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Aliases for MLEC Gene

Aliases for MLEC Gene

  • Malectin 2 3
  • KIAA0152 2 3 4 6
  • Oligosaccharyltransferase Complex Subunit (Non-Catalytic) 2 3

External Ids for MLEC Gene

Previous Symbols for MLEC Gene

  • KIAA0152

Summaries for MLEC Gene

Entrez Gene Summary for MLEC Gene

  • This gene encodes the carbohydrate-binding protein malectin which is a Type I membrane-anchored endoplasmic reticulum protein. This protein has an affinity for Glc2Man9GlcNAc2 (G2M9) N-glycans and is involved in regulating glycosylation in the endoplasmic reticulum. This protein has also been shown to interact with ribophorin I and may be involved in the directing the degradation of misfolded proteins. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Jan 2015]

GeneCards Summary for MLEC Gene

MLEC (Malectin) is a Protein Coding gene. Among its related pathways are Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein and Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein. GO annotations related to this gene include carbohydrate binding.

UniProtKB/Swiss-Prot for MLEC Gene

  • Carbohydrate-binding protein with a strong ligand preference for Glc2-N-glycan. May play a role in the early steps of protein N-glycosylation (By similarity).

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MLEC Gene

Genomics for MLEC Gene

Genomic Location for MLEC Gene

Start:
120,686,869 bp from pter
End:
120,701,864 bp from pter
Size:
14,996 bases
Orientation:
Plus strand

Genomic View for MLEC Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for MLEC Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MLEC Gene

Regulatory Elements for MLEC Gene

Proteins for MLEC Gene

  • Protein details for MLEC Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q14165-MLEC_HUMAN
    Recommended name:
    Malectin
    Protein Accession:
    Q14165
    Secondary Accessions:

    Protein attributes for MLEC Gene

    Size:
    292 amino acids
    Molecular mass:
    32234 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=BAA09773.2; Type=Erroneous initiation; Evidence={ECO:0000305};

neXtProt entry for MLEC Gene

Proteomics data for MLEC Gene at MOPED

Post-translational modifications for MLEC Gene

  • Modification sites at PhosphoSitePlus
  • Glycosylation at Asn268

Other Protein References for MLEC Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

No data available for DME Specific Peptides for MLEC Gene

Domains for MLEC Gene

Protein Domains for MLEC Gene

InterPro:
ProtoNet:

UniProtKB/Swiss-Prot:

MLEC_HUMAN
Family:
  • Belongs to the malectin family.:
    • Q14165
genes like me logo Genes that share domains with MLEC: view

No data available for Gene Families for MLEC Gene

Function for MLEC Gene

Molecular function for MLEC Gene

UniProtKB/Swiss-Prot Function: Carbohydrate-binding protein with a strong ligand preference for Glc2-N-glycan. May play a role in the early steps of protein N-glycosylation (By similarity).

Gene Ontology (GO) - Molecular Function for MLEC Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0019899 enzyme binding IPI 22988243
GO:0030246 carbohydrate binding ISS --
genes like me logo Genes that share ontologies with MLEC: view

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , Transcription Factor Targeting and HOMER Transcription for MLEC Gene

Localization for MLEC Gene

Subcellular locations from UniProtKB/Swiss-Prot for MLEC Gene

Endoplasmic reticulum membrane; Single-pass type I membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for MLEC Gene COMPARTMENTS Subcellular localization image for MLEC gene
Compartment Confidence
endoplasmic reticulum 5
plasma membrane 2
extracellular 1

Gene Ontology (GO) - Cellular Components for MLEC Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005783 endoplasmic reticulum ISS --
GO:0005789 endoplasmic reticulum membrane TAS --
GO:0016020 membrane IDA 19946888
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with MLEC: view

Pathways for MLEC Gene

genes like me logo Genes that share pathways with MLEC: view

Pathways by source for MLEC Gene

Interacting Proteins for MLEC Gene

STRING Interaction Network Preview (showing 5 interactants - click image to see 8)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000228506%0d%0a9606.ENSP00000340466%0d%0a9606.ENSP00000233616%0d%0a9606.ENSP00000252455%0d%0a9606.ENSP00000251453%0d%0a9606.ENSP00000344818%0d%0a
Selected Interacting proteins: ENSP00000228506 Q14165-MLEC_HUMAN for MLEC Gene via STRING I2D

Gene Ontology (GO) - Biological Process for MLEC Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006457 protein folding TAS --
GO:0018279 protein N-linked glycosylation via asparagine TAS --
GO:0043687 post-translational protein modification TAS --
GO:0044267 cellular protein metabolic process TAS --
genes like me logo Genes that share ontologies with MLEC: view

Transcripts for MLEC Gene

Unigene Clusters for MLEC Gene

Malectin:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for MLEC Gene

ExUns: 1 ^ 2 ^ 3a · 3b ^ 4 ^ 5 ^ 6 ^ 7a · 7b · 7c ^ 8a · 8b
SP1: -
SP2:
SP3: -
SP4: -
SP5: -

Relevant External Links for MLEC Gene

GeneLoc Exon Structure for
MLEC
ECgene alternative splicing isoforms for
MLEC

Expression for MLEC Gene

mRNA expression in normal human tissues for MLEC Gene

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for MLEC Gene

SOURCE GeneReport for Unigene cluster for MLEC Gene Hs.744910

genes like me logo Genes that share expressions with MLEC: view

Orthologs for MLEC Gene

This gene was present in the common ancestor of animals.

Orthologs for MLEC Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia MLEC 36
  • 99.66 (n)
  • 99.66 (a)
MLEC 37
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia MLEC 36
  • 90.22 (n)
  • 96.82 (a)
MLEC 37
  • 98 (a)
OneToOne
dog
(Canis familiaris)
Mammalia MLEC 36
  • 94.93 (n)
  • 97.92 (a)
MLEC 37
  • 98 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Mlec 36
  • 88.47 (n)
  • 94.12 (a)
Mlec 16
Mlec 37
  • 95 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia MLEC 37
  • 95 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Mlec 36
  • 89.5 (n)
  • 95.16 (a)
chicken
(Gallus gallus)
Aves MLEC 36
  • 79.76 (n)
  • 86.23 (a)
MLEC 37
  • 80 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia MLEC 37
  • 86 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia kiaa0152-prov 36
tropical clawed frog
(Silurana tropicalis)
Amphibia mlec 36
  • 79.27 (n)
  • 91.06 (a)
Str.6941 36
zebrafish
(Danio rerio)
Actinopterygii mlec 36
  • 73.82 (n)
  • 82.59 (a)
mlec 37
  • 74 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP007950 36
  • 57.92 (n)
  • 51.25 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG9257 36
  • 55.33 (n)
  • 48.58 (a)
CG9257 37
  • 36 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea F44E2.10 36
  • 49.65 (n)
  • 37.66 (a)
F44E2.10 37
  • 31 (a)
OneToOne
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.1179 36
sea squirt
(Ciona savignyi)
Ascidiacea CSA.8086 37
  • 46 (a)
OneToOne
Species with no ortholog for MLEC:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for MLEC Gene

ENSEMBL:
Gene Tree for MLEC (if available)
TreeFam:
Gene Tree for MLEC (if available)

Paralogs for MLEC Gene

Pseudogenes.org Pseudogenes for MLEC Gene

genes like me logo Genes that share paralogs with MLEC: view

No data available for Paralogs for MLEC Gene

Variants for MLEC Gene

Sequence variations from dbSNP and Humsavar for MLEC Gene

SNP ID Clin Chr 12 pos Sequence Context AA Info Type MAF
rs8295 -- 120,701,585(+) TCTAC(C/T)CTAGT utr-variant-3-prime
rs504403 -- 120,695,234(+) CTGAT(C/G)ACTAT intron-variant
rs547194 -- 120,700,495(+) CTCCT(C/T)CTGTG utr-variant-3-prime
rs560736 -- 120,700,547(-) GCTTC(A/C/T)GTGTA utr-variant-3-prime
rs949443 -- 120,687,188(-) GCCGC(C/T)GGGGA utr-variant-5-prime

Structural Variations from Database of Genomic Variants (DGV) for MLEC Gene

Variant ID Type Subtype PubMed ID
nsv521928 CNV Gain 19592680
nsv899557 CNV Loss 21882294
esv2659790 CNV Deletion 23128226

Relevant External Links for MLEC Gene

HapMap Linkage Disequilibrium report
MLEC

Disorders for MLEC Gene

(1) University of Copenhagen DISEASES for MLEC Gene

Relevant External Links for MLEC

Genetic Association Database (GAD)
MLEC
Human Genome Epidemiology (HuGE) Navigator
MLEC
genes like me logo Genes that share disorders with MLEC: view

No data available for UniProtKB/Swiss-Prot for MLEC Gene

Publications for MLEC Gene

  1. MicroRNAs and target site screening reveals a pre-microRNA-30e variant associated with schizophrenia. (PMID: 20347265) Xu Y. … Liu P. (Schizophr. Res. 2010) 3 49
  2. Prediction of the coding sequences of unidentified human genes. IV. The coding sequences of 40 new genes (KIAA0121-KIAA0160) deduced by analysis of cDNA clones from human cell line KG-1. (PMID: 8590280) Nagase T. … Nomura N. (DNA Res. 1995) 3 4
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  4. Malectin: a novel carbohydrate-binding protein of the endoplasmic reticulum and a candidate player in the early steps of protein N-glycosylation. (PMID: 18524852) Schallus T. … Muhle-Goll C. (Mol. Biol. Cell 2008) 2 3
  5. Ubiquitin-mediated proteolysis of HuR by heat shock. (PMID: 19322201) Abdelmohsen K. … Gorospe M. (EMBO J. 2009) 3

Products for MLEC Gene

Sources for MLEC Gene

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