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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

MLANA Gene

protein-coding   GIFtS: 54
GCID: GC09P005846

melan-A
 Explore 49 diseases affiliated with
MLANA via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for MLANA    

Aliases
for MLANA gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
Melan-A1     Protein Melan-A2 3
MART11 2 3 5     MART-12 3
Antigen LB39-AA2 3     Melanoma Antigen Recognized By T-Cells 12
Antigen SK29-AA2 3     

External Ids:    HGNC: 71241   Entrez Gene: 23152   Ensembl: ENSG000001202157   OMIM: 6055135   UniProtKB: Q166553   

Export aliases for MLANA gene to outside databases

Previous GC identifers: GC09P006044 GC09P005872 GC09P005880 GC09P005892


Summaries
for MLANA gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
UniProtKB/Swiss-Prot: MAR1_HUMAN, Q16655
Function: Involved in melanosome biogenesis by ensuring the stability of GPR143. Plays a vital role in the expression,
stability, trafficking, and processing of melanocyte protein PMEL, which is critical to the formation of stage II
melanosomes

Gene Wiki entry for MLANA


Genomic Views
for MLANA gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000009.11  NC_018920.1  NT_008413.18  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the MLANA gene promoter:
         C/EBPbeta   p53   CUTL1   AP-4   AREB6   GATA-6   POU2F1   POU2F1a   Chx10   TGIF   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: MLANA promoter sequence
   Search SABiosciences Chromatin IP Primers for MLANA

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat MLANA


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 9p24.1   Ensembl cytogenetic band:  9p24.1   HGNC cytogenetic band: 9p24.1

MLANA Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
MLANA gene location

GeneLoc information about chromosome 9         GeneLoc Exon Structure

GeneLoc location for GC09P005846:  view genomic region     (about GC identifiers)

Start:
 5,890,802 bp from pter      End:
 5,910,606 bp from pter
Size:
 19,805 bases      Orientation:
 plus strand

Proteins
for MLANA gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: MAR1_HUMAN, Q16655 (See protein sequence)
Recommended Name: Melanoma antigen recognized by T-cells 1  
Size: 118 amino acids; 13157 Da
Subunit: Interacts with PMEL. Interacts with GPR143
Subcellular location: Endoplasmic reticulum membrane; Single-pass type III membrane protein. Golgi apparatus. Golgi
apparatus, trans-Golgi network membrane. Melanosome. Note=Also found in small vesicles and tubules dispersed over the
entire cytoplasm. A small fraction of the protein is inserted into the membrane in an inverted orientation. Inversion
of membrane topology results in the relocalization of the protein from a predominant Golgi/post-Golgi area to the
endoplasmic reticulum. Melanoma cells expressing the protein with an inverted membrane topology are more effectively
recognized by specific cytolytic T-lymphocytes than those expressing the protein in its native membrane orientation
6/8 PDB 3D structures from and Proteopedia for MLANA (see all 8):
2GT9 (3D)        2GTW (3D)        2GTZ (3D)        2GUO (3D)        3L6F (3D)        3MRO (3D)    
Secondary accessions: Q6ICU4

Explore the universe of human proteins at neXtProt for MLANA: NX_Q16655

Post-translational modifications:

  • Acylated1
  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q16655

    • MLANA Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins: NP_005502.1  
    ENSEMBL proteins: 
     ENSP00000370886   ENSP00000370885   ENSP00000370880  

    Human Recombinant Protein Products: 
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    Novus Biologicals MLANA Proteins
    Browse Sino Biological Recombinant Proteins
    Browse ProSpec Recombinant Proteins
    Uscn Proteins for MLANA

    Gene Ontology (GO): 5 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005789endoplasmic reticulum membrane IDA15695812
    GO:0005794Golgi apparatus IDA15695812
    GO:0005802trans-Golgi network IDA12191019
    GO:0005887integral to plasma membrane TAS8170938
    GO:0042470melanosome IDA15695812


    MLANA for ontologies           About GeneDecksing



    MLANA Antibody Products: 
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    ThermoFisher Antibody for MLANA

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    Uscn ELISAs and CLIAs for MLANA

    Protein Domains /
    Families
    for MLANA gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    ProtoNet protein and cluster: Q16655


    Function
    for MLANA gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: MAR1_HUMAN, Q16655
    Function: Involved in melanosome biogenesis by ensuring the stability of GPR143. Plays a vital role in the expression,
    stability, trafficking, and processing of melanocyte protein PMEL, which is critical to the formation of stage II
    melanosomes

    miRNA
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    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat MLANA
    8/12 QIAGEN miScript miRNA Assays for microRNAs that regulate MLANA (see all 12):
    hsa-miR-21* hsa-miR-203 hsa-miR-1206 hsa-miR-548p hsa-miR-595 hsa-miR-1266 hsa-miR-3616-5p hsa-miR-3647-5p
    SwitchGear 3'UTR luciferase reporter plasmid: MLANA 3' UTR sequence
    Inhib. RNA
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    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for MLANA (see all 7)
    OriGene shRNA RFP: MLANA
    OriGene siRNA: MLANA
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat MLANA

    Gene Editing
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    Clone
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    Cell Line
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    Search LifeMap BioReagents cell lines for MLANA

    In Situ Assay
    Products:       
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MLANA

    Gene Ontology (GO): 1 molecular function term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding IPI15695812


    MLANA for ontologies           About GeneDecksing



    Pathways & Interactions
    for MLANA gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section



    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for MLANA

    STRING Interaction Network Preview (showing 4 interactants - click image to see more details)

    4 Interacting proteins for MLANA (Q166552, 3 ENSP000003708804) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ITCHQ96J022, 3, ENSP000003639984MINT-7889653 I2D: score=2 STRING: ENSP00000363998
    NEDD4P469342, 3, ENSP000003455304MINT-7889653 I2D: score=2 STRING: ENSP00000345530
    GPR143P518103, ENSP000003703164I2D: score=1 STRING: ENSP00000370316
    UBCP0CG483, ENSP000003448184I2D: score=1 STRING: ENSP00000344818
    About this table

    Drugs & Compounds
    for MLANA gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    MLANA for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for MLANA
    4 Novoseek chemical compound relationships for MLANA gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    paraffin 37.8 3 16405409 (1), 19667333 (1), 15113392 (1)
    hematoxylin 29.1 2 12960803 (1), 16405409 (1)
    steroid 0 1 9422316 (1)
    lactate 0 1 16179868 (1)

    Search CenterWatch for drugs/clinical trials and news about MLANA / MAR1 

    Transcripts
    for MLANA gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for MLANA gene: 
    NM_005511.1  

    Unigene Cluster for MLANA:

    Melan-A
    Hs.154069  [show with all ESTs]
    Unigene Representative Sequence: NM_005511
    5 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000381477(uc003zjo.1) ENST00000381476 ENST00000381471 ENST00000482341
    ENST00000490518

    miRNA
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    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat MLANA
    8/12 QIAGEN miScript miRNA Assays for microRNAs that regulate MLANA (see all 12):
    hsa-miR-21* hsa-miR-203 hsa-miR-1206 hsa-miR-548p hsa-miR-595 hsa-miR-1266 hsa-miR-3616-5p hsa-miR-3647-5p
    SwitchGear 3'UTR luciferase reporter plasmid: MLANA 3' UTR sequence
    Inhib. RNA
    Products:             		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for MLANA (see all 7)
    OriGene shRNA RFP: MLANA
    OriGene siRNA: MLANA
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat MLANA
    Clone
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    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for MLANA
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    GenScript: all cDNA clones in your preferred vector: MLANA (NM_005511)
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    Primer
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      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat MLANA
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat MLANA

    Additional cDNA sequence: 

    AK312149.1 BC014423.1 CR450299.1 U06452.1 U06654.1 

    8 DOTS entries:

    DT.114514  DT.441148  DT.92431925  DT.95259238  DT.95159375  DT.100685191  DT.91993863  DT.95159374 

    24/142 AceView cDNA sequences (see all 142):

    BU189774 CR623651 BU195377 BM663875 BI758036 N24796 AA233891 BC014423 
    NM_005511 BQ677646 U06452 BU155807 N26562 BQ435119 BQ678597 BU726393 
    BM705061 BQ677630 AI433774 BX444322 BU165857 BX423914 CR450299 CR613373 

    GeneLoc Exon Structure

    5 Alternative Splicing Database (ASD) splice patterns (SP) for MLANA    About this scheme

    ExUns: 1a · 1b ^ 2a · 2b ^ 3a · 3b ^ 4 ^ 5a · 5b ^ 6a · 6b · 6c
    SP1:              -     -                             -                     
    SP2:                                                  -                     
    SP3:                    -                             -                     
    SP4:                                      -           -                     
    SP5:                                                                        


    ECgene alternative splicing isoforms for MLANA

    Expression
    for MLANA gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    MLANA expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: TGAGGAAATG

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image

    MLANA expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
    2 LifeMap In Vivo Development Anatomical Compartments/Cells 
    Tissue Anatomical Compartment CellCategory (developmental path)
    EyeRetinal Pigmented EpitheliumMature Retinal Pigmented Epithelium CellsRetinal Pigmented Epithelium
    EyeRetinal Pigmented EpitheliumRetinal Pigmented Epithelium Progenitor CellsRetinal Pigmented Epithelium
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization

    See MLANA Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for MLANA

    SOURCE GeneReport for Unigene cluster: Hs.154069

    UniProtKB/Swiss-Prot: MAR1_HUMAN, Q16655
    Tissue specificity: Expression is restricted to melanoma and melanocyte cell lines and retina

        SABiosciences Custom PCR Arrays for MLANA
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    In Situ
    Assay Products:     
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    Orthologs
    for MLANA gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of chordates.

    Orthologs for MLANA gene from 3/8 species (see all 8)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    mouse
    (Mus musculus)    		 Mammalia Mlana1 , 5 melan-A1, 5 77.58(n)1
    71.68(a)1    		   19 (24.28 cM)5
    778361  NM_029993.11  NP_084269.11 
     296979415 
    chicken
    (Gallus gallus)    		 Aves MLANA1 melan-A 60.71(n)
    51.79(a)    		   769648  XM_001232042.2  XP_001232043.1 
    lizard
    (Anolis carolinensis)    		 Reptilia MLANA6
    		 --
    		 46(a)
    		 1 ↔ 1
    		 2(52511232-52516853)


    ENSEMBL Gene Tree for MLANA (if available)
    TreeFam Gene Tree for MLANA (if available) 

    Paralogs
    for MLANA gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    		  --

    Genomic Variants
    for MLANA gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/363 NCBI SNPs in MLANA are shown (see all 363)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 9 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs733953571,2
    		C,F,--5888971(+) AGTGGC/TTGGTC 1 -- us2k15Minor allele frequency- T:0.20WA NA 244
    rs1155968121,2
    		F,--5889015(+) AACTTG/CCACCG 1 -- us2k11Minor allele frequency- C:0.08WA 118
    rs1927477341,2
    		--5889068(+) ATCCAC/TTACAT 1 -- us2k10--------
    rs64770181,2
    		C,F,A,--5889099(+) CCATTA/GTATCT 1 -- us2k17Minor allele frequency- G:0.13NA WA EA 366
    rs1844911271,2
    		--5889137(+) TTGCAC/TCGAAT 1 -- us2k10--------
    rs751859131,2
    		C,--5889205(+) CACCTA/GACCAC 1 -- us2k12Minor allele frequency- G:0.03WA 120
    rs1170135801,2
    		F,--5889210(+) AACCAC/AATGTC 1 -- us2k11Minor allele frequency- A:0.02EA 120
    rs1467621101,2
    		--5889405(+) TGAAGC/TATGAA 1 -- us2k10--------
    rs586416351,2
    		C--5889561(+) GCAGGC/TGGATC 1 -- us2k11Minor allele frequency- T:0.50WA 2
    rs1878133751,2
    		--5889590(+) GACCAC/TCCTGG 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for MLANA (5890802 - 5910606 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
          Database of Genomic Variants (DGV) variations for MLANA: --

    SABiosciences Cancer Mutation PCR Assays
    QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing MLANA
    DNA2.0 Custom Variant and Variant Library Synthesis for MLANA

    Disorders / Diseases
    for MLANA gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    MLANA for disorders           About GeneDecksing

    OMIM gene information: 605513    OMIM disorders: --

    20/49 diseases for MLANA (see all 49):    About MalaCards
    melanoma    lentigo maligna melanoma    sertoli-leydig cell tumor    juvenile xanthogranuloma
    superficial spreading melanoma    perivascular epithelioid cell tumor    posterior uveal melanoma    meningeal melanocytoma
    granular cell tumor    lichen sclerosus    nevus    mycosis fungoides
    retroperitoneal sarcoma    ocular albinism    leydig cell tumor    cutaneous malignant melanoma
    sertoli cell tumor    clear cell sarcoma    angiomyolipoma    testicular cancer

    10 diseases from the University of Copenhagen DISEASES database for MLANA:
    Melanoma     Perivascular epithelioid cell tumor     Angiomyolipoma     Microphthalmia
    Vitiligo     Lymphangioleiomyomatosis     Sarcoma     Skin cancer
    Leiomyosarcoma     Influenza

    10/26 Novoseek disease relationships for MLANA gene (see all 26)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    melanoma 86.5 199 12735792 (5), 12472287 (4), 11169510 (4), 10360670 (3) (see all 99)
    metastatic melanoma 84.5 10 17414440 (1), 10803712 (1), 12843797 (1), 11511319 (1) (see all 9)
    microphthalmia 71.5 14 11145253 (5), 12472287 (1), 11803278 (1), 15731577 (1) (see all 9)
    stage iii melanoma 70.9 1 12829676 (1)
    nevi melanocytic 70.6 6 10871066 (3), 10688724 (2), 9706977 (1)
    nevi 68.1 9 20142539 (2), 9706977 (2), 15141316 (1), 11493377 (1) (see all 6)
    vitiligo 64.1 9 11979069 (3), 16778827 (1), 16260696 (1), 9672845 (1) (see all 6)
    tumors 57.5 54 12649671 (3), 11145253 (2), 10688724 (2), 12472287 (1) (see all 43)
    angiomyolipoma 57.1 11 11145253 (4), 10389626 (2), 11914628 (2), 17227112 (1)
    granular cell tumor 52.4 1 17284958 (1)

    Human Genome Epidemiology (HuGE) Navigator: MLANA (1 document)

    Export disorders for MLANA gene to outside databases

    Publications
    for MLANA gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for MLANA gene, integrated from 9 sources (see all 253):
    (articles sorted by number of sources associating them with MLANA)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. Cloning of the gene coding for a shared human melanoma antigen recognized by autologous T cells infiltrating into tumor. (PubMed id 8170938)1, 2, 9 Kawakami Y.... Rosenberg S.A. (1994)
    2. Structural basis for the presentation of tumor-associ ated MHC class II-restricted phosphopeptides to CD4+ T cells. (PubMed id 20417641)1, 2 Li Y....Mariuzza R.A. (2010)
    3. The ocular albinism type 1 (OA1) G-protein-coupled re ceptor functions with MART-1 at early stages of melanogenesis to control melano some identity and composition. (PubMed id 19717472)1, 2 Giordano F....Raposo G. (2009)
    4. MART-1 is required for the function of the melanosomal matrix protein PMEL17/GP100 and the maturation of melanosomes. (PubMed id 15695812)1, 2 Hoashi T....Hearing V.J. (2005)
    5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    6. The melanocytic protein Melan-A/MART-1 has a subcellular localization distinct from typical melanosomal proteins. (PubMed id 12191019)1, 2 De Maziere A.M.... Rimoldi D. (2002)
    7. A new gene coding for a differentiation antigen recognized by autologous cytolytic T lymphocytes on HLA-A2 melanomas. (PubMed id 8006593)1, 2 Coulie P.G.... Boon T. (1994)
    8. Differential expression of melanocytic markers in myoid, lipomatous, and vascular components of renal angiomyolipomas. (PubMed id 17227112)1, 9 Roma A.A....Zhou M. (2007)
    9. Expression of Melan-A/MART-1 in primary melanoma cell cultures has prognostic implication in metastatic melanoma patients. (PubMed id 15305155)1, 9 Murer K....Dummer R. (2004)
    10. MLANA/MART1 and SILV/PMEL17/GP100 are transcriptionally regulated by MITF in melanocytes and melanoma. (PubMed id 12819038)1, 9 Du J....Fisher D.E. (2003)

    External Searches for MLANA gene

    (in PubMed, OMIM, and NCBI Bookshelf)
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    Genome Databases showing MLANA gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 2315 HGNC: 7124 AceView: MLANA Ensembl:ENSG00000120215 euGenes: HUgn2315
    ECgene: MLANA H-InvDB: MLANA

    Other Databases showing MLANA gene

    (According to HUGE)
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    Specialized Databases showing MLANA gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for MLANA Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for MLANA Genetics and Cytogenetics in Oncology and Haematology

    Intellectual Property
    for MLANA gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for MLANA gene:
    Search GeneIP for patents involving MLANA

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