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Aliases for MKX Gene

Aliases for MKX Gene

  • Mohawk Homeobox 2 3 5
  • Iroquois Homeobox Protein-Like 1 2 3
  • C10orf48 3 4
  • IRXL1 3 4
  • Iroquois Family Related Homeodomain Protein 3
  • Chromosome 10 Open Reading Frame 48 2
  • IFRX 3

External Ids for MKX Gene

Previous HGNC Symbols for MKX Gene

  • C10orf48
  • IRXL1

Previous GeneCards Identifiers for MKX Gene

  • GC10M028003
  • GC10M027961

Summaries for MKX Gene

Entrez Gene Summary for MKX Gene

  • The protein encoded by this gene is an IRX family-related homeobox protein that may play a role in cell adhesion. Studies in mice suggest that this protein may be a regulator of tendon development. Two transcript variants encoding the same protein have been found for this gene.[provided by RefSeq, Jun 2011]

GeneCards Summary for MKX Gene

MKX (Mohawk Homeobox) is a Protein Coding gene. Diseases associated with MKX include Smallpox. GO annotations related to this gene include sequence-specific DNA binding and transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding. An important paralog of this gene is IRX2.

UniProtKB/Swiss-Prot for MKX Gene

  • May act as a morphogenetic regulator of cell adhesion.

Gene Wiki entry for MKX Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MKX Gene

Genomics for MKX Gene

Regulatory Elements for MKX Gene

Enhancers for MKX Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around MKX on UCSC Golden Path with GeneCards custom track

Genomic Location for MKX Gene

27,672,874 bp from pter
27,746,060 bp from pter
73,187 bases
Minus strand

Genomic View for MKX Gene

Genes around MKX on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MKX Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MKX Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MKX Gene

Proteins for MKX Gene

  • Protein details for MKX Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Homeobox protein Mohawk
    Protein Accession:
    Secondary Accessions:
    • B3KWM5

    Protein attributes for MKX Gene

    352 amino acids
    Molecular mass:
    39331 Da
    Quaternary structure:
    No Data Available

neXtProt entry for MKX Gene

Proteomics data for MKX Gene at MOPED

Post-translational modifications for MKX Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for MKX Gene

No data available for DME Specific Peptides for MKX Gene

Domains & Families for MKX Gene

Gene Families for MKX Gene

Protein Domains for MKX Gene

Suggested Antigen Peptide Sequences for MKX Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Contains 1 homeobox DNA-binding domain.
  • Belongs to the TALE/IRO homeobox family.
  • Contains 1 homeobox DNA-binding domain.
  • Belongs to the TALE/IRO homeobox family.
genes like me logo Genes that share domains with MKX: view

Function for MKX Gene

Molecular function for MKX Gene

UniProtKB/Swiss-Prot Function:
May act as a morphogenetic regulator of cell adhesion.
genes like me logo Genes that share phenotypes with MKX: view

Animal Models for MKX Gene

MGI Knock Outs for MKX:

Animal Model Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for MKX Gene

Localization for MKX Gene

Subcellular locations from UniProtKB/Swiss-Prot for MKX Gene


Subcellular locations from

Jensen Localization Image for MKX Gene COMPARTMENTS Subcellular localization image for MKX gene
Compartment Confidence
nucleus 5
extracellular 1

No data available for Gene Ontology (GO) - Cellular Components for MKX Gene

Pathways & Interactions for MKX Gene

SuperPathways for MKX Gene

No Data Available

Gene Ontology (GO) - Biological Process for MKX Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007517 muscle organ development ISS 16408284
genes like me logo Genes that share ontologies with MKX: view

No data available for Pathways by source and SIGNOR curated interactions for MKX Gene

Drugs & Compounds for MKX Gene

No Compound Related Data Available

Transcripts for MKX Gene

Unigene Clusters for MKX Gene

Mohawk homeobox:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for MKX Gene

ExUns: 1a · 1b ^ 2a · 2b ^ 3 ^ 4 ^ 5 ^ 6 ^ 7
SP1: -
SP2: -

Relevant External Links for MKX Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for MKX Gene

mRNA expression in normal human tissues for MKX Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for MKX Gene

This gene is overexpressed in Prostate (x4.5).

Protein differential expression in normal tissues from HIPED for MKX Gene

This gene is overexpressed in Tlymphocyte (37.7) and Heart (26.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for MKX Gene

SOURCE GeneReport for Unigene cluster for MKX Gene Hs.128193

genes like me logo Genes that share expression patterns with MKX: view

Protein tissue co-expression partners for MKX Gene

Primer Products

No data available for mRNA Expression by UniProt/SwissProt for MKX Gene

Orthologs for MKX Gene

This gene was present in the common ancestor of animals.

Orthologs for MKX Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia MKX 35
  • 89.68 (n)
  • 95.17 (a)
MKX 36
  • 95 (a)
(Canis familiaris)
Mammalia MKX 35
  • 91.1 (n)
  • 95.45 (a)
-- 36
  • 94 (a)
-- 36
  • 95 (a)
-- 36
  • 81 (a)
(Mus musculus)
Mammalia Mkx 35
  • 85.51 (n)
  • 89.2 (a)
Mkx 16
Mkx 36
  • 88 (a)
(Pan troglodytes)
Mammalia MKX 35
  • 99.43 (n)
  • 99.72 (a)
MKX 36
  • 100 (a)
(Rattus norvegicus)
Mammalia Mkx 35
  • 86.09 (n)
  • 89.93 (a)
(Monodelphis domestica)
Mammalia MKX 36
  • 90 (a)
(Ornithorhynchus anatinus)
Mammalia MKX 36
  • 82 (a)
(Gallus gallus)
Aves MKX 35
  • 84.24 (n)
  • 90.35 (a)
MKX 36
  • 90 (a)
(Anolis carolinensis)
Reptilia MKX 36
  • 87 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia mkx 35
  • 74.88 (n)
  • 81.38 (a)
(Danio rerio)
Actinopterygii mkxa 35
  • 66.96 (n)
  • 72.09 (a)
mkxa 36
  • 70 (a)
mkxb 36
  • 73 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG11617 36
  • 27 (a)
(Caenorhabditis elegans)
Secernentea irx-1 36
  • 15 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 12 (a)
Species with no ortholog for MKX:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for MKX Gene

Gene Tree for MKX (if available)
Gene Tree for MKX (if available)

Paralogs for MKX Gene

Paralogs for MKX Gene

(2) SIMAP similar genes for MKX Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with MKX: view

Variants for MKX Gene

Sequence variations from dbSNP and Humsavar for MKX Gene

SNP ID Clin Chr 10 pos Sequence Context AA Info Type
VAR_033875 -
rs2999980 -- 27,698,250(+) CCAAG(A/G)TAAGG intron-variant
rs1907370 -- 27,679,414(+) GCAGT(C/T)TCTGT intron-variant
rs1907371 -- 27,679,568(+) CAGAA(G/T)AGCCA intron-variant
rs1907372 -- 27,684,697(+) CAGCT(C/T)CATCC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for MKX Gene

Variant ID Type Subtype PubMed ID
esv2734606 CNV Deletion 23290073
esv2734639 CNV Deletion 23290073
esv4953 CNV Deletion 18987735
esv2677848 CNV Deletion 23128226
esv7833 CNV Loss 19470904
esv2734650 CNV Deletion 23290073
esv2734661 CNV Deletion 23290073
nsv831813 CNV Loss 17160897

Variation tolerance for MKX Gene

Residual Variation Intolerance Score: 80.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.66; 56.95% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for MKX Gene

Human Gene Mutation Database (HGMD)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MKX Gene

Disorders for MKX Gene

MalaCards: The human disease database

(1) MalaCards diseases for MKX Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
  • ordinary smallpox
- elite association - COSMIC cancer census association via MalaCards
Search MKX in MalaCards View complete list of genes associated with diseases

Relevant External Links for MKX

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
genes like me logo Genes that share disorders with MKX: view

No data available for UniProtKB/Swiss-Prot and Genatlas for MKX Gene

Publications for MKX Gene

  1. Maternal genes and facial clefts in offspring: a comprehensive search for genetic associations in two population-based cleft studies from Scandinavia. (PMID: 20634891) Jugessur A. … Murray J.C. (PLoS ONE 2010) 3 48 67
  2. Mohawk is a novel homeobox gene expressed in the developing mouse embryo. (PMID: 16408284) Anderson D.M. … Rawls A. (Dev. Dyn. 2006) 2 3
  3. In silico characterization of an Iroquois family-related homeodomain protein. (PMID: 16077953) Weinmann A. … Teufel A. (Int. J. Mol. Med. 2005) 3 23
  4. Transcription factor Mohawk controls tenogenic differentiation of bone marrow mesenchymal stem cells in vitro and in vivo. (PMID: 25312837) Otabe K. … Asahara H. (J. Orthop. Res. 2015) 3
  5. Mohawk promotes the tenogenesis of mesenchymal stem cells through activation of the TGFI^ signaling pathway. (PMID: 25332192) Liu H. … Ouyang H.W. (Stem Cells 2015) 3

Products for MKX Gene

Sources for MKX Gene