & Interactions for MLF2 Gene

SuperPathways for MLF2 Gene

No Data Available

Gene Ontology (GO) - Biological Process for MLF2 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for MLF2 Gene

Drugs & Compounds for MLF2 Gene

No Compound Related Data Available

Transcripts for MLF2 Gene

Unigene Clusters for MLF2 Gene

Myeloid leukemia factor 2:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for MLF2 Gene

ExUns: 1a · 1b · 1c · 1d ^ 2a · 2b ^ 3a · 3b ^ 4 ^ 5 ^ 6a · 6b ^ 7a · 7b ^ 8a · 8b ^ 9a · 9b
SP1: - - -
SP2: -
SP3: - - - - - - -
SP4: - - - - - - -
SP5:
SP6: -

Relevant External Links for MLF2 Gene

GeneLoc Exon Structure for
MLF2
ECgene alternative splicing isoforms for
MLF2

Expression for MLF2 Gene

mRNA expression in normal human tissues for MLF2 Gene

Protein differential expression in normal tissues from HIPED for MLF2 Gene

This gene is overexpressed in Neutrophil (33.9), Platelet (9.8), and Retina (6.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for MLF2 Gene



SOURCE GeneReport for Unigene cluster for MLF2 Gene Hs.524214

mRNA Expression by UniProt/SwissProt for MLF2 Gene

Q15773-MLF2_HUMAN
Tissue specificity: Ubiquitously expressed.
genes like me logo Genes that share expression patterns with MLF2: view

Protein tissue co-expression partners for MLF2 Gene

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA differential expression in normal tissues for MLF2 Gene

Orthologs for MLF2 Gene

This gene was present in the common ancestor of animals.

Orthologs for MLF2 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia MLF2 35
  • 90.82 (n)
  • 97.57 (a)
MLF2 36
  • 98 (a)
OneToOne
dog
(Canis familiaris)
Mammalia MLF2 35
  • 92.85 (n)
  • 97.98 (a)
MLF2 36
  • 98 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Mlf2 35
  • 89.47 (n)
  • 97.17 (a)
Mlf2 16
Mlf2 36
  • 97 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia MLF2 35
  • 99.73 (n)
  • 100 (a)
MLF2 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Mlf2 35
  • 90.69 (n)
  • 97.17 (a)
oppossum
(Monodelphis domestica)
Mammalia MLF2 36
  • 92 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia MLF2 36
  • 91 (a)
OneToOne
chicken
(Gallus gallus)
Aves MLF2 35
  • 77.82 (n)
  • 86.36 (a)
MLF2 36
  • 87 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia MLF2 36
  • 85 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia mlf2 35
  • 68.76 (n)
  • 70.29 (a)
Str.1911 35
zebrafish
(Danio rerio)
Actinopterygii mlf2 35
  • 61.83 (n)
  • 58.51 (a)
wufj39f09 35
mlf2 36
  • 55 (a)
OneToOne
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.10102 35
fruit fly
(Drosophila melanogaster)
Insecta Mlf 36
  • 19 (a)
OneToMany
Species with no ortholog for MLF2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for MLF2 Gene

ENSEMBL:
Gene Tree for MLF2 (if available)
TreeFam:
Gene Tree for MLF2 (if available)

Paralogs for MLF2 Gene

Paralogs for MLF2 Gene

(2) SIMAP similar genes for MLF2 Gene using alignment to 5 proteins:

Pseudogenes.org Pseudogenes for MLF2 Gene

genes like me logo Genes that share paralogs with MLF2: view

Variants for MLF2 Gene

Sequence variations from dbSNP and Humsavar for MLF2 Gene

SNP ID Clin Chr 12 pos Sequence Context AA Info Type
VAR_036429 A colorectal cancer sample
rs13402 -- 6,753,008(-) GCCGC(C/G)ACCCT nc-transcript-variant, upstream-variant-2KB
rs7301568 -- 6,748,998(+) CAGAG(C/T)GGACA intron-variant
rs12827345 -- 6,750,717(+) CCATG(G/T)TTCCA nc-transcript-variant, reference, missense
rs2178695 -- 6,747,834(+) ACCTG(C/G)CAGTG downstream-variant-500B

Structural Variations from Database of Genomic Variants (DGV) for MLF2 Gene

Variant ID Type Subtype PubMed ID
nsv832322 CNV Loss 17160897
nsv898635 CNV Loss 21882294
nsv832323 CNV Loss 17160897

Variation tolerance for MLF2 Gene

Residual Variation Intolerance Score: 48.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.68; 14.54% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for MLF2 Gene

Disorders for MLF2 Gene

MalaCards: The human disease database

(1) MalaCards diseases for MLF2 Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
myeloid leukemia
  • leukemia myelogenous
- elite association - COSMIC cancer census association via MalaCards
Search MLF2 in MalaCards View complete list of genes associated with diseases

Relevant External Links for MLF2

Genetic Association Database (GAD)
MLF2
Human Genome Epidemiology (HuGE) Navigator
MLF2
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
MLF2
genes like me logo Genes that share disorders with MLF2: view

No data available for UniProtKB/Swiss-Prot and Genatlas for MLF2 Gene

Publications for MLF2 Gene

  1. cDNA cloning, tissue distribution, and chromosomal localization of myelodysplasia/myeloid leukemia factor 2 (MLF2). (PMID: 8661158) Kuefer M.U. … Morris S.W. (Genomics 1996) 2 3 4 67
  2. Proteomic analysis and identification of cellular interactors of the giant ubiquitin ligase HERC2. (PMID: 25476789) Galligan J.T. … Howley P.M. (J. Proteome Res. 2015) 3
  3. Characterization of the Cardiac Overexpression of HSPB2 Reveals Mitochondrial and Myogenic Roles Supported by a Cardiac HspB2 Interactome. (PMID: 26465331) Grose J.H. … Benjamin I.J. (PLoS ONE 2015) 3
  4. A human interactome in three quantitative dimensions organized by stoichiometries and abundances. (PMID: 26496610) Hein M.Y. … Mann M. (Cell 2015) 3
  5. A deep proteomics perspective on CRM1-mediated nuclear export and nucleocytoplasmic partitioning. (PMID: 26673895) KA+rlA+ K. … GAPrlich D. (Elife 2015) 3

Products for MLF2 Gene

Sources for MLF2 Gene

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