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MKRN2 Gene

protein-coding   GIFtS: 57
GCID: GC03P012598

Makorin Ring Finger Protein 2

Microbiology & Infectious Diseases Congress
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Makorin Ring Finger Protein 21 2
RNF622 3
RING Finger Protein 622 3
Makorin RING Zinc-Finger Protein 22
Probable E3 Ubiquitin-Protein Ligase Makorin-22
EC 6.3.2.-3

External Ids:    HGNC: 71131   Entrez Gene: 236092   Ensembl: ENSG000000759757   OMIM: 6084265   UniProtKB: Q9H0003   

Export aliases for MKRN2 gene to outside databases

Previous GC identifers: GC03P012527 GC03P012573 GC03P012533


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for MKRN2 Gene:
This gene encodes a probable E3 ubiquitin ligase containing several zinc finger domains, that is a member of the
makorin RING zinc-finger protein family. This gene overlaps the v-raf-1 murine leukemia viral oncogene homolog 1
(RAF1) gene in an antisense orientation and may have a co-regulatory function with RAF1. Alternative splicing
results in multiple transcript variants. (provided by RefSeq, Nov 2012)

GeneCards Summary for MKRN2 Gene:
MKRN2 (makorin ring finger protein 2) is a protein-coding gene. Diseases associated with MKRN2 include leukemia, and chronic lymphocytic leukemia. GO annotations related to this gene include ligase activity. An important paralog of this gene is MKRN3.

UniProtKB/Swiss-Prot: MKRN2_HUMAN, Q9H000
Function: E3 ubiquitin ligase catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins (By
similarity)




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000003.12  NC_018914.2  NT_022517.19  
Regulatory elements:
   Regulatory transcription factor binding sites in the MKRN2 gene promoter:
         FOXF2   Nkx2-2   Bach2   POU3F2   FOXC1   IRF-7A   FOXO1a   NF-kappaB1   Pax-4a   FOXO1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidMKRN2 promoter sequence
   Search Chromatin IP Primers for MKRN2

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat MKRN2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 3p25   Ensembl cytogenetic band:  3p25.2   HGNC cytogenetic band: 3p25

MKRN2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
MKRN2 gene location

GeneLoc information about chromosome 3         GeneLoc Exon Structure

GeneLoc location for GC03P012598:  view genomic region     (about GC identifiers)

Start:
12,598,513 bp from pter      End:
12,625,212 bp from pter
Size:
26,700 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: MKRN2_HUMAN, Q9H000 (See protein sequence)
Recommended Name: Probable E3 ubiquitin-protein ligase makorin-2  
Size: 416 amino acids; 46940 Da
Miscellaneous: Partially overlaps and is antisense to the RAF1 proto-oncogene
Secondary accessions: A6NIA2 B3KRC5 Q8N391 Q96BD4 Q9BUY2 Q9NRY1

Explore the universe of human proteins at neXtProt for MKRN2: NX_Q9H000

Explore proteomics data for MKRN2 at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys42, Lys334
  • Modification sites at PhosphoSitePlus

  • See MKRN2 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_001258636.1  NP_054879.3  

    ENSEMBL proteins: 
     ENSP00000170447   ENSP00000396340   ENSP00000397983  

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    RNF: RING-type (C3HC4) zinc fingers

    Selected InterPro protein domains (see all 7):
     IPR000571 Znf_CCCH
     IPR001841 Znf_RING
     IPR026293 Makorin_2
     IPR013083 Znf_RING/FYVE/PHD
     IPR017907 Znf_RING_CS

    Graphical View of Domain Structure for InterPro Entry Q9H000

    ProtoNet protein and cluster: Q9H000

    2 Blocks protein domains:
    IPB000571 Zn-finger
    IPB001841 Zn-finger


    UniProtKB/Swiss-Prot: MKRN2_HUMAN, Q9H000
    Similarity: Contains 4 C3H1-type zinc fingers
    Similarity: Contains 1 RING-type zinc finger


    MKRN2 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: MKRN2_HUMAN, Q9H000
    Function: E3 ubiquitin ligase catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins (By
    similarity)

         Enzyme Number (IUBMB): EC 6.3.2.-1

         Gene Ontology (GO): Selected molecular function terms (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003674molecular_function ND--
    GO:0005515protein binding IPI17500595
    GO:0008270zinc ion binding IEA--
    GO:0016874ligase activity IEA--
    GO:0044822poly(A) RNA binding IDA--
         
    MKRN2 for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for MKRN2:
     Decreased p24 protein expressi 

         1 MGI phenotypic allele for Mkrn2 (no phenotypes)

    MKRN2 for phenotypes           About GeneDecksing

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for MKRN2
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for MKRN2

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for MKRN2
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for MKRN2

    miRNA
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    miRTarBase miRNAs that target MKRN2:
    hsa-mir-92a-3p (MIRT049766), hsa-let-7b-5p (MIRT032377), hsa-mir-130b-3p (MIRT020253), hsa-mir-484 (MIRT042305)

    Block miRNA regulation of human, mouse, rat MKRN2 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate MKRN2 (see all 25):
    hsa-miR-548j hsa-miR-3200-5p hsa-miR-137 hsa-miR-548i hsa-miR-4275 hsa-miR-9 hsa-miR-629 hsa-miR-548a-5p
    SwitchGear 3'UTR luciferase reporter plasmidMKRN2 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for MKRN2
    Predesigned siRNA for gene silencing in human, mouse, rat MKRN2

    Gene Editing
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    OriGene ORF clones in mouse, rat for MKRN2
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: MKRN2 (NM_014160)
    Sino Biological Human cDNA Clone for MKRN2
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for MKRN2
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MKRN2

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    Browse ESI BIO Cell Lines and PureStem Progenitors for MKRN2 
    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MKRN2


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus3
    cytosol2

    Gene Ontology (GO): 1 cellular component term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005622intracellular IDA11597136

    MKRN2 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    UniProtKB/Swiss-Prot: MKRN2_HUMAN, Q9H000
    Pathway: Protein modification; protein ubiquitination

        Pathway & Disease-focused RT2 Profiler PCR Array including MKRN2: 

              Ubiquitin Ligases in human mouse rat

    Interactions:

        Search GeneGlobe Interaction Network for MKRN2

    STRING Interaction Network Preview (showing 5 interactants - click image to see 24)

    Selected Interacting proteins for MKRN2 (Q9H0003 ENSP000001704474) via UniProtKB, MINT, STRING, and/or I2D (see all 25)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    UBE2KP610863, ENSP000002614274I2D: score=1 STRING: ENSP00000261427
    RBCK1ENSP000003486324STRING: ENSP00000348632
    CPSF1ENSP000003393534STRING: ENSP00000339353
    UBCENSP000003448184STRING: ENSP00000344818
    RBBP6ENSP000003178724STRING: ENSP00000317872
    About this table

    Gene Ontology (GO): 2 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0008150biological_process ND--
    GO:0016567protein ubiquitination IEA--

    MKRN2 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for MKRN2



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for MKRN2 gene (2 alternative transcripts): 
    NM_001271707.1  NM_014160.4  

    Unigene Cluster for MKRN2:

    Makorin ring finger protein 2
    Hs.591666  [show with all ESTs]
    Unigene Representative Sequence: NM_014160
    3 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000170447(uc003bxd.3 uc011aus.2) ENST00000411987 ENST00000448482

    Congresses - knowledge worth sharing:
    European Congress of Clinical Microbiology and Infectious Diseases (ECCMID) 10 - 13 May 2014

    miRNA
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    Block miRNA regulation of human, mouse, rat MKRN2 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate MKRN2 (see all 25):
    hsa-miR-548j hsa-miR-3200-5p hsa-miR-137 hsa-miR-548i hsa-miR-4275 hsa-miR-9 hsa-miR-629 hsa-miR-548a-5p
    SwitchGear 3'UTR luciferase reporter plasmidMKRN2 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for MKRN2
    Predesigned siRNA for gene silencing in human, mouse, rat MKRN2
    Clone
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    OriGene clones in human, mouse for MKRN2 (see all 7)
    OriGene ORF clones in mouse, rat for MKRN2
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: MKRN2 (NM_014160)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for MKRN2
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MKRN2
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for MKRN2
    OriGene qSTAR qPCR primer pairs in human, mouse for MKRN2
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat MKRN2
      QuantiTect SYBR Green Assays in human, mouse, rat MKRN2
      QuantiFast Probe-based Assays in human, mouse, rat MKRN2

    Additional mRNA sequence: 

    AF302084.1 AK091318.1 AK298463.1 AL834512.1 BC001799.2 BC015715.1 

    12 DOTS entries:

    DT.92451812  DT.100669838  DT.100669840  DT.95208619  DT.92451816  DT.100669851  DT.100669848  DT.120918125 
    DT.120918142  DT.120918155  DT.87008986  DT.97769875 

    Selected AceView cDNA sequences (see all 275):

    AL515366 BC001799 BI831529 AA047830 AL523490 BM804239 CB124514 R26687 
    BI752660 AA383521 AL533670 AL834512 AI360908 CA417184 BG824733 BE644801 
    AA325297 CD366490 BE502908 CA773473 BG248241 BX280852 BM480081 AI651914 

    GeneLoc Exon Structure

    4 Alternative Splicing Database (ASD) splice patterns (SP) for MKRN2    About this scheme

    ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4a · 4b ^ 5a · 5b ^ 6 ^ 7a · 7b ^ 8 ^ 9
    SP1:                    -                                                               
    SP2:                                                                                    
    SP3:                    -                 -     -     -                                 
    SP4:                    -     -                                                         


    ECgene alternative splicing isoforms for MKRN2

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    MKRN2 expression in normal human tissues (normalized intensities)      MKRN2 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GCACCCAAGG
    MKRN2 Expression
    About this image


    MKRN2 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 7) fully expand
     
     Brain (Nervous System)    fully expand to see all 4 entries
             Cerebral Cortex
     
     Testis (Reproductive System)
             Leydig Cells Testis Interstitium
     
     Trophoblast (Extraembryonic Tissues)
             Trophoblast Cells Trophoblast
     
     Ovary (Reproductive System)
             Oviduct
     
     Liver (Hepatobiliary System)
             Hepatocytes Liver Lobule
    MKRN2 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    MKRN2 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.591666

    UniProtKB/Swiss-Prot: MKRN2_HUMAN, Q9H000
    Tissue specificity: Widely expressed

        Pathway & Disease-focused RT2 Profiler PCR Array including MKRN2: 
              Ubiquitin Ligases in human mouse rat

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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MKRN2

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of eukaryotes.

    Orthologs for MKRN2 gene from Selected species (see all 17)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Mkrn21 , 5 makorin, ring finger protein, 21, 5 85.1(n)1
    88.46(a)1
      6 (53.61 cM)5
    670271  NM_023290.21  NP_075779.21 
     1156019385 
    chicken
    (Gallus gallus)
    Aves MKRN21 makorin ring finger protein 2 73.41(n)
    75.12(a)
      374162  NM_204288.1  NP_989619.1 
    lizard
    (Anolis carolinensis)
    Reptilia MKRN26
    makorin ring finger protein 2
    73(a)
    1 ↔ 1
    2(158935445-158957033)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.161552 Xenopus laevis transcribed sequence with moderate similarity more 75(n)    BJ081466.1 
    zebrafish
    (Danio rerio)
    Actinopterygii mkrn22 makorin, ring finger protein, 2 74.41(n)   170783  AF277172.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG124773   -- 45(a)
    (best of 4)
      75D7   --
    worm
    (Caenorhabditis elegans)
    Secernentea Y55F3AM.66
    Protein Y55F3AM.6, isoform b (Y55F3AM.6) mRNA, com...
    31(a)
    1 → many
    IV(992289-997652) WBGene00021924
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons AT3G085051 AT3G08505 49.47(n)
    40.71(a)
      819998  NM_202526.1  NP_974255.1 
    rice
    (Oryza sativa)
    Liliopsida Os06g03187001 Os06g0318700 49.14(n)
    39.71(a)
      4340884  NM_001064040.1  NP_001057505.1 


    ENSEMBL Gene Tree for MKRN2 (if available)
    TreeFam Gene Tree for MKRN2 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for MKRN2 gene
    MKRN32  MKRN12  
    3 SIMAP similar genes for MKRN2 using alignment to 3 protein entries:     MKRN2_HUMAN (see all proteins):
    MKRN1    MKRN4P    MKRN3

    MKRN2 for paralogs           About GeneDecksing


    1 Pseudogenes.org Pseudogene for MKRN2
    PGOHUM00000243604


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for MKRN2 (see all 703)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 3 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1835689711,2
    --12596549(+) CTCGCC/TCGTAA 2 -- us2k10--------
    rs25968221,2
    C,F,O,A,H--12596844(-) TGCTCG/ATAAAA 2 -- us2k1 tfbs331Minor allele frequency- A:0.49NA NS EA WA CSA 2729
    rs353321441,2
    C,F--12596999(+) AAGACT/CCAATA 2 -- us2k15Minor allele frequency- C:0.12NA CSA WA 243
    rs1878134211,2
    --12597048(+) ATACAA/TAACAT 2 -- us2k10--------
    rs1385425131,2
    C--12597148(+) TTAAAC/GTAATT 2 -- us2k10--------
    rs1438044161,2
    --12597199(+) GTATTG/TCCTGG 2 -- us2k10--------
    rs1915680061,2
    --12597202(+) TTGCCA/TGGGAA 2 -- us2k10--------
    rs1845386041,2
    --12597212(+) AGGACA/CATAAG 2 -- us2k10--------
    rs343982371,2
    C,F,H--12597248(+) ATCCAG/ACCCCC 2 -- us2k117Minor allele frequency- A:0.13NS EA NA CSA WA 2217
    rs1874391761,2
    --12597250(+) CCAGCC/TCCCAC 2 -- us2k10--------

    HapMap Linkage Disequilibrium report for MKRN2 (12598513 - 12625212 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 7 variations for MKRN2:    About this table    
    Variant IDTypeSubtypePubMed ID
    dgv850e199CNV Deletion23128226
    dgv810e201CNV Deletion23290073
    nsv512796CNV Insertion21212237
    nsv876541CNV Gain21882294
    esv2751977CNV Gain17911159
    dgv597n27CNV Gain19166990
    nsv7351OTHER Inversion18451855

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 608426    OMIM disorders: --

    3 diseases for MKRN2:    About MalaCards
    leukemia    chronic lymphocytic leukemia    hiv-1


    MKRN2 for disorders           About GeneDecksing


    Congresses - knowledge worth sharing:
    The International Symposium on Pneumococci and Pneumococcal Diseases (ISPPD) 9 - 13 March 2014
    Genetic Association Database (GAD): MKRN2
    Human Genome Epidemiology (HuGE) Navigator: MKRN2 (2 documents)

    Export disorders for MKRN2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for MKRN2 gene, integrated from 10 sources (see all 21):
    (articles sorted by number of sources associating them with MKRN2)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Phylogenetic conservation of the makorin-2 gene, encoding a multiple zinc-finger protein, antisense to the raf1 proto-oncogene. (PubMed id 11597136)1, 2, 3, 9 Gray T.A.... Nicholls R.D. (Genomics 2001)
    2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    4. Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells. (PubMed id 11042152)1, 2 Zhang Q.-H.... Chen Z. (Genome Res. 2000)
    5. Systematic analysis of dimeric E3-RING interactions reveals increased combinatorial complexity in human ubiquitination networks. (PubMed id 22493164)1 Woodsmith J....Sanderson C.M. (amp 2012)
    6. Systems-wide analysis of ubiquitylation dynamics reveals a key role for PAF15 ubiquitylation in DNA-damage bypass. (PubMed id 23000965)1 Povlsen L.K....Choudhary C. (Nat. Cell Biol. 2012)
    7. Methods for quantification of in vivo changes in protein ubiquitination following proteasome and deubiquitinase inhibition. (PubMed id 22505724)1 Udeshi N.D....Carr S.A. (amp 2012)
    8. Single nucleotide polymorphisms of matrix metalloproteinase 9 (MMP9) and tumor protein 73 (TP73) interact with Epstein-Barr virus in chronic lymphocytic leukemia: results from the European case-control study EpiLymph. (PubMed id 21048031)1 Casabonne D....de Sanjose S. (Haematologica 2011)
    9. Activity-based chemical proteomics accelerates inhibitor development for deubiquitylating enzymes. (PubMed id 22118674)1 Altun M....Kessler B.M. (amp 2011)
    10. Mass spectrometric analysis of lysine ubiquitylation reveals promiscuity at site level. (PubMed id 21139048)1 Danielsen J.M....Nielsen M.L. (amp 2011)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 23609 HGNC: 7113 AceView: MKRN2 Ensembl:ENSG00000075975 euGenes: HUgn23609
    ECgene: MKRN2 H-InvDB: MKRN2

    (According to HUGE)
    About This Section

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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for MKRN2 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

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    Patent Information for MKRN2 gene:
    Search GeneIP for patents involving MKRN2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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