Free for academic non-profit institutions. Other users need a Commercial license

Aliases for MKNK2 Gene

Aliases for MKNK2 Gene

  • MAP Kinase Interacting Serine/Threonine Kinase 2 2 3 5
  • MAP Kinase Signal-Integrating Kinase 2 3 4
  • G Protein-Coupled Receptor Kinase 7 2 3
  • MAPK Signal-Integrating Kinase 2 3 4
  • EC 2.7.11.1 4 61
  • GPRK7 3 4
  • MNK2 3 4
  • MAP Kinase-Interacting Serine/Threonine-Protein Kinase 2 3
  • Putative Map Kinase Interacting Kinase 2
  • EC 2.7.11 61

External Ids for MKNK2 Gene

Previous HGNC Symbols for MKNK2 Gene

  • GPRK7

Previous GeneCards Identifiers for MKNK2 Gene

  • GC19M002100
  • GC19M001977
  • GC19M001988
  • GC19M001809

Summaries for MKNK2 Gene

Entrez Gene Summary for MKNK2 Gene

  • This gene encodes a member of the calcium/calmodulin-dependent protein kinases (CAMK) Ser/Thr protein kinase family, which belongs to the protein kinase superfamily. This protein contains conserved DLG (asp-leu-gly) and ENIL (glu-asn-ile-leu) motifs, and an N-terminal polybasic region which binds importin A and the translation factor scaffold protein eukaryotic initiation factor 4G (eIF4G). This protein is one of the downstream kinases activated by mitogen-activated protein (MAP) kinases. It phosphorylates the eukaryotic initiation factor 4E (eIF4E), thus playing important roles in the initiation of mRNA translation, oncogenic transformation and malignant cell proliferation. In addition to eIF4E, this protein also interacts with von Hippel-Lindau tumor suppressor (VHL), ring-box 1 (Rbx1) and Cullin2 (Cul2), which are all components of the CBC(VHL) ubiquitin ligase E3 complex. Multiple alternatively spliced transcript variants have been found, but the full-length nature and biological activity of only two variants are determined. These two variants encode distinct isoforms which differ in activity and regulation, and in subcellular localization. [provided by RefSeq, Aug 2011]

GeneCards Summary for MKNK2 Gene

MKNK2 (MAP Kinase Interacting Serine/Threonine Kinase 2) is a Protein Coding gene. Among its related pathways are Translation Insulin regulation of translation and Akt Signaling. GO annotations related to this gene include transferase activity, transferring phosphorus-containing groups and protein tyrosine kinase activity. An important paralog of this gene is MKNK1.

UniProtKB/Swiss-Prot for MKNK2 Gene

  • Serine/threonine-protein kinase that phosphorylates SFPQ/PSF, HNRNPA1 and EIF4E. May play a role in the response to environmental stress and cytokines. Appears to regulate translation by phosphorylating EIF4E, thus increasing the affinity of this protein for the 7-methylguanosine-containing mRNA cap. Required for mediating PP2A-inhibition-induced EIF4E phosphorylation. Triggers EIF4E shuttling from cytoplasm to nucleus. Isoform 1 displays a high basal kinase activity, but isoform 2 exhibits a very low kinase activity. Acts as a mediator of the suppressive effects of IFNgamma on hematopoiesis. Negative regulator for signals that control generation of arsenic trioxide As(2)O(3)-dependent apoptosis and anti-leukemic responses. Involved in anti-apoptotic signaling in response to serum withdrawal.

Tocris Summary for MKNK2 Gene

  • Mitogen-activated protein kinase (MAPK) interacting protein kinases (Mnks) are a family of serine/threonine kinases. Mnks are downstream effectors of MAPK signaling, and have been implicated in oncogenic transformation and progression

Gene Wiki entry for MKNK2 Gene

No data available for PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MKNK2 Gene

Genomics for MKNK2 Gene

Regulatory Elements for MKNK2 Gene

Enhancers for MKNK2 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH19F002079 0.8 FANTOM5 ENCODE 18.5 -37.6 -37609 18.9 MLX CREB3L1 DMAP1 YBX1 SLC30A9 ZNF143 ZNF263 SP3 NFYC TBX21 SF3A2 CIRBP MKNK2 LINC01775 ENSG00000267063 ZNF77 C19orf24 BTBD2 SCAMP4 RPS15
GH19F002038 0.9 FANTOM5 ENCODE 14.2 +0.2 219 24.2 MLX CREB3L1 FEZF1 DMAP1 YBX1 YY1 SLC30A9 ZNF143 ZNF263 SP3 MKNK2 ENSG00000261526 CIRBP SF3A2 SCAMP4 RPS15 ZNF77 LOC100288123 C19orf35 MOB3A
GH19F001935 1.2 Ensembl ENCODE 12.3 +115.3 115340 1.8 HDGF ARNT ARID4B YBX1 ZNF2 ZNF48 CBX5 ZMIZ1 ZNF263 ZNF202 SF3A2 LOC100288123 TMEM259 CIRBP MKNK2 BTBD2 KLF16 MIR1909 REXO1 ATP8B3
GH19F001979 0.4 ENCODE 12.2 +70.5 70485 2.5 HIC1 SCRT2 ZBTB33 ZNF600 MNT KLF8 CSNK1G2-AS1 BTBD2 CSNK1G2 MKNK2 ENSG00000267283 GC19P001982
GH19F001988 1.1 ENCODE 12.2 +62.6 62588 0.2 CSNK1G2-AS1 BTBD2 CSNK1G2 MKNK2 ENSG00000267283 PIR36928
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around MKNK2 on UCSC Golden Path with GeneCards custom track

Promoters for MKNK2 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000341684 644 2001 HDGF PKNOX1 CREB3L1 WRNIP1 ARID4B SIN3A DMAP1 ZNF2 YY1 ZNF766

Genomic Location for MKNK2 Gene

Chromosome:
19
Start:
2,037,465 bp from pter
End:
2,051,244 bp from pter
Size:
13,780 bases
Orientation:
Minus strand

Genomic View for MKNK2 Gene

Genes around MKNK2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MKNK2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MKNK2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MKNK2 Gene

Proteins for MKNK2 Gene

  • Protein details for MKNK2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9HBH9-MKNK2_HUMAN
    Recommended name:
    MAP kinase-interacting serine/threonine-protein kinase 2
    Protein Accession:
    Q9HBH9
    Secondary Accessions:
    • Q6GPI3
    • Q9HBH8
    • Q9UHR0
    • Q9Y2N6

    Protein attributes for MKNK2 Gene

    Size:
    465 amino acids
    Molecular mass:
    51875 Da
    Cofactor:
    Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
    Cofactor:
    Name=Zn(2+); Xref=ChEBI:CHEBI:29105;
    Quaternary structure:
    • Monomer. Interacts with the C-terminal regions of EIF4G1 and EIF4G2; this interaction is promoted when MAPK pathways are repressed but repressed upon ERK proteins activation. Also binds to dephosphorylated MAPK3/ERK1 and MAPK1/ERK2. Isoform 1 interaction with phosphorylated MAPK3/ERK1 and MAPK1/ERK2 protects it from dephosphorylation and inactivation. Isoform 2 interacts with ESR2 and EIF4E in the nucleus.

    Three dimensional structures from OCA and Proteopedia for MKNK2 Gene

    Alternative splice isoforms for MKNK2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for MKNK2 Gene

Post-translational modifications for MKNK2 Gene

  • Dual phosphorylation of Thr-244 and Thr-249 activates the kinase. Phosphorylation of Thr-379 activates the kinase. Phosphorylated upon arsenic trioxide As(2)O(3) treatment. Phosphorylated by MAPK1/ERK2, MAPK11 and MAPK14. Dephosphorylated by PP2A.
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Domains & Families for MKNK2 Gene

Protein Domains for MKNK2 Gene

Graphical View of Domain Structure for InterPro Entry

Q9HBH9

UniProtKB/Swiss-Prot:

MKNK2_HUMAN :
  • Contains 1 protein kinase domain.
  • Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family.
Domain:
  • Contains 1 protein kinase domain.
Family:
  • Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family.
genes like me logo Genes that share domains with MKNK2: view

Function for MKNK2 Gene

Molecular function for MKNK2 Gene

UniProtKB/Swiss-Prot CatalyticActivity:
ATP + a protein = ADP + a phosphoprotein.
UniProtKB/Swiss-Prot EnzymeRegulation:
Inhibited by CGP57380 and staurosporine. Activated by phosphorylation in a negative-feedback regulatory manner in response to chemotherapy (e.g. cytarabine) and thus impairs the generation of antileukemic responses.
UniProtKB/Swiss-Prot Function:
Serine/threonine-protein kinase that phosphorylates SFPQ/PSF, HNRNPA1 and EIF4E. May play a role in the response to environmental stress and cytokines. Appears to regulate translation by phosphorylating EIF4E, thus increasing the affinity of this protein for the 7-methylguanosine-containing mRNA cap. Required for mediating PP2A-inhibition-induced EIF4E phosphorylation. Triggers EIF4E shuttling from cytoplasm to nucleus. Isoform 1 displays a high basal kinase activity, but isoform 2 exhibits a very low kinase activity. Acts as a mediator of the suppressive effects of IFNgamma on hematopoiesis. Negative regulator for signals that control generation of arsenic trioxide As(2)O(3)-dependent apoptosis and anti-leukemic responses. Involved in anti-apoptotic signaling in response to serum withdrawal.

Enzyme Numbers (IUBMB) for MKNK2 Gene

Gene Ontology (GO) - Molecular Function for MKNK2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004672 protein kinase activity IEA --
GO:0004674 protein serine/threonine kinase activity IEA,IDA 11463832
GO:0004683 calmodulin-dependent protein kinase activity IBA --
GO:0005515 protein binding IPI 20936779
GO:0005516 calmodulin binding IBA --
genes like me logo Genes that share ontologies with MKNK2: view
genes like me logo Genes that share phenotypes with MKNK2: view

Animal Models for MKNK2 Gene

MGI Knock Outs for MKNK2:

Animal Model Products

  • Taconic Biosciences Mouse Models for MKNK2

miRNA for MKNK2 Gene

miRTarBase miRNAs that target MKNK2

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for MKNK2

Flow Cytometry Products

No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for MKNK2 Gene

Localization for MKNK2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for MKNK2 Gene

Isoform 2: Nucleus, PML body.
Isoform 1: Cytoplasm.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for MKNK2 Gene COMPARTMENTS Subcellular localization image for MKNK2 gene
Compartment Confidence
nucleus 5
cytosol 3

Gene Ontology (GO) - Cellular Components for MKNK2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA --
GO:0005654 nucleoplasm IDA --
GO:0005730 nucleolus IDA --
GO:0005737 cytoplasm IEA,IBA --
GO:0016605 PML body IEA --
genes like me logo Genes that share ontologies with MKNK2: view

Pathways & Interactions for MKNK2 Gene

genes like me logo Genes that share pathways with MKNK2: view

Pathways by source for MKNK2 Gene

1 GeneGo (Thomson Reuters) pathway for MKNK2 Gene

SIGNOR curated interactions for MKNK2 Gene

Activates:
Is activated by:

Gene Ontology (GO) - Biological Process for MKNK2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006417 regulation of translation IEA --
GO:0006468 protein phosphorylation IDA,TAS 11463832
GO:0006915 apoptotic process IEA --
GO:0007166 cell surface receptor signaling pathway TAS 8415712
GO:0016310 phosphorylation IEA --
genes like me logo Genes that share ontologies with MKNK2: view

Drugs & Compounds for MKNK2 Gene

(5) Drugs for MKNK2 Gene - From: ApexBio, DGIdb, HMDB, and Tocris

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Adenosine triphosphate Approved Nutra 0
Cercosporamide Pharma Mnk2 and JAK3 inhibitor, Potent Mnk2 inhibitor 0
MNK1 INHIBITOR Pharma 0
Magnesium Nutra 0
CGP 57380 Pharma Selective inhibitor of Mnk1 0

(2) Additional Compounds for MKNK2 Gene - From: Tocris and HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
ADP
  • Adenosindiphosphorsaeure
  • Adenosine 5'-pyrophosphate
  • Adenosine diphosphate
  • Adenosine pyrophosphate
  • Adenosine-5'-diphosphate
Full agonist, Agonist 58-64-0
ETP 45835 dihydrochloride

(2) Tocris Compounds for MKNK2 Gene

Compound Action Cas Number
CGP 57380 Selective inhibitor of Mnk1 522629-08-9
ETP 45835 dihydrochloride Mnk1 and Mnk2 inhibitor

(1) ApexBio Compounds for MKNK2 Gene

Compound Action Cas Number
Cercosporamide Mnk2 and JAK3 inhibitor 131436-22-1
genes like me logo Genes that share compounds with MKNK2: view

Transcripts for MKNK2 Gene

Unigene Clusters for MKNK2 Gene

MAP kinase interacting serine/threonine kinase 2:
Representative Sequences:

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for MKNK2

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for MKNK2 Gene

ExUns: 1 ^ 2a · 2b · 2c ^ 3 ^ 4 ^ 5 ^ 6a · 6b ^ 7a · 7b ^ 8 ^ 9 ^ 10a · 10b · 10c ^ 11a · 11b · 11c ^ 12a · 12b ^ 13a · 13b ^ 14a · 14b
SP1: - - - - - -
SP2: - - - - - - - -
SP3: - -
SP4: - - - -
SP5:
SP6: - - - - -
SP7: - - -
SP8: - -
SP9:
SP10:

Relevant External Links for MKNK2 Gene

GeneLoc Exon Structure for
MKNK2
ECgene alternative splicing isoforms for
MKNK2

Expression for MKNK2 Gene

mRNA expression in normal human tissues for MKNK2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for MKNK2 Gene

This gene is overexpressed in Muscle - Skeletal (x13.1).

Protein differential expression in normal tissues from HIPED for MKNK2 Gene

This gene is overexpressed in Blymphocyte (55.1) and Placenta (13.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for MKNK2 Gene



Protein tissue co-expression partners for MKNK2 Gene

NURSA nuclear receptor signaling pathways regulating expression of MKNK2 Gene:

MKNK2

SOURCE GeneReport for Unigene cluster for MKNK2 Gene:

Hs.515032

mRNA Expression by UniProt/SwissProt for MKNK2 Gene:

Q9HBH9-MKNK2_HUMAN
Tissue specificity: Ubiquitously expressed in all tissues examined. Isoform 2 is expressed at higher levels in the ovary than is isoform 1.
genes like me logo Genes that share expression patterns with MKNK2: view

Primer Products

Orthologs for MKNK2 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for MKNK2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia MKNK2 34 35
  • 95.34 (n)
cow
(Bos Taurus)
Mammalia MKNK2 34 35
  • 90.88 (n)
dog
(Canis familiaris)
Mammalia MKNK2 34 35
  • 89.31 (n)
mouse
(Mus musculus)
Mammalia Mknk2 34 16 35
  • 88.67 (n)
rat
(Rattus norvegicus)
Mammalia Mknk2 34
  • 88.11 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia MKNK2 35
  • 84 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia MKNK2 35
  • 80 (a)
OneToOne
chicken
(Gallus gallus)
Aves MKNK2 34 35
  • 83.17 (n)
lizard
(Anolis carolinensis)
Reptilia MKNK2 35
  • 82 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia mknk2 34
  • 71.37 (n)
African clawed frog
(Xenopus laevis)
Amphibia MGC68447 34
zebrafish
(Danio rerio)
Actinopterygii mknk2a 35
  • 74 (a)
OneToMany
mknk2b 34 35
  • 72.5 (n)
-- 34
fruit fly
(Drosophila melanogaster)
Insecta Lk6 36 35
  • 61 (a)
worm
(Caenorhabditis elegans)
Secernentea mnk-1 34 35
  • 53.89 (n)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes RCK1 35
  • 22 (a)
ManyToMany
RCK2 35
  • 19 (a)
ManyToMany
sea squirt
(Ciona savignyi)
Ascidiacea CSA.11342 35
  • 58 (a)
OneToMany
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.15288 34
Species where no ortholog for MKNK2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for MKNK2 Gene

ENSEMBL:
Gene Tree for MKNK2 (if available)
TreeFam:
Gene Tree for MKNK2 (if available)

Paralogs for MKNK2 Gene

Variants for MKNK2 Gene

Sequence variations from dbSNP and Humsavar for MKNK2 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type
rs10294 -- 2,037,607(+) TTTTC(C/T)CCCAC utr-variant-3-prime
rs10415890 -- 2,037,237(+) GCCTT(G/T)GCCTC downstream-variant-500B
rs10416349 -- 2,037,441(+) TATGC(A/G)GTGAC downstream-variant-500B
rs10416516 -- 2,051,212(+) GACCC(C/T)TCTAC utr-variant-5-prime
rs1064543 -- 2,037,847(-) TGTTT(G/T)TTTTT intron-variant, utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for MKNK2 Gene

Variant ID Type Subtype PubMed ID
esv3419044 CNV insertion 20981092
esv3583202 CNV loss 25503493
esv3583203 CNV loss 25503493
esv3643414 CNV gain 21293372
esv3893156 CNV loss 25118596
nsv458325 CNV loss 19166990
nsv470107 CNV loss 18288195
nsv578380 CNV loss 21841781
nsv953942 CNV deletion 24416366

Variation tolerance for MKNK2 Gene

Residual Variation Intolerance Score: 51.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 5.41; 71.23% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for MKNK2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MKNK2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MKNK2 Gene

Disorders for MKNK2 Gene

Relevant External Links for MKNK2

Genetic Association Database (GAD)
MKNK2
Human Genome Epidemiology (HuGE) Navigator
MKNK2
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
MKNK2

No disorders were found for MKNK2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MKNK2 Gene

Publications for MKNK2 Gene

  1. Identification of the human Mnk2 gene (MKNK2) through protein interaction with estrogen receptor beta. (PMID: 11013076) Slentz-Kesler K. … Weiner M.P. (Genomics 2000) 2 3 4 22 64
  2. Regulation of arsenic trioxide-induced cellular responses by Mnk1 and Mnk2. (PMID: 18299328) Dolniak B. … Platanias L.C. (J. Biol. Chem. 2008) 3 4 22 64
  3. The mitogen-activated protein kinase signal-integrating kinase Mnk2 is a eukaryotic initiation factor 4E kinase with high levels of basal activity in mammalian cells. (PMID: 11154262) Scheper G.C. … Proud C.G. (Mol. Cell. Biol. 2001) 3 4 22 64
  4. Essential role for Mnk kinases in type II interferon (IFNgamma) signaling and its suppressive effects on normal hematopoiesis. (PMID: 21149447) Joshi S. … Platanias L.C. (J. Biol. Chem. 2011) 3 4 64
  5. The Mnks: MAP kinase-interacting kinases (MAP kinase signal- integrating kinases). (PMID: 18508592) Buxade M. … Proud C.G. (Front. Biosci. 2008) 3 4 64

Products for MKNK2 Gene

Sources for MKNK2 Gene

Content
Loading form....