MKRN4P Gene
pseudogene GIFtS: 22
GCID: GC0XP040694
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makorin ring finger protein 4, pseudogene(Previous names: makorin, ring finger protein, 4, makorin ring finger protein...)
(Previous symbols: ZNF127L1, MKRN4, MKRNP5)
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Aliases
for MKRN4P gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
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| Makorin Ring Finger Protein 4, Pseudogene1 2 | | ZNF127-Xp2 3 | | MKRN41 2 3 | | Makorin, Ring Finger Protein, 41 | | MKRNP51 2 3 | | EC 6.3.2.-3 | | RNF641 2 3 | | Makorin RING Finger Protein Pseudogene 43 | | ZNF127L11 2 3 | | RING Finger Protein 643 | | ZNF-Xp1 2 | | Zinc Finger Protein 127-Like 13 | | Makorin RING Finger Protein Pseudogene 51 3 | | Zinc Finger Protein 127-Xp3 |
Export aliases for MKRN4P gene to outside databases |
Summaries
for MKRN4P gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
UniProtKB/Swiss-Prot: MKRN4_HUMAN, Q13434Function: May act as a E3 ubiquitin ligase catalyzing the covalent attachment of ubiquitin moieties onto substrateproteins (By similarity)
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Genomic Views
for MKRN4P gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| Regulatory elements:
 Search SABiosciences Regulatory transcription factor binding sites for MKRN4P
Other transcription factors
Search SABiosciences Chromatin IP Primers for MKRN4P
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat MKRN4P |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: Xp21.1 Ensembl cytogenetic band: Xp11.4 HGNC cytogenetic band: Xp21.1MKRN4P Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome X GeneLoc Exon Structure GeneLoc location for GC0XP040694: view genomic region
(about GC identifiers)
Start:
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40,693,397 bp from pter |
End:
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40,697,065 bp from pter |
Size:
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3,669 bases |
Orientation:
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plus strand |
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Proteins
for MKRN4P gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
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UniProtKB/Swiss-Prot: MKRN4_HUMAN, Q13434 (See
protein sequence)Recommended Name: Putative E3 ubiquitin-protein ligase makorin-4 Size: 485 amino acids; 52910 Da
Caution: Could be the product of a pseudogeneExplore the universe of human proteins at neXtProt for MKRN4P: NX_Q13434
MKRN4P Protein expression data from MOPED and PaxDb: --
Human Recombinant Protein Products:
MKRN4P Antibody Products:
Assay Products for MKRN4P: |
Protein
Domains /
Families
for MKRN4P gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
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MKRN4P for domains About GeneDecksing
5 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry Q13434ProtoNet protein and cluster: Q13434 2 Blocks protein families: IPB000571 Zn-finger IPB001841 Zn-finger
UniProtKB/Swiss-Prot: MKRN4_HUMAN, Q13434Similarity: Contains 4 C3H1-type zinc fingersSimilarity: Contains 1 RING-type zinc finger |
Function
for MKRN4P gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
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Function Summary:
UniProtKB/Swiss-Prot: MKRN4_HUMAN, Q13434Function: May act as a E3 ubiquitin ligase catalyzing the covalent attachment of ubiquitin moieties onto substrateproteins (By similarity)Enzyme Number (IUBMB): EC 6.3.2.-1
Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view): About this table
MKRN4P for ontologies About GeneDecksing
1 GenomeRNAi human phenotype for MKRN4P:
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Pathways & Interactions
for MKRN4P gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
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UniProtKB/Swiss-Prot: MKRN4_HUMAN, Q13434Pathway: Protein modification; protein ubiquitinationInteractions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for MKRN4P
Gene Ontology (GO): 1 biological process term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
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| GO:0016567 | protein ubiquitination |
IEA | -- |
MKRN4P for ontologies About GeneDecksing
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Drugs & Compounds
for MKRN4P gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for MKRN4P
Search CenterWatch for drugs/clinical trials and news about MKRN4P 
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Transcripts
for MKRN4P gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
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1 Ensembl transcript including schematic representation, and UCSC links where relevant: ENST00000444706
2 AceView cDNA sequences: NM_030757 BQ072409
GeneLoc Exon Structure
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Expression
for MKRN4P gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| MKRN4P expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: --
About this image SABiosciences Custom PCR Arrays for MKRN4P
Primer
Products: |  | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for MKRN4P
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse / rat MKRN4P | | | Search QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat MKRN4P | | | Search QIAGEN QuantiFast Probe-based Assays in human, mouse, rat MKRN4P |
Orthologs
for MKRN4P gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
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--
ENSEMBL Gene Tree for MKRN4P (if available)
TreeFam Gene Tree for MKRN4P (if available) |
Paralogs
for MKRN4P gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
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Genomic Variants
for MKRN4P gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
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| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr X pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
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HapMap Linkage Disequilibrium report for MKRN4P (40693397 - 40697065 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for MKRN4P: -- | SABiosciences Cancer Mutation PCR Assays |
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Disorders
/ Diseases
for MKRN4P gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
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Publications
for MKRN4P gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
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PubMed article for MKRN4P gene integrated from 9 sources:
(articles sorted by number of sources associating them with MKRN4P) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Systematic and quantitative assessment of the ubiquiti n-modified proteome. (PubMed id 21906983)1 Kim W....Gygi S.P. (2011)
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External Searches for MKRN4P gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
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Genome Databases showing MKRN4P gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
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Other Databases showing MKRN4P gene
(According to HUGE)
About This Section
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Specialized Databases showing MKRN4P gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
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| Name | Description |
| PharmGKB entry for MKRN4P | Pharmacogenomics, SNPs, Pathways |
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About This Section
| Patent Information for MKRN4P gene:
Search GeneIP for patents involving MKRN4P
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for MKRN4P gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
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|  | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat MKRN4P | | | Search QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing MKRN4P | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat MKRN4P | | | Search QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat MKRN4P | | | Search QIAGEN QuantiFast Probe-based Assays in human, mouse, rat MKRN4P | | | Search QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat MKRN4P |
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| | | | Search Tocris compounds for MKRN4P |
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 | | | | |  |  |  | | | | Search ThermoFisher Antibodies for MKRN4P |
| | | Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat MKRN4P |
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