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Aliases for MKRN2 Gene

Aliases for MKRN2 Gene

  • Makorin Ring Finger Protein 2 2 3 5
  • RING Finger Protein 62 3 4
  • RNF62 3 4
  • Makorin RING Zinc-Finger Protein 2 3
  • EC 6.3.2.- 4
  • HSPC070 3

External Ids for MKRN2 Gene

Previous GeneCards Identifiers for MKRN2 Gene

  • GC03P012527
  • GC03P012573
  • GC03P012533
  • GC03P012598

Summaries for MKRN2 Gene

Entrez Gene Summary for MKRN2 Gene

  • This gene encodes a probable E3 ubiquitin ligase containing several zinc finger domains, that is a member of the makorin RING zinc-finger protein family. This gene overlaps the v-raf-1 murine leukemia viral oncogene homolog 1 (RAF1) gene in an antisense orientation and may have a co-regulatory function with RAF1. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2012]

GeneCards Summary for MKRN2 Gene

MKRN2 (Makorin Ring Finger Protein 2) is a Protein Coding gene. GO annotations related to this gene include poly(A) RNA binding and ligase activity. An important paralog of this gene is MKRN3.

UniProtKB/Swiss-Prot for MKRN2 Gene

  • E3 ubiquitin ligase catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MKRN2 Gene

Genomics for MKRN2 Gene

Regulatory Elements for MKRN2 Gene

Enhancers for MKRN2 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around MKRN2 on UCSC Golden Path with GeneCards custom track

Promoters for MKRN2 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around MKRN2 on UCSC Golden Path with GeneCards custom track

Genomic Location for MKRN2 Gene

12,557,014 bp from pter
12,583,713 bp from pter
26,700 bases
Plus strand

Genomic View for MKRN2 Gene

Genes around MKRN2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MKRN2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MKRN2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MKRN2 Gene

Proteins for MKRN2 Gene

  • Protein details for MKRN2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Probable E3 ubiquitin-protein ligase makorin-2
    Protein Accession:
    Secondary Accessions:
    • A6NIA2
    • B3KRC5
    • B4DPR4
    • Q8N391
    • Q96BD4
    • Q9BUY2
    • Q9NRY1

    Protein attributes for MKRN2 Gene

    416 amino acids
    Molecular mass:
    46940 Da
    Quaternary structure:
    No Data Available
    • Partially overlaps and is antisense to the RAF1 proto-oncogene.

    Alternative splice isoforms for MKRN2 Gene


neXtProt entry for MKRN2 Gene

Proteomics data for MKRN2 Gene at MOPED

Post-translational modifications for MKRN2 Gene

  • Ubiquitination at Lys 42 and Lys 334
  • Modification sites at PhosphoSitePlus

Other Protein References for MKRN2 Gene

No data available for DME Specific Peptides for MKRN2 Gene

Domains & Families for MKRN2 Gene

Gene Families for MKRN2 Gene

Suggested Antigen Peptide Sequences for MKRN2 Gene

Graphical View of Domain Structure for InterPro Entry



  • Contains 4 C3H1-type zinc fingers.
  • Contains 4 C3H1-type zinc fingers.
  • Contains 1 RING-type zinc finger.
genes like me logo Genes that share domains with MKRN2: view

Function for MKRN2 Gene

Molecular function for MKRN2 Gene

UniProtKB/Swiss-Prot Function:
E3 ubiquitin ligase catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins.

Enzyme Numbers (IUBMB) for MKRN2 Gene

Gene Ontology (GO) - Molecular Function for MKRN2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 17500595
GO:0008270 zinc ion binding IEA --
GO:0016874 ligase activity IEA --
genes like me logo Genes that share ontologies with MKRN2: view
genes like me logo Genes that share phenotypes with MKRN2: view

Animal Model Products

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for MKRN2 Gene

Localization for MKRN2 Gene

Subcellular locations from

Jensen Localization Image for MKRN2 Gene COMPARTMENTS Subcellular localization image for MKRN2 gene
Compartment Confidence
nucleus 4
cytosol 3

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for MKRN2 Gene

Pathways & Interactions for MKRN2 Gene

SuperPathways for MKRN2 Gene

No Data Available

UniProtKB/Swiss-Prot Q9H000-MKRN2_HUMAN

  • Pathway: Protein modification; protein ubiquitination.

Gene Ontology (GO) - Biological Process for MKRN2 Gene


No data available for Pathways by source and SIGNOR curated interactions for MKRN2 Gene

Drugs & Compounds for MKRN2 Gene

No Compound Related Data Available

Transcripts for MKRN2 Gene

Unigene Clusters for MKRN2 Gene

Makorin ring finger protein 2:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for MKRN2 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4a · 4b ^ 5a · 5b ^ 6 ^ 7a · 7b ^ 8 ^ 9
SP1: -
SP3: - - - -
SP4: - -

Relevant External Links for MKRN2 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for MKRN2 Gene

mRNA expression in normal human tissues for MKRN2 Gene

Protein differential expression in normal tissues from HIPED for MKRN2 Gene

This gene is overexpressed in Peripheral blood mononuclear cells (17.7), Fetal Brain (10.2), and Pancreas (7.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for MKRN2 Gene

SOURCE GeneReport for Unigene cluster for MKRN2 Gene Hs.591666

mRNA Expression by UniProt/SwissProt for MKRN2 Gene

Tissue specificity: Widely expressed.
genes like me logo Genes that share expression patterns with MKRN2: view

Protein tissue co-expression partners for MKRN2 Gene

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA differential expression in normal tissues for MKRN2 Gene

Orthologs for MKRN2 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for MKRN2 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia MKRN2 35
  • 85.06 (n)
  • 88.67 (a)
MKRN2 36
  • 85 (a)
(Canis familiaris)
Mammalia MKRN2 35
  • 90.38 (n)
  • 93.51 (a)
MKRN2 36
  • 94 (a)
(Mus musculus)
Mammalia Mkrn2 35
  • 85.1 (n)
  • 88.46 (a)
Mkrn2 16
Mkrn2 36
  • 88 (a)
(Pan troglodytes)
Mammalia MKRN2 35
  • 99.2 (n)
  • 99.52 (a)
MKRN2 36
  • 100 (a)
(Rattus norvegicus)
Mammalia Mkrn2 35
  • 85.82 (n)
  • 88.7 (a)
(Monodelphis domestica)
Mammalia MKRN2 36
  • 82 (a)
(Ornithorhynchus anatinus)
Mammalia MKRN2 36
  • 57 (a)
(Gallus gallus)
Aves MKRN2 35
  • 73.41 (n)
  • 75.12 (a)
MKRN2 36
  • 74 (a)
(Anolis carolinensis)
Reptilia MKRN2 36
  • 73 (a)
African clawed frog
(Xenopus laevis)
Amphibia Xl.16155 35
(Danio rerio)
Actinopterygii mkrn2 35
  • 62.18 (n)
  • 62.59 (a)
mkrn2 36
  • 59 (a)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.2238 35
fruit fly
(Drosophila melanogaster)
Insecta CG12477 37
  • 45 (a)
CG5334 37
  • 42 (a)
CG5347 37
  • 37 (a)
Mkrn1 37
  • 33 (a)
CG12477 36
  • 29 (a)
CG5334 36
  • 39 (a)
CG5347 36
  • 40 (a)
Mkrn1 36
  • 33 (a)
(Caenorhabditis elegans)
Secernentea Y55F3AM.6 36
  • 31 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes LEE1 38
thale cress
(Arabidopsis thaliana)
eudicotyledons AT3G08505 35
  • 49.47 (n)
  • 40.71 (a)
(Oryza sativa)
Liliopsida Os06g0318700 35
  • 49.14 (n)
  • 39.71 (a)
Species with no ortholog for MKRN2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for MKRN2 Gene

Gene Tree for MKRN2 (if available)
Gene Tree for MKRN2 (if available)

Paralogs for MKRN2 Gene

Paralogs for MKRN2 Gene

(3) SIMAP similar genes for MKRN2 Gene using alignment to 3 proteins: Pseudogenes for MKRN2 Gene

genes like me logo Genes that share paralogs with MKRN2: view

Variants for MKRN2 Gene

Sequence variations from dbSNP and Humsavar for MKRN2 Gene

SNP ID Clin Chr 03 pos Sequence Context AA Info Type
rs5746260 - 12,582,165(-) CATGC(C/T)GGCTT reference, missense
rs13106 -- 12,583,081(+) TATAC(A/G)TGCAC utr-variant-3-prime
rs15997 -- 12,582,571(+) TCTTA(C/T)CTTTG utr-variant-3-prime
rs713178 -- 12,574,485(-) TCCGT(A/G)AGGAC intron-variant
rs2305296 -- 12,568,954(+) CCACC(A/G)TCTGC intron-variant, reference, missense

Structural Variations from Database of Genomic Variants (DGV) for MKRN2 Gene

Variant ID Type Subtype PubMed ID
dgv810e201 CNV Deletion 23290073
dgv850e199 CNV Deletion 23128226
nsv7351 OTHER Inversion 18451855
esv2751977 CNV Gain 17911159
nsv876541 CNV Gain 21882294
nsv512796 CNV Insertion 21212237
dgv597n27 CNV Gain 19166990

Variation tolerance for MKRN2 Gene

Residual Variation Intolerance Score: 39.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.16; 23.37% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for MKRN2 Gene

Human Gene Mutation Database (HGMD)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MKRN2 Gene

Disorders for MKRN2 Gene

Relevant External Links for MKRN2

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for MKRN2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MKRN2 Gene

Publications for MKRN2 Gene

  1. Phylogenetic conservation of the makorin-2 gene, encoding a multiple zinc-finger protein, antisense to the raf1 proto-oncogene. (PMID: 11597136) Gray T.A. … Nicholls R.D. (Genomics 2001) 2 3 4 23 67
  2. SR protein kinases promote splicing of nonconsensus introns. (PMID: 26167880) Lipp J.J. … Guthrie C. (Nat. Struct. Mol. Biol. 2015) 3
  3. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  4. A human interactome in three quantitative dimensions organized by stoichiometries and abundances. (PMID: 26496610) Hein M.Y. … Mann M. (Cell 2015) 3
  5. A deep proteomics perspective on CRM1-mediated nuclear export and nucleocytoplasmic partitioning. (PMID: 26673895) KA+rlA+ K. … GAPrlich D. (Elife 2015) 3

Products for MKRN2 Gene

Sources for MKRN2 Gene