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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

MKRN1 Gene

protein-coding   GIFtS: 56
GCID: GC07M140152

makorin ring finger protein 1
 Explore 8 diseases affiliated with
MKRN1 via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for MKRN1    

Aliases
for MKRN1 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
Makorin Ring Finger Protein 11 2
RNF611 2 3
RING Finger Protein 612 3
E3 Ubiquitin-Protein Ligase Makorin-12
EC 6.3.2.-3

External Ids:    HGNC: 71121   Entrez Gene: 236082   Ensembl: ENSG000001336067   OMIM: 6077545   UniProtKB: Q9UHC73   

Export aliases for MKRN1 gene to outside databases

Previous GC identifers: GC07M138423 GC07M139483 GC07M139560 GC07M139606 GC07M139799


Summaries
for MKRN1 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for MKRN1:
The Makorin ring finger protein-1 gene (MKRN1) is a highly transcribed, intron-containing source for a family of
intronless mammalian genes encoding a novel class of zinc finger proteins. Phylogenetic analyses indicate that the
MKRN1 gene is the ancestral founder of this gene family (Gray et al., 2000 (PubMed 10843807)).(supplied by OMIM, Mar
2008)

UniProtKB/Swiss-Prot: MKRN1_HUMAN, Q9UHC7
Function: E3 ubiquitin ligase catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins. These
substrates include FILIP1, p53/TP53, CDKN1A and TERT. Keeps cells alive by suppressing p53/TP53 under normal
conditions, but stimulates apoptosis by repressing CDKN1A under stress conditions. Acts as a negative regulator of
telomerase. Has negative and positive effects on RNA polymerase II-dependent transcription




Genomic Views
for MKRN1 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000007.13  NC_018918.1  NT_007914.15  NT_079596.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the MKRN1 gene promoter:
         AP-1   ATF-2   HNF-4alpha2   Meis-1b   GATA-1   PPAR-gamma1   c-Jun   PPAR-gamma2   Meis-1a   Meis-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 4): MKRN1 promoter sequence
   Search SABiosciences Chromatin IP Primers for MKRN1

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat MKRN1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 7q34   Ensembl cytogenetic band:  7q34   HGNC cytogenetic band: 7q34

MKRN1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
MKRN1 gene location

GeneLoc information about chromosome 7         GeneLoc Exon Structure

GeneLoc location for GC07M140152:  view genomic region     (about GC identifiers)

Start:
 140,152,840 bp from pter      End:
 140,179,369 bp from pter
Size:
 26,530 bases      Orientation:
 minus strand

1 alternative location:
Chr7-,CRA_TCAG 139,481,663-139,517,562     

Proteins
for MKRN1 gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: MKRN1_HUMAN, Q9UHC7 (See protein sequence)
Recommended Name: E3 ubiquitin-protein ligase makorin-1  
Size: 482 amino acids; 53349 Da
Subunit: Interacts with p53/TP53 and CDKN1A. Interacts with TERT, modulating telomere length homeostasis
Secondary accessions: A4D1T7 B3KXB4 Q256Y7 Q59G11 Q6GSF1 Q9H0G0 Q9UEZ7 Q9UHW2
Alternative splicing: 4 isoforms:  Q9UHC7-1   Q9UHC7-2   Q9UHC7-3   Q9UHC7-4   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for MKRN1: NX_Q9UHC7

Post-translational modifications:

  • Auto-ubiquitinated; which leads to proteasomal degradation1
  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q9UHC7

    • MKRN1 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins (2 alternative transcripts): 
    NP_001138597.1  NP_038474.2  

    ENSEMBL proteins: 
     ENSP00000255977   ENSP00000417640   ENSP00000417863   ENSP00000417346   ENSP00000419894  
     ENSP00000417907   ENSP00000416369   ENSP00000418864   ENSP00000418588   ENSP00000419843  
     ENSP00000419695   ENSP00000418620   ENSP00000419259   ENSP00000417797   ENSP00000439823  
    Reactome Protein details: Q9UHC7
    Human Recombinant Protein Products: 
    Browse Purified and Recombinant Proteins at EMD Millipore
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    OriGene Purified Protein: MKRN1
    OriGene Protein Over-expression Lysate: MKRN1
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    Novus Biologicals MKRN1 Proteins
    Novus Biologicals MKRN1 Lysate
    Browse Sino Biological Recombinant Proteins
    Browse ProSpec Recombinant Proteins
    Uscn Proteins for MKRN1

    Gene Ontology (GO): 1 cellular component term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005575cellular_component ND--


    MKRN1 for ontologies           About GeneDecksing



    MKRN1 Antibody Products: 
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    Novus Biologicals MKRN1 Antibodies
    Search for Antibodies for MKRN1 at Abcam  
    Uscn Antibodies for MKRN1
    Search ThermoFisher Antibodies for MKRN1

    Assay Products for MKRN1: 
    Browse Kits and Assays available from EMD Millipore
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    Uscn ELISAs and CLIAs for MKRN1

    Protein Domains /
    Families
    for MKRN1 gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    MKRN1 for domains           About GeneDecksing

    5 InterPro domains/families:
     IPR000571 Znf_CCCH
     IPR001841 Znf_RING
     IPR013083 Znf_RING/FYVE/PHD
     IPR017907 Znf_RING_CS
     IPR026290 Makorin-related

    Graphical View of Domain Structure for InterPro Entry Q9UHC7

    ProtoNet protein and cluster: Q9UHC7

    2 Blocks protein families:
    IPB000571 Zn-finger
    IPB001841 Zn-finger


    UniProtKB/Swiss-Prot: MKRN1_HUMAN, Q9UHC7
    Similarity: Contains 4 C3H1-type zinc fingers
    Similarity: Contains 1 RING-type zinc finger


    Function
    for MKRN1 gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: MKRN1_HUMAN, Q9UHC7
    Function: E3 ubiquitin ligase catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins. These
    substrates include FILIP1, p53/TP53, CDKN1A and TERT. Keeps cells alive by suppressing p53/TP53 under normal
    conditions, but stimulates apoptosis by repressing CDKN1A under stress conditions. Acts as a negative regulator of
    telomerase. Has negative and positive effects on RNA polymerase II-dependent transcription
    Induction: Frequently induced in esophageal squamous cell carcinoma (SCC) tissues

         Genatlas biochemistry entry for MKRN1:
    makorin,ring finger protein,1,mediating ubiquitin-conjugating enzyme (E2)-dependent ubiquitination

    Enzyme Number (IUBMB): EC 6.3.2.-1

    miRNA
    Products:            		miRTarBase miRNAs that target MKRN1:
    hsa-mir-373 (MIRT002511)

    OriGene 3'-UTR Clone (see all 2): MKRN1
    Browse MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat MKRN1
    8/42 QIAGEN miScript miRNA Assays for microRNAs that regulate MKRN1 (see all 42):
    hsa-miR-3130-5p hsa-miR-520e hsa-miR-302d hsa-miR-520f hsa-miR-106a hsa-miR-199a-3p hsa-miR-578 hsa-miR-29b-1*
    SwitchGear 3'UTR luciferase reporter plasmid: MKRN1 3' UTR sequence
    Inhib. RNA
    Products:            		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for MKRN1 (see all 7)
    OriGene shRNA RFP: MKRN1
    OriGene siRNA: MKRN1
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat MKRN1

    Gene Editing
    Products:    		DNA2.0 Custom Protein Engineering Service for MKRN1

    Clone
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    OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for MKRN1 (see all 5)
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    GenScript: all cDNA clones in your preferred vector (see all 2): MKRN1 (NM_013446)
    Browse Sino Biological Human cDNA Clones
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    Cell Line
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    Search LifeMap BioReagents cell lines for MKRN1

    In Situ Assay
    Products:       
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MKRN1

    Gene Ontology (GO): 5 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003674molecular_function ND--
    GO:0003676nucleic acid binding IEA--
    GO:0003682chromatin binding IEA--
    GO:0008270zinc ion binding IEA--
    GO:0016874ligase activity IEA--


    MKRN1 for ontologies           About GeneDecksing


    1 GenomeRNAi human phenotype for MKRN1:
     Wnt reporter downregulated 

    Animal Models:
         1 MGI mutant phenotype (inferred from 1 allele) (MGI details for Mkrn1):
     normal 

    MKRN1 for phenotypes           About GeneDecksing


    Pathways & Interactions
    for MKRN1 gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways  About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1Antigen processing: Ubiquitination & Proteasome degradation
    		Antigen processing: Ubiquitination & Proteasome degradation1.00
    		Polyubiquitination of substrate0.75
    		Class I MHC mediated antigen processing & presentation0.83
    2Immune System
    		Immune System1.00
    		Adaptive Immune System0.59

    Pathway sources
    See GeneCards unified pathways
    Show all pathways


    5        Reactome Pathways for MKRN1
        Antigen processing: Ubiquitination & Proteasome degradation
    Polyubiquitination of substrate
    Adaptive Immune System
    Class I MHC mediated antigen processing & presentation
    Immune System


    UniProtKB/Swiss-Prot: MKRN1_HUMAN, Q9UHC7
    Pathway: Protein modification; protein ubiquitination


    MKRN1 for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for MKRN1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 7)

    5/11 Interacting proteins for MKRN1 (Q9UHC72, 3 ENSP000002559774) via UniProtKB, MINT, STRING, and/or I2D (see all 11)

    InteractantInteraction Details
    GeneCardExternal ID(s)
    TP53P046372, 3, ENSP000002693054MINT-7298755 MINT-7298834 MINT-7298907 MINT-7298873 MINT-7298815 MINT-7298791 MINT-7298847 MINT-7298737 I2D: score=1 STRING: ENSP00000269305
    UBE2WQ96B022, 3, ENSP000003974534MINT-8276343 I2D: score=2 STRING: ENSP00000397453
    DUSP23Q9BVJ72, 3MINT-8254688 I2D: score=2 
    MAP1LC3BQ9GZQ82, 3MINT-8259682 I2D: score=2 
    UBE2D3P610772, 3MINT-8276119 I2D: score=2 
    About this table

    Gene Ontology (GO): 2 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0008150biological_process ND--
    GO:0016567protein ubiquitination IEA--


    MKRN1 for ontologies           About GeneDecksing



    Drugs & Compounds
    for MKRN1 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for MKRN1
    Search CenterWatch for drugs/clinical trials and news about MKRN1 

    Transcripts
    for MKRN1 gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for MKRN1 gene (2 alternative transcripts): 
    NM_001145125.1  NM_013446.3  

    Unigene Cluster for MKRN1:

    Makorin ring finger protein 1
    Hs.490347  [show with all ESTs]
    Unigene Representative Sequence: AK127030
    17 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000255977(uc003vvs.2 uc003vvt.2 uc011krd.1) ENST00000475010
    ENST00000495305 ENST00000474576 ENST00000463142 ENST00000468447 ENST00000480552
    ENST00000496169(uc003vvu.4) ENST00000443720(uc003vvv.4) ENST00000471104
    ENST00000467513 ENST00000494939 ENST00000498535 ENST00000473444 ENST00000475180
    ENST00000481705 ENST00000437223

    miRNA
    Products:             		 OriGene 3'-UTR Clone (see all 2): MKRN1
    Browse OriGene MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat MKRN1
    8/42 QIAGEN miScript miRNA Assays for microRNAs that regulate MKRN1 (see all 42):
    hsa-miR-3130-5p hsa-miR-520e hsa-miR-302d hsa-miR-520f hsa-miR-106a hsa-miR-199a-3p hsa-miR-578 hsa-miR-29b-1*
    SwitchGear 3'UTR luciferase reporter plasmid: MKRN1 3' UTR sequence
    Inhib. RNA
    Products:             		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for MKRN1 (see all 7)
    OriGene shRNA RFP: MKRN1
    OriGene siRNA: MKRN1
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat MKRN1
    Clone
    Products:             		 OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for MKRN1 (see all 5)
    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for MKRN1 (see all 2)
    OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector (see all 2): MKRN1 (NM_013446)
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    Primer
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      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat MKRN1
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat MKRN1

    Additional cDNA sequence: 

    AF117233.1 AF192784.1 AK024987.1 AK027137.1 AK127030.1 AK297361.1 AK315552.1 AL136812.1 
    AM236048.1 BC012398.2 BC025955.1 BC037400.1 BC051821.1 BC064838.1 BC127216.1 

    24/35 DOTS entries (see all 35):

    DT.453625  DT.100827849  DT.100827847  DT.100827858  DT.100827850  DT.92443839  DT.100030722  DT.100827857 
    DT.121067645  DT.92443863  DT.95093357  DT.100759782  DT.100030723  DT.100827856  DT.121067757  DT.100800096 
    DT.121067755  DT.95093362  DT.100827855  DT.100827860  DT.121067657  DT.121067671  DT.121067684  DT.121067767 

    24/538 AceView cDNA sequences (see all 538):

    BM802614 CK725045 AI554832 NM_013446 AA830058 AW196070 AI344542 AW511152 
    BM702443 CB120238 CB269182 AI611011 BC037400 AA653791 AI032903 AA704740 
    AI383326 AA919124 AI282160 AA010138 BM806585 BU196371 BM666746 BI522565 

    GeneLoc Exon Structure

    5/12 Alternative Splicing Database (ASD) splice patterns (SP) for MKRN1 (see all 12)    About this scheme

    ExUns: 1a · 1b ^ 2a · 2b · 2c ^ 3 ^ 4a · 4b ^ 5 ^ 6 ^ 7 ^ 8 ^ 9a · 9b · 9c · 9d ^ 10a · 10b · 10c ^ 11a · 11b · 11c ^ 12a · 12b · 12c ^ 13 ^
    SP1:              -     -     -     -     -     -     -     -     -                                                     -           -     -                     
    SP2:                                                  -     -     -                                                     -           -     -                     
    SP3:              -     -     -     -     -     -     -     -     -                                                     -           -     -                     
    SP4:              -     -     -     -     -     -     -     -     -                                                     -                                       
    SP5:                                                              -                                                                                             

    ExUns: 14a · 14b · 14c
    SP1:                  
    SP2:                  
    SP3:                  
    SP4:                  
    SP5:                  


    ECgene alternative splicing isoforms for MKRN1

    Expression
    for MKRN1 gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    MKRN1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: GTGTGAGTGT

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image

    MKRN1 expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
    Stem Cell Differentiation: 1 LifeMap Cell 
    NameCategory
    Definitive endoderm-like cells (A scalable, suspensi...)
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization

    See MKRN1 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for MKRN1

    SOURCE GeneReport for Unigene cluster: Hs.490347

    UniProtKB/Swiss-Prot: MKRN1_HUMAN, Q9UHC7
    Tissue specificity: Ubiquitous

        SABiosciences Expression via Pathway-Focused PCR Array including MKRN1: 
              Ubiquitin Ligases in human mouse rat

    Primer
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    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat MKRN1
    In Situ
    Assay Products:     
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MKRN1

    Orthologs
    for MKRN1 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of eukaryotes.

    Orthologs for MKRN1 gene from 8/24 species (see all 24)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    chicken
    (Gallus gallus)    		 Aves MKRN11 makorin ring finger protein 1 77.92(n)
    78.52(a)    		   395500  NM_204742.1  NP_990073.1 
    lizard
    (Anolis carolinensis)    		 Reptilia --
    --
    		 --
    		 77(a)
    54(a)
    		 1 ↔ 1
    possible ortholog
    		 5(15413045-15441296)
    4(120445977-120447953)
    African clawed frog
    (Xenopus laevis)    		 Amphibia Xl.168312 Xenopus laevis transcribed sequence with moderate similarity more 82.12(n)    CA791815.1 
    zebrafish
    (Danio rerio)    		 Actinopterygii mkrn12 makorin, ring finger protein, 1 76.39(n)   170782  AF277173.1 
    fruit fly
    (Drosophila melanogaster)    		 Insecta CG124773   -- 50(a)
    (best of 4)    		   75D7   --
    worm
    (Caenorhabditis elegans)    		 Secernentea Y55F3AM.61 Protein Y55F3AM.6 46.24(n)
    38.99(a)    		   176918  NM_001028339.2  NP_001023510.1 
    thale cress
    (Arabidopsis thaliana)    		 eudicotyledons AT3G085056
    		 E3 ubiquitin-protein ligase makorin
    		 33(a)
    		 1 → many
    		 3(2580077-2582129)
    rice
    (Oryza sativa)    		 Liliopsida --
    		 Zinc finger C-x8-C-x5-C-x3-H type domain containin...
    		 33(a)
    		 1 → many
    		 6(12351311-12357105)


    ENSEMBL Gene Tree for MKRN1 (if available)
    TreeFam Gene Tree for MKRN1 (if available) 

    Paralogs
    for MKRN1 gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for MKRN1 gene
    MKRN32  MKRN22  
    18/46 SIMAP similar genes for MKRN1 using alignment to 14 protein entries:     MKRN1_HUMAN (see all proteins) (see all similar genes):
    LGALS3    MKRN4P    LRRC36    C11orf80    CCPG1    MKRN9P
    C12orf23    SUN3    ATL2    SNRPF    QTRT1    THADA
    ZNHIT3    SENP7    CNOT2    KLHDC1    LAMA5    RHBG

    MKRN1 for paralogs           About GeneDecksing


    5/9 Pseudogenes.org Pseudogenes for MKRN1 (see all 9)
    PGOHUM00000239537 PGOHUM00000262240 PGOHUM00000243987 PGOHUM00000247551 PGOHUM00000240389


    Genomic Variants
    for MKRN1 gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/597 NCBI SNPs in MKRN1 are shown (see all 597)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 7 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs1129522071,2
    		C,--140152344(+) CCACCG/ACACCC 1 -- int11Minor allele frequency- A:0.50WA 2
    rs1472975461,2
    		--140152457(+) TTCTT-/ACTC  
                ACAAA     		1 -- int10--------
    rs734851451,2
    		C,--140152558(+) TCCCCC/TGTTAT 1 -- int11Minor allele frequency- T:0.50WA 2
    rs1511234761,2
    		--140152559(+) CCCCCA/GTTATC 1 -- int10--------
    rs737352521,2
    		C,--140152598(+) GTGCAT/CGGTAG 1 -- int12Minor allele frequency- C:0.06WA 120
    rs1411047341,2
    		--140152618(+) GCCAGA/TGCCTT 1 -- int10--------
    rs1931495171,2
    		--140152645(+) CCAGCA/GTTAGT 1 -- int10--------
    rs1844319981,2
    		--140152689(+) ACCCCA/GGCTAG 1 -- int10--------
    rs117608951,2
    		C,F,H,--140152722(+) ACACAC/AATTTC 1 -- int110Minor allele frequency- A:0.20NS EA WA NA CSA 655
    rs1469212201,2
    		--140152747(+) CTCCCA/GAATAT 1 -- int10--------

    HapMap Linkage Disequilibrium report for MKRN1 (140152840 - 140179369 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
          Database of Genomic Variants (DGV) variations for MKRN1: --

    SABiosciences Cancer Mutation PCR Assays
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    Disorders / Diseases
    for MKRN1 gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    MKRN1 for disorders           About GeneDecksing

    OMIM gene information: 607754    OMIM disorders: --

    8 diseases for MKRN1:    About MalaCards
    west nile virus    osteogenesis imperfecta    esophageal squamous cell carcinoma    squamous cell carcinoma
    polycystic kidney disease    kidney disease    esophagitis    carcinoma

    Human Genome Epidemiology (HuGE) Navigator: MKRN1 (1 document)

    Export disorders for MKRN1 gene to outside databases

    Publications
    for MKRN1 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for MKRN1 gene, integrated from 9 sources (see all 24):
    (articles sorted by number of sources associating them with MKRN1)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. The ancient source of a distinct gene family encoding proteins featuring RING and C(3)H zinc-finger motifs with abundant expression in developing brain and nervous system. (PubMed id 10843807)1, 2, 3, 9 Gray T.A.... Nicholls R.D. (2000)
    2. Identification of Makorin 1 as a novel SEREX antigen of esophageal squamous cell carcinoma. (PubMed id 19604354)1, 2, 9 Shimada H.... Hiwasa T. (2009)
    3. Differential regulation of p53 and p21 by MKRN1 E3 ligase controls cell cycle arrest and apoptosis. (PubMed id 19536131)1, 2, 9 Lee E.-W.... Song J. (2009)
    4. Makorin RING finger protein 1 (MKRN1) has negative and positive effects on RNA polymerase II-dependent transcription. (PubMed id 16785614)1, 2 Omwancha J.... Shemshedini L. (2006)
    5. Ubiquitin ligase MKRN1 modulates telomere length homeostasis through a proteolysis of hTERT. (PubMed id 15805468)1, 2 Kim J.H....Chung I.K. (2005)
    6. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    7. Towards a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs. (PubMed id 11230166)1, 2 Wiemann S.... Poustka A. (2001)
    8. Acceleration of gastric tumorigenesis through MKRN1-me diated posttranslational regulation of p14ARF. (PubMed id 23104211)1 Ko A....Song J. (2012)
    9. Methods for quantification of in vivo changes in prote in ubiquitination following proteasome and deubiquitinase inhibition. (PubMed id 22505724)1 Udeshi N.D....Carr S.A. (2012)
    10. A proteome-wide, quantitative survey of in vivo ubiqui tylation sites reveals widespread regulatory roles. (PubMed id 21890473)1 Wagner S.A....Choudhary C. (2011)

    External Searches for MKRN1 gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  
      Query String
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    Genome Databases showing MKRN1 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 23608 HGNC: 7112 AceView: MKRN1 Ensembl:ENSG00000133606 euGenes: HUgn23608
    ECgene: MKRN1 H-InvDB: MKRN1

    Other Databases showing MKRN1 gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing MKRN1 gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for MKRN1 Pharmacogenomics, SNPs, Pathways

    Intellectual Property
    for MKRN1 gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for MKRN1 gene:
    Search GeneIP for patents involving MKRN1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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