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MKRN3 Gene

protein-coding   GIFtS: 53
GCID: GC15P023810

Makorin Ring Finger Protein 3


(Previous symbols: ZNF127, D15S9)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Makorin Ring Finger Protein 31 2     RING Finger Protein 632 3
ZNF1271 2 3 5     CPPB22 5
D15S91 2 3     ZFP1272 5
Zinc Finger Protein 1271 2 3     Probable E3 Ubiquitin-Protein Ligase Makorin-32
RNF632 3     EC 6.3.2.-3

External Ids:    HGNC: 71141   Entrez Gene: 76812   Ensembl: ENSG000001794557   OMIM: 6038565   UniProtKB: Q130643   

Export aliases for MKRN3 gene to outside databases

Previous GC identifers: GC15U990051 GC15P016700 GC15P021228 GC15P021358 GC15P021361 GC15P001945


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for MKRN3 Gene:
The protein encoded by this gene contains a RING (C3HC4) zinc finger motif and several C3H zinc finger motifs.
This gene is intronless and imprinted, with expression only from the paternal allele. Disruption of the
imprinting at this locus may contribute to Prader-Willi syndrome. An antisense RNA of unknown function has been
found overlapping this gene. (provided by RefSeq, Jul 2008)

GeneCards Summary for MKRN3 Gene:
MKRN3 (makorin ring finger protein 3) is a protein-coding gene. Diseases associated with MKRN3 include precocious puberty, central, 2, and idiopathic central precocious puberty. GO annotations related to this gene include ligase activity. An important paralog of this gene is MKRN2.

UniProtKB/Swiss-Prot: MKRN3_HUMAN, Q13064
Function: E3 ubiquitin ligase catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins (By
similarity)




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000015.10  NC_018926.2  NT_010194.18  
Regulatory elements:
   Regulatory transcription factor binding sites in the MKRN3 gene promoter:
         AML1a   Pax-6   POU3F2 (N-Oct-5a)   POU3F2 (N-Oct-5b)   POU3F2   C/EBPalpha   HEN1   FOXO1a   NF-kappaB1   FOXO1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidMKRN3 promoter sequence
   Search Chromatin IP Primers for MKRN3

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat MKRN3


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 15q11-q13   Ensembl cytogenetic band:  15q11.2   HGNC cytogenetic band: 15q11-q13

MKRN3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
MKRN3 gene location

GeneLoc information about chromosome 15         GeneLoc Exon Structure

GeneLoc location for GC15P023810:  view genomic region     (about GC identifiers)

Start:
23,810,454 bp from pter      End:
23,873,064 bp from pter
Size:
62,611 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: MKRN3_HUMAN, Q13064 (See protein sequence)
Recommended Name: Probable E3 ubiquitin-protein ligase makorin-3  
Size: 507 amino acids; 55645 Da
Miscellaneous: Imprinted, expressed from the paternal chromosome only. A deficiency of MKRN3 is not sufficient to
cause Prader-Willi syndrome (PWS)

Explore the universe of human proteins at neXtProt for MKRN3: NX_Q13064

Explore proteomics data for MKRN3 at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys398
  • Modification sites at PhosphoSitePlus

  • See MKRN3 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_005655.1  
    ENSEMBL proteins: 
     ENSP00000457884   ENSP00000456779   ENSP00000455368   ENSP00000313881  

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    RNF: RING-type (C3HC4) zinc fingers

    Selected InterPro protein domains (see all 7):
     IPR000571 Znf_CCCH
     IPR001841 Znf_RING
     IPR026294 Makorin_3
     IPR013083 Znf_RING/FYVE/PHD
     IPR017907 Znf_RING_CS

    Graphical View of Domain Structure for InterPro Entry Q13064

    ProtoNet protein and cluster: Q13064

    2 Blocks protein domains:
    IPB000571 Zn-finger
    IPB001841 Zn-finger


    UniProtKB/Swiss-Prot: MKRN3_HUMAN, Q13064
    Similarity: Contains 3 C3H1-type zinc fingers
    Similarity: Contains 1 RING-type zinc finger


    MKRN3 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: MKRN3_HUMAN, Q13064
    Function: E3 ubiquitin ligase catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins (By
    similarity)

         Genatlas biochemistry entry for MKRN3:
    makorin,ring finger protein,3,associated with a nuclear matrix attachment sequence (MAR),ubiquitously expressed
    from the paternal allele (maternally imprinted),mediating ubiquitin-conjugating enzyme (E2)-dependent
    ubiquitination

         Enzyme Number (IUBMB): EC 6.3.2.-1

         Gene Ontology (GO): 4 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding IPI--
    GO:0008270zinc ion binding IEA--
    GO:0016874ligase activity IEA--
    GO:0046872metal ion binding ----
         
    MKRN3 for ontologies           About GeneDecksing


    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for MKRN3
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    hsa-miR-30c hsa-miR-607 hsa-miR-30d hsa-miR-519a hsa-miR-1297 hsa-miR-570 hsa-miR-30a hsa-miR-4325
    SwitchGear 3'UTR luciferase reporter plasmidMKRN3 3' UTR sequence
    Inhib. RNA
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus3
    cytosol2
    plasma membrane1

    Gene Ontology (GO): 1 cellular component term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0030529ribonucleoprotein complex TAS10196367

    MKRN3 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    UniProtKB/Swiss-Prot: MKRN3_HUMAN, Q13064
    Pathway: Protein modification; protein ubiquitination

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for MKRN3
    Interactions:

        Search GeneGlobe Interaction Network for MKRN3

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for MKRN3 (Q130641, 3 ENSP000003138814) via UniProtKB, MINT, STRING, and/or I2D (see all 36)

    InteractantInteraction Details
    GeneCardExternal ID(s)
    TSG101Q998163, ENSP000002519684I2D: score=2 STRING: ENSP00000251968
    UBE2D2P628373, ENSP000003817174I2D: score=2 STRING: ENSP00000381717
    UBE2D3P610773, ENSP000003497224I2D: score=2 STRING: ENSP00000349722
    UBE2IP632793, ENSP000003248974I2D: score=2 STRING: ENSP00000324897
    UBE2NP610883, ENSP000003161764I2D: score=2 STRING: ENSP00000316176
    About this table

    Gene Ontology (GO): 1 biological process term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0016567protein ubiquitination IEA--

    MKRN3 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for MKRN3



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for MKRN3 gene: 
    NM_005664.3  

    Unigene Cluster for MKRN3:

    Makorin ring finger protein 3
    Hs.72964  [show with all ESTs]
    Unigene Representative Sequence: NM_005664
    5 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000570112 ENST00000568252(uc001ywi.3) ENST00000564592(uc010ayi.1)
    ENST00000568945 ENST00000314520(uc001ywh.4)
    miRNA
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    hsa-miR-30c hsa-miR-607 hsa-miR-30d hsa-miR-519a hsa-miR-1297 hsa-miR-570 hsa-miR-30a hsa-miR-4325
    SwitchGear 3'UTR luciferase reporter plasmidMKRN3 3' UTR sequence
    Inhib. RNA
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    Primer
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    OriGene qPCR primer pairs and template standards for MKRN3
    OriGene qSTAR qPCR primer pairs in human, mouse for MKRN3
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat MKRN3
      QuantiTect SYBR Green Assays in human, mouse, rat MKRN3
      QuantiFast Probe-based Assays in human, mouse, rat MKRN3

    Additional mRNA sequence: 

    AK309383.1 BC044639.1 

    3 DOTS entries:

    DT.206625  DT.121017966  DT.121017976 

    17 AceView cDNA sequences:

    AI939624 BC070293 AI494223 BC044639 BG056640 AA310871 NM_005664 BG481814 
    AI497659 BG621437 BE728344 BQ226594 BF307979 AI936618 AW445166 BE903470 
    AW952653 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    MKRN3 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: AAATAATTTA
    MKRN3 Expression
    About this image


    MKRN3 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 2) fully expand
     
     Gut Tube (Gastrointestinal Tract)    fully expand to see all 2 entries
             Foregut
     
     Eye (Sensory Organs)
             Retina
    MKRN3 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    MKRN3 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.72964

    UniProtKB/Swiss-Prot: MKRN3_HUMAN, Q13064
    Tissue specificity: Ubiquitous

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    In Situ
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for MKRN3 gene from Selected species (see all 13)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Mkrn31 , 5 makorin, ring finger protein, 31, 5 76.67(n)1
    67.92(a)1
      7 (34.37 cM)5
    226521  NM_011746.21  NP_035876.21 
     624175935 
    chicken
    (Gallus gallus)
    Aves MKRN16
    Gallus gallus makorin ring finger protein 1 (MKRN1...
    49(a)
    1 → many
    1(56931062-56952880)
    lizard
    (Anolis carolinensis)
    Reptilia --
    Uncharacterized protein
    48(a)
    many ↔ many
    5(15411205-15441612)
    zebrafish
    (Danio rerio)
    Actinopterygii mkrn16
    makorin, ring finger protein, 1
    45(a)
    many ↔ many
    4(11356798-11372358) ENSDARG00000041665
    fruit fly
    (Drosophila melanogaster)
    Insecta CG124773   -- 50(a)
    (best of 4)
      75D7   --
    worm
    (Caenorhabditis elegans)
    Secernentea Y55F3AM.66
    Protein Y55F3AM.6, isoform b (Y55F3AM.6) mRNA, com...
    29(a)
    1 → many
    IV(992289-997652) WBGene00021924


    ENSEMBL Gene Tree for MKRN3 (if available)
    TreeFam Gene Tree for MKRN3 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for MKRN3 gene
    MKRN22  MKRN12  
    3 SIMAP similar genes for MKRN3 using alignment to 4 protein entries:     MKRN3_HUMAN (see all proteins):
    MKRN1    MKRN4P    MKRN2

    MKRN3 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for MKRN3 (see all 144)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 15 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0359564
    A colorectal cancer sample4--see VAR_0359562 S T mis40--------
    VAR_0359554
    A colorectal cancer sample4--see VAR_0359552 T M mis40--------
    VAR_0701034
    Precocious puberty, central 2 (CPPB2)4--see VAR_0701032 R S mis40--------
    rs1450482771,2
    --3802959(+) TAATTG/TTATAT 1 -- us2k10--------
    rs1489609311,2
    C--3803483(+) TTGGAC/G/TTCCTG 1 -- us2k10--------
    rs1436381161,2
    --3803644(+) ATACAA/GATTTT 1 -- us2k10--------
    rs1480897731,2
    C--3803655(+) TTTTGC/TCTTTA 1 -- us2k10--------
    rs1866079811,2
    --3803741(+) CCATAC/TTCACA 1 -- us2k10--------
    rs1419734761,2
    --3803832(+) CCTAAC/TTTTGT 1 -- us2k10--------
    rs1917797141,2
    --3804178(+) AAAGAA/GACTTA 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for MKRN3 (23810454 - 23873064 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 3 variations for MKRN3:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv832931CNV Gain17160897
    nsv903594CNV Gain21882294
    dgv699e1CNV Complex17122850

    Human Gene Mutation Database (HGMD): MKRN3
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing MKRN3
    DNA2.0 Custom Variant and Variant Library Synthesis for MKRN3

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 603856   
    OMIM disorders: 615346  
    UniProtKB/Swiss-Prot: MKRN3_HUMAN, Q13064
  • Precocious puberty, central 2 (CPPB2) [MIM:615346]: A condition defined as the development of secondary
    sexual characteristics in boys and girls at a chronological age that is 2.5 standard deviations below the mean
    age at onset of puberty in the population. Central precocious puberty results from premature activation of the
    hypothalamic-pituitary-gonadal axis. Note=The disease is caused by mutations affecting the gene represented in
    this entry

  • 11 diseases for MKRN3:    
    About MalaCards
    precocious puberty, central, 2    idiopathic central precocious puberty    canavan disease    prader-willi syndrome
    central precocious puberty    precocious puberty    intellectual disability    angelman syndrome
    breast and colorectal cancer    cervicitis    colorectal cancer

    2 diseases from the University of Copenhagen DISEASES database for MKRN3:
    Prader-Willi syndrome     Angelman syndrome

    MKRN3 for disorders           About GeneDecksing


    Export disorders for MKRN3 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for MKRN3 gene, integrated from 10 sources (see all 14):
    (articles sorted by number of sources associating them with MKRN3)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. A novel imprinted gene, encoding a RING zinc-finger protein, and overlapping antisense transcript in the Prader-Willi syndrome critical region. (PubMed id 10196367)1, 2, 3 Jong M.T.C....Nicholls R.D. (Hum. Mol. Genet. 1999)
    2. Central precocious puberty caused by mutations in the imprinted gene MKRN3. (PubMed id 23738509)1, 2 Abreu A.P....Kaiser U.B. (N. Engl. J. Med. 2013)
    3. A paternal deletion of MKRN3, MAGEL2 and NDN does not result in Prader-Willi syndrome. (PubMed id 19066619)1, 2 Kanber D.... Buiting K. (Eur. J. Hum. Genet. 2009)
    4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    5. Systematic analysis of dimeric E3-RING interactions reveals increased combinatorial complexity in human ubiquitination networks. (PubMed id 22493164)1 Woodsmith J....Sanderson C.M. (amp 2012)
    6. Systems-wide analysis of ubiquitylation dynamics reveals a key role for PAF15 ubiquitylation in DNA-damage bypass. (PubMed id 23000965)1 Povlsen L.K....Choudhary C. (Nat. Cell Biol. 2012)
    7. A whole genome screen for HIV restriction factors. (PubMed id 22082156)1 Liu L....McKnight A. (Retrovirology 2011)
    8. Analysis of the human E2 ubiquitin conjugating enzyme protein interaction network. (PubMed id 19549727)1 Markson G....Sanderson C.M. (Genome Res. 2009)
    9. Genomic imprinting disorders in humans: a mini-review. (PubMed id 19844787)1 Butler M.G. (J. Assist. Reprod. Genet. 2009)
    10. The consensus coding sequences of human breast and colorectal cancers. (PubMed id 16959974)2 Sjoeblom T.... Velculescu V.E. (Science 2006)

    (in PubMed, OMIM, and NCBI Bookshelf)
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 7681 HGNC: 7114 AceView: MKRN3 Ensembl:ENSG00000179455 euGenes: HUgn7681
    ECgene: MKRN3 H-InvDB: MKRN3

    (According to HUGE)
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    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for MKRN3 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
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    Patent Information for MKRN3 gene:
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