MKKS Gene
protein-coding GIFtS: 53
GCID: GC20M010385
|
|
McKusick-Kaufman syndrome (Previous symbol: BBS6)
| |
Aliases for MKKS gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb) About This Section
|
| Aliases |
|---|
| McKusick-Kaufman Syndrome1 2 | | KMS2 5 | | BBS61 2 3 5 | | MKS2 5 | | Bardet-Biedl Syndrome 6 Protein2 3 | | McKusick-Kaufman/Bardet-Biedl Syndromes Putative Chaperonin2 | | HMCS2 5 | | |
Export aliases for MKKS gene to outside databasesPrevious GC identifers: GC20M010373 GC20M010333 GC20M010380 GC20M010337 |
Summaries for MKKS gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
| Entrez Gene summary for MKKS: This gene encodes a protein which shares sequence similarity with other members of the chaperonin family. The encodedprotein may have a role in protein folding, processing and assembly. Mutations in this gene have been observed inpatients with Bardet-Biedl syndrome type 6 and McKusick-Kaufman syndrome. Alternative splicing results in multipletranscript variants. (provided by RefSeq, Jun 2012) UniProtKB/Swiss-Prot: MKKS_HUMAN, Q9NPJ1Function: Probable molecular chaperone. Assists the folding of proteins upon ATP hydrolysis. As part of the BBS/CCTcomplex may play a role in the assembly of BBSome, a complex involved in ciliogenesis regulating transports vesiclesto the cilia. May play a role in protein processing in limb, cardiac and reproductive system development. May play arole in cytokinesis Gene Wiki entry for MKKS
|
Genomic Views for MKKS gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics) About This Section
| RefSeq DNA sequence:- NC_000020.10 NC_018931.1 NT_011387.8
Regulatory elements: SABiosciences Regulatory transcription factor binding sites in the MKKS gene promoter: SRF USF1 SRF (504 AA) USF-1 FOXD3 Other transcription factors
Search SABiosciences Chromatin IP Primers for MKKS
Epigenetics:
|  | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat MKKS |
Genomic Location: Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 20p12 Ensembl cytogenetic band: 20p12.2 HGNC cytogenetic band: 20p12MKKS Gene in genomic location: bands according to Ensembl, locations according to
(and/or Entrez Gene and/or Ensembl if different)

GeneLoc information about chromosome 20 GeneLoc Exon Structure GeneLoc location for GC20M010385: view genomic region
(about GC identifiers)
Start:
|
10,385,832 bp from pter |
End:
|
10,414,870 bp from pter |
Size:
|
29,039 bases |
Orientation:
|
minus strand |
|
Proteins for MKKS gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
| UniProtKB/Swiss-Prot: MKKS_HUMAN, Q9NPJ1 (See
protein sequence)Recommended Name: McKusick-Kaufman/Bardet-Biedl syndromes putative chaperonin Size: 570 amino acids; 62342 Da
Subunit: Component of the BBS/CCT complex composed at least of MKKS, BBS10, BBS12, TCP1, CCT2, CCT3, CCT4, CCT5 ANDCCT8. Interacts with STUB1. Interacts with BBS2 (via coiled coil domain). Interacts with CCDC28B
Subcellular location: Cytoplasm, cytoskeleton, centrosome. Cytoplasm, cytosol. Note=The majority of the protein resideswithin the pericentriolar material (PCM), a proteinaceous tube surrounding centrioles. During interphase, the proteinis confined to the lateral surfaces of the PCM but during mitosis it relocalizes throughout the PCM and is found atthe intercellular bridge. The MKSS protein is highly mobile and rapidly shuttles between the cytosol and centrosome
Secondary accessions: A8K7B0 D3DW18Explore the universe of human proteins at neXtProt for MKKS: NX_Q9NPJ1
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q9NPJ1 MKKS Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins (2 alternative transcripts):
NP_061336.1 NP_740754.1 ENSEMBL proteins: ENSP00000382008 ENSP00000246062 Human Recombinant Protein Products:
Gene Ontology (GO): 4 cellular component terms (GO ID links to tree view): About this table
MKKS for ontologies About GeneDecksing
MKKS Antibody Products: Assay Products for MKKS: |
Protein
Domains / Families for MKKS gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
MKKS for domains About GeneDecksing
1 InterPro domain/family:Graphical View of Domain Structure for InterPro Entry Q9NPJ1ProtoNet protein and cluster: Q9NPJ1 UniProtKB/Swiss-Prot: MKKS_HUMAN, Q9NPJ1Domain: The substrate-binding apical domain region is sufficient for centrosomal associationSimilarity: Belongs to the TCP-1 chaperonin family |
Function for MKKS gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
| Function Summary: UniProtKB/Swiss-Prot: MKKS_HUMAN, Q9NPJ1Function: Probable molecular chaperone. Assists the folding of proteins upon ATP hydrolysis. As part of the BBS/CCTcomplex may play a role in the assembly of BBSome, a complex involved in ciliogenesis regulating transports vesiclesto the cilia. May play a role in protein processing in limb, cardiac and reproductive system development. May play arole in cytokinesis
Clone Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for MKKS (see all 5) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for MKKS (see all 3) OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector (see all 2): MKKS (NM_170784) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for MKKS | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MKKS  |
In Situ Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MKKS |
Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view): About this table
MKKS for ontologies About GeneDecksing
Animal Models: Mouse knock-out Mkkstm1Vcs for MKKS 13 MGI mutant phenotypes (inferred from 2 alleles ) (MGI details for Mkks):
MKKS for phenotypes About GeneDecksing
|
Pathways & Interactions for MKKS gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for MKKS
STRING Interaction
Network Preview (showing 5 interactants - click image to see 17)
 5/18 Interacting proteins for MKKS (Q9NPJ11, 2, 3 ENSP000002460624) via UniProtKB, MINT, STRING, and/or I2D (see all 18)About this table
Gene Ontology (GO): 5/31 biological process terms (GO ID links to tree view) (see all 31): About this table
MKKS for ontologies About GeneDecksing
|
Drugs & Compounds for MKKS gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
MKKS for compounds About GeneDecksing
Browse Tocris compounds for MKKS 4 Novoseek chemical compound relationships for MKKS gene About this table
Search CenterWatch for drugs/clinical trials and news about MKKS 
|
Transcripts for MKKS gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank, RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
) About This Section
| REFSEQ mRNAs for MKKS gene (2 alternative transcripts): NM_018848.3 NM_170784.2 Unigene Clusters for MKKS: McKusick-Kaufman syndrome Hs.472119 [show with all ESTs], Hs.741430 [show with all ESTs]Unigene Representative Sequences: NM_018848, CF7806322 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000399054(uc002wnt.1) ENST00000347364(uc002wnu.1 uc010zrd.1)
Clone Products: |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for MKKS (see all 5) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for MKKS (see all 3) OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector (see all 2): MKKS (NM_170784) | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for MKKS | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MKKS  |
Additional cDNA sequence: BC009180.1 BC013287.1 10 DOTS entries: DT.452020 DT.95282801 DT.95070585 DT.91746002 DT.95282790 DT.100818446 DT.40298117 DT.120801002 DT.91705394 DT.92012295 24/207 AceView cDNA sequences (see all 207): AI242362 CD676766 BQ677656 BQ423217 NM_018848 AI248335 CB133122 AI185484 AF221993 BM765598 AI609156 BE646191 AI292350 BM772193 BM558221 CB124359 AI494301 BM772822 AV708868 AF221992 AI247477 AA603212 BU526879 AA643939 GeneLoc Exon Structure
5/6 Alternative Splicing Database (ASD) splice patterns (SP) for MKKS (see all 6) About this scheme
| ExUns: | 1 | ^ | 2 | ^ | 3 | ^ | 4 | ^ | 5a | · | 5b | ^ | 6a | · | 6b | · | 6c | ^ | 7 | ^ | 8a | · | 8b | · | 8c | |
| SP1: | |   | - |   | - |   | |   | |   | |   | - |   | |   | |   | |   | |   | |   | |   | |
| SP2: | |   | |   | - |   | |   | |   | |   | - |   | |   | |   | |   | |   | |   | |   | |
| SP3: | |   | - |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |
| SP4: | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |
| SP5: | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   |
ECgene alternative splicing isoforms for MKKS
|
Expression for MKKS gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| MKKS expression in normal human tissues (normalized intensities) See probesets specificity/sensitivity at GeneAnnot About this imageBioGPS CGAP TAG: TTCGTATTAC
About this image See MKKS Protein Expression from SPIRE MOPED and PaxDB Genevestigator expression for MKKS
SOURCE GeneReport for Unigene clusters: Hs.472119 Hs.741430 UniProtKB/Swiss-Prot: MKKS_HUMAN, Q9NPJ1Tissue specificity: Widely expressed in adult and fetal tissues SABiosciences Expression via Pathway-Focused PCR Array including MKKS:
Primer Products: |  | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for MKKS Browse OriGene validated miRNA SYBR primer pairs
| |  | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat MKKS | |  | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat MKKS | |  | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat MKKS | In Situ Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MKKS |
Orthologs for MKKS gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of chordates.
Orthologs for MKKS gene from 5/15 species (see all 15) About this table
ENSEMBL Gene Tree for MKKS (if available) TreeFam Gene Tree for MKKS (if available)  |
Paralogs for MKKS gene(Paralogs according to
1HomoloGene, 2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68) About This Section
| -- |
Genomic Variants for MKKS gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical significance | Chr 20 pos | Sequence | # | AA Chg | Type | More | # | Allele freq | Pop | Total sample | More |
|---|
HapMap Linkage Disequilibrium report for MKKS (10385832 - 10414870 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions) Database of Genomic Variants (DGV): 1 variation for MKKS 1 CNV: 90460 Human Gene Mutation Database (HGMD): MKKS
Locus Specific Mutation Databases (LSDB): MKKS
 | SABiosciences Cancer Mutation PCR Assays |
|  | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing MKKS |
|
Disorders
/ Diseases for MKKS gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database, Novoseek,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
MKKS for disorders About GeneDecksing
OMIM gene information: 604896 OMIM disorders: 236700 209900 UniProtKB/Swiss-Prot: MKKS_HUMAN, Q9NPJ1
Defects in MKKS are the cause of McKusick-Kaufman syndrome (MKKS) [MIM:236700]. MKKS is an autosomal recessivedevelopmental disorder. It is characterized by hydrometrocolpos, postaxial polydactyly and congenital heart defects Defects in MKKS are the cause of Bardet-Biedl syndrome type 6 (BBS6) [MIM:209900]. Bardet-Biedl syndrome (BBS)is a genetically heterogeneous, autosomal recessive disorder characterized by usually severe pigmentary retinopathy,early onset obesity, polydactyly, hypogenitalism, renal malformation and mental retardation. Secondary featuresinclude diabetes mellitus, hypertension and congenital heart disease. A relatively high incidence of BBS is found inthe mixed Arab populations of Kuwait and in Bedouin tribes throughout the Middle East, most likely due to the highrate of consaguinity in these populations and a founder effect 20/30 diseases for MKKS (see all 30): About MalaCardsmckusick-kaufman syndrome bardet-biedl syndrome bardet-biedl syndrome 6 ellis-van creveld syndrome thrombocytopenia-absent radius syndrome laurence-moon syndrome pallister-hall syndrome joubert syndrome and related disorders joubert syndrome pigmentary retinopathy tetralogy of fallot fundus dystrophy retinal degeneration was-related disorders meckel syndrome polydactyly rheumatoid arthritis retinitis renal cell carcinoma prostate cancer, progression of
7 diseases from the University of Copenhagen DISEASES database for MKKS:Polydactyly Ellis-Van Creveld syndrome Pallister-Hall syndrome Congenital heart defect Laurence-Moon syndrome Retinitis pigmentosa Fundus dystrophy 10 Novoseek disease relationships for MKKS gene About this table
GeneTests: MKKS McKusick-Kaufman SyndromeBardet-Biedl Syndrome Genetic Association Database (GAD): MKKS Human Genome Epidemiology (HuGE) Navigator: MKKS (10 documents) Export disorders for MKKS gene to outside databases
|
Publications for MKKS gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for MKKS gene, integrated from 9 sources (see all 98): (articles sorted by number of sources associating them with MKKS) | |  | Utopia: connect your pdf to the dynamic world of online information |
- Variation of the McKusick-Kaufman gene and studies of relationships with common forms of obesity. (PubMed id 15483080)1, 2, 4 Andersen K.L....Pedersen O. (2005)
- MKKS/BBS6, a divergent chaperonin-like protein linked to the obesity disorder Bardet-Biedl syndrome, is a novel centrosomal component required for cytokinesis. (PubMed id 15731008)1, 2, 9 Kim J.C.... Leroux M.R. (2005)
- Genetic and mutational analyses of a large multiethnic Bardet-Biedl cohort reveal a minor involvement of BBS6 and delineate the critical intervals of other loci. (PubMed id 11179009)1, 2, 9 Beales P.L....Lupski J.R. (2001)
- Triallelic inheritance in Bardet-Biedl syndrome, a mendelian recessive disorder. (PubMed id 11567139)1, 2, 9 Katsanis N.... Lupski J.R. (2001)
- MKKS is a centrosome-shuttling protein degraded by disease-causing mutations via CHIP-mediated ubiquitination. (PubMed id 18094050)1, 2 Hirayama S.... Nagata K. (2008)
- Dissection of epistasis in oligogenic Bardet-Biedl syndrome. (PubMed id 16327777)1, 2 Badano J.L....Katsanis N. (2006)
- Heterozygous mutations in BBS1, BBS2 and BBS6 have a potential epistatic effect on Bardet-Biedl patients with two mutations at a second BBS locus. (PubMed id 12837689)1, 2 Badano J.L.... Katsanis N. (2003)
- Mutation analysis of the MKKS gene in McKusick-Kaufman syndrome and selected Bardet-Biedl syndrome patients. (PubMed id 12107442)1, 2 Slavotinek A.M.... Biesecker L.G. (2002)
- The DNA sequence and comparative analysis of human chromosome 20. (PubMed id 11780052)1, 2 Deloukas P....Rogers J. (2001)
- Mutations in MKKS cause obesity, retinal dystrophy and renal malformations associated with Bardet-Biedl syndrome. (PubMed id 10973251)1, 2 Katsanis N.... Lupski J.R. (2000)
|
External Searches for MKKS gene
(in PubMed,
OMIM, and NCBI Bookshelf) About This Section
|
|
Genome Databases showing MKKS gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing MKKS gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing MKKS gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL, Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot) About This Section
|
| Name | Description |
| PharmGKB entry for MKKS | Pharmacogenomics, SNPs, Pathways | | Mutations of the MKKS gene | http://www.retina-international.org/files/sci-news/mkksmut.htm | | GeneReviews | http://www.ncbi.nlm.nih.gov/sites/GeneTests/lab/gene/MKKS |
|
| | |
About This Section
| Patent Information for MKKS gene: Search GeneIP for patents involving MKKS
GeneCards and IP: Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products for MKKS gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences), In Situ Hybridization Assays from Advanced Cell Diagnostics About This Section
|
 | |
 | |
 |
| | | | Browse OriGene Antibodies | | OriGene shRNA RFP for MKKS | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for MKKS | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for MKKS | | Browse OriGene Protein Over-expression Lysates | | Browse OriGene Fluorogenic Cell Assay Kits | | OriGene siRNA for MKKS | | OriGene 3'-UTR Clone for MKKS | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for MKKS | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for MKKS | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | OriGene Custom Antibody Services for MKKS | | OriGene Custom Protein Services for MKKS | | OriGene Custom Immunoassay Development | | |
| |  |
 |
| | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat MKKS | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing MKKS | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat MKKS | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat MKKS | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat MKKS | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat MKKS |
| |
 |  |  |  | |
| | | Search Tocris compounds for MKKS |
| |  |  |  |  | | | | |
 |
 |
 |
 | | MKKS Proteins, Antibodies, CLIAs, and ELISAs |
| | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MKKS |
|  |  |  | | | Search ThermoFisher Antibodies for MKKS |
| | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MKKS |
|
|
|
|