MKNK2 Gene
protein-coding GIFtS: 62
GCID: GC19M002037
|
|
MAP kinase interacting serine/threonine kinase 2(Previous name: G protein-coupled receptor kinase 7 )
(Previous symbol: GPRK7)
| |
Aliases
for MKNK2 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| MAP Kinase Interacting Serine/Threonine Kinase 21 2 | | MAPK Signal-Integrating Kinase 22 3 | | GPRK71 2 3 5 | | EC 2.7.11.13 8 | | MNK21 2 3 5 | | MAP Kinase-Interacting Serine/Threonine-Protein Kinase 22 | | G Protein-Coupled Receptor Kinase 71 2 | | Mnk23 | | MAP Kinase Signal-Integrating Kinase 22 3 | | EC 2.7.118 |
Export aliases for MKNK2 gene to outside databasesPrevious GC identifers: GC19M002100 GC19M001977 GC19M001988 GC19M001809 |
Summaries
for MKNK2 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for MKNK2:
This gene encodes a member of the calcium/calmodulin-dependent protein kinases (CAMK) Ser/Thr protein kinase family,which belongs to the protein kinase superfamily. This protein contains conserved DLG (asp-leu-gly) and ENIL(glu-asn-ile-leu) motifs, and an N-terminal polybasic region which binds importin A and the translation factorscaffold protein eukaryotic initiation factor 4G (eIF4G). This protein is one of the downstream kinases activated bymitogen-activated protein (MAP) kinases. It phosphorylates the eukaryotic initiation factor 4E (eIF4E), thus playingimportant roles in the initiation of mRNA translation, oncogenic transformation and malignant cell proliferation. Inaddition to eIF4E, this protein also interacts with von Hippel-Lindau tumor suppressor (VHL), ring-box 1 (Rbx1) andCullin2 (Cul2), which are all components of the CBC(VHL) ubiquitin ligase E3 complex. Multiple alternatively splicedtranscript variants have been found, but the full-length nature and biological activity of only two variants aredetermined. These two variants encode distinct isoforms which differ in activity and regulation, and in subcellularlocalization. (provided by RefSeq, Aug 2011)
UniProtKB/Swiss-Prot: MKNK2_HUMAN, Q9HBH9Function: Serine/threonine-protein kinase that phosphorylates SFPQ/PSF, HNRNPA1 and EIF4E. May play a role in theresponse to environmental stress and cytokines. Appears to regulate translation by phosphorylating EIF4E, thusincreasing the affinity of this protein for the 7-methylguanosine-containing mRNA cap. Required for mediatingPP2A-inhibition-induced EIF4E phosphorylation. Triggers EIF4E shuttling from cytoplasm to nucleus. Isoform 1 displaysa high basal kinase activity, but isoform 2 exhibits a very low kinase activity. Acts as a mediator of the suppressiveeffects of IFNgamma on hematopoiesis. Negative regulator for signals that control generation of arsenic trioxideAs(2)O(3)-dependent apoptosis and anti-leukemic responses. Involved in anti-apoptotic signaling in response to serumwithdrawal
Gene Wiki entry for MKNK2
|
Genomic Views
for MKNK2 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000019.9 NC_018930.1 NT_011255.14
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the MKNK2 gene promoter:
SREBP-1c NRSF form 1 HTF HSF1 (long) NRSF form 2 E2F E2F-1 HSF2 HSF1short Pax-4a
Other transcription factors
Search SABiosciences Chromatin IP Primers for MKNK2
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat MKNK2 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 19p13.3 Ensembl cytogenetic band: 19p13.3 HGNC cytogenetic band: 19p13.3MKNK2 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 19 GeneLoc Exon Structure GeneLoc location for GC19M002037: view genomic region
(about GC identifiers)
Start:
|
2,037,470 bp from pter |
End:
|
2,051,243 bp from pter |
Size:
|
13,774 bases |
Orientation:
|
minus strand |
|
Proteins
for MKNK2 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: MKNK2_HUMAN, Q9HBH9 (See
protein sequence)Recommended Name: MAP kinase-interacting serine/threonine-protein kinase 2 Size: 465 amino acids; 51875 Da
Cofactor: Magnesium
Cofactor: Binds 1 zinc ion per subunit
Subunit: Monomer. Interacts with the C-terminal regions of EIF4G1 and EIF4G2; this interaction is promoted when MAPKpathways are repressed but repressed upon ERK proteins activation. Also binds to dephosphorylated MAPK3/ERK1 andMAPK1/ERK2. Isoform 1 interaction with phosphorylated MAPK3/ERK1 and MAPK1/ERK2 protects it from dephosphorylation andinactivation. Isoform 2 interacts with ESR2 and EIF4E in the nucleus
Subcellular location: Isoform 2: Nucleus, PML body
Subcellular location: Isoform 1: Cytoplasm
3 PDB 3D structures from  and Proteopedia  for MKNK2:2AC3 (3D)
2AC5 (3D)
2HW7 (3D)
Secondary accessions: Q6GPI3 Q9HBH8 Q9UHR0 Q9Y2N6Alternative splicing: 5 isoforms: Q9HBH9-1 Q9HBH9-2 Q9HBH9-3 Q9HBH9-4 Q9HBH9-5 Explore the universe of human proteins at neXtProt for MKNK2: NX_Q9HBH9
Post-translational modifications:
Dual phosphorylation of Thr-244 and Thr-249 activates the kinase. Phosphorylation of Thr-379 activates the kinase.Phosphorylated upon arsenic trioxide As(2)O(3) treatment. Phosphorylated by MAPK1/ERK2, MAPK11 and MAPK14.Dephosphorylated by PP2A1
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q9HBH9
4/21 DME Specific Peptides for MKNK2 (Q9HBH9) (see all 21)
MKNK2 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins (2 alternative transcripts):
NP_060042.2 NP_951009.1
ENSEMBL proteins: ENSP00000465645 ENSP00000467811 ENSP00000309485 ENSP00000466594 ENSP00000465425 ENSP00000464828 ENSP00000465079 ENSP00000466064 ENSP00000466147 ENSP00000250896 ENSP00000438904
Human Recombinant Protein Products:
Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view): About this table
MKNK2 for ontologies About GeneDecksing
MKNK2 Antibody Products:
Assay Products for MKNK2: |
Protein
Domains /
Families
for MKNK2 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
MKNK2 for domains About GeneDecksing
5 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry Q9HBH9ProtoNet protein and cluster: Q9HBH9 UniProtKB/Swiss-Prot: MKNK2_HUMAN, Q9HBH9Similarity: Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase familySimilarity: Contains 1 protein kinase domain |
Function
for MKNK2 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: MKNK2_HUMAN, Q9HBH9Function: Serine/threonine-protein kinase that phosphorylates SFPQ/PSF, HNRNPA1 and EIF4E. May play a role in theresponse to environmental stress and cytokines. Appears to regulate translation by phosphorylating EIF4E, thusincreasing the affinity of this protein for the 7-methylguanosine-containing mRNA cap. Required for mediatingPP2A-inhibition-induced EIF4E phosphorylation. Triggers EIF4E shuttling from cytoplasm to nucleus. Isoform 1 displaysa high basal kinase activity, but isoform 2 exhibits a very low kinase activity. Acts as a mediator of the suppressiveeffects of IFNgamma on hematopoiesis. Negative regulator for signals that control generation of arsenic trioxideAs(2)O(3)-dependent apoptosis and anti-leukemic responses. Involved in anti-apoptotic signaling in response to serumwithdrawalCatalytic activity: ATP + a protein = ADP + a phosphoproteinEnzyme regulation: Inhibited by CGP57380 and staurosporine. Activated by phosphorylation in a negative-feedbackregulatory manner in response to chemotherapy (e.g. cytarabine) and thus impairs the generation of antileukemicresponsesEnzyme Numbers (IUBMB): EC 2.7.11.11 2 EC 2.7.112
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for MKNK2 (see all 4)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for MKNK2 (see all 2)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector (see all 2): MKNK2 (NM_017572) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for MKNK2 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MKNK2 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MKNK2 |
Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view): About this table
MKNK2 for ontologies About GeneDecksing
4 GenomeRNAi human phenotypes for MKNK2:
Animal Models:
Mouse knock-out Mknk2tm1Fuku for MKNK2
1 MGI mutant phenotype (inferred from 1 allele ) (MGI details for Mknk2):
MKNK2 for phenotypes About GeneDecksing
|
Pathways & Interactions
for MKNK2 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Unified GeneCards pathways About this table
See pathways by source
| Super-pathway | contained gene-specific pathways |
|---|
| 1 | Development_CNTF receptor signaling | | | 2 | Rho Family GTPases | | | 3 | Akt Signaling | | | 4 | TGF-Beta Pathway | | | 5 | MAPK signaling pathway | |
Pathway sources
See GeneCards unified pathways
Show all pathways
1 EMD Millipore Pathway for MKNK2
4 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for MKNK2
1  GeneGo (Thomson Reuters) Pathway for MKNK2
2 
Kegg Pathways (Kegg details for MKNK2):
MKNK2 for pathways About GeneDecksing
Interactions:
SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for MKNK2
STRING Interaction
Network Preview (showing 5 interactants - click image to see 15)
5/23 Interacting proteins for MKNK2 (Q9HBH93 ENSP000002508964) via UniProtKB, MINT, STRING, and/or I2D (see all 23)About this table
Gene Ontology (GO): 5/7 biological process terms (GO ID links to tree view) (see all 7): About this table
MKNK2 for ontologies About GeneDecksing
|
Drugs & Compounds
for MKNK2 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Compounds for MKNK2 available from Tocris Bioscience About this table
| Compound | Action |
CAS
# |
|---|
| CGP 57380 | Selective inhibitor of Mnk1 | [522629-08-9] |
3 HMDB Compounds for MKNK2 About this table
Search CenterWatch for drugs/clinical trials and news about MKNK2
|
Transcripts
for MKNK2 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for MKNK2 gene (2 alternative transcripts): NM_017572.3 NM_199054.2 Unigene Cluster for MKNK2: MAP kinase interacting serine/threonine kinase 2 Hs.515032 [show with all ESTs]Unigene Representative Sequence: NM_19905415 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000591142 ENST00000591601 ENST00000309340(uc002luq.1 uc002lur.2)
ENST00000587416 ENST00000589441 ENST00000586828 ENST00000591588 ENST00000588014
ENST00000585667 ENST00000586620 ENST00000588346 ENST00000589534 ENST00000589509
ENST00000250896(uc010xgu.1 uc010xgv.1 uc002lus.2 uc002lut.1)
ENST00000541165
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for MKNK2 (see all 4)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for MKNK2 (see all 2)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector (see all 2): MKNK2 (NM_017572) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for MKNK2 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MKNK2 |
Additional cDNA sequence: AF125532.1 AF237775.1 AF237776.1 AK001730.1 AK023442.1 AK024347.1 AK092536.1 AK293742.1 AK303393.1 AL137565.1 AL137615.1 BC018345.1 BC021235.2 BC073140.1 Z25424.1 20 DOTS entries: DT.75146534 DT.92442931 DT.100811104 DT.99951936 DT.95075088 DT.100811101 DT.121414405 DT.92036671 DT.92442932 DT.100811099 DT.100038245 DT.121414866 DT.100811102 DT.100811098 DT.95173654 DT.99973523 DT.121414563 DT.92013386 DT.75116823 DT.99997695 24/529 AceView cDNA sequences (see all 529): AW939139 CR599500 BM696657 BG169666 BM904815 AI638815 BM808866 BQ073318 BU728615 BC009267 BM773111 BG034035 BG176606 BU735170 AA083866 CR594022 BM458139 F29206 BQ685038 BQ940812 AI167533 NM_012458 BQ230940 BQ639743
GeneLoc Exon Structure
5/10 Alternative Splicing Database (ASD) splice patterns (SP) for MKNK2 (see all 10) About this scheme
| ExUns: | 1 | ^ | 2a | · | 2b | · | 2c | ^ | 3 | ^ | 4 | ^ | 5 | ^ | 6a | · | 6b | ^ | 7a | · | 7b | ^ | 8 | ^ | 9 | ^ | 10a | · | 10b | · | 10c | ^ | 11a | · | 11b | · | 11c | ^ | 12a | · | 12b | ^ | 13a | · | 13b | ^ | 14a | · | 14b |
|---|
|
| SP1: | | | | | | | - | | | | | | | | | | | | | | | | | | | | - | | - | | | | | | - | | - | | | | - | | | | | | | | | | |
| SP2: | | | | | | | - | | | | | | | | | | | | | | | | | | | | - | | - | | | | | | - | | - | | | | - | | - | | - | | | | | | |
| SP3: | | | | | | | | | | | | | | | | | | | | | | | | | | | - | | - | | | | | | | | | | | | | | | | | | | | | | |
| SP4: | | | | | | | | | | | | | | | | | | | | | | | | | | | - | | - | | | | | | - | | - | | | | | | | | | | | | | | |
| SP5: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
ECgene alternative splicing isoforms for MKNK2
|
Expression
for MKNK2 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| MKNK2 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: TGTTAATGTT
About this image
See MKNK2 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for MKNK2
SOURCE GeneReport for Unigene cluster: Hs.515032
UniProtKB/Swiss-Prot: MKNK2_HUMAN, Q9HBH9Tissue specificity: Ubiquitously expressed in all tissues examined. Isoform 2 is expressed at higher levels in theovary than is isoform 1
SABiosciences Custom PCR Arrays for MKNK2
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for MKNK2
Browse OriGene validated miRNA SYBR primer pairs
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Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MKNK2 |
Orthologs
for MKNK2 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of animals.
Orthologs for MKNK2 gene from 7/21 species (see all 21) About this table
| Organism |
Taxonomic
classification |
Gene |
Description |
Human
Similarity |
Orthology
Type |
Details |
mouse
(Mus musculus) |
Mammalia |
Mknk21 , 5 |
MAP kinase-interacting serine/threonine kinase 21, 5 |
88.67(n)1
95.39(a)1 |
|
10 (39.72 cM)5
173471 NM_021462.31 NP_067437.11
806653325 |
chicken
(Gallus gallus) |
Aves |
MKNK21 |
MAP kinase interacting serine/threonine kinase 2 |
84.49(n)
85.6(a) |
|
429269 XM_426826.3 XP_426826.3 |
lizard
(Anolis carolinensis) |
Reptilia |
MKNK26 |
-- |
81(a) |
1 ↔ 1 |
AAWZ02036575(16-11983) |
African clawed frog
(Xenopus laevis) |
Amphibia |
MGC684472 |
hypothetical protein MGC68447 |
76.17(n) |
|
BC063717.1 |
zebrafish
(Danio rerio) |
Actinopterygii |
BC044375.12 |
-- |
77.77(n) |
|
373121 BC044375.1 |
fruit fly
(Drosophila melanogaster) |
Insecta |
Lk61 , 3 |
microtubule-based process protein kinase3
CG17342-PA1 |
61(a)3
58.49(n)1
56.33(a)1 |
|
3 86F63
446721 NM_143729.21 NP_651986.21 |
worm
(Caenorhabditis elegans) |
Secernentea |
mnk-16 |
MAP kinase iNtegrating Kinase (MNK) homolog family... |
24(a) |
1 → many |
II(10544150-10554984) |
ENSEMBL Gene Tree for MKNK2 (if available)
TreeFam Gene Tree for MKNK2 (if available) |
Paralogs
for MKNK2 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for MKNK2 gene
- MAPKAPK52 MAPKAPK32 MAPKAPK22 MKNK12
18/35 SIMAP similar genes for MKNK2 using alignment to 8 protein entries: MKNK2_HUMAN (see all proteins)
(see all similar genes):DKFZp586A1021 MKNK1 DKFZp686E14208 MAPKAPK5 RPS6KA1 CAMK2A
CASK STK17A CAMK2B CAMK2D CAMK2G RPS6KA6
PHKG1 MAPKAPK3 PRKAA1 PSKH2 RPS6KA5 RPS6KA2
MKNK2 for paralogs About GeneDecksing
1 Pseudogenes.org Pseudogene for MKNK2
PGOHUM00000238408
|
Genomic Variants
for MKNK2 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 19 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for MKNK2 (2037470 - 2051243 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 3 variations for MKNK2
3 CNVs: 30064 30062 30065 | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing MKNK2 |
|
Disorders
/ Diseases
for MKNK2 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
MKNK2 for disorders About GeneDecksing
OMIM gene information: 605069
OMIM disorders: --
5  diseases for MKNK2: About MalaCardsmenkes disease hematopoiesis immunodeficiency malaria
alcoholism
Human Genome Epidemiology (HuGE) Navigator: MKNK2 (1 document)
Export disorders for MKNK2 gene to outside databases
|
Publications
for MKNK2 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for MKNK2 gene, integrated from 9 sources (see all 34):
(articles sorted by number of sources associating them with MKNK2) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Identification of the human Mnk2 gene (MKNK2) through protein interaction with estrogen receptor beta. (PubMed id 11013076)1, 2, 3, 9 Slentz-Kesler K....Weiner M.P. (2000)
- The mitogen-activated protein kinase signal-integrating kinase Mnk2 is a eukaryotic initiation factor 4E kinase with high levels of basal activity in mammalian cells. (PubMed id 11154262)1, 2, 9 Scheper G.C.... Proud C.G. (2001)
- Regulation of arsenic trioxide-induced cellular responses by Mnk1 and Mnk2. (PubMed id 18299328)1, 2, 9 Dolniak B....Platanias L.C. (2008)
- Essential role for Mnk kinases in type II interferon (IFNgamma) signaling and its suppressive effects on normal hematopoiesis. (PubMed id 21149447)1, 2 Joshi S....Platanias L.C. (2011)
- The Mnks: MAP kinase-interacting kinases (MAP kinase signal-integrating kinases). (PubMed id 18508592)1, 2 Buxade M....Proud C.G. (2008)
- Crystal structures of the Mnk2 kinase domain reveal an inhibitory conformation and a zinc binding site. (PubMed id 16216586)1, 2 Jauch R....Wahl M.C. (2005)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- The DNA sequence and biology of human chromosome 19. (PubMed id 15057824)1, 2 Grimwood J.... Lucas S.M. (2004)
- The N and C termini of the splice variants of the human mitogen-activated protein kinase-interacting kinase Mnk2 determine activity and localization. (PubMed id 12897141)1, 2 Scheper G.C....Proud C.G. (2003)
- Negative regulation of protein translation by mitogen-activated protein kinase-interacting kinases 1 and 2. (PubMed id 11463832)1, 2 Knauf U.... Gram H. (2001)
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External Searches for MKNK2 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
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Genome Databases showing MKNK2 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
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Other Databases showing MKNK2 gene
(According to HUGE)
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Specialized Databases showing MKNK2 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
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| Patent Information for MKNK2 gene:
Search GeneIP for patents involving MKNK2
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
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Products
for MKNK2 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
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| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for MKNK2 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for MKNK2 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for MKNK2 | | | OriGene Protein Over-expression Lysate for MKNK2 | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for MKNK2 | | OriGene 3'-UTR Clone for MKNK2 | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for MKNK2 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for MKNK2 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | OriGene Purified Protein for MKNK2 | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for MKNK2 | | OriGene Custom Protein Services for MKNK2 | | | OriGene Custom Immunoassay Development | | |
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat MKNK2 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing MKNK2 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat MKNK2 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat MKNK2 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat MKNK2 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat MKNK2 |
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| | | | Tocris compounds for MKNK2 |
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 | | | MKNK2 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MKNK2 |
|  |  |  | | | | ThermoFisher Antibodies for MKNK2 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MKNK2 |
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