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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

MKI67 Gene

protein-coding GIFtS: 60
GCID: GC10M129894

antigen identified by monoclonal antibody Ki-67

Explore 249 diseases affiliated with
MKI67 via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Antigen Identified By Monoclonal Antibody Ki-67¹ ²
KIA²
Antigen KI-67²
Proliferation-Related Ki-67 Antigen²

External Ids:	HGNC: 7107¹	Entrez Gene: 4288²	Ensembl: ENSG00000148773⁷	OMIM: 176741⁵	UniProtKB: P46013³

Export aliases for MKI67 gene to outside databases

Previous GC identifers: GC10M128707 GC10M128936 GC10M129824 GC10M129369 GC10M129784 GC10M123469

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for MKI67:

This gene encodes a nuclear protein that is associated with and may be necessary for cellular proliferation.

Alternatively spliced transcript variants have been described. A related pseudogene exists on chromosome X. (provided

by RefSeq, Mar 2009)

UniProtKB/Swiss-Prot: KI67_HUMAN, P46013

Function: Thought to be required for maintaining cell proliferation

Gene Wiki entry for MKI67 (Ki-67)

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000010.10 NC_018921.1 NT_008818.16

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the MKI67 gene promoter:
CHOP-10 TBP Cart-1 CUTL1 Gfi-1 Evi-1
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: MKI67 promoter sequence

Search SABiosciences Chromatin IP Primers for MKI67

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat MKI67

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 10q26.2 Ensembl cytogenetic band: 10q26.2 HGNC cytogenetic band: 10q26.2

MKI67 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
MKI67 gene location

GeneLoc information about chromosome 10 GeneLoc Exon Structure

GeneLoc location for GC10M129894: view genomic region (about GC identifiers)

Start:	129,894,923 bp from pter	End:	129,924,649 bp from pter
Size:	29,727 bases	Orientation:	minus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: KI67_HUMAN, P46013 (See protein sequence)

Recommended Name: Antigen KI-67

Size: 3256 amino acids; 358694 Da

Subunit: Interacts with KIF15. Binds through the FHA domain to MKI67IP

Subcellular location: Nucleus. Nucleus, nucleolus. Chromosome. Note=Predominantly localized in the G1 phase in the

perinucleolar region, in the later phases it is also detected throughout the nuclear interior, being predominantly

localized in the nuclear matrix. In mitosis, it is present on all chromosomes

Developmental stage: Expression of this antigen occurs preferentially during late G1, S, G2 and M phases of the cell

cycle, while in cells in G0 phase the antigen cannot be detected

2 PDB 3D structures from and Proteopedia for MKI67:

1R21 (3D)

2AFF (3D)

Secondary accessions: Q5VWH2

Alternative splicing: 2 isoforms: P46013-1 P46013-2

Explore the universe of human proteins at neXtProt for MKI67: NX_P46013

Post-translational modifications:

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_P46013

MKI67 Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins (2 alternative transcripts):

NP_001139438.1 NP_002408.3

ENSEMBL proteins:

ENSP00000357643 ENSP00000357642

Human Recombinant Protein Products for MKI67:

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	Novus Biologicals MKI67 Protein
	Browse Sino Biological Recombinant Proteins
	Browse ProSpec Recombinant Proteins
	Browse Proteins at Uscn

Gene Ontology (GO): 5/6 cellular component terms (GO ID links to tree view) (see all 6): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0000775	chromosome, centromeric region	IEA	--
GO:0000793	condensed chromosome	IEA	--
GO:0005622	intracellular	--	--
GO:0005634	nucleus	IDA	--
GO:0005730	nucleolus	IDA	--

MKI67 for ontologies About GeneDecksing

MKI67 Antibody Products:

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(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

MKI67 for domains About GeneDecksing

3 InterPro domains/families:

IPR008984 SMAD_FHA_domain

IPR012568 K167R

IPR000253 FHA_dom

Graphical View of Domain Structure for InterPro Entry P46013

ProtoNet protein and cluster: P46013

2 Blocks protein families:

IPB000253 Forkhead-associated (FHA)

IPB012568 K167R

UniProtKB/Swiss-Prot: KI67_HUMAN, P46013

Similarity: Contains 1 FHA domain

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, Sirion Biotech, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, Sirion Biotech, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Molecular Function:

UniProtKB/Swiss-Prot Summary: KI67_HUMAN, P46013

Function: Thought to be required for maintaining cell proliferation

Genatlas biochemistry entry for MKI67:

antigen identified by monoclonal antibody Ki-67 (non histone protein 395/345kDa)

Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005515	protein binding	IPI	11342549
GO:0005524	ATP binding	IEA	--
GO:0008022	protein C-terminus binding	IPI	17577209

MKI67 for ontologies About GeneDecksing

Phenotypes:
3 GenomeRNAi human phenotypes for MKI67:

Increased cell death in breast

Synthetic lethal with Ras

Upregulation of Wnt/beta-caten

Animal Models:

inGenious Targeting Laboratory - Customizable classic, inducible, and humanized mouse model solutions for MKI67

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In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MKI67

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Unified GeneCards pathways About this table

See pathways by source

Super-pathway

contained gene-specific pathways

Cell Cycle / Checkpoint Control

Cell Cycle / Checkpoint Control

1.00

Neuroscience

Neuroscience

1.00

Pathway sources
See GeneCards unified pathways
Show all pathways

2 Cell Signaling Technology (CST) Pathways for MKI67

	Cell Cycle / Checkpoint Control
	Neuroscience

MKI67 for pathways About GeneDecksing

Interactions:

SABiosciences Gene Network Central^TM Interacting Genes and Proteins Network for MKI67

STRING Interaction Network Preview (showing 5 interactants - click image to see 22)

5/28 Interacting proteins for MKI67 (P46013^{2, 3} ENSP00000357643⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 28)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
KIF15	Q9NS87²^,³, ENSP00000324020⁴	MINT-14343 MINT-14342 I2D: score=3 STRING: ENSP00000324020
ABL1	P00519²^,³, ENSP00000361423⁴	MINT-8110467 I2D: score=3 STRING: ENSP00000361423
FYN	P06241²^,³, ENSP00000357656⁴	MINT-8111319 I2D: score=3 STRING: ENSP00000357656
MKI67IP	Q9BYG3²^,³, ENSP00000285814⁴	MINT-50550 I2D: score=2 STRING: ENSP00000285814
SMN1	Q16637²^,³	MINT-8271289 I2D: score=2

About this table

Gene Ontology (GO): 5 biological process terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0006259	DNA metabolic process	IEA	--
GO:0007126	meiosis	IEA	--
GO:0008283	cell proliferation	TAS	17577209
GO:0031100	organ regeneration	IEA	--
GO:0034605	cellular response to heat	IEA	--

MKI67 for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

MKI67 for compounds About GeneDecksing

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for MKI67
10/81 Novoseek chemical compound relationships for MKI67 gene (see all 81) About this table

Compound	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
paraffin	77.8	101	8163266 (3), 7496600 (2), 9392055 (2), 1484317 (2) (see all 92)
progesterone	68.2	129	16972993 (4), 7865851 (3), 15377824 (3), 15979129 (3) (see all 99)
estrogen	62.6	124	16972993 (4), 15979129 (3), 8137282 (2), 7865851 (2) (see all 98)
bromodeoxyuridine	48.4	60	7855002 (7), 10730321 (3), 9589362 (3), 1670579 (2) (see all 29)
hematoxylin	47.7	11	10410171 (1), 18083370 (1), 14707453 (1), 16425381 (1) (see all 11)
vegf	47.3	92	15918184 (5), 19434817 (4), 15133868 (4), 15623373 (4) (see all 51)
norcantharidin	47.1	8	15567755 (4), 16784656 (2), 17287171 (1)
2-aminoacridone	34.6	2	7997128 (1), 7868749 (1)
pyronin y	32.5	2	14976368 (1), 15277701 (1)
tamoxifen	29.8	35	16972993 (4), 9499446 (4), 10542936 (4), 15289830 (3) (see all 11)

1 PharmGKB related drug/compound annotation for MKI67 gene About this table

Drug/compound	PharmGKB Annotation
fulvestrant	DL

Search CenterWatch for drugs/clinical trials and news about MKI67 / KI67

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, Sirion Biotech, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for MKI67 gene (2 alternative transcripts):

NM_001145966.1 NM_002417.4

Unigene Clusters for MKI67:

Antigen identified by monoclonal antibody Ki-67

Hs.80976 [show with all ESTs], Hs.689823

Unigene Representative Sequences: X65550, AJ567755

5 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000368654(uc001lke.3) ENST00000368653(uc001lkf.3 uc009yav.1 uc009yaw.1)

ENST00000464771 ENST00000484853 ENST00000478293

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Additional cDNA sequence: AJ567755.1

15 DOTS entries:

DT.100641296 DT.91752801 DT.218496 DT.100641976 DT.95335759 DT.91888764 DT.95148338 DT.95231686

DT.99972196 DT.100641975 DT.101975754 DT.92327801 DT.95289497 DT.95335757 DT.97848370

24/374 AceView cDNA sequences (see all 374):

CR607300 BX493042 BM682971 AI743928 BG256413 W87907 AA262266 BU855841

AW135734 BU431247 BU171176 BG285094 BQ005613 BX473776 BF968450 AA778194

CF136127 BF982674 BM796240 AI696794 BF095018 AA236631 BM455229 BG389162

GeneLoc Exon Structure

5/8 Alternative Splicing Database (ASD) splice patterns (SP) for MKI67 (see all 8) About this scheme

ExUns:	1	^	2a	·	2b	^	3	^	4	^	5	^	6	^	7a	·	7b	^	8a	·	8b	^	9	^	10a	·	10b	^	11	^	12	^	13a	·	13b	^	14	^	15a	·	15b	^	16a	·	16b	·	16c	^	17
SP1:							-		-						-		-		-		-														-
SP2:
SP3:
SP4:
SP5:

ECgene alternative splicing isoforms for MKI67

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

MKI67 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: AGGGCCGACT

About this image

MKI67 expression in embryonic tissues and stem cells
Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

2 LifeMap In Vivo Development Anatomical Compartments/Cells

Tissue

Anatomical Compartment

Cell

Category (developmental path)

Liver

Mesoblastic Supporting Stroma

Submesothelial Cells

Liver

Kidney

S-shaped Body

Kidney Endothelial Cells

Endothelium

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

Stem Cell Differentiation: 3 LifeMap Cells

Name

Category

Adult human kidney epithelial cells (Primary Cell)

Kidney

Neurospheres (Generation of neuros...)

Pancreatic endoderm-like cells (Serum-free protocol ...)

See MKI67 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for MKI67

SOURCE GeneReport for Unigene clusters: Hs.80976 Hs.689823

SABiosciences Expression via Pathway-Focused PCR Arrays including MKI67 (see all 7):

Lung Cancer in human mouse rat

Cell Cycle in human mouse rat

Breast Cancer in human mouse rat

Cancer PathwayFinder in human mouse rat

Lymphoma in human mouse rat

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		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat MKI67

In Situ
Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MKI67

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of chordates.

Orthologs for MKI67 gene from 5/16 species (see all 16) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
mouse (Mus musculus)	Mammalia	Mki67^{1 , 5}	antigen identified by monoclonal antibody Ki 67^{1, 5}	61.87(n)¹ 44.93(a)¹		7 (81.32 cM)⁵ 17345¹ NM_001081117.2¹ NP_001074586.2¹ 135689788⁵
chicken (Gallus gallus)	Aves	GGA.52640⁶ GGA.48592⁶	Uncharacterized protein	45(a) 22(a)	many → 1 many → 1	6(35361533-35366750) 6(35372648-35374312)
lizard (Anolis carolinensis)	Reptilia	MKI67⁶	--	25(a)	1 ↔ 1	3(54036220-54074342)
tropical clawed frog (Xenopus tropicalis)	Amphibia	Str.6364²	Transcribed sequence with weak similarity to protein more	81.02(n)		141999050
zebrafish (Danio rerio)	Actinopterygii	CR848037.2⁶	--	16(a)	1 ↔ 1	12(11446922-11459480)

ENSEMBL Gene Tree for MKI67 (if available)
TreeFam Gene Tree for MKI67 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for MKI67 gene

MKI67 for paralogs About GeneDecksing

3 Pseudogenes.org Pseudogenes for MKI67
PGOHUM00000238651 PGOHUM00000240074 PGOHUM00000241265

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 10 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs187754539^1,2		--	129894442(+)	`TCCCTC/TCCTCC`	2	--	int¹		0	--	--	--	--
rs35744562^1,2	C	--	129894519(+)	`TCAGGACTA/- ACTGA`	2	--	int¹		1		NA	2
rs66597739^1,2	C	--	129894522(+)	`GGACT-/AACT GACCT`	2	--	int¹		1		NA	2
rs2798667^1,2	H	--	129894773(+)	`ATGACT/CTATTG`	2	--	int¹		4		NS EA	420
rs147643964^1,2		--	129894776(+)	`ACTTAC/TTGGCC`	2	--	int¹		0	--	--	--	--
rs145973184^1,2	C	--	129894816(+)	`CTTGT-/AGAAAT`	2	--	int¹		0	--	--	--	--
rs2782877^1,2	C,F,H	--	129894860(-)	`GACAGG/ACCAGT`	2	--	int¹		15		NS EA NA	1666
rs192590154^1,2		--	129894954(+)	`TATTGA/GACATC`	2	--	ut3¹		0	--	--	--	--
rs8436^1,2	C,F,O,A,H	--	129894983(-)	`TTACTC/GTATCC`	2	--	ut3¹ ese³		20		MN NA NS EA WA	1718
rs184361636^1,2		--	129894988(+)	`GAGTAA/CCCAGG`	2	--	ut3¹		0	--	--	--	--

HapMap Linkage Disequilibrium report for MKI67 (129894923 - 129924649 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 2 variations for MKI67
2 CNVs: 48457 47892

SABiosciences Cancer Mutation PCR Assays

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

MKI67 for disorders           About GeneDecksing

OMIM gene information: 176741    OMIM disorders: --

20/249 diseases for MKI67 (see all 249):    About MalaCards

estrogen-receptor positive breast cancer malignant fibrous histiocytoma squamous cell carcinoma smooth muscle tumor

fibrous histiocytoma middle ear cholesteatoma diffuse large b-cell lymphoma ovarian stromal hyperthecosis

langerhans-cell histiocytosis soft tissue sarcoma cervical intraepithelial neoplasia retinol binding protein

dysembryoplastic neuroepithelial tumor age related macular degeneration dna topoisomerase ii gastrointestinal stromal tumor

dna topoisomerase i fallopian tube carcinoma non-small cell lung carcinoma actinic cheilitis

4 diseases from the University of Copenhagen DISEASES database for MKI67:

Carcinoma Adenoma Meningioma Breast cancer

10/98 Novoseek disease relationships for MKI67 gene (see all 98) About this table

Disease	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
carcinoma	77.5	197	10452505 (5), 19087624 (4), 19447418 (3), 10697277 (3) (see all 99)
tumors	76.5	688	8104388 (4), 14719452 (4), 19784424 (4), 15581977 (4) (see all 99)
dysplasia	71.2	136	10931232 (5), 16948516 (4), 19087624 (4), 11428452 (4) (see all 60)
metastasis	69.2	116	9537436 (3), 10456281 (3), 10854531 (3), 12479099 (3) (see all 76)
adenoma	68.5	106	12239922 (4), 11396632 (4), 10452505 (4), 12645814 (3) (see all 61)
carcinoma squamous cell	67.5	62	17317935 (4), 8879297 (3), 15588557 (3), 15899218 (3) (see all 46)
adenocarcinoma	65.1	83	10382939 (6), 12647790 (4), 15638357 (3), 8104388 (2) (see all 54)
residual radicular cyst	63.7	1	15610406 (1)
breast carcinoma	61.5	33	10692218 (3), 8163266 (3), 8750578 (2), 8100059 (2) (see all 23)
pituitary adenoma nonfunctioning	60.6	3	14567602 (2), 9030353 (1)

Human Genome Epidemiology (HuGE) Navigator: MKI67 (21 documents)

Export disorders for MKI67 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

PubMed articles for MKI67 gene, integrated from 9 sources (see all 1689):
(articles sorted by number of sources associating them with MKI67)

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A probability-based approach for high-throughput protein phosphorylation analysis and site localization. (PubMed id 16964243)^{1, 2} Beausoleil S.A.... Gygi S.P. (2006)
Ki-67 protein is associated with ribosomal RNA transcription in quiescent and proliferating cells. (PubMed id 16206250)^{1, 3} Bullwinkel J....Scholzen T. (2006)
Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PubMed id 17081983)^{1, 2} Olsen J.V....Mann M. (2006)
Sequential phosphorylation and multisite interactions characterize specific target recognition by the FHA domain of Ki67. (PubMed id 16244663)^{1, 2} Byeon I.-J.... Tsai M.-D. (2005)
The DNA sequence and comparative analysis of human chromosome 10. (PubMed id 15164054)^{1, 2} Deloukas P.... Rogers J. (2004)
Structure of human Ki67 FHA domain and its binding to a phosphoprotein fragment from hNIFK reveal unique recognition sites and new views to the structural basis of FHA domain functions. (PubMed id 14659764)^{1, 2} Li H.... Tsai M.-D. (2004)
A novel nucleolar protein, NIFK, interacts with the forkhead associated domain of Ki-67 antigen in mitosis. (PubMed id 11342549)^{1, 2} Takagi M.... Yoneda Y. (2001)
The forkhead-associated domain of Ki-67 antigen interacts with the novel kinesin-like protein Hklp2. (PubMed id 10878014)^{1, 2} Sueishi M.... Yoneda Y. (2000)
The cell proliferation-associated antigen of antibody Ki-67: a very large, ubiquitous nuclear protein with numerous repeated elements, representing a new kind of cell cycle-maintaining proteins. (PubMed id 8227122)^{1, 2} Schlueter C.... Gerdes J. (1993)
Assignment of the gene(s) involved in the expression of the proliferation-related Ki-67 antigen to human chromosome 10. (PubMed id 2571566)^{1, 3} Schonk D.M....Ramaekers F.C. (1989)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Disorders
Free Text

Query String		PubMed OMIM NCBI Bookshelf
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(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 4288	HGNC: 7107	AceView: MKI67	Ensembl:ENSG00000148773	euGenes: HUgn4288
ECgene: MKI67	H-InvDB: MKI67

(According to HUGE)
About This Section

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
PharmGKB entry for MKI67	Pharmacogenomics, SNPs, Pathways
ATLAS Chromosomes in Cancer entry for MKI67	Genetics and Cytogenetics in Oncology and Haematology
Wikipedia	http://en.wikipedia.org/wiki/Ki-67_%28Biology%29

Intellectual Property for MKI67 gene
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Patent Information for MKI67 gene:
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antigen identified by monoclonal antibody Ki-67

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MKI67 Gene

antigen identified by monoclonal antibody Ki-67

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