MKL1 Gene
protein-coding GIFtS: 59
GCID: GC22M040807
|
|
megakaryoblastic leukemia (translocation) 1
| |
Aliases
for MKL1 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Megakaryoblastic Leukemia (Translocation) 11 2 | | Megakaryocytic Acute Leukemia Protein2 3 | | MAL1 2 3 5 | | Myocardin-Related Transcription Factor A2 3 | | MRTF-A1 2 3 | | Basic, SAP And Coiled-Coil Domain2 | | BSAC1 2 | | MKL/Myocardin-Like Protein 12 | | KIAA14381 3 | | RNA-Binding Motif Protein 15/Megakaryoblastic Leukemia-1 Fusion Protein2 | | Megakaryoblastic Leukemia 1 Protein2 3 | | AMKL5 |
Export aliases for MKL1 gene to outside databasesPrevious GC identifers: GC22M037420 GC22M039049 GC22M039130 GC22M023769 |
Summaries
for MKL1 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for MKL1:
The protein encoded by this gene interacts with the transcription factor myocardin, a key regulator of smooth musclecell differentiation. The encoded protein is predominantly nuclear and may help transduce signals from thecytoskeleton to the nucleus. This gene is involved in a specific translocation event that creates a fusion of thisgene and the RNA-binding motif protein-15 gene. This translocation has been associated with acute megakaryocyticleukemia. (provided by RefSeq, Jul 2008)
UniProtKB/Swiss-Prot: MKL1_HUMAN, Q969V6Function: Transcriptional coactivator of serum response factor (SRF) with the potential to modulate SRF target genes.Suppresses TNF-induced cell death by inhibiting activation of caspases; its transcriptional activity is indispensablefor the antiapoptotic function. It may up-regulate antiapoptotic molecules, which in turn inhibit caspase activation(By similarity)
Gene Wiki entry for MKL1
|
Genomic Views
for MKL1 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000022.10 NC_018933.1 NT_011520.12
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the MKL1 gene promoter:
AhR SRF AML1a Egr-1 p300 SRF (504 AA) HNF-1A Arnt HSF2 HNF-1
Other transcription factors
Search SABiosciences Chromatin IP Primers for MKL1
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat MKL1 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 22q13 Ensembl cytogenetic band: 22q13.2 HGNC cytogenetic band: 22q13MKL1 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 22 GeneLoc Exon Structure GeneLoc location for GC22M040807: view genomic region
(about GC identifiers)
Start:
|
40,806,285 bp from pter |
End:
|
41,032,706 bp from pter |
Size:
|
226,422 bases |
Orientation:
|
minus strand |
|
Proteins
for MKL1 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: MKL1_HUMAN, Q969V6 (See
protein sequence)Recommended Name: MKL/myocardin-like protein 1 Size: 931 amino acids; 98919 Da
Subunit: Forms with SCAI and SRF a nuclear ternary complex which binds the CArG consensus motif (CArG box) on DNA viaSRF. Interacts with ACTB; interaction with ACTB prevents interaction with SCAI. Interacts with MKL2 (By similarity)
Subcellular location: Cytoplasm (By similarity). Nucleus (By similarity). Note=Binding to globular actin is required tomaintain cytoplasmic localization (By similarity)
Sequence caution: Sequence=AAK56920.1; Type=Erroneous initiation; Sequence=BAA92676.2; Type=Erroneous initiation;Sequence=CAC38828.1; Type=Erroneous initiation; Sequence=CAC38829.1; Type=Erroneous initiation;
2 PDB 3D structures from  and Proteopedia  for MKL1:2KVU (3D)
2KW9 (3D)
Secondary accessions: Q8TCL1 Q96SC5 Q96SC6 Q9P2B0Explore the universe of human proteins at neXtProt for MKL1: NX_Q969V6
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q969V6
MKL1 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_065882.1
ENSEMBL proteins: ENSP00000347847 ENSP00000385584 ENSP00000385835 ENSP00000385076 ENSP00000398478 ENSP00000379861
Human Recombinant Protein Products:
Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view): About this table
MKL1 for ontologies About GeneDecksing
MKL1 Antibody Products:
Assay Products for MKL1: |
Protein
Domains /
Families
for MKL1 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
MKL1 for domains About GeneDecksing
2 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry Q969V6ProtoNet protein and cluster: Q969V6 1 Blocks protein family: IPB003034 DNA-binding SAP
UniProtKB/Swiss-Prot: MKL1_HUMAN, Q969V6Domain: The N-terminal region is required for nuclear localization and the C-terminal region mediates transcriptionalactivity (By similarity)Domain: The RPEL repeats mediate binding to globular actin (By similarity)Similarity: Contains 2 RPEL repeatsSimilarity: Contains 1 SAP domain |
Function
for MKL1 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: MKL1_HUMAN, Q969V6Function: Transcriptional coactivator of serum response factor (SRF) with the potential to modulate SRF target genes.Suppresses TNF-induced cell death by inhibiting activation of caspases; its transcriptional activity is indispensablefor the antiapoptotic function. It may up-regulate antiapoptotic molecules, which in turn inhibit caspase activation(By similarity)
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for MKL1 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for MKL1
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: MKL1 (NM_020831) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for MKL1 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MKL1 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MKL1 |
Gene Ontology (GO): 5/8 molecular function terms (GO ID links to tree view) (see all 8): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0000976 | transcription regulatory region sequence-specific DNA binding |
IEA | -- | | GO:0003676 | nucleic acid binding |
-- | -- | | GO:0003700 | sequence-specific DNA binding transcription factor activity |
IEA | -- | | GO:0003713 | transcription coactivator activity |
ISS | -- | | GO:0003779 | actin binding |
-- | -- |
MKL1 for ontologies About GeneDecksing
2 GenomeRNAi human phenotypes for MKL1:
Animal Models:
Mouse knock-outs for MKL1: Mkl1tm1Eno Mkl1tm1Swm
10 MGI mutant phenotypes (inferred from 2 alleles ) (MGI details for Mkl1):
MKL1 for phenotypes About GeneDecksing
|
Pathways & Interactions
for MKL1 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Unified GeneCards pathways About this table
See pathways by source
| Super-pathway | contained gene-specific pathways |
|---|
| 1 | RhoA signaling pathway | |
1  BioSystems Pathway for MKL1
Interactions:
SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for MKL1
STRING Interaction
Network Preview (showing 5 interactants - click image to see 22)
5/23 Interacting proteins for MKL1 (Q969V61, 3 ENSP000003478474) via UniProtKB, MINT, STRING, and/or I2D (see all 23)About this table
Gene Ontology (GO): 5 biological process terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0006351 | transcription, DNA-dependent |
IEA | -- | | GO:0043066 | negative regulation of apoptotic process |
IEA | -- | | GO:0045893 | positive regulation of transcription, DNA-dependent |
-- | -- | | GO:0045944 | positive regulation of transcription from RNA polymerase II promoter |
IDA | 14970199 | | GO:0051145 | smooth muscle cell differentiation |
IMP | 14970199 |
MKL1 for ontologies About GeneDecksing
|
Drugs & Compounds
for MKL1 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for MKL1
1 DrugBank Compound for MKL1 About this table
Search CenterWatch for drugs/clinical trials and news about MKL1
|
Transcripts
for MKL1 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for MKL1 gene: NM_020831.3 Unigene Cluster for MKL1: Megakaryoblastic leukemia (translocation) 1 Hs.654688 [show with all ESTs]Unigene Representative Sequence: BC1150399 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000355630(uc003ayw.1 uc010gyf.1) ENST00000402042(uc003ayy.1)
ENST00000407029(uc003ayv.1) ENST00000477468 ENST00000402630 ENST00000422851
ENST00000463769 ENST00000466278 ENST00000396617(uc010gye.1)
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for MKL1 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for MKL1
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: MKL1 (NM_020831) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for MKL1 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MKL1 |
Additional cDNA sequence: AB037859.2 AF364036.1 AF368061.1 AF448806.1 AJ297257.1 AJ297258.1 AK096572.1 AL713710.1 BC021586.1 BC064620.1 BC114364.2 BC115039.1 BC139730.1 CR456522.1 19 DOTS entries: DT.444588 DT.95184304 DT.101956357 DT.120648981 DT.120649186 DT.120648927 DT.100811784 DT.100784960 DT.92433928 DT.92433925 DT.100784963 DT.95184312 DT.91725374 DT.120648898 DT.120649206 DT.120649231 DT.92433929 DT.95184308 DT.99936766 24/185 AceView cDNA sequences (see all 185): AI291129 AI925855 AI634330 AB037859 AI365472 BU506937 BM717885 CD364623 AI276105 BG149179 AI239731 AI342654 BE222427 BM806687 AL713710 BE670629 BQ898598 BI914082 NM_020831 BF345634 AA721352 AW475017 BX113210 CF541115
GeneLoc Exon Structure
5/6 Alternative Splicing Database (ASD) splice patterns (SP) for MKL1 (see all 6) About this scheme
| ExUns: | 1a | · | 1b | · | 1c | ^ | 2 | ^ | 3a | · | 3b | ^ | 4 | ^ | 5 | ^ | 6 | ^ | 7 | ^ | 8 | ^ | 9 | ^ | 10 | ^ | 11 | ^ | 12 | ^ | 13 |
|---|
|
| SP1: | | | | | | | | | | | - | | - | | | | | | | | | | | | | | | | | | | | |
| SP2: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP3: | | | | | | | - | | | | - | | - | | | | | | | | | | | | | | | | | | | | |
| SP4: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP5: | | | | | | | - | | | | - | | | | | | | | | | | | | | | | | | | | | |
ECgene alternative splicing isoforms for MKL1
|
Expression
for MKL1 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| MKL1 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: AGGGCAGAGG
About this image
See MKL1 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for MKL1
SOURCE GeneReport for Unigene cluster: Hs.654688
UniProtKB/Swiss-Prot: MKL1_HUMAN, Q969V6Tissue specificity: Ubiquitously expressed, has been detected in lung, placenta, small intestine, liver, kidney,spleen, thymus, colon, muscle, heart and brain
SABiosciences Expression via Pathway-Focused PCR Array including MKL1:
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for MKL1
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat MKL1 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat MKL1 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat MKL1 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MKL1 |
Orthologs
for MKL1 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of animals.
Orthologs for MKL1 gene from 5/21 species (see all 21) About this table
| Organism |
Taxonomic
classification |
Gene |
Description |
Human
Similarity |
Orthology
Type |
Details |
chicken
(Gallus gallus) |
Aves |
MKL11 |
megakaryoblastic leukemia (translocation) 1 |
74.84(n)
76.04(a) |
|
418005 XM_416243.3 XP_416243.3 |
lizard
(Anolis carolinensis) |
Reptilia |
B9TVS8_ANOCA6 |
Megakaryoblastic leukemia 1 protein Fragment |
51(a) |
1 ↔ 1 |
5(25842261-25843187) |
African clawed frog
(Xenopus laevis) |
Amphibia |
MRTF-A2 |
myocardin-related transcription factor A |
76.93(n) |
|
AF532599.1 |
zebrafish
(Danio rerio) |
Actinopterygii |
LOC7974801 |
MKL/myocardin-like protein 1-like |
54.62(n)
51.52(a) |
|
797480 XM_001337902.4 XP_001337938.4 |
fruit fly
(Drosophila melanogaster) |
Insecta |
Mrtf6 |
Myocardin-related transcription factor |
11(a) |
1 → many |
3L(2717615-2766480) |
ENSEMBL Gene Tree for MKL1 (if available)
TreeFam Gene Tree for MKL1 (if available) |
Paralogs
for MKL1 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for MKL1 gene
- MYOCD2 MKL22
2 SIMAP similar genes for MKL1 using alignment to 8 protein entries: MKL1_HUMAN (see all proteins):MKL2 MYOCD
MKL1 for paralogs About GeneDecksing
|
Genomic Variants
for MKL1 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 22 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for MKL1 (40806285 - 41032706 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 5 variations for MKL1
4 CNVs: 36031 91065 79581 91066
1 Indel: 79580
Human Gene Mutation Database (HGMD): MKL1
| SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing MKL1 |
|
Disorders
/ Diseases
for MKL1 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database, Novoseek,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
MKL1 for disorders About GeneDecksing
OMIM gene information: 606078
OMIM disorders: --
UniProtKB/Swiss-Prot: MKL1_HUMAN, Q969V6
Note=A chromosomal aberration involving MKL1 may be a cause of acute megakaryoblastic leukemia. Translocationt(1;22)(p13;q13) with RBM15. Although both reciprocal fusion transcripts are detected in acute megakaryoblasticleukemia (AMKL, FAB-M7), the RBM15-MKL1 chimeric protein has all the putative functional domains encoded by each geneand is the candidate oncogene
11  diseases for MKL1: About MalaCardsmegakaryoblastic leukemia leukemia megakaryocytic leukemia acute leukemia
cancer progression/metastasis acute megakaryoblastic leukemia endocarditis infective endocarditis
acute myeloid leukemia myeloid leukemia ovarian cancer
1 disease from the University of Copenhagen DISEASES database for MKL1:Leukemia 2 Novoseek disease relationships for MKL1 gene About this table
Human Genome Epidemiology (HuGE) Navigator: MKL1 (1 document)
Export disorders for MKL1 gene to outside databases
|
Publications
for MKL1 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for MKL1 gene, integrated from 9 sources (see all 86):
(articles sorted by number of sources associating them with MKL1) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Fusion of two novel genes, RBM15 and MKL1, in the t(1;22)(p13;q13) of acute megakaryoblastic leukemia. (PubMed id 11431691)1, 2, 3, 9 Ma Z.... Hitzler J.K. (2001)
- Megakaryoblastic leukemia factor-1 transduces cytoskeletal signals and induces smooth muscle cell differentiation from undifferentiated embryonic stem cells. (PubMed id 14970199)1, 3, 9 Du K.L....Parmacek M.S. (2004)
- Identification of a novel transcriptional activator, BSAC, by a functional cloning to inhibit tumor necrosis factor-induced cell dea th. (PubMed id 12019265)1, 3, 9 Sasazuki T....Nakano H. (2002)
- Involvement of a human gene related to the Drosophila spen gene in the recurrent t(1;22) translocation of acute megakaryocytic leukemia. (PubMed id 11344311)1, 2, 9 Mercher T....Bernard O.A. (2001)
- SCAI acts as a suppressor of cancer cell invasion through the transcriptional control of beta1-integrin. (PubMed id 19350017)1, 2 Brandt D.T.... Grosse R. (2009)
- Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PubMed id 17081983)1, 2 Olsen J.V....Mann M. (2006)
- A genome annotation-driven approach to cloning the human ORFeome. (PubMed id 15461802)1, 2 Collins J.E.... Dunham I. (2004)
- Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones. (PubMed id 12168954)1, 2 Nakajima D.... Nagase T. (2002)
- Prediction of the coding sequences of unidentified human genes. XVI. The complete sequences of 150 new cDNA clones from brain which code for large proteins in vitro. (PubMed id 10718198)1, 2 Nagase T.... Ohara O. (2000)
- The DNA sequence of human chromosome 22. (PubMed id 10591208)1, 2 Dunham I....O'Brien K.P. (1999)
|
External Searches for MKL1 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing MKL1 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing MKL1 gene
(According to HUGE)
About This Section
| |
Specialized Databases showing MKL1 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
|
About This Section
| Patent Information for MKL1 gene:
Search GeneIP for patents involving MKL1
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for MKL1 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for MKL1 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for MKL1 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for MKL1 | | | Browse OriGene Protein Over-expression Lysates | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for MKL1 | | OriGene 3'-UTR Clone for MKL1 | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for MKL1 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for MKL1 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for MKL1 | | OriGene Custom Protein Services for MKL1 | | | OriGene Custom Immunoassay Development | | |
| |
 |
 |
| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat MKL1 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing MKL1 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat MKL1 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat MKL1 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat MKL1 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat MKL1 |
| |
 |  |  |  | |
| | | | Search Tocris compounds for MKL1 |
| |  |  |  |  | | | | |
 |
 |
 |
 | | | MKL1 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MKL1 |
|  |  |  | | | | Search ThermoFisher Antibodies for MKL1 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MKL1 |
|
|
|
|
