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MKX Gene

protein-coding   GIFtS: 51
GCID: GC10M027961

Mohawk Homeobox

(Previous names: chromosome 10 open reading frame 48, iroquois homeobox protein-like...)
(Previous symbols: C10orf48, IRXL1)
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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Mohawk Homeobox1 2     IFRX2 5
IRXL11 2 3 5     Chromosome 10 Open Reading Frame 481
C10orf481 2 3     Homeobox Protein Mohawk2
Iroquois Homeobox Protein-Like 11 2     Iroquois Family Related Homeodomain Protein2

External Ids:    HGNC: 237291   Entrez Gene: 2830782   Ensembl: ENSG000001500517   OMIM: 6013325   UniProtKB: Q8IYA73   

Export aliases for MKX gene to outside databases

Previous GC identifers: GC10M028003 GC10M027682


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for MKX Gene:
The protein encoded by this gene is an IRX family-related homeobox protein that may play a role in cell adhesion.
Studies in mice suggest that this protein may be a regulator of tendon development. Two transcript variants
encoding the same protein have been found for this gene.(provided by RefSeq, Jun 2011)

GeneCards Summary for MKX Gene:
MKX (mohawk homeobox) is a protein-coding gene. GO annotations related to this gene include RNA polymerase II transcription factor binding and sequence-specific DNA binding. An important paralog of this gene is IRX1.

UniProtKB/Swiss-Prot: MKX_HUMAN, Q8IYA7
Function: May act as a morphogenetic regulator of cell adhesion (By similarity)

Gene Wiki entry for MKX Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000010.10  NT_008705.17  NC_018921.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the MKX gene promoter:
         Elk-1   Pax-5   POU3F1   STAT5A   IRF-1   Cdc5   AP-2beta   Cart-1   AP-2alpha   AP-2alphaA   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidMKX promoter sequence
   Search Chromatin IP Primers for MKX

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat MKX


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 10p12.1   Ensembl cytogenetic band:  10p12.1   HGNC cytogenetic band: 10p12.1

MKX Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
MKX gene location

GeneLoc information about chromosome 10         GeneLoc Exon Structure

GeneLoc location for GC10M027961:  view genomic region     (about GC identifiers)

Start:
27,961,803 bp from pter      End:
28,034,989 bp from pter
Size:
73,187 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: MKX_HUMAN, Q8IYA7 (See protein sequence)
Recommended Name: Homeobox protein Mohawk  
Size: 352 amino acids; 39331 Da
Secondary accessions: B3KWM5

Explore the universe of human proteins at neXtProt for MKX: NX_Q8IYA7

Explore proteomics data for MKX at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See MKX Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_001229631.1  NP_775847.2  

    ENSEMBL proteins: 
     ENSP00000364946   ENSP00000452751   ENSP00000453746   ENSP00000400896  

    MKX Human Recombinant Protein Products:

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    Novus Biologicals MKX Proteins
    Novus Biologicals MKX Lysate
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for MKX

     
    Search eBioscience for Proteins for MKX 

     
    antibodies-online proteins for MKX (6 products) 

     
    antibodies-online peptides for MKX

    MKX Antibody Products:

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    antibodies-online antibodies for MKX (23 products) 

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    Cloud-Clone Corp. ELISAs for MKX
    Cloud-Clone Corp. CLIAs for MKX
    Search eBioscience for ELISAs for MKX 
    antibodies-online kits for MKX (4 products) 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    TALE: Homeoboxes / TALE class

    4 InterPro protein domains:
     IPR008422 Homeobox_KN_domain
     IPR017970 Homeobox_CS
     IPR001356 Homeobox_dom
     IPR009057 Homeodomain-like

    Graphical View of Domain Structure for InterPro Entry Q8IYA7

    ProtoNet protein and cluster: Q8IYA7

    UniProtKB/Swiss-Prot: MKX_HUMAN, Q8IYA7
    Similarity: Belongs to the TALE/IRO homeobox family
    Similarity: Contains 1 homeobox DNA-binding domain


    Find genes that share domains with MKX           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: MKX_HUMAN, Q8IYA7
    Function: May act as a morphogenetic regulator of cell adhesion (By similarity)

         Gene Ontology (GO): Selected molecular function terms (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000981sequence-specific DNA binding RNA polymerase II transcription factor activity IEA--
    GO:0001085RNA polymerase II transcription factor binding IEA--
    GO:0003677DNA binding ----
    GO:0003700sequence-specific DNA binding transcription factor activity ----
    GO:0005515protein binding ----
         
    Find genes that share ontologies with MKX           About GenesLikeMe


    Phenotypes:
         1 GenomeRNAi human phenotype for MKX:
     Increased cilium length after  

         4 MGI mutant phenotypes (inferred from 5 alleles(MGI details for Mkx):
     limbs/digits/tail  muscle  no phenotypic analysis  skeleton 

    Find genes that share phenotypes with MKX           About GenesLikeMe

    Animal Models:
         MGI mouse knock-outs for MKX: Mkxtm1Miu Mkxtm1.2Jian

       genOway: Develop your customized and physiologically relevant rodent model for MKX

    miRNA
    Products:
        
    miRTarBase miRNAs that target MKX:
    hsa-mir-148b-3p (MIRT019321), hsa-mir-124-3p (MIRT022766)

    Block miRNA regulation of human, mouse, rat MKX using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate MKX (see all 29):
    hsa-miR-548j hsa-miR-548i hsa-miR-485-3p hsa-miR-374a hsa-miR-570 hsa-miR-1304 hsa-miR-124 hsa-miR-3662
    SwitchGear 3'UTR luciferase reporter plasmidMKX 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat MKX

    Gene Editing
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    DNA2.0 Custom Protein Engineering Service for MKX

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    OriGene ORF clones in mouse, rat for MKX
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    GenScript: all cDNA clones in your preferred vector: MKX (NM_173576)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for MKX
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MKX

    Cell Line
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    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MKX


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    MKX_HUMAN, Q8IYA7: Nucleus (Probable)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus4
    extracellular1

    Gene Ontology (GO): 1 cellular component term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IEA--

    Find genes that share ontologies with MKX           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Pathway & Disease-focused RT2 Profiler PCR Array including MKX: 
              Homeobox (HOX) Genes in human mouse rat

    Interactions:

        Search GeneGlobe Interaction Network for MKX

    STRING Interaction Network Preview (showing 5 interactants - click image to see 10)

    Selected Interacting proteins for MKX (Q8IYA73 ENSP000003649464) via UniProtKB, MINT, STRING, and/or I2D (see all 10)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    GTF2A1P526553, ENSP000002981734I2D: score=1 STRING: ENSP00000298173
    TBPP202263, ENSP000002303544I2D: score=1 STRING: ENSP00000230354
    SIN3AQ96ST33, ENSP000003536224I2D: score=1 STRING: ENSP00000353622
    GTF2BQ004033, ENSP000003595314I2D: score=1 STRING: ENSP00000359531
    HDAC1Q135473, ENSP000003626494I2D: score=1 STRING: ENSP00000362649
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 12):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000122negative regulation of transcription from RNA polymerase II promoter IEA--
    GO:0002932tendon sheath development IEA--
    GO:0006355regulation of transcription, DNA-templated ----
    GO:0006366transcription from RNA polymerase II promoter ----
    GO:0007517muscle organ development ISS16408284

    Find genes that share ontologies with MKX           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for MKX



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for MKX gene (2 alternative transcripts): 
    NM_001242702.1  NM_173576.2  

    Unigene Cluster for MKX:

    Mohawk homeobox
    Hs.128193  [show with all ESTs]
    Unigene Representative Sequence: NM_173576
    4 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000375790(uc001itx.4) ENST00000460919 ENST00000561227 ENST00000419761(uc001ity.4)

    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat MKX using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate MKX (see all 29):
    hsa-miR-548j hsa-miR-548i hsa-miR-485-3p hsa-miR-374a hsa-miR-570 hsa-miR-1304 hsa-miR-124 hsa-miR-3662
    SwitchGear 3'UTR luciferase reporter plasmidMKX 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for MKX
    Predesigned siRNA for gene silencing in human, mouse, rat MKX
    Clone
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    OriGene ORF clones in mouse, rat for MKX
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: MKX (NM_173576)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for MKX
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MKX
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for MKX
    OriGene qSTAR qPCR primer pairs in human, mouse for MKX
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat MKX
      QuantiTect SYBR Green Assays in human, mouse, rat MKX
      QuantiFast Probe-based Assays in human, mouse, rat MKX

    Additional mRNA sequence: 

    AK125339.1 BC036207.1 

    2 DOTS entries:

    DT.97774780  DT.40127308 

    Selected AceView cDNA sequences (see all 39):

    AK125339 Z41276 F01353 AI075375 BF108805 AI910541 BC036207 BQ961518 
    CB121713 BI547447 BF940586 AI805198 BF058244 BM474155 NM_173576 BQ937643 
    BI491189 AI910533 BI769578 Z41858 BM542857 AW298102 AI339844 AA972205 

    GeneLoc Exon Structure

    3 Alternative Splicing Database (ASD) splice patterns (SP) for MKX    About this scheme

    ExUns: 1a · 1b ^ 2a · 2b ^ 3 ^ 4 ^ 5 ^ 6 ^ 7
    SP1:                                            -         
    SP2:                                            -         
    SP3:                                                      


    ECgene alternative splicing isoforms for MKX

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    MKX expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    MKX Expression
    About this image


    MKX expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 6) fully expand
     
     Tendon & Ligament (Muscoskeletal System)    fully expand to see all 4 entries
             Early Tenocyte Cells Limb Tendon Primordia
     
     Cartilage (Muscoskeletal System)
             Intervertebral disc (IVD) annulus fibrosus (AF) cells
     
     Gut Tube (Gastrointestinal Tract)
             Foregut
     
     Testis (Reproductive System)
             Sertoli cells Seminiferous Tubules
     
     Bone (Muscoskeletal System)
             Mandibular Process
    MKX Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    MKX Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.128193
        Pathway & Disease-focused RT2 Profiler PCR Array including MKX: 
              Homeobox (HOX) Genes in human mouse rat

    Primer
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MKX

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for MKX gene from Selected species (see all 15)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Mkx1 , 5 mohawk homeobox1, 5 85.51(n)1
    89.2(a)1
      18 (4.53 cM)5
    2107191  NM_177595.41  NP_808263.21 
     69104595 
    chicken
    (Gallus gallus)
    Aves MKX1 mohawk homeobox 84.24(n)
    90.35(a)
      771284  XM_001233725.3  XP_001233726.3 
    lizard
    (Anolis carolinensis)
    Reptilia MKX6
    mohawk homeobox
    87(a)
    1 ↔ 1
    6(14173003-14238954)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia mkx1 mohawk homeobox 74.88(n)
    81.38(a)
      100493638  XM_004915450.1  XP_004915507.1 
    zebrafish
    (Danio rerio)
    Actinopterygii mkxa1 mohawk homeobox a 66.96(n)
    72.09(a)
      799136  NM_001098733.2  NP_001092203.2 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG116176
    --
    27(a)
    1 ↔ 1
    2L(204743-207297)
    worm
    (Caenorhabditis elegans)
    Secernentea irx-16
    Protein IRX-1 (irx-1) mRNA, complete cds
    15(a)
    1 ↔ 1
    I(9536488-9540968) WBGene00007984


    ENSEMBL Gene Tree for MKX (if available)
    TreeFam Gene Tree for MKX (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for MKX gene
    IRX12  IRX32  IRX52  IRX22  IRX62  IRX42  
    2 SIMAP similar genes for MKX using alignment to 3 protein entries:     MKX_HUMAN (see all proteins):
    TGIF2    TGIF1

    Find genes that share paralogs with MKX           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for MKX (see all 1546)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 10 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs719477991,2
    C--27699748(+) AAAAT-/AATA  
      TATA
    /T
    ATATA
    2 -- int10--------
    rs1468334571,2
    C--27713965(+) AAAAA-/TCGACT 2 -- int10--------
    rs719962291,2
    C--27725221(+) AAAAA-/GGAGAG 2 -- int10--------
    rs30631911,2
    C--27731941(-) AAAGT-/AA/AAA
            
    AAAAA
    4 -- int1 cds1 trp30--------
    rs28155491,2
    C,F,A--27867646(+) GAAACC/TAGATA 2 -- ds500112Minor allele frequency- N:0.03EA NA CSA WA 584
    rs796776261,2
    F--27867659(+) AATGAC/TTAAGT 2 -- ds50012Minor allele frequency- T:0.04CSA WA 120
    rs1472652961,2
    C--27867750(+) ACAAA-/TAATGC 2 -- ds50010--------
    rs28155501,2
    C,F,A,H--27867788(+) ATTACG/CTGAAA 2 -- ds500123Minor allele frequency- C:0.18NS EA NA WA CSA 2144
    rs28155511,2
    C,F,A,H--27867855(+) GTCTTT/CGAAAG 2 -- ds500127Minor allele frequency- C:0.25NS EA NA CSA WA 2914
    rs47492591,2
    C,F,A,H--27867916(+) ACTCCC/TATATC 2 -- ds500127Minor allele frequency- T:0.20NS EA NA CSA WA 2974

    HapMap Linkage Disequilibrium report for MKX (27961803 - 28034989 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 8 variations for MKX:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2677848CNV Deletion23128226
    esv2734661CNV Deletion23290073
    esv4953CNV Deletion18987735
    esv2734639CNV Deletion23290073
    esv2734650CNV Deletion23290073
    esv2734606CNV Deletion23290073
    nsv831813CNV Loss17160897
    esv7833CNV Loss19470904

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing MKX
    DNA2.0 Custom Variant and Variant Library Synthesis for MKX

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

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    OMIM gene information: 601332    OMIM disorders: --


    Find genes that share disorders with MKX           About GenesLikeMe

    Genetic Association Database (GAD): MKX
    Human Genome Epidemiology (HuGE) Navigator: MKX (1 document)

    Export disorders for MKX gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for MKX gene, integrated from 10 sources (see all 19):
    (articles sorted by number of sources associating them with MKX)
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    1. Maternal genes and facial clefts in offspring: a comprehensive search for genetic associations in two population-based cleft studies from Scandinavia. (PubMed id 20634891)1, 4 Jugessur A....Murray J.C. (PLoS ONE 2010)
    2. Mohawk is a novel homeobox gene expressed in the developing mouse embryo. (PubMed id 16408284)1, 3 Anderson D.M....Rawls A. (Dev. Dyn. 2006)
    3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    4. In silico characterization of an Iroquois family-related homeodomain protein. (PubMed id 16077953)1, 9 Weinmann A....Teufel A. (Int. J. Mol. Med. 2005)
    5. Transcription factor Mohawk and the pathogenesis of human anterior cruciate ligament degradation. (PubMed id 23686683)1 Nakahara H....Asahara H. (Arthritis Rheum. 2013)
    6. Quantitative analysis of HSP90-client interactions reveals principles of substrate recognition. (PubMed id 22939624)1 Taipale M....Lindquist S. (Cell 2012)
    7. Genome-wide association study of antibody response to smallpox vaccine. (PubMed id 22542470)1 Ovsyannikova I.G....Poland G.A. (Vaccine 2012)
    8. The atypical homeodomain transcription factor Mohawk controls tendon morphogenesis. (PubMed id 20696843)1 Liu W....Jiang R. (Mol. Cell. Biol. 2010)
    9. The Mohawk homeobox gene is a critical regulator of tendon differentiation. (PubMed id 20498044)1 Ito Y....Asahara H. (Proc. Natl. Acad. Sci. U.S.A. 2010)
    10. Ubiquitin-mediated proteolysis of HuR by heat shock. (PubMed id 19322201)1 Abdelmohsen K....Gorospe M. (EMBO J. 2009)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
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    Free Text  

      Query String
    PubMed
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 283078 HGNC: 23729 AceView: C10orf48 Ensembl:ENSG00000150051 euGenes: HUgn283078
    ECgene: MKX H-InvDB: MKX

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for MKX Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for MKX gene:
    Search GeneIP for patents involving MKX

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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