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Aliases for MLEC Gene

Aliases for MLEC Gene

  • Malectin 2 3 3 5
  • KIAA0152 2 3 4
  • Oligosaccharyltransferase Complex Subunit (Non-Catalytic) 2 3

External Ids for MLEC Gene

Previous HGNC Symbols for MLEC Gene

  • KIAA0152

Previous GeneCards Identifiers for MLEC Gene

  • GC12P119611
  • GC12P121124
  • GC12P118134

Summaries for MLEC Gene

Entrez Gene Summary for MLEC Gene

  • This gene encodes the carbohydrate-binding protein malectin which is a Type I membrane-anchored endoplasmic reticulum protein. This protein has an affinity for Glc2Man9GlcNAc2 (G2M9) N-glycans and is involved in regulating glycosylation in the endoplasmic reticulum. This protein has also been shown to interact with ribophorin I and may be involved in the directing the degradation of misfolded proteins. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Jan 2015]

GeneCards Summary for MLEC Gene

MLEC (Malectin) is a Protein Coding gene. Among its related pathways are Innate Immune System and Transport to the Golgi and subsequent modification. GO annotations related to this gene include enzyme binding and carbohydrate binding.

UniProtKB/Swiss-Prot for MLEC Gene

  • Carbohydrate-binding protein with a strong ligand preference for Glc2-N-glycan. May play a role in the early steps of protein N-glycosylation (By similarity).

No data available for CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MLEC Gene

Genomics for MLEC Gene

Regulatory Elements for MLEC Gene

Enhancers for MLEC Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH12G120683 1.4 ENCODE dbSUPER 13.7 +0.6 579 7.3 CREB3L1 ZFP64 FEZF1 DMAP1 YBX1 YY1 SLC30A9 ZNF143 SP3 NFYC GCN1 ACADS ANAPC5 C12orf43 MLEC ENSG00000256569 RPL31P52 ENSG00000255946 UNC119B COQ5
GH12G120958 1.6 Ensembl ENCODE dbSUPER 10.4 +274.2 274205 5.5 HDGF PKNOX1 ARNT CREB3L1 MLX AGO1 ARID4B SIN3A DMAP1 ZNF2 ACADS C12orf43 SPPL3 OASL ENSG00000256569 ENSG00000255946 UNC119B MLEC ENSG00000256364 P2RX4
GH12G120709 1.2 ENCODE dbSUPER 11.7 +23.8 23761 2.7 PKNOX1 AGO1 ZNF493 ZFP64 ARID4B SIN3A YY1 GLIS2 ZNF766 SP3 GCN1 ANAPC5 RPL31P52 ACADS C12orf43 MLEC SPPL3 UNC119B PIR48112
GH12G120583 1.2 Ensembl ENCODE 11.2 -102.7 -102666 2.0 ARID4B GLIS2 ZNF143 ZNF263 REST ZNF579 GLIS1 MXD3 KDM1A HNF4A COQ5 GATC HNF1A-AS1 MLEC UNC119B C12orf43 ENSG00000256569 ACADS OASL DYNLL1
GH12G120580 1.1 ENCODE 11.2 -105.5 -105476 1.9 HDGF PKNOX1 AGO1 WRNIP1 ARID4B SIN3A DMAP1 ZNF2 YY1 ZNF766 COQ5 GATC HNF1A-AS1 MLEC UNC119B C12orf43 ACADS ENSG00000256569 OASL SRSF9
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around MLEC on UCSC Golden Path with GeneCards custom track

Promoters for MLEC Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000058344 731 3201 CREB3L1 ZFP64 DMAP1 YBX1 YY1 SLC30A9 ZNF143 SP3 NFYC TBX21

Genomic Location for MLEC Gene

Chromosome:
12
Start:
120,686,869 bp from pter
End:
120,701,864 bp from pter
Size:
14,996 bases
Orientation:
Plus strand

Genomic View for MLEC Gene

Genes around MLEC on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MLEC Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MLEC Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MLEC Gene

Proteins for MLEC Gene

  • Protein details for MLEC Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q14165-MLEC_HUMAN
    Recommended name:
    Malectin
    Protein Accession:
    Q14165

    Protein attributes for MLEC Gene

    Size:
    292 amino acids
    Molecular mass:
    32234 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=BAA09773.2; Type=Erroneous initiation; Evidence={ECO:0000305};

neXtProt entry for MLEC Gene

Post-translational modifications for MLEC Gene

  • Glycosylation at Asn268
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for MLEC Gene

Domains & Families for MLEC Gene

Gene Families for MLEC Gene

Protein Domains for MLEC Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for MLEC Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q14165

UniProtKB/Swiss-Prot:

MLEC_HUMAN :
  • Belongs to the malectin family.
Family:
  • Belongs to the malectin family.
genes like me logo Genes that share domains with MLEC: view

Function for MLEC Gene

Molecular function for MLEC Gene

UniProtKB/Swiss-Prot Function:
Carbohydrate-binding protein with a strong ligand preference for Glc2-N-glycan. May play a role in the early steps of protein N-glycosylation (By similarity).

Gene Ontology (GO) - Molecular Function for MLEC Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0019899 enzyme binding IPI 22988243
GO:0030246 carbohydrate binding ISS --
genes like me logo Genes that share ontologies with MLEC: view
genes like me logo Genes that share phenotypes with MLEC: view

Animal Models for MLEC Gene

MGI Knock Outs for MLEC:
  • Mlec tm1a(EUCOMM)Wtsi

Animal Model Products

CRISPR Products

miRNA for MLEC Gene

miRTarBase miRNAs that target MLEC

Inhibitory RNA Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for MLEC Gene

Localization for MLEC Gene

Subcellular locations from UniProtKB/Swiss-Prot for MLEC Gene

Endoplasmic reticulum membrane; Single-pass type I membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for MLEC gene
Compartment Confidence
plasma membrane 5
endoplasmic reticulum 5
extracellular 1

Gene Ontology (GO) - Cellular Components for MLEC Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005783 endoplasmic reticulum ISS --
GO:0005789 endoplasmic reticulum membrane TAS --
GO:0005886 plasma membrane TAS --
GO:0016020 membrane IEA,IDA 19946888
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with MLEC: view

Pathways & Interactions for MLEC Gene

genes like me logo Genes that share pathways with MLEC: view

Interacting Proteins for MLEC Gene

Gene Ontology (GO) - Biological Process for MLEC Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005975 carbohydrate metabolic process IEA --
GO:0006457 protein folding TAS --
GO:0043312 neutrophil degranulation TAS --
genes like me logo Genes that share ontologies with MLEC: view

No data available for SIGNOR curated interactions for MLEC Gene

Drugs & Compounds for MLEC Gene

No Compound Related Data Available

Transcripts for MLEC Gene

Unigene Clusters for MLEC Gene

Malectin:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for MLEC Gene

ExUns: 1 ^ 2 ^ 3a · 3b ^ 4 ^ 5 ^ 6 ^ 7a · 7b · 7c ^ 8a · 8b
SP1: -
SP2:
SP3: -
SP4: -
SP5: -

Relevant External Links for MLEC Gene

GeneLoc Exon Structure for
MLEC
ECgene alternative splicing isoforms for
MLEC

Expression for MLEC Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for MLEC Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for MLEC Gene

This gene is overexpressed in Peripheral blood mononuclear cells (7.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for MLEC Gene



Protein tissue co-expression partners for MLEC Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of MLEC Gene:

MLEC

SOURCE GeneReport for Unigene cluster for MLEC Gene:

Hs.744910

Evidence on tissue expression from TISSUES for MLEC Gene

  • Lung(4.8)
  • Skin(4.8)
  • Liver(4.5)
  • Bone marrow(4.2)
  • Nervous system(4.2)
  • Intestine(4)
  • Kidney(3.2)
  • Eye(2.7)
  • Heart(2.3)
  • Pancreas(2.2)
genes like me logo Genes that share expression patterns with MLEC: view

Primer Products

No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for MLEC Gene

Orthologs for MLEC Gene

This gene was present in the common ancestor of animals.

Orthologs for MLEC Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia MLEC 34 35
  • 99.66 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia MLEC 35
  • 95 (a)
OneToOne
dog
(Canis familiaris)
Mammalia MLEC 34 35
  • 94.93 (n)
cow
(Bos Taurus)
Mammalia MLEC 34 35
  • 90.22 (n)
rat
(Rattus norvegicus)
Mammalia Mlec 34
  • 89.5 (n)
mouse
(Mus musculus)
Mammalia Mlec 34 16 35
  • 88.47 (n)
chicken
(Gallus gallus)
Aves MLEC 34 35
  • 79.76 (n)
lizard
(Anolis carolinensis)
Reptilia MLEC 35
  • 86 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia mlec 34
  • 79.27 (n)
Str.6941 34
African clawed frog
(Xenopus laevis)
Amphibia kiaa0152-prov 34
zebrafish
(Danio rerio)
Actinopterygii mlec 34 35
  • 73.82 (n)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP007950 34
  • 57.92 (n)
fruit fly
(Drosophila melanogaster)
Insecta CG9257 34 35
  • 55.33 (n)
worm
(Caenorhabditis elegans)
Secernentea F44E2.10 34 35
  • 49.65 (n)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.8086 35
  • 46 (a)
OneToOne
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.1179 34
Species where no ortholog for MLEC was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for MLEC Gene

ENSEMBL:
Gene Tree for MLEC (if available)
TreeFam:
Gene Tree for MLEC (if available)

Paralogs for MLEC Gene

Pseudogenes.org Pseudogenes for MLEC Gene

genes like me logo Genes that share paralogs with MLEC: view

No data available for Paralogs for MLEC Gene

Variants for MLEC Gene

Sequence variations from dbSNP and Humsavar for MLEC Gene

SNP ID Clin Chr 12 pos Sequence Context AA Info Type
rs1000066995 -- 120,691,916(+) GCACT(C/T)TGGGA intron-variant, utr-variant-5-prime
rs1000293643 -- 120,691,532(+) CTTTT(C/T)GGTTA intron-variant, utr-variant-5-prime
rs1000317612 -- 120,699,049(+) AACTT(C/G)AAAGT utr-variant-3-prime
rs1000586845 -- 120,696,798(+) GGATA(C/T)TTAGG utr-variant-3-prime
rs1000663938 -- 120,691,287(+) CTCTC(C/T)GTGTG intron-variant, utr-variant-5-prime

Structural Variations from Database of Genomic Variants (DGV) for MLEC Gene

Variant ID Type Subtype PubMed ID
esv2659790 CNV deletion 23128226
esv3630929 CNV loss 21293372
nsv1045923 CNV gain 25217958
nsv521928 CNV gain 19592680

Variation tolerance for MLEC Gene

Residual Variation Intolerance Score: 37% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.29; 6.49% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for MLEC Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MLEC

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MLEC Gene

Disorders for MLEC Gene

Relevant External Links for MLEC

Genetic Association Database (GAD)
MLEC
Human Genome Epidemiology (HuGE) Navigator
MLEC
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
MLEC

No disorders were found for MLEC Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MLEC Gene

Publications for MLEC Gene

  1. Malectin forms a complex with ribophorin I for enhanced association with misfolded glycoproteins. (PMID: 22988243) Qin S.Y. … Yamamoto K. (J. Biol. Chem. 2012) 2 3 64
  2. MicroRNAs and target site screening reveals a pre-microRNA-30e variant associated with schizophrenia. (PMID: 20347265) Xu Y. … Liu P. (Schizophr. Res. 2010) 3 46 64
  3. Malectin: a novel carbohydrate-binding protein of the endoplasmic reticulum and a candidate player in the early steps of protein N-glycosylation. (PMID: 18524852) Schallus T. … Muhle-Goll C. (Mol. Biol. Cell 2008) 2 3 64
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
  5. Prediction of the coding sequences of unidentified human genes. IV. The coding sequences of 40 new genes (KIAA0121-KIAA0160) deduced by analysis of cDNA clones from human cell line KG-1. (PMID: 8590280) Nagase T. … Nomura N. (DNA Res. 1995) 3 4 64

Products for MLEC Gene

Sources for MLEC Gene

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