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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

MLF2 Gene

protein-coding GIFtS: 55
GCID: GC12M006857

Myeloid Leukemia Factor 2

See related diseases
at

MalaCards

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, ¹⁰fRNAdb, ¹²H-InvDB, ¹³NCBI, ¹⁴NONCODE, and/or ¹⁵RNAdb)
About This Section

Aliases
Myeloid Leukemia Factor 2¹ ²
Myelodysplasia-Myeloid Leukemia Factor 2² ³
NTN4²

External Ids:	HGNC: 7126¹	Entrez Gene: 8079²	Ensembl: ENSG00000089693⁷	OMIM: 601401⁵	UniProtKB: Q15773³

Export aliases for MLF2 gene to outside databases

Previous GC identifers: GC12P006734 GC12P006859 GC12M006553 GC12M006727

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for MLF2 Gene:

MLF2 (myeloid leukemia factor 2) is a protein-coding gene. Diseases associated with MLF2 include coccidiosis, and myeloid leukemia. An important paralog of this gene is MLF1.

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000012.11 NT_009759.16 NC_018923.2

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the MLF2 gene promoter:
AP-2alpha isoform 3 AP-2alpha isoform 4 AP-2alpha isoform 2 AP-2alpha AP-2alphaA
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: MLF2 promoter sequence

Search SABiosciences Chromatin IP Primers for MLF2

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat MLF2

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 12p13 Ensembl cytogenetic band: 12p13.31 HGNC cytogenetic band: 12p13

MLF2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
MLF2 gene location

GeneLoc information about chromosome 12 GeneLoc Exon Structure

GeneLoc location for GC12M006857: view genomic region (about GC identifiers)

Start:	6,857,158 bp from pter	End:	6,876,641 bp from pter
Size:	19,484 bases	Orientation:	minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE ¹MOPED, ²PaxDb, and ³MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: MLF2_HUMAN, Q15773 (See protein sequence)

Recommended Name: Myeloid leukemia factor 2

Size: 248 amino acids; 28147 Da

Subcellular location: Cytoplasm (By similarity). Nucleus (By similarity)

Explore the universe of human proteins at neXtProt for MLF2: NX_Q15773

Explore proteomics data for MLF2 at MOPED

Post-translational modifications:

View modification sites using PhosphoSitePlus

View neXtProt modification sites for NX_Q15773

MLF2 Protein expression data from MOPED¹, PaxDb² and MAXQB³ : About this image

REFSEQ proteins: NP_005430.1

ENSEMBL proteins:

ENSP00000203630 ENSP00000438671 ENSP00000446317 ENSP00000439789 ENSP00000443829

ENSP00000442444 ENSP00000403941

Human Recombinant Protein Products for MLF2:

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	Cloud-Clone Corp. Proteins for MLF2

Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005634	nucleus	IEA	--
GO:0005737	cytoplasm	IEA	--

MLF2 for ontologies About GeneDecksing

MLF2 Antibody Products:

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	Cloud-Clone Corp. ELISAs for MLF2 Cloud-Clone Corp. CLIAs for MLF2

(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

1 InterPro protein domain:

IPR019376 Myeloid_leukemia_factor

Graphical View of Domain Structure for InterPro Entry Q15773

ProtoNet protein and cluster: Q15773

UniProtKB/Swiss-Prot: MLF2_HUMAN, Q15773

Similarity: Belongs to the MLF family

MLF2 for domains About GeneDecksing

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
About This Section

Molecular Function:

Genatlas biochemistry entry for MLF2:

myelodysplasia/myeloid leukemia factor 2,cytoplasmic,ubiquitously expressed currently no evidence for the

involvement of MLF2 in hematologic malignancies

Phenotypes:
1 GenomeRNAi human phenotype for MLF2:

Synthetic lethal with Ras

Animal Models:

inGenious Targeting Laboratory - Custom generated mouse model solutions for MLF2

inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for MLF2

genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for MLF2

genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for MLF2

miRNA Products:		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat MLF2
		7 QIAGEN miScript miRNA Assays for microRNAs that regulate MLF2:
		hsa-miR-587 hsa-miR-125a-5p hsa-miR-125b hsa-miR-3613-3p hsa-miR-889 hsa-miR-551b* hsa-miR-4319
		SwitchGear 3'UTR luciferase reporter plasmid: MLF2 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene RNAi products in human, mouse, rat for MLF2
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Clone Products:		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
		OriGene clones in human, mouse for MLF2 (see all 9) OriGene ORF clones in mouse, rat for MLF2 OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector: MLF2 (NM_005439)
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Cell Line Products:		GenScript Custom overexpressing Cell Line Services for MLF2
		Search LifeMap BioReagents cell lines for MLF2

In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MLF2

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
About This Section

Interactions:

Search SABiosciences Gene Network Central^TM Interacting Genes and Proteins Networks for MLF2

STRING Interaction Network Preview (showing 5 interactants - click image to see 10)

5/13 Interacting proteins for MLF2 (Q15773^{2, 3} ENSP00000203630⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 13)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
ABCD3	P28288³, ENSP00000359233⁴	I2D: score=2 STRING: ENSP00000359233
AIFM1	O95831³, ENSP00000287295⁴	I2D: score=2 STRING: ENSP00000287295
BAG2	O95816³, ENSP00000359727⁴	I2D: score=2 STRING: ENSP00000359727
CIAO1	O76071³, ENSP00000418287⁴	I2D: score=2 STRING: ENSP00000418287
MMS19	Q96T76³, ENSP00000359818⁴	I2D: score=2 STRING: ENSP00000359818

About this table

Gene Ontology (GO): 1 biological process term (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0006952	defense response	IMP	8661158

MLF2 for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for MLF2

Search CenterWatch for drugs/clinical trials and news about MLF2

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for MLF2 gene:

NM_005439.2

Unigene Cluster for MLF2:

Myeloid leukemia factor 2

Hs.524214 [show with all ESTs]

Unigene Representative Sequence: BM919311

11 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000203630(uc001qqp.3) ENST00000541305 ENST00000542154 ENST00000539187(uc009zey.1)

ENST00000537126 ENST00000541346 ENST00000540710 ENST00000564181 ENST00000536207

ENST00000536249 ENST00000435120(uc010sfi.2)

miRNA Products:		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat MLF2
		7 QIAGEN miScript miRNA Assays for microRNAs that regulate MLF2:
		hsa-miR-587 hsa-miR-125a-5p hsa-miR-125b hsa-miR-3613-3p hsa-miR-889 hsa-miR-551b* hsa-miR-4319
		SwitchGear 3'UTR luciferase reporter plasmid: MLF2 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene RNAi products in human, mouse, rat for MLF2
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat MLF2

Clone Products:		OriGene clones in human, mouse for MLF2 (see all 9) OriGene ORF clones in mouse, rat for MLF2 OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector: MLF2 (NM_005439)
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for MLF2
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MLF2
		Sirion Biotech Customized lentivirus for stable overexpression of MLF2 Customized lentivirus expression plasmids for stable overexpression of MLF2

Primer Products:		OriGene qPCR primer pairs and template standards for MLF2 OriGene qSTAR qPCR primer pairs in human, mouse for MLF2
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		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat MLF2
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat MLF2

Additional mRNA sequence:

AF070539.1 AK289869.1 AK313998.1 BC000898.2 BC002340.2 BT019393.1 BT019432.1 CR541700.1

NR_026581.1 U57342.1

24/28 DOTS entries (see all 28):

DT.446208 DT.97764865 DT.100808935 DT.100885810 DT.100885826 DT.92470076 DT.40106225 DT.100758921

DT.121122958 DT.100765729 DT.100804081 DT.100885813 DT.121122841 DT.40132214 DT.92470108 DT.95187711

DT.100804491 DT.100885812 DT.100885815 DT.100885819 DT.121122840 DT.86835785 DT.86838340 DT.92470075

24/725 AceView cDNA sequences (see all 725):

BQ934610 BU528376 BQ889734 CR610405 BU735772 CR617192 BM847685 BU730342

BQ953267 BQ672201 AI929809 BM800358 BU683299 BU556949 BE907269 CA419468

BE276219 AI583191 BE018190 CB851959 BQ225328 CR592962 BF769737 BQ430868

GeneLoc Exon Structure

5/6 Alternative Splicing Database (ASD) splice patterns (SP) for MLF2 (see all 6) About this scheme

ExUns:	1a	·	1b	·	1c	·	1d	^	2a	·	2b	^	3a	·	3b	^	4	^	5	^	6a	·	6b	^	7a	·	7b	^	8a	·	8b	^	9a	·	9b
SP1:									-														-								-
SP2:									-
SP3:									-										-		-		-		-		-				-
SP4:									-						-		-		-		-		-		-
SP5:

ECgene alternative splicing isoforms for MLF2

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

MLF2 expression in normal human tissues (normalized intensities) MLF2 embryonic expression: see
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>^2/3
CGAP TAG: CATTGAAGGG

About this image

MLF2 expression in embryonic tissues and stem cells About this table

Data from LifeMap, the Embryonic Development and Stem Cells Database

5/33 selected tissues (see all 33) fully expand


Epithelium
vagina ; squamous epithelial cells

Uterus
uterus, post-menopause ; glandular cells

Brain (Nervous System) fully expand to see all 5 entries
Cerebral Cortex
prefrontal cortex

Testis (Reproductive System) fully expand to see all 4 entries
Leydig Cells Testis Interstitium
seminal vesicle ; glandular cells

Colon (Gastrointestinal Tract) fully expand to see all 4 entries
colon ; peripheral nerve/ganglion

See MLF2 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for MLF2

SOURCE GeneReport for Unigene cluster: Hs.524214

UniProtKB/Swiss-Prot: MLF2_HUMAN, Q15773

Tissue specificity: Ubiquitously expressed

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		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat MLF2

In Situ
Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MLF2

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of animals.

Orthologs for MLF2 gene from 7/17 species (see all 17) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
mouse (Mus musculus)	Mammalia	Mlf2^{1 , 5}	myeloid leukemia factor 2^{1, 5}	89.47(n)¹ 97.17(a)¹		6 (59.17 cM)⁵ 30853¹ NM_001170341.1¹ NP_001163812.1¹ 124931388⁵
chicken (Gallus gallus)	Aves	MLF2¹	myeloid leukemia factor 2	77.82(n) 86.36(a)		418284 NM_001030776.1 NP_001025947.1
lizard (Anolis carolinensis)	Reptilia	MLF2⁶	Uncharacterized protein	86(a)	1 ↔ 1	GL343453.1(109015-120074)
African clawed frog (Xenopus laevis)	Amphibia	CD303631.1²	--	71.95(n)		CD303631.1
zebrafish (Danio rerio)	Actinopterygii	wufj39f09²	Transcribed sequence with weak similarity to protein more	78.91(n)		CK138593.1
fruit fly (Drosophila melanogaster)	Insecta	Mlf¹	Myelodysplasia/myeloid leukemia factor	48.73(n) 38.58(a)		36750 NM_206125.2 NP_995847.1
worm (Caenorhabditis elegans)	Secernentea	Y17G7B.17⁶	Protein Y17G7B.17	23(a)	1 → many	II(12092422-12099989)

ENSEMBL Gene Tree for MLF2 (if available)
TreeFam Gene Tree for MLF2 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for MLF2 gene

MLF1²

2 SIMAP similar genes for MLF2 using alignment to 5 protein entries: MLF2_HUMAN (see all proteins):

MLF1 DKFZp313B1621

MLF2 for paralogs About GeneDecksing

1 Pseudogenes.org Pseudogene for MLF2
PGOHUM00000260417

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, ⁴UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 12 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
VAR_036429⁴		A colorectal cancer sample⁴	--	see VAR_036429	2	F C	mis⁴		0	--	--	--	--
rs11064362^1,2	C,F,H	--	6856696(+)	`TCTAGG/TCTCCT`	2	--	ds500¹		8		NS NA WA	914
rs77899180^1,2	F	--	6856795(+)	`GGTTAT/CCTGAA`	2	--	ds500¹		1		WA	118
rs191728728^1,2		--	6856887(+)	`CCCAAC/TACATC`	2	--	ds500¹		0	--	--	--	--
rs141584575^1,2		--	6856960(+)	`TCACGA/CCCCAG`	2	--	ds500¹		0	--	--	--	--
rs2178695^1,2	C,F,A	--	6857000(+)	`ACCTGG/CCAGTG`	2	--	ds500¹		7		NA WA CSA EA	366
rs184691535^1,2		--	6857074(+)	`GAGACA/GAGGAA`	2	--	ds500¹		0	--	--	--	--
rs189987031^1,2		--	6857141(+)	`AAAAGG/TACAGC`	2	--	ds500¹		0	--	--	--	--
rs193023210^1,2		--	6857195(+)	`AACACC/GTAGTT`	2	--	ut3¹ nc-transcript-variant		0	--	--	--	--
rs1050629^1,2	C,F,H	--	6857289(-)	`GGTTCC/TTAACT`	2	--	ut3¹ nc-transcript-variantese³		15		MN NS EA CSA WA NA	2256

HapMap Linkage Disequilibrium report for MLF2 (6857158 - 6876641 bp)

Structural Variations
Database of Genomic Variants (DGV) 3 variations for MLF2: About this table

Variant ID	Type	Subtype	PubMed ID
nsv898635	CNV	Loss	21882294
nsv832323	CNV	Loss	17160897
nsv832322	CNV	Loss	17160897

SABiosciences Cancer Mutation PCR Assays

SeqTarget long-range PCR primers for resequencing MLF2

DNA2.0 Custom Variant and Variant Library Synthesis for MLF2

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

OMIM gene information: 601401 OMIM disorders: --

5 diseases for MLF2: About MalaCards

coccidiosis myeloid leukemia leukemia acute leukemia

breast cancer

MLF2 for disorders About GeneDecksing

Genetic Association Database (GAD): MLF2
Human Genome Epidemiology (HuGE) Navigator: MLF2 (2 documents)

Export disorders for MLF2 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

PubMed articles for MLF2 gene, integrated from 9 sources (see all 30):
(articles sorted by number of sources associating them with MLF2)

Utopia: connect your pdf to the dynamic
world of online information

cDNA cloning, tissue distribution, and chromosomal localization of myelodysplasia/myeloid leukemia factor 2 (MLF2). (PubMed id 8661158)^{1, 2, 3} Kuefer M.U.... Morris S.W. (1996)
Use of expression data and the CGEMS genome-wide breast cancer association study to identify genes that may modify risk in BRCA1/2 mutation carriers. (PubMed id 18095154)^{1, 4} Walker L.C....Spurdle A.B. (2007)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S....Malek J. (2004)
Interlaboratory reproducibility of large-scale human p rotein-complex analysis by standardized AP-MS. (PubMed id 23455922)¹ Varjosalo M....Superti-Furga G. (2013)
The SOX2-interactome in brain cancer cells identifies the requirement of MSI2 and USP9X for the growth of brain tumor cells. (PubMed id 23667531)¹ Cox J.L....Rizzino A. (2013)
The functional interactome landscape of the human hist one deacetylase family. (PubMed id 23752268)¹ Joshi P....Cristea I.M. (2013)
MMS19 assembles iron-sulfur proteins required for DNA metabolism and genomic integrity. (PubMed id 22678362)¹ Stehling O....Lill R. (2012)
A high-throughput approach for measuring temporal chan ges in the interactome. (PubMed id 22863883)¹ Kristensen A.R....Foster L.J. (2012)
Initial characterization of the human central proteome. (PubMed id 21269460)² Burkard T.R.... Colinge J. (2011)
System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation. (PubMed id 21406692)² Rigbolt K.T....Blagoev B. (2011)

(in PubMed, OMIM, and NCBI Bookshelf)
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(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 8079	HGNC: 7126	AceView: MLF2	Ensembl:ENSG00000089693	euGenes: HUgn8079
ECgene: MLF2	H-InvDB: MLF2

(According to HUGE)
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(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
PharmGKB entry for MLF2	Pharmacogenomics, SNPs, Pathways
ATLAS Chromosomes in Cancer entry for MLF2	Genetics and Cytogenetics in Oncology and Haematology

Intellectual Property for MLF2 gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

About This Section

Patent Information for MLF2 gene:
Search GeneIP for patents involving MLF2

GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search

(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
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Myeloid Leukemia Factor 2

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MLF2 Gene

Myeloid Leukemia Factor 2

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for MLF2 gene

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for MLF2 gene

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for MLF2 gene

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for MLF2 gene

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for MLF2 gene

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Expression
for MLF2 gene

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for MLF2 gene

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for MLF2 gene

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for MLF2 gene

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for MLF2 gene

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for MLF2 gene