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Aliases for MKI67 Gene

Aliases for MKI67 Gene

  • Marker Of Proliferation Ki-67 2 3
  • Antigen Identified By Monoclonal Antibody Ki-67 2 3
  • Protein Phosphatase 1, Regulatory Subunit 105 3
  • Proliferation-Related Ki-67 Antigen 3
  • Regulatory Subunit 105 2
  • Protein Phosphatase 1 2
  • Antigen KI-67 3
  • PPP1R105 3
  • MIB-1 3
  • MIB- 3
  • KIA 3

External Ids for MKI67 Gene

Previous GeneCards Identifiers for MKI67 Gene

  • GC10M128707
  • GC10M128936
  • GC10M129824
  • GC10M129369
  • GC10M129784
  • GC10M123469
  • GC10M129894

Summaries for MKI67 Gene

Entrez Gene Summary for MKI67 Gene

  • This gene encodes a nuclear protein that is associated with and may be necessary for cellular proliferation. Alternatively spliced transcript variants have been described. A related pseudogene exists on chromosome X. [provided by RefSeq, Mar 2009]

GeneCards Summary for MKI67 Gene

MKI67 (Marker Of Proliferation Ki-67) is a Protein Coding gene. Diseases associated with MKI67 include sebaceous adenoma and necrotizing sialometaplasia. Among its related pathways are Cell Cycle / Checkpoint Control and Neuroscience. GO annotations related to this gene include protein C-terminus binding.

UniProtKB/Swiss-Prot for MKI67 Gene

  • Thought to be required for maintaining cell proliferation

Gene Wiki entry for MKI67 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MKI67 Gene

Genomics for MKI67 Gene

Regulatory Elements for MKI67 Gene

Genomic Location for MKI67 Gene

Start:
128,096,659 bp from pter
End:
128,126,385 bp from pter
Size:
29,727 bases
Orientation:
Minus strand

Genomic View for MKI67 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for MKI67 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MKI67 Gene

Proteins for MKI67 Gene

  • Protein details for MKI67 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P46013-KI67_HUMAN
    Recommended name:
    Antigen KI-67
    Protein Accession:
    P46013
    Secondary Accessions:
    • Q5VWH2

    Protein attributes for MKI67 Gene

    Size:
    3256 amino acids
    Molecular mass:
    358694 Da
    Quaternary structure:
    • Interacts with KIF15. Binds through the FHA domain to NIFK. Part of a complex composed at least of ASCL2, C11orf30/EMSY, HCFC1, HSPA8, CCAR2, MATR3, MKI67, RBBP5, TUBB2A, WDR5 and ZNF335; this complex may have a histone H3-specific methyltransferase activity.

    Three dimensional structures from OCA and Proteopedia for MKI67 Gene

    Alternative splice isoforms for MKI67 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for MKI67 Gene

Proteomics data for MKI67 Gene at MOPED

Post-translational modifications for MKI67 Gene

  • Ubiquitination at Lys659, Lys666, Lys745, Lys1043, Lys1549, Lys1592, Lys2138, and Lys2289
  • Modification sites at PhosphoSitePlus

Other Protein References for MKI67 Gene

No data available for DME Specific Peptides for MKI67 Gene

Domains for MKI67 Gene

Protein Domains for MKI67 Gene

Suggested Antigen Peptide Sequences for MKI67 Gene

Graphical View of Domain Structure for InterPro Entry

P46013

UniProtKB/Swiss-Prot:

KI67_HUMAN :
  • P46013
Domain:
  • Contains 1 FHA domain.
genes like me logo Genes that share domains with MKI67: view

No data available for Gene Families for MKI67 Gene

Function for MKI67 Gene

Molecular function for MKI67 Gene

GENATLAS Biochemistry: antigen identified by monoclonal antibody Ki-67 (non histone protein 395/345kDa)
UniProtKB/Swiss-Prot Function: Thought to be required for maintaining cell proliferation

Gene Ontology (GO) - Molecular Function for MKI67 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 11342549
GO:0005524 ATP binding IEA --
GO:0008022 protein C-terminus binding IPI 17577209
GO:0044822 poly(A) RNA binding IDA 22658674
genes like me logo Genes that share ontologies with MKI67: view
genes like me logo Genes that share phenotypes with MKI67: view

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for MKI67 Gene

Localization for MKI67 Gene

Subcellular locations from UniProtKB/Swiss-Prot for MKI67 Gene

Nucleus. Nucleus, nucleolus. Chromosome. Note=Predominantly localized in the G1 phase in the perinucleolar region, in the later phases it is also detected throughout the nuclear interior, being predominantly localized in the nuclear matrix. In mitosis, it is present on all chromosomes.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for MKI67 Gene COMPARTMENTS Subcellular localization image for MKI67 gene
Compartment Confidence
nucleus 5
cytoskeleton 2
extracellular 2
mitochondrion 2
cytosol 1

Gene Ontology (GO) - Cellular Components for MKI67 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000775 chromosome, centromeric region IEA --
GO:0000793 condensed chromosome IEA --
GO:0005634 nucleus IDA --
GO:0005730 nucleolus IDA --
GO:0005737 cytoplasm IEA --
genes like me logo Genes that share ontologies with MKI67: view

Pathways for MKI67 Gene

genes like me logo Genes that share pathways with MKI67: view

Pathways by source for MKI67 Gene

2 Cell Signaling Technology pathways for MKI67 Gene

Gene Ontology (GO) - Biological Process for MKI67 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007126 meiotic nuclear division IEA --
GO:0008283 cell proliferation TAS 17577209
genes like me logo Genes that share ontologies with MKI67: view

Compounds for MKI67 Gene

(81) Novoseek inferred chemical compound relationships for MKI67 Gene

Compound -log(P) Hits PubMed IDs
paraffin 77.8 99
progesterone 68.2 116
estrogen 62.6 114
bromodeoxyuridine 48.4 43
hematoxylin 47.7 11

(1) PharmGKB related drug/compound annotations for MKI67 Gene

Drug/compound Annotation
fulvestrant
genes like me logo Genes that share compounds with MKI67: view

Transcripts for MKI67 Gene

Alternative Splicing Database (ASD) splice patterns (SP) for MKI67 Gene

ExUns: 1 ^ 2a · 2b ^ 3 ^ 4 ^ 5 ^ 6 ^ 7a · 7b ^ 8a · 8b ^ 9 ^ 10a · 10b ^ 11 ^ 12 ^ 13a · 13b ^ 14 ^ 15a · 15b ^ 16a · 16b · 16c ^ 17
SP1: - - - - - - -
SP2:
SP3:
SP4:
SP5:
SP6:
SP7: -
SP8: -

Relevant External Links for MKI67 Gene

GeneLoc Exon Structure for
MKI67
ECgene alternative splicing isoforms for
MKI67

Expression for MKI67 Gene

mRNA expression in normal human tissues for MKI67 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for MKI67 Gene

This gene is overexpressed in Esophagus - Mucosa (4.3).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for MKI67 Gene

SOURCE GeneReport for Unigene cluster for MKI67 Gene Hs.80976

genes like me logo Genes that share expressions with MKI67: view

No data available for mRNA Expression by UniProt/SwissProt for MKI67 Gene

Orthologs for MKI67 Gene

This gene was present in the common ancestor of chordates.

Orthologs for MKI67 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia MKI67 35
  • 98.9 (n)
  • 97.97 (a)
MKI67 36
  • 98 (a)
OneToOne
cow
(Bos Taurus)
Mammalia MKI67 35
  • 65.49 (n)
  • 48.24 (a)
MKI67 36
  • 43 (a)
OneToOne
dog
(Canis familiaris)
Mammalia MKI67 35
  • 68.91 (n)
  • 53.64 (a)
MKI67 36
  • 48 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Mki67 35
  • 63.29 (n)
  • 46.5 (a)
Mki67 16
Mki67 36
  • 41 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia MKI67 36
  • 22 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Mki67 35
  • 64.34 (n)
  • 47.51 (a)
chicken
(Gallus gallus)
Aves MKI67 36
  • 16 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia MKI67 36
  • 24 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.6364 35
zebrafish
(Danio rerio)
Actinopterygii mki67 36
  • 18 (a)
OneToOne
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 34 (a)
OneToOne
Species with no ortholog for MKI67:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for MKI67 Gene

ENSEMBL:
Gene Tree for MKI67 (if available)
TreeFam:
Gene Tree for MKI67 (if available)

Paralogs for MKI67 Gene

Pseudogenes.org Pseudogenes for MKI67 Gene

genes like me logo Genes that share paralogs with MKI67: view

No data available for Paralogs for MKI67 Gene

Variants for MKI67 Gene

Sequence variations from dbSNP and Humsavar for MKI67 Gene

SNP ID Clin Chr 10 pos Sequence Context AA Info Type MAF
rs2240 - 128,109,280(+) CTCCA(C/G)AGAAG reference, missense
rs7347 -- 128,097,968(-) TGCCC(C/T)GTCTC utr-variant-3-prime
rs7348 -- 128,096,734(-) GACTG(C/T)ATTTC utr-variant-3-prime
rs8436 -- 128,096,719(-) TTACT(C/G)TATCC utr-variant-3-prime
rs8473 - 128,101,314(-) AGAGC(A/G)AATCT reference, missense

Structural Variations from Database of Genomic Variants (DGV) for MKI67 Gene

Variant ID Type Subtype PubMed ID
esv34105 CNV Loss 18971310
nsv467481 CNV Loss 19166990
dgv52n21 CNV Loss 19592680
nsv523484 CNV Loss 19592680
esv2676916 CNV Deletion 23128226
esv2660735 CNV Deletion 23128226
esv2743339 CNV Deletion 23290073

Relevant External Links for MKI67 Gene

HapMap Linkage Disequilibrium report
MKI67
Human Gene Mutation Database (HGMD)
MKI67

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MKI67 Gene

Disorders for MKI67 Gene

(3) University of Copenhagen DISEASES for MKI67 Gene

(98) Novoseek inferred disease relationships for MKI67 Gene

Disease -log(P) Hits PubMed IDs
carcinoma 77.5 138
tumors 76.5 236
dysplasia 71.2 104
metastasis 69.2 101
adenoma 68.5 86

Relevant External Links for MKI67

Genetic Association Database (GAD)
MKI67
Human Genome Epidemiology (HuGE) Navigator
MKI67
genes like me logo Genes that share disorders with MKI67: view

No data available for UniProtKB/Swiss-Prot for MKI67 Gene

Publications for MKI67 Gene

  1. Molecular characterization of the gene locus of the human cell proliferation-associated nuclear protein defined by monoclonal antibody Ki-67. (PMID: 8603106) Duchrow M. … Gerdes J. (Cell Prolif. 1996) 3 23
  2. Immunohistochemical study of the proliferation index, oestrogen receptors and progesterone receptors A and B in leiomyomata and normal myometrium during the menstrual cycle and under gonadotrophin-releasing hormone agonist therapy. (PMID: 10548634) Nisolle M. … Donnez J. (Hum. Reprod. 1999) 3 23
  3. The abnormal expression of retinoic acid receptor-beta, p 53 and Ki67 protein in normal, premalignant and malignant esophageal tissues. (PMID: 11925591) Xu M. … Zhang W. (World J. Gastroenterol. 2002) 3 23
  4. Retrospective analysis of Ki-67 antigen expression in paraffin tissue blocks of laryngeal squamous cell carcinoma. (PMID: 12649825) Fumic-Dunkic L. … Vcev A. (Am J Otolaryngol 2003) 3 23
  5. [Comparative studies of K1-67 expression between the primary tumor and breast cancer metastases to regional lymph nodes]. (PMID: 14674120) Koda M. … Sulkowski S. (Ginekol. Pol. 2003) 3 23

Products for MKI67 Gene

  • antibodies-online proteins for MKI67
  • antibodies-online antibodies for MKI67
  • antibodies-online kits for MKI67

Sources for MKI67 Gene

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