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Aliases for MKI67 Gene

Aliases for MKI67 Gene

  • Marker Of Proliferation Ki-67 2 3 5
  • Antigen Identified By Monoclonal Antibody Ki-67 2 3 4
  • Protein Phosphatase 1, Regulatory Subunit 105 2 3
  • Antigen Ki67 3 4
  • Proliferation-Related Ki-67 Antigen 3
  • Proliferation Marker Protein Ki-67 3
  • Antigen KI-67 4
  • PPP1R105 3
  • MIB-1 3
  • MIB- 3
  • KIA 3

External Ids for MKI67 Gene

Previous GeneCards Identifiers for MKI67 Gene

  • GC10M128707
  • GC10M128936
  • GC10M129824
  • GC10M129369
  • GC10M129784
  • GC10M123469
  • GC10M129894

Summaries for MKI67 Gene

Entrez Gene Summary for MKI67 Gene

  • This gene encodes a nuclear protein that is associated with and may be necessary for cellular proliferation. Alternatively spliced transcript variants have been described. A related pseudogene exists on chromosome X. [provided by RefSeq, Mar 2009]

GeneCards Summary for MKI67 Gene

MKI67 (Marker Of Proliferation Ki-67) is a Protein Coding gene. Diseases associated with MKI67 include Cervical Intraepithelial Neoplasia and Pancreatic Neuroendocrine Tumor. Among its related pathways are Primary Focal Segmental Glomerulosclerosis FSGS and Neuroscience. GO annotations related to this gene include poly(A) RNA binding and protein C-terminus binding.

UniProtKB/Swiss-Prot for MKI67 Gene

  • Required to maintain individual mitotic chromosomes dispersed in the cytoplasm following nuclear envelope disassembly (PubMed:27362226). Associates with the surface of the mitotic chromosome, the perichromosomal layer, and covers a substantial fraction of the chromosome surface (PubMed:27362226). Prevents chromosomes from collapsing into a single chromatin mass by forming a steric and electrostatic charge barrier: the protein has a high net electrical charge and acts as a surfactant, dispersing chromosomes and enabling independent chromosome motility (PubMed:27362226). Binds DNA, with a preference for supercoiled DNA and AT-rich DNA (PubMed:10878551). Does not contribute to the internal structure of mitotic chromosomes (By similarity). May play a role in chromatin organization (PubMed:24867636). It is however unclear whether it plays a direct role in chromatin organization or whether it is an indirect consequence of its function in maintaining mitotic chromosomes dispersed (Probable).

Gene Wiki entry for MKI67 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MKI67 Gene

Genomics for MKI67 Gene

Regulatory Elements for MKI67 Gene

Enhancers for MKI67 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH10F128149 1.1 Ensembl ENCODE 12.7 -23.7 -23743 1.5 ZNF76 KLF17 SIN3A ZNF2 RAD21 GLIS2 EGR1 SCRT2 ZNF143 ZNF207 MKI67 LINC01163
GH10F128147 0.2 Ensembl 12.7 -21.5 -21487 0.7 PKNOX1 JUND MTA2 CBX5 NBN MKI67 LINC01163
GH10F128148 0.2 ENCODE 12.7 -20.9 -20907 0.2 MTA2 CBX5 IKZF1 ZNF143 NBN RELA MKI67 LINC01163
GH10F128095 1.1 FANTOM5 Ensembl ENCODE 12.7 +30.4 30362 1.9 MAX GLIS2 JUND POLR2A ZNF341 GLIS1 PRDM10 BCL6 PRDM1 EGR2 MKI67 GC10M128107 GC10M128055
GH10F128085 0.8 Ensembl ENCODE 12.5 +39.8 39830 1.3 POLR2A SMARCA4 SP5 ATF2 MKI67 GC10M128055 GC10M128107
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around MKI67 on UCSC Golden Path with GeneCards custom track

Promoters for MKI67 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00001600893 385 2801 ELF3 TBP ARID4B SIN3A DMAP1 GLIS2 EGR1 FOS CREM EGR2

Genomic Location for MKI67 Gene

Chromosome:
10
Start:
128,096,659 bp from pter
End:
128,126,385 bp from pter
Size:
29,727 bases
Orientation:
Minus strand

Genomic View for MKI67 Gene

Genes around MKI67 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MKI67 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MKI67 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MKI67 Gene

Proteins for MKI67 Gene

  • Protein details for MKI67 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P46013-KI67_HUMAN
    Recommended name:
    Proliferation marker protein Ki-67
    Protein Accession:
    P46013
    Secondary Accessions:
    • Q5VWH2

    Protein attributes for MKI67 Gene

    Size:
    3256 amino acids
    Molecular mass:
    358694 Da
    Quaternary structure:
    • Interacts with KIF15 (PubMed:10878014). Interacts (via the FHA domain) with NIFK (PubMed:11342549, PubMed:14659764, PubMed:16244663). Interacts with PPP1CC (PubMed:24867636). Part of a complex composed at least of ASCL2, EMSY, HCFC1, HSPA8, CCAR2, MATR3, MKI67, RBBP5, TUBB2A, WDR5 and ZNF335; this complex may have a histone H3-specific methyltransferase activity (PubMed:19131338, PubMed:23178126).

    Three dimensional structures from OCA and Proteopedia for MKI67 Gene

    Alternative splice isoforms for MKI67 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for MKI67 Gene

Post-translational modifications for MKI67 Gene

  • Phosphorylated. Hyperphosphorylated in mitosis (PubMed:10502411, PubMed:10653604). Hyperphosphorylated form does not bind DNA.
  • Ubiquitination at Lys 659, Lys 666, Lys 745, Lys 1043, Lys 1549, Lys 1592, Lys 2138, and Lys 2289
  • Modification sites at PhosphoSitePlus

Other Protein References for MKI67 Gene

No data available for DME Specific Peptides for MKI67 Gene

Domains & Families for MKI67 Gene

Gene Families for MKI67 Gene

Protein Domains for MKI67 Gene

Suggested Antigen Peptide Sequences for MKI67 Gene

Graphical View of Domain Structure for InterPro Entry

P46013

UniProtKB/Swiss-Prot:

KI67_HUMAN :
  • Contains 1 FHA domain.
  • Contains 16 K167R repeats.
Domain:
  • Contains 1 FHA domain.
  • Contains 1 PP1-binding domain.
Similarity:
  • Contains 16 K167R repeats.
genes like me logo Genes that share domains with MKI67: view

Function for MKI67 Gene

Molecular function for MKI67 Gene

GENATLAS Biochemistry:
antigen identified by monoclonal antibody Ki-67 (non histone protein 395/345kDa)
UniProtKB/Swiss-Prot Function:
Required to maintain individual mitotic chromosomes dispersed in the cytoplasm following nuclear envelope disassembly (PubMed:27362226). Associates with the surface of the mitotic chromosome, the perichromosomal layer, and covers a substantial fraction of the chromosome surface (PubMed:27362226). Prevents chromosomes from collapsing into a single chromatin mass by forming a steric and electrostatic charge barrier: the protein has a high net electrical charge and acts as a surfactant, dispersing chromosomes and enabling independent chromosome motility (PubMed:27362226). Binds DNA, with a preference for supercoiled DNA and AT-rich DNA (PubMed:10878551). Does not contribute to the internal structure of mitotic chromosomes (By similarity). May play a role in chromatin organization (PubMed:24867636). It is however unclear whether it plays a direct role in chromatin organization or whether it is an indirect consequence of its function in maintaining mitotic chromosomes dispersed (Probable).

Gene Ontology (GO) - Molecular Function for MKI67 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 DNA binding IEA --
GO:0005515 protein binding IPI 10878014
GO:0005524 ATP binding IEA --
GO:0008022 protein C-terminus binding IPI 17577209
GO:0044822 poly(A) RNA binding IDA 22658674
genes like me logo Genes that share ontologies with MKI67: view
genes like me logo Genes that share phenotypes with MKI67: view

Animal Model Products

miRNA for MKI67 Gene

miRTarBase miRNAs that target MKI67

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for MKI67

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for MKI67 Gene

Localization for MKI67 Gene

Subcellular locations from UniProtKB/Swiss-Prot for MKI67 Gene

Chromosome. Nucleus. Nucleus, nucleolus. Note=Associates with the surface of the mitotic chromosome, the perichromosomal layer, and covers a substantial fraction of the mitotic chromosome surface (PubMed:27362226). Associates with satellite DNA in G1 phase (PubMed:9510506). Binds tightly to chromatin in interphase, chromatin-binding decreases in mitosis when it associates with the surface of the condensed chromosomes (PubMed:15896774, PubMed:22002106). Predominantly localized in the G1 phase in the perinucleolar region, in the later phases it is also detected throughout the nuclear interior, being predominantly localized in the nuclear matrix (PubMed:22002106). {ECO:0000269 PubMed:15896774, ECO:0000269 PubMed:22002106, ECO:0000269 PubMed:27362226}.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for MKI67 Gene COMPARTMENTS Subcellular localization image for MKI67 gene
Compartment Confidence
nucleus 5
cytoskeleton 2
mitochondrion 2
cytosol 1
extracellular 1
plasma membrane 1

Gene Ontology (GO) - Cellular Components for MKI67 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000775 chromosome, centromeric region IEA --
GO:0000793 colocalizes_with condensed chromosome IEA,IDA 27362226
GO:0005634 nucleus IEA,IDA 22378020
GO:0005694 chromosome IEA --
GO:0005730 nucleolus IEA,IDA 17577209
genes like me logo Genes that share ontologies with MKI67: view

Pathways & Interactions for MKI67 Gene

genes like me logo Genes that share pathways with MKI67: view

Pathways by source for MKI67 Gene

2 Cell Signaling Technology pathways for MKI67 Gene
1 BioSystems pathway for MKI67 Gene

Gene Ontology (GO) - Biological Process for MKI67 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006259 DNA metabolic process IEA --
GO:0007049 cell cycle IEA --
GO:0007088 regulation of mitotic nuclear division IDA 27362226
GO:0007126 meiotic nuclear division IEA --
GO:0008283 cell proliferation TAS 17577209
genes like me logo Genes that share ontologies with MKI67: view

No data available for SIGNOR curated interactions for MKI67 Gene

Drugs & Compounds for MKI67 Gene

(48) Drugs for MKI67 Gene - From: PharmGKB and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Fulvestrant Approved, Investigational Pharma Antagonist Estrogen receptor antagonist,high affinity, Hormone therapy 194

(34) Additional Compounds for MKI67 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with MKI67: view

Transcripts for MKI67 Gene

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for MKI67

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for MKI67 Gene

ExUns: 1 ^ 2a · 2b ^ 3 ^ 4 ^ 5 ^ 6 ^ 7a · 7b ^ 8a · 8b ^ 9 ^ 10a · 10b ^ 11 ^ 12 ^ 13a · 13b ^ 14 ^ 15a · 15b ^ 16a · 16b · 16c ^ 17
SP1: - - - - - - -
SP2:
SP3:
SP4:
SP5:
SP6:
SP7: -
SP8: -

Relevant External Links for MKI67 Gene

GeneLoc Exon Structure for
MKI67
ECgene alternative splicing isoforms for
MKI67

Expression for MKI67 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for MKI67 Gene

mRNA differential expression in normal tissues according to GTEx for MKI67 Gene

This gene is overexpressed in Esophagus - Mucosa (x4.3).

Protein differential expression in normal tissues from HIPED for MKI67 Gene

This gene is overexpressed in Placenta (20.3), Kidney (13.4), Fetal testis (8.5), Liver (7.5), and Esophagus (6.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for MKI67 Gene



NURSA nuclear receptor signaling pathways regulating expression of MKI67 Gene:

MKI67

SOURCE GeneReport for Unigene cluster for MKI67 Gene:

Hs.80976
genes like me logo Genes that share expression patterns with MKI67: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein tissue co-expression partners and mRNA Expression by UniProt/SwissProt for MKI67 Gene

Orthologs for MKI67 Gene

This gene was present in the common ancestor of chordates.

Orthologs for MKI67 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia MKI67 34 35
  • 98.9 (n)
dog
(Canis familiaris)
Mammalia MKI67 34 35
  • 68.91 (n)
cow
(Bos Taurus)
Mammalia MKI67 34 35
  • 65.49 (n)
rat
(Rattus norvegicus)
Mammalia Mki67 34
  • 64.34 (n)
mouse
(Mus musculus)
Mammalia Mki67 34 16 35
  • 63.29 (n)
oppossum
(Monodelphis domestica)
Mammalia MKI67 35
  • 22 (a)
OneToOne
chicken
(Gallus gallus)
Aves MKI67 35
  • 16 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia MKI67 35
  • 24 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.6364 34
zebrafish
(Danio rerio)
Actinopterygii mki67 35
  • 18 (a)
OneToOne
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 34 (a)
OneToOne
Species where no ortholog for MKI67 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for MKI67 Gene

ENSEMBL:
Gene Tree for MKI67 (if available)
TreeFam:
Gene Tree for MKI67 (if available)

Paralogs for MKI67 Gene

Pseudogenes.org Pseudogenes for MKI67 Gene

genes like me logo Genes that share paralogs with MKI67: view

No data available for Paralogs for MKI67 Gene

Variants for MKI67 Gene

Sequence variations from dbSNP and Humsavar for MKI67 Gene

SNP ID Clin Chr 10 pos Sequence Context AA Info Type
rs796052184 Likely benign 128,104,734(-) AGACG(C/T)AGAGG reference, missense
rs10082391 -- 128,103,561(+) CTTTA(C/T)CTTCA reference, missense
rs10082432 -- 128,103,458(+) GCTTG(A/G)GCACT reference, synonymous-codon
rs10082504 -- 128,101,279(+) GCACA(C/T)CTCTT reference, synonymous-codon
rs10082533 -- 128,103,462(+) GGGCA(C/T)TTTCC reference, missense

Structural Variations from Database of Genomic Variants (DGV) for MKI67 Gene

Variant ID Type Subtype PubMed ID
dgv52n21 CNV loss 19592680
dgv989n100 CNV gain 25217958
esv2660735 CNV deletion 23128226
esv2676916 CNV deletion 23128226
esv34105 CNV loss 18971310
esv3624896 CNV loss 21293372
nsv467481 CNV loss 19166990
nsv523484 CNV loss 19592680
nsv552312 CNV loss 21841781
nsv552313 CNV loss 21841781

Variation tolerance for MKI67 Gene

Residual Variation Intolerance Score: 99.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 25.13; 99.69% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for MKI67 Gene

Human Gene Mutation Database (HGMD)
MKI67
SNPedia medical, phenotypic, and genealogical associations of SNPs for
MKI67

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MKI67 Gene

Disorders for MKI67 Gene

MalaCards: The human disease database

(50) MalaCards diseases for MKI67 Gene - From: DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
cervical intraepithelial neoplasia
  • cin
pancreatic neuroendocrine tumor
  • islet cell tumor
bowen's disease
  • bowens disease
ameloblastic carcinoma
uterus leiomyosarcoma
  • leiomyosarcoma of corpus uteri
- elite association - COSMIC cancer census association via MalaCards
Search MKI67 in MalaCards View complete list of genes associated with diseases

Relevant External Links for MKI67

Genetic Association Database (GAD)
MKI67
Human Genome Epidemiology (HuGE) Navigator
MKI67
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
MKI67
genes like me logo Genes that share disorders with MKI67: view

No data available for UniProtKB/Swiss-Prot and Genatlas for MKI67 Gene

Publications for MKI67 Gene

  1. Ki-67 acts as a biological surfactant to disperse mitotic chromosomes. (PMID: 27362226) Cuylen S. … Gerlich D.W. (Nature 2016) 3 4 64
  2. Ki-67 is a PP1-interacting protein that organises the mitotic chromosome periphery. (PMID: 24867636) Booth D.G. … Vagnarelli P. (Elife 2014) 3 4 64
  3. MIB-1 (Ki-67), estrogen receptor, progesterone receptor, and p53 expression in atypical cells in uterine symplastic leiomyomas. (PMID: 19952937) Sun X. … Mittal K. (Int. J. Gynecol. Pathol. 2010) 3 22 64
  4. [Prognostic value of of the expression Ki-67, CD31, and VEGF in somatotropinomas]. (PMID: 20369584) Przhiialkovskaia E.G. … Rozhinskaia L.I.a. (Arkh. Patol. 2010) 3 22 64
  5. Evaluation of candidate stromal epithelial cross-talk genes identifies association between risk of serous ovarian cancer and TERT, a cancer susceptibility "hot-spot". (PMID: 20628624) Johnatty S.E. … . (PLoS Genet. 2010) 3 46 64

Products for MKI67 Gene

Sources for MKI67 Gene

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