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Aliases for MKL2 Gene

Aliases for MKL2 Gene

  • MKL/Myocardin-Like 2 2 3
  • MRTFB 3 4 6
  • Myocardin-Related Transcription Factor B 3 4
  • Megakaryoblastic Leukemia 2 3 4
  • MRTF-B 3 4
  • MKL/Myocardin-Like Protein 2 3
  • KIAA1243 4
  • NPD001 3

External Ids for MKL2 Gene

Summaries for MKL2 Gene

GeneCards Summary for MKL2 Gene

MKL2 (MKL/Myocardin-Like 2) is a Protein Coding gene. Diseases associated with MKL2 include chondroid lipoma. GO annotations related to this gene include sequence-specific DNA binding transcription factor activity and nucleic acid binding. An important paralog of this gene is MKL1.

UniProtKB/Swiss-Prot for MKL2 Gene

  • Acts as a transcriptional coactivator of serum response factor (SRF). Required for skeletal myogenic differentiation.

Gene Wiki entry for MKL2 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MKL2 Gene

Genomics for MKL2 Gene

Regulatory Elements for MKL2 Gene

Genomic Location for MKL2 Gene

14,071,321 bp from pter
14,266,776 bp from pter
195,456 bases
Plus strand

Genomic View for MKL2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for MKL2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MKL2 Gene

Proteins for MKL2 Gene

  • Protein details for MKL2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    MKL/myocardin-like protein 2
    Protein Accession:
    Secondary Accessions:
    • A6ND53
    • B4DGT8
    • Q68CT1
    • Q6UB16
    • Q86WW2
    • Q8N226

    Protein attributes for MKL2 Gene

    1088 amino acids
    Molecular mass:
    118127 Da
    Quaternary structure:
    • Interacts with MKL1 and SRF.

    Alternative splice isoforms for MKL2 Gene


neXtProt entry for MKL2 Gene

Proteomics data for MKL2 Gene at MOPED

Post-translational modifications for MKL2 Gene

No data available for DME Specific Peptides for MKL2 Gene

Domains for MKL2 Gene

Protein Domains for MKL2 Gene


Graphical View of Domain Structure for InterPro Entry



  • Q9ULH7
  • The N-terminal region is required for nuclear localization and the C-terminal region mediates transcriptional activity.
  • Contains 1 SAP domain.
  • Contains 3 RPEL repeats.
genes like me logo Genes that share domains with MKL2: view

No data available for Gene Families for MKL2 Gene

Function for MKL2 Gene

Molecular function for MKL2 Gene

UniProtKB/Swiss-Prot Function: Acts as a transcriptional coactivator of serum response factor (SRF). Required for skeletal myogenic differentiation.

Gene Ontology (GO) - Molecular Function for MKL2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003676 nucleic acid binding --
GO:0003700 sequence-specific DNA binding transcription factor activity IEA --
GO:0003713 transcription coactivator activity IDA 14565952
GO:0003779 actin binding IEA --
GO:0005515 protein binding IPI 12397177
genes like me logo Genes that share ontologies with MKL2: view
genes like me logo Genes that share phenotypes with MKL2: view

Animal Models for MKL2 Gene

MGI Knock Outs for MKL2:

miRNA for MKL2 Gene

miRTarBase miRNAs that target MKL2

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targeting and HOMER Transcription for MKL2 Gene

Localization for MKL2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for MKL2 Gene

Subcellular locations from

Jensen Localization Image for MKL2 Gene COMPARTMENTS Subcellular localization image for MKL2 gene
Compartment Confidence
nucleus 4
cytosol 2
cytoskeleton 1

Gene Ontology (GO) - Cellular Components for MKL2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IC 14565952
GO:0005737 cytoplasm IEA --
genes like me logo Genes that share ontologies with MKL2: view

Pathways for MKL2 Gene

SuperPathways for MKL2 Gene

No Data Available

Gene Ontology (GO) - Biological Process for MKL2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001701 in utero embryonic development IEA --
GO:0001889 liver development IEA --
GO:0003007 heart morphogenesis IEA --
GO:0006351 transcription, DNA-templated IEA --
GO:0007507 heart development --
genes like me logo Genes that share ontologies with MKL2: view

No data available for Pathways by source for MKL2 Gene

Transcripts for MKL2 Gene

mRNA/cDNA for MKL2 Gene

(25) Additional mRNA sequences :
(12) REFSEQ mRNAs :
(1) Selected AceView cDNA sequences:
(13) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for MKL2 Gene

MKL/myocardin-like 2:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for MKL2 Gene

ExUns: 1 ^ 2a · 2b ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18 ^ 19 ^ 20 ^ 21 ^ 22a · 22b ^ 23a · 23b
SP1: - - - - - - -
SP3: -
SP4: -
SP6: -

Relevant External Links for MKL2 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for MKL2 Gene

mRNA expression in normal human tissues for MKL2 Gene

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for MKL2 Gene

SOURCE GeneReport for Unigene cluster for MKL2 Gene Hs.49143

genes like me logo Genes that share expressions with MKL2: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for MKL2 Gene

Orthologs for MKL2 Gene

This gene was present in the common ancestor of animals.

Orthologs for MKL2 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia MKL2 35
  • 99.56 (n)
  • 99.9 (a)
MKL2 36
  • 93 (a)
(Bos Taurus)
Mammalia MKL2 35
  • 85.85 (n)
  • 87.51 (a)
MKL2 36
  • 87 (a)
(Canis familiaris)
Mammalia MKL2 35
  • 88.23 (n)
  • 90.59 (a)
MKL2 36
  • 84 (a)
(Mus musculus)
Mammalia Mkl2 35
  • 83.04 (n)
  • 84.27 (a)
Mkl2 16
Mkl2 36
  • 80 (a)
(Monodelphis domestica)
Mammalia MKL2 36
  • 73 (a)
(Ornithorhynchus anatinus)
Mammalia MKL2 36
  • 75 (a)
(Gallus gallus)
Aves MKL2 35
  • 72.44 (n)
  • 73.72 (a)
MKL2 36
  • 67 (a)
(Anolis carolinensis)
Reptilia MKL2 36
  • 59 (a)
African clawed frog
(Xenopus laevis)
Amphibia mrtf-b-A 35
tropical clawed frog
(Silurana tropicalis)
Amphibia mkl2 35
  • 66.56 (n)
  • 65.44 (a)
(Danio rerio)
Actinopterygii MKL2 (1 of 3) 36
  • 47 (a)
mkl2a 35
  • 66.83 (n)
  • 70.53 (a)
mkl2a 36
  • 45 (a)
mkl2b 36
  • 47 (a)
fruit fly
(Drosophila melanogaster)
Insecta Mrtf 36
  • 15 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.5092 36
  • 41 (a)
Species with no ortholog for MKL2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for MKL2 Gene

Gene Tree for MKL2 (if available)
Gene Tree for MKL2 (if available)

Paralogs for MKL2 Gene

Paralogs for MKL2 Gene

Selected SIMAP similar genes for MKL2 Gene using alignment to 8 proteins:

genes like me logo Genes that share paralogs with MKL2: view

Variants for MKL2 Gene

Sequence variations from dbSNP and Humsavar for MKL2 Gene

SNP ID Clin Chr 16 pos Sequence Context AA Info Type MAF
rs30122 -- 14,265,376(+) AACAT(A/T)AACTG utr-variant-3-prime
rs30123 -- 14,265,348(+) CCACA(A/G)AATTA utr-variant-3-prime
rs30124 -- 14,260,177(-) CTTGT(C/T)TTCTG intron-variant
rs30125 -- 14,260,804(+) CGTGC(A/G)TAGAA intron-variant
rs30126 -- 14,261,908(+) AGAGA(C/T)GGCCG utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for MKL2 Gene

Variant ID Type Subtype PubMed ID
nsv457423 CNV Gain 19166990
esv2714006 CNV Deletion 23290073
nsv520888 CNV Gain 19592680
esv274988 CNV Gain+Loss 21479260
esv275519 CNV Loss 21479260

Relevant External Links for MKL2 Gene

HapMap Linkage Disequilibrium report
Human Gene Mutation Database (HGMD)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MKL2 Gene

Disorders for MKL2 Gene

MalaCards: The human disease database

MalaCards: The human disease database. (1) Diseases for MKL2 Gene including...

Search for MKL2 Gene in MalaCards »


  • Note=A chromosomal aberration involving C11orf95 is found in 3 chondroid lipomas. Translocation t(11;16)(q13;p13) with C11orf95 produces a C11orf95-MKL2 fusion protein (PubMed:20607705). {ECO:0000269 PubMed:20607705}.

(1) University of Copenhagen DISEASES for MKL2 Gene

Relevant External Links for MKL2

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
genes like me logo Genes that share disorders with MKL2: view

Publications for MKL2 Gene

  1. Megakaryoblastic leukemia-1/2, a transcriptional co-activator of serum response factor, is required for skeletal myogenic differentiation. (PMID: 14565952) Selvaraj A. … Prywes R. (J. Biol. Chem. 2003) 3 4 23
  2. Prediction of the coding sequences of unidentified human genes. XV. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PMID: 10574462) Nagase T. … Ohara O. (DNA Res. 1999) 2 3 4
  3. Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones. (PMID: 12168954) Nakajima D. … Nagase T. (DNA Res. 2002) 3 4
  4. Control of phenotypic plasticity of smooth muscle cells by bone morphogenetic protein signaling through the myocardin-related transcription factors. (PMID: 17947237) Lagna G. … Hata A. (J. Biol. Chem. 2007) 3 23
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4

Products for MKL2 Gene

Sources for MKL2 Gene

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