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MKNK1 Gene

protein-coding   GIFtS: 69
GCID: GC01M047023

MAP Kinase Interacting Serine/Threonine Kinase 1

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
MAP Kinase Interacting Serine/Threonine Kinase 11 2     EC 2.7.11.13 8
MNK12 3 5     MAP Kinase-Interacting Serine/Threonine-Protein Kinase 12
MAP Kinase Signal-Integrating Kinase 12 3     Mnk13
MAPK Signal-Integrating Kinase 12 3     EC 2.7.118

External Ids:    HGNC: 71101   Entrez Gene: 85692   Ensembl: ENSG000000792777   OMIM: 6067245   UniProtKB: Q9BUB53   

Export aliases for MKNK1 gene to outside databases

Previous GC identifers: GC01M046717 GC01M045980 GC01M046409 GC01M046393 GC01M046735 GC01M046795 GC01M045139


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for MKNK1 Gene:
This gene encodes a Ser/Thr protein kinase that interacts with, and is activated by ERK1 and p38 mitogen-activated
protein kinases, and thus may play a role in the response to environmental stress and cytokines. This kinase may
also regulate transcription by phosphorylating eIF4E via interaction with the C-terminal region of eIF4G.
Alternatively spliced transcript variants have been noted for this gene. (provided by RefSeq, Jan 2012)

GeneCards Summary for MKNK1 Gene:
MKNK1 (MAP kinase interacting serine/threonine kinase 1) is a protein-coding gene. Diseases associated with MKNK1 include cutaneous t cell lymphoma, and fanconi's anemia. GO annotations related to this gene include protein serine/threonine kinase activity. An important paralog of this gene is RPS6KA6.

UniProtKB/Swiss-Prot: MKNK1_HUMAN, Q9BUB5
Function: May play a role in the response to environmental stress and cytokines. Appears to regulate translation
by phosphorylating EIF4E, thus increasing the affinity of this protein for the 7-methylguanosine-containing mRNA
cap

Gene Wiki entry for MKNK1 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000001.11  NT_032977.10  NC_018912.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the MKNK1 gene promoter:
         PPAR-alpha   AP-1   SRF (504 AA)   ATF-2   Nkx2-5   c-Jun   ATF   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidMKNK1 promoter sequence
   Search Chromatin IP Primers for MKNK1

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat MKNK1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1p33   Ensembl cytogenetic band:  1p33   HGNC cytogenetic band: 1p33

MKNK1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
MKNK1 gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01M047023:  view genomic region     (about GC identifiers)

Start:
47,023,090 bp from pter      End:
47,082,515 bp from pter
Size:
59,426 bases      Orientation:
minus strand
ORGUL member locations:
Legend (see complete legend)

ORGUL Member Locations for MKNK1

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: MKNK1_HUMAN, Q9BUB5 (See protein sequence)
Recommended Name: MAP kinase-interacting serine/threonine-protein kinase 1  
Size: 465 amino acids; 51342 Da
Cofactor: Magnesium
Subunit: Interacts with the C-terminal regions of EIF4G1 and EIF4G2. Also binds to dephosphorylated ERK1 and ERK2,
and to the p38 kinases
2 PDB 3D structures from and Proteopedia for MKNK1:
2HW6 (3D)        2Y9Q (3D)    
Secondary accessions: D3DQ20 D3DQ21 O00312 Q5TC06 Q5TC07 Q6V0N6
Alternative splicing: 3 isoforms:  Q9BUB5-1   Q9BUB5-2   Q9BUB5-3   

Explore the universe of human proteins at neXtProt for MKNK1: NX_Q9BUB5

Explore proteomics data for MKNK1 at MOPED

Post-translational modifications: 

  • Dual phosphorylation of Thr-250 and Thr-255 activates the kinase. Phosphorylation of Thr-385 activates the kinase.
    MAPK3/ERK1 is one of the kinases which activate MKNK1/MNK1. Phosphorylation by PAK2 leads to a reduced
    phosphorylation of EIF4G11
  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus
  • Selected DME Specific Peptides for MKNK1 (Q9BUB5) (see all 16)
     DLWSLGV  QVLQHPW  KDWAHIS  RDLKPEN 


    See MKNK1 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (3 alternative transcripts): 
    NP_001129025.1  NP_003675.2  NP_945324.1  

    ENSEMBL proteins: 
     ENSP00000339197   ENSP00000361014   ENSP00000361013   ENSP00000435069   ENSP00000433038  
     ENSP00000411135   ENSP00000434493   ENSP00000431837   ENSP00000436709   ENSP00000432665  
     ENSP00000434051   ENSP00000435163   ENSP00000434021   ENSP00000434834   ENSP00000432369  
     ENSP00000431985   ENSP00000361012   ENSP00000339573   ENSP00000440974  
    Reactome Protein details: Q9BUB5

    MKNK1 Human Recombinant Protein Products:

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    Novus Biologicals MKNK1 Proteins
    Novus Biologicals MKNK1 Lysate
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    Cloud-Clone Corp. Proteins for MKNK1

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    MKNK1 Assay Products:

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    IUPHAR Guide to PHARMACOLOGY protein family classification: MAP kinase interacting serine/threonine kinase 1
    MKN subfamily

    5 InterPro protein domains:
     IPR017441 Protein_kinase_ATP_BS
     IPR002290 Ser/Thr_dual-sp_kinase_dom
     IPR011009 Kinase-like_dom
     IPR008271 Ser/Thr_kinase_AS
     IPR000719 Prot_kinase_dom

    Graphical View of Domain Structure for InterPro Entry Q9BUB5

    ProtoNet protein and cluster: Q9BUB5

    UniProtKB/Swiss-Prot: MKNK1_HUMAN, Q9BUB5
    Similarity: Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family
    Similarity: Contains 1 protein kinase domain


    MKNK1 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: MKNK1_HUMAN, Q9BUB5
    Function: May play a role in the response to environmental stress and cytokines. Appears to regulate translation
    by phosphorylating EIF4E, thus increasing the affinity of this protein for the 7-methylguanosine-containing mRNA
    cap
    Catalytic activity: ATP + a protein = ADP + a phosphoprotein
    Enzyme regulation: Phosphorylated and activated by the p38 kinases and kinases in the Erk pathway

         Enzyme Numbers (IUBMB): EC 2.7.11.11 2 EC 2.7.112

         Gene Ontology (GO): Selected molecular function terms (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004672protein kinase activity ----
    GO:0004674protein serine/threonine kinase activity IDA17130135
    GO:0004713protein tyrosine kinase activity ----
    GO:0005515protein binding IPI--
    GO:0005524ATP binding IDA9155018
         
    MKNK1 for ontologies           About GeneDecksing


    Phenotypes:
         5 GenomeRNAi human phenotypes for MKNK1:
     Decreased homologous recombina  Decreased substrate adherent c  Decreased viability with TRAIL  Increased cell death HMECs cel 
     Lamellipodia cells 

         1 MGI mutant phenotype (inferred from 1 allele(MGI details for Mknk1):
     normal 

    MKNK1 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Mknk1tm1Fuku for MKNK1

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for MKNK1
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       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for MKNK1
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for MKNK1

    miRNA
    Products:
        
    miRTarBase miRNAs that target MKNK1:
    hsa-mir-26b-5p (MIRT029104)

    Block miRNA regulation of human, mouse, rat MKNK1 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate MKNK1 (see all 27):
    hsa-miR-1287 hsa-miR-15a hsa-miR-503 hsa-miR-218 hsa-miR-1205 hsa-miR-888* hsa-miR-3916 hsa-miR-3125
    SwitchGear 3'UTR luciferase reporter plasmidMKNK1 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat MKNK1

    Gene Editing
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    GenScript: all cDNA clones in your preferred vector (see all 3): MKNK1 (NM_003684)
    Sino Biological Human cDNA Clone for MKNK1
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for MKNK1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MKNK1

    Cell Line
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    Browse ESI BIO Cell Lines and PureStem Progenitors for MKNK1 
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MKNK1


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    MKNK1_HUMAN, Q9BUB5: Isoform 2: Cytoplasm
    MKNK1_HUMAN, Q9BUB5: Isoform 3: Cytoplasm. Nucleus
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus5
    cytosol4

    Gene Ontology (GO): 3 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IEA--
    GO:0005829cytosol TAS--
    GO:0016020membrane ----

    MKNK1 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for MKNK1 About   (see all 13)  
    See pathways by source

    SuperPathContained pathways About
    1Translation Insulin regulation of translation
    Transcription Receptor mediated HIF regulation0.51
    Insulin signaling pathway0.32
    Translation Regulation activity of EIF4F0.44
    2Signaling by FGFR
    Signaling by FGFR0.91
    Signaling by FGFR in disease0.91
    3ERK Signaling
    ERK Signaling0.61
    MAPK Signaling0.58
    4FGFR ligand binding and activation
    Negative regulation of FGFR signaling0.56
    Spry regulation of FGF signaling0.00
    5TGF-Beta Pathway
    MAPK Family Pathway0.60
    Regulation of eIF4 and p70S6K0.43

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    5 Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for MKNK1
        MAPK Signaling
    ERK Signaling
    p38 Signaling
    Regulation of eIF4 and p70S6K
    MAPK Family Pathway

    1 Cell Signaling Technology (CST) Pathway for MKNK1
        Translational Control

    2 GeneGo (Thomson Reuters) Pathways for MKNK1
        Transcription Receptor-mediated HIF regulation
    Translation Regulation of EIF4F activity

    2 BioSystems Pathways for MKNK1
        p38 MAPK Signaling Pathway
    Signaling mediated by p38-alpha and p38-beta


    1 Reactome Pathway for MKNK1
        Spry regulation of FGF signaling


    3 Kegg Pathways  (Kegg details for MKNK1):
        MAPK signaling pathway
    HIF-1 signaling pathway
    Insulin signaling pathway


    MKNK1 for pathways           About GeneDecksing

        Pathway & Disease-focused RT2 Profiler PCR Arrays including MKNK1: 
              EGF / PDGF Signaling Pathway in human mouse rat
              MAP Kinase (MAPK) Signaling Pathway in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for MKNK1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for MKNK1 (Q9BUB51, 2, 3 ENSP000003610144) via UniProtKB, MINT, STRING, and/or I2D (see all 72)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    DDAH2O958652, 3MINT-8263137 I2D: score=2 
    ENSG00000206395O958652, 3MINT-8263137 I2D: score=2 
    ENSG00000225635O958652, 3MINT-8263137 I2D: score=2 
    ENSG00000226634O958652, 3MINT-8263137 I2D: score=2 
    ENSG00000227317O958652, 3MINT-8263137 I2D: score=2 
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 8):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006417regulation of translation IEA--
    GO:0006468protein phosphorylation IDA9155018
    GO:0008543fibroblast growth factor receptor signaling pathway TAS--
    GO:0009103lipopolysaccharide biosynthetic process ----
    GO:0009651response to salt stress IEA--

    MKNK1 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Compounds for MKNK1 available from Tocris Bioscience    About this table
    CompoundAction CAS #
    PF 3644022Potent MK2 inhibitor[1276121-88-0]
    NQDI 1Inhibitor of apoptosis signal-regulating kinase 1 (ASK1)[175026-96-7]
    HI TOPK 032Selective T-LAK-cell-originated protein kinase (TOPK) inhibitor[487020-03-1]

    3 HMDB Compounds for MKNK1    About this table
    CompoundSynonyms CAS #PubMed Ids
    ADPadenosindiphosphorsaeure (see all 8)58-64-0--
    Adenosine triphosphate5'-(tetrahydrogen triphosphate) Adenosine (see all 24)56-65-5--
    MagnesiumMagnesium (see all 2)7439-95-4--

    5 Novoseek inferred chemical compound relationships for MKNK1 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    anisomycin 66.5 1 18081851 (1)
    sb 203580 51.4 3 12781867 (1), 11154262 (1)
    serine 13.8 2 16479008 (2)
    alanine 5.43 1 16479008 (1)
    h2o2 4.63 2 15234964 (1), 9545260 (1)



    MKNK1 for compounds           About GeneDecksing



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for MKNK1 gene (3 alternative transcripts): 
    NM_001135553.2  NM_003684.5  NM_198973.3  

    Unigene Cluster for MKNK1:

    MAP kinase interacting serine/threonine kinase 1
    Hs.371594  [show with all ESTs]
    Unigene Representative Sequence: BX648559
    Selected Ensembl transcripts including schematic representations, and UCSC links where relevant (see all 30):
    ENST00000342571 ENST00000371946(uc001cqb.3) ENST00000371945 ENST00000524749
    ENST00000528077 ENST00000428112 ENST00000532897 ENST00000530528 ENST00000531355(uc009vyj.3)
    ENST00000470237 ENST00000524417 ENST00000460098 ENST00000532783 ENST00000496619
    ENST00000528237 ENST00000526513 ENST00000484301 ENST00000486716
    miRNA
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    Selected qRT-PCR Assays for microRNAs that regulate MKNK1 (see all 27):
    hsa-miR-1287 hsa-miR-15a hsa-miR-503 hsa-miR-218 hsa-miR-1205 hsa-miR-888* hsa-miR-3916 hsa-miR-3125
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    Inhib. RNA
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    Additional mRNA sequence: 

    AB000409.1 AB451300.1 AB451432.1 AK096423.1 AK096986.1 AK290456.1 AK298839.1 AK304005.1 
    AK310566.1 AY355461.1 BC002755.2 BX538193.1 BX648559.1 NR_024174.2 NR_024176.2 

    17 DOTS entries:

    DT.452391  DT.101981563  DT.91877780  DT.121383495  DT.40297741  DT.95171717  DT.95134959  DT.75103234 
    DT.121383562  DT.121383571  DT.100816752  DT.121383510  DT.121383572  DT.75103235  DT.92427371  DT.121383576 
    DT.75111000 

    Selected AceView cDNA sequences (see all 172):

    AW001842 BE646536 BM504648 AI990929 AA677144 AA313255 AA479941 AA252122 
    CR605253 AI742748 AI149714 AI953314 AW151999 AI379421 AA716483 AW468056 
    BQ772898 AA600072 AA242789 H42772 AA417316 AL544441 BQ962661 CR603808 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for MKNK1 (see all 13)    About this scheme

    ExUns: 1a · 1b · 1c ^ 2 ^ 3a · 3b ^ 4 ^ 5a · 5b ^ 6 ^ 7 ^ 8a · 8b ^ 9a · 9b ^ 10 ^ 11a · 11b ^ 12 ^ 13 ^ 14 ^ 15a · 15b ^ 16a · 16b ^ 17a ·
    SP1:                                      -     -     -     -                 -           -           -                       -     -                           
    SP2:                    -                 -     -     -     -                 -           -           -           -           -     -                           
    SP3:                                      -     -     -     -                 -           -           -           -           -     -                           
    SP4:                                                        -                 -           -     -     -           -           -     -                           
    SP5:                    -                 -                 -                 -           -           -           -           -     -     -     -     -     -   

    ExUns: 17b ^ 18 ^ 19a · 19b · 19c
    SP1:                              
    SP2:                              
    SP3:        -                     
    SP4:                              
    SP5:  -                           


    ECgene alternative splicing isoforms for MKNK1

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    MKNK1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: AAGGTACAGC
    MKNK1 Expression
    About this image


    MKNK1 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 3) fully expand
     
     Thymus (Hematopoietic System)    fully expand to see all 2 entries
             Double Positive Thymocytes Thymus
             Thymus
     
     Liver (Hepatobiliary System)
             Liver Lobule
     
     Blood (Cardiovascular System)
             Double Positive Thymocytes Thymus
    MKNK1 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    MKNK1 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.371594

    UniProtKB/Swiss-Prot: MKNK1_HUMAN, Q9BUB5
    Tissue specificity: Ubiquitous

        Pathway & Disease-focused RT2 Profiler PCR Arrays including MKNK1: 
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              MAP Kinase (MAPK) Signaling Pathway in human mouse rat

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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals and fungi.

    Orthologs for MKNK1 gene from Selected species (see all 16)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Mknk11 , 5 MAP kinase-interacting serine/threonine kinase 11, 5 88.02(n)1
    93.89(a)1
      4 (53.06 cM)5
    173461  NM_001285487.11  NP_001272416.11 
     1158391985 
    chicken
    (Gallus gallus)
    Aves MKNK11 MAP kinase interacting serine/threonine kinase 1 75.96(n)
    86.06(a)
      771961  XM_004936768.1  XP_004936825.1 
    lizard
    (Anolis carolinensis)
    Reptilia MKNK16
    MAP kinase interacting serine/threonine kinase 1
    75(a)
    1 ↔ 1
    4(112617863-112664205)
    African clawed frog
    (Xenopus laevis)
    Amphibia mnk12 MAP kinase-interacting kinase 1 77.38(n)    AB023807.1 
    zebrafish
    (Danio rerio)
    Actinopterygii mknk11 MAP kinase interacting serine/threonine kinase 1 72.12(n)
    78.34(a)
      555974  NM_001114739.2  NP_001108211.2 
    fruit fly
    (Drosophila melanogaster)
    Insecta Lk61 , 3 microtubule-based process protein
    kinase3
    Lk61
    47(a)3
    60.32(n)1
    59.52(a)1
      3 86F63
    446721  NM_143729.21  NP_651986.21 
    worm
    (Caenorhabditis elegans)
    Secernentea mnk-16
    Protein MNK-1, isoform b (mnk-1) mRNA, complete cd...
    27(a)
    1 → many
    II(10544210-10555044) WBGene00011304
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes RCK16
    RCK26
    Protein kinase involved in the response to oxidati...
    Protein kinase involved in the response to oxidati...
    23(a)
    19(a)
    many ↔ many
    many ↔ many
    VII(207033-208571) YGL158W
    XII(634252-636084) YLR248W


    ENSEMBL Gene Tree for MKNK1 (if available)
    TreeFam Gene Tree for MKNK1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for MKNK1 gene
    RPS6KA62  MAPKAPK32  MAPKAPK52  RPS6KA12  RPS6KA52  MAPKAPK22  RPS6KA42  MKNK22  
    RPS6KA32  RPS6KA22  
    Selected SIMAP similar genes for MKNK1 using alignment to 17 protein entries:     MKNK1_HUMAN (see all proteins) (see all similar genes):
    DKFZp686E14208    DKFZp586A1021    MKNK2    PLK4    STK17A    CAMK2A
    CAMK2B    PHKG2    TSSK6    AURKB    PRKACA    RPS6KA2
    STK32A    DAPK3    MARK2    RPS6KA1    DCLK2    DKFZp564L2416

    MKNK1 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for MKNK1 (see all 1012)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 1 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs590766411,2
    C--47045562(+) TTTTTT/-CTGAG 5 -- int11Minor allele frequency- -:0.50CSA 2
    rs609147011,2
    C--47046466(+) GAGGA-/CCCAGT 5 -- int10--------
    rs360996001,2
    C--47047181(+) AAAAA-/ATTGGT 5 -- int12Minor allele frequency- A:0.25NA 4
    rs680171811,2
    C--47047181(+) TATCA-/A/AA  
            
    AAAAA
    5 -- int10--------
    rs358989531,2
    C--47049523(+) CAATAG/-GGCTG 5 -- int11Minor allele frequency- -:0.50CSA 2
    rs578878851,2
    C--47052337(+) ATCCT-/GAAA  
            
    GAAAC
    5 -- int10--------
    rs790701601,2
    C--47055670(+) TCCTC-/TCCCAAC 5 -- int10--------
    rs113128711,2
    C--47062973(+) AGAGCA/-AAAAA 5 -- int1 trp31Minor allele frequency- -:0.00NA 2
    rs572896611,2
    C--47065634(+) CTTCT-/TCTCCTCA 5 -- int10--------
    rs581698991,2
    C--47068340(+) TATTG-/CTATT 
    G
    /GCTATT
    TTAAT
    8 -- cds1 int11NA 2

    HapMap Linkage Disequilibrium report for MKNK1 (47023090 - 47082515 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 1 variation for MKNK1:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv755CNV Insertion18451855

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing MKNK1
    DNA2.0 Custom Variant and Variant Library Synthesis for MKNK1

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 606724    OMIM disorders: --

    14 diseases for MKNK1:    
    About MalaCards
    cutaneous t cell lymphoma    fanconi's anemia    chronic myeloid leukemia    hepatitis c virus
    hypoxia    rheumatoid arthritis    arthritis    hepatitis c
    myeloid leukemia    endotheliitis    breast cancer    hepatitis
    leukemia    neuronitis


    MKNK1 for disorders           About GeneDecksing

    2 Novoseek inferred disease relationships for MKNK1 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    shock 9.56 3 9545260 (1), 10859165 (1)
    cancer 0 4 15516979 (1), 20145189 (1)

    Genetic Association Database (GAD): MKNK1
    Human Genome Epidemiology (HuGE) Navigator: MKNK1 (2 documents)

    Export disorders for MKNK1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for MKNK1 gene, integrated from 10 sources (see all 77):
    (articles sorted by number of sources associating them with MKNK1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. MNK1, a new MAP kinase-activated protein kinase, isolated by a novel expression screening method for identifying protein kinase substrates. (PubMed id 9155018)1, 2, 3 Fukunaga R. and Hunter T. (EMBO J. 1997)
    2. Phosphorylation of Mnk1 by caspase-activated Pak2/gamma-PAK inhibits phosphorylation and interaction of eIF4G with Mnk. (PubMed id 15234964)1, 2, 9 Orton K.C.... Traugh J.A. (J. Biol. Chem. 2004)
    3. Human eukaryotic translation initiation factor 4G (eIF4G) recruits mnk1 to phosphorylate eIF4E. (PubMed id 9878069)1, 2, 9 Pyronnet S....Sonenberg N. (EMBO J. 1999)
    4. Genetic variants within the MAP kinase signalling network and anti-TNF treatment response in rheumatoid arthritis patients. (PubMed id 20805296)1, 4 Coulthard L.R....McDermott M.F. (Ann. Rheum. Dis. 2011)
    5. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (Mol. Med. 2010)
    6. The DNA sequence and biological annotation of human chromosome 1. (PubMed id 16710414)1, 2 Gregory S.G.... Bentley D.R. (Nature 2006)
    7. Identification and molecular characterization of Mnk1b, a splice variant of human MAP kinase-interacting kinase Mnk1. (PubMed id 15350534)1, 2 O'Loghlen A.... Martin M.E. (Exp. Cell Res. 2004)
    8. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    9. Negative regulation of protein translation by mitogen-activated protein kinase-interacting kinases 1 and 2. (PubMed id 11463832)1, 2 Knauf U.... Gram H. (Mol. Cell. Biol. 2001)
    10. The serine-threonine kinase MNK1 is post-translationally stabilized by PML-RARalpha and regulates differentiation of hematopoietic cells. (PubMed id 15516979)1, 9 Worch J....MA1ller-Tidow C. (Oncogene 2004)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 8569 HGNC: 7110 AceView: MKNK1 Ensembl:ENSG00000079277 euGenes: HUgn8569
    ECgene: MKNK1 Kegg: 8569 H-InvDB: MKNK1

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for MKNK1 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for MKNK1 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for MKNK1 gene:
    Search GeneIP for patents involving MKNK1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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