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Aliases for MLF1 Gene

Aliases for MLF1 Gene

  • Myeloid Leukemia Factor 1 2 3
  • Myelodysplasia-Myeloid Leukemia Factor 1 4
  • Myeloid Leukemia Factor 1 Variant 1 2
  • Myeloid Leukemia Factor 1 Variant 2 2
  • Myeloid Leukemia Factor 1 Variant 3 2

External Ids for MLF1 Gene

Previous GeneCards Identifiers for MLF1 Gene

  • GC03P155550
  • GC03P159236
  • GC03P159570
  • GC03P159609
  • GC03P159771
  • GC03P158288
  • GC03P155686

Summaries for MLF1 Gene

Entrez Gene Summary for MLF1 Gene

  • This gene encodes an oncoprotein which is thought to play a role in the phenotypic determination of hemopoetic cells. Translocations between this gene and nucleophosmin have been associated with myelodysplastic syndrome and acute myeloid leukemia. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2010]

GeneCards Summary for MLF1 Gene

MLF1 (Myeloid Leukemia Factor 1) is a Protein Coding gene. Diseases associated with MLF1 include leukemia, acute myeloid and myelodysplastic syndrome. Among its related pathways are Transcriptional misregulation in cancer. GO annotations related to this gene include protein domain specific binding. An important paralog of this gene is MLF2.

UniProtKB/Swiss-Prot for MLF1 Gene

  • Involved in lineage commitment of primary hemopoietic progenitors by restricting erythroid formation and enhancing myeloid formation. Interferes with erythropoietin-induced erythroid terminal differentiation by preventing cells from exiting the cell cycle through suppression of CDKN1B/p27Kip1 levels. Suppresses RFWD2/COP1 activity via CSN3 which activates p53 and induces cell cycle arrest. Binds DNA and affects the expression of a number of genes so may function as a transcription factor in the nucleus.

Gene Wiki entry for MLF1 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MLF1 Gene

Genomics for MLF1 Gene

Genomic Location for MLF1 Gene

Start:
158,571,163 bp from pter
End:
158,607,252 bp from pter
Size:
36,090 bases
Orientation:
Plus strand

Genomic View for MLF1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for MLF1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MLF1 Gene

Proteins for MLF1 Gene

  • Protein details for MLF1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P58340-MLF1_HUMAN
    Recommended name:
    Myeloid leukemia factor 1
    Protein Accession:
    P58340
    Secondary Accessions:
    • E9PEU9
    • Q2TLE3
    • Q2TLE5
    • Q8N8F8
    • Q96MH1

    Protein attributes for MLF1 Gene

    Size:
    268 amino acids
    Molecular mass:
    30627 Da
    Quaternary structure:
    • Interacts with CENPU. Also interacts with NRBP1/MADM, YWHAZ/14-3-3-zeta and HNRPUL2/MANP. NRBP1 recruits a serine kinase which phosphorylates both itself and MLF1. Phosphorylated MLF1 then binds to YWHAZ and is retained in the cytoplasm. Retained in the nucleus by binding to HNRPUL2. Binds to COPS3/CSN3 which is required for suppression of RFWD2 and activation of p53.

    Three dimensional structures from OCA and Proteopedia for MLF1 Gene

    Alternative splice isoforms for MLF1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for MLF1 Gene

Proteomics data for MLF1 Gene at MOPED

Post-translational modifications for MLF1 Gene

No data available for DME Specific Peptides for MLF1 Gene

Domains for MLF1 Gene

Protein Domains for MLF1 Gene

InterPro:
ProtoNet:

Graphical View of Domain Structure for InterPro Entry

P58340

UniProtKB/Swiss-Prot:

MLF1_HUMAN :
  • P58340
Family:
  • Belongs to the MLF family.
genes like me logo Genes that share domains with MLF1: view

No data available for Gene Families for MLF1 Gene

Function for MLF1 Gene

Molecular function for MLF1 Gene

GENATLAS Biochemistry: myelodysplasia/myeloid leukemia factor 1.31kDa,fused with NPM1 in myelodysplastic syndrome with translocation t(3;5)(q25.1;q34),cytoplasmic protein expressed in a variety of tissues,homolog to murine hemopoietic lineage switch HLS7
UniProtKB/Swiss-Prot Function: Involved in lineage commitment of primary hemopoietic progenitors by restricting erythroid formation and enhancing myeloid formation. Interferes with erythropoietin-induced erythroid terminal differentiation by preventing cells from exiting the cell cycle through suppression of CDKN1B/p27Kip1 levels. Suppresses RFWD2/COP1 activity via CSN3 which activates p53 and induces cell cycle arrest. Binds DNA and affects the expression of a number of genes so may function as a transcription factor in the nucleus.

Gene Ontology (GO) - Molecular Function for MLF1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 DNA binding ISS --
GO:0005515 protein binding IPI 12176995
GO:0019904 protein domain specific binding IDA 12176995
genes like me logo Genes that share ontologies with MLF1: view

Phenotypes for MLF1 Gene

GenomeRNAi human phenotypes for MLF1:
genes like me logo Genes that share phenotypes with MLF1: view

Animal Model Products

CRISPR Products

miRNA for MLF1 Gene

miRTarBase miRNAs that target MLF1

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for MLF1

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for MLF1 Gene

Localization for MLF1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for MLF1 Gene

Cytoplasm. Nucleus. Note=In non-hematopoietic cells, resides primarily in the cytoplasm with some punctate nuclear localization. Shuttles between the cytoplasm and nucleus. In hematopoietic cells, located preferentially in the nucleus. Found in the nucleolus when fused to NPM.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for MLF1 Gene COMPARTMENTS Subcellular localization image for MLF1 gene
Compartment Confidence
nucleus 5
cytosol 3
extracellular 1

Gene Ontology (GO) - Cellular Components for MLF1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus ISS --
GO:0005654 nucleoplasm IDA --
GO:0005737 cytoplasm ISS --
genes like me logo Genes that share ontologies with MLF1: view

Pathways for MLF1 Gene

genes like me logo Genes that share pathways with MLF1: view

Pathways by source for MLF1 Gene

1 KEGG pathway for MLF1 Gene

Gene Ontology (GO) - Biological Process for MLF1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002318 myeloid progenitor cell differentiation ISS --
GO:0006351 transcription, DNA-templated ISS --
GO:0007050 cell cycle arrest IDA 15861129
genes like me logo Genes that share ontologies with MLF1: view

Compounds for MLF1 Gene

(1) Novoseek inferred chemical compound relationships for MLF1 Gene

Compound -log(P) Hits PubMed IDs
glutamine 22.3 1
genes like me logo Genes that share compounds with MLF1: view

Transcripts for MLF1 Gene

Unigene Clusters for MLF1 Gene

Myeloid leukemia factor 1:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for MLF1

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for MLF1 Gene

ExUns: 1a · 1b · 1c · 1d · 1e · 1f ^ 2 ^ 3a · 3b ^ 4 ^ 5 ^ 6 ^ 7a · 7b ^ 8a · 8b ^ 9a · 9b ^ 10a · 10b
SP1: -
SP2: - -
SP3: - - - - -
SP4: - - - -
SP5: - - - -
SP6: - -
SP7: - - -
SP8: - - - -
SP9: - - -
SP10: - - - - -
SP11: - - - - - -

Relevant External Links for MLF1 Gene

GeneLoc Exon Structure for
MLF1
ECgene alternative splicing isoforms for
MLF1

Expression for MLF1 Gene

mRNA expression in normal human tissues for MLF1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for MLF1 Gene

This gene is overexpressed in Testis (14.7), Heart - Atrial Appendage (5.9), and Heart - Left Ventricle (5.3).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for MLF1 Gene

SOURCE GeneReport for Unigene cluster for MLF1 Gene Hs.85195

mRNA Expression by UniProt/SwissProt for MLF1 Gene

P58340-MLF1_HUMAN
Tissue specificity: Most abundant in testis, ovary, skeletal muscle, heart, kidney and colon. Low expression in spleen, thymus and peripheral blood leukocytes
genes like me logo Genes that share expressions with MLF1: view

In Situ Assay Products

Orthologs for MLF1 Gene

This gene was present in the common ancestor of animals.

Orthologs for MLF1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia MLF1 35
  • 99.08 (n)
  • 98.03 (a)
MLF1 36
  • 92 (a)
OneToOne
cow
(Bos Taurus)
Mammalia MLF1 35
  • 88.06 (n)
  • 81.1 (a)
MLF1 36
  • 75 (a)
OneToOne
dog
(Canis familiaris)
Mammalia MLF1 35
  • 84 (n)
  • 76.9 (a)
MLF1 36
  • 73 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Mlf1 35
  • 85.02 (n)
  • 80.52 (a)
Mlf1 16
Mlf1 36
  • 75 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia MLF1 36
  • 51 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia MLF1 36
  • 58 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Mlf1 35
  • 84.02 (n)
  • 77.9 (a)
chicken
(Gallus gallus)
Aves MLF1 35
  • 67.58 (n)
  • 57.03 (a)
MLF1 36
  • 51 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia MLF1 36
  • 71 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia mlf1 35
  • 65.08 (n)
  • 59.74 (a)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.6202 35
zebrafish
(Danio rerio)
Actinopterygii Dr.12489 35
mlf1 35
  • 56.65 (n)
  • 50.21 (a)
mlf1 36
  • 39 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta Mlf 36
  • 18 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea CSA.10379 36
  • 28 (a)
OneToOne
Species with no ortholog for MLF1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for MLF1 Gene

ENSEMBL:
Gene Tree for MLF1 (if available)
TreeFam:
Gene Tree for MLF1 (if available)

Paralogs for MLF1 Gene

Paralogs for MLF1 Gene

Selected SIMAP similar genes for MLF1 Gene using alignment to 8 proteins:

genes like me logo Genes that share paralogs with MLF1: view

Variants for MLF1 Gene

Sequence variations from dbSNP and Humsavar for MLF1 Gene

SNP ID Clin Chr 03 pos Sequence Context AA Info Type MAF
rs4875 -- 158,602,808(+) ATAGG(C/T)GATGC synonymous-codon, reference
rs15967 - 158,602,914(-) GCCAG(G/T)ATTCT missense, reference
rs959654 -- 158,575,194(+) CAAGG(A/T)GCCAT intron-variant
rs1075551 -- 158,588,838(-) CAACA(C/T)CCTCA intron-variant
rs1131696 -- 158,588,925(-) GACTC(A/C)ATGTC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for MLF1 Gene

Variant ID Type Subtype PubMed ID
nsv877690 CNV Gain 21882294
nsv877691 CNV Gain 21882294

Relevant External Links for MLF1 Gene

HapMap Linkage Disequilibrium report
MLF1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MLF1 Gene

Disorders for MLF1 Gene

MalaCards: The human disease database

MalaCards: The human disease database. (4) Diseases for MLF1 Gene including...

Search for MLF1 Gene in MalaCards »

(1) OMIM Diseases for MLF1 Gene (601402)

UniProtKB/Swiss-Prot

MLF1_HUMAN
  • Note=A chromosomal aberration involving MLF1 is a cause of myelodysplastic syndrome (MDS). Translocation t(3;5)(q25.1;q34) with NPM1/NPM.

(1) University of Copenhagen DISEASES for MLF1 Gene

(8) Novoseek inferred disease relationships for MLF1 Gene

Disease -log(P) Hits PubMed IDs
myeloid leukemia 84.2 17
erythroleukemia 66.2 1
myelodysplastic syndromes 62.6 3
leukemogenesis 50.9 3
acute leukemia 32.3 1

Relevant External Links for MLF1

Genetic Association Database (GAD)
MLF1
Human Genome Epidemiology (HuGE) Navigator
MLF1
genes like me logo Genes that share disorders with MLF1: view

Publications for MLF1 Gene

  1. The t(3;5)(q25.1;q34) of myelodysplastic syndrome and acute myeloid leukemia produces a novel fusion gene, NPM-MLF1. (PMID: 8570204) Yoneda-Kato N. … Morris S.W. (Oncogene 1996) 2 3 4 23
  2. Myeloid leukemia factor 1 regulates p53 by suppressing COP1 via COP9 signalosome subunit 3. (PMID: 15861129) Yoneda-Kato N. … Kato J.-Y. (EMBO J. 2005) 3 4 23
  3. Detection of NPM/MLF1 fusion in t(3;5)-positive acute myeloid leukemia and myelodysplasia. (PMID: 14506644) Arber D.A. … Slovak M.L. (Hum. Pathol. 2003) 3 23
  4. Detection of t(3;5) and NPM1/MLF1 rearrangement in an elderly patient with acute myeloid leukemia: clinical and laboratory study with review of the literature. (PMID: 20471513) Lim G. … Park T.S. (Cancer Genet. Cytogenet. 2010) 3 23
  5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4

Products for MLF1 Gene

Sources for MLF1 Gene

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