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Aliases for MLF1 Gene

Aliases for MLF1 Gene

  • Myeloid Leukemia Factor 1 2 3 5
  • Myelodysplasia-Myeloid Leukemia Factor 1 4
  • Myeloid Leukemia Factor 1 Variant 1 2
  • Myeloid Leukemia Factor 1 Variant 2 2
  • Myeloid Leukemia Factor 1 Variant 3 2

External Ids for MLF1 Gene

Previous GeneCards Identifiers for MLF1 Gene

  • GC03P155550
  • GC03P159236
  • GC03P159570
  • GC03P159609
  • GC03P159771
  • GC03P158288
  • GC03P155686

Summaries for MLF1 Gene

Entrez Gene Summary for MLF1 Gene

  • This gene encodes an oncoprotein which is thought to play a role in the phenotypic determination of hemopoetic cells. Translocations between this gene and nucleophosmin have been associated with myelodysplastic syndrome and acute myeloid leukemia. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2010]

GeneCards Summary for MLF1 Gene

MLF1 (Myeloid Leukemia Factor 1) is a Protein Coding gene. Diseases associated with MLF1 include Myeloid Leukemia and Leukemia, Acute Myeloid. Among its related pathways are Transcriptional misregulation in cancer. GO annotations related to this gene include protein domain specific binding. An important paralog of this gene is MLF2.

UniProtKB/Swiss-Prot for MLF1 Gene

  • Involved in lineage commitment of primary hemopoietic progenitors by restricting erythroid formation and enhancing myeloid formation. Interferes with erythropoietin-induced erythroid terminal differentiation by preventing cells from exiting the cell cycle through suppression of CDKN1B/p27Kip1 levels. Suppresses RFWD2/COP1 activity via CSN3 which activates p53 and induces cell cycle arrest. Binds DNA and affects the expression of a number of genes so may function as a transcription factor in the nucleus.

Gene Wiki entry for MLF1 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MLF1 Gene

Genomics for MLF1 Gene

Regulatory Elements for MLF1 Gene

Enhancers for MLF1 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH03F158570 0.6 ENCODE 22.9 -0.1 -76 1.5 ATF1 ARNT CREB3L1 SIN3A ZNF2 ZNF143 FOS SP3 NFYC REST MLF1 LOC100996447
GH03F158792 0.5 ENCODE 21.9 +221.6 221645 1.5 GTF2F1 TBP JUN SIN3A MAX CEBPG RFX5 GATA3 RCOR1 TRIM24 MLF1 RARRES1 ENSG00000240207 MFSD1 LXN GFM1 LOC100996447 ENSG00000271778 ENSG00000272247
GH03F158684 0.5 ENCODE 21.5 +114.2 114202 1.1 JUN FEZF1 ZNF664 ZNF316 NFE2 MAFK STAT1 OVOL3 MAFG REST GFM1 MLF1 ENSG00000240207 ENSG00000272087 LXN
GH03F158643 0.5 ENCODE 21.3 +73.6 73595 1.8 HDGF PKNOX1 CREB3L1 MLX ZFP64 ARID4B SIN3A FEZF1 DMAP1 ZNF2 GFM1 MLF1 RARRES1 ENSG00000271778 ENSG00000272440 ENSG00000240207 LXN
GH03F158669 0.9 ENCODE 21.2 +100.6 100563 3.6 HDGF TBP PKNOX1 SIN3A RAD21 ZNF2 GLIS2 ZNF366 ZNF143 ELK4 GFM1 MLF1 ENSG00000240207 LXN
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around MLF1 on UCSC Golden Path with GeneCards custom track

Promoters for MLF1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00001485476 238 1599 ATF1 ARNT CREB3L1 SIN3A ZNF2 ZNF143 FOS ZNF202 SP3 NFYC

Genomic Location for MLF1 Gene

Chromosome:
3
Start:
158,571,163 bp from pter
End:
158,607,252 bp from pter
Size:
36,090 bases
Orientation:
Plus strand

Genomic View for MLF1 Gene

Genes around MLF1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MLF1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MLF1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MLF1 Gene

Proteins for MLF1 Gene

  • Protein details for MLF1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P58340-MLF1_HUMAN
    Recommended name:
    Myeloid leukemia factor 1
    Protein Accession:
    P58340
    Secondary Accessions:
    • E9PEU9
    • Q2TLE3
    • Q2TLE5
    • Q8N8F8
    • Q96MH1

    Protein attributes for MLF1 Gene

    Size:
    268 amino acids
    Molecular mass:
    30627 Da
    Quaternary structure:
    • Interacts with CENPU. Also interacts with NRBP1/MADM, YWHAZ/14-3-3-zeta and HNRPUL2/MANP. NRBP1 recruits a serine kinase which phosphorylates both itself and MLF1. Phosphorylated MLF1 then binds to YWHAZ and is retained in the cytoplasm. Retained in the nucleus by binding to HNRPUL2. Binds to COPS3/CSN3 which is required for suppression of RFWD2 and activation of p53.

    Three dimensional structures from OCA and Proteopedia for MLF1 Gene

    Alternative splice isoforms for MLF1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for MLF1 Gene

Post-translational modifications for MLF1 Gene

No data available for DME Specific Peptides for MLF1 Gene

Domains & Families for MLF1 Gene

Protein Domains for MLF1 Gene

InterPro:
ProtoNet:

Graphical View of Domain Structure for InterPro Entry

P58340

UniProtKB/Swiss-Prot:

MLF1_HUMAN :
  • Belongs to the MLF family.
Family:
  • Belongs to the MLF family.
genes like me logo Genes that share domains with MLF1: view

No data available for Gene Families for MLF1 Gene

Function for MLF1 Gene

Molecular function for MLF1 Gene

GENATLAS Biochemistry:
myelodysplasia/myeloid leukemia factor 1.31kDa,fused with NPM1 in myelodysplastic syndrome with translocation t(3;5)(q25.1;q34),cytoplasmic protein expressed in a variety of tissues,homolog to murine hemopoietic lineage switch HLS7
UniProtKB/Swiss-Prot Function:
Involved in lineage commitment of primary hemopoietic progenitors by restricting erythroid formation and enhancing myeloid formation. Interferes with erythropoietin-induced erythroid terminal differentiation by preventing cells from exiting the cell cycle through suppression of CDKN1B/p27Kip1 levels. Suppresses RFWD2/COP1 activity via CSN3 which activates p53 and induces cell cycle arrest. Binds DNA and affects the expression of a number of genes so may function as a transcription factor in the nucleus.

Gene Ontology (GO) - Molecular Function for MLF1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 DNA binding ISS,IBA --
GO:0005515 protein binding IPI 12176995
GO:0019904 protein domain specific binding IDA 12176995
genes like me logo Genes that share ontologies with MLF1: view
genes like me logo Genes that share phenotypes with MLF1: view

Human Phenotype Ontology for MLF1 Gene

HPO Id HPO Name Alternative Ids Definition Synonyms

Animal Model Products

miRNA for MLF1 Gene

miRTarBase miRNAs that target MLF1

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targets and HOMER Transcription for MLF1 Gene

Localization for MLF1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for MLF1 Gene

Cytoplasm. Nucleus. Note=Shuttles between the cytoplasm and nucleus. {ECO:0000250 UniProtKB:Q9QWV4}.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for MLF1 Gene COMPARTMENTS Subcellular localization image for MLF1 gene
Compartment Confidence
nucleus 5
cytosol 3
extracellular 1

Gene Ontology (GO) - Cellular Components for MLF1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus ISS --
GO:0005737 cytoplasm ISS,IDA --
genes like me logo Genes that share ontologies with MLF1: view

Pathways & Interactions for MLF1 Gene

genes like me logo Genes that share pathways with MLF1: view

Pathways by source for MLF1 Gene

1 KEGG pathway for MLF1 Gene

SIGNOR curated interactions for MLF1 Gene

Activates:

Gene Ontology (GO) - Biological Process for MLF1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002318 myeloid progenitor cell differentiation ISS --
GO:0006351 transcription, DNA-templated ISS --
GO:0006355 regulation of transcription, DNA-templated IBA --
GO:0007049 cell cycle IEA --
GO:0007050 cell cycle arrest IDA 15861129
genes like me logo Genes that share ontologies with MLF1: view

Drugs & Compounds for MLF1 Gene

(1) Drugs for MLF1 Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
genes like me logo Genes that share compounds with MLF1: view

Transcripts for MLF1 Gene

Unigene Clusters for MLF1 Gene

Myeloid leukemia factor 1:
Representative Sequences:

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for MLF1 Gene

ExUns: 1a · 1b · 1c · 1d · 1e · 1f ^ 2 ^ 3a · 3b ^ 4 ^ 5 ^ 6 ^ 7a · 7b ^ 8a · 8b ^ 9a · 9b ^ 10a · 10b
SP1: -
SP2: - -
SP3: - - - - -
SP4: - - - -
SP5: - - - -
SP6: - -
SP7: - - -
SP8: - - - -
SP9: - - -
SP10: - - - - -
SP11: - - - - - -

Relevant External Links for MLF1 Gene

GeneLoc Exon Structure for
MLF1
ECgene alternative splicing isoforms for
MLF1

Expression for MLF1 Gene

mRNA expression in normal human tissues for MLF1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for MLF1 Gene

This gene is overexpressed in Testis (x14.7), Heart - Atrial Appendage (x5.9), and Heart - Left Ventricle (x5.3).

Protein differential expression in normal tissues from HIPED for MLF1 Gene

This gene is overexpressed in Neutrophil (56.1) and Testis (10.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for MLF1 Gene



Protein tissue co-expression partners for MLF1 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of MLF1 Gene:

MLF1

SOURCE GeneReport for Unigene cluster for MLF1 Gene:

Hs.85195

mRNA Expression by UniProt/SwissProt for MLF1 Gene:

P58340-MLF1_HUMAN
Tissue specificity: Most abundant in testis, ovary, skeletal muscle, heart, kidney and colon. Low expression in spleen, thymus and peripheral blood leukocytes.
genes like me logo Genes that share expression patterns with MLF1: view

Primer Products

Orthologs for MLF1 Gene

This gene was present in the common ancestor of animals.

Orthologs for MLF1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia MLF1 34 35
  • 99.08 (n)
cow
(Bos Taurus)
Mammalia MLF1 34 35
  • 88.06 (n)
mouse
(Mus musculus)
Mammalia Mlf1 34 16 35
  • 85.02 (n)
rat
(Rattus norvegicus)
Mammalia Mlf1 34
  • 84.02 (n)
dog
(Canis familiaris)
Mammalia MLF1 34 35
  • 84 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia MLF1 35
  • 58 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia MLF1 35
  • 51 (a)
OneToOne
chicken
(Gallus gallus)
Aves MLF1 34 35
  • 67.58 (n)
lizard
(Anolis carolinensis)
Reptilia MLF1 35
  • 71 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia mlf1 34
  • 65.08 (n)
zebrafish
(Danio rerio)
Actinopterygii mlf1 34 35
  • 56.65 (n)
Dr.12489 34
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.6202 34
fruit fly
(Drosophila melanogaster)
Insecta Mlf 35
  • 18 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea CSA.10379 35
  • 28 (a)
OneToOne
Species where no ortholog for MLF1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for MLF1 Gene

ENSEMBL:
Gene Tree for MLF1 (if available)
TreeFam:
Gene Tree for MLF1 (if available)

Paralogs for MLF1 Gene

Paralogs for MLF1 Gene

(2) SIMAP similar genes for MLF1 Gene using alignment to 8 proteins:

genes like me logo Genes that share paralogs with MLF1: view

Variants for MLF1 Gene

Sequence variations from dbSNP and Humsavar for MLF1 Gene

SNP ID Clin Chr 03 pos Sequence Context AA Info Type
rs10513527 -- 158,583,893(+) ACTTT(A/C)ATTTC intron-variant
rs10575844 -- 158,600,767(+) CAGTA(-/GTA)CTTAG intron-variant
rs10575896 -- 158,600,763(+) TGTTC(-/AGT)AGTAC intron-variant
rs10624254 -- 158,586,811(+) GTGGA(-/AATAT)AATAA intron-variant
rs10637775 -- 158,601,746(+) AGACT(-/CT)GTGTT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for MLF1 Gene

Variant ID Type Subtype PubMed ID
dgv4930n100 CNV gain 25217958
esv2763312 CNV gain 21179565
nsv1004124 CNV gain 25217958
nsv1014381 CNV gain 25217958
nsv1074103 CNV deletion 25765185
nsv1118980 CNV deletion 24896259
nsv954499 CNV deletion 24416366
nsv999408 CNV gain 25217958

Variation tolerance for MLF1 Gene

Residual Variation Intolerance Score: 81.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.79; 58.21% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for MLF1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MLF1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MLF1 Gene

Disorders for MLF1 Gene

MalaCards: The human disease database

(4) MalaCards diseases for MLF1 Gene - From: OMIM, GeneTests, DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
myeloid leukemia
  • leukemia myelogenous
leukemia, acute myeloid
  • leukemia, acute myeloid, somatic
myelodysplastic syndrome
  • myelodysplastic syndrome, somatic
leukemia
- elite association - COSMIC cancer census association via MalaCards
Search MLF1 in MalaCards View complete list of genes associated with diseases

UniProtKB/Swiss-Prot

MLF1_HUMAN
  • Note=A chromosomal aberration involving MLF1 is a cause of myelodysplastic syndrome (MDS). Translocation t(3;5)(q25.1;q34) with NPM1/NPM. {ECO:0000269 PubMed:8570204}.

Relevant External Links for MLF1

Genetic Association Database (GAD)
MLF1
Human Genome Epidemiology (HuGE) Navigator
MLF1
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
MLF1
genes like me logo Genes that share disorders with MLF1: view

No data available for Genatlas for MLF1 Gene

Publications for MLF1 Gene

  1. The t(3;5)(q25.1;q34) of myelodysplastic syndrome and acute myeloid leukemia produces a novel fusion gene, NPM-MLF1. (PMID: 8570204) Yoneda-Kato N. … Morris S.W. (Oncogene 1996) 2 3 4 22 64
  2. Myeloid leukemia factor 1 regulates p53 by suppressing COP1 via COP9 signalosome subunit 3. (PMID: 15861129) Yoneda-Kato N. … Kato J.-Y. (EMBO J. 2005) 3 4 22 64
  3. Structural insights of the MLF1/14-3-3 interaction. (PMID: 22151054) Molzan M. … Ottmann C. (FEBS J. 2012) 3 4 64
  4. Detection of t(3;5) and NPM1/MLF1 rearrangement in an elderly patient with acute myeloid leukemia: clinical and laboratory study with review of the literature. (PMID: 20471513) Lim G. … Park T.S. (Cancer Genet. Cytogenet. 2010) 3 22 64
  5. Gene variants associated with ischemic stroke: the cardiovascular health study. (PMID: 19023099) Luke M.M. … Psaty B.M. (Stroke 2009) 3 46 64

Products for MLF1 Gene

Sources for MLF1 Gene

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