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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

MKX Gene

protein-coding   GIFtS: 49
GCID: GC10M028003

mohawk homeobox

(Previous names: chromosome 10 open reading frame 48, iroquois homeobox...)
(Previous symbols: C10orf48, IRXL1)
 Explore 1 disease affiliated with
MKX via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for MKX    

Aliases
for MKX gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
Mohawk Homeobox1 2     MGC396161
IRXL11 2 3 5     Chromosome 10 Open Reading Frame 481
C10orf481 2 3     Homeobox Protein Mohawk2
Iroquois Homeobox Protein-Like 11 2     Iroquois Family Related Homeodomain Protein2
IFRX2 5     

External Ids:    HGNC: 237291   Entrez Gene: 2830782   Ensembl: ENSG000001500517   OMIM: 6013325   UniProtKB: Q8IYA73   

Export aliases for MKX gene to outside databases

Previous GC identifer: GC10M027682


Summaries
for MKX gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for MKX:
The protein encoded by this gene is an IRX family-related homeobox protein that may play a role in cell adhesion.
Studies in mice suggest that this protein may be a regulator of tendon development. Two transcript variants encoding
the same protein have been found for this gene.(provided by RefSeq, Jun 2011)

UniProtKB/Swiss-Prot: MKX_HUMAN, Q8IYA7
Function: May act as a morphogenetic regulator of cell adhesion (By similarity)

Gene Wiki entry for MKX


Genomic Views
for MKX gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000010.10  NC_018921.1  NT_008705.16  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the MKX gene promoter:
         Elk-1   Pax-5   POU3F1   STAT5A   IRF-1   Cdc5   AP-2beta   Cart-1   AP-2alpha   AP-2alphaA   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: MKX promoter sequence
   Search SABiosciences Chromatin IP Primers for MKX

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat MKX


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 10p12.1   Ensembl cytogenetic band:  10p12.1   HGNC cytogenetic band: 10p12.1

MKX Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
MKX gene location

GeneLoc information about chromosome 10         GeneLoc Exon Structure

GeneLoc location for GC10M028003:  view genomic region     (about GC identifiers)

Start:
 27,961,803 bp from pter      End:
 28,034,989 bp from pter
Size:
 73,187 bases      Orientation:
 minus strand

Proteins
for MKX gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: MKX_HUMAN, Q8IYA7 (See protein sequence)
Recommended Name: Homeobox protein Mohawk  
Size: 352 amino acids; 39331 Da
Subcellular location: Nucleus (Probable)
Secondary accessions: B3KWM5

Explore the universe of human proteins at neXtProt for MKX: NX_Q8IYA7

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q8IYA7

    • MKX Protein expression data from MOPED and PaxDb:    About this image 
    MKX Protein Expression
    REFSEQ proteins (2 alternative transcripts): 
    NP_001229631.1  NP_775847.2  

    ENSEMBL proteins: 
     ENSP00000364946   ENSP00000452751   ENSP00000453746   ENSP00000400896  

    Human Recombinant Protein Products for MKX: 
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    OriGene Protein Over-expression Lysate: MKX
    OriGene Custom Protein Services for MKX 
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    Novus Biologicals MKX Proteins
    Novus Biologicals MKX Lysate
    Browse Sino Biological Recombinant Proteins
    Browse ProSpec Recombinant Proteins
    Uscn Proteins for MKX

    Gene Ontology (GO): 1 cellular component term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IEA--

    MKX for ontologies           About GeneDecksing



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    Uscn ELISAs and CLIAs for MKX

    Protein Domains /
    Families
    for MKX gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    MKX for domains           About GeneDecksing

    4 InterPro domains/families:
     IPR008422 Homeobox_KN_domain
     IPR017970 Homeobox_CS
     IPR001356 Homeodomain
     IPR009057 Homeodomain-like

    Graphical View of Domain Structure for InterPro Entry Q8IYA7

    ProtoNet protein and cluster: Q8IYA7

    UniProtKB/Swiss-Prot: MKX_HUMAN, Q8IYA7
    Similarity: Belongs to the TALE/IRO homeobox family
    Similarity: Contains 1 homeobox DNA-binding domain


    Function
    for MKX gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, Sirion Biotech, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, Sirion Biotech, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Molecular Function:

         UniProtKB/Swiss-Prot Summary: MKX_HUMAN, Q8IYA7
    Function: May act as a morphogenetic regulator of cell adhesion (By similarity)

         Gene Ontology (GO): 5 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000981sequence-specific DNA binding RNA polymerase II transcription factor activity IEA--
    GO:0001085RNA polymerase II transcription factor binding IEA--
    GO:0003700sequence-specific DNA binding transcription factor activity ----
    GO:0005515protein binding ----
    GO:0043565sequence-specific DNA binding IEA--
         
    MKX for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for MKX:
     Increased cilium length after  

         4 MGI mutant phenotypes (inferred from 5 alleles) (MGI details for Mkx):
     limbs/digits/tail  muscle  no phenotypic analysis  skeleton 

    MKX for phenotypes           About GeneDecksing

    Animal Models:
         Mouse knock-outs for MKX: Mkxtm1Miu Mkxtm1.2Jian
       inGenious Targeting Laboratory - Customizable classic, inducible, and humanized mouse model solutions for MKX 

    miRNA
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    Browse MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat MKX
    8/29 QIAGEN miScript miRNA Assays for microRNAs that regulate MKX (see all 29):
    hsa-miR-548j hsa-miR-548i hsa-miR-485-3p hsa-miR-374a hsa-miR-570 hsa-miR-1304 hsa-miR-124 hsa-miR-3662
    SwitchGear 3'UTR luciferase reporter plasmid: MKX 3' UTR sequence
    Inhib. RNA
    Products:            		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for MKX (see all 4)
    OriGene shRNA RFP: MKX
    OriGene siRNA: MKX
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat MKX
    Sirion Biotech Custom design and validation of potent shRNA sequences against MKX 

    Gene Editing
    Products:    		DNA2.0 Custom Protein Engineering Service for MKX
    Sirion Biotech Customized adenovirus for overexpression of MKX 
    Sirion Biotech Customized adenovirus for potent knockdown of MKX

    Clone
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    OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for MKX (see all 2)
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MKX 

    Cell Line
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    Search LifeMap BioReagents cell lines for MKX
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    Sirion Biotech Customized inducible overexpressing cell line services for MKX

    In Situ Assay
    Products:       
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MKX


    Pathways & Interactions
    for MKX gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section



    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for MKX

    STRING Interaction Network Preview (showing 5 interactants - click image to see 6)

    5/6 Interacting proteins for MKX (Q8IYA73 ENSP000003649464) via UniProtKB, MINT, STRING, and/or I2D (see all 6)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    GTF2A1P526553, ENSP000002981734I2D: score=1 STRING: ENSP00000298173
    TBPP202263, ENSP000002303544I2D: score=1 STRING: ENSP00000230354
    SIN3AQ96ST33, ENSP000003536224I2D: score=1 STRING: ENSP00000353622
    GTF2BQ004033, ENSP000003595314I2D: score=1 STRING: ENSP00000359531
    HDAC1Q135473, ENSP000003626494I2D: score=1 STRING: ENSP00000362649
    About this table

    Gene Ontology (GO): 5/11 biological process terms (GO ID links to tree view) (see all 11):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000122negative regulation of transcription from RNA polymerase II promoter IEA--
    GO:0002932tendon sheath development IEA--
    GO:0006366transcription from RNA polymerase II promoter ----
    GO:0007517muscle organ development ISS16408284
    GO:0010468regulation of gene expression ----

    MKX for ontologies           About GeneDecksing



    Drugs & Compounds
    for MKX gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for MKX
    Search CenterWatch for drugs/clinical trials and news about MKX 

    Transcripts
    for MKX gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, Sirion Biotech, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for MKX gene (2 alternative transcripts): 
    NM_001242702.1  NM_173576.2  

    Unigene Cluster for MKX:

    Mohawk homeobox
    Hs.128193  [show with all ESTs]
    Unigene Representative Sequence: NM_173576
    4 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000375790(uc001itx.4) ENST00000460919 ENST00000561227 ENST00000419761(uc001ity.4)


    miRNA
    Products:             		 OriGene 3'-UTR Clone: MKX
    Browse OriGene MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat MKX
    8/29 QIAGEN miScript miRNA Assays for microRNAs that regulate MKX (see all 29):
    hsa-miR-548j hsa-miR-548i hsa-miR-485-3p hsa-miR-374a hsa-miR-570 hsa-miR-1304 hsa-miR-124 hsa-miR-3662
    SwitchGear 3'UTR luciferase reporter plasmid: MKX 3' UTR sequence
    Inhib. RNA
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    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for MKX (see all 4)
    OriGene shRNA RFP: MKX
    OriGene siRNA: MKX
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat MKX
    Sirion Biotech Custom design and validation of potent shRNA sequences against MKX 
    Clone
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    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for MKX
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector: MKX (NM_173576)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for MKX
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MKX 
    Primer
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    Browse OriGene validated miRNA SYBR primer pairs
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      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat MKX
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat MKX

    Additional cDNA sequence: 

    AK125339.1 BC036207.1 

    2 DOTS entries:

    DT.97774780  DT.40127308 

    24/39 AceView cDNA sequences (see all 39):

    F01353 Z41276 BF108805 AK125339 AI075375 AI910541 BQ937643 BI547447 
    AW298102 AI339844 NM_173576 BQ961518 BC036207 AI805198 BM542857 BF940586 
    CB121713 BM474155 AI910533 BI491189 BI769578 BF058244 Z41858 BU676453 

    GeneLoc Exon Structure

    3 Alternative Splicing Database (ASD) splice patterns (SP) for MKX    About this scheme

    ExUns: 1a · 1b ^ 2a · 2b ^ 3 ^ 4 ^ 5 ^ 6 ^ 7
    SP1:                                            -         
    SP2:                                            -         
    SP3:                                                      


    ECgene alternative splicing isoforms for MKX

    Expression
    for MKX gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    MKX expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: --
    MKX Expression
    About this image

    MKX expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table

    5 LifeMap In Vivo Development Anatomical Compartments/Cells 
    Tissue Anatomical Compartment CellCategory (developmental path)
    Tendons & LigamentsAxial Tendon PrimordiaEarly Tenocyte CellsTendons & Ligaments
    Tendons & LigamentsAxial Tendons and LigamnetsTenocytesTendons & Ligaments
    Tendons & LigamentsLimb Tendon PrimordiaEarly Tenocyte CellsTendons & Ligaments
    Tendons & LigamentsLimb Tendons and LigamnetsTenocytesTendons & Ligaments
    TestisSeminiferous TubulesSertoli cellsTestis
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization
    Stem Cell Differentiation: 7 LifeMap Cells 
    NameCategory
    PureStem™ progenitor E68 (Embryonic Progenitor Cell)
    PureStem™ epithelial progenitor E164 (Embryonic Progenitor Cell)Intermediate Mesoderm, Kidney
    PureStem™ progenitor T42 (Embryonic Progenitor Cell)
    PureStem™ mesenchymal progenitor MEL2 (Embryonic Progenitor Cell)Adipose, Bone, Cartilage
    PureStem™ mesenchymal progenitor E15 (Embryonic Progenitor Cell)Adipose, Bone, Cartilage
    PureStem™ progenitor E69 (Embryonic Progenitor Cell)
    Intervertebral disc (IVD) annulus fibrosus (AF) cells (Differentiation of s...)Cartilage

    See MKX Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for MKX

    SOURCE GeneReport for Unigene cluster: Hs.128193
        SABiosciences Expression via Pathway-Focused PCR Array including MKX: 
              Homeobox (HOX) Genes in human mouse rat

    Primer
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    In Situ
    Assay Products:     
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MKX

    Orthologs
    for MKX gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of animals.

    Orthologs for MKX gene from 5/18 species (see all 18)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    chicken
    (Gallus gallus)    		 Aves MKX1 mohawk homeobox 81.09(n)
    85.97(a)    		   771284  XM_001233725.2  XP_001233726.2 
    lizard
    (Anolis carolinensis)    		 Reptilia MKX6
    		 --
    		 87(a)
    		 1 ↔ 1
    		 6(14173165-14234526)
    zebrafish
    (Danio rerio)    		 Actinopterygii mkxa1 mohawk homeobox a 66.67(n)
    72.09(a)    		   799136  NM_001098733.2  NP_001092203.2 
    fruit fly
    (Drosophila melanogaster)    		 Insecta CG116176
    		 --
    		 19(a)
    		 1 ↔ 1
    		 2L(204743-207297)
    worm
    (Caenorhabditis elegans)    		 Secernentea irx-16
    		 Putative iroquois-class homeodomain protein irx-1
    		 14(a)
    		 1 ↔ 1
    		 I(9536480-9540960)


    ENSEMBL Gene Tree for MKX (if available)
    TreeFam Gene Tree for MKX (if available) 

    Paralogs
    for MKX gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for MKX gene
    IRX12  IRX32  IRX52  IRX22  IRX62  IRX42  
    2 SIMAP similar genes for MKX using alignment to 3 protein entries:     MKX_HUMAN (see all proteins):
    TGIF1    PKNOX1

    MKX for paralogs           About GeneDecksing



    Genomic Variants
    for MKX gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/1331 NCBI SNPs in MKX are shown (see all 1331)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 10 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs796776261,2
    		--27677710(+) AATGAC/TTAAGT 2 -- ds50012Minor allele frequency- T:0.04CSA WA 120
    rs169281401,2
    		C,F,H--27678301(+) CAGCAA/CAAGAA 2 -- ut31 trp313Minor allele frequency- C:0.03NA NS EA WA 1350
    rs412828501,2
    		F--27678855(+) TATATA/GTATAC 2 -- ut311Minor allele frequency- G:0.03NA 120
    rs1166912951,2
    		C,F--27679027(+) NNNNTC/TACCAC 2 -- ut311Minor allele frequency- T:0.02WA 118
    rs783704931,2
    		C,F--27679326(+) TTCAAT/CGCATG 2 -- ut311Minor allele frequency- C:0.02EA 120
    rs122696901,2
    		H--27679606(+) AGGATT/CATGTT 2 -- ut31 ese34Minor allele frequency- C:0.00NS EA 420
    rs741293331,2
    		C--27679822(+) TTAAAT/CGTACA 2 -- ut312Minor allele frequency- C:0.15WA 120
    rs741293341,2
    		C--27680170(+) TTGTCG/AGGAAG 2 -- ut312Minor allele frequency- A:0.03WA 120
    rs21308101,2
    		H--27680203(+) ATGCAG/AATGTT 2 -- ut31 ese34Minor allele frequency- A:0.00NS EA 420
    rs1154751541,2
    		C,F--27680216(+) ATGCAT/CAGTTT 2 -- ut311Minor allele frequency- C:0.03WA 118

    HapMap Linkage Disequilibrium report for MKX (27961803 - 28034989 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 2 variations for MKX
         2 Indels: 41704 60997

    SABiosciences Cancer Mutation PCR Assays
    QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing MKX
    DNA2.0 Custom Variant and Variant Library Synthesis for MKX

    Disorders / Diseases
    for MKX gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    MKX for disorders           About GeneDecksing

    OMIM gene information: 601332    OMIM disorders: --

    1 disease for MKX:    About MalaCards
    smallpox

    Human Genome Epidemiology (HuGE) Navigator: MKX (1 document)

    Export disorders for MKX gene to outside databases

    Publications
    for MKX gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for MKX gene, integrated from 9 sources (see all 16):
    (articles sorted by number of sources associating them with MKX)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. Mohawk is a novel homeobox gene expressed in the developing mouse embryo. (PubMed id 16408284)1, 3 Anderson D.M....Rawls A. (2006)
    2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    3. In silico characterization of an Iroquois family-related homeodomain protein. (PubMed id 16077953)1, 9 Weinmann A....Teufel A. (2005)
    4. Genome-wide association study of antibody response to smallpox vaccine. (PubMed id 22542470)1 Ovsyannikova I.G....Poland G.A. (2012)
    5. The atypical homeodomain transcription factor Mohawk controls tendon morphogenesis. (PubMed id 20696843)1 Liu W....Jiang R. (2010)
    6. Maternal genes and facial clefts in offspring: a comp rehensive search for genetic associations in two population-based cleft studies from Scandinavia. (PubMed id 20634891)1 Jugessur A....Murray J.C. (2010)
    7. The Mohawk homeobox gene is a critical regulator of t endon differentiation. (PubMed id 20498044)1 Ito Y....Asahara H. (2010)
    8. Ubiquitin-mediated proteolysis of HuR by heat shock. (PubMed id 19322201)1 Abdelmohsen K....Gorospe M. (2009)
    9. The homeobox gene Mohawk represses transcription by recruiting the sin3A/HDAC co-repressor complex. (PubMed id 19235719)1 Anderson D.M....Rawls A. (2009)
    10. Toward a confocal subcellular atlas of the human proteome. (PubMed id 18029348)1 Barbe L....Andersson-Svahn H. (2008)

    External Searches for MKX gene

    (in PubMed, OMIM, and NCBI Bookshelf)
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    Genome Databases showing MKX gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 283078 HGNC: 23729 AceView: C10orf48 Ensembl:ENSG00000150051 euGenes: HUgn283078
    ECgene: MKX H-InvDB: MKX

    Other Databases showing MKX gene

    (According to HUGE)
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    Specialized Databases showing MKX gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for MKX Pharmacogenomics, SNPs, Pathways

    Intellectual Property
    for MKX gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for MKX gene:
    Search GeneIP for patents involving MKX

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