MKI67IP Gene
protein-coding GIFtS: 49
GCID: GC02M122484
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MKI67 (FHA domain) interacting nucleolar phosphoprotein
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Aliases for MKI67IP gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb) About This Section
|
| Aliases |
|---|
| MKI67 (FHA Domain) Interacting Nucleolar Phosphoprotein1 2 | | Nucleolar Protein Interacting With The FHA Domain Of PKI-672 3 | | NIFK1 2 3 5 | | HNIFK1 | | Nopp341 2 | | NOPP343 5 | | Nucleolar Phosphoprotein Nopp342 3 | | MKI67 FHA Domain-Interacting Nucleolar Phosphoprotein2 |
Export aliases for MKI67IP gene to outside databasesPrevious GC identifers: GC02M119689 GC02M120404 GC02M122391 GC02M122579 GC02M122200 GC02M114807 |
Summaries for MKI67IP gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
| Entrez Gene summary for MKI67IP: This gene encodes a protein that interacts with the forkhead-associated domain of the Ki-67 antigen. The encodedprotein may bind RNA and may play a role in mitosis and cell cycle progression. Multiple pseudogenes exist onchromosomes 5, 10, 12, 15, and 19.(provided by RefSeq, Jan 2009) Gene Wiki entry for MKI67IP
|
Genomic Views for MKI67IP gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics) About This Section
| RefSeq DNA sequence:- NC_000002.11 NC_018913.1 NT_022135.16
Regulatory elements: SABiosciences Regulatory transcription factor binding sites in the MKI67IP gene promoter: Max1 AhR GR Sox5 HNF-1A Arnt PPAR-alpha HNF-1 GR-alpha Other transcription factors
Search SABiosciences Chromatin IP Primers for MKI67IP
Epigenetics:
|  | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat MKI67IP |
Genomic Location: Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 2q14.3 Ensembl cytogenetic band: 2q14.3 HGNC cytogenetic band: 2q14.3MKI67IP Gene in genomic location: bands according to Ensembl, locations according to
(and/or Entrez Gene and/or Ensembl if different)

GeneLoc information about chromosome 2 GeneLoc Exon Structure GeneLoc location for GC02M122484: view genomic region
(about GC identifiers)
Start:
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122,484,521 bp from pter |
End:
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122,494,503 bp from pter |
Size:
|
9,983 bases |
Orientation:
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minus strand |
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Proteins for MKI67IP gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
| UniProtKB/Swiss-Prot: MK67I_HUMAN, Q9BYG3 (See
protein sequence)Recommended Name: MKI67 FHA domain-interacting nucleolar phosphoprotein Size: 293 amino acids; 34222 Da
Subunit: Binds to the FHA domain of MKI67; this interaction is enhanced in mitosis
Subcellular location: Nucleus, nucleolus. Chromosome. Note=Localizes to mitotic chromosomes in conjunction with MKI67
1 PDB 3D structure from and Proteopedia for MKI67IP:2AFF (3D)
 
Secondary accessions: A8K788 Q8TB66 Q96ED4Explore the universe of human proteins at neXtProt for MKI67IP: NX_Q9BYG3
Post-translational modifications:
Sequentially phosphorylated on Thr-238, Thr-234 and Ser-230. Thr-234 is phosphorylated only when Thr-238 isphosphorylated. Likewise, phosphorylation at Ser-230 requires that Thr-234 and Thr-238 are phosphorylated.Phosphorylation enhances MKI67 binding1
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q9BYG3 MKI67IP Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_115766.3 ENSEMBL proteins: ENSP00000285814 ENSP00000386449 ENSP00000390174 ENSP00000406227 ENSP00000398116 Human Recombinant Protein Products:
Gene Ontology (GO): 4 cellular component terms (GO ID links to tree view): About this table
MKI67IP for ontologies About GeneDecksing
MKI67IP Antibody Products: Assay Products for MKI67IP: |
Protein
Domains / Families for MKI67IP gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
MKI67IP for domains About GeneDecksing
3 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry Q9BYG3ProtoNet protein and cluster: Q9BYG3 1 Blocks protein family: IPB000504 RNA-binding region RNP-1 (RNA recognition motif)
UniProtKB/Swiss-Prot: MK67I_HUMAN, Q9BYG3Similarity: Contains 1 RRM (RNA recognition motif) domain |
Function for MKI67IP gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Clone Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for MKI67IP (see all 3) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for MKI67IP OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: MKI67IP (NM_032390) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for MKI67IP | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MKI67IP  |
In Situ Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MKI67IP |
Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view): About this table
MKI67IP for ontologies About GeneDecksing
1 GenomeRNAi human phenotype for MKI67IP:
|
Pathways & Interactions for MKI67IP gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for MKI67IP
STRING Interaction
Network Preview (showing 5 interactants - click image to see 25)
 5/97 Interacting proteins for MKI67IP (Q9BYG32, 3 ENSP000002858144) via UniProtKB, MINT, STRING, and/or I2D (see all 97)About this table
Gene Ontology (GO): 4 biological process terms (GO ID links to tree view): About this table
MKI67IP for ontologies About GeneDecksing
|
Drugs & Compounds for MKI67IP gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
Browse Tocris compounds for MKI67IP Search CenterWatch for drugs/clinical trials and news about MKI67IP / MK67I 
|
Transcripts for MKI67IP gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank, RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
) About This Section
| REFSEQ mRNAs for MKI67IP gene: NM_032390.4 Unigene Cluster for MKI67IP: MKI67 (FHA domain) interacting nucleolar phosphoprotein Hs.367842 [show with all ESTs]Unigene Representative Sequence: NM_0323908 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000285814(uc002tnk.3) ENST00000409201 ENST00000423105 ENST00000481978 ENST00000498570 ENST00000447132 ENST00000451734 ENST00000477693(uc010fls.3)
Clone Products: |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for MKI67IP (see all 3) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for MKI67IP OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: MKI67IP (NM_032390) | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for MKI67IP | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MKI67IP  |
Additional cDNA sequence: AB044971.1 AK027097.1 AK291903.1 AK299814.1 AK311033.1 BC012457.1 BC022990.1 BC024238.2 10 DOTS entries: DT.416793 DT.97845050 DT.92450601 DT.97778505 DT.121000388 DT.97804207 DT.100028979 DT.100733042 DT.92450605 DT.99995751 24/350 AceView cDNA sequences (see all 350): BF589119 BG058573 AI497673 AW960765 BM799591 BP336789 AA765363 BE042711 BC012457 CR620927 BF063907 AA513403 AA456437 BF149128 BC022990 BU190916 BU198391 AA639548 BM505270 AI217616 BU620726 AI668969 BM974502 AA281395 GeneLoc Exon Structure
3 Alternative Splicing Database (ASD) splice patterns (SP) for MKI67IP About this scheme
| ExUns: | 1 | ^ | 2a | · | 2b | ^ | 3 | ^ | 4a | · | 4b | ^ | 5 | ^ | 6 | ^ | 7a | · | 7b | · | 7c | |
| SP1: | |   | - |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |
| SP2: | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |
| SP3: | |   | |   | |   | |   | |   | |   | - |   | |   | |   | |   | |   |
ECgene alternative splicing isoforms for MKI67IP
|
Expression for MKI67IP gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| MKI67IP expression in normal human tissues (normalized intensities) See probesets specificity/sensitivity at GeneAnnot About this imageBioGPS CGAP TAG: AATTAATAAC
About this image See MKI67IP Protein Expression from SPIRE MOPED and PaxDB Genevestigator expression for MKI67IP
SOURCE GeneReport for Unigene cluster: Hs.367842 SABiosciences Custom PCR Arrays for MKI67IP
Primer Products: |  | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for MKI67IP Browse OriGene validated miRNA SYBR primer pairs
| |  | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat MKI67IP | |  | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat MKI67IP | |  | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat MKI67IP | In Situ Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MKI67IP |
Orthologs for MKI67IP gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of eukaryotes.
Orthologs for MKI67IP gene from 9/30 species (see all 30) About this table
| Organism |
Taxonomic classification |
Gene |
Description |
Human Similarity |
Orthology Type |
Details |
mouse (Mus musculus) |
Mammalia |
Mki67ip1 , 5 |
Mki67 (FHA domain) interacting nucleolar phosphoprotein1, 5 |
69.64(n)1 62.2(a)1 |
  |
1 (52.14 cM)5 679491 NM_026472.41 NP_080748.31 1183218395 |
chicken (Gallus gallus) |
Aves |
MKI67IP1 |
MKI67 (FHA domain) interacting nucleolar phosphoprotein |
59.19(n) 54.75(a) |
  |
424239 XM_422088.2 XP_422088.1 |
lizard (Anolis carolinensis) |
Reptilia |
MKI67IP6 |
-- |
53(a) |
1 ↔ 1 |
3(2135472-2142996) |
African clawed frog (Xenopus laevis) |
Amphibia |
LOC3986452 |
hypothetical protein LOC398645 |
76.41(n) |
  |
BC054288.1 |
zebrafish (Danio rerio) |
Actinopterygii |
mki67ipl2 |
mki67 (FHA domain) interacting nucleolar phosphoprotein more |
79.12(n) |
  |
317644 AF506200.1 |
fruit fly (Drosophila melanogaster) |
Insecta |
CG69371 |
CG6937 |
43.51(n) 34.94(a) |
  |
42662 NM_142809.3 NP_651066.2 |
worm (Caenorhabditis elegans) |
Secernentea |
T04A8.66 |
Protein T04A8.6 |
20(a) |
1 ↔ 1 |
III(4692057-4693264) |
thale cress (Arabidopsis thaliana) |
eudicotyledons |
AT5G046001 |
RNA recognition motif-containing protein |
47.35(n) 37.5(a) |
  |
830337 NM_120542.4 NP_196080.1 |
rice (Oryza sativa) |
Liliopsida |
Os08g04122001 |
hypothetical protein |
47.71(n) 38.75(a) |
  |
4345558 NM_001068328.1 NP_001061793.1 |
ENSEMBL Gene Tree for MKI67IP (if available) TreeFam Gene Tree for MKI67IP (if available)  |
Paralogs for MKI67IP gene(Paralogs according to
1HomoloGene, 2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68) About This Section
| Paralogs for MKI67IP gene
MKI67IP for paralogs About GeneDecksing
5/12 Pseudogenes.org Pseudogenes for MKI67IP (see all 12) PGOHUM00000238710 PGOHUM00000239307 PGOHUM00000246855 PGOHUM00000246910 PGOHUM00000246911
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Genomic Variants for MKI67IP gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical significance | Chr 2 pos | Sequence | # | AA Chg | Type | More | # | Allele freq | Pop | Total sample | More |
|---|
HapMap Linkage Disequilibrium report for MKI67IP (122484521 - 122494503 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions) Database of Genomic Variants (DGV) variations for MKI67IP: --  | SABiosciences Cancer Mutation PCR Assays |
|  | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing MKI67IP |
|
Disorders
/ Diseases for MKI67IP gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
MKI67IP for disorders About MalaCards
MKI67IP for disorders About GeneDecksing
OMIM gene information: 611970
OMIM disorders: --
Export disorders for MKI67IP gene to outside databases
|
Publications for MKI67IP gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for MKI67IP gene, integrated from 9 sources (see all 27): (articles sorted by number of sources associating them with MKI67IP) | |  | Utopia: connect your pdf to the dynamic world of online information |
- A novel nucleolar protein, NIFK, interacts with the forkhead associated domain of Ki-67 antigen in mitosis. (PubMed id 11342549)1, 2, 3, 9 Takagi M.... Yoneda Y. (2001)
- Generation and annotation of the DNA sequences of human chromosomes 2 and 4. (PubMed id 15815621)1, 2 Hillier L.W....Wilson R.K. (2005)
- Sequential phosphorylation and multisite interactions characterize specific target recognition by the FHA domain of Ki67. (PubMed id 16244663)1, 2 Byeon I.-J.... Tsai M.-D. (2005)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- Structure of human Ki67 FHA domain and its binding to a phosphoprotein fragment from hNIFK reveal unique recognition sites and new views to the structural basis of FHA domain functions. (PubMed id 14659764)1, 2 Li H.... Tsai M.-D. (2004)
- A census of human soluble protein complexes. (PubMed id 22939629)1 Havugimana P.C....Emili A. (2012)
- Functional proteomics establishes the interaction of S IRT7 with chromatin remodeling complexes and expands its role in regulation of R NA polymerase I transcription. (PubMed id 22586326)1 Tsai Y.C....Cristea I.M. (2012)
- A catalogue of putative HIV-1 protease host cell subst rates. (PubMed id 22944692)1 Impens F....Gevaert K. (2012)
- Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (2011)
- Direct observations of shifts in the I^-sheet register of a protein-peptide complex using explicit solvent simulations. (PubMed id 21539773)1 Panteva M.T....Chong L.T. (2011)
|
External Searches for MKI67IP gene
(in PubMed,
OMIM, and NCBI Bookshelf) About This Section
|
|
Genome Databases showing MKI67IP gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing MKI67IP gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing MKI67IP gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL, Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot) About This Section
|
| Name | Description |
| PharmGKB entry for MKI67IP | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for MKI67IP gene: Search GeneIP for patents involving MKI67IP
GeneCards and IP: Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products for MKI67IP gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences), In Situ Hybridization Assays from Advanced Cell Diagnostics About This Section
|
 | |
 | |
 |
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 | | MKI67IP Proteins, Antibodies, CLIAs, and ELISAs |
| | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MKI67IP |
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