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Aliases for MKX Gene

Aliases for MKX Gene

  • Mohawk Homeobox 2 3
  • IRXL1 3 4 6
  • Iroquois Homeobox Protein-Like 1 2 3
  • C10orf48 3 4
  • IFRX 3 6
  • Iroquois Family Related Homeodomain Protein 3
  • Chromosome 10 Open Reading Frame 48 2
  • Homeobox Protein Mohawk 3

External Ids for MKX Gene

Previous HGNC Symbols for MKX Gene

  • C10orf48
  • IRXL1

Previous GeneCards Identifiers for MKX Gene

  • GC10M028003
  • GC10M027961

Summaries for MKX Gene

Entrez Gene Summary for MKX Gene

  • The protein encoded by this gene is an IRX family-related homeobox protein that may play a role in cell adhesion. Studies in mice suggest that this protein may be a regulator of tendon development. Two transcript variants encoding the same protein have been found for this gene.[provided by RefSeq, Jun 2011]

GeneCards Summary for MKX Gene

MKX (Mohawk Homeobox) is a Protein Coding gene. GO annotations related to this gene include sequence-specific DNA binding and RNA polymerase II transcription factor binding. An important paralog of this gene is IRX3.

UniProtKB/Swiss-Prot for MKX Gene

  • May act as a morphogenetic regulator of cell adhesion.

Gene Wiki entry for MKX Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MKX Gene

Genomics for MKX Gene

Regulatory Elements for MKX Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for MKX Gene

Start:
27,672,874 bp from pter
End:
27,746,060 bp from pter
Size:
73,187 bases
Orientation:
Minus strand

Genomic View for MKX Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for MKX Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MKX Gene

Proteins for MKX Gene

  • Protein details for MKX Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8IYA7-MKX_HUMAN
    Recommended name:
    Homeobox protein Mohawk
    Protein Accession:
    Q8IYA7
    Secondary Accessions:
    • B3KWM5

    Protein attributes for MKX Gene

    Size:
    352 amino acids
    Molecular mass:
    39331 Da
    Quaternary structure:
    No Data Available

neXtProt entry for MKX Gene

Proteomics data for MKX Gene at MOPED

Post-translational modifications for MKX Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for MKX Gene

Antibody Products

No data available for DME Specific Peptides for MKX Gene

Domains for MKX Gene

Gene Families for MKX Gene

HGNC:
  • TALE :Homeoboxes / TALE class

Protein Domains for MKX Gene

Suggested Antigen Peptide Sequences for MKX Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q8IYA7

UniProtKB/Swiss-Prot:

MKX_HUMAN :
  • Q8IYA7
Domain:
  • Contains 1 homeobox DNA-binding domain.
Family:
  • Belongs to the TALE/IRO homeobox family.
genes like me logo Genes that share domains with MKX: view

Function for MKX Gene

Molecular function for MKX Gene

UniProtKB/Swiss-Prot Function:
May act as a morphogenetic regulator of cell adhesion.

Gene Ontology (GO) - Molecular Function for MKX Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000978 RNA polymerase II core promoter proximal region sequence-specific DNA binding IEA --
GO:0000981 sequence-specific DNA binding RNA polymerase II transcription factor activity --
GO:0001077 RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription IEA --
GO:0001078 RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription IEA --
GO:0001085 RNA polymerase II transcription factor binding IEA --
genes like me logo Genes that share ontologies with MKX: view
genes like me logo Genes that share phenotypes with MKX: view

Animal Models for MKX Gene

MGI Knock Outs for MKX:

Animal Model Products

miRNA for MKX Gene

miRTarBase miRNAs that target MKX

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for MKX

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targeting and HOMER Transcription for MKX Gene

Localization for MKX Gene

Subcellular locations from UniProtKB/Swiss-Prot for MKX Gene

Nucleus.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for MKX Gene COMPARTMENTS Subcellular localization image for MKX gene
Compartment Confidence
nucleus 4
extracellular 1

Gene Ontology (GO) - Cellular Components for MKX Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
genes like me logo Genes that share ontologies with MKX: view

Pathways for MKX Gene

SuperPathways for MKX Gene

No Data Available

PCR Array Products

  • Pathway & Disease-focused RT² Profiler PCR Arrays

Gene Ontology (GO) - Biological Process for MKX Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000122 negative regulation of transcription from RNA polymerase II promoter IEA --
GO:0002932 tendon sheath development IEA --
GO:0006355 regulation of transcription, DNA-templated --
GO:0006366 transcription from RNA polymerase II promoter IEA --
GO:0007517 muscle organ development ISS 16408284
genes like me logo Genes that share ontologies with MKX: view

No data available for Pathways by source for MKX Gene

Transcripts for MKX Gene

Unigene Clusters for MKX Gene

Mohawk homeobox:
Representative Sequences:

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for MKX

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for MKX Gene

ExUns: 1a · 1b ^ 2a · 2b ^ 3 ^ 4 ^ 5 ^ 6 ^ 7
SP1: -
SP2: -
SP3:

Relevant External Links for MKX Gene

GeneLoc Exon Structure for
MKX
ECgene alternative splicing isoforms for
MKX

Expression for MKX Gene

mRNA expression in normal human tissues for MKX Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for MKX Gene

This gene is overexpressed in Prostate (4.5).

Protein differential expression in normal tissues for MKX Gene

This gene is overexpressed in Tlymphocyte (37.7) and Heart (26.4).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for MKX Gene

SOURCE GeneReport for Unigene cluster for MKX Gene Hs.128193

genes like me logo Genes that share expressions with MKX: view

Expression partners for MKX Gene

In Situ Assay Products

No data available for mRNA Expression by UniProt/SwissProt for MKX Gene

Orthologs for MKX Gene

This gene was present in the common ancestor of animals.

Orthologs for MKX Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia MKX 35
  • 89.68 (n)
  • 95.17 (a)
MKX 36
  • 95 (a)
OneToOne
dog
(Canis familiaris)
Mammalia MKX 35
  • 91.1 (n)
  • 95.45 (a)
-- 36
  • 94 (a)
OneToMany
-- 36
  • 95 (a)
OneToMany
-- 36
  • 81 (a)
OneToMany
mouse
(Mus musculus)
Mammalia Mkx 35
  • 85.51 (n)
  • 89.2 (a)
Mkx 16
Mkx 36
  • 88 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia MKX 35
  • 99.43 (n)
  • 99.72 (a)
MKX 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Mkx 35
  • 86.09 (n)
  • 89.93 (a)
oppossum
(Monodelphis domestica)
Mammalia MKX 36
  • 90 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia MKX 36
  • 82 (a)
OneToOne
chicken
(Gallus gallus)
Aves MKX 35
  • 84.24 (n)
  • 90.35 (a)
MKX 36
  • 90 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia MKX 36
  • 87 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia mkx 35
  • 74.88 (n)
  • 81.38 (a)
zebrafish
(Danio rerio)
Actinopterygii mkxa 35
  • 66.96 (n)
  • 72.09 (a)
mkxa 36
  • 70 (a)
OneToMany
mkxb 36
  • 73 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta CG11617 36
  • 27 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea irx-1 36
  • 15 (a)
OneToOne
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 12 (a)
ManyToMany
Species with no ortholog for MKX:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for MKX Gene

ENSEMBL:
Gene Tree for MKX (if available)
TreeFam:
Gene Tree for MKX (if available)

Paralogs for MKX Gene

Paralogs for MKX Gene

Selected SIMAP similar genes for MKX Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with MKX: view

Variants for MKX Gene

Sequence variations from dbSNP and Humsavar for MKX Gene

SNP ID Clin Chr 10 pos Sequence Context AA Info Type MAF
rs1907370 -- 27,679,414(+) GCAGT(C/T)TCTGT intron-variant
rs1907371 -- 27,679,568(+) CAGAA(G/T)AGCCA intron-variant
rs1907372 -- 27,684,697(+) CAGCT(C/T)CATCC intron-variant
rs1907373 -- 27,684,703(+) CATCC(A/G)ACTTA intron-variant
rs1907374 -- 27,740,496(+) CAACT(G/T)CCCCA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for MKX Gene

Variant ID Type Subtype PubMed ID
esv2734606 CNV Deletion 23290073
esv2734639 CNV Deletion 23290073
esv4953 CNV Deletion 18987735
esv2677848 CNV Deletion 23128226
esv7833 CNV Loss 19470904
esv2734650 CNV Deletion 23290073
esv2734661 CNV Deletion 23290073
nsv831813 CNV Loss 17160897

Relevant External Links for MKX Gene

HapMap Linkage Disequilibrium report
MKX
Human Gene Mutation Database (HGMD)
MKX

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MKX Gene

Disorders for MKX Gene

Relevant External Links for MKX

Genetic Association Database (GAD)
MKX
Human Genome Epidemiology (HuGE) Navigator
MKX

No disorders were found for MKX Gene.

No data available for MalaCards , OMIM , UniProtKB/Swiss-Prot , University of Copenhagen DISEASES , Novoseek inferred disease relationships and Genatlas for MKX Gene

Publications for MKX Gene

  1. In silico characterization of an Iroquois family-related homeodomain protein. (PMID: 16077953) Weinmann A. … Teufel A. (Int. J. Mol. Med. 2005) 3 23
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  3. Mohawk is a novel homeobox gene expressed in the developing mouse embryo. (PMID: 16408284) Anderson D.M. … Rawls A. (Dev. Dyn. 2006) 2 3
  4. Maternal genes and facial clefts in offspring: a comprehensive search for genetic associations in two population-based cleft studies from Scandinavia. (PMID: 20634891) Jugessur A. … Murray J.C. (PLoS ONE 2010) 3 48
  5. The atypical homeodomain transcription factor Mohawk controls tendon morphogenesis. (PMID: 20696843) Liu W. … Jiang R. (Mol. Cell. Biol. 2010) 3

Products for MKX Gene

Sources for MKX Gene

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