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Aliases for MKNK2 Gene

Aliases for MKNK2 Gene

  • MAP Kinase Interacting Serine/Threonine Kinase 2 2 3
  • GPRK7 3 4 6
  • MNK2 3 4 6
  • MAP Kinase Signal-Integrating Kinase 2 3 4
  • G Protein-Coupled Receptor Kinase 7 2 3
  • MAPK Signal-Integrating Kinase 2 3 4
  • EC 2.7.11.1 4 64
  • MAP Kinase-Interacting Serine/Threonine-Protein Kinase 2 3
  • Putative Map Kinase Interacting Kinase 2
  • EC 2.7.11 64

External Ids for MKNK2 Gene

Previous Symbols for MKNK2 Gene

  • GPRK7

Summaries for MKNK2 Gene

Entrez Gene Summary for MKNK2 Gene

  • This gene encodes a member of the calcium/calmodulin-dependent protein kinases (CAMK) Ser/Thr protein kinase family, which belongs to the protein kinase superfamily. This protein contains conserved DLG (asp-leu-gly) and ENIL (glu-asn-ile-leu) motifs, and an N-terminal polybasic region which binds importin A and the translation factor scaffold protein eukaryotic initiation factor 4G (eIF4G). This protein is one of the downstream kinases activated by mitogen-activated protein (MAP) kinases. It phosphorylates the eukaryotic initiation factor 4E (eIF4E), thus playing important roles in the initiation of mRNA translation, oncogenic transformation and malignant cell proliferation. In addition to eIF4E, this protein also interacts with von Hippel-Lindau tumor suppressor (VHL), ring-box 1 (Rbx1) and Cullin2 (Cul2), which are all components of the CBC(VHL) ubiquitin ligase E3 complex. Multiple alternatively spliced transcript variants have been found, but the full-length nature and biological activity of only two variants are determined. These two variants encode distinct isoforms which differ in activity and regulation, and in subcellular localization. [provided by RefSeq, Aug 2011]

GeneCards Summary for MKNK2 Gene

MKNK2 (MAP Kinase Interacting Serine/Threonine Kinase 2) is a Protein Coding gene. Among its related pathways are MAPK signaling pathway and Akt Signaling. GO annotations related to this gene include protein serine/threonine kinase activity. An important paralog of this gene is RPS6KA6.

UniProtKB/Swiss-Prot for MKNK2 Gene

  • Serine/threonine-protein kinase that phosphorylates SFPQ/PSF, HNRNPA1 and EIF4E. May play a role in the response to environmental stress and cytokines. Appears to regulate translation by phosphorylating EIF4E, thus increasing the affinity of this protein for the 7-methylguanosine-containing mRNA cap. Required for mediating PP2A-inhibition-induced EIF4E phosphorylation. Triggers EIF4E shuttling from cytoplasm to nucleus. Isoform 1 displays a high basal kinase activity, but isoform 2 exhibits a very low kinase activity. Acts as a mediator of the suppressive effects of IFNgamma on hematopoiesis. Negative regulator for signals that control generation of arsenic trioxide As(2)O(3)-dependent apoptosis and anti-leukemic responses. Involved in anti-apoptotic signaling in response to serum withdrawal.

Gene Wiki entry for MKNK2 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MKNK2 Gene

Genomics for MKNK2 Gene

Genomic Location for MKNK2 Gene

Start:
2,037,465 bp from pter
End:
2,051,244 bp from pter
Size:
13,780 bases
Orientation:
Minus strand

Genomic View for MKNK2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for MKNK2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MKNK2 Gene

Regulatory Elements for MKNK2 Gene

Proteins for MKNK2 Gene

  • Protein details for MKNK2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9HBH9-MKNK2_HUMAN
    Recommended name:
    MAP kinase-interacting serine/threonine-protein kinase 2
    Protein Accession:
    Q9HBH9
    Secondary Accessions:
    • Q6GPI3
    • Q9HBH8
    • Q9UHR0
    • Q9Y2N6

    Protein attributes for MKNK2 Gene

    Size:
    465 amino acids
    Molecular mass:
    51875 Da
    Cofactor:
    Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
    Cofactor:
    Name=Zn(2+); Xref=ChEBI:CHEBI:29105; Note=Binds 1 zinc ion per subunit.;
    Quaternary structure:
    • Monomer. Interacts with the C-terminal regions of EIF4G1 and EIF4G2; this interaction is promoted when MAPK pathways are repressed but repressed upon ERK proteins activation. Also binds to dephosphorylated MAPK3/ERK1 and MAPK1/ERK2. Isoform 1 interaction with phosphorylated MAPK3/ERK1 and MAPK1/ERK2 protects it from dephosphorylation and inactivation. Isoform 2 interacts with ESR2 and EIF4E in the nucleus.

    Three dimensional structures from OCA and Proteopedia for MKNK2 Gene

    Alternative splice isoforms for MKNK2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for MKNK2 Gene

Proteomics data for MKNK2 Gene at MOPED

Post-translational modifications for MKNK2 Gene

  • Dual phosphorylation of Thr-244 and Thr-249 activates the kinase. Phosphorylation of Thr-379 activates the kinase. Phosphorylated upon arsenic trioxide As(2)O(3) treatment. Phosphorylated by MAPK1/ERK2, MAPK11 and MAPK14. Dephosphorylated by PP2A.
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Domains for MKNK2 Gene

Gene Families for MKNK2 Gene

UniProtKB/Swiss-Prot:

MKNK2_HUMAN
Domain:
  • Contains 1 protein kinase domain.:
    • Q9HBH9
Family:
  • Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family.:
    • Q9HBH9
genes like me logo Genes that share domains with MKNK2: view

Function for MKNK2 Gene

Molecular function for MKNK2 Gene

UniProtKB/Swiss-Prot CatalyticActivity: ATP + a protein = ADP + a phosphoprotein.
UniProtKB/Swiss-Prot EnzymeRegulation: Inhibited by CGP57380 and staurosporine. Activated by phosphorylation in a negative-feedback regulatory manner in response to chemotherapy (e.g. cytarabine) and thus impairs the generation of antileukemic responses.
UniProtKB/Swiss-Prot Function: Serine/threonine-protein kinase that phosphorylates SFPQ/PSF, HNRNPA1 and EIF4E. May play a role in the response to environmental stress and cytokines. Appears to regulate translation by phosphorylating EIF4E, thus increasing the affinity of this protein for the 7-methylguanosine-containing mRNA cap. Required for mediating PP2A-inhibition-induced EIF4E phosphorylation. Triggers EIF4E shuttling from cytoplasm to nucleus. Isoform 1 displays a high basal kinase activity, but isoform 2 exhibits a very low kinase activity. Acts as a mediator of the suppressive effects of IFNgamma on hematopoiesis. Negative regulator for signals that control generation of arsenic trioxide As(2)O(3)-dependent apoptosis and anti-leukemic responses. Involved in anti-apoptotic signaling in response to serum withdrawal.

Enzyme Numbers (IUBMB) for MKNK2 Gene

Gene Ontology (GO) - Molecular Function for MKNK2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004672 protein kinase activity --
GO:0004674 protein serine/threonine kinase activity IDA 11463832
GO:0004683 calmodulin-dependent protein kinase activity IBA --
GO:0004713 protein tyrosine kinase activity --
GO:0005515 protein binding IPI 20936779
genes like me logo Genes that share ontologies with MKNK2: view
genes like me logo Genes that share phenotypes with MKNK2: view

Animal Models for MKNK2 Gene

MGI Knock Outs for MKNK2:

No data available for Transcription Factor Targeting and HOMER Transcription for MKNK2 Gene

Localization for MKNK2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for MKNK2 Gene

Isoform 2: Nucleus, PML body.
Isoform 1: Cytoplasm.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for MKNK2 Gene COMPARTMENTS Subcellular localization image for MKNK2 gene
Compartment Confidence
nucleus 5
cytosol 3

Gene Ontology (GO) - Cellular Components for MKNK2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA --
GO:0005654 nucleoplasm IDA --
GO:0005730 nucleolus IDA --
GO:0005737 cytoplasm IBA --
GO:0016020 membrane --
genes like me logo Genes that share ontologies with MKNK2: view

Pathways for MKNK2 Gene

genes like me logo Genes that share pathways with MKNK2: view

Pathways by source for MKNK2 Gene

1 GeneGo (Thomson Reuters Life Sciences Research) pathway for MKNK2 Gene

Gene Ontology (GO) - Biological Process for MKNK2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006417 regulation of translation IEA --
GO:0006468 protein phosphorylation IDA 11463832
GO:0007166 cell surface receptor signaling pathway TAS 8415712
GO:0009103 lipopolysaccharide biosynthetic process --
GO:0018105 peptidyl-serine phosphorylation IBA --
genes like me logo Genes that share ontologies with MKNK2: view

Compounds for MKNK2 Gene

(3) Tocris Compounds for MKNK2 Gene

Compound Action Cas Number
HI TOPK 032 Selective T-LAK-cell-originated protein kinase (TOPK) inhibitor [487020-03-1]
NQDI 1 Inhibitor of apoptosis signal-regulating kinase 1 (ASK1) [175026-96-7]
PF 3644022 Potent MK2 inhibitor [1276121-88-0]

(3) HMDB Compounds for MKNK2 Gene

Compound Synonyms Cas Number PubMed IDs
Adenosine triphosphate
  • 5'-(tetrahydrogen triphosphate) Adenosine
56-65-5
ADP
  • adenosindiphosphorsaeure
58-64-0
Magnesium
  • Magnesium
7439-95-4
genes like me logo Genes that share compounds with MKNK2: view

Transcripts for MKNK2 Gene

Unigene Clusters for MKNK2 Gene

MAP kinase interacting serine/threonine kinase 2:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for MKNK2 Gene

ExUns: 1 ^ 2a · 2b · 2c ^ 3 ^ 4 ^ 5 ^ 6a · 6b ^ 7a · 7b ^ 8 ^ 9 ^ 10a · 10b · 10c ^ 11a · 11b · 11c ^ 12a · 12b ^ 13a · 13b ^ 14a · 14b
SP1: - - - - - -
SP2: - - - - - - - -
SP3: - -
SP4: - - - -
SP5:
SP6: - - - - -
SP7: - - -
SP8: - -
SP9:
SP10:

Relevant External Links for MKNK2 Gene

GeneLoc Exon Structure for
MKNK2
ECgene alternative splicing isoforms for
MKNK2

Expression for MKNK2 Gene

mRNA expression in normal human tissues for MKNK2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for MKNK2 Gene

This gene is overexpressed in Muscle - Skeletal (13.1).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for MKNK2 Gene

SOURCE GeneReport for Unigene cluster for MKNK2 Gene Hs.515032

mRNA Expression by UniProt/SwissProt for MKNK2 Gene

Q9HBH9-MKNK2_HUMAN
Tissue specificity: Ubiquitously expressed in all tissues examined. Isoform 2 is expressed at higher levels in the ovary than is isoform 1.
genes like me logo Genes that share expressions with MKNK2: view

Orthologs for MKNK2 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for MKNK2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia MKNK2 36
  • 95.34 (n)
  • 95.57 (a)
MKNK2 37
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia MKNK2 36
  • 90.88 (n)
  • 94.61 (a)
MKNK2 37
  • 95 (a)
OneToOne
dog
(Canis familiaris)
Mammalia MKNK2 36
  • 89.31 (n)
  • 92.02 (a)
MKNK2 37
  • 91 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Mknk2 36
  • 88.67 (n)
  • 95.39 (a)
Mknk2 16
Mknk2 37
  • 95 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia MKNK2 37
  • 80 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia MKNK2 37
  • 84 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Mknk2 36
  • 88.11 (n)
  • 94.31 (a)
chicken
(Gallus gallus)
Aves MKNK2 36
  • 83.17 (n)
  • 84.17 (a)
MKNK2 37
  • 82 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia MKNK2 37
  • 82 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia MGC68447 36
tropical clawed frog
(Silurana tropicalis)
Amphibia mknk2 36
  • 71.37 (n)
  • 78.52 (a)
zebrafish
(Danio rerio)
Actinopterygii -- 36
mknk2a 37
  • 74 (a)
OneToMany
mknk2b 36
  • 72.5 (n)
  • 79.21 (a)
mknk2b 37
  • 75 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta Lk6 37
  • 21 (a)
OneToMany
Lk6 38
  • 61 (a)
worm
(Caenorhabditis elegans)
Secernentea mnk-1 36
  • 53.89 (n)
  • 50 (a)
mnk-1 37
  • 28 (a)
OneToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes RCK1 37
  • 22 (a)
ManyToMany
RCK2 37
  • 19 (a)
ManyToMany
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.15288 36
sea squirt
(Ciona savignyi)
Ascidiacea CSA.11342 37
  • 58 (a)
OneToMany
Species with no ortholog for MKNK2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for MKNK2 Gene

ENSEMBL:
Gene Tree for MKNK2 (if available)
TreeFam:
Gene Tree for MKNK2 (if available)

Paralogs for MKNK2 Gene

Pseudogenes.org Pseudogenes for MKNK2 Gene

genes like me logo Genes that share paralogs with MKNK2: view

Variants for MKNK2 Gene

Sequence variations from dbSNP and Humsavar for MKNK2 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type MAF
rs10294 -- 2,037,607(+) TTTTC(C/T)CCCAC utr-variant-3-prime
rs880183 -- 2,049,315(+) GGCAA(A/G)GAGAG intron-variant
rs887932 -- 2,048,599(+) CCTGA(G/T)TGGGG intron-variant
rs968387 -- 2,050,279(+) GCACA(G/T)GCCCC intron-variant
rs1064543 -- 2,037,847(-) TGTTT(G/T)TTTTT intron-variant, utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for MKNK2 Gene

Variant ID Type Subtype PubMed ID
nsv910499 CNV Loss 21882294
dgv3612n71 CNV Loss 21882294
dgv3614n71 CNV Loss 21882294
nsv470107 CNV Loss 18288195
nsv910593 CNV Loss 21882294
dgv3622n71 CNV Loss 21882294
nsv910600 CNV Loss 21882294
dgv3624n71 CNV Loss 21882294
dgv3625n71 CNV Loss 21882294
dgv3626n71 CNV Loss 21882294
dgv3627n71 CNV Gain+Loss 21882294
nsv910613 CNV Loss 21882294
dgv3628n71 CNV Loss 21882294
esv271907 CNV Insertion 20981092
nsv458325 CNV Loss 19166990

Relevant External Links for MKNK2 Gene

HapMap Linkage Disequilibrium report
MKNK2

Disorders for MKNK2 Gene

Relevant External Links for MKNK2

Genetic Association Database (GAD)
MKNK2
Human Genome Epidemiology (HuGE) Navigator
MKNK2
genes like me logo Genes that share disorders with MKNK2: view

No data available for UniProtKB/Swiss-Prot for MKNK2 Gene

Publications for MKNK2 Gene

  1. Identification of the human Mnk2 gene (MKNK2) through protein interaction with estrogen receptor beta. (PMID: 11013076) Slentz-Kesler K. … Weiner M.P. (Genomics 2000) 2 3 4 23
  2. The mitogen-activated protein kinase signal-integrating kinase Mnk2 is a eukaryotic initiation factor 4E kinase with high levels of basal activity in mammalian cells. (PMID: 11154262) Scheper G.C. … Proud C.G. (Mol. Cell. Biol. 2001) 3 4 23
  3. Regulation of arsenic trioxide-induced cellular responses by Mnk1 and Mnk2. (PMID: 18299328) Dolniak B. … Platanias L.C. (J. Biol. Chem. 2008) 3 4 23
  4. Negative regulation of protein translation by mitogen-activated protein kinase-interacting kinases 1 and 2. (PMID: 11463832) Knauf U. … Gram H. (Mol. Cell. Biol. 2001) 3 4
  5. The N and C termini of the splice variants of the human mitogen- activated protein kinase-interacting kinase Mnk2 determine activity and localization. (PMID: 12897141) Scheper G.C. … Proud C.G. (Mol. Cell. Biol. 2003) 3 4

Products for MKNK2 Gene

  • Addgene plasmids for MKNK2

Sources for MKNK2 Gene

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