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Aliases for MKI67 Gene

Aliases for MKI67 Gene

  • Marker Of Proliferation Ki-67 2 3 5
  • Antigen Identified By Monoclonal Antibody Ki-67 2 3
  • Protein Phosphatase 1, Regulatory Subunit 105 3
  • Proliferation-Related Ki-67 Antigen 3
  • Regulatory Subunit 105 2
  • Protein Phosphatase 1 2
  • PPP1R105 3
  • MIB-1 3
  • MIB- 3
  • KIA 3

External Ids for MKI67 Gene

Previous GeneCards Identifiers for MKI67 Gene

  • GC10M128707
  • GC10M128936
  • GC10M129824
  • GC10M129369
  • GC10M129784
  • GC10M123469
  • GC10M129894

Summaries for MKI67 Gene

Entrez Gene Summary for MKI67 Gene

  • This gene encodes a nuclear protein that is associated with and may be necessary for cellular proliferation. Alternatively spliced transcript variants have been described. A related pseudogene exists on chromosome X. [provided by RefSeq, Mar 2009]

GeneCards Summary for MKI67 Gene

MKI67 (Marker Of Proliferation Ki-67) is a Protein Coding gene. Diseases associated with MKI67 include uterus leiomyosarcoma and ovarian stromal hyperthecosis. GO annotations related to this gene include poly(A) RNA binding and protein C-terminus binding.

UniProtKB/Swiss-Prot for MKI67 Gene

  • Thought to be required for maintaining cell proliferation.

Gene Wiki entry for MKI67 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MKI67 Gene

Genomics for MKI67 Gene

Regulatory Elements for MKI67 Gene

Promoters for MKI67 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around MKI67 on UCSC Golden Path with GeneCards custom track

Genomic Location for MKI67 Gene

Chromosome:
10
Start:
128,096,659 bp from pter
End:
128,126,385 bp from pter
Size:
29,727 bases
Orientation:
Minus strand

Genomic View for MKI67 Gene

Genes around MKI67 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MKI67 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MKI67 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MKI67 Gene

Proteins for MKI67 Gene

  • Protein details for MKI67 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P46013-KI67_HUMAN
    Recommended name:
    Antigen KI-67
    Protein Accession:
    P46013
    Secondary Accessions:
    • Q5VWH2

    Protein attributes for MKI67 Gene

    Size:
    3256 amino acids
    Molecular mass:
    358694 Da
    Quaternary structure:
    • Interacts with KIF15. Binds through the FHA domain to NIFK. Part of a complex composed at least of ASCL2, EMSY, HCFC1, HSPA8, CCAR2, MATR3, MKI67, RBBP5, TUBB2A, WDR5 and ZNF335; this complex may have a histone H3-specific methyltransferase activity.

    Three dimensional structures from OCA and Proteopedia for MKI67 Gene

    Alternative splice isoforms for MKI67 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for MKI67 Gene

Proteomics data for MKI67 Gene at MOPED

Post-translational modifications for MKI67 Gene

  • Ubiquitination at Lys 659, Lys 666, Lys 745, Lys 1043, Lys 1549, Lys 1592, Lys 2138, and Lys 2289
  • Modification sites at PhosphoSitePlus

Other Protein References for MKI67 Gene

Antibody Products

  • Cell Signaling Technology (CST) Antibodies for MKI67 (KI-67)

No data available for DME Specific Peptides for MKI67 Gene

Domains & Families for MKI67 Gene

Gene Families for MKI67 Gene

Protein Domains for MKI67 Gene

Suggested Antigen Peptide Sequences for MKI67 Gene

Graphical View of Domain Structure for InterPro Entry

P46013

UniProtKB/Swiss-Prot:

KI67_HUMAN :
  • Contains 1 FHA domain.
Domain:
  • Contains 1 FHA domain.
genes like me logo Genes that share domains with MKI67: view

Function for MKI67 Gene

Molecular function for MKI67 Gene

GENATLAS Biochemistry:
antigen identified by monoclonal antibody Ki-67 (non histone protein 395/345kDa)
UniProtKB/Swiss-Prot Function:
Thought to be required for maintaining cell proliferation.

Gene Ontology (GO) - Molecular Function for MKI67 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IEA,IPI 11342549
genes like me logo Genes that share ontologies with MKI67: view
genes like me logo Genes that share phenotypes with MKI67: view

Animal Model Products

miRNA for MKI67 Gene

miRTarBase miRNAs that target MKI67

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for MKI67 Gene

Localization for MKI67 Gene

Subcellular locations from UniProtKB/Swiss-Prot for MKI67 Gene

Nucleus. Nucleus, nucleolus. Chromosome. Note=Predominantly localized in the G1 phase in the perinucleolar region, in the later phases it is also detected throughout the nuclear interior, being predominantly localized in the nuclear matrix. In mitosis, it is present on all chromosomes.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for MKI67 Gene COMPARTMENTS Subcellular localization image for MKI67 gene
Compartment Confidence
nucleus 5
cytoskeleton 2
mitochondrion 2
cytosol 1
extracellular 1
plasma membrane 1

Gene Ontology (GO) - Cellular Components for MKI67 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016020 membrane IDA 19946888
genes like me logo Genes that share ontologies with MKI67: view

Pathways & Interactions for MKI67 Gene

SuperPathways for MKI67 Gene

No Data Available

Gene Ontology (GO) - Biological Process for MKI67 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0072574 hepatocyte proliferation IEA --
GO:1990705 cholangiocyte proliferation IEA --
genes like me logo Genes that share ontologies with MKI67: view

No data available for Pathways by source and SIGNOR curated interactions for MKI67 Gene

Drugs & Compounds for MKI67 Gene

(46) Drugs for MKI67 Gene - From: Novoseek and PharmGKB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Fulvestrant Approved, Investigational Pharma Antagonist Estrogen receptor antagonist,high affinity, Hormone therapy 173

(36) Additional Compounds for MKI67 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with MKI67: view

Transcripts for MKI67 Gene

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for MKI67 Gene

ExUns: 1 ^ 2a · 2b ^ 3 ^ 4 ^ 5 ^ 6 ^ 7a · 7b ^ 8a · 8b ^ 9 ^ 10a · 10b ^ 11 ^ 12 ^ 13a · 13b ^ 14 ^ 15a · 15b ^ 16a · 16b · 16c ^ 17
SP1: - - - - - - -
SP2:
SP3:
SP4:
SP5:
SP6:
SP7: -
SP8: -

Relevant External Links for MKI67 Gene

GeneLoc Exon Structure for
MKI67
ECgene alternative splicing isoforms for
MKI67

Expression for MKI67 Gene

mRNA expression in normal human tissues for MKI67 Gene

mRNA differential expression in normal tissues according to GTEx for MKI67 Gene

This gene is overexpressed in Esophagus - Mucosa (x4.3).

Protein differential expression in normal tissues from HIPED for MKI67 Gene

This gene is overexpressed in Placenta (20.3), Kidney (13.4), Fetal testis (8.5), Liver (7.5), and Esophagus (6.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for MKI67 Gene



SOURCE GeneReport for Unigene cluster for MKI67 Gene Hs.80976

genes like me logo Genes that share expression patterns with MKI67: view

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA Expression by UniProt/SwissProt and Protein tissue co-expression partners for MKI67 Gene

Orthologs for MKI67 Gene

This gene was present in the common ancestor of chordates.

Orthologs for MKI67 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia MKI67 36
  • 98 (a)
OneToOne
MKI67 35
  • 98.9 (n)
  • 97.97 (a)
cow
(Bos Taurus)
Mammalia MKI67 35
  • 65.49 (n)
  • 48.24 (a)
MKI67 36
  • 43 (a)
OneToOne
dog
(Canis familiaris)
Mammalia MKI67 36
  • 48 (a)
OneToOne
MKI67 35
  • 68.91 (n)
  • 53.64 (a)
mouse
(Mus musculus)
Mammalia Mki67 16
Mki67 36
  • 41 (a)
OneToOne
Mki67 35
  • 63.29 (n)
  • 46.5 (a)
oppossum
(Monodelphis domestica)
Mammalia MKI67 36
  • 22 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Mki67 35
  • 64.34 (n)
  • 47.51 (a)
chicken
(Gallus gallus)
Aves MKI67 36
  • 16 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia MKI67 36
  • 24 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.6364 35
zebrafish
(Danio rerio)
Actinopterygii mki67 36
  • 18 (a)
OneToOne
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 34 (a)
OneToOne
Species with no ortholog for MKI67:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for MKI67 Gene

ENSEMBL:
Gene Tree for MKI67 (if available)
TreeFam:
Gene Tree for MKI67 (if available)

Paralogs for MKI67 Gene

Pseudogenes.org Pseudogenes for MKI67 Gene

genes like me logo Genes that share paralogs with MKI67: view

No data available for Paralogs for MKI67 Gene

Variants for MKI67 Gene

Sequence variations from dbSNP and Humsavar for MKI67 Gene

SNP ID Clin Chr 10 pos Sequence Context AA Info Type
rs11106 - 128,101,514(-) AGTCA(C/G)TGAGA reference, missense
rs8473 - 128,101,314(-) AGAGC(A/G)AATCT reference, missense
rs3740423 - 128,107,632(+) AGAGC(A/T)CCTTC reference, missense
rs4750685 - 128,108,100(+) TTTTA(A/G)TGGTT reference, missense
rs997983 - 128,112,211(-) TGTCT(A/C)TCAGC upstream-variant-2KB, reference, missense

Structural Variations from Database of Genomic Variants (DGV) for MKI67 Gene

Variant ID Type Subtype PubMed ID
esv34105 CNV Loss 18971310
nsv467481 CNV Loss 19166990
dgv52n21 CNV Loss 19592680
nsv523484 CNV Loss 19592680
esv2676916 CNV Deletion 23128226
esv2660735 CNV Deletion 23128226
esv2743339 CNV Deletion 23290073

Variation tolerance for MKI67 Gene

Residual Variation Intolerance Score: 99.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 25.13; 99.69% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for MKI67 Gene

HapMap Linkage Disequilibrium report
MKI67
Human Gene Mutation Database (HGMD)
MKI67

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MKI67 Gene

Disorders for MKI67 Gene

MalaCards: The human disease database

(67) MalaCards diseases for MKI67 Gene - From: DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
uterus leiomyosarcoma
  • leiomyosarcoma of corpus uteri
ovarian stromal hyperthecosis
brain ependymoma
  • ependymal tumor of brain
central neurocytoma
  • neurolipocytoma
acinar cell cystadenocarcinoma
  • pancreatic acinar cell cystadenocarcinoma
- elite association - COSMIC cancer census association via MalaCards
Search MKI67 in MalaCards View complete list of genes associated with diseases

Relevant External Links for MKI67

Genetic Association Database (GAD)
MKI67
Human Genome Epidemiology (HuGE) Navigator
MKI67
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
MKI67
genes like me logo Genes that share disorders with MKI67: view

No data available for UniProtKB/Swiss-Prot and Genatlas for MKI67 Gene

Publications for MKI67 Gene

  1. Evaluation of candidate stromal epithelial cross-talk genes identifies association between risk of serous ovarian cancer and TERT, a cancer susceptibility "hot-spot". (PMID: 20628624) Johnatty S.E. … . (PLoS Genet. 2010) 3 48 67
  2. Immunohistochemical overexpression of the p53 protein and Ki-67 (MIB-1) antigen in patients with GERD and chronic esophagitis. (PMID: 20414055) Binato M. … Edelweiss M.I. (Appl. Immunohistochem. Mol. Morphol. 2010) 3 23
  3. [Prognostic value of of the expression Ki-67, CD31, and VEGF in somatotropinomas]. (PMID: 20369584) Przhiialkovskaia E.G. … Rozhinskaia L.I.a. (Arkh. Patol. 2010) 3 23
  4. MIB-1 (Ki-67), estrogen receptor, progesterone receptor, and p53 expression in atypical cells in uterine symplastic leiomyomas. (PMID: 19952937) Sun X. … Mittal K. (Int. J. Gynecol. Pathol. 2010) 3 23
  5. Steroid receptors, HER2/neu and Ki-67, in endometrioid type of endometrial carcinoma: Correlation with conventional histomorphological features of prognosis. (PMID: 19446313) Chakravarty D. … Dhaliwal L. (Acta Histochem. 2010) 3 23

Products for MKI67 Gene

Sources for MKI67 Gene

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