MLEC Gene
protein-coding GIFtS: 50
GCID: GC12P121124
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malectin(Previous name: KIAA0152 )
(Previous symbol: KIAA0152)
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Aliases
for MLEC gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Malectin1 | | KIAA01521 2 3 |
Export aliases for MLEC gene to outside databasesPrevious GC identifers: GC12P119611 GC12P118134 |
Summaries
for MLEC gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
UniProtKB/Swiss-Prot: MLEC_HUMAN, Q14165Function: Carbohydrate-binding protein with a strong ligand preference for Glc2-N-glycan. May play a role in the earlysteps of protein N-glycosylation (By similarity)
|
Genomic Views
for MLEC gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000012.11 NC_018923.1 NT_009775.17
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the MLEC gene promoter:
Elk-1 GATA-3 Brachyury XBP-1 LCR-F1 CBF-C CP1A CP1C Pax-4a NF-Y
Other transcription factors
Search SABiosciences Chromatin IP Primers for MLEC
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat MLEC |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 12q24.31 Ensembl cytogenetic band: 12q24.31 HGNC cytogenetic band: 12q24.31MLEC Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 12 GeneLoc Exon Structure GeneLoc location for GC12P121124: view genomic region
(about GC identifiers)
Start:
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121,124,672 bp from pter |
End:
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121,139,667 bp from pter |
Size:
|
14,996 bases |
Orientation:
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plus strand |
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Proteins
for MLEC gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: MLEC_HUMAN, Q14165 (See
protein sequence)Recommended Name: Malectin precursor Size: 292 amino acids; 32234 Da
Subcellular location: Endoplasmic reticulum membrane; Single-pass type I membrane protein (By similarity)
Sequence caution: Sequence=BAA09773.2; Type=Erroneous initiation;Explore the universe of human proteins at neXtProt for MLEC: NX_Q14165
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q14165
MLEC Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_055545.1
ENSEMBL proteins: ENSP00000228506 ENSP00000440746 ENSP00000438950 ENSP00000441247 Reactome Protein details: Q14165
Human Recombinant Protein Products for MLEC:
Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0005783 | endoplasmic reticulum |
ISS | -- | | GO:0005789 | endoplasmic reticulum membrane |
TAS | -- | | GO:0016021 | integral to membrane |
IEA | -- |
MLEC for ontologies About GeneDecksing
MLEC Antibody Products:
Assay Products for MLEC: |
Protein
Domains /
Families
for MLEC gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
MLEC for domains About GeneDecksing
1 InterPro domain/family:Graphical View of Domain Structure for InterPro Entry Q14165ProtoNet protein and cluster: Q14165 UniProtKB/Swiss-Prot: MLEC_HUMAN, Q14165Similarity: Belongs to the malectin family |
Function
for MLEC gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
inGenious Targeting Laboratory,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase,
shRNA from
OriGene,
Sirion Biotech,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Sirion Biotech,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
Sirion Biotech,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Molecular Function:
UniProtKB/Swiss-Prot Summary: MLEC_HUMAN, Q14165Function: Carbohydrate-binding protein with a strong ligand preference for Glc2-N-glycan. May play a role in the earlysteps of protein N-glycosylation (By similarity) Gene Ontology (GO): 1 molecular function term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0030246 | carbohydrate binding |
ISS | -- |
MLEC for ontologies About GeneDecksing
Animal Models:
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for MLEC (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for MLEC
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: MLEC (NM_014730) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for MLEC | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MLEC |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MLEC |
|
Pathways & Interactions
for MLEC gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Unified GeneCards pathways About this table
See pathways by source
| Super-pathway | contained gene-specific pathways |
|---|
| 1 | Asparagine N-linked glycosylation | | | 2 | Calnexin/calreticulin cycle | |
Pathway sources
See GeneCards unified pathways
Show all pathways
4 
Reactome Pathways for MLEC
MLEC for pathways About GeneDecksing
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for MLEC
STRING Interaction
Network Preview (showing 5 interactants - click image to see more details)
5/11 Interacting proteins for MLEC (Q141653 ENSP000002285064) via UniProtKB, MINT, STRING, and/or I2D (see all 11)About this table
Gene Ontology (GO): 4 biological process terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0006457 | protein folding |
TAS | -- | | GO:0018279 | protein N-linked glycosylation via asparagine |
TAS | -- | | GO:0043687 | post-translational protein modification |
TAS | -- | | GO:0044267 | cellular protein metabolic process |
TAS | -- |
MLEC for ontologies About GeneDecksing
|
Drugs & Compounds
for MLEC gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for MLEC
Search CenterWatch for drugs/clinical trials and news about MLEC
|
Transcripts
for MLEC gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
Sirion Biotech,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for MLEC gene: NM_014730.2 Unigene Cluster for MLEC: Malectin Hs.507074 [show with all ESTs]Unigene Representative Sequence: NM_0147305 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000228506(uc001tyy.1) ENST00000412616 ENST00000545525 ENST00000535656
ENST00000535413
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for MLEC (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for MLEC
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: MLEC (NM_014730) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for MLEC | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MLEC |
Additional cDNA sequence: BC000371.2 BC016297.2 CR936818.1 D63486.1 U88835.1 24/26 DOTS entries (see all 26): DT.100833228 DT.100833225 DT.449134 DT.91984978 DT.121201239 DT.100833229 DT.70105435 DT.100833231 DT.91893123 DT.95374785 DT.100833221 DT.100833233 DT.100833236 DT.40118196 DT.99945781 DT.100762980 DT.100833223 DT.100833227 DT.121201257 DT.121201262 DT.91798998 DT.91998365 DT.97808550 DT.101973696 24/786 AceView cDNA sequences (see all 786): BQ682130 CB149511 AI299852 CB145034 BQ879070 BU737578 AI802576 AA226950 AU132350 BX956718 BQ181382 AI286267 AI365562 BM699760 AA772307 BU625986 BQ687534 BQ928452 BP338333 BU177187 CA448214 Z42751 CF552326 BC000371
GeneLoc Exon Structure
5 Alternative Splicing Database (ASD) splice patterns (SP) for MLEC About this scheme
| ExUns: | 1 | ^ | 2 | ^ | 3a | · | 3b | ^ | 4 | ^ | 5 | ^ | 6 | ^ | 7a | · | 7b | · | 7c | ^ | 8a | · | 8b |
|---|
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| SP1: | | | - | | | | | | | | | | | | | | | | | | | | | | |
| SP2: | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP3: | | | | | | | | | | | - | | | | | | | | | | | | | | |
| SP4: | | | | | | | | | | | | | | | | | | | - | | | | | | |
| SP5: | | | | | | | | | | | | | | | | | | | - | | | | | |
ECgene alternative splicing isoforms for MLEC
|
Expression
for MLEC gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| MLEC expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: TTTCCCATCC
About this image
See MLEC Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for MLEC
SOURCE GeneReport for Unigene cluster: Hs.507074
SABiosciences Custom PCR Arrays for MLEC
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for MLEC
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat MLEC | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat MLEC | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat MLEC | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MLEC |
Orthologs
for MLEC gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of animals.
Orthologs for MLEC gene from 7/21 species (see all 21) About this table
ENSEMBL Gene Tree for MLEC (if available)
TreeFam Gene Tree for MLEC (if available) |
Paralogs
for MLEC gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for MLEC gene
MLEC for paralogs About GeneDecksing
1 Pseudogenes.org Pseudogene for MLEC
PGOHUM00000259280
|
Genomic Variants
for MLEC gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
| | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing MLEC |
|
Disorders
/ Diseases
for MLEC gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
MLEC for disorders About GeneDecksing
OMIM gene information: 613802
OMIM disorders: --
2  diseases for MLEC: About MalaCardsleprosy schizophrenia
1 disease from the University of Copenhagen DISEASES database for MLEC:Leprosy Human Genome Epidemiology (HuGE) Navigator: MLEC (2 documents)
Export disorders for MLEC gene to outside databases
|
Publications
for MLEC gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for MLEC gene, integrated from 9 sources (see all 15):
(articles sorted by number of sources associating them with MLEC) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Malectin: a novel carbohydrate-binding protein of the endoplasmic reticulum and a candidate player in the early steps of protein N-glycosylation. (PubMed id 18524852)1, 3 Schallus T....Muhle-Goll C. (2008)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- Prediction of the coding sequences of unidentified human genes. IV. The coding sequences of 40 new genes (KIAA0121-KIAA0160) deduced by analysis of cDNA clones from human cell line KG-1. (PubMed id 8590280)1, 2 Nagase T....Nomura N. (1995)
- A census of human soluble protein complexes. (PubMed id 22939629)1 Havugimana P.C....Emili A. (2012)
- Malectin forms a complex with ribophorin I for enhance d association with misfolded glycoproteins. (PubMed id 22988243)1 Qin S.Y....Yamamoto K. (2012)
- Systematic and quantitative assessment of the ubiquiti n-modified proteome. (PubMed id 21906983)1 Kim W....Gygi S.P. (2011)
- Role of malectin in Glc(2)Man(9)GlcNAc(2)-dependent q uality control of I+1-antitrypsin. (PubMed id 21813736)1 Chen Y....Yamamoto K. (2011)
- Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (2011)
- Mass spectrometric analysis of lysine ubiquitylation r eveals promiscuity at site level. (PubMed id 21139048)1 Danielsen J.M....Nielsen M.L. (2011)
- MicroRNAs and target site screening reveals a pre-mic roRNA-30e variant associated with schizophrenia. (PubMed id 20347265)1 Xu Y....Liu P. (2010)
|
External Searches for MLEC gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing MLEC gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing MLEC gene
(According to HUGE)
About This Section
| |
Specialized Databases showing MLEC gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for MLEC | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for MLEC gene:
Search GeneIP for patents involving MLEC
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for MLEC gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, LifeMap BioReagents, and Sirion Biotech, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory)
About This Section
|
 | |
 | |
 |
| | |  | OriGene Antibodies for MLEC | | Browse OriGene shRNA RFPs | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for MLEC | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for MLEC | | | OriGene Protein Over-expression Lysate for MLEC | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for MLEC | | OriGene 3'-UTR Clone for MLEC | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for MLEC | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for MLEC | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for MLEC | | OriGene Custom Protein Services for MLEC | | | OriGene Custom Immunoassay Development | | |
| |
 |
 |
| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat MLEC | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing MLEC | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat MLEC | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat MLEC | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat MLEC | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat MLEC |
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 |  |  |  | |
| | | | Search Tocris compounds for MLEC |
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 | | | MLEC Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MLEC |
|  |  |  |  | | | | ThermoFisher Antibodies for MLEC |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MLEC |
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