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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

MLF1IP Gene

protein-coding   GIFtS: 54
GCID: GC04M185615

MLF1 Interacting Protein

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
MLF1 Interacting Protein1 2     KSHV Latent Nuclear Antigen-Interacting Protein 12 3
CENPU2 3 5     MLF1-Interacting Protein2 3
Centromere Protein U1 2     CENP502 5
Interphase Centromere Complex Protein 242 3     CENPU502
Polo-Box-Interacting Protein 12 3     KSHV Latent Nuclear Antigen Interacting Protein 12
KLIP12 3     CENP-503
PBIP12 3     CENP-U3
Centromere Protein Of 50 KDa2 3     ICEN243

External Ids:    HGNC: 213481   Entrez Gene: 796822   Ensembl: ENSG000001517257   OMIM: 6115115   UniProtKB: Q71F233   

Export aliases for MLF1IP gene to outside databases

Previous GC identifers: GC00U909457 GC04M185990 GC04M185852 GC04M181368


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for MLF1IP Gene:
The centromere is a specialized chromatin domain, present throughout the cell cycle, that acts as a platform on
which the transient assembly of the kinetochore occurs during mitosis. All active centromeres are characterized
by the presence of long arrays of nucleosomes in which CENPA (MIM 117139) replaces histone H3 (see MIM 601128).
MLF1IP, or CENPU, is an additional factor required for centromere assembly (Foltz et al., 2006 (PubMed
16622419)).(supplied by OMIM, Mar 2008)

GeneCards Summary for MLF1IP Gene: 
MLF1IP (MLF1 interacting protein) is a protein-coding gene. Diseases associated with MLF1IP include cervical adenocarcinoma, and kaposi's sarcoma, and among its related super-pathways are Mitotic Anaphase and Mitotic Prometaphase.

UniProtKB/Swiss-Prot: CENPU_HUMAN, Q71F23
Function: Component of the CENPA-NAC (nucleosome-associated) complex, a complex that plays a central role in
assembly of kinetochore proteins, mitotic progression and chromosome segregation. The CENPA-NAC complex recruits
the CENPA-CAD (nucleosome distal) complex and may be involved in incorporation of newly synthesized CENPA into
centromeres. Plays an important role in the correct PLK1 localization to the mitotic kinetochores. A scaffold
protein responsible for the initial recruitment and maintenance of the kinetochore PLK1 population until its
degradation. Involved in transcriptional repression

Gene Wiki entry for MLF1IP Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000004.11  NT_016354.19  NC_018915.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the MLF1IP gene promoter:
         COUP-TF1   COUP   HNF-4alpha2   Evi-1   HNF-4alpha1   NF-YB   RORalpha1   COUP-TF   c-Myb   ATF6   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidMLF1IP promoter sequence
   Search SABiosciences Chromatin IP Primers for MLF1IP

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat MLF1IP


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 4q35.1   Ensembl cytogenetic band:  4q35.1   HGNC cytogenetic band: 4q35.1

MLF1IP Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
MLF1IP gene location

GeneLoc information about chromosome 4         GeneLoc Exon Structure

GeneLoc location for GC04M185615:  view genomic region     (about GC identifiers)

Start:
185,615,219 bp from pter      End:
185,655,287 bp from pter
Size:
40,069 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: CENPU_HUMAN, Q71F23 (See protein sequence)
Recommended Name: Centromere protein U  
Size: 418 amino acids; 47522 Da
Subunit: Component of the CENPA-NAC complex, at least composed of CENPA, CENPC, CENPH, CENPM, CENPN, CENPT and
MLF1IP/CENPU. The CENPA-NAC complex interacts with the CENPA-CAD complex, composed of CENPI, CENPK, CENPL, CENPO,
CENPP, CENPQ, CENPR and CENPS. Interacts with the N-terminal domain of Kaposi's sarcoma-associated herpesvirus
latent nuclear antigen (LNA). Interacts with MLF1. Interacts with PLK1
Subcellular location: Cytoplasm. Nucleus. Chromosome, centromere, kinetochore. Note=Localizes in the kinetochore
domain of centromeres. Colocalizes with PLK1 at the interzone between the inner and the outer kinetochore plates
Secondary accessions: A2RRD9 Q32Q71 Q9H5G1
Alternative splicing: 2 isoforms:  Q71F23-1   Q71F23-2   

Explore the universe of human proteins at neXtProt for MLF1IP: NX_Q71F23

Explore proteomics data for MLF1IP at MOPED 

Post-translational modifications:

  • UniProtKB: Phosphorylated by PLK1 at Thr-78, creating a self-tethering site that specifically interacts with the polo-box
    domain of PLK1
  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q71F23

  • MLF1IP Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    MLF1IP Protein Expression
    REFSEQ proteins: NP_078905.2  
    ENSEMBL proteins: 
     ENSP00000281453   ENSP00000423248   ENSP00000423167   ENSP00000445862  
    Reactome Protein details: Q71F23
    Human Recombinant Protein Products for MLF1IP: 
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    Cloud-Clone Corp. Proteins for MLF1IP 

    Gene Ontology (GO): 5/6 cellular component terms (GO ID links to tree view) (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000777condensed chromosome kinetochore IEA--
    GO:0005634nucleus IDA--
    GO:0005654nucleoplasm TAS--
    GO:0005737cytoplasm IDA--
    GO:0005813centrosome IDA--

    MLF1IP for ontologies           About GeneDecksing



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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    1 InterPro protein domain:
     IPR025214 NAC_CENP-U

    Graphical View of Domain Structure for InterPro Entry Q71F23

    ProtoNet protein and cluster: Q71F23


    MLF1IP for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: CENPU_HUMAN, Q71F23
    Function: Component of the CENPA-NAC (nucleosome-associated) complex, a complex that plays a central role in
    assembly of kinetochore proteins, mitotic progression and chromosome segregation. The CENPA-NAC complex recruits
    the CENPA-CAD (nucleosome distal) complex and may be involved in incorporation of newly synthesized CENPA into
    centromeres. Plays an important role in the correct PLK1 localization to the mitotic kinetochores. A scaffold
    protein responsible for the initial recruitment and maintenance of the kinetochore PLK1 population until its
    degradation. Involved in transcriptional repression

         Gene Ontology (GO): 1 molecular function term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding ----
         
    MLF1IP for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for MLF1IP:
     Decreased DCP1a protein expres 

    Animal Models:
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       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for MLF1IP 
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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for MLF1IP About   (see all 6)                                                                                              See pathways by source

    SuperPathContained pathways About
    1M Phase
    Mitotic Anaphase0.94
    M Phase0.88
    Separation of Sister Chromatids0.94
    Mitotic M-M/G1 phases0.88
    Mitotic Metaphase and Anaphase0.94
    2Resolution of Sister Chromatid Cohesion
    Resolution of Sister Chromatid Cohesion0.93
    Mitotic Prometaphase0.93
    3Cell Cycle
    Cell Cycle, Mitotic0.84
    Cell Cycle0.84
    4Packaging Of Telomere Ends
    Nucleosome assembly0.46
    Deposition of New CENPA-containing Nucleosomes at the Centromere0.46
    5Meiotic Synapsis
    Chromosome Maintenance0.56

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 BioSystems Pathway for MLF1IP
        PLK1 signaling events


    5/12        Reactome Pathways for MLF1IP (see all 12)
        Mitotic Metaphase and Anaphase
    Mitotic Prometaphase
    Resolution of Sister Chromatid Cohesion
    Nucleosome assembly
    Mitotic Anaphase



    MLF1IP for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for MLF1IP

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/95 Interacting proteins for MLF1IP (Q71F232, 3 ENSP000002814534) via UniProtKB, MINT, STRING, and/or I2D (see all 95)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    GIT1Q9Y2X72, 3MINT-8263192 I2D: score=2 
    NDUFS2O753062, 3MINT-8263214 I2D: score=2 
    ROBO2Q9HCK42, 3MINT-8263247 I2D: score=2 
    SPTBN4Q9H2542, 3MINT-8263258 I2D: score=2 
    TUBB2BQ9BVA12, 3MINT-8263269 I2D: score=2 
    About this table

    Gene Ontology (GO): 5/6 biological process terms (GO ID links to tree view) (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000278mitotic cell cycle TAS--
    GO:0006334nucleosome assembly TAS--
    GO:0006351transcription, DNA-dependent IEA--
    GO:0006355regulation of transcription, DNA-dependent IEA--
    GO:0019048modulation by virus of host morphology or physiology IEA--

    MLF1IP for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for MLF1IP (CENPU)

    Search CenterWatch for drugs/clinical trials and news about MLF1IP / CENPU

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for MLF1IP gene: 
    NM_024629.3  

    Unigene Cluster for MLF1IP:

    MLF1 interacting protein
    Hs.575032  [show with all ESTs]
    Unigene Representative Sequence: AF516710
    7 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000281453(uc003iwp.3 uc003iwq.3 uc003iwr.1) ENST00000510146
    ENST00000502461 ENST00000508095 ENST00000506535 ENST00000514781 ENST00000541971

    miRNA
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    Additional mRNA sequence: 

    AF469667.1 AF516710.1 AK027121.1 AK292297.1 BC031520.1 BC067802.1 BC107744.1 BC131556.1 
    BC141854.1 CR457376.1 DQ907910.1 DQ907911.1 

    12 DOTS entries:

    DT.316104  DT.102829272  DT.316103  DT.121249887  DT.121249897  DT.121249915  DT.92435123  DT.95186944 
    DT.97844298  DT.95147944  DT.86850456  DT.92435121 

    24/165 AceView cDNA sequences (see all 165):

    AA921830 BM819808 BM979578 AA916449 BF792837 CR620591 AA460002 BG031878 
    AF516710 AI081076 BM762718 CR602653 AI005242 AA913400 AA857796 AA412401 
    AA905522 NM_024629 AA176116 AA431194 AA258257 AA625645 BC031520 AA405098 

    GeneLoc Exon Structure

    5/7 Alternative Splicing Database (ASD) splice patterns (SP) for MLF1IP (see all 7)    About this scheme

    ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7a · 7b ^ 8 ^ 9 ^ 10a · 10b ^ 11 ^ 12 ^ 13a · 13b ^ 14 ^ 15a · 15b · 15c
    SP1:        -                                                     -                       -     -                           
    SP2:                                                              -                 -     -     -                           
    SP3:                                                                                                                        
    SP4:                                                  -           -                       -     -                           
    SP5:                                                                                      -     -                           


    ECgene alternative splicing isoforms for MLF1IP

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    MLF1IP expression in normal human tissues (normalized intensities)      MLF1IP embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GATTGAAAAA
    MLF1IP Expression
    About this image


    MLF1IP expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/3 selected tissues (see all 3) fully expand
     
     Testis (Reproductive System)    fully expand to see all 3 entries
             XY Germ Cells Testis Cord
             Testis Interstitium
     
     Gonad
             XY Germ Cells Testis Cord
     
     Blood (Hematopoietic System)
             Proerythroblasts Hematopoietic Bone Marrow

    See MLF1IP Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for MLF1IP

    SOURCE GeneReport for Unigene cluster: Hs.575032

    UniProtKB/Swiss-Prot: CENPU_HUMAN, Q71F23
    Tissue specificity: Expressed at high levels in the testis, fetal liver, thymus, bone marrow and at lower levels
    in the lymph nodes, placenta, colon and spleen. Present in all cell lines examined, including B-cells, T-cells,
    epithelial cells and fibroblast cells. Expressed at high levels in glioblastoma cell lines

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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MLF1IP

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of chordates.

    Orthologs for MLF1IP gene from 4/9 species (see all 9)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Mlf1ip1 , 5 myeloid leukemia factor 1 interacting protein1, 5 71.69(n)1
    57.78(a)1
      8 (26.38 cM)5
    718761  NM_027973.31  NP_082249.11 
     465520555 
    chicken
    (Gallus gallus)
    Aves MLF1IP1 MLF1 interacting protein 55.3(n)
    42.05(a)
      422548  NM_001039299.1  NP_001034388.1 
    lizard
    (Anolis carolinensis)
    Reptilia MLF1IP6
    MLF1 interacting protein
    27(a)
    1 ↔ 1
    5(113234338-113294088)
    zebrafish
    (Danio rerio)
    Actinopterygii LOC7952661 centromere protein U-like 44.01(n)
    28.41(a)
      795266  XM_001335369.3  XP_001335405.3 


    ENSEMBL Gene Tree for MLF1IP (if available)
    TreeFam Gene Tree for MLF1IP (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for MLF1IP gene

    MLF1IP for paralogs           About GeneDecksing


    2 Pseudogenes.org Pseudogenes for MLF1IP
    PGOHUM00000242599 PGOHUM00000258618


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/1096 SNPs in MLF1IP are shown (see all 1096)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 4 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs615208471,2
    C--185614916(+) GATGA-/TGACTCTC 1 -- cds10--------
    rs353431681,2
    C--185615568(+) TATCT-/ATC   
      T
    /TATC
    GTCAC
    2 -- ut310--------
    rs15278701,2
    C,F,A,H--185616631(-) GCATTA/GGTCAT 1 -- int122Minor allele frequency- G:0.18EA NA NS WA 2042
    rs68106001,2
    C,F,A--185616814(+) AAGAAT/CTGTAT 1 -- int18Minor allele frequency- C:0.25NA WA 250
    rs68106351,2
    C,F,A--185616859(+) GGACAT/CGTCAA 1 -- int18Minor allele frequency- C:0.22NA WA 250
    rs1470619741,2
    C--185617180(+) AACAA-/AGTC  
            
    AAACT
    1 -- int10--------
    rs1160016191,2
    F--185617265(+) TTGCTG/ATTTAA 1 -- int11Minor allele frequency- A:0.02WA 118
    rs1473281071,2
    --185617335(+) TAATGC/GAATTT 1 -- int10--------
    rs1147365851,2
    F--185617345(+) TTATAC/GAAATA 1 -- int11Minor allele frequency- G:0.03WA 118
    rs1882111501,2
    --185617517(+) AGGCAC/TTGAGC 1 -- int10--------

    HapMap Linkage Disequilibrium report for MLF1IP (185615219 - 185655287 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 6 variations for MLF1IP:    About this table     
    Variant IDTypeSubtypePubMed ID
    esv2667890CNV Deletion23128226
    esv273670CNV Insertion20981092
    esv2474838CNV Insertion19546169
    esv269847CNV Insertion20981092
    nsv830168CNV Loss17160897
    esv28607CNV Loss19812545

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 611511    OMIM disorders: --

    9 diseases for MLF1IP:    About MalaCards
    cervical adenocarcinoma    kaposi's sarcoma    kawasaki disease    sarcoma
    glioblastoma    cervicitis    myeloid leukemia    adenocarcinoma
    leukemia


    MLF1IP for disorders           About GeneDecksing

    Genetic Association Database (GAD): MLF1IP

    Export disorders for MLF1IP gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for MLF1IP gene, integrated from 9 sources (see all 35):
    (articles sorted by number of sources associating them with MLF1IP)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. The CENP-H-I complex is required for the efficient incorporation of newly synthesized CENP-A into centromeres. (PubMed id 16622420)1, 2, 3 Okada M....Fukagawa T. (2006)
    2. The human CENP-A centromeric nucleosome-associated complex. (PubMed id 16622419)1, 2, 3 Foltz D.R....Cleveland D.W. (2006)
    3. cDNA cloning and characterization of a novel gene encoding the MLF1- interacting protein MLF1IP. (PubMed id 15116101)1, 2, 3 Hanissian S.H.... Morris S.W. (2004)
    4. Regulation of myeloid leukemia factor-1 interacting protein (MLF1IP) expression in glioblastoma. (PubMed id 15893739)1, 2, 9 Hanissian S.H....Robertson J.H. (2005)
    5. A genome-wide association study identifies three new r isk loci for Kawasaki disease. (PubMed id 22446962)1, 4 Onouchi Y.... . (2012)
    6. Comprehensive analysis of the ICEN (Interphase Centromere Complex) components enriched in the CENP-A chromatin of human cells. (PubMed id 16716197)1, 2 Izuta H.... Yoda K. (2006)
    7. Self-regulated Plk1 recruitment to kinetochores by the Plk1-PBIP1 interaction is critical for proper chromosome segregation. (PubMed id 17081991)1, 2 Kang Y.H.... Lee K.S. (2006)
    8. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    9. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    10. Identification of a novel cellular transcriptional repressor interacting with the latent nuclear antigen of Kaposi's sarcoma- associated herpesvirus. (PubMed id 12941884)1, 2 Pan H.-Y.... Gao S.-J. (2003)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
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      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 79682 HGNC: 21348 AceView: MLF1IP Ensembl:ENSG00000151725 euGenes: HUgn79682
    ECgene: MLF1IP H-InvDB: MLF1IP

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for MLF1IP Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for MLF1IP gene:
    Search GeneIP for patents involving MLF1IP

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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