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Aliases for MKRN2 Gene

Aliases for MKRN2 Gene

  • Makorin Ring Finger Protein 2 2 3
  • RING Finger Protein 62 3 4
  • RNF62 3 4
  • Probable E3 Ubiquitin-Protein Ligase Makorin-2 3
  • Makorin RING Zinc-Finger Protein 2 3
  • EC 6.3.2.- 4
  • HSPC070 3

External Ids for MKRN2 Gene

Summaries for MKRN2 Gene

Entrez Gene Summary for MKRN2 Gene

  • This gene encodes a probable E3 ubiquitin ligase containing several zinc finger domains, that is a member of the makorin RING zinc-finger protein family. This gene overlaps the v-raf-1 murine leukemia viral oncogene homolog 1 (RAF1) gene in an antisense orientation and may have a co-regulatory function with RAF1. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2012]

GeneCards Summary for MKRN2 Gene

MKRN2 (Makorin Ring Finger Protein 2) is a Protein Coding gene. GO annotations related to this gene include ligase activity. An important paralog of this gene is MKRN3.

UniProtKB/Swiss-Prot for MKRN2 Gene

  • E3 ubiquitin ligase catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MKRN2 Gene

Genomics for MKRN2 Gene

Genomic Location for MKRN2 Gene

Start:
12,557,014 bp from pter
End:
12,583,713 bp from pter
Size:
26,700 bases
Orientation:
Plus strand

Genomic View for MKRN2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for MKRN2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MKRN2 Gene

Regulatory Elements for MKRN2 Gene

Proteins for MKRN2 Gene

  • Protein details for MKRN2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9H000-MKRN2_HUMAN
    Recommended name:
    Probable E3 ubiquitin-protein ligase makorin-2
    Protein Accession:
    Q9H000
    Secondary Accessions:
    • A6NIA2
    • B3KRC5
    • B4DPR4
    • Q8N391
    • Q96BD4
    • Q9BUY2
    • Q9NRY1

    Protein attributes for MKRN2 Gene

    Size:
    416 amino acids
    Molecular mass:
    46940 Da
    Quaternary structure:
    No Data Available
    Miscellaneous:
    • Partially overlaps and is antisense to the RAF1 proto-oncogene

    Alternative splice isoforms for MKRN2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for MKRN2 Gene

Proteomics data for MKRN2 Gene at MOPED

Post-translational modifications for MKRN2 Gene

  • Modification sites at PhosphoSitePlus
  • Ubiquitination at Lys42 and Lys334

Other Protein References for MKRN2 Gene

No data available for DME Specific Peptides for MKRN2 Gene

Domains for MKRN2 Gene

Gene Families for MKRN2 Gene

HGNC:
  • RNF :RING-type (C3HC4) zinc fingers

UniProtKB/Swiss-Prot:

MKRN2_HUMAN
Similarity:
  • Contains 4 C3H1-type zinc fingers.:
    • Q9H000
  • Contains 1 RING-type zinc finger.:
    • Q9H000
genes like me logo Genes that share domains with MKRN2: view

Function for MKRN2 Gene

Molecular function for MKRN2 Gene

UniProtKB/Swiss-Prot Function: E3 ubiquitin ligase catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins.

Enzyme Numbers (IUBMB) for MKRN2 Gene

Gene Ontology (GO) - Molecular Function for MKRN2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 17500595
GO:0008270 zinc ion binding IEA --
GO:0016874 ligase activity IEA --
GO:0044822 poly(A) RNA binding IDA 22681889
GO:0046872 metal ion binding --
genes like me logo Genes that share ontologies with MKRN2: view

Phenotypes for MKRN2 Gene

GenomeRNAi human phenotypes for MKRN2:
genes like me logo Genes that share phenotypes with MKRN2: view

miRNA for MKRN2 Gene

No data available for Animal Models , Transcription Factor Targeting and HOMER Transcription for MKRN2 Gene

Localization for MKRN2 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for MKRN2 Gene COMPARTMENTS Subcellular localization image for MKRN2 gene
Compartment Confidence
nucleus 3
cytosol 2

Gene Ontology (GO) - Cellular Components for MKRN2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular IDA 11597136
genes like me logo Genes that share ontologies with MKRN2: view

Pathways for MKRN2 Gene

SuperPathways for MKRN2 Gene

No Data Available

UniProtKB/Swiss-Prot Q9H000-MKRN2_HUMAN

  • Pathway: Protein modification; protein ubiquitination

Gene Ontology (GO) - Biological Process for MKRN2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008150 biological_process ND --
GO:0016567 protein ubiquitination IEA --
genes like me logo Genes that share ontologies with MKRN2: view

No data available for Pathways by source for MKRN2 Gene

Transcripts for MKRN2 Gene

Unigene Clusters for MKRN2 Gene

Makorin ring finger protein 2:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for MKRN2 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4a · 4b ^ 5a · 5b ^ 6 ^ 7a · 7b ^ 8 ^ 9
SP1: -
SP2:
SP3: - - - -
SP4: - -

Relevant External Links for MKRN2 Gene

GeneLoc Exon Structure for
MKRN2
ECgene alternative splicing isoforms for
MKRN2

Expression for MKRN2 Gene

mRNA expression in normal human tissues for MKRN2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for MKRN2 Gene

SOURCE GeneReport for Unigene cluster for MKRN2 Gene Hs.591666

mRNA Expression by UniProt/SwissProt for MKRN2 Gene

Q9H000-MKRN2_HUMAN
Tissue specificity: Widely expressed.
genes like me logo Genes that share expressions with MKRN2: view

Orthologs for MKRN2 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for MKRN2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia MKRN2 36
  • 99.2 (n)
  • 99.52 (a)
MKRN2 37
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia MKRN2 36
  • 85.06 (n)
  • 88.67 (a)
MKRN2 37
  • 85 (a)
OneToOne
dog
(Canis familiaris)
Mammalia MKRN2 36
  • 90.38 (n)
  • 93.51 (a)
MKRN2 37
  • 94 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Mkrn2 36
  • 85.1 (n)
  • 88.46 (a)
Mkrn2 16
Mkrn2 37
  • 88 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia MKRN2 37
  • 82 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia MKRN2 37
  • 57 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Mkrn2 36
  • 85.82 (n)
  • 88.7 (a)
chicken
(Gallus gallus)
Aves MKRN2 36
  • 73.41 (n)
  • 75.12 (a)
MKRN2 37
  • 74 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia MKRN2 37
  • 73 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.16155 36
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.2238 36
zebrafish
(Danio rerio)
Actinopterygii mkrn2 36
  • 62.18 (n)
  • 62.59 (a)
mkrn2 37
  • 59 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta CG12477 37
  • 29 (a)
ManyToMany
CG5334 37
  • 39 (a)
ManyToMany
CG5347 37
  • 40 (a)
ManyToMany
Mkrn1 37
  • 33 (a)
ManyToMany
CG5334 38
  • 42 (a)
CG12477 38
  • 45 (a)
Mkrn1 38
  • 33 (a)
CG5347 38
  • 37 (a)
worm
(Caenorhabditis elegans)
Secernentea Y55F3AM.6 37
  • 31 (a)
OneToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes LEE1 39
thale cress
(Arabidopsis thaliana)
eudicotyledons AT3G08505 36
  • 49.47 (n)
  • 40.71 (a)
rice
(Oryza sativa)
Liliopsida Os06g0318700 36
  • 49.14 (n)
  • 39.71 (a)
Species with no ortholog for MKRN2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for MKRN2 Gene

ENSEMBL:
Gene Tree for MKRN2 (if available)
TreeFam:
Gene Tree for MKRN2 (if available)

Paralogs for MKRN2 Gene

Paralogs for MKRN2 Gene

Selected SIMAP similar genes for MKRN2 Gene using alignment to 3 proteins:

Pseudogenes.org Pseudogenes for MKRN2 Gene

genes like me logo Genes that share paralogs with MKRN2: view

Variants for MKRN2 Gene

Sequence variations from dbSNP and Humsavar for MKRN2 Gene

SNP ID Clin Chr 03 pos Sequence Context AA Info Type MAF
rs13106 -- 12,583,081(+) TATAC(A/G)TGCAC utr-variant-3-prime
rs15997 -- 12,582,571(+) TCTTA(C/T)CTTTG utr-variant-3-prime
rs713178 -- 12,574,485(-) TCCGT(A/G)AGGAC intron-variant
rs1463664 -- 12,563,949(-) AAGAC(C/T)TCAAA intron-variant
rs1542848 -- 12,576,497(+) TGATT(A/G)TGATT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for MKRN2 Gene

Variant ID Type Subtype PubMed ID
dgv810e201 CNV Deletion 23290073
dgv850e199 CNV Deletion 23128226
nsv7351 OTHER Inversion 18451855
esv2751977 CNV Gain 17911159
nsv876541 CNV Gain 21882294
nsv512796 CNV Insertion 21212237
dgv597n27 CNV Gain 19166990

Relevant External Links for MKRN2 Gene

HapMap Linkage Disequilibrium report
MKRN2

Disorders for MKRN2 Gene

Relevant External Links for MKRN2

Genetic Association Database (GAD)
MKRN2
Human Genome Epidemiology (HuGE) Navigator
MKRN2
genes like me logo Genes that share disorders with MKRN2: view

No data available for UniProtKB/Swiss-Prot for MKRN2 Gene

Publications for MKRN2 Gene

  1. Phylogenetic conservation of the makorin-2 gene, encoding a multiple zinc-finger protein, antisense to the raf1 proto-oncogene. (PMID: 11597136) Gray T.A. … Nicholls R.D. (Genomics 2001) 2 3 4 23
  2. Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells. (PMID: 11042152) Zhang Q.-H. … Chen Z. (Genome Res. 2000) 3 4
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  5. Huntingtin interacting proteins are genetic modifiers of neurodegeneration. (PMID: 17500595) Kaltenbach L.S. … Hughes R.E. (PLoS Genet. 2007) 3

Products for MKRN2 Gene

Sources for MKRN2 Gene

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