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Aliases for MLEC Gene

Aliases for MLEC Gene

  • Malectin 2 3 5
  • KIAA0152 2 3 4
  • Oligosaccharyltransferase Complex Subunit (Non-Catalytic) 2 3

External Ids for MLEC Gene

Previous HGNC Symbols for MLEC Gene

  • KIAA0152

Previous GeneCards Identifiers for MLEC Gene

  • GC12P119611
  • GC12P121124
  • GC12P118134

Summaries for MLEC Gene

Entrez Gene Summary for MLEC Gene

  • This gene encodes the carbohydrate-binding protein malectin which is a Type I membrane-anchored endoplasmic reticulum protein. This protein has an affinity for Glc2Man9GlcNAc2 (G2M9) N-glycans and is involved in regulating glycosylation in the endoplasmic reticulum. This protein has also been shown to interact with ribophorin I and may be involved in the directing the degradation of misfolded proteins. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Jan 2015]

GeneCards Summary for MLEC Gene

MLEC (Malectin) is a Protein Coding gene. Among its related pathways are Protein processing in endoplasmic reticulum and TNF Signaling (sino). GO annotations related to this gene include enzyme binding and carbohydrate binding.

UniProtKB/Swiss-Prot for MLEC Gene

  • Carbohydrate-binding protein with a strong ligand preference for Glc2-N-glycan. May play a role in the early steps of protein N-glycosylation (By similarity).

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MLEC Gene

Genomics for MLEC Gene

Regulatory Elements for MLEC Gene

Enhancers for MLEC Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around MLEC on UCSC Golden Path with GeneCards custom track

Promoters for MLEC Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around MLEC on UCSC Golden Path with GeneCards custom track

Genomic Location for MLEC Gene

120,686,869 bp from pter
120,701,864 bp from pter
14,996 bases
Plus strand

Genomic View for MLEC Gene

Genes around MLEC on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MLEC Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MLEC Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MLEC Gene

Proteins for MLEC Gene

  • Protein details for MLEC Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Protein Accession:

    Protein attributes for MLEC Gene

    292 amino acids
    Molecular mass:
    32234 Da
    Quaternary structure:
    No Data Available
    • Sequence=BAA09773.2; Type=Erroneous initiation; Evidence={ECO:0000305};

neXtProt entry for MLEC Gene

Proteomics data for MLEC Gene at MOPED

Post-translational modifications for MLEC Gene

  • Glycosylation at Asn 268
  • Modification sites at PhosphoSitePlus

Other Protein References for MLEC Gene

No data available for DME Specific Peptides for MLEC Gene

Domains & Families for MLEC Gene

Gene Families for MLEC Gene

Protein Domains for MLEC Gene


Suggested Antigen Peptide Sequences for MLEC Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the malectin family.
  • Belongs to the malectin family.
genes like me logo Genes that share domains with MLEC: view

Function for MLEC Gene

Molecular function for MLEC Gene

UniProtKB/Swiss-Prot Function:
Carbohydrate-binding protein with a strong ligand preference for Glc2-N-glycan. May play a role in the early steps of protein N-glycosylation (By similarity).
genes like me logo Genes that share phenotypes with MLEC: view

Animal Models for MLEC Gene

MGI Knock Outs for MLEC:
  • Mlec tm1a(EUCOMM)Wtsi

Animal Model Products

CRISPR Products

miRNA for MLEC Gene

miRTarBase miRNAs that target MLEC

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for MLEC Gene

Localization for MLEC Gene

Subcellular locations from UniProtKB/Swiss-Prot for MLEC Gene

Endoplasmic reticulum membrane; Single-pass type I membrane protein.

Subcellular locations from

Jensen Localization Image for MLEC Gene COMPARTMENTS Subcellular localization image for MLEC gene
Compartment Confidence
endoplasmic reticulum 5
plasma membrane 2

Gene Ontology (GO) - Cellular Components for MLEC Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005789 endoplasmic reticulum membrane TAS --
genes like me logo Genes that share ontologies with MLEC: view

Pathways & Interactions for MLEC Gene

genes like me logo Genes that share pathways with MLEC: view

Pathways by source for MLEC Gene

Interacting Proteins for MLEC Gene

STRING Interaction Network Preview (showing 5 interactants - click image to see 8)
Selected Interacting proteins: ENSP00000228506 Q14165-MLEC_HUMAN for MLEC Gene via STRING I2D

Gene Ontology (GO) - Biological Process for MLEC Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005975 carbohydrate metabolic process IEA --
GO:0043687 post-translational protein modification TAS --
genes like me logo Genes that share ontologies with MLEC: view

No data available for SIGNOR curated interactions for MLEC Gene

Drugs & Compounds for MLEC Gene

No Compound Related Data Available

Transcripts for MLEC Gene

Unigene Clusters for MLEC Gene

Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for MLEC Gene

ExUns: 1 ^ 2 ^ 3a · 3b ^ 4 ^ 5 ^ 6 ^ 7a · 7b · 7c ^ 8a · 8b
SP1: -
SP3: -
SP4: -
SP5: -

Relevant External Links for MLEC Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for MLEC Gene

mRNA expression in normal human tissues for MLEC Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for MLEC Gene

This gene is overexpressed in Peripheral blood mononuclear cells (7.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for MLEC Gene

SOURCE GeneReport for Unigene cluster for MLEC Gene Hs.744910

genes like me logo Genes that share expression patterns with MLEC: view

Protein tissue co-expression partners for MLEC Gene

- Elite partner

Primer Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for MLEC Gene

Orthologs for MLEC Gene

This gene was present in the common ancestor of animals.

Orthologs for MLEC Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia MLEC 35
  • 90.22 (n)
  • 96.82 (a)
  • 98 (a)
(Canis familiaris)
Mammalia MLEC 35
  • 94.93 (n)
  • 97.92 (a)
  • 98 (a)
(Mus musculus)
Mammalia Mlec 35
  • 88.47 (n)
  • 94.12 (a)
Mlec 16
Mlec 36
  • 95 (a)
(Pan troglodytes)
Mammalia MLEC 35
  • 99.66 (n)
  • 99.66 (a)
  • 99 (a)
(Rattus norvegicus)
Mammalia Mlec 35
  • 89.5 (n)
  • 95.16 (a)
(Ornithorhynchus anatinus)
Mammalia MLEC 36
  • 95 (a)
(Gallus gallus)
Aves MLEC 35
  • 79.76 (n)
  • 86.23 (a)
  • 80 (a)
(Anolis carolinensis)
Reptilia MLEC 36
  • 86 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia mlec 35
  • 79.27 (n)
  • 91.06 (a)
Str.6941 35
African clawed frog
(Xenopus laevis)
Amphibia kiaa0152-prov 35
(Danio rerio)
Actinopterygii mlec 35
  • 73.82 (n)
  • 82.59 (a)
mlec 36
  • 74 (a)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP007950 35
  • 57.92 (n)
  • 51.25 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG9257 35
  • 55.33 (n)
  • 48.58 (a)
CG9257 36
  • 36 (a)
(Caenorhabditis elegans)
Secernentea F44E2.10 35
  • 49.65 (n)
  • 37.66 (a)
F44E2.10 36
  • 31 (a)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.1179 35
sea squirt
(Ciona savignyi)
Ascidiacea CSA.8086 36
  • 46 (a)
Species with no ortholog for MLEC:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for MLEC Gene

Gene Tree for MLEC (if available)
Gene Tree for MLEC (if available)

Paralogs for MLEC Gene Pseudogenes for MLEC Gene

genes like me logo Genes that share paralogs with MLEC: view

No data available for Paralogs for MLEC Gene

Variants for MLEC Gene

Sequence variations from dbSNP and Humsavar for MLEC Gene

SNP ID Clin Chr 12 pos Sequence Context AA Info Type
rs2005455 -- 120,690,896(-) CACTA(C/T)TTGGA intron-variant, utr-variant-5-prime
rs10849778 -- 120,697,705(+) TGTCT(A/G)GTATC utr-variant-3-prime
rs504403 -- 120,695,234(+) CTGAT(C/G)ACTAT intron-variant
rs7306541 -- 120,692,243(+) AGTCG(A/G)TGTTC intron-variant, utr-variant-5-prime
rs34052093 -- 120,697,306(+) CTCAG(-/TTT)TTTTG utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for MLEC Gene

Variant ID Type Subtype PubMed ID
nsv521928 CNV Gain 19592680
nsv899557 CNV Loss 21882294
esv2659790 CNV Deletion 23128226

Variation tolerance for MLEC Gene

Residual Variation Intolerance Score: 37% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.29; 6.49% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for MLEC Gene

Disorders for MLEC Gene

Relevant External Links for MLEC

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for MLEC Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MLEC Gene

Publications for MLEC Gene

  1. Malectin forms a complex with ribophorin I for enhanced association with misfolded glycoproteins. (PMID: 22988243) Qin S.Y. … Yamamoto K. (J. Biol. Chem. 2012) 2 3 67
  2. Malectin: a novel carbohydrate-binding protein of the endoplasmic reticulum and a candidate player in the early steps of protein N-glycosylation. (PMID: 18524852) Schallus T. … Muhle-Goll C. (Mol. Biol. Cell 2008) 2 3
  3. Proteomic analysis and identification of cellular interactors of the giant ubiquitin ligase HERC2. (PMID: 25476789) Galligan J.T. … Howley P.M. (J. Proteome Res. 2015) 3
  4. Quantitative Proteomics Reveals Dynamic Interactions of the Minichromosome Maintenance Complex (MCM) in the Cellular Response to Etoposide Induced DNA Damage. (PMID: 25963833) Drissi R. … Boisvert F.M. (Mol. Cell Proteomics 2015) 3
  5. Panorama of ancient metazoan macromolecular complexes. (PMID: 26344197) Wan C. … Emili A. (Nature 2015) 3

Products for MLEC Gene

Sources for MLEC Gene