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MKL2 Gene

protein-coding   GIFtS: 56
GCID: GC16P014072

MKL/Myocardin-Like 2

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
MKL/Myocardin-Like 21 2     MRTF-B2 3
MRTFB2 3 5     NPD0012
Megakaryoblastic Leukemia 22 3     MKL/Myocardin-Like Protein 22
Myocardin-Related Transcription Factor B2 3     KIAA12433

External Ids:    HGNC: 298191   Entrez Gene: 574962   Ensembl: ENSG000001862607   OMIM: 6094635   UniProtKB: Q9ULH73   

Export aliases for MKL2 gene to outside databases


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for MKL2 Gene:
MKL2 (MKL/myocardin-like 2) is a protein-coding gene. Diseases associated with MKL2 include chondroid lipoma, and lipoma. GO annotations related to this gene include sequence-specific DNA binding transcription factor activity and nucleic acid binding. An important paralog of this gene is MYOCD.

UniProtKB/Swiss-Prot: MKL2_HUMAN, Q9ULH7
Function: Acts as a transcriptional coactivator of serum response factor (SRF). Required for skeletal myogenic
differentiation

Gene Wiki entry for MKL2 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000016.10  NT_010393.17  NC_018927.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the MKL2 gene promoter:
         TBP   E2F-4   E2F-3a   E2F-5   AML1a   E2F-2   Evi-1   E47   E2F   E2F-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): MKL2 promoter sequence
   Search Chromatin IP Primers for MKL2

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat MKL2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 16p13.12   Ensembl cytogenetic band:  16p13.12   HGNC cytogenetic band: 16p13.12

MKL2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
MKL2 gene location

GeneLoc information about chromosome 16         GeneLoc Exon Structure

GeneLoc location for GC16P014072:  view genomic region     (about GC identifiers)

Start:
14,165,178 bp from pter      End:
14,360,630 bp from pter
Size:
195,453 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: MKL2_HUMAN, Q9ULH7 (See protein sequence)
Recommended Name: MKL/myocardin-like protein 2  
Size: 1088 amino acids; 118127 Da
Subunit: Interacts with MKL1 and SRF
Secondary accessions: A6ND53 Q68CT1 Q6UB16 Q86WW2 Q8N226
Alternative splicing: 4 isoforms:  Q9ULH7-1   Q9ULH7-2   Q9ULH7-3   Q9ULH7-4   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for MKL2: NX_Q9ULH7

Explore proteomics data for MKL2 at MOPED

Post-translational modifications: 

  • O-glycosylated (By similarity)1
  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See MKL2 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_054767.3  
    ENSEMBL proteins: 
     ENSP00000458340   ENSP00000459626   ENSP00000459205   ENSP00000460848   ENSP00000459879  
     ENSP00000460589   ENSP00000459518   ENSP00000339086   ENSP00000345841  

    MKL2 Human Recombinant Protein Products:

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    2 InterPro protein domains:
     IPR003034 SAP_dom
     IPR004018 RPEL_repeat

    Graphical View of Domain Structure for InterPro Entry Q9ULH7

    ProtoNet protein and cluster: Q9ULH7

    1 Blocks protein domain: IPB003034 DNA-binding SAP

    UniProtKB/Swiss-Prot: MKL2_HUMAN, Q9ULH7
    Domain: The N-terminal region is required for nuclear localization and the C-terminal region mediates
    transcriptional activity (By similarity)
    Similarity: Contains 3 RPEL repeats
    Similarity: Contains 1 SAP domain


    MKL2 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: MKL2_HUMAN, Q9ULH7
    Function: Acts as a transcriptional coactivator of serum response factor (SRF). Required for skeletal myogenic
    differentiation

         Gene Ontology (GO): 5 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003676nucleic acid binding IEA--
    GO:0003700sequence-specific DNA binding transcription factor activity IEA--
    GO:0003713transcription coactivator activity IDA14565952
    GO:0003779actin binding IEA--
    GO:0005515protein binding IPI12397177
         
    MKL2 for ontologies           About GeneDecksing


    Phenotypes:
         13 MGI mutant phenotypes (inferred from 5 alleles(MGI details for Mkl2):
     cardiovascular system  cellular  craniofacial  embryogenesis  growth/size/body 
     homeostasis/metabolism  liver/biliary system  mortality/aging  muscle  nervous system 
     no phenotypic analysis  normal  respiratory system 

    MKL2 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-outs for MKL2: Mkl2tm1.1Msp Mkl2tm1Eno

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for MKL2
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       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for MKL2
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for MKL2

    miRNA
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    miRTarBase miRNAs that target MKL2:
    hsa-mir-192-5p (MIRT026812), hsa-mir-215-5p (MIRT024852), hsa-mir-29c-3p (MIRT020358)

    Block miRNA regulation of human, mouse, rat MKL2 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate MKL2 (see all 141):
    hsa-miR-520f hsa-miR-106a hsa-miR-3653 hsa-miR-519a hsa-miR-877* hsa-miR-409-5p hsa-miR-200b hsa-miR-92b
    Browse SwitchGear 3'UTR luciferase reporter plasmids
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MKL2

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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MKL2


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    MKL2_HUMAN, Q9ULH7: Nucleus (By similarity)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus4
    cytosol2
    cytoskeleton1

    Gene Ontology (GO): 2 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IC14565952
    GO:0005737cytoplasm IEA--

    MKL2 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for MKL2
    Interactions:

        GeneGlobe Interaction Network for MKL2

    STRING Interaction Network Preview (showing 5 interactants - click image to see 13)

    Selected Interacting proteins for MKL2 (Q9ULH71, 2, 3 ENSP000003390864) via UniProtKB, MINT, STRING, and/or I2D (see all 16)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    SMAD1Q157972, 3MINT-62006 I2D: score=2 
    SMAD7O151052, 3MINT-61820 I2D: score=2 
    SRFP118311, 3, ENSP000002653544EBI-493007,EBI-493034 I2D: score=3 STRING: ENSP00000265354
    MKL1Q969V63, ENSP000003478474I2D: score=3 STRING: ENSP00000347847
    KDM3AQ9Y4C13, ENSP000003236594I2D: score=1 STRING: ENSP00000323659
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 15):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001701in utero embryonic development IEA--
    GO:0001889liver development IEA--
    GO:0003007heart morphogenesis IEA--
    GO:0006351transcription, DNA-templated IEA--
    GO:0007507heart development ----

    MKL2 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for MKL2



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for MKL2 gene: 
    NM_014048.3  

    Unigene Cluster for MKL2:

    MKL/myocardin-like 2
    Hs.49143  [show with all ESTs]
    Unigene Representative Sequence: NM_014048
    14 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000574998 ENST00000572400 ENST00000571589(uc002dcg.3 uc010uza.2)
    ENST00000574045 ENST00000575537 ENST00000575833 ENST00000573434 ENST00000575768
    ENST00000572567(uc002dch.3) ENST00000573051(uc010uzb.2) ENST00000572588(uc002dcj.3)
    ENST00000571770 ENST00000318282 ENST00000341243
    miRNA
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    Block miRNA regulation of human, mouse, rat MKL2 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate MKL2 (see all 141):
    hsa-miR-520f hsa-miR-106a hsa-miR-3653 hsa-miR-519a hsa-miR-877* hsa-miR-409-5p hsa-miR-200b hsa-miR-92b
    Browse SwitchGear 3'UTR luciferase reporter plasmids
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    Predesigned siRNA for gene silencing in human, mouse, rat MKL2
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    OriGene ORF clones in mouse, rat for MKL2
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: MKL2 (NM_014048)
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MKL2
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    OriGene qSTAR qPCR primer pairs in human, mouse for MKL2
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat MKL2
      QuantiTect SYBR Green Assays in human, mouse, rat MKL2
      QuantiFast Probe-based Assays in human, mouse, rat MKL2

    Additional mRNA sequence: 

    AB033069.2 AF078853.1 AK056385.1 AK057216.1 AK093577.1 AK126948.1 AK127530.1 AK294765.1 
    AY374297.1 BC006977.1 BC016293.1 BC020644.1 BC030510.1 BC034934.1 BC038834.1 BC047761.1 
    BC050541.1 BC067270.1 BC073950.1 BC107868.1 BC127941.1 BC136260.1 BC171750.1 BX641041.1 
    CR749797.1 

    16 DOTS entries:

    DT.100684870  DT.452907  DT.95084103  DT.40261682  DT.101969937  DT.92070705  DT.97845854  DT.92070706 
    DT.100684680  DT.100893299  DT.101974739  DT.316083  DT.75172116  DT.97769250  DT.97770240  DT.95325687 

    1 AceView cDNA sequence:

    CB993850 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for MKL2 (see all 8)    About this scheme

    ExUns: 1 ^ 2a · 2b ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18 ^ 19 ^ 20 ^ 21 ^ 22a · 22b ^ 23a · 23b
    SP1:              -     -     -     -     -                                               -                 -                                                   
    SP2:                                                                                                                                                            
    SP3:                                                                                      -                                                                     
    SP4:                                      -                                                                                                                     
    SP5:                                                                                                                                                            


    ECgene alternative splicing isoforms for MKL2

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    MKL2 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TACTGTACAT
    MKL2 Expression
    About this image

    MKL2 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    MKL2 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.49143
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MKL2

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for MKL2 gene from Selected species (see all 13)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Mkl21 , 5 MKL/myocardin-like 21, 5 83.04(n)1
    84.27(a)1
      16 (9.24 cM)5
    2397191  NM_001122667.21  NP_001116139.11 
     132564815 
    chicken
    (Gallus gallus)
    Aves MKL21 MKL/myocardin-like 2 72.44(n)
    73.72(a)
      416421  XM_004945070.1  XP_004945127.1 
    lizard
    (Anolis carolinensis)
    Reptilia MKL26
    MKL/myocardin-like 2
    59(a)
    1 ↔ 1
    GL343649.1(302174-332378)
    African clawed frog
    (Xenopus laevis)
    Amphibia mrtf-b-A2 myocardin-related transcription factor B 75.54(n)    AF532600.1 
    zebrafish
    (Danio rerio)
    Actinopterygii mkl2a1 MKL/myocardin-like 2a 66.83(n)
    70.53(a)
      793956  XM_001333803.3  XP_001333839.2 
    fruit fly
    (Drosophila melanogaster)
    Insecta Mrtf6
    Myocardin-related transcription factor
    15(a)
    1 → many
    3L(2717615-2766480)


    ENSEMBL Gene Tree for MKL2 (if available)
    TreeFam Gene Tree for MKL2 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for MKL2 gene
    MYOCD2  ENSG000002734522  MKL12  
    2 SIMAP similar genes for MKL2 using alignment to 8 protein entries:     MKL2_HUMAN (see all proteins):
    MKL1    MYOCD

    MKL2 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for MKL2 (see all 3736)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 16 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs799301151,2
    F--14163243(+) AACTGC/TGACTG 1 -- us2k11Minor allele frequency- T:0.03WA 118
    rs1504015671,2
    --14163297(+) ACATCA/GTAGGA 1 -- us2k10--------
    rs1869267181,2
    --14163369(+) ACAGGC/GTCTCA 1 -- us2k10--------
    rs1382402061,2
    --14163527(+) AGAGAC/TGGGGT 1 -- us2k10--------
    rs1428388701,2
    --14163529(+) AGACGG/TGGTCT 1 -- us2k10--------
    rs133334741,2
    C,F,H--14163635(+) tgcccA/Ggccta 1 -- us2k113Minor allele frequency- G:0.15NS EA NA CSA WA 1312
    rs1460086681,2
    --14163705(+) GAGGGC/GTAAAT 1 -- us2k10--------
    rs1399004651,2
    --14163822(+) AGGTTA/GAAACA 1 -- us2k10--------
    rs752055021,2
    C,F--14163927(+) ATTGAT/CGTGAT 1 -- us2k12Minor allele frequency- C:0.15CSA WA 120
    rs1150144411,2
    F--14163949(+) CTGGGT/GAAGCC 1 -- us2k11Minor allele frequency- G:0.02WA 118

    HapMap Linkage Disequilibrium report for MKL2 (14165178 - 14360630 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 5 variations for MKL2:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2714006CNV Deletion23290073
    esv275519CNV Loss21479260
    nsv457423CNV Gain19166990
    nsv520888CNV Gain19592680
    esv274988CNV Gain+Loss21479260

    Human Gene Mutation Database (HGMD): MKL2
    Site Specific Mutation Identification with PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 609463    OMIM disorders: --

    4 diseases for MKL2:    
    About MalaCards
    chondroid lipoma    lipoma    leukemia    autism spectrum disorder

    1 disease from the University of Copenhagen DISEASES database for MKL2:
    Lipoma

    MKL2 for disorders           About GeneDecksing

    Genetic Association Database (GAD): MKL2
    Human Genome Epidemiology (HuGE) Navigator: MKL2 (2 documents)

    Export disorders for MKL2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for MKL2 gene, integrated from 10 sources (see all 36):
    (articles sorted by number of sources associating them with MKL2)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Prediction of the coding sequences of unidentified human genes. XV. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PubMed id 10574462)1, 2, 3 Nagase T.... Ohara O. (DNA Res. 1999)
    2. Megakaryoblastic leukemia-1/2, a transcriptional co-activator of serum response factor, is required for skeletal myogenic differentiation. (PubMed id 14565952)1, 2, 9 Selvaraj A. and Prywes R. (J. Biol. Chem. 2003)
    3. Thirty new loci for age at menarche identified by a meta-analysis of genome-wide association studies. (PubMed id 21102462)1, 4 Elks C.E....Murray A. (Nat. Genet. 2010)
    4. Linkage and candidate gene studies of autism spectrum disorders in European populations. (PubMed id 20442744)1, 4 Holt R....Monaco A.P. (Eur. J. Hum. Genet. 2010)
    5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    6. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    7. Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones. (PubMed id 12168954)1, 2 Nakajima D.... Nagase T. (DNA Res. 2002)
    8. Control of phenotypic plasticity of smooth muscle cells by bone morphogenetic protein signaling through the myocardin-related transcription factors. (PubMed id 17947237)1, 9 Lagna G....Hata A. (J. Biol. Chem. 2007)
    9. Megakaryoblastic leukemia 1, a potent transcriptional coactivator for serum response factor (SRF), is required for serum induction of SRF target genes. (PubMed id 12944485)1, 9 Cen B....Prywes R. (Mol. Cell. Biol. 2003)
    10. Depletion of the transcriptional coactivators megakaryoblastic leukaemia 1 and 2 abolishes hepatocellular carcinoma xenograft growth by inducing oncogene-induced senescence. (PubMed id 23853104)1 Hampl V....Muehlich S. (EMBO Mol Med 2013)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 57496 HGNC: 29819 AceView: MKL2.1 Ensembl:ENSG00000186260 euGenes: HUgn57496
    ECgene: MKL2 H-InvDB: MKL2

    (According to HUGE)
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    HUGE: KIAA1243

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for MKL2 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for MKL2 gene:
    Search GeneIP for patents involving MKL2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014

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