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MLF1 Gene

protein-coding   GIFtS: 64
GCID: GC03P158288

Myeloid Leukemia Factor 1

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Myeloid Leukemia Factor 11 2
Myelodysplasia-Myeloid Leukemia Factor 12 3
Myeloid Leukemia Factor 1 Variant 11
Myeloid Leukemia Factor 1 Variant 21
Myeloid Leukemia Factor 1 Variant 31

External Ids:    HGNC: 71251   Entrez Gene: 42912   Ensembl: ENSG000001780537   OMIM: 6014025   UniProtKB: P583403   

Export aliases for MLF1 gene to outside databases

Previous GC identifers: GC03P155550 GC03P159236 GC03P159570 GC03P159609 GC03P159771 GC03P155686


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for MLF1 Gene:
This gene encodes an oncoprotein which is thought to play a role in the phenotypic determination of hemopoetic
cells. Translocations between this gene and nucleophosmin have been associated with myelodysplastic syndrome and
acute myeloid leukemia. Multiple transcript variants encoding different isoforms have been found for this gene.
(provided by RefSeq, Sep 2010)

GeneCards Summary for MLF1 Gene:
MLF1 (myeloid leukemia factor 1) is a protein-coding gene. Diseases associated with MLF1 include myelodysplastic syndromes, and myeloid leukemia. GO annotations related to this gene include protein domain specific binding. An important paralog of this gene is MLF2.

UniProtKB/Swiss-Prot: MLF1_HUMAN, P58340
Function: Involved in lineage commitment of primary hemopoietic progenitors by restricting erythroid formation and
enhancing myeloid formation. Interferes with erythropoietin-induced erythroid terminal differentiation by
preventing cells from exiting the cell cycle through suppression of CDKN1B/p27Kip1 levels. Suppresses RFWD2/COP1
activity via CSN3 which activates p53 and induces cell cycle arrest. Binds DNA and affects the expression of a
number of genes so may function as a transcription factor in the nucleus

Gene Wiki entry for MLF1 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000003.12  NT_005612.17  NC_018914.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the MLF1 gene promoter:
         Pax-6   NCX/Ncx   POU6F1 (c2)   FOXL1   POU2F1   POU2F1b   POU2F1a   FOXJ2 (long isoform)   FOXJ2   POU2F1c   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidMLF1 promoter sequence
   Search Chromatin IP Primers for MLF1

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat MLF1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 3q25.1   Ensembl cytogenetic band:  3q25.32   HGNC cytogenetic band: 3q25

MLF1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
MLF1 gene location

GeneLoc information about chromosome 3         GeneLoc Exon Structure

GeneLoc location for GC03P158288:  view genomic region     (about GC identifiers)

Start:
158,288,952 bp from pter      End:
158,325,041 bp from pter
Size:
36,090 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: MLF1_HUMAN, P58340 (See protein sequence)
Recommended Name: Myeloid leukemia factor 1  
Size: 268 amino acids; 30627 Da
Subunit: Interacts with CENPU. Also interacts with NRBP1/MADM, YWHAZ/14-3-3-zeta and HNRPUL2/MANP. NRBP1 recruits
a serine kinase which phosphorylates both itself and MLF1. Phosphorylated MLF1 then binds to YWHAZ and is
retained in the cytoplasm. Retained in the nucleus by binding to HNRPUL2. Binds to COPS3/CSN3 which is required
for suppression of RFWD2 and activation of p53
2 PDB 3D structures from and Proteopedia for MLF1:
3UAL (3D)        3UBW (3D)    
Secondary accessions: E9PEU9 Q2TLE3 Q2TLE5 Q8N8F8 Q96MH1
Alternative splicing: 5 isoforms:  P58340-1   P58340-2   P58340-3   P58340-5   P58340-4   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for MLF1: NX_P58340

Explore proteomics data for MLF1 at MOPED

Post-translational modifications: 

  • Phosphorylation is required for binding to YWHAZ (By similarity)1
  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See MLF1 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (6 alternative transcripts): 
    NP_001123628.1  NP_001123629.1  NP_001182361.1  NP_001182362.1  NP_001182363.1  NP_071888.1  

    ENSEMBL proteins: 
     ENSP00000420410   ENSP00000348157   ENSP00000417835   ENSP00000352025   ENSP00000419636  
     ENSP00000419637   ENSP00000419775   ENSP00000420134   ENSP00000418595   ENSP00000417141  
     ENSP00000417777   ENSP00000419241   ENSP00000417278   ENSP00000376568  

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    Cloud-Clone Corp. CLIAs for MLF1


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    1 InterPro protein domain:
     IPR019376 Myeloid_leukemia_factor

    Graphical View of Domain Structure for InterPro Entry P58340

    ProtoNet protein and cluster: P58340

    UniProtKB/Swiss-Prot: MLF1_HUMAN, P58340
    Similarity: Belongs to the MLF family


    MLF1 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: MLF1_HUMAN, P58340
    Function: Involved in lineage commitment of primary hemopoietic progenitors by restricting erythroid formation and
    enhancing myeloid formation. Interferes with erythropoietin-induced erythroid terminal differentiation by
    preventing cells from exiting the cell cycle through suppression of CDKN1B/p27Kip1 levels. Suppresses RFWD2/COP1
    activity via CSN3 which activates p53 and induces cell cycle arrest. Binds DNA and affects the expression of a
    number of genes so may function as a transcription factor in the nucleus

         Genatlas biochemistry entry for MLF1:
    myelodysplasia/myeloid leukemia factor 1.31kDa,fused with NPM1 in myelodysplastic syndrome with translocation
    t(3;5)(q25.1;q34),cytoplasmic protein expressed in a variety of tissues,homolog to murine hemopoietic lineage
    switch HLS7

         Gene Ontology (GO): 3 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003677DNA binding ISS--
    GO:0005515protein binding IPI12176995
    GO:0019904protein domain specific binding IDA12176995
         
    MLF1 for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for MLF1:
     Increased cell number in G1, s 

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for MLF1
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    hsa-mir-422a (MIRT042653), hsa-mir-378a-3p (MIRT043951)

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    Selected qRT-PCR Assays for microRNAs that regulate MLF1 (see all 25):
    hsa-miR-4311 hsa-miR-181c hsa-miR-4263 hsa-miR-29c hsa-miR-29a hsa-miR-767-5p hsa-miR-885-5p hsa-miR-105
    SwitchGear 3'UTR luciferase reporter plasmidMLF1 3' UTR sequence
    Inhib. RNA
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    Sino Biological Human cDNA Clone for MLF1
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    MLF1_HUMAN, P58340: Cytoplasm. Nucleus. Note=In non-hematopoietic cells, resides primarily in the cytoplasm with
    some punctate nuclear localization. Shuttles between the cytoplasm and nucleus. In hematopoietic cells, located
    preferentially in the nucleus. Found in the nucleolus when fused to NPM
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus5
    cytosol3
    extracellular1

    Gene Ontology (GO): 2 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus ISS--
    GO:0005737cytoplasm ISS--

    MLF1 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for MLF1 About    
    See pathways by source

    SuperPathContained pathways About
    1Transcriptional misregulation in cancer
    Transcriptional misregulation in cancer

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways




    1 Kegg Pathway  (Kegg details for MLF1):
        Transcriptional misregulation in cancer


    MLF1 for pathways           About GeneDecksing

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for MLF1
    Interactions:

        GeneGlobe Interaction Network for MLF1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 15)

    Selected Interacting proteins for MLF1 (P583401, 2, 3 ENSP000003481574) via UniProtKB, MINT, STRING, and/or I2D (see all 19)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    YWHAEP622581, 2, 3, ENSP000002643354EBI-721328,EBI-356498 MINT-8296229 MINT-8296245 MINT-8296207 I2D: score=1 STRING: ENSP00000264335
    YWHAZP631042, 3, ENSP000003095034MINT-16082 MINT-16084 MINT-16083 I2D: score=5 STRING: ENSP00000309503
    NRBP1Q9UHY13, ENSP000002335574I2D: score=3 STRING: ENSP00000233557
    COPS3Q9UNS23, ENSP000002687174I2D: score=2 STRING: ENSP00000268717
    NCLP193383, ENSP000003181954I2D: score=1 STRING: ENSP00000318195
    About this table

    Gene Ontology (GO): 3 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0002318myeloid progenitor cell differentiation ISS--
    GO:0006351transcription, DNA-templated ISS--
    GO:0007050cell cycle arrest IDA15861129

    MLF1 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for MLF1

    1 Novoseek inferred chemical compound relationship for MLF1 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    glutamine 22.3 1 12354791 (1)



    MLF1 for compounds           About GeneDecksing



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for MLF1 gene (6 alternative transcripts): 
    NM_001130156.2  NM_001130157.2  NM_001195432.1  NM_001195433.1  NM_001195434.1  NM_022443.4  

    Unigene Cluster for MLF1:

    Myeloid leukemia factor 1
    Hs.85195  [show with all ESTs]
    Unigene Representative Sequence: BX641078
    15 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000491767 ENST00000355893(uc003fcb.3) ENST00000484955 ENST00000359117(uc003fbz.3 uc003fca.3 uc010hvx.3)
    ENST00000498592 ENST00000477042 ENST00000495452 ENST00000471745 ENST00000497004(uc003fbx.3 uc003fcc.3 uc003fby.3)
    ENST00000469452 ENST00000482628 ENST00000478894 ENST00000487838 ENST00000466246
    ENST00000392822
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    hsa-miR-4311 hsa-miR-181c hsa-miR-4263 hsa-miR-29c hsa-miR-29a hsa-miR-767-5p hsa-miR-885-5p hsa-miR-105
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    Additional mRNA sequence: 

    AK056948.1 AK096889.1 AK297488.1 AK315402.1 AY848700.1 AY848701.1 AY848702.1 BC007045.1 
    BC095437.1 BX641078.1 BX647666.1 L49054.1 

    10 DOTS entries:

    DT.455878  DT.91768024  DT.91768025  DT.75102922  DT.99940054  DT.86853276  DT.91768026  DT.100789206 
    DT.100789207  DT.40117533 

    Selected AceView cDNA sequences (see all 203):

    NM_022443 T19178 BI520174 CA418910 AL120066 AI220091 AA843166 BU674539 
    AI332753 BX647666 AI990398 AI766972 AK056948 AI565360 AI140690 AW131588 
    AI686260 W56334 BG546401 AA974317 BM823975 AA625682 BC007045 BG055075 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for MLF1 (see all 11)    About this scheme

    ExUns: 1a · 1b · 1c · 1d · 1e · 1f ^ 2 ^ 3a · 3b ^ 4 ^ 5 ^ 6 ^ 7a · 7b ^ 8a · 8b ^ 9a · 9b ^ 10a · 10b
    SP1:                                      -                                                                                 
    SP2:                                            -     -                                                                     
    SP3:                                -     -     -     -           -                                                         
    SP4:                                      -     -     -           -                                                         
    SP5:                                -     -     -     -                                                                     


    ECgene alternative splicing isoforms for MLF1

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    MLF1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: AAGGTCCTAG
    MLF1 Expression
    About this image


    MLF1 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 7) fully expand
     
     Testis (Reproductive System)    fully expand to see all 4 entries
             XY Germ Cells Testis Cord
             Testis Interstitium
     
     Neurons
             Mature Rod Cells Outer Nuclear Layer
     
     Gonad
             XY Germ Cells Testis Cord
     
     Skeletal Muscle (Muscoskeletal System)
             Mandibular Arch Muscles
     
     Eye (Sensory Organs)
             Mature Rod Cells Outer Nuclear Layer
    MLF1 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    MLF1 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.85195

    UniProtKB/Swiss-Prot: MLF1_HUMAN, P58340
    Tissue specificity: Most abundant in testis, ovary, skeletal muscle, heart, kidney and colon. Low expression in
    spleen, thymus and peripheral blood leukocytes

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    In Situ
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MLF1

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for MLF1 gene from Selected species (see all 14)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Mlf11 , 5 myeloid leukemia factor 11, 5 85.02(n)1
    80.52(a)1
      3 (30.91 cM)5
    173491  NM_001039543.21  NP_001034632.11 
     673740975 
    chicken
    (Gallus gallus)
    Aves MLF11 myeloid leukemia factor 1 67.58(n)
    57.03(a)
      425019  XM_004943542.1  XP_004943599.1 
    lizard
    (Anolis carolinensis)
    Reptilia MLF16
    myeloid leukemia factor 1
    71(a)
    1 ↔ 1
    3(14152278-14171817)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia mlf11 myeloid leukemia factor 1 65.08(n)
    59.74(a)
      100135130  XM_002933241.2  XP_002933287.1 
    zebrafish
    (Danio rerio)
    Actinopterygii Dr.124892 Transcribed sequence with weak similarity to protein refNP_071888.1 (H.sapiens) myeloid leukemia factor 1 [Homo sapiens] less 75.43(n)    BQ074144.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta Mlf6
    Myelodysplasia/myeloid leukemia factor
    18(a)
    1 → many
    2R(11823398-11827578)


    ENSEMBL Gene Tree for MLF1 (if available)
    TreeFam Gene Tree for MLF1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for MLF1 gene
    MLF22  
    2 SIMAP similar genes for MLF1 using alignment to 8 protein entries:     MLF1_HUMAN (see all proteins):
    DKFZp313B1621    MLF2

    MLF1 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for MLF1 (see all 707)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 3 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1879201591,2
    --158290896(+) ATTCCA/GAATAG 6 -- int10--------
    rs1437632551,2
    --158291042(+) TGGAAC/GTTGCC 6 -- int10--------
    rs46804451,2
    C,F,A,H--158291055(+) GCCAAG/TTGCGC 6 -- int114Minor allele frequency- T:0.44NA NS WA CSA EA 633
    rs1930258781,2
    --158291365(+) GCCATC/TGTTAC 6 -- int10--------
    rs1853557991,2
    C--158291475(+) TAGTTA/TATTTT 6 -- int10--------
    rs1882681191,2
    --158291488(+) TCCCTA/TAAATT 6 -- int10--------
    rs1171532631,2
    F--158291504(+) GGTTTG/ACAATT 6 -- int11Minor allele frequency- A:0.04EA 120
    rs1136644161,2
    C--158291600(+) TCTGTG/-TTTGT 6 -- int11Minor allele frequency- -:0.50CSA 2
    rs1501704551,2
    --158291624(+) GGTCTC/TACTGT 6 -- int10--------
    rs1930673461,2
    --158291788(+) TCGCCG/TTGTTA 6 -- int10--------

    HapMap Linkage Disequilibrium report for MLF1 (158288952 - 158325041 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 2 variations for MLF1:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv877690CNV Gain21882294
    nsv877691CNV Gain21882294

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing MLF1
    DNA2.0 Custom Variant and Variant Library Synthesis for MLF1

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 601402   
    OMIM disorders: 601626  
    UniProtKB/Swiss-Prot: MLF1_HUMAN, P58340
  • Note=A chromosomal aberration involving MLF1 is a cause of myelodysplastic syndrome (MDS). Translocation
    t(3;5)(q25.1;q34) with NPM1/NPM

  • 12 diseases for MLF1:    
    About MalaCards
    myelodysplastic syndromes    myeloid leukemia    leukemia    acute myeloid leukemia
    lung squamous cell carcinoma    acute leukemia    myocardial infarction    choroiditis
    squamous cell carcinoma    esophagitis    multiple myeloma    myeloma

    1 disease from the University of Copenhagen DISEASES database for MLF1:
    Acute myeloid leukemia

    MLF1 for disorders           About GeneDecksing

    8 Novoseek inferred disease relationships for MLF1 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    myeloid leukemia 84.2 21 12354791 (2), 15861129 (2), 8570204 (2), 17008314 (2) (see all 12)
    erythroleukemia 66.2 2 15122318 (1)
    myelodysplastic syndromes 62.6 3 11021751 (2), 8661158 (1)
    leukemogenesis 50.9 3 11021751 (2), 15861129 (1)
    acute leukemia 32.3 1 17121541 (1)
    leukemia 18 2 10391679 (1), 8570204 (1)
    tumors 0 3 15861129 (1), 15893739 (1)
    cancer 0 3 15861129 (1)

    Genetic Association Database (GAD): MLF1
    Human Genome Epidemiology (HuGE) Navigator: MLF1 (2 documents)

    Export disorders for MLF1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for MLF1 gene, integrated from 10 sources (see all 41):
    (articles sorted by number of sources associating them with MLF1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. The t(3;5)(q25.1;q34) of myelodysplastic syndrome and acute myeloid leukemia produces a novel fusion gene, NPM-MLF1. (PubMed id 8570204)1, 2, 3, 9 Yoneda-Kato N.... Morris S.W. (Oncogene 1996)
    2. Myeloid leukemia factor 1 regulates p53 by suppressing COP1 via COP9 signalosome subunit 3. (PubMed id 15861129)1, 2, 9 Yoneda-Kato N.... Kato J.-Y. (EMBO J. 2005)
    3. Structural insights of the MLF1/14-3-3 interaction. (PubMed id 22151054)1, 2 Molzan M.... Ottmann C. (FEBS J. 2012)
    4. Gene variants associated with ischemic stroke: the cardiovascular health study. (PubMed id 19023099)1, 4 Luke M.M....Psaty B.M. ( a journal of cerebral circulation 2009)
    5. Association of gene variants with incident myocardial infarction in the Cardiovascular Health Study. (PubMed id 17975119)1, 4 Shiffman D....Psaty B.M. (Arterioscler. Thromb. Vasc. Biol. 2008)
    6. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    7. cDNA cloning and characterization of a novel gene encoding the MLF1- interacting protein MLF1IP. (PubMed id 15116101)1, 2 Hanissian S.H.... Morris S.W. (Oncogene 2004)
    8. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    9. Detection of t(3;5) and NPM1/MLF1 rearrangement in an elderly patient with acute myeloid leukemia: clinical and laboratory study with review of the literature. (PubMed id 20471513)1, 9 Lim G....Park T.S. (Cancer Genet. Cytogenet. 2010)
    10. Detection of NPM/MLF1 fusion in t(3;5)-positive acute myeloid leukemia and myelodysplasia. (PubMed id 14506644)1, 9 Arber D.A....Slovak M.L. (Hum. Pathol. 2003)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 4291 HGNC: 7125 AceView: MLF1 Ensembl:ENSG00000178053 euGenes: HUgn4291
    ECgene: MLF1 Kegg: 4291 H-InvDB: MLF1

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for MLF1 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for MLF1 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for MLF1 gene:
    Search GeneIP for patents involving MLF1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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