Aliases for MKI67 Gene
Aliases for MKI67 Gene
External Ids for MKI67 Gene
- HGNC: 7107
- Entrez Gene: 4288
- Ensembl: ENSG00000148773
- OMIM: 176741
- UniProtKB: P46013
Previous GeneCards Identifiers for MKI67 Gene
- GC10M128707
- GC10M128936
- GC10M129824
- GC10M129369
- GC10M129784
- GC10M123469
- GC10M129894
Summaries for MKI67 Gene
-
This gene encodes a nuclear protein that is associated with and may be necessary for cellular proliferation. Alternatively spliced transcript variants have been described. A related pseudogene exists on chromosome X. [provided by RefSeq, Mar 2009]
GeneCards Summary for MKI67 Gene
MKI67 (Marker Of Proliferation Ki-67) is a Protein Coding gene. Diseases associated with MKI67 include Pancreatic Neuroendocrine Tumor and Uterus Leiomyosarcoma. Among its related pathways are Neuroscience and DNA Damage. GO annotations related to this gene include poly(A) RNA binding and protein C-terminus binding.
UniProtKB/Swiss-Prot for MKI67 Gene
-
Required to maintain individual mitotic chromosomes dispersed in the cytoplasm following nuclear envelope disassembly (PubMed:27362226). Associates with the surface of the mitotic chromosome, the perichromosomal layer, and covers a substantial fraction of the chromosome surface (PubMed:27362226). Prevents chromosomes from collapsing into a single chromatin mass by forming a steric and electrostatic charge barrier: the protein has a high net electrical charge and acts as a surfactant, dispersing chromosomes and enabling independent chromosome motility (PubMed:27362226). Binds DNA, with a preference for supercoiled DNA and AT-rich DNA (PubMed:10878551). Does not contribute to the internal structure of mitotic chromosomes (By similarity). May play a role in chromatin organization (PubMed:24867636). It is however unclear whether it plays a direct role in chromatin organization or whether it is an indirect consequence of its function in maintaining mitotic chromosomes dispersed (Probable).
No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MKI67 Gene
Genomics for MKI67 Gene
Regulatory Elements for MKI67 Gene
Enhancers for MKI67 Gene
| GeneHancer Identifier | Enhancer Score | Enhancer Sources | Gene-Enhancer Score | TSS distance (kb) | Number of Genes Away | Size (kb) | Transcription Factor Binding Sites within enhancer | Gene Targets for Enhancer |
|---|---|---|---|---|---|---|---|---|
| GH10G128149 | 1.2 | Ensembl ENCODE | 12.8 | -23.7 | -23743 | 1.5 | SIN3A ZNF2 GLIS2 ZNF143 ZNF207 KLF7 ZNF263 REST SMARCA4 GLIS1 | MKI67 LINC01163 |
| GH10G128095 | 0.9 | FANTOM5 ENCODE | 12.7 | +30.4 | 30362 | 1.9 | MAX GLIS2 JUND POLR2A EGR1 GLIS1 ZNF341 PRDM10 BCL6 PRDM1 | MKI67 GC10M128107 GC10M128055 |
| GH10G128147 | 0.7 | ENCODE | 12.8 | -20.9 | -20907 | 0.2 | MTA2 BHLHE40 GATAD2B DPF2 TBX21 RELA ARID3A CBX5 IKZF1 ZNF143 | MKI67 LINC01163 |
| GH10G128148 | 0.6 | Ensembl | 12.8 | -21.5 | -21487 | 0.7 | PKNOX1 MTA2 GATAD2B DPF2 TBX21 JUND CBX5 NBN RELB IKZF2 | MKI67 LINC01163 |
| GH10G128085 | 0.5 | ENCODE | 12.5 | +39.9 | 39873 | 1.2 | SP5 POLR2A SMARCA4 CREB1 ATF2 | MKI67 GC10M128107 GC10M128055 |
- Elite enhancer and/or Elite enhancer-gene association
Download GeneHancer data dump
Enhancers around MKI67 on UCSC Golden Path with GeneCards custom track
- Transcription factor binding sites by QIAGEN in the MKI67 gene promoter:
Regulatory Element Products
Genomic Location for MKI67 Gene
- Chromosome:
- 10
- Start:
- 128,096,659 bp from pter
- End:
- 128,126,385 bp from pter
- Size:
- 29,727 bases
- Orientation:
- Minus strand
Genomic View for MKI67 Gene
Genes around MKI67 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 10q26.2 by Ensembl
- 10q26.2 by Entrez Gene
- 10q26.2 by HGNC
MKI67 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for MKI67 Gene
Proteins for MKI67 Gene
-
Protein details for MKI67 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- P46013-KI67_HUMAN
- Recommended name:
- Proliferation marker protein Ki-67
- Protein Accession:
- P46013
- Q5VWH2
Protein attributes for MKI67 Gene
- Size:
- 3256 amino acids
- Molecular mass:
- 358694 Da
- Quaternary structure:
-
- Interacts with KIF15 (PubMed:10878014). Interacts (via the FHA domain) with NIFK (PubMed:11342549, PubMed:14659764, PubMed:16244663). Interacts with PPP1CC (PubMed:24867636). Part of a complex composed at least of ASCL2, EMSY, HCFC1, HSPA8, CCAR2, MATR3, MKI67, RBBP5, TUBB2A, WDR5 and ZNF335; this complex may have a histone H3-specific methyltransferase activity (PubMed:19131338, PubMed:23178126).
Protein Expression for MKI67 Gene
Post-translational modifications for MKI67 Gene
- Phosphorylated. Hyperphosphorylated in mitosis (PubMed:10502411, PubMed:10653604). Hyperphosphorylated form does not bind DNA.
- Ubiquitination at Lys659, posLast=666666, Lys745, posLast=10431043, Lys1549, posLast=15921592, posLast=21382138, and Lys2289
- Modification sites at PhosphoSitePlus
Other Protein References for MKI67 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- EMD Millipore top MKI67 Antibody
- EMD Millipore Complete listing of Mono and Polychlonal Antibodies for MKI67
- R&D Systems Antibodies for MKI67 (Ki-67/MKI67)
- Cell Signaling Technology (CST) Antibodies for MKI67 (KI-67)
-
Custom Antibody ServicesOriGene Antibodies for MKI67
- UM870033
- CF803157
- CF802736
- CF802549
- CF802548
- CF802547
- CF802546
- CF802545
- CF802544
- CF802435
- CF802432
- CF802431
- CF802429
- CF802426
- CF802095
- CF801829
- CF801828
- CF801745
- CF801577
- CF801343
- CF801156
- CF801155
- CF801154
- CF800800
- CF800799
- CF800779
- CF800664
- CF800663
- CF800649
- CF800648
- CF500265
- TA353914
- TA353913
- TA352729
- TA336650
- TA336569
- TA336568
- TA336567
- TA336566
- DRM004
- DP026-05
- DP026
- AP31023PU-N
- AP22690PU-N
- AP15625PU-S
- AP15625PU-N
- AP15625PU-M
- AP06441PU-N
- AM33204PU-S
- AM33204PU-N
- AM33074PU-S
- AM33074PU-N
- AM11168PU-T
- AM11168PU-S
- AM11168PU-N
- AM06511SU-N
- AM06395SU-N
- AM06345SU-N
- AM01167RP-N
- AM01167PU-N
- Novus Biologicals Antibodies for MKI67
-
Abcam antibodies for MKI67
-
Cloud-Clone Corp. Antibodies for MKI67
- Invitrogen Antibodies for MKI67
- antibodies-online Antibodies for MKI67: See all 400
- GeneTex MKI67 antibody for MKI67
-
Santa Cruz Biotechnology (SCBT) Antibodies for MKI67
Protein Products
-
OriGene Purified Proteins for MKI67
- Search Origene for MassSpec and Protein Over-expression Lysates for MKI67
- Origene Custom Protein Services for MKI67
- Novus Biologicals proteins for MKI67
- Sino Biological Recombinant Proteins for MKI67
- Browse Sino Biological Cell Lysates
-
Cloud-Clone Corp. Proteins for MKI67
- antibodies-online Proteins for MKI67: See all 13
- Search antibodies-online for peptides
- Search GeneTex for Proteins for MKI67
-
Abcam proteins for MKI67
Assay Products
- R&D Systems ELISAs and other biochemical assays for MKI67 (Ki-67/MKI67)
- Cell Signaling Technology (CST) Sandwich ELISA Kits for MKI67 (KI-67)
- antibodies-online Kits for MKI67: See all 5
No data available for DME Specific Peptides for MKI67 Gene
Domains & Families for MKI67 Gene
Gene Families for MKI67 Gene
Protein Domains for MKI67 Gene
- InterPro:
- Blocks:
- ProtoNet:
Suggested Antigen Peptide Sequences for MKI67 Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
No data available for UniProtKB/Swiss-Prot for MKI67 Gene
Function for MKI67 Gene
Molecular function for MKI67 Gene
- GENATLAS Biochemistry:
- antigen identified by monoclonal antibody Ki-67 (non histone protein 395/345kDa)
- UniProtKB/Swiss-Prot Function:
- Required to maintain individual mitotic chromosomes dispersed in the cytoplasm following nuclear envelope disassembly (PubMed:27362226). Associates with the surface of the mitotic chromosome, the perichromosomal layer, and covers a substantial fraction of the chromosome surface (PubMed:27362226). Prevents chromosomes from collapsing into a single chromatin mass by forming a steric and electrostatic charge barrier: the protein has a high net electrical charge and acts as a surfactant, dispersing chromosomes and enabling independent chromosome motility (PubMed:27362226). Binds DNA, with a preference for supercoiled DNA and AT-rich DNA (PubMed:10878551). Does not contribute to the internal structure of mitotic chromosomes (By similarity). May play a role in chromatin organization (PubMed:24867636). It is however unclear whether it plays a direct role in chromatin organization or whether it is an indirect consequence of its function in maintaining mitotic chromosomes dispersed (Probable).
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0003677 | DNA binding | IEA | -- |
| GO:0003723 | RNA binding | IDA | 22658674 |
| GO:0005515 | protein binding | IPI | 10878014 |
| GO:0005524 | ATP binding | IEA | -- |
| GO:0008022 | protein C-terminus binding | IPI | 17577209 |
Phenotypes for MKI67 Gene
- MGI mutant phenotypes for MKI67:
- inferred from 1 alleles
- GenomeRNAi human phenotypes for MKI67:
-
- Increased viability
- Increased vaccinia virus (VACV) infection
- Synthetic lethal with Ras
- Decreased shRNA abundance
- Synthetic lethal with vaccinia virus (VACV) infection
- Increased cell death in breast cancer cell lines (MCF10A, MDA-MB-435)
- Increased Nanog expression
- Upregulation of Wnt/beta-catenin pathway after WNT3A stimulation
- Decreased caspase 3/7 activity
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
- Cyagen custom Knockout/knockin (KOKI) mouse models for MKI67
-
-
ViGene Biosciences lentiviral particle packaged cDNA for MKI67 gene
-
ViGene Biosciences ready-to-package AAV shRNAs for MKI67 gene
- Search ViGene Biosciences for MKI67
CRISPR Products
-
OriGene CRISPR knockouts for MKI67
-
Santa Cruz Biotechnology (SCBT) CRISPR for MKI67
- GenScript: Design CRISPR guide RNA sequences for MKI67
miRNA for MKI67 Gene
- miRTarBase miRNAs that target MKI67
-
- hsa-mir-519d-3p (MIRT006792)
- hsa-mir-1-3p (MIRT023674)
- hsa-mir-215-5p (MIRT024267)
- hsa-mir-34a-5p (MIRT025361)
- hsa-mir-192-5p (MIRT026336)
- hsa-mir-16-5p (MIRT031529)
- hsa-mir-1909-5p (MIRT035804)
- hsa-mir-1296-5p (MIRT036119)
- hsa-mir-877-3p (MIRT037098)
- hsa-mir-615-3p (MIRT040461)
- hsa-mir-505-3p (MIRT041044)
- hsa-mir-484 (MIRT041876)
- hsa-mir-331-3p (MIRT043477)
- hsa-mir-328-3p (MIRT043812)
- hsa-mir-221-3p (MIRT046919)
- hsa-mir-29b-3p (MIRT048383)
- hsa-mir-92a-3p (MIRT049015)
- hsa-mir-17-5p (MIRT051037)
- hsa-let-7e-5p (MIRT051657)
- hsa-mir-218-5p (MIRT440239)
- hsa-mir-6894-3p (MIRT512947)
- hsa-mir-1298-5p (MIRT512948)
- hsa-mir-550a-5p (MIRT512949)
- hsa-mir-550a-3-5p (MIRT512950)
- hsa-mir-1271-3p (MIRT512951)
- hsa-mir-4763-5p (MIRT512952)
- hsa-mir-664a-3p (MIRT512953)
- hsa-mir-519e-3p (MIRT512954)
- hsa-mir-515-3p (MIRT512955)
- hsa-mir-33b-3p (MIRT512956)
- hsa-mir-4523 (MIRT512957)
- hsa-mir-4474-3p (MIRT573883)
- hsa-mir-5587-5p (MIRT573884)
- hsa-mir-6842-3p (MIRT573885)
- hsa-mir-653-3p (MIRT573886)
- hsa-mir-5787 (MIRT573887)
- hsa-mir-4505 (MIRT573888)
- hsa-mir-3652 (MIRT573889)
- hsa-mir-4430 (MIRT573890)
- hsa-mir-6131 (MIRT573891)
- hsa-mir-6506-5p (MIRT573892)
- hsa-mir-619-5p (MIRT573893)
- hsa-mir-1976 (MIRT573894)
- hsa-mir-3653-5p (MIRT573895)
- hsa-mir-1914-5p (MIRT573896)
- hsa-mir-3074-5p (MIRT573897)
- hsa-mir-4326 (MIRT573898)
- hsa-mir-1185-5p (MIRT573899)
- hsa-mir-3679-5p (MIRT573900)
- hsa-mir-6747-3p (MIRT573901)
- hsa-mir-6727-3p (MIRT573902)
- hsa-mir-4722-3p (MIRT573903)
- hsa-mir-6083 (MIRT693190)
- hsa-mir-3978 (MIRT693191)
- hsa-mir-4699-5p (MIRT693192)
- hsa-mir-1283 (MIRT693193)
- hsa-mir-520h (MIRT693194)
- hsa-mir-520g-3p (MIRT693195)
- hsa-mir-1252-3p (MIRT693196)
- hsa-mir-3646 (MIRT693197)
- hsa-mir-4796-3p (MIRT693198)
- hsa-mir-559 (MIRT693199)
- hsa-mir-548y (MIRT693200)
- hsa-mir-548w (MIRT693201)
- hsa-mir-548o-5p (MIRT693202)
- hsa-mir-548j-5p (MIRT693203)
- hsa-mir-548i (MIRT693204)
- hsa-mir-548h-5p (MIRT693205)
- hsa-mir-548d-5p (MIRT693206)
- hsa-mir-548c-5p (MIRT693207)
- hsa-mir-548bb-5p (MIRT693208)
- hsa-mir-548b-5p (MIRT693209)
- hsa-mir-548ay-5p (MIRT693210)
- hsa-mir-548au-5p (MIRT693211)
- hsa-mir-548as-5p (MIRT693212)
- hsa-mir-548ar-5p (MIRT693213)
- hsa-mir-548aq-5p (MIRT693214)
- hsa-mir-548ap-5p (MIRT693215)
- hsa-mir-548am-5p (MIRT693216)
- hsa-mir-548ak (MIRT693217)
- hsa-mir-548ae-5p (MIRT693218)
- hsa-mir-548ad-5p (MIRT693219)
- hsa-mir-548ab (MIRT693220)
- hsa-mir-548a-5p (MIRT693221)
miRNA Products
- Search ViGene Biosciences for MKI67
Inhibitory RNA Products
- Origene RNAi, siRNA, and shRNA products in human, mouse, rat for MKI67
- Browse OriGene Inhibitory RNA Products For MKI67
-
ViGene Biosciences ready-to-package AAV shRNAs for MKI67 gene
Clone Products
- Sino Biological Human cDNA Clone for MKI67
- Addgene plasmids for MKI67
- VectorBuilder custom plasmid, inducible vectors for MKI67
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for MKI67
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
Cell Line Products
-
Horizon Cell Lines for MKI67
-
ViGene Biosciences adenoviral particle packaged cDNA for MKI67 gene
-
ViGene Biosciences lentiviral particle packaged cDNA for MKI67 gene
-
ViGene Biosciences ready-to-package AAV shRNAs for MKI67 gene
Flow Cytometry Products
- eBioscience FlowRNA Probe Sets (VA1-11033 VA6-13415) for MKI67
No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for MKI67 Gene
Localization for MKI67 Gene
Subcellular locations from UniProtKB/Swiss-Prot for MKI67 Gene
- Chromosome. Nucleus. Nucleus, nucleolus. Note=Associates with the surface of the mitotic chromosome, the perichromosomal layer, and covers a substantial fraction of the mitotic chromosome surface (PubMed:27362226). Associates with satellite DNA in G1 phase (PubMed:9510506). Binds tightly to chromatin in interphase, chromatin-binding decreases in mitosis when it associates with the surface of the condensed chromosomes (PubMed:15896774, PubMed:22002106). Predominantly localized in the G1 phase in the perinucleolar region, in the later phases it is also detected throughout the nuclear interior, being predominantly localized in the nuclear matrix (PubMed:22002106). {ECO:0000269 PubMed:15896774, ECO:0000269 PubMed:22002106, ECO:0000269 PubMed:27362226}.
| Compartment | Confidence |
|---|---|
| nucleus | 5 |
| mitochondrion | 2 |
| plasma membrane | 1 |
| extracellular | 1 |
| cytoskeleton | 1 |
| cytosol | 1 |
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000775 | chromosome, centromeric region | IEA | -- |
| GO:0000793 | colocalizes_with condensed chromosome | IDA,IEA | 27362226 |
| GO:0005634 | nucleus | IDA,IEA | 22378020 |
| GO:0005694 | chromosome | IEA | -- |
| GO:0005730 | nucleolus | IDA,IEA | 17577209 |
Pathways & Interactions for MKI67 Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | DNA Damage | ||
| 2 | Neuroscience | ||
| 3 | Primary Focal Segmental Glomerulosclerosis FSGS | ||
Pathways by source for MKI67 Gene
2 Cell Signaling Technology pathways for MKI67 Gene
1 BioSystems pathway for MKI67 Gene
Interacting Proteins for MKI67 Gene
Selected Interacting proteins:
P46013-KI67_HUMAN
ENSP00000357643
for MKI67 Gene via
IID
STRING
UniProtKB
MINT
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0006259 | DNA metabolic process | IEA | -- |
| GO:0007049 | cell cycle | IEA | -- |
| GO:0007088 | regulation of mitotic nuclear division | IDA | 27362226 |
| GO:0007126 | meiotic nuclear division | IEA | -- |
| GO:0008283 | cell proliferation | TAS | 17577209 |
No data available for SIGNOR curated interactions for MKI67 Gene
Drugs & Compounds for MKI67 Gene
| Name | Status | Disease Links | Group | Role | Mechanism of Action | Clinical Trials |
|---|---|---|---|---|---|---|
| Fulvestrant | Approved, Investigational | Pharma | Antagonist | Estrogen receptor antagonist,high affinity, Hormone therapy | 202 |
| Name | Synonyms | Role | CAS Number | PubChem IDs | PubMed IDs |
|---|
Transcripts for MKI67 Gene
mRNA/cDNA for MKI67 Gene
- (4) REFSEQ mRNAs :
- (374) Selected AceView cDNA sequences:
- (5) Ensembl transcripts including schematic representations, and UCSC links where relevant :
CRISPR Products
-
OriGene CRISPR knockouts for MKI67
-
Santa Cruz Biotechnology (SCBT) CRISPR for MKI67
- GenScript: Design CRISPR guide RNA sequences for MKI67
miRNA Products
- Search ViGene Biosciences for MKI67
Inhibitory RNA Products
- Origene RNAi, siRNA, and shRNA products in human, mouse, rat for MKI67
- Browse OriGene Inhibitory RNA Products For MKI67
-
ViGene Biosciences ready-to-package AAV shRNAs for MKI67 gene
Clone Products
- Sino Biological Human cDNA Clone for MKI67
- Addgene plasmids for MKI67
- VectorBuilder custom plasmid, inducible vectors for MKI67
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for MKI67
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
Flow Cytometry Products
- eBioscience FlowRNA Probe Sets (VA1-11033 VA6-13415) for MKI67
| ExUns: | 1 | ^ | 2a | · | 2b | ^ | 3 | ^ | 4 | ^ | 5 | ^ | 6 | ^ | 7a | · | 7b | ^ | 8a | · | 8b | ^ | 9 | ^ | 10a | · | 10b | ^ | 11 | ^ | 12 | ^ | 13a | · | 13b | ^ | 14 | ^ | 15a | · | 15b | ^ | 16a | · | 16b | · | 16c | ^ | 17 |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | - | - | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||
| SP2: | |||||||||||||||||||||||||||||||||||||||||||||||||
| SP3: | |||||||||||||||||||||||||||||||||||||||||||||||||
| SP4: | |||||||||||||||||||||||||||||||||||||||||||||||||
| SP5: | |||||||||||||||||||||||||||||||||||||||||||||||||
| SP6: | |||||||||||||||||||||||||||||||||||||||||||||||||
| SP7: | - | ||||||||||||||||||||||||||||||||||||||||||||||||
| SP8: | - |
Expression for MKI67 Gene
mRNA differential expression in normal tissues according to GTEx for MKI67 Gene
This gene is overexpressed in Esophagus - Mucosa (x4.3).
This gene is overexpressed in Placenta (20.3), Kidney (13.4), Fetal testis (8.5), Liver (7.5), and Esophagus (6.3).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for MKI67 Gene
NURSA nuclear receptor signaling pathways regulating expression of MKI67 Gene:
MKI67SOURCE GeneReport for Unigene cluster for MKI67 Gene:
Hs.80976Evidence on tissue expression from TISSUES for MKI67 Gene
- Intestine(3.4)
- Liver(2.8)
- Blood(2.7)
- Lung(2.3)
- Lymph node(2.2)
- Bone marrow(2)
Primer Products
-
OriGene qPCR primer pairs for MKI67
No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for MKI67 Gene
Orthologs for MKI67 Gene
This gene was present in the common ancestor of chordates.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| chimpanzee (Pan troglodytes) |
Mammalia | MKI67 34 35 |
|
||
| dog (Canis familiaris) |
Mammalia | MKI67 34 35 |
|
||
| cow (Bos Taurus) |
Mammalia | MKI67 34 35 |
|
||
| rat (Rattus norvegicus) |
Mammalia | Mki67 34 |
|
||
| mouse (Mus musculus) |
Mammalia | Mki67 34 16 35 |
|
||
| oppossum (Monodelphis domestica) |
Mammalia | MKI67 35 |
|
OneToOne | |
| chicken (Gallus gallus) |
Aves | MKI67 35 |
|
OneToOne | |
| lizard (Anolis carolinensis) |
Reptilia | MKI67 35 |
|
OneToOne | |
| tropical clawed frog (Silurana tropicalis) |
Amphibia | Str.6364 34 |
|
||
| zebrafish (Danio rerio) |
Actinopterygii | mki67 35 |
|
OneToOne | |
| sea squirt (Ciona savignyi) |
Ascidiacea | -- 35 |
|
OneToOne |
- Species where no ortholog for MKI67 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- fruit fly (Drosophila melanogaster)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- platypus (Ornithorhynchus anatinus)
- rainbow trout (Oncorhynchus mykiss)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- wheat (Triticum aestivum)
- worm (Caenorhabditis elegans)
Paralogs for MKI67 Gene
Pseudogenes.org Pseudogenes for MKI67 Gene
No data available for Paralogs for MKI67 Gene
Variants for MKI67 Gene
| SNP ID | Clin | Chr 10 pos | Sequence Context | AA Info | Type |
|---|---|---|---|---|---|
| rs796052184 | Likely benign | 128,104,734(-) | AGACG(C/T)AGAGG | reference, missense | |
| rs1000336206 | -- | 128,120,515(+) | AAACA(A/G)AAAGA | intron-variant | |
| rs1000512453 | -- | 128,114,183(+) | GCCAC(C/T)TGCAG | intron-variant | |
| rs1000562547 | -- | 128,117,614(+) | CAAAG(G/T)CAAAG | intron-variant | |
| rs1000565458 | -- | 128,113,305(+) | AACTT(A/G)TTTCT | intron-variant |
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| dgv52n21 | CNV | loss | 19592680 |
| dgv989n100 | CNV | gain | 25217958 |
| esv2660735 | CNV | deletion | 23128226 |
| esv2676916 | CNV | deletion | 23128226 |
| esv34105 | CNV | loss | 18971310 |
| esv3624896 | CNV | loss | 21293372 |
| nsv467481 | CNV | loss | 19166990 |
| nsv523484 | CNV | loss | 19592680 |
| nsv552312 | CNV | loss | 21841781 |
| nsv552313 | CNV | loss | 21841781 |
Residual Variation Intolerance Score:
99.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
25.13;
99.69% of all genes are more intolerant (likely to be disease-causing)
Relevant External Links for MKI67 Gene
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MKI67 Gene
Disorders for MKI67 Gene
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| pancreatic neuroendocrine tumor |
|
|
| uterus leiomyosarcoma |
|
|
| ameloblastic carcinoma |
|
|
| brain ependymoma |
|
|
| cervical intraepithelial neoplasia |
|
Search MKI67 in MalaCards
View complete list of genes associated with diseases
Relevant External Links for MKI67
No data available for UniProtKB/Swiss-Prot and Genatlas for MKI67 Gene
Publications for MKI67 Gene
- Ki-67 acts as a biological surfactant to disperse mitotic chromosomes. (PMID: 27362226) Cuylen S. … Gerlich D.W. (Nature 2016) 3 4 64
- Ki-67 is a PP1-interacting protein that organises the mitotic chromosome periphery. (PMID: 24867636) Booth D.G. … Vagnarelli P. (Elife 2014) 3 4 64
- Evaluation of candidate stromal epithelial cross-talk genes identifies association between risk of serous ovarian cancer and TERT, a cancer susceptibility "hot-spot". (PMID: 20628624) Johnatty S.E. … . (PLoS Genet. 2010) 3 46 64
- Investigation of genetic susceptibility factors for human longevity - a targeted nonsynonymous SNP study. (PMID: 20800603) Flachsbart F. … Nebel A. (Mutat. Res. 2010) 3 46 64
- Immunohistochemical overexpression of the p53 protein and Ki-67 (MIB-1) antigen in patients with GERD and chronic esophagitis. (PMID: 20414055) Binato M. … Edelweiss M.I. (Appl. Immunohistochem. Mol. Morphol. 2010) 3 22 64
Products for MKI67 Gene
- R&D Systems Antibodies for MKI67 (Ki-67/MKI67)
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- Custom Antibody ServicesOriGene Antibodies for MKI67
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- Santa Cruz Biotechnology (SCBT) Antibodies for MKI67
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- VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
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- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
Sources for MKI67 Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
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- (14) ProtoNet
- (15) Blocks
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- (23) PharmGKB
- (24) DrugBank
- (25) HMDB
- (26) UniGene
- (27) AceView
- (28) RNAdb
- (29) ASD
- (30) ECgene
- (31) GeneAnnot
- (32) CGAP SAGE
- (33) SOURCE
- (34) HomoloGene
- (35) PanEnsembl
- (36) euGenes
- (37) SGD
- (38) FlyBase
- (39) WormBase
- (40) Pseudogene
- (41) DGV
- (42) dbSNP
- (43) GenAtlas
- (44) GeneTests
- (45) HGMD
- (46) GAD
- (47) LSDB
- (48) BGMUT
- (49) HuGE
- (50) eBioscience
- (51) Atlas
- (52) Cell Signaling Technology
- (53) GenBank
- (54) H-invDB
- (55) HORDE
- (56) HUGE
- (57) IMGT
- (58) Leiden
- (59) MILLIPORE
- (60) miRBase
- (61) DME
- (62) NCBI
- (63) OriGene
- (64) PubMed
- (65) R&D Systems
- (66) TGDB
- (67) Tocris
- (68) Abcam
- (69) Novus
- (70) ProSpec
- (71) Sino Biological
- (72) GenScript
- (73) Qiagen
- (74) Cloud-Clone Corp.
- (75) Enzo Life Sciences
- (76) OCA
- (77) Proteopedia
- (78) MOPED
- (79) SPIRE
- (80) neXtProt
- (81) Reactome
- (82) GeneGo (Thomson Reuters)
- (83) fRNAdb
- (84) DISEASES
- (85) SIMAP
- (86) GenomeRNAi
- (87) LifeMap
- (88) miRTarBase
- (89) MalaCards
- (90) Invitrogen
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- (92) Vector BioLabs
- (93) ESI-BIO
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- (97) IUPHAR
- (98) BioGPS
- (99) Illumina
- (100) COMPARTMENTS
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- (103) ApexBio
- (104) Addgene
- (105) antibodies-online
- (106) CYP
- (107) NONCODE
- (108) SwitchGear Genomics
- (109) TreeFam
- (110) PathCards
- (111) GeneReviews
- (112) GeneTex
- (113) Taconic Biosciences
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- (153) dbSUPER
- (154) TISSUES
- (155) Gene ORGANizer