V3 here soon-try beta now


Gene Search (GeneCards Home)	\|	GeneCards Guide	\|	User Feedback	\|	Terms of Use	\|	Notice about third-party sites

MKI67 Gene

protein-coding GIFtS: 62

GC10M129784

antigen identified by monoclonal antibody Ki-67
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc , and/or ⁷Ensembl, ⁸miRBase)
About This Section

Aliases
KIA ^²
OTTHUMP00000020739 ^²

Descriptions
antigen identified by monoclonal antibody Ki-67 ^²
proliferation-related Ki-67 antigen ^²

External Ids
HGNC: 7107¹
Entrez Gene: 4288²
UniProtKB: P46013³
Ensembl: ENSG00000148773⁷

Search outside databases for aliases for MKI67 gene

Previous GC identifers: GC10M128707 GC10M128936 GC10M129824 GC10M129369

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

EntrezGene summary for MKI67:

This gene encodes a nuclear protein that is associated with and may be necessary for cellular

proliferation. Alternatively spliced transcript variants have been described. A related pseudogene

exists on chromosome X. [provided by RefSeq]

UniProtKB/Swiss-Prot: KI67_HUMAN, P46013

Function: Thought to be required for maintaining cell proliferation

Gene Wiki entry for MKI67 (Ki-67)

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
About This Section

Genomic View:

UCSC Golden Path with GeneCards custom track

Transcription factor binding sites upstream to the MKI67 gene

Entrez Gene cytogenetic band: 10q25-qter Ensembl cytogenetic band: 10q26.2 HGNC cytogenetic band: 10q26.2

MKI67 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 10 GeneLoc Exon Structure

GeneLoc location for GC10M129784: (about GC identifiers)

Start:	129,784,913 bp from pter
End:	129,814,645 bp from pter
Size:	29,733 bases
Orientation:	minus strand

RefSeq DNA sequence:

NC_000010.9 NT_008818.15

(According to ¹UniProtKB, and/or Ensembl, Phosphorylation sites according to ²Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
About This Section

UniProtKB/Swiss-Prot: KI67_HUMAN, P46013 (See protein sequence)

Recommended Name: Antigen KI-67

Size: 3256 amino acids; 358694 Da

Subunit: Interacts with KIF15. Binds through the FHA domain to MKI67IP

Subcellular location: Nucleus. Note=Predominantly localized in the G1 phase in the perinucleolar

region, in the later phases it is also detected throughout the nuclear interior, being

predominantly localized in the nuclear matrix. In mitosis, it is present on all chromosomes

Developmental stage: Expression of this antigen occurs preferentially during late G1, S, G2 and M

phases of the cell cycle, while in cells in G0 phase the antigen cannot be detected

PDB structure from and Proteopedia :

1R21 (3D)

2AFF (3D)

Secondary accessions: Q5VWH2

Alternative splicing: 2 isoforms: P46013-1 P46013-2

Post-translational modifications:

View phosphorylation sites using PhosphoSite²

REFSEQ proteins (2 alternative transcripts):

NP_001139438.1 NP_002408.3

ENSEMBL proteins:

ENSP00000357643 ENSP00000357642 ENSP00000357641 ENSP00000357640

Human Recombinant Proteins

	Browse Drug Discovery Central at Invitrogen for human recombinant proteins
	Browse Purified and Recombinant Proteins at Millipore
	Browse Human Recombinant Proteins at Sigma-Aldrich
	Browse R&D Systems for human recombinant proteins
	Browse recombinant and purified proteins available from Enzo Life Sciences
	Recombinant Proteins from Abcam (Ki67)
	Human Recombinant Proteins from Abnova (MKI67)

Browse Origene for full length recombinant human proteins expressed in human HEK293 cells

2 Gene Ontology (GO) cellular component terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005634	nucleus	IEA	--
GO:0005730	nucleolus	IDA	18029348

About this table

Antibodies for MKI67:

	Invitrogen Antibodies for MKI67
	Millipore Mono- and Polyclonal Antibodies for the study of MKI67
	Sigma-Aldrich Antibody Arrays and Antibodies for MKI67
	Browse R&D Systems for Antibodies
	Antibodies from Abcam (Ki67), each with their Abpromise^SM
	Monoclonal and Polyclonal Antibodies from Abnova (MKI67)
	Novus Biologicals Antibodies for MKI67

Assays for MKI67:

	Browse Invitrogen for biochemical assays
	Browse Kits and Assays available from Millipore
	Browse R&D Systems for biochemical assays
	Browse biochemical assays available from Enzo Life Sciences

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

Graphical View of Domain Structure for InterPro Entry P46013

ProtoNet protein and cluster: P46013

2 Blocks protein families:

IPB000253 Forkhead-associated (FHA)

IPB012568 K167R

UniProtKB/Swiss-Prot: KI67_HUMAN, P46013

Similarity: Contains 1 FHA domain

(According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (MKI67)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (MKI67)

OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 2): NM_002417

Applied Biosystems Silencer® siRNAs for MKI67

Sigma-Aldrich siRNA for MKI67

Sigma-Aldrich shRNA for MKI67

Explore Sigma-Aldrich super-pooled esiRNAs

Clones:		Browse Clone Ranger at Invitrogen for clones
		Browse Clones for the Expression of Recombinant Proteins Available from Millipore

OriGene GFP tagged cDNA clones in CMV expression vector (see all 2): NM_001145966
Myc/DDK tagged cDNA clones in CMV expression vector (see all 2): NM_001145966
untagged cDNA clones in CMV expression vector (see all 2): NM_001145966

Primers:

Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers

OriGene genome-wide validated SYBR primer pairs: NM_002417

UniProtKB/Swiss-Prot: KI67_HUMAN, P46013

Function: Thought to be required for maintaining cell proliferation

Genatlas biochemistry entry for MKI67:

antigen identified by monoclonal antibody Ki-67 (non histone protein 395/345kDa)

3 Gene Ontology (GO) molecular function terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0000166	nucleotide binding	IEA	--
GO:0005515	protein binding	IPI	11342549
GO:0005524	ATP binding	IEA	--

About this table

(Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to ¹UniProtKB, ²MINT, and/or ³STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section

Gene Network Central^TM Interacting Genes and Proteins Network for MKI67

5/118 Interacting proteins for MKI67 (ENSP00000357643³ P46013^{1, 2}) via UniProtKB, MINT, and/or STRING (see all 118 )

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
MKI67IP	Q9BYG3²	STRING (score=.95) MINT-50550 MINT-50549 MINT-50548
ABL1	P00519¹	EBI-876367, EBI-375543
FYN	P06241¹	EBI-876367, EBI-515315
SRC	P12931¹	EBI-876367, EBI-621482
KIF15	Q9NS87²	MINT-14343 MINT-14342

About this table

2 Gene Ontology (GO) biological process terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0007049	cell cycle	IEA	--
GO:0008283	cell proliferation	TAS	8227122

About this table

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

Browse drugs & compounds from Enzo Life Sciences

Browse Small Molecules at Sigma-Aldrich

Browse Tocris compounds for MKI67
10/37 Novoseek chemical compound relationships for MKI67 gene (see all 37 )

Compound	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
progesterone	67.11	113	16972993 (4), 7865851 (3), 15377824 (3), 15979129 (3) (see all 92)
norcantharidin	49.87	8	15567755 (4), 16784656 (2), 17287171 (1)
bromodeoxyuridine	49.85	60	7855002 (7), 10730321 (3), 9589362 (3), 1670579 (2) (see all 29)
hematoxylin	48.72	11	10410171 (1), 18083370 (1), 14707453 (1), 16425381 (1) (see all 11)
2-aminoacridone	35.95	2	7997128 (1), 7868749 (1)
pyronin y	34.28	2	14976368 (1), 15277701 (1)
steroid	27.95	28	9499446 (3), 8911118 (1), 11232637 (1), 14667969 (1) (see all 25)
p00001	27.65	1	10607921 (1)
dutp	20.79	6	14736730 (1), 10716912 (1), 14984954 (1), 11260306 (1) (see all 6)
thymidine	18.87	19	1340164 (1), 10418718 (1), 10699888 (1), 11745251 (1) (see all 16)

About this table

(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Invitrogen, Millipore, and/or Abnova,
siRNAs from Applied Biosystems, Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene,
Tagged/untagged cDNA clones from OriGene,
Expression Assays from Applied Biosystems)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (MKI67)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (MKI67)

OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 2): NM_002417

Sigma-Aldrich siRNA for MKI67

Sigma-Aldrich shRNA for MKI67

Explore Sigma-Aldrich super-pooled esiRNAs

Applied Biosystems Silencer® siRNAs:

NM_002417

REFSEQ mRNAs for MKI67 gene (2 alternative transcripts):

NM_001145966.1 NM_002417.4

Applied Biosystems TaqMan ® Gene Expression Assays:

NM_002417

               OriGene GFP tagged cDNA clones in CMV expression vector (see all 2): NM_001145966
                                 Myc/DDK tagged cDNA clones in CMV expression vector (see all 2): NM_001145966
                                 untagged cDNA clones in CMV expression vector (see all 2): NM_001145966

Additional cDNA sequence: AJ567755.1

15 DOTS entries:

DT.100641296 DT.91752801 DT.218496 DT.100641976 DT.95335759 DT.91888764 DT.95148338 DT.95231686

DT.99972196 DT.100641975 DT.92327801 DT.95289497 DT.95335757 DT.101975754 DT.97848370

24/374 AceView cDNA sequences (see all 374 ):

BU154307 AA262266 BX493042 BP365434 BF968450 BU171176 BU541992 BM796240

BF916481 BM682971 BM977483 W87907 BM455791 BU431641 BG285094 BX118911

BF792808 AI696794 BM833044 BX473776 BG389162 BQ005613 BG256413 BM806835

highest scoring ESTs for MKI67:

X65550 AA355973 X65551 AA004872 AA005072 AA009640 AA010117 AA010118 AA041194 AA041431

Unigene Clusters for MKI67:

Antigen identified by monoclonal antibody Ki-67

Hs.80976 [show with all ESTs], Hs.689823

Unigene Representative Sequences: X65550, AJ567755

GeneLoc Exon Structure

5/8 Alternative Splicing Database (ASD) splice patterns (SP) for MKI67 (see all 8 )

ExUns:	1	^	2a	·	2b	^	3	^	4	^	5	^	6	^	7a	·	7b	^	8a	·	8b	^	9	^	10a	·	10b	^	11	^	12	^	13a	·	13b	^	14	^	15a	·	15b	^	16a	·	16b	·	16c	^	17
SP1:							-		-						-		-		-		-														-
SP2:
SP3:
SP4:
SP5:

About this scheme

ECgene alternative splicing isoforms for MKI67

4 Ensembl transcripts including schematic representations:

ENST00000368654 ENST00000368653 ENST00000368652 ENST00000368651

(Experimental results according to ¹GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to ²GeneAnnot , ³GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Expression Assays from Applied Biosystems )
About This Section

MKI67 expression in normal and diseased human tissues

Applied Biosystems TaqMan ® Gene Expression Assays for MKI67

¹ / ² / ³

10 probe-sets matching MKI67 gene

Affymetrix probe-set	Array	# genes	Sensitivity	Specificity	Correlation	Length	Gb_Accession	Consensus	Uniqueness	Score	Rank
Affymetrix probe-set	Array	GeneAnnot data			GeneNote data		GeneTide data
419_at²^{, 3}	U95-A	1	1.00	1.00	0.97	1.20	X65550	1.00	1.00	1.00	1
418_at²^{, 3}	U95-A	1	1.00	1.00	0.96	0.82	X65550	1.00	1.00	1.00	1
212020_s_at²^{, 3}	U133-A	1	1.00	1.00	--	--	AU152107	0.40	1.00	0.76	1
212022_s_at²^{, 3}	U133-A	1	1.00	1.00	--	--	BF001806	0.60	1.00	0.82	1
212023_s_at²^{, 3}	U133-A	1	1.00	1.00	--	--	AU147044	0.40	1.00	0.76	1
212021_s_at²^{, 3}	U133-A	1	1.00	1.00	--	--	AU132185	0.60	1.00	0.82	1
212020_s_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
212022_s_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
212023_s_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
212021_s_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--

GeneDecks MKI67 for binary patterns associated with the probe-sets selected above

About GeneDecksing

About this table

Data from

(Publications) and GNF BioGPS
About these images
About these images

CGAP SAGE TAG: --

SOURCE GeneReport for Unigene clusters: Hs.80976 Hs.689823
Expression variation in blood from EXPOLDB for MKI67

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD and/or ⁵MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
About This Section

Orthologs for MKI67 gene from 5 species

Organism	Gene	Locus	Description	Human Similarity	NCBI accessions
chimpanzee (Pan troglodytes)	MKI67¹	--	antigen identified by monoclonal antibody Ki-67	98.9(n) 97.97(a)	450866 XM_508147.2 XP_508147.2
cow (Bos taurus)	MKI67¹	--	antigen identified by monoclonal antibody Ki-67	69.1(n) 63.46(a)	513220 XM_590872.3 XP_590872.3
rat (Rattus norvegicus)	Mki67¹	--	antigen identified by monoclonal antibody Ki-67	61.89(n) 44.07(a)	291234 XM_225460.4 XP_225460.4
mouse (Mus musculus)	Mki67^{1, 5}	7⁵	antigen identified by monoclonal antibody Ki 67^{1, 5}	61.87(n)¹ 44.93(a)¹	17345¹ XM_001479849.1¹ XP_001479899.1¹ AK052772⁵ AK082099⁵ (see all 10)
tropical clawed frog (Silurana tropicalis)	Str.6364²	--	Transcribed sequence with weak similarity to protein more	81.02(n)	141999050

About this table Species with no ortholog for MKI67

ENSEMBL Gene Tree for MKI67

(Paralogs according to ¹HomoloGene
and ²Ensembl, Pseudogenes according to ³Pseudogene.org)
About This Section

(According to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
About This Section

10/229 NCBI SNPs in MKI67 are shown (see all 229 )
(Click for Applied Biosystems TaqMan ® Genotyping Assay) (see all 137)

AB	SNP ID	Valid	Chr 10 pos	Sequence	Recs	AA Chg	Type	More	Recs	Pop	Total sample	More
AB	Genomic Data				Transcription Data				Allele Frequencies
				--	--	--		--	--			--
	rs8473^1,2	A,C,F,H,O	129789568(-)	`AGAGCA/GAATCT`	1	K/E	mis¹		16	MN EA NA EU WA	2992
	rs997983^1,2	A,C,F,H,O	129800465(-)	`TGTCTA/CTCAGC`	1	I/L	mis¹		17	EA NA MN EU WA	1368
	rs8436^1,2	A,C,F,H,O	129784973(-)	`TTACTC/GTATCC`	1	--	ut3¹ ese³		17	MN NA EU EA WA	1770
	rs2071498^1,2	A,C,F,H	129807550(-)	`TCAGAG/ATGGAA`	1	S/N	mis¹		10	EA EU WA NA	2412
	rs10082391^1,2	A,C,F,H	129791815(+)	`CTTTAC/TCTTCA`	1	D/G	mis¹ ese³		9	EU EA WA NA	910
	rs11106^1,2	A,C,F,H	129789768(-)	`AGTCAC/GTGAGA`	1	T/S	mis¹ ese³		18	MN NA EA EU WA	1754
	rs2071496^1,2	A,C,F,H	129791491(-)	`GGAGAC/GCACGC`	1	T/S	mis¹ ese³		12	EA EU WA NA	2438
--	rs7083622^1,2	A,C,F,H	129793084(+)	`TGGTAG/TTTTTC`	1	T/N	mis¹ ese³		5	EU EA WA NA	484
	rs1050767^1,2	A,C,F,H	129791936(-)	`CAAGCA/CCAAAG`	1	T/P	mis¹		10	MN EU EA WA NA	1098
--	rs7918199^1,2	A,C,F,H	129795419(+)	`CTGCAC/TTGGAG`	1	V/M	mis¹ ese³		9	EU EA WA NA	916

About this table

HapMap Linkage Disequilibrium images for MKI67 (up to first 250kb)

(in which this Gene is Involved, According to OMIM, UniProtKB, Novoseek, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
About This Section

OMIM: 176741

10/98 Novoseek disease relationships for MKI67 gene (see all 98 )

Disease	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
carcinoma	77.13	182	10452505 (5), 19087624 (4), 10697277 (3), 11830925 (3) (see all 99)
tumors	76.01	644	8104388 (4), 14719452 (4), 8912819 (4), 19347828 (4) (see all 99)
dysplasia	71.44	130	10931232 (5), 16948516 (4), 19087624 (4), 11428452 (4) (see all 58)
adenoma	69.02	104	12239922 (4), 11396632 (4), 10452505 (4), 12645814 (3) (see all 60)
metastasis	68.00	103	9537436 (3), 10456281 (3), 12694648 (3), 12479099 (3) (see all 69)
carcinoma squamous cell	66.22	57	17317935 (4), 8879297 (3), 15588557 (3), 15899218 (3) (see all 42)
residual radicular cyst	65.73	1	15610406 (1)
adenocarcinoma	64.03	76	10382939 (6), 12647790 (4), 15638357 (3), 8104388 (2) (see all 49)
breast carcinoma	61.31	31	10692218 (3), 8163266 (3), 8750578 (2), 8100059 (2) (see all 21)
aggressiveness	59.31	8	17713095 (2), 11306504 (2), 18416135 (1), 11598171 (1) (see all 8)

About this table

Human Genome Epidemiology Navigator: MKI67 (8 documents)

(Possibly Related Articles in Doctor's Guide)
About This Section

(in PubMed. Associations of this gene to articles via ¹Novoseek, ²HGNC, ³Entrez Gene, ⁴UniProtKB/Swiss-Prot, ⁵UniProtKB/TrEMBL, ⁶GAD, and/or ⁷PharmGKB)
About This Section

10/1373 PubMed articles for MKI67 gene (see all 1373 ):

A probability-based approach for high-throughput protein phosphorylation analysis and site localization. (PubMed id 16964243)^{3, 4} Beausoleil S.A.... Gygi S.P. (2006)
Phosphoproteome analysis of the human mitotic spindle. (PubMed id 16565220)^{3, 4} Nousiainen M.... Koerner R. (2006)
Ki-67 protein is associated with ribosomal RNA transcription in quiescent and proliferating cells. (PubMed id 16206250)^{2, 3} Bullwinkel J....Scholzen T. (2006)
Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PubMed id 17081983)^{3, 4} Olsen J.V....Mann M. (2006)
Sequential phosphorylation and multisite interactions characterize specific target recognition by the FHA domain of Ki67. (PubMed id 16244663)^{3, 4} Byeon I.-J.... Tsai M.-D. (2005)
Large-scale characterization of HeLa cell nuclear phosphoproteins. (PubMed id 15302935)^{3, 4} Beausoleil S.A....Gygi S.P. (2004)
The DNA sequence and comparative analysis of human chromosome 10. (PubMed id 15164054)^{3, 4} Deloukas P.... Rogers J. (2004)
Structure of human Ki67 FHA domain and its binding to a phosphoprotein fragment from hNIFK reveal unique recognition sites and new views to the structural basis of FHA domain functions. (PubMed id 14659764)^{3, 4} Li H.... Tsai M.-D. (2004)
A novel nucleolar protein, NIFK, interacts with the forkhead associated domain of Ki-67 antigen in mitosis. (PubMed id 11342549)^{3, 4} Takagi M.... Yoneda Y. (2001)
The forkhead-associated domain of Ki-67 antigen interacts with the novel kinesin-like protein Hklp2. (PubMed id 10878014)^{3, 4} Sueishi M.... Yoneda Y. (2000)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
About This Section

Entrez Gene: 4288	HGNC: 7107	AceView: MKI67	Ensembl:ENSG00000148773	euGenes: HUgn4288
ECgene: MKI67	H-InvDB: MKI67

(According to HUGE)
About This Section

(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
ATLAS Chromosomes in Cancer entry for MKI67	Genetics and Cytogenetics in Oncology and Haematology
Wikipedia	http://en.wikipedia.org/wiki/Ki-67_%28Biology%29

Licensable Technologies for MKI67
(Available from WIS Yeda, Salk, Tufts)

About This Section

(Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
Enzo Life Sciences, and/or Tocris Bioscience)
About This Section

Products for MKI67:

TaqMan ® Gene Expression Assays

TaqMan ® Genotyping Assays

Free SNP selection tool

Invitrogen iPath Pathways	Invitrogen BLOCK-iT™ RNAi
Invitrogen Antibodies	Invitrogen Assays
Invitrogen Clones	Invitrogen Q-PCR Products
Invitrogen Human Recombinant Kinases	Invitrogen Custom Antibody and Peptide Service
Invitrogen Proteins / Assays / Screening Services	Search Invitrogen catalog for MKI67-related products

	Millipore Custom Antibody & Bulk Services
	Millipore Preclinical / Clinical Development Services
	Millipore Immunoassay Services
	Millipore Target Screening & Profiling Services

	Predesigned and custom siRNAs for MKI67		Antibodies for MKI67
	Explore super-pooled esiRNAs		Browse proteins at Sigma-Aldrich
	Lentivirus-delivered shRNAs for MKI67		Browse small molecules at Sigma-Aldrich
	"Your Favorite Gene" Pathways		feedback

	Antibodies		Primer Pairs
	Cell Culture Products		ELISAs
	Flow Cytometry Kits		Protease Activity Assays & Reagents
	Cell Selection/Detection Kits & Reagents		ELISA/Assay Development Kits & Reagents
	Multiplex/Array Assay Kits & Reagents		ELISpot Kits & Development Modules
	Recombinant & Natural Proteins

	Recombinant Proteins (MKI67)
	Antibodies (MKI67)
	Chimera RNAi (MKI67)
	Custom Service for Mouse Mab
	Custom Service for Rabbit Pab from Full-length Protein

Search for Antibodies & Assays

	Recombinant Proteins (Ki67)
	Antibodies (Ki67)

Search OriGene for MKI67

Search Tocris compounds for MKI67

Search www.enzolifesicences.com for proteins, assays, substrates, inhibitors & antibodies

Antibodies for MKI67

GeneCards Homepage - Last full update: 2 Jul 2009 Incremental update: 13 Oct 2009

Random Gene From GIFtS :

about GIFtS

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Developed at the Crown Human Genome Center & Weizmann Institute of Science

The GeneCards Human Gene Database: Copyright © 1996-2009, Weizmann Institute of Science. All Rights Reserved.
MKI67 Gene at Home site.
Version 2.41.1
server5.xennexinc.com

MKI67 Gene

protein-coding GIFtS: 62

Aliases &
Descriptions
for MKI67

Summaries
for MKI67

Genomic Location
for MKI67

Proteins
for MKI67

Protein Domains/
Families
for MKI67

Gene Function
for MKI67

Pathways & Interactions
for MKI67

Drugs & Compounds
for MKI67

Transcripts
for MKI67

Expression
for MKI67

Orthologs
for MKI67

Paralogs
for MKI67

SNPs/Variants
for MKI67

Disorders & Mutations
for MKI67

Medical News
for MKI67

Publications
for MKI67

Search for MKI67

Genome Databases showing MKI67

Other Databases showing MKI67

Specialized Databases showing MKI67

Licensable Technologies
for MKI67

Services
for MKI67

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

MKI67 Gene

protein-coding GIFtS: 62

Aliases & Descriptionsfor MKI67

Summariesfor MKI67

Genomic Locationfor MKI67

Proteinsfor MKI67

Protein Domains/Familiesfor MKI67

Gene Functionfor MKI67

Pathways & Interactionsfor MKI67

Drugs & Compoundsfor MKI67

Transcriptsfor MKI67

Expression for MKI67

Orthologsfor MKI67

Paralogsfor MKI67

SNPs/Variantsfor MKI67

Disorders & Mutationsfor MKI67

Medical Newsfor MKI67

Publicationsfor MKI67

Search for MKI67

Genome Databases showing MKI67

Other Databases showing MKI67

Specialized Databases showing MKI67

Licensable Technologiesfor MKI67

Servicesfor MKI67

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Aliases &
Descriptions
for MKI67

Summaries
for MKI67

Genomic Location
for MKI67

Proteins
for MKI67

Protein Domains/
Families
for MKI67

Gene Function
for MKI67

Pathways & Interactions
for MKI67

Drugs & Compounds
for MKI67

Transcripts
for MKI67

Expression
for MKI67

Orthologs
for MKI67

Paralogs
for MKI67

SNPs/Variants
for MKI67

Disorders & Mutations
for MKI67

Medical News
for MKI67

Publications
for MKI67

Licensable Technologies
for MKI67

Services
for MKI67