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Aliases for MKNK1 Gene

Aliases for MKNK1 Gene

  • MAP Kinase Interacting Serine/Threonine Kinase 1 2 3
  • MNK1 3 4 6
  • MAP Kinase Signal-Integrating Kinase 1 3 4
  • MAPK Signal-Integrating Kinase 1 3 4
  • EC 2.7.11.1 4 64
  • MAP Kinase-Interacting Serine/Threonine-Protein Kinase 1 3
  • EC 2.7.11 64

External Ids for MKNK1 Gene

Summaries for MKNK1 Gene

Entrez Gene Summary for MKNK1 Gene

  • This gene encodes a Ser/Thr protein kinase that interacts with, and is activated by ERK1 and p38 mitogen-activated protein kinases, and thus may play a role in the response to environmental stress and cytokines. This kinase may also regulate transcription by phosphorylating eIF4E via interaction with the C-terminal region of eIF4G. Alternatively spliced transcript variants have been noted for this gene. [provided by RefSeq, Jan 2012]

GeneCards Summary for MKNK1 Gene

MKNK1 (MAP Kinase Interacting Serine/Threonine Kinase 1) is a Protein Coding gene. Among its related pathways are Signaling by FGFR and Signaling by FGFR. GO annotations related to this gene include protein serine/threonine kinase activity. An important paralog of this gene is MKNK2.

UniProtKB/Swiss-Prot for MKNK1 Gene

  • May play a role in the response to environmental stress and cytokines. Appears to regulate translation by phosphorylating EIF4E, thus increasing the affinity of this protein for the 7-methylguanosine-containing mRNA cap.

Gene Wiki entry for MKNK1 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MKNK1 Gene

Genomics for MKNK1 Gene

Genomic Location for MKNK1 Gene

Start:
46,557,407 bp from pter
End:
46,616,843 bp from pter
Size:
59,437 bases
Orientation:
Minus strand

Genomic View for MKNK1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for MKNK1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MKNK1 Gene

Regulatory Elements for MKNK1 Gene

Proteins for MKNK1 Gene

  • Protein details for MKNK1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9BUB5-MKNK1_HUMAN
    Recommended name:
    MAP kinase-interacting serine/threonine-protein kinase 1
    Protein Accession:
    Q9BUB5
    Secondary Accessions:
    • D3DQ20
    • D3DQ21
    • O00312
    • Q5TC06
    • Q5TC07
    • Q6V0N6

    Protein attributes for MKNK1 Gene

    Size:
    465 amino acids
    Molecular mass:
    51342 Da
    Cofactor:
    Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
    Quaternary structure:
    • Interacts with the C-terminal regions of EIF4G1 and EIF4G2. Also binds to dephosphorylated ERK1 and ERK2, and to the p38 kinases.

    Three dimensional structures from OCA and Proteopedia for MKNK1 Gene

    Alternative splice isoforms for MKNK1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for MKNK1 Gene

Proteomics data for MKNK1 Gene at MOPED

Post-translational modifications for MKNK1 Gene

  • Dual phosphorylation of Thr-250 and Thr-255 activates the kinase. Phosphorylation of Thr-385 activates the kinase. MAPK3/ERK1 is one of the kinases which activate MKNK1/MNK1. Phosphorylation by PAK2 leads to a reduced phosphorylation of EIF4G1.
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Domains for MKNK1 Gene

Gene Families for MKNK1 Gene

UniProtKB/Swiss-Prot:

MKNK1_HUMAN
Domain:
  • Contains 1 protein kinase domain.:
    • Q9BUB5
Family:
  • Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family.:
    • Q9BUB5
genes like me logo Genes that share domains with MKNK1: view

Function for MKNK1 Gene

Molecular function for MKNK1 Gene

UniProtKB/Swiss-Prot CatalyticActivity: ATP + a protein = ADP + a phosphoprotein.
UniProtKB/Swiss-Prot EnzymeRegulation: Phosphorylated and activated by the p38 kinases and kinases in the Erk pathway.
UniProtKB/Swiss-Prot Function: May play a role in the response to environmental stress and cytokines. Appears to regulate translation by phosphorylating EIF4E, thus increasing the affinity of this protein for the 7-methylguanosine-containing mRNA cap.

Enzyme Numbers (IUBMB) for MKNK1 Gene

Gene Ontology (GO) - Molecular Function for MKNK1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004672 protein kinase activity --
GO:0004674 protein serine/threonine kinase activity IDA 17130135
GO:0004683 calmodulin-dependent protein kinase activity IBA --
GO:0004713 protein tyrosine kinase activity --
GO:0005515 protein binding IPI 20936779
genes like me logo Genes that share ontologies with MKNK1: view
genes like me logo Genes that share phenotypes with MKNK1: view

Animal Models for MKNK1 Gene

MGI Knock Outs for MKNK1:

miRNA for MKNK1 Gene

miRTarBase miRNAs that target MKNK1

No data available for Transcription Factor Targeting and HOMER Transcription for MKNK1 Gene

Localization for MKNK1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for MKNK1 Gene

Isoform 2: Cytoplasm.
Isoform 3: Cytoplasm. Nucleus.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for MKNK1 Gene COMPARTMENTS Subcellular localization image for MKNK1 gene
Compartment Confidence
nucleus 5
cytosol 4

Gene Ontology (GO) - Cellular Components for MKNK1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IBA --
GO:0005737 cytoplasm IBA --
GO:0005829 cytosol TAS --
GO:0016020 membrane --
genes like me logo Genes that share ontologies with MKNK1: view

Pathways for MKNK1 Gene

genes like me logo Genes that share pathways with MKNK1: view

Pathways by source for MKNK1 Gene

Gene Ontology (GO) - Biological Process for MKNK1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006417 regulation of translation --
GO:0006446 regulation of translational initiation IEA --
GO:0006468 protein phosphorylation IDA 9155018
GO:0008152 metabolic process --
GO:0008543 fibroblast growth factor receptor signaling pathway TAS --
genes like me logo Genes that share ontologies with MKNK1: view

Compounds for MKNK1 Gene

(3) Tocris Compounds for MKNK1 Gene

Compound Action Cas Number
HI TOPK 032 Selective T-LAK-cell-originated protein kinase (TOPK) inhibitor [487020-03-1]
NQDI 1 Inhibitor of apoptosis signal-regulating kinase 1 (ASK1) [175026-96-7]
PF 3644022 Potent MK2 inhibitor [1276121-88-0]

(3) HMDB Compounds for MKNK1 Gene

Compound Synonyms Cas Number PubMed IDs
Adenosine triphosphate
  • 5'-(tetrahydrogen triphosphate) Adenosine
56-65-5
ADP
  • adenosindiphosphorsaeure
58-64-0
Magnesium
  • Magnesium
7439-95-4

(5) Novoseek inferred chemical compound relationships for MKNK1 Gene

Compound -log(P) Hits PubMed IDs
anisomycin 66.5 1
sb 203580 51.4 2
serine 13.8 2
alanine 5.43 1
h2o2 4.63 2
genes like me logo Genes that share compounds with MKNK1: view

Transcripts for MKNK1 Gene

Unigene Clusters for MKNK1 Gene

MAP kinase interacting serine/threonine kinase 1:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for MKNK1 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3a · 3b ^ 4 ^ 5a · 5b ^ 6 ^ 7 ^ 8a · 8b ^ 9a · 9b ^ 10 ^ 11a · 11b ^ 12 ^ 13 ^ 14 ^ 15a · 15b ^ 16a · 16b ^ 17a ·
SP1: - - - - - - - - -
SP2: - - - - - - - - - - -
SP3: - - - - - - - - - -
SP4: - - - - - - - -
SP5: - - - - - - - - - - - - -
SP6: - - -
SP7: - -
SP8: - -
SP9: -
SP10: - - - -
SP11: - - - -
SP12: -
SP13:

ExUns: 17b ^ 18 ^ 19a · 19b · 19c
SP1:
SP2:
SP3: -
SP4:
SP5: -
SP6: -
SP7:
SP8:
SP9:
SP10:
SP11:
SP12:
SP13:

Relevant External Links for MKNK1 Gene

GeneLoc Exon Structure for
MKNK1
ECgene alternative splicing isoforms for
MKNK1

Expression for MKNK1 Gene

mRNA expression in normal human tissues for MKNK1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for MKNK1 Gene

This gene is overexpressed in Whole Blood (11.0) and Pancreas (4.4).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for MKNK1 Gene

SOURCE GeneReport for Unigene cluster for MKNK1 Gene Hs.371594

mRNA Expression by UniProt/SwissProt for MKNK1 Gene

Q9BUB5-MKNK1_HUMAN
Tissue specificity: Ubiquitous.
genes like me logo Genes that share expressions with MKNK1: view

Orthologs for MKNK1 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for MKNK1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia MKNK1 36
  • 99.26 (n)
  • 99.34 (a)
cow
(Bos Taurus)
Mammalia MKNK1 36
  • 91.44 (n)
  • 93.58 (a)
MKNK1 37
  • 91 (a)
OneToOne
dog
(Canis familiaris)
Mammalia -- 37
  • 84 (a)
OneToMany
-- 37
  • 81 (a)
OneToMany
MKNK1 36
  • 90.61 (n)
  • 93.69 (a)
mouse
(Mus musculus)
Mammalia Mknk1 36
  • 88.02 (n)
  • 93.89 (a)
Mknk1 16
Mknk1 37
  • 93 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia MKNK1 37
  • 84 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia MKNK1 37
  • 78 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Mknk1 36
  • 88.64 (n)
  • 94.53 (a)
chicken
(Gallus gallus)
Aves MKNK1 36
  • 75.96 (n)
  • 86.06 (a)
MKNK1 37
  • 83 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia MKNK1 37
  • 75 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia mnk1 36
tropical clawed frog
(Silurana tropicalis)
Amphibia mknk1 36
  • 73.96 (n)
  • 82.84 (a)
Str.15197 36
zebrafish
(Danio rerio)
Actinopterygii mknk1 36
  • 72.12 (n)
  • 78.34 (a)
mknk1 37
  • 68 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta Lk6 36
  • 60.32 (n)
  • 59.52 (a)
Lk6 37
  • 20 (a)
OneToMany
Lk6 38
  • 47 (a)
worm
(Caenorhabditis elegans)
Secernentea mnk-1 37
  • 27 (a)
OneToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes RCK1 37
  • 23 (a)
ManyToMany
RCK2 37
  • 19 (a)
ManyToMany
sea squirt
(Ciona savignyi)
Ascidiacea CSA.11342 37
  • 58 (a)
OneToMany
Species with no ortholog for MKNK1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for MKNK1 Gene

ENSEMBL:
Gene Tree for MKNK1 (if available)
TreeFam:
Gene Tree for MKNK1 (if available)

Paralogs for MKNK1 Gene

genes like me logo Genes that share paralogs with MKNK1: view

Variants for MKNK1 Gene

Sequence variations from dbSNP and Humsavar for MKNK1 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type MAF
rs946321 -- 46,579,683(-) AGCCT(C/G)AGCAT intron-variant
rs1258018 -- 46,602,854(-) TACTT(A/G)GTTCC intron-variant
rs1258019 -- 46,602,802(-) ACACT(A/G)CTCGG intron-variant
rs1258020 -- 46,601,908(-) atcat(A/T)gtctg intron-variant
rs1258027 -- 46,577,374(-) cctcc(C/T)gagta intron-variant

Structural Variations from Database of Genomic Variants (DGV) for MKNK1 Gene

Variant ID Type Subtype PubMed ID
nsv755 CNV Insertion 18451855

Relevant External Links for MKNK1 Gene

HapMap Linkage Disequilibrium report
MKNK1

Disorders for MKNK1 Gene

(2) Novoseek inferred disease relationships for MKNK1 Gene

Disease -log(P) Hits PubMed IDs
shock 9.56 2
cancer 0 2

Relevant External Links for MKNK1

Genetic Association Database (GAD)
MKNK1
Human Genome Epidemiology (HuGE) Navigator
MKNK1
genes like me logo Genes that share disorders with MKNK1: view

No data available for UniProtKB/Swiss-Prot for MKNK1 Gene

Publications for MKNK1 Gene

  1. Human eukaryotic translation initiation factor 4G (eIF4G) recruits mnk1 to phosphorylate eIF4E. (PMID: 9878069) Pyronnet S. … Sonenberg N. (EMBO J. 1999) 3 4 23
  2. Phosphorylation of Mnk1 by caspase-activated Pak2/gamma-PAK inhibits phosphorylation and interaction of eIF4G with Mnk. (PMID: 15234964) Orton K.C. … Traugh J.A. (J. Biol. Chem. 2004) 3 4 23
  3. MNK1, a new MAP kinase-activated protein kinase, isolated by a novel expression screening method for identifying protein kinase substrates. (PMID: 9155018) Fukunaga R. … Hunter T. (EMBO J. 1997) 2 3 4
  4. The C-terminal domain of Mnk1a plays a dual role in tightly regulating its activity. (PMID: 19650764) Goto S. … Proud C.G. (Biochem. J. 2009) 3 23
  5. Regulation of sprouty stability by Mnk1-dependent phosphorylation. (PMID: 16479008) DaSilva J. … Bar-Sagi D. (Mol. Cell. Biol. 2006) 3 23

Products for MKNK1 Gene

  • Addgene plasmids for MKNK1

Sources for MKNK1 Gene

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