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MKI67 Gene

protein-coding   GIFtS: 64
GCID: GC10M129894

Marker Of Proliferation Ki-67

(Previous name: antigen identified by monoclonal antibody Ki-67)
Microbiology & Infectious Diseases Congress
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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Marker Of Proliferation Ki-671 2
Antigen Identified By Monoclonal Antibody Ki-671 2
KIA2
MIB-12
Antigen KI-672
Proliferation-Related Ki-67 Antigen2

External Ids:    HGNC: 71071   Entrez Gene: 42882   Ensembl: ENSG000001487737   OMIM: 1767415   UniProtKB: P460133   

Export aliases for MKI67 gene to outside databases

Previous GC identifers: GC10M128707 GC10M128936 GC10M129824 GC10M129369 GC10M129784 GC10M123469


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for MKI67 Gene:
This gene encodes a nuclear protein that is associated with and may be necessary for cellular proliferation.
Alternatively spliced transcript variants have been described. A related pseudogene exists on chromosome X.
(provided by RefSeq, Mar 2009)

GeneCards Summary for MKI67 Gene:
MKI67 (marker of proliferation Ki-67) is a protein-coding gene. Diseases associated with MKI67 include ovarian stromal hyperthecosis, and brain ependymoma. GO annotations related to this gene include protein C-terminus binding.

UniProtKB/Swiss-Prot: KI67_HUMAN, P46013
Function: Thought to be required for maintaining cell proliferation

Gene Wiki entry for MKI67 (Ki-67) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000010.11  NT_030059.14  NC_018921.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the MKI67 gene promoter:
         CHOP-10   TBP   Cart-1   CUTL1   Gfi-1   Evi-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidMKI67 promoter sequence
   Search Chromatin IP Primers for MKI67

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat MKI67


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 10q26.2   Ensembl cytogenetic band:  10q26.2   HGNC cytogenetic band: 10q26.2

MKI67 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
MKI67 gene location

GeneLoc information about chromosome 10         GeneLoc Exon Structure

GeneLoc location for GC10M129894:  view genomic region     (about GC identifiers)

Start:
129,894,923 bp from pter      End:
129,924,649 bp from pter
Size:
29,727 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: KI67_HUMAN, P46013 (See protein sequence)
Recommended Name: Antigen KI-67  
Size: 3256 amino acids; 358694 Da
Subunit: Interacts with KIF15. Binds through the FHA domain to NIFK. Part of a complex composed at least of ASCL2,
C11orf30/EMSY, HCFC1, HSPA8, CCAR2, MATR3, MKI67, RBBP5, TUBB2A, WDR5 and ZNF335; this complex may have a histone
H3-specific methyltransferase activity
Developmental stage: Expression of this antigen occurs preferentially during late G1, S, G2 and M phases of the
cell cycle, while in cells in G0 phase the antigen cannot be detected
2 PDB 3D structures from and Proteopedia for MKI67:
1R21 (3D)        2AFF (3D)    
Secondary accessions: Q5VWH2
Alternative splicing: 2 isoforms:  P46013-1   P46013-2   

Explore the universe of human proteins at neXtProt for MKI67: NX_P46013

Explore proteomics data for MKI67 at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys659, Lys666, Lys745, Lys1043, Lys1549, Lys1592, Lys2138, Lys2289
  • Modification sites at PhosphoSitePlus

  • See MKI67 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_001139438.1  NP_002408.3  

    ENSEMBL proteins: 
     ENSP00000357642   ENSP00000357643  

    MKI67 Human Recombinant Protein Products:

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    Browse Proteins at Cloud-Clone Corp.

    MKI67 Antibody Products:

    EMD Millipore Mono- and Polyclonal Antibodies for the study of MKI67
    R&D Systems Antibodies for MKI67 (Ki-67/MKI67)
    Cell Signaling Technology (CST) Antibodies for MKI67  (KI-67)
    OriGene Antibodies for MKI67
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    Novus Biologicals MKI67 Antibodies
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    ThermoFisher Antibody for MKI67
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    MKI67 Assay Products:

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    GenScript Custom Assay Services for MKI67
    Browse Enzo Life Sciences for kits & assays
    Browse ELISAs at Cloud-Clone Corp.
    Browse CLIAs at Cloud-Clone Corp.


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    3 InterPro protein domains:
     IPR008984 SMAD_FHA_domain
     IPR012568 K167R
     IPR000253 FHA_dom

    Graphical View of Domain Structure for InterPro Entry P46013

    ProtoNet protein and cluster: P46013

    2 Blocks protein domains:
    IPB000253 Forkhead-associated (FHA)
    IPB012568 K167R


    UniProtKB/Swiss-Prot: KI67_HUMAN, P46013
    Similarity: Contains 1 FHA domain


    MKI67 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: KI67_HUMAN, P46013
    Function: Thought to be required for maintaining cell proliferation

         Genatlas biochemistry entry for MKI67:
    antigen identified by monoclonal antibody Ki-67 (non histone protein 395/345kDa)

         Gene Ontology (GO): 4 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding IPI11342549
    GO:0005524ATP binding IEA--
    GO:0008022protein C-terminus binding IPI17577209
    GO:0044822poly(A) RNA binding IDA--
         
    MKI67 for ontologies           About GeneDecksing


    Phenotypes:
         3 GenomeRNAi human phenotypes for MKI67:
     Increased cell death in breast  Synthetic lethal with Ras  Upregulation of Wnt/beta-caten 

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for MKI67
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       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for MKI67
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for MKI67

    miRNA
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    miRTarBase miRNAs that target MKI67:
    hsa-mir-221-3p (MIRT046919), hsa-mir-29b-3p (MIRT048383), hsa-mir-1 (MIRT023674), hsa-mir-505-3p (MIRT041044), hsa-mir-34a-5p (MIRT025361), hsa-mir-331-3p (MIRT043477), hsa-mir-1296-5p (MIRT036119), hsa-mir-484 (MIRT041876), hsa-mir-92a-3p (MIRT049015), hsa-mir-17-5p (MIRT051037), hsa-mir-877-3p (MIRT037098), hsa-mir-16-5p (MIRT031529), hsa-mir-1909-5p (MIRT035804), hsa-mir-328-3p (MIRT043812), hsa-let-7e-5p (MIRT051657), hsa-mir-215-5p (MIRT024267), hsa-mir-615-3p (MIRT040461), hsa-mir-192-5p (MIRT026336)

    Block miRNA regulation of human, mouse, rat MKI67 using miScript Target Protectors
    Search for qRT-PCR Assays for microRNAs that regulate MKI67
    SwitchGear 3'UTR luciferase reporter plasmidMKI67 3' UTR sequence
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    Sino Biological Human cDNA Clone for MKI67
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MKI67


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    KI67_HUMAN, P46013: Nucleus. Nucleus, nucleolus. Chromosome. Note=Predominantly localized in the G1 phase in the
    perinucleolar region, in the later phases it is also detected throughout the nuclear interior, being
    predominantly localized in the nuclear matrix. In mitosis, it is present on all chromosomes
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus5
    cytoskeleton2
    extracellular2
    mitochondrion2
    cytosol1

    Gene Ontology (GO): Selected cellular component terms (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000775chromosome, centromeric region IEA--
    GO:0000793condensed chromosome IEA--
    GO:0005622intracellular ----
    GO:0005634nucleus IDA--
    GO:0005730nucleolus IDA--

    MKI67 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for MKI67 About                                                                                                See pathways by source

    SuperPathContained pathways About
    1Cell Cycle / Checkpoint Control
    Cell Cycle / Checkpoint Control0.32
    2Neuroscience
    Neuroscience

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    2 Cell Signaling Technology (CST) Pathways for MKI67
        Cell Cycle / Checkpoint Control
    Neuroscience




    MKI67 for pathways           About GeneDecksing

        Pathway & Disease-focused RT2 Profiler PCR Arrays including MKI67 (see all 7): 
              Lung Cancer in human mouse rat
              Cell Cycle in human mouse rat
              Breast Cancer in human mouse rat
              Cancer PathwayFinder in human mouse rat
              Lymphoma in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for MKI67

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for MKI67 (P460132, 3 ENSP000003576434) via UniProtKB, MINT, STRING, and/or I2D (see all 60)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    KIF15Q9NS872, 3, ENSP000003240204MINT-14343 MINT-14342 I2D: score=3 STRING: ENSP00000324020
    ABL1P005192, 3, ENSP000003614234MINT-8110467 I2D: score=3 STRING: ENSP00000361423
    FYNP062412, 3, ENSP000003576564MINT-8111319 I2D: score=3 STRING: ENSP00000357656
    NIFKQ9BYG32, 3, ENSP000002858144MINT-50550 I2D: score=2 STRING: ENSP00000285814
    SMN1Q166372, 3MINT-8271289 I2D: score=2 
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006259DNA metabolic process IEA--
    GO:0007126meiotic nuclear division IEA--
    GO:0008283cell proliferation TAS17577209
    GO:0014070response to organic cyclic compound IEA--
    GO:0030212hyaluronan metabolic process IEA--

    MKI67 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for MKI67 (KI67)

    Selected Novoseek inferred chemical compound relationships for MKI67 gene (see all 81)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    paraffin 77.8 101 8163266 (3), 7496600 (2), 9392055 (2), 1484317 (2) (see all 92)
    progesterone 68.2 129 16972993 (4), 7865851 (3), 15377824 (3), 15979129 (3) (see all 99)
    estrogen 62.6 124 16972993 (4), 15979129 (3), 8137282 (2), 7865851 (2) (see all 98)
    bromodeoxyuridine 48.4 60 7855002 (7), 10730321 (3), 9589362 (3), 1670579 (2) (see all 29)
    hematoxylin 47.7 11 10410171 (1), 18083370 (1), 14707453 (1), 16425381 (1) (see all 11)
    vegf 47.3 92 15918184 (5), 19434817 (4), 15133868 (4), 15623373 (4) (see all 51)
    norcantharidin 47.1 8 15567755 (4), 16784656 (2), 17287171 (1)
    2-aminoacridone 34.6 2 7997128 (1), 7868749 (1)
    pyronin y 32.5 2 14976368 (1), 15277701 (1)
    tamoxifen 29.8 35 16972993 (4), 9499446 (4), 10542936 (4), 15289830 (3) (see all 11)

    1 PharmGKB related drug/compound annotation for MKI67 gene    About this table
    Drug/compound PharmGKB Annotation
    fulvestrant



    MKI67 for compounds           About GeneDecksing



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for MKI67 gene (2 alternative transcripts): 
    NM_001145966.1  NM_002417.4  

    Unigene Cluster for MKI67:

    Antigen identified by monoclonal antibody Ki-67
    Hs.80976  [show with all ESTs]
    Unigene Representative Sequence: X65550
    5 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000368653(uc001lkf.3 uc009yav.1 uc009yaw.1) ENST00000368654(uc001lke.3)
    ENST00000464771 ENST00000484853 ENST00000478293
    Congresses - knowledge worth sharing:
    European Congress of Clinical Microbiology and Infectious Diseases (ECCMID) 10 - 13 May 2014

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    GenScript: all cDNA clones in your preferred vector (see all 2): MKI67 (NM_002417)
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      QuantiFast Probe-based Assays in human, mouse, rat MKI67

    Additional mRNA sequence: 

    AJ567756.1 AJ567757.1 AK299254.1 X65550.1 X65551.1 

    15 DOTS entries:

    DT.100641296  DT.91752801  DT.218496  DT.100641976  DT.95335759  DT.91888764  DT.95148338  DT.95231686 
    DT.99972196  DT.100641975  DT.101975754  DT.92327801  DT.95289497  DT.95335757  DT.97848370 

    Selected AceView cDNA sequences (see all 374):

    AJ567757 AA301361 BM977483 BX493042 AW503684 AA262266 CF136127 BM796240 
    BQ944222 CF143534 BU431641 BG285094 AL556595 AA426264 AA236631 BX473776 
    BF916481 AA478568 BF792808 BU171176 BM455229 AW135734 W87907 BF968450 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for MKI67 (see all 8)    About this scheme

    ExUns: 1 ^ 2a · 2b ^ 3 ^ 4 ^ 5 ^ 6 ^ 7a · 7b ^ 8a · 8b ^ 9 ^ 10a · 10b ^ 11 ^ 12 ^ 13a · 13b ^ 14 ^ 15a · 15b ^ 16a · 16b · 16c ^ 17
    SP1:                    -     -                 -     -     -     -                                         -                                             
    SP2:                                                                                                                                                      
    SP3:                                                                                                                                                      
    SP4:                                                                                                                                                      
    SP5:                                                                                                                                                      


    ECgene alternative splicing isoforms for MKI67

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    MKI67 expression in normal human tissues (normalized intensities)      MKI67 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: AGGGCCGACT
    MKI67 Expression
    About this image


    MKI67 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 20) fully expand
     
     Brain (Nervous System)    fully expand to see all 6 entries
             Choroid Plexus Progenitor Cells Choroid Plexus
             Thalamus
     
     Neural Tube (Nervous System)    fully expand to see all 5 entries
             Metencephalon
     
     Eye (Sensory Organs)    fully expand to see all 3 entries
             GABAergic Amacrine Cells Inner Nuclear Layer
             Limbal epithelial stem cells (family)
     
     Thymus (Hematopoietic System)    fully expand to see all 2 entries
             Double Negative 2 Thymocytes Thymus
             Thymus
     
     Blood (Cardiovascular System)    fully expand to see all 2 entries
             Double Negative 2 Thymocytes Thymus
             Umbilical cord blood-derived mesenchymal stem cells
    MKI67 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    MKI67 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.80976
        Pathway & Disease-focused RT2 Profiler PCR Arrays including MKI67 (see all 7): 
              Lung Cancer in human mouse rat
              Cell Cycle in human mouse rat
              Breast Cancer in human mouse rat
              Cancer PathwayFinder in human mouse rat
              Lymphoma in human mouse rat

    Primer
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MKI67

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for MKI67 gene from Selected species (see all 11)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Mki671 , 5 antigen identified by monoclonal antibody Ki 671, 5 63.29(n)1
    46.5(a)1
      7 (81.32 cM)5
    173451  NM_001081117.21  NP_001074586.21 
     1356897885 
    chicken
    (Gallus gallus)
    Aves MKI676
    marker of proliferation Ki-67
    16(a)
    1 ↔ 1
    6(32890714-32910556)
    lizard
    (Anolis carolinensis)
    Reptilia MKI676
    marker of proliferation Ki-67
    24(a)
    1 ↔ 1
    3(54033699-54074342)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia Str.63642 Transcribed sequence with weak similarity to protein more 81.02(n)    141999050 
    zebrafish
    (Danio rerio)
    Actinopterygii mki676
    marker of proliferation Ki-67
    18(a)
    1 ↔ 1
    12(11445703-11460368) ENSDARG00000091150


    ENSEMBL Gene Tree for MKI67 (if available)
    TreeFam Gene Tree for MKI67 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for MKI67 gene

    MKI67 for paralogs           About GeneDecksing


    3 Pseudogenes.org Pseudogenes for MKI67
    PGOHUM00000238651 PGOHUM00000240074 PGOHUM00000241265


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for MKI67 (see all 1147)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 10 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1877545391,2
    --129894442(+) TCCCTC/TCCTCC 2 -- int10--------
    rs665977391,2
    C--129894522(+) GGACT-/AACT  
            
    GACCT
    2 -- int11Minor allele frequency- AACT:0.00NA 2
    rs27986671,2
    H--129894773(+) ATGACT/CTATTG 2 -- int14Minor allele frequency- C:0.00NS EA 420
    rs1476439641,2
    --129894776(+) ACTTAC/TTGGCC 2 -- int10--------
    rs1459731841,2
    C--129894816(+) CTTGT-/AGAAAT 2 -- int10--------
    rs27828771,2
    C,F,H--129894860(-) GACAGG/ACCAGT 2 -- int115Minor allele frequency- A:0.05NS EA NA 1666
    rs1925901541,2
    --129894954(+) TATTGA/GACATC 2 -- ut310--------
    rs84361,2
    C,F,O,A,H--129894983(-) TTACTC/GTATCC 2 -- ut31 ese320Minor allele frequency- G:0.33MN NA NS EA WA 1718
    rs1843616361,2
    C--129894988(+) GAGTAA/CCCAGG 2 -- ut310--------
    rs73481,2
    C,F--129894998(-) GACTGC/TATTTC 2 -- ut3113Minor allele frequency- T:0.29MN NA EA WA 954

    HapMap Linkage Disequilibrium report for MKI67 (129894923 - 129924649 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 7 variations for MKI67:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2676916CNV Deletion23128226
    esv2660735CNV Deletion23128226
    esv2743339CNV Deletion23290073
    nsv467481CNV Loss19166990
    dgv52n21CNV Loss19592680
    esv34105CNV Loss18971310
    nsv523484CNV Loss19592680

    Human Gene Mutation Database (HGMD): MKI67
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing MKI67
    DNA2.0 Custom Variant and Variant Library Synthesis for MKI67

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 176741    OMIM disorders: --

    Selected diseases for MKI67 (see all 222):    About MalaCards
    ovarian stromal hyperthecosis    brain ependymoma    intraocular melanoma    necrotizing sialometaplasia
    unilateral retinoblastoma    clear cell meningioma    sclerosing adenosis of breast    bladder adenocarcinoma
    sebaceous adenoma    ameloblastic carcinoma    cellular leiomyoma    spitz nevus
    pulmonary vein stenosis    gastrointestinal neuroendocrine tumor    soft tissue sarcoma    ovarian carcinosarcoma
    adenosarcoma    esophagus adenocarcinoma    parametritis    adrenal carcinoma

    3 diseases from the University of Copenhagen DISEASES database for MKI67:
    Carcinoma     Adenoma     Breast cancer

    MKI67 for disorders           About GeneDecksing


    Congresses - knowledge worth sharing:
    Alzheimer's & Parkinson's Diseases Congress (ADPD) 18 - 22 March 2015

    Selected Novoseek inferred disease relationships for MKI67 gene (see all 98)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    carcinoma 77.5 197 10452505 (5), 19087624 (4), 19447418 (3), 10697277 (3) (see all 99)
    tumors 76.5 688 8104388 (4), 14719452 (4), 19784424 (4), 15581977 (4) (see all 99)
    dysplasia 71.2 136 10931232 (5), 16948516 (4), 19087624 (4), 11428452 (4) (see all 60)
    metastasis 69.2 116 9537436 (3), 10456281 (3), 10854531 (3), 12479099 (3) (see all 76)
    adenoma 68.5 106 12239922 (4), 11396632 (4), 10452505 (4), 12645814 (3) (see all 61)
    carcinoma squamous cell 67.5 62 17317935 (4), 8879297 (3), 15588557 (3), 15899218 (3) (see all 46)
    adenocarcinoma 65.1 83 10382939 (6), 12647790 (4), 15638357 (3), 8104388 (2) (see all 54)
    residual radicular cyst 63.7 1 15610406 (1)
    breast carcinoma 61.5 33 10692218 (3), 8163266 (3), 8750578 (2), 8100059 (2) (see all 23)
    pituitary adenoma nonfunctioning 60.6 3 14567602 (2), 9030353 (1)

    Genetic Association Database (GAD): MKI67
    Human Genome Epidemiology (HuGE) Navigator: MKI67 (21 documents)

    Export disorders for MKI67 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for MKI67 gene, integrated from 10 sources (see all 1762):
    (articles sorted by number of sources associating them with MKI67)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Evaluation of candidate stromal epithelial cross-talk genes identifies association between risk of serous ovarian cancer and TERT, a cancer susceptibility &quot;hot-spot&quot;. (PubMed id 20628624)1, 4 Johnatty S.E.... . (PLoS Genet. 2010)
    2. Investigation of genetic susceptibility factors for human longevity - a targeted nonsynonymous SNP study. (PubMed id 20800603)1, 4 Flachsbart F....Nebel A. (Mutat. Res. 2010)
    3. Gene variants associated with ischemic stroke: the cardiovascular health study. (PubMed id 19023099)1, 4 Luke M.M....Psaty B.M. ( a journal of cerebral circulation 2009)
    4. Novel susceptibility loci for second primary tumors/recurrence in head and neck cancer patients: large-scale evaluation of genetic variants. (PubMed id 19584075)1, 4 Wu X....Hong W.K. (Cancer Prev Res (Phila) 2009)
    5. Fulfilling the promise of personalized medicine? Systematic review and field synopsis of pharmacogenetic studies. (PubMed id 19956635)1, 4 Holmes M.V....Casas J.P. (PLoS ONE 2009)
    6. Association of gene variants with incident myocardial infarction in the Cardiovascular Health Study. (PubMed id 17975119)1, 4 Shiffman D....Psaty B.M. (Arterioscler. Thromb. Vasc. Biol. 2008)
    7. Genome-wide association with select biomarker traits in the Framingham Heart Study. (PubMed id 17903293)1, 4 Benjamin E.J....Vasan R.S. (BMC Med. Genet. 2007)
    8. A probability-based approach for high-throughput protein phosphorylation analysis and site localization. (PubMed id 16964243)1, 2 Beausoleil S.A.... Gygi S.P. (Nat. Biotechnol. 2006)
    9. Ki-67 protein is associated with ribosomal RNA transcription in quiescent and proliferating cells. (PubMed id 16206250)1, 3 Bullwinkel J....Scholzen T. (J. Cell. Physiol. 2006)
    10. A scan of chromosome 10 identifies a novel locus showing strong association with late-onset Alzheimer disease. (PubMed id 16385451)1, 4 Grupe A....Goate A. (Am. J. Hum. Genet. 2006)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 4288 HGNC: 7107 AceView: MKI67 Ensembl:ENSG00000148773 euGenes: HUgn4288
    ECgene: MKI67 H-InvDB: MKI67

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for MKI67 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for MKI67 Genetics and Cytogenetics in Oncology and Haematology
    Wikipedia http://en.wikipedia.org/wiki/Ki-67_%28Biology%29

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for MKI67 gene:
    Search GeneIP for patents involving MKI67

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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