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MLANA Gene

protein-coding   GIFtS: 56
GCID: GC09P005846

Melan-A

  See MLANA-related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
melan-A1 2     Protein Melan-A2 3
MART12 3 5     MART-12 3
Antigen LB39-AA2 3     Melanoma Antigen Recognized By T-Cells 12
Antigen SK29-AA2 3     

External Ids:    HGNC: 71241   Entrez Gene: 23152   Ensembl: ENSG000001202157   OMIM: 6055135   UniProtKB: Q166553   

Export aliases for MLANA gene to outside databases

Previous GC identifers: GC09P006044 GC09P005872 GC09P005880 GC09P005892


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for MLANA Gene:
MLANA (melan-A) is a protein-coding gene. Diseases associated with MLANA include halo nevi, and juvenile xanthogranuloma.

UniProtKB/Swiss-Prot: MAR1_HUMAN, Q16655
Function: Involved in melanosome biogenesis by ensuring the stability of GPR143. Plays a vital role in the
expression, stability, trafficking, and processing of melanocyte protein PMEL, which is critical to the formation
of stage II melanosomes

Gene Wiki entry for MLANA Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000009.11  NT_008413.19  NC_018920.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the MLANA gene promoter:
         C/EBPbeta   p53   CUTL1   AP-4   AREB6   GATA-6   POU2F1   POU2F1a   Chx10   TGIF   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidMLANA promoter sequence
   Search Chromatin IP Primers for MLANA

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat MLANA


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 9p24.1   Ensembl cytogenetic band:  9p24.1   HGNC cytogenetic band: 9p24.1

MLANA Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
MLANA gene location

GeneLoc information about chromosome 9         GeneLoc Exon Structure

GeneLoc location for GC09P005846:  view genomic region     (about GC identifiers)

Start:
5,890,802 bp from pter      End:
5,910,606 bp from pter
Size:
19,805 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: MAR1_HUMAN, Q16655 (See protein sequence)
Recommended Name: Melanoma antigen recognized by T-cells 1  
Size: 118 amino acids; 13157 Da
Subunit: Interacts with PMEL. Interacts with GPR143
Selected PDB 3D structures from and Proteopedia for MLANA (see all 10):
2GT9 (3D)        2GTW (3D)        2GTZ (3D)        2GUO (3D)        3L6F (3D)        3MRO (3D)    
Secondary accessions: Q6ICU4

Explore the universe of human proteins at neXtProt for MLANA: NX_Q16655

Explore proteomics data for MLANA at MOPED

Post-translational modifications: 

  • Acylated1
  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See MLANA Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_005502.1  
    ENSEMBL proteins: 
     ENSP00000370886   ENSP00000370885   ENSP00000370880  

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    antibodies-online proteins for MLANA (5 products) 

     
    antibodies-online peptides for MLANA

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    antibodies-online antibodies for MLANA (126 products) 

    MLANA Assay Products:

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    Cloud-Clone Corp. CLIAs for MLANA
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    antibodies-online kits for MLANA (12 products) 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    ProtoNet protein and cluster: Q16655


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: MAR1_HUMAN, Q16655
    Function: Involved in melanosome biogenesis by ensuring the stability of GPR143. Plays a vital role in the
    expression, stability, trafficking, and processing of melanocyte protein PMEL, which is critical to the formation
    of stage II melanosomes

         Gene Ontology (GO): 1 molecular function term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding IPI15695812
         
    Find genes that share ontologies with MLANA           About GenesLikeMe


    Phenotypes:
         3 MGI mutant phenotypes (inferred from 2 alleles(MGI details for Mlana):
     integument  no phenotypic analysis  pigmentation 

    Find genes that share phenotypes with MLANA           About GenesLikeMe

    Animal Models:
         MGI mouse knock-out Mlanatm1.2Bee for MLANA

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for MLANA
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for MLANA

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       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for MLANA

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    Selected qRT-PCR Assays for microRNAs that regulate MLANA (see all 12):
    hsa-miR-21* hsa-miR-203 hsa-miR-1206 hsa-miR-548p hsa-miR-595 hsa-miR-1266 hsa-miR-3616-5p hsa-miR-3647-5p
    SwitchGear 3'UTR luciferase reporter plasmidMLANA 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat MLANA

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    eBioscience FlowRNA Probe Sets ( VA6-11568) for MLANA 


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    MAR1_HUMAN, Q16655: Endoplasmic reticulum membrane; Single-pass type III membrane protein. Golgi apparatus.
    Golgi apparatus, trans-Golgi network membrane. Melanosome. Note=Also found in small vesicles and tubules
    dispersed over the entire cytoplasm. A small fraction of the protein is inserted into the membrane in an inverted
    orientation. Inversion of membrane topology results in the relocalization of the protein from a predominant
    Golgi/post-Golgi area to the endoplasmic reticulum. Melanoma cells expressing the protein with an inverted
    membrane topology are more effectively recognized by specific cytolytic T-lymphocytes than those expressing the
    protein in its native membrane orientation
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    endoplasmic reticulum5
    golgi apparatus5
    plasma membrane4
    cytoskeleton3
    cytosol2
    nucleus2
    extracellular1
    mitochondrion1
    peroxisome1

    Gene Ontology (GO): 5 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005789endoplasmic reticulum membrane IDA15695812
    GO:0005794Golgi apparatus IDA12191019
    GO:0005802trans-Golgi network IDA12191019
    GO:0005887integral component of plasma membrane TAS8170938
    GO:0042470melanosome IDA15695812

    Find genes that share ontologies with MLANA           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for MLANA
    Interactions:

        GeneGlobe Interaction Network for MLANA

    STRING Interaction Network Preview (showing 4 interactants - click image to see more details)

    4 Interacting proteins for MLANA (Q166552, 3 ENSP000003708804) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ITCHQ96J022, 3, ENSP000003639984MINT-7889653 I2D: score=2 STRING: ENSP00000363998
    NEDD4P469342, 3, ENSP000003455304MINT-7889653 I2D: score=2 STRING: ENSP00000345530
    GPR143P518103, ENSP000003703164I2D: score=1 STRING: ENSP00000370316
    UBCP0CG483, ENSP000003448184I2D: score=1 STRING: ENSP00000344818
    About this table

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for MLANA (MAR1)

    4 Novoseek inferred chemical compound relationships for MLANA gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    paraffin 37.8 3 16405409 (1), 19667333 (1), 15113392 (1)
    hematoxylin 29.1 2 12960803 (1), 16405409 (1)
    steroid 0 1 9422316 (1)
    lactate 0 1 16179868 (1)



    Find genes that share compounds with MLANA           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for MLANA gene: 
    NM_005511.1  

    Unigene Cluster for MLANA:

    Melan-A
    Hs.154069  [show with all ESTs]
    Unigene Representative Sequence: NM_005511
    5 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000381477(uc003zjo.1) ENST00000381476 ENST00000381471 ENST00000482341
    ENST00000490518
    miRNA
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    Selected qRT-PCR Assays for microRNAs that regulate MLANA (see all 12):
    hsa-miR-21* hsa-miR-203 hsa-miR-1206 hsa-miR-548p hsa-miR-595 hsa-miR-1266 hsa-miR-3616-5p hsa-miR-3647-5p
    SwitchGear 3'UTR luciferase reporter plasmidMLANA 3' UTR sequence
    Inhib. RNA
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    Additional mRNA sequence: 

    AK312149.1 BC014423.1 CR450299.1 U06452.1 U06654.1 

    8 DOTS entries:

    DT.114514  DT.441148  DT.92431925  DT.95259238  DT.95159375  DT.100685191  DT.91993863  DT.95159374 

    Selected AceView cDNA sequences (see all 142):

    CR623651 BQ678597 N24796 BU155807 BC014423 N26562 CR613373 BU165857 
    BU726393 BF725502 U06452 BQ677646 BM705061 BE891265 AA233891 BU195377 
    NM_005511 AI274604 BX444322 BQ677630 BX423914 BM548958 CR450299 BM663875 

    GeneLoc Exon Structure

    5 Alternative Splicing Database (ASD) splice patterns (SP) for MLANA    About this scheme

    ExUns: 1a · 1b ^ 2a · 2b ^ 3a · 3b ^ 4 ^ 5a · 5b ^ 6a · 6b · 6c
    SP1:              -     -                             -                     
    SP2:                                                  -                     
    SP3:                    -                             -                     
    SP4:                                      -           -                     
    SP5:                                                                        


    ECgene alternative splicing isoforms for MLANA

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    MLANA expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TGAGGAAATG
    MLANA Expression
    About this image


    MLANA expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 6) fully expand
     
     Eye (Sensory Organs)    fully expand to see all 3 entries
             Mature Retinal Pigmented Epithelium Cells Retinal Pigmented Epithelium
     
     Melanocytes (Integumentary System)    fully expand to see all 4 entries
             Human EpiDermal Melanocytes-medium (HEM-m)   
     
     Epithelial Cells
             Mature Retinal Pigmented Epithelium Cells Retinal Pigmented Epithelium
     
     Epidermis (Integumentary System)    fully expand to see all 3 entries
             Human EpiDermal Melanocytes-medium (HEM-m)   
     
     NULL (Integumentary System)
             skin 1 ; melanocytes   
    MLANA Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    MLANA Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.154069

    UniProtKB/Swiss-Prot: MAR1_HUMAN, Q16655
    Tissue specificity: Expression is restricted to melanoma and melanocyte cell lines and retina

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    In Situ
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MLANA

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for MLANA gene from Selected species (see all 8)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Mlana1 , 5 melan-A1, 5 77.58(n)1
    71.68(a)1
      19 (24.28 cM)5
    778361  NM_029993.11  NP_084269.11 
     296979415 
    chicken
    (Gallus gallus)
    Aves MLANA1 melan-A 60.71(n)
    51.79(a)
      769648  XM_001232042.3  XP_001232043.1 
    lizard
    (Anolis carolinensis)
    Reptilia MLANA6
    melan-A
    46(a)
    1 ↔ 1
    2(52507620-52516853)


    ENSEMBL Gene Tree for MLANA (if available)
    TreeFam Gene Tree for MLANA (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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      --

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for MLANA (see all 437)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 9 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs733953571,2
    C,F--5888971(+) AGTGGC/TTGGTC 1 -- us2k15Minor allele frequency- T:0.20WA NA 244
    rs1155968121,2
    C,F--5889015(+) AACTTG/CCACCG 1 -- us2k11Minor allele frequency- C:0.08WA 118
    rs1927477341,2
    --5889068(+) ATCCAC/TTACAT 1 -- us2k10--------
    rs64770181,2
    C,F,A--5889099(+) ccattA/Gtatct 1 -- us2k17Minor allele frequency- G:0.13NA WA EA 366
    rs1844911271,2
    --5889137(+) TTGCAC/TCGAAT 1 -- us2k10--------
    rs751859131,2
    C,F--5889205(+) CACCTA/GACCAC 1 -- us2k12Minor allele frequency- G:0.03WA 120
    rs1170135801,2
    F--5889210(+) AACCAC/AATGTC 1 -- us2k11Minor allele frequency- A:0.02EA 120
    rs1467621101,2
    --5889405(+) TGAAGC/TATGAA 1 -- us2k10--------
    rs586416351,2
    C--5889561(+) GCAGGC/TGGATC 1 -- us2k11Minor allele frequency- T:0.50WA 2
    rs1878133751,2
    --5889590(+) GACCAC/TCCTGG 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for MLANA (5890802 - 5910606 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 3 variations for MLANA:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv6464CNV Insertion18451855
    nsv892156CNV Gain21882294
    nsv892155CNV Gain21882294

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing MLANA
    DNA2.0 Custom Variant and Variant Library Synthesis for MLANA

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 605513    OMIM disorders: --

    6 diseases for MLANA:    
    About MalaCards
    halo nevi    juvenile xanthogranuloma    lentigo maligna melanoma    retroperitoneal sarcoma
    melanoma of soft parts    posterior uveal melanoma

    9 diseases from the University of Copenhagen DISEASES database for MLANA:
    Melanoma     Perivascular epithelioid cell tumor     Angiomyolipoma     Microphthalmia
    Lymphangioleiomyomatosis     Sarcoma     Leiomyosarcoma     Vitiligo
    Skin cancer

    Find genes that share disorders with MLANA           About GenesLikeMe

    Selected Novoseek inferred disease relationships for MLANA gene (see all 26)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    melanoma 86.5 199 12735792 (5), 12472287 (4), 11169510 (4), 10360670 (3) (see all 99)
    metastatic melanoma 84.5 10 17414440 (1), 10803712 (1), 12843797 (1), 11511319 (1) (see all 9)
    microphthalmia 71.5 14 11145253 (5), 12472287 (1), 11803278 (1), 15731577 (1) (see all 9)
    stage iii melanoma 70.9 1 12829676 (1)
    nevi melanocytic 70.6 6 10871066 (3), 10688724 (2), 9706977 (1)
    nevi 68.1 9 20142539 (2), 9706977 (2), 15141316 (1), 11493377 (1) (see all 6)
    vitiligo 64.1 9 11979069 (3), 16778827 (1), 16260696 (1), 9672845 (1) (see all 6)
    tumors 57.5 54 12649671 (3), 11145253 (2), 10688724 (2), 12472287 (1) (see all 43)
    angiomyolipoma 57.1 11 11145253 (4), 10389626 (2), 11914628 (2), 17227112 (1)
    granular cell tumor 52.4 1 17284958 (1)

    Genetic Association Database (GAD): MLANA
    Human Genome Epidemiology (HuGE) Navigator: MLANA (1 document)

    Export disorders for MLANA gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for MLANA gene, integrated from 10 sources (see all 257):
    (articles sorted by number of sources associating them with MLANA)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Cloning of the gene coding for a shared human melanoma antigen recognized by autologous T cells infiltrating into tumor. (PubMed id 8170938)1, 2, 9 Kawakami Y.... Rosenberg S.A. (Proc. Natl. Acad. Sci. U.S.A. 1994)
    2. Genome-wide meta-analysis identifies novel multiple sclerosis susceptibility loci. (PubMed id 22190364)1, 4 Patsopoulos N.A....de Bakker P.I. (Ann. Neurol. 2011)
    3. Structural basis for the presentation of tumor-associated MHC class II-restricted phosphopeptides to CD4+ T cells. (PubMed id 20417641)1, 2 Li Y.... Mariuzza R.A. (J. Mol. Biol. 2010)
    4. The ocular albinism type 1 (OA1) G-protein-coupled receptor functions with MART-1 at early stages of melanogenesis to control melanosome identity and composition. (PubMed id 19717472)1, 2 Giordano F.... Raposo G. (Hum. Mol. Genet. 2009)
    5. Pigmentation-related genes and their implication in malignant melanoma susceptibility. (PubMed id 19320733)1, 4 Fernandez L.P....Ribas G. (Exp. Dermatol. 2009)
    6. MART-1 is required for the function of the melanosomal matrix protein PMEL17/GP100 and the maturation of melanosomes. (PubMed id 15695812)1, 2 Hoashi T....Hearing V.J. (J. Biol. Chem. 2005)
    7. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    8. The melanocytic protein Melan-A/MART-1 has a subcellular localization distinct from typical melanosomal proteins. (PubMed id 12191019)1, 2 De Maziere A.M.... Rimoldi D. (Traffic 2002)
    9. A new gene coding for a differentiation antigen recognized by autologous cytolytic T lymphocytes on HLA-A2 melanomas. (PubMed id 8006593)1, 2 Coulie P.G.... Boon T. (J. Exp. Med. 1994)
    10. Differential expression of melanocytic markers in myoid, lipomatous, and vascular components of renal angiomyolipomas. (PubMed id 17227112)1, 9 Roma A.A....Zhou M. (amp 2007)

    (in PubMed, OMIM, and NCBI Bookshelf)
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    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
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      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 2315 HGNC: 7124 AceView: MLANA Ensembl:ENSG00000120215 euGenes: HUgn2315
    ECgene: MLANA H-InvDB: MLANA

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for MLANA Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for MLANA Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for MLANA gene:
    Search GeneIP for patents involving MLANA

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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