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Aliases for MKNK1 Gene

Aliases for MKNK1 Gene

  • MAP Kinase Interacting Serine/Threonine Kinase 1 2 3 5
  • MAP Kinase Signal-Integrating Kinase 1 3 4
  • MAPK Signal-Integrating Kinase 1 3 4
  • EC 2.7.11.1 4 63
  • MNK1 3 4
  • EC 2.7.11 63

External Ids for MKNK1 Gene

Previous GeneCards Identifiers for MKNK1 Gene

  • GC01M046717
  • GC01M045980
  • GC01M046409
  • GC01M046393
  • GC01M046735
  • GC01M046795
  • GC01M047023
  • GC01M045139

Summaries for MKNK1 Gene

Entrez Gene Summary for MKNK1 Gene

  • This gene encodes a Ser/Thr protein kinase that interacts with, and is activated by ERK1 and p38 mitogen-activated protein kinases, and thus may play a role in the response to environmental stress and cytokines. This kinase may also regulate transcription by phosphorylating eIF4E via interaction with the C-terminal region of eIF4G. Alternatively spliced transcript variants have been noted for this gene. [provided by RefSeq, Jan 2012]

GeneCards Summary for MKNK1 Gene

MKNK1 (MAP Kinase Interacting Serine/Threonine Kinase 1) is a Protein Coding gene. Among its related pathways are Signaling by GPCR and Translation Insulin regulation of translation. GO annotations related to this gene include transferase activity, transferring phosphorus-containing groups and protein tyrosine kinase activity. An important paralog of this gene is MAPKAPK5.

UniProtKB/Swiss-Prot for MKNK1 Gene

  • May play a role in the response to environmental stress and cytokines. Appears to regulate translation by phosphorylating EIF4E, thus increasing the affinity of this protein for the 7-methylguanosine-containing mRNA cap.

Tocris Summary for MKNK1 Gene

  • Mitogen-activated protein kinase (MAPK) interacting protein kinases (Mnks) are a family of serine/threonine kinases. Mnks are downstream effectors of MAPK signaling, and have been implicated in oncogenic transformation and progression

Gene Wiki entry for MKNK1 Gene

No data available for PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MKNK1 Gene

Genomics for MKNK1 Gene

Regulatory Elements for MKNK1 Gene

Promoters for MKNK1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around MKNK1 on UCSC Golden Path with GeneCards custom track

Genomic Location for MKNK1 Gene

Chromosome:
1
Start:
46,557,407 bp from pter
End:
46,616,843 bp from pter
Size:
59,437 bases
Orientation:
Minus strand

Genomic View for MKNK1 Gene

Genes around MKNK1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MKNK1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MKNK1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MKNK1 Gene

Proteins for MKNK1 Gene

  • Protein details for MKNK1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9BUB5-MKNK1_HUMAN
    Recommended name:
    MAP kinase-interacting serine/threonine-protein kinase 1
    Protein Accession:
    Q9BUB5
    Secondary Accessions:
    • D3DQ20
    • D3DQ21
    • O00312
    • Q5TC06
    • Q5TC07
    • Q6V0N6

    Protein attributes for MKNK1 Gene

    Size:
    465 amino acids
    Molecular mass:
    51342 Da
    Cofactor:
    Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
    Quaternary structure:
    • Interacts with the C-terminal regions of EIF4G1 and EIF4G2. Also binds to dephosphorylated ERK1 and ERK2, and to the p38 kinases.

    Three dimensional structures from OCA and Proteopedia for MKNK1 Gene

    Alternative splice isoforms for MKNK1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for MKNK1 Gene

Proteomics data for MKNK1 Gene at MOPED

Post-translational modifications for MKNK1 Gene

  • Dual phosphorylation of Thr-250 and Thr-255 activates the kinase. Phosphorylation of Thr-385 activates the kinase. MAPK3/ERK1 is one of the kinases which activate MKNK1/MNK1. Phosphorylation by PAK2 leads to a reduced phosphorylation of EIF4G1.
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Antibody Products

  • Cell Signaling Technology (CST) Antibodies for MKNK1 (Mnk1)

Domains & Families for MKNK1 Gene

Graphical View of Domain Structure for InterPro Entry

Q9BUB5

UniProtKB/Swiss-Prot:

MKNK1_HUMAN :
  • Contains 1 protein kinase domain.
  • Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family.
Domain:
  • Contains 1 protein kinase domain.
Family:
  • Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family.
genes like me logo Genes that share domains with MKNK1: view

Function for MKNK1 Gene

Molecular function for MKNK1 Gene

UniProtKB/Swiss-Prot CatalyticActivity:
ATP + a protein = ADP + a phosphoprotein.
UniProtKB/Swiss-Prot EnzymeRegulation:
Phosphorylated and activated by the p38 kinases and kinases in the Erk pathway.
UniProtKB/Swiss-Prot Function:
May play a role in the response to environmental stress and cytokines. Appears to regulate translation by phosphorylating EIF4E, thus increasing the affinity of this protein for the 7-methylguanosine-containing mRNA cap.

Enzyme Numbers (IUBMB) for MKNK1 Gene

Gene Ontology (GO) - Molecular Function for MKNK1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004674 protein serine/threonine kinase activity IEA,TAS --
GO:0005516 calmodulin binding IBA --
GO:0005524 ATP binding IEA,IDA 9155018
genes like me logo Genes that share ontologies with MKNK1: view
genes like me logo Genes that share phenotypes with MKNK1: view

Animal Models for MKNK1 Gene

MGI Knock Outs for MKNK1:

Animal Model Products

CRISPR Products

miRNA for MKNK1 Gene

miRTarBase miRNAs that target MKNK1

Inhibitory RNA Products

In Situ Assay Products

Flow Cytometry Products

No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for MKNK1 Gene

Localization for MKNK1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for MKNK1 Gene

Isoform 2: Cytoplasm.
Isoform 3: Cytoplasm. Nucleus.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for MKNK1 Gene COMPARTMENTS Subcellular localization image for MKNK1 gene
Compartment Confidence
cytosol 5
nucleus 5

Gene Ontology (GO) - Cellular Components for MKNK1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IBA --
genes like me logo Genes that share ontologies with MKNK1: view

Pathways & Interactions for MKNK1 Gene

genes like me logo Genes that share pathways with MKNK1: view

SIGNOR curated interactions for MKNK1 Gene

Activates:
Inactivates:
Is activated by:
Is inactivated by:

Gene Ontology (GO) - Biological Process for MKNK1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006417 regulation of translation IEA --
GO:0006468 protein phosphorylation IEA,IDA 9155018
GO:0008543 fibroblast growth factor receptor signaling pathway TAS --
genes like me logo Genes that share ontologies with MKNK1: view

Drugs & Compounds for MKNK1 Gene

(8) Drugs for MKNK1 Gene - From: HMDB, ApexBio, Tocris, Novoseek, and DGIdb

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Adenosine triphosphate Approved Nutra 0
CGP 57380 Pharma Selective inhibitor of Mnk1 0
MNK1 INHIBITOR Pharma 0
Magnesium Nutra 0

(4) Additional Compounds for MKNK1 Gene - From: HMDB, Tocris, and Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
ADP
  • Adenosindiphosphorsaeure
  • Adenosine 5'-pyrophosphate
  • Adenosine diphosphate
  • Adenosine pyrophosphate
  • Adenosine-5'-diphosphate
Full agonist, Agonist 58-64-0
Cercosporamide
131436-22-1
ETP 45835 dihydrochloride
genes like me logo Genes that share compounds with MKNK1: view

Transcripts for MKNK1 Gene

Unigene Clusters for MKNK1 Gene

MAP kinase interacting serine/threonine kinase 1:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for MKNK1 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3a · 3b ^ 4 ^ 5a · 5b ^ 6 ^ 7 ^ 8a · 8b ^ 9a · 9b ^ 10 ^ 11a · 11b ^ 12 ^ 13 ^ 14 ^ 15a · 15b ^ 16a · 16b ^ 17a ·
SP1: - - - - - - - - -
SP2: - - - - - - - - - - -
SP3: - - - - - - - - - -
SP4: - - - - - - - -
SP5: - - - - - - - - - - - - -
SP6: - - -
SP7: - -
SP8: - -
SP9: -
SP10: - - - -
SP11: - - - -
SP12: -
SP13:

ExUns: 17b ^ 18 ^ 19a · 19b · 19c
SP1:
SP2:
SP3: -
SP4:
SP5: -
SP6: -
SP7:
SP8:
SP9:
SP10:
SP11:
SP12:
SP13:

Relevant External Links for MKNK1 Gene

GeneLoc Exon Structure for
MKNK1
ECgene alternative splicing isoforms for
MKNK1

Expression for MKNK1 Gene

mRNA expression in normal human tissues for MKNK1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for MKNK1 Gene

This gene is overexpressed in Whole Blood (x11.0) and Pancreas (x4.4).

Protein differential expression in normal tissues from HIPED for MKNK1 Gene

This gene is overexpressed in Pancreas (51.1) and CD8 Tcells (7.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for MKNK1 Gene



SOURCE GeneReport for Unigene cluster for MKNK1 Gene Hs.371594

mRNA Expression by UniProt/SwissProt for MKNK1 Gene

Q9BUB5-MKNK1_HUMAN
Tissue specificity: Ubiquitous.
genes like me logo Genes that share expression patterns with MKNK1: view

Protein tissue co-expression partners for MKNK1 Gene

Primer Products

In Situ Assay Products

Orthologs for MKNK1 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for MKNK1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia MKNK1 35
  • 99.26 (n)
  • 99.34 (a)
cow
(Bos Taurus)
Mammalia MKNK1 35
  • 91.44 (n)
  • 93.58 (a)
MKNK1 36
  • 91 (a)
OneToOne
dog
(Canis familiaris)
Mammalia -- 36
  • 84 (a)
OneToMany
-- 36
  • 81 (a)
OneToMany
MKNK1 35
  • 90.61 (n)
  • 93.69 (a)
mouse
(Mus musculus)
Mammalia Mknk1 16
Mknk1 35
  • 88.02 (n)
  • 93.89 (a)
Mknk1 36
  • 93 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia MKNK1 36
  • 84 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia MKNK1 36
  • 78 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Mknk1 35
  • 88.64 (n)
  • 94.53 (a)
chicken
(Gallus gallus)
Aves MKNK1 36
  • 83 (a)
OneToOne
MKNK1 35
  • 75.96 (n)
  • 86.06 (a)
lizard
(Anolis carolinensis)
Reptilia MKNK1 36
  • 75 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia mnk1 35
tropical clawed frog
(Silurana tropicalis)
Amphibia mknk1 35
  • 73.96 (n)
  • 82.84 (a)
Str.15197 35
zebrafish
(Danio rerio)
Actinopterygii mknk1 36
  • 68 (a)
OneToOne
mknk1 35
  • 72.12 (n)
  • 78.34 (a)
fruit fly
(Drosophila melanogaster)
Insecta Lk6 37
  • 47 (a)
Lk6 35
  • 60.32 (n)
  • 59.52 (a)
Lk6 36
  • 20 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea mnk-1 36
  • 27 (a)
OneToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes RCK1 36
  • 23 (a)
ManyToMany
RCK2 36
  • 19 (a)
ManyToMany
sea squirt
(Ciona savignyi)
Ascidiacea CSA.11342 36
  • 58 (a)
OneToMany
Species with no ortholog for MKNK1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for MKNK1 Gene

ENSEMBL:
Gene Tree for MKNK1 (if available)
TreeFam:
Gene Tree for MKNK1 (if available)

Paralogs for MKNK1 Gene

Paralogs for MKNK1 Gene

genes like me logo Genes that share paralogs with MKNK1: view

Variants for MKNK1 Gene

Sequence variations from dbSNP and Humsavar for MKNK1 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
rs56351860 - 46,580,619(+) CAGCT(G/T)GTACA intron-variant, nc-transcript-variant, reference, missense, utr-variant-5-prime
rs56408722 - 46,572,084(+) GTCAA(C/G)GGCAG nc-transcript-variant, reference, missense
VAR_040803 -
VAR_040804 -
rs764803 -- 46,590,555(-) CTTAC(A/G)AGCTA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for MKNK1 Gene

Variant ID Type Subtype PubMed ID
nsv755 CNV Insertion 18451855

Variation tolerance for MKNK1 Gene

Residual Variation Intolerance Score: 41.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.73; 32.81% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for MKNK1 Gene

HapMap Linkage Disequilibrium report
MKNK1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MKNK1 Gene

Disorders for MKNK1 Gene

Relevant External Links for MKNK1

Genetic Association Database (GAD)
MKNK1
Human Genome Epidemiology (HuGE) Navigator
MKNK1
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
MKNK1

No disorders were found for MKNK1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MKNK1 Gene

Publications for MKNK1 Gene

  1. MNK1, a new MAP kinase-activated protein kinase, isolated by a novel expression screening method for identifying protein kinase substrates. (PMID: 9155018) Fukunaga R. … Hunter T. (EMBO J. 1997) 2 3 4 67
  2. The C-terminal domain of Mnk1a plays a dual role in tightly regulating its activity. (PMID: 19650764) Goto S. … Proud C.G. (Biochem. J. 2009) 3 23
  3. Regulation of sprouty stability by Mnk1-dependent phosphorylation. (PMID: 16479008) DaSilva J. … Bar-Sagi D. (Mol. Cell. Biol. 2006) 3 23
  4. Elevated inorganic phosphate stimulates Akt-ERK1/2-Mnk1 signaling in human lung cells. (PMID: 16763222) Chang S.H. … Cho M.H. (Am. J. Respir. Cell Mol. Biol. 2006) 3 23
  5. Features of the catalytic domains and C termini of the MAPK signal-integrating kinases Mnk1 and Mnk2 determine their differing activities and regulatory properties. (PMID: 16162500) Parra J.L. … Proud C.G. (J. Biol. Chem. 2005) 3 23

Products for MKNK1 Gene

Sources for MKNK1 Gene

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