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MLF1 Gene

protein-coding GIFtS: 60

GC03P159771

myeloid leukemia factor 1
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc , and/or ⁷Ensembl, ⁸miRBase)
About This Section

Descriptions
Myelodysplasia-myeloid leukemia factor 1 ^³
myeloid leukemia factor 1 ^²
myeloid leukemia factor 1 variant 1 ^²
myeloid leukemia factor 1 variant 2 ^²
myeloid leukemia factor 1 variant 3 ^²

External Ids
HGNC: 7125¹
Entrez Gene: 4291²
UniProtKB: P58340³
Ensembl: ENSG00000178053⁷

Search outside databases for aliases for MLF1 gene

Previous GC identifers: GC03P155550 GC03P159236 GC03P159570 GC03P159609

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

UniProtKB/Swiss-Prot: MLF1_HUMAN, P58340

Function: Involved in lineage commitment of primary hemopoietic progenitors by restricting

erythroid formation and enhancing myeloid formation. Interferes with erythopoietin-induced

erythroid terminal differentiation by preventing cells from exiting the cell cycle through

suppression of CDKN1B/p27Kip1 levels. Suppresses RFWD2/COP1 activity via CSN3 which activates p53

and induces cell cycle arrest. Binds DNA and affects the expression of a number of genes so may

function as a transcription factor in the nucleus

Gene Wiki entry for MLF1

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
About This Section

Genomic View:

UCSC Golden Path with GeneCards custom track

Transcription factor binding sites upstream to the MLF1 gene

Entrez Gene cytogenetic band: 3q25.1 Ensembl cytogenetic band: 3q25.32 HGNC cytogenetic band: 3q25

MLF1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 3 GeneLoc Exon Structure

GeneLoc location for GC03P159771: (about GC identifiers)

Start:	159,771,677 bp from pter
End:	159,805,877 bp from pter
Size:	34,201 bases
Orientation:	plus strand

RefSeq DNA sequence:

NC_000003.10 NT_005612.15

(According to ¹UniProtKB, and/or Ensembl, Phosphorylation sites according to ²Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
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UniProtKB/Swiss-Prot: MLF1_HUMAN, P58340 (See protein sequence)

Recommended Name: Myeloid leukemia factor 1

Size: 268 amino acids; 30627 Da

Subunit: Interacts with MLF1IP. Also interacts with NRBP1/MADM, YWHAZ/14-3-3-zeta and HNRPUL2/MANP.

NRBP1 recruits a serine kinase which phosphorylates both itself and MLF1. Phosphorylated MLF1 then

binds to YWHAZ and is retained in the cytoplasm. Retained in the nucleus by binding to HNRPUL2.

Binds to COPS3/CSN3 which is required for suppression of RFWD2 and activation of p53

Subcellular location: Cytoplasm. Nucleus. Note=In non-hematopoietic cells, resides primarily in the

cytoplasm with some punctate nuclear localization. Shuttles between the cytoplasm and nucleus. In

hematopoietic cells, located preferentially in the nucleus. Found in the nucleolus when fused to

NPM

Post-translational modifications:

Phosphorylation is required for binding to YWHAZ (By similarity)¹

View phosphorylation sites using PhosphoSite²

REFSEQ proteins (3 alternative transcripts):

NP_001123628.1 NP_001123629.1 NP_071888.1

ENSEMBL proteins:

ENSP00000348157 ENSP00000327144 ENSP00000376568 ENSP00000376567 ENSP00000352025 ENSP00000376566

Human Recombinant Proteins

	Browse Drug Discovery Central at Invitrogen for human recombinant proteins
	Browse Purified and Recombinant Proteins at Millipore
	Browse Human Recombinant Proteins at Sigma-Aldrich
	Browse R&D Systems for human recombinant proteins
	Browse recombinant and purified proteins available from Enzo Life Sciences
	Recombinant Proteins from Abcam (Myeloid leukemia factor 1)
	Human Recombinant Proteins from Abnova (MLF1)

OriGene Purified Recombinant Human Protein: MLF1

2 Gene Ontology (GO) cellular component terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005634	nucleus	ISS	--
GO:0005737	cytoplasm	ISS	--

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Antibodies for MLF1:

	Browse Antibodies Central at Invitrogen
	Browse Millipore's Extensive Line of Mono- and Polyclonal Antibodies
	Sigma-Aldrich Antibodies for MLF1
	Browse R&D Systems for Antibodies
	Antibodies from Abcam (Myeloid leukemia factor 1), each with their Abpromise^SM
	Monoclonal and Polyclonal Antibodies from Abnova (MLF1)
	Novus Biologicals Antibodies for MLF1

Assays for MLF1:

	Browse Invitrogen for biochemical assays
	Browse Kits and Assays available from Millipore
	Browse R&D Systems for biochemical assays
	Browse biochemical assays available from Enzo Life Sciences

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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Graphical View of Domain Structure for InterPro Entry P58340

ProtoNet protein and cluster: P58340

UniProtKB/Swiss-Prot: MLF1_HUMAN, P58340

Similarity: Belongs to the MLF family

(According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
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Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (MLF1)
		Browse for Gene Knock-down Tools from Millipore
		Browse Abnova for Chimera RNAi Products

OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 3): NM_022443

Applied Biosystems Silencer® siRNAs for MLF1

Sigma-Aldrich siRNA and siRNA Panels for MLF1

Sigma-Aldrich shRNA for MLF1

Explore Sigma-Aldrich super-pooled esiRNAs

Clones:		Invitrogen Clones for MLF1
		Browse Clones for the Expression of Recombinant Proteins Available from Millipore

OriGene GFP tagged cDNA clones in CMV expression vector (see all 3): NM_001130156
Myc/DDK tagged cDNA clones in CMV expression vector (see all 3): NM_001130156
untagged cDNA clones in CMV expression vector (see all 3): NM_001130156

Primers:

Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers

OriGene genome-wide validated SYBR primer pairs: NM_022443

UniProtKB/Swiss-Prot: MLF1_HUMAN, P58340

Function: Involved in lineage commitment of primary hemopoietic progenitors by restricting

erythroid formation and enhancing myeloid formation. Interferes with erythopoietin-induced

erythroid terminal differentiation by preventing cells from exiting the cell cycle through

suppression of CDKN1B/p27Kip1 levels. Suppresses RFWD2/COP1 activity via CSN3 which activates p53

and induces cell cycle arrest. Binds DNA and affects the expression of a number of genes so may

function as a transcription factor in the nucleus

Genatlas biochemistry entry for MLF1:

myelodysplasia/myeloid leukemia factor 1.31kDa,fused with NPM1 in myelodysplastic syndrome with

translocation t(3;5)(q25.1;q34),cytoplasmic protein expressed in a variety of tissues,homolog to

murine hemopoietic lineage switch HLS7

2 Gene Ontology (GO) molecular function terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0003677	DNA binding	ISS	--
GO:0019904	protein domain specific binding	IDA	12176995

About this table

(Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to ¹UniProtKB, ²MINT, and/or ³STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section

Gene Network Central^TM Interacting Genes and Proteins Network for MLF1

5/6 Interacting proteins for MLF1 (P58340² ENSP00000327144³) via UniProtKB, MINT, and/or STRING (see all 6 )

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
YWHAZ	P63104²	MINT-16082 MINT-16084 MINT-16083
MLF1IP	ENSP00000281453³	STRING (score=.989)
NPM1	ENSP00000296930³	STRING (score=.845)
ALK	ENSP00000373700³	STRING (score=.718)
NRBP1	ENSP00000369181³	STRING (score=.708)

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5/6 Gene Ontology (GO) biological process terms (links to tree view) (see all 6 ):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0002318	myeloid progenitor cell differentiation	ISS	--
GO:0006350	transcription	ISS	--
GO:0007049	cell cycle	IEA	--
GO:0007050	cell cycle arrest	IDA	15861129
GO:0007275	multicellular organismal development	IEA	--

About this table

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

Browse drugs & compounds from Enzo Life Sciences

Browse Small Molecules at Sigma-Aldrich

Browse Tocris compounds for MLF1

(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Invitrogen, Millipore, and/or Abnova,
siRNAs from Applied Biosystems, Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene,
Tagged/untagged cDNA clones from OriGene,
Expression Assays from Applied Biosystems)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (MLF1)
		Browse for Gene Knock-down Tools from Millipore
		Browse Abnova for Chimera RNAi Products

OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 3): NM_022443

Sigma-Aldrich siRNA and siRNA Panels for MLF1

Sigma-Aldrich shRNA for MLF1

Explore Sigma-Aldrich super-pooled esiRNAs

Applied Biosystems Silencer® siRNAs:

NM_001130156 NM_001130157 NM_022443

REFSEQ mRNAs for MLF1 gene (3 alternative transcripts):

NM_001130156.1 NM_001130157.1 NM_022443.3

Applied Biosystems TaqMan ® Gene Expression Assays:

NM_001130156 NM_001130157 NM_022443

               OriGene GFP tagged cDNA clones in CMV expression vector (see all 3): NM_001130156
                                 Myc/DDK tagged cDNA clones in CMV expression vector (see all 3): NM_001130156
                                 untagged cDNA clones in CMV expression vector (see all 3): NM_001130156

Additional cDNA sequence:

AK056948.1 AK096889.1 AK297488.1 AK315402.1 AY848700.1 AY848701.1 AY848702.1 BC007045.1

BC095437.1 BX641078.1 BX647666.1 L49054.1

10 DOTS entries:

DT.455878 DT.91768024 DT.91768025 DT.75102922 DT.99940054 DT.86853276 DT.91768026 DT.100789206

DT.100789207 DT.40117533

24/203 AceView cDNA sequences (see all 203 ):

BG055075 W56334 BM823975 AW573287 AI686260 BU674539 BG546401 BC007045

AA625682 AW131588 BX647666 AL120066 AK056948 AI332753 CA418910 AA843166

AI220091 NM_022443 T19178 AI766972 BI520174 AA974317 AI565360 AI140690

highest scoring ESTs for MLF1:

AA026647 AA164313 AA164314 AA400562 AA405119 AA463811 AA470924 AI307439 AI744010 AI911434

Unigene Cluster for MLF1:

Myeloid leukemia factor 1

Hs.85195 [show with all ESTs]

Unigene Representative Sequence: BX641078

GeneLoc Exon Structure

5/11 Alternative Splicing Database (ASD) splice patterns (SP) for MLF1 (see all 11 )

ExUns:	1a	·	1b	·	1c	·	1d	·	1e	·	1f	^	2	^	3a	·	3b	^	4	^	5	^	6	^	7a	·	7b	^	8a	·	8b	^	9a	·	9b	^	10a	·	10b
SP1:													-
SP2:															-		-
SP3:											-		-		-		-				-
SP4:													-		-		-				-
SP5:											-		-		-		-

About this scheme

ECgene alternative splicing isoforms for MLF1

6 Ensembl transcripts including schematic representations:

ENST00000355893 ENST00000312827 ENST00000392822 ENST00000392821 ENST00000359117 ENST00000392820

(Experimental results according to ¹GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to ²GeneAnnot , ³GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Expression Assays from Applied Biosystems )
About This Section

MLF1 expression in normal and diseased human tissues

Applied Biosystems TaqMan ® Gene Expression Assays for MLF1

¹ / ² / ³

6 probe-sets matching MLF1 gene

Affymetrix probe-set	Array	# genes	Sensitivity	Specificity	Correlation	Length	Gb_Accession	Consensus	Uniqueness	Score	Rank
Affymetrix probe-set	Array	GeneAnnot data			GeneNote data		GeneTide data
81435_at²^{, 3}	U95-E	1	1.00	1.00	0.98	1.19	AI911434	0.80	1.00	0.91	1
33139_s_at²^{, 3}	U95-A	2	1.00	0.97	0.99	0.83	L49054	0.80	1.00	0.91	1
204783_at²^{, 3}	U133-A	1	1.00	1.00	--	--	AI911434	0.80	1.00	0.91	1
204784_s_at²^{, 3}	U133-A	1	1.00	1.00	--	--	NM_022443	0.60	1.00	0.82	1
204783_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
204784_s_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--

GeneDecks MLF1 for binary patterns associated with the probe-sets selected above

About GeneDecksing

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Data from

(Publications) and GNF BioGPS
About these images
About these images

CGAP SAGE TAG: AAGGTCCTAG

SOURCE GeneReport for Unigene cluster: Hs.85195
Expression variation in blood from EXPOLDB for MLF1
UniProtKB/Swiss-Prot: MLF1_HUMAN, P58340
Tissue specificity: Most abundant in testis, ovary, skeletal muscle, heart, kidney and colon. Low
expression in spleen, thymus and peripheral blood leukocytes

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD and/or ⁵MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
About This Section

Orthologs for MLF1 gene from 5/8 species (see all 8 )

Organism	Gene	Locus	Description	Human Similarity	NCBI accessions
dog (Canis familiaris)	MLF1¹	--	myeloid leukemia factor 1	85.98(n) 78.97(a)	477127 XM_534319.2 XP_534319.2
chimpanzee (Pan troglodytes)	MLF1¹	--	myeloid leukemia factor 1	99.5(n) 98.51(a)	460811 XM_001154028.1 XP_001154028.1
cow (Bos taurus)	MLF1¹	--	myeloid leukemia factor 1	88.68(n) 81.72(a)	533379 NM_001038158.1 NP_001033247.1
rat (Rattus norvegicus)	Mlf1¹	--	myeloid leukemia factor 1	84.71(n) 78.95(a)	310483 XM_227230.4 XP_227230.2
mouse (Mus musculus)	Mlf1^{1, 5}	3 (31.00 cM)⁵	myeloid leukemia factor 1^{1, 5}	85.71(n)¹ 81.2(a)¹	17349¹ NM_001039543.1¹ NP_001034632.1¹ AF009515⁵ AF100171⁵ (see all 8)

About this table Species with no ortholog for MLF1

ENSEMBL Gene Tree for MLF1

(Paralogs according to ¹HomoloGene
and ²Ensembl, Pseudogenes according to ³Pseudogene.org)
About This Section

Paralogs for MLF1 gene

MLF2²

(According to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
About This Section

10/248 NCBI SNPs in MLF1 are shown (see all 248 )
(Click for Applied Biosystems TaqMan ® Genotyping Assay) (see all 99)

AB	SNP ID	Valid	Chr 3 pos	Sequence	Recs	AA Chg	Type	More	Recs	Pop	Total sample	More
AB	Genomic Data				Transcription Data				Allele Frequencies
				--	--	--		--	--			--
	rs1714515^1,2	A,C,F,H,O	159770612(+)	`TAAGGG/ATGGAC`	1	--	ng5¹		7	MN EU EA WA NA	784
	rs7617983^1,2	A,C,F,H	159806410(+)	`ATTTCT/AACTCT`	3	--	ut3¹ ese³		7	NA EU EA WA	560
	rs7628293^1,2	A,C,F,H	159806359(+)	`TATTCA/GCCAGA`	3	--	ut3¹ ese³		4	EU EA WA	380
	rs6804259^1,2	A,C,F,H	159805906(+)	`TTAATA/GTAAAA`	3	--	ut3¹		4	EU EA WA	382
	rs3817373^1,2	C,F,H	159771729(+)	`GCGAGT/ATAACA`	3	--	ut5¹		11	NA EU EA WA	982
	rs16829116^1,2	F,H	159770495(+)	`CTTCAT/CGCTGG`	1	--	ng5¹ tfbs³		7	NA EU EA WA	562
--	rs15967^1,2	C,F	159803397(-)	`GCCAGG/TATTCT`	3	P/T	mis¹		13	EU EA WA NA	2546
	rs1656379^1,2	F,H	159771467(+)	`AGAACA/GAGCTA`	1	--	ng5¹		4	EU EA WA	418
	rs9819631^1,2	C,F	159771504(+)	`AAGCTG/CCCCGG`	1	--	ng5¹		3	NA	142
	rs2276773^1,2	C,F	159770149(+)	`TGCTTA/GTACTA`	1	--	ng5¹		3	NA	140

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HapMap Linkage Disequilibrium images for MLF1 (up to first 250kb)

(in which this Gene is Involved, According to OMIM, UniProtKB, Novoseek, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
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OMIM: 601402 disorders: 601626

UniProtKB/Swiss-Prot: MLF1_HUMAN, P58340

A chromosomal aberration involving MLF1 is a cause of myelodysplastic syndrome (MDS).

Translocation t(3;5)(q25.1;q34) with NPM1/NPM

8 Novoseek disease relationships for MLF1 gene

Disease	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
myeloid leukemia	85.14	21	12354791 (2), 15861129 (2), 8570204 (2), 17008314 (2) (see all 12)
erythroleukemia	67.46	2	15122318 (1)
myelodysplastic syndromes	60.44	3	11021751 (2), 8661158 (1)
leukemogenesis	52.88	3	11021751 (2), 15861129 (1)
acute leukemia	34.46	1	17121541 (1)
leukemia	20.39	2	10391679 (1), 8570204 (1)
cancer	0.00	3	15861129 (1)
tumors	0.00	3	15861129 (1), 15893739 (1)

About this table

Human Genome Epidemiology Navigator: MLF1 (2 documents)

(Possibly Related Articles in Doctor's Guide)
About This Section

(in PubMed. Associations of this gene to articles via ¹Novoseek, ²HGNC, ³Entrez Gene, ⁴UniProtKB/Swiss-Prot, ⁵UniProtKB/TrEMBL, ⁶GAD, and/or ⁷PharmGKB)
About This Section

10/31 PubMed articles for MLF1 gene (see all 31 ):

The t(3;5)(q25.1;q34) of myelodysplastic syndrome and acute myeloid leukemia produces a novel fusion gene, NPM-MLF1. (PubMed id 8570204)^{1, 2, 3, 4} Yoneda-Kato N.... Morris S.W. (1996)
Myeloid leukemia factor 1 regulates p53 by suppressing COP1 via COP9 signalosome subunit 3. (PubMed id 15861129)^{1, 3, 4} Yoneda-Kato N.... Kato J.-Y. (2005)
cDNA cloning and characterization of a novel gene encoding the MLF1- interacting protein MLF1IP. (PubMed id 15116101)^{3, 4} Hanissian S.H.... Morris S.W. (2004)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{3, 4} Gerhard D.S....Malek J. (2004)
Detection of NPM/MLF1 fusion in t(3;5)-positive acute myeloid leukemia and myelodysplasia. (PubMed id 14506644)^{1, 3} Arber D.A....Slovak M.L. (2003)
Gene variants associated with ischemic stroke: the cardiovascular health study. (PubMed id 19023099)³ Luke M.M....Psaty B.M. (2009)
Association of gene variants with incident myocardial infarction in the Cardiovascular Health Study. (PubMed id 17975119)³ Shiffman D....Psaty B.M. (2008)
Shuttling imbalance of MLF1 results in p53 instability and increases susceptibility to oncogenic transformation. (PubMed id 17967869)³ Yoneda-Kato N. and Kato J.Y. (2008)
Non-pathogenic protein aggregates in skeletal muscle in MLF1 transgenic mice. (PubMed id 17854834)³ Li Z.F....Shelton G.D. (2008)
A human protein-protein interaction network: a resource for annotating the proteome. (PubMed id 16169070)³ Stelzl U....Wanker E.E. (2005)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
About This Section

Entrez Gene: 4291	HGNC: 7125	AceView: MLF1	Ensembl:ENSG00000178053	euGenes: HUgn4291
ECgene: MLF1	H-InvDB: MLF1

(According to HUGE)
About This Section

(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
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Name	Description
ATLAS Chromosomes in Cancer entry for MLF1	Genetics and Cytogenetics in Oncology and Haematology

Licensable Technologies for MLF1
(Available from WIS Yeda, Salk, Tufts)

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(Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
Enzo Life Sciences, and/or Tocris Bioscience)
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Products for MLF1:

TaqMan ® Gene Expression Assays

TaqMan ® Genotyping Assays

Free SNP selection tool

Invitrogen iPath Pathways	Invitrogen BLOCK-iT™ RNAi
Invitrogen Antibodies	Invitrogen Assays
Invitrogen Clones	Invitrogen Q-PCR Products
Invitrogen Human Recombinant Kinases	Invitrogen Custom Antibody and Peptide Service
Invitrogen Proteins / Assays / Screening Services	Search Invitrogen catalog for MLF1-related products

	Millipore Custom Antibody & Bulk Services
	Millipore Preclinical / Clinical Development Services
	Millipore Immunoassay Services
	Millipore Target Screening & Profiling Services

	Predesigned and custom siRNAs for MLF1		Antibodies for MLF1
	Explore super-pooled esiRNAs		Browse proteins at Sigma-Aldrich
	Lentivirus-delivered shRNAs for MLF1		Browse small molecules at Sigma-Aldrich
	"Your Favorite Gene" Pathways		feedback

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	Cell Culture Products		ELISAs
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	Multiplex/Array Assay Kits & Reagents		ELISpot Kits & Development Modules
	Recombinant & Natural Proteins

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	shRNA in GFP-retroviral vector

Search Tocris compounds for MLF1

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MLF1 Gene

protein-coding GIFtS: 60

Aliases &
Descriptions
for MLF1

Summaries
for MLF1

Genomic Location
for MLF1

Proteins
for MLF1

Protein Domains/
Families
for MLF1

Gene Function
for MLF1

Pathways & Interactions
for MLF1

Drugs & Compounds
for MLF1

Transcripts
for MLF1

Expression
for MLF1

Orthologs
for MLF1

Paralogs
for MLF1

SNPs/Variants
for MLF1

Disorders & Mutations
for MLF1

Medical News
for MLF1

Publications
for MLF1

Search for MLF1

Genome Databases showing MLF1

Other Databases showing MLF1

Specialized Databases showing MLF1

Licensable Technologies
for MLF1

Services
for MLF1

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

MLF1 Gene

protein-coding GIFtS: 60

Aliases & Descriptionsfor MLF1

Summariesfor MLF1

Genomic Locationfor MLF1

Proteinsfor MLF1

Protein Domains/Familiesfor MLF1

Gene Functionfor MLF1

Pathways & Interactionsfor MLF1

Drugs & Compoundsfor MLF1

Transcriptsfor MLF1

Expression for MLF1

Orthologsfor MLF1

Paralogsfor MLF1

SNPs/Variantsfor MLF1

Disorders & Mutationsfor MLF1

Medical Newsfor MLF1

Publicationsfor MLF1

Search for MLF1

Genome Databases showing MLF1

Other Databases showing MLF1

Specialized Databases showing MLF1

Licensable Technologiesfor MLF1

Servicesfor MLF1

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Aliases &
Descriptions
for MLF1

Summaries
for MLF1

Genomic Location
for MLF1

Proteins
for MLF1

Protein Domains/
Families
for MLF1

Gene Function
for MLF1

Pathways & Interactions
for MLF1

Drugs & Compounds
for MLF1

Transcripts
for MLF1

Expression
for MLF1

Orthologs
for MLF1

Paralogs
for MLF1

SNPs/Variants
for MLF1

Disorders & Mutations
for MLF1

Medical News
for MLF1

Publications
for MLF1

Licensable Technologies
for MLF1

Services
for MLF1