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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

MKI67 Gene

protein-coding   GIFtS: 62
GCID: GC10M129894

Antigen Identified By Monoclonal Antibody Ki-67

Microbiology & Infectious Diseases Congress
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Antigen Identified By Monoclonal Antibody Ki-671 2
KIA2
MIB-12
Antigen KI-672
Proliferation-Related Ki-67 Antigen2

External Ids:    HGNC: 71071   Entrez Gene: 42882   Ensembl: ENSG000001487737   OMIM: 1767415   UniProtKB: P460133   

Export aliases for MKI67 gene to outside databases

Previous GC identifers: GC10M128707 GC10M128936 GC10M129824 GC10M129369 GC10M129784 GC10M123469


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for MKI67 Gene:
This gene encodes a nuclear protein that is associated with and may be necessary for cellular proliferation.
Alternatively spliced transcript variants have been described. A related pseudogene exists on chromosome X.
(provided by RefSeq, Mar 2009)

GeneCards Summary for MKI67 Gene: 
MKI67 (antigen identified by monoclonal antibody Ki-67) is a protein-coding gene. Diseases associated with MKI67 include ovarian stromal hyperthecosis, and necrotizing sialometaplasia, and among its related super-pathways are DNA Damage. GO annotations related to this gene include protein C-terminus binding and ATP binding.

UniProtKB/Swiss-Prot: KI67_HUMAN, P46013
Function: Thought to be required for maintaining cell proliferation

Gene Wiki entry for MKI67 (Ki-67) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000010.10  NT_008818.16  NC_018921.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the MKI67 gene promoter:
         CHOP-10   TBP   Cart-1   CUTL1   Gfi-1   Evi-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidMKI67 promoter sequence
   Search SABiosciences Chromatin IP Primers for MKI67

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat MKI67


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 10q26.2   Ensembl cytogenetic band:  10q26.2   HGNC cytogenetic band: 10q26.2

MKI67 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
MKI67 gene location

GeneLoc information about chromosome 10         GeneLoc Exon Structure

GeneLoc location for GC10M129894:  view genomic region     (about GC identifiers)

Start:
129,894,923 bp from pter      End:
129,924,649 bp from pter
Size:
29,727 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: KI67_HUMAN, P46013 (See protein sequence)
Recommended Name: Antigen KI-67  
Size: 3256 amino acids; 358694 Da
Subunit: Interacts with KIF15. Binds through the FHA domain to MKI67IP. Part of a complex composed at least of
ASCL2, C11orf30/EMSY, HCFC1, HSPA8, KIAA1967, MATR3, MKI67, RBBP5, TUBB2A, WDR5 and ZNF335; this complex may have
a histone H3-specific methyltransferase activity
Subcellular location: Nucleus. Nucleus, nucleolus. Chromosome. Note=Predominantly localized in the G1 phase in the
perinucleolar region, in the later phases it is also detected throughout the nuclear interior, being
predominantly localized in the nuclear matrix. In mitosis, it is present on all chromosomes
Developmental stage: Expression of this antigen occurs preferentially during late G1, S, G2 and M phases of the
cell cycle, while in cells in G0 phase the antigen cannot be detected
2 PDB 3D structures from and Proteopedia for MKI67:
1R21 (3D)        2AFF (3D)    
Secondary accessions: Q5VWH2
Alternative splicing: 2 isoforms:  P46013-1   P46013-2   

Explore the universe of human proteins at neXtProt for MKI67: NX_P46013

Explore proteomics data for MKI67 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_P46013

  • MKI67 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    MKI67 Protein Expression
    REFSEQ proteins (2 alternative transcripts): 
    NP_001139438.1  NP_002408.3  

    ENSEMBL proteins: 
     ENSP00000357642   ENSP00000357643  

    Human Recombinant Protein Products for MKI67: 
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    Browse ProSpec Recombinant Proteins
    Browse Proteins at Cloud-Clone Corp. 

    Gene Ontology (GO): 5/7 cellular component terms (GO ID links to tree view) (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000775chromosome, centromeric region IEA--
    GO:0000793condensed chromosome IEA--
    GO:0005622intracellular ----
    GO:0005634nucleus IDA--
    GO:0005730nucleolus IDA--

    MKI67 for ontologies           About GeneDecksing



    MKI67 Antibody Products: 
    EMD Millipore Mono- and Polyclonal Antibodies for the study of MKI67
    R&D Systems Antibodies for MKI67 (Ki-67/MKI67)
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    Abcam antibodies for MKI67
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    LSBio Antibodies in human, mouse, rat for MKI67 

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    3 InterPro protein domains:
     IPR008984 SMAD_FHA_domain
     IPR012568 K167R
     IPR000253 FHA_dom

    Graphical View of Domain Structure for InterPro Entry P46013

    ProtoNet protein and cluster: P46013

    2 Blocks protein domains:
    IPB000253 Forkhead-associated (FHA)
    IPB012568 K167R


    UniProtKB/Swiss-Prot: KI67_HUMAN, P46013
    Similarity: Contains 1 FHA domain


    MKI67 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: KI67_HUMAN, P46013
    Function: Thought to be required for maintaining cell proliferation

         Genatlas biochemistry entry for MKI67:
    antigen identified by monoclonal antibody Ki-67 (non histone protein 395/345kDa)

         Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding IPI11342549
    GO:0005524ATP binding IEA--
    GO:0008022protein C-terminus binding IPI17577209
         
    MKI67 for ontologies           About GeneDecksing


    Phenotypes:
         3 GenomeRNAi human phenotypes for MKI67:
     Increased cell death in breast  Synthetic lethal with Ras  Upregulation of Wnt/beta-caten 

    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for MKI67 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for MKI67

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for MKI67 
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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for MKI67 About                                                                                                See pathways by source

    SuperPathContained pathways About
    1DNA Damage
    Cell Cycle / Checkpoint Control0.32
    2Neuroscience
    Neuroscience

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    2 Cell Signaling Technology (CST) Pathways for MKI67
        Cell Cycle / Checkpoint Control
    Neuroscience




    MKI67 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for MKI67

    STRING Interaction Network Preview (showing 5 interactants - click image to see 22)

    5/28 Interacting proteins for MKI67 (P460132, 3 ENSP000003576434) via UniProtKB, MINT, STRING, and/or I2D (see all 28)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    KIF15Q9NS872, 3, ENSP000003240204MINT-14343 MINT-14342 I2D: score=3 STRING: ENSP00000324020
    ABL1P005192, 3, ENSP000003614234MINT-8110467 I2D: score=3 STRING: ENSP00000361423
    FYNP062412, 3, ENSP000003576564MINT-8111319 I2D: score=3 STRING: ENSP00000357656
    MKI67IPQ9BYG32, 3, ENSP000002858144MINT-50550 I2D: score=2 STRING: ENSP00000285814
    SMN1Q166372, 3MINT-8271289 I2D: score=2 
    About this table

    Gene Ontology (GO): 5 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006259DNA metabolic process IEA--
    GO:0007126meiosis IEA--
    GO:0008283cell proliferation TAS17577209
    GO:0031100organ regeneration IEA--
    GO:0034605cellular response to heat IEA--

    MKI67 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    MKI67 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for MKI67 (KI67)

    10/81 Novoseek inferred chemical compound relationships for MKI67 gene (see all 81)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    paraffin 77.8 101 8163266 (3), 7496600 (2), 9392055 (2), 1484317 (2) (see all 92)
    progesterone 68.2 129 16972993 (4), 7865851 (3), 15377824 (3), 15979129 (3) (see all 99)
    estrogen 62.6 124 16972993 (4), 15979129 (3), 8137282 (2), 7865851 (2) (see all 98)
    bromodeoxyuridine 48.4 60 7855002 (7), 10730321 (3), 9589362 (3), 1670579 (2) (see all 29)
    hematoxylin 47.7 11 10410171 (1), 18083370 (1), 14707453 (1), 16425381 (1) (see all 11)
    vegf 47.3 92 15918184 (5), 19434817 (4), 15133868 (4), 15623373 (4) (see all 51)
    norcantharidin 47.1 8 15567755 (4), 16784656 (2), 17287171 (1)
    2-aminoacridone 34.6 2 7997128 (1), 7868749 (1)
    pyronin y 32.5 2 14976368 (1), 15277701 (1)
    tamoxifen 29.8 35 16972993 (4), 9499446 (4), 10542936 (4), 15289830 (3) (see all 11)

    1 PharmGKB related drug/compound annotation for MKI67 gene    About this table
    Drug/compound PharmGKB Annotation
    fulvestrant

    Search CenterWatch for drugs/clinical trials and news about MKI67 / KI67

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for MKI67 gene (2 alternative transcripts): 
    NM_001145966.1  NM_002417.4  

    Unigene Clusters for MKI67:

    Antigen identified by monoclonal antibody Ki-67
    Hs.80976  [show with all ESTs], Hs.689823
    Unigene Representative Sequences: X65550, AJ567755
    5 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000368653(uc001lkf.3 uc009yav.1 uc009yaw.1) ENST00000368654(uc001lke.3)
    ENST00000464771 ENST00000484853 ENST00000478293
    Congresses - knowledge worth sharing:  
    European Congress of Clinical Microbiology and Infectious Diseases (ECCMID) 10 - 13 May 2014

    miRNA
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    Inhib. RNA
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      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat MKI67
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat MKI67

    Additional mRNA sequence: AJ567755.1 

    15 DOTS entries:

    DT.100641296  DT.91752801  DT.218496  DT.100641976  DT.95335759  DT.91888764  DT.95148338  DT.95231686 
    DT.99972196  DT.100641975  DT.101975754  DT.92327801  DT.95289497  DT.95335757  DT.97848370 

    24/374 AceView cDNA sequences (see all 374):

    AW502198 BU855841 BU171176 BX493042 AW206195 BU154307 BM476598 AA236631 
    CF136127 BF095018 AI696794 CR607300 BX473776 AJ567755 BM455791 BM682971 
    BQ014072 BU431247 BX118911 BQ005613 BU619546 AL556595 BQ944222 BP365434 

    GeneLoc Exon Structure

    5/8 Alternative Splicing Database (ASD) splice patterns (SP) for MKI67 (see all 8)    About this scheme

    ExUns: 1 ^ 2a · 2b ^ 3 ^ 4 ^ 5 ^ 6 ^ 7a · 7b ^ 8a · 8b ^ 9 ^ 10a · 10b ^ 11 ^ 12 ^ 13a · 13b ^ 14 ^ 15a · 15b ^ 16a · 16b · 16c ^ 17
    SP1:                    -     -                 -     -     -     -                                         -                                             
    SP2:                                                                                                                                                      
    SP3:                                                                                                                                                      
    SP4:                                                                                                                                                      
    SP5:                                                                                                                                                      


    ECgene alternative splicing isoforms for MKI67

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    MKI67 expression in normal human tissues (normalized intensities)      MKI67 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: AGGGCCGACT
    MKI67 Expression
    About this image


    MKI67 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/39 selected tissues (see all 39) fully expand
     
     Brain (Nervous System)    fully expand to see all 16 entries
             Choroid Plexus Progenitor Cells Choroid Plexus
             Thalamus
             Olfactory Bulb   
     
     Blood (Hematopoietic System)    fully expand to see all 5 entries
             Hematopoietic Stem Cells Hematopoietic Bone Marrow
             Umbilical cord blood-derived mesenchymal stem cells
             mouse/organ system/cardiovascular system   
     
     Neural Tube (Nervous System)    fully expand to see all 5 entries
             Telencephalon
     
     Heart (Cardiovascular System)    fully expand to see all 4 entries
             Cardiac progenitor cells (Sca1+)
             heart/atrium   
     
     Hair (Integumentary System)    fully expand to see all 4 entries
             Sebocyte Progenitor Cells Sebaceous Gland
             mouse/organ system/integumental system   

    See MKI67 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for MKI67

    SOURCE GeneReport for Unigene clusters: Hs.80976 Hs.689823
        SABiosciences Expression via Pathway-Focused PCR Arrays including MKI67 (see all 7): 
              Lung Cancer in human mouse rat
              Cell Cycle in human mouse rat
              Breast Cancer in human mouse rat
              Cancer PathwayFinder in human mouse rat
              Lymphoma in human mouse rat

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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MKI67

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of chordates.

    Orthologs for MKI67 gene from 5/11 species (see all 11)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Mki671 , 5 antigen identified by monoclonal antibody Ki 671, 5 61.87(n)1
    44.93(a)1
      7 (81.32 cM)5
    173451  NM_001081117.21  NP_001074586.21 
     1356897885 
    chicken
    (Gallus gallus)
    Aves MKI676
    Uncharacterized protein
    14(a)
    1 ↔ 1
    6(32890714-32910556)
    lizard
    (Anolis carolinensis)
    Reptilia MKI676
    Uncharacterized protein
    23(a)
    1 ↔ 1
    3(54033699-54074342)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia Str.63642 Transcribed sequence with weak similarity to protein more 81.02(n)    141999050 
    zebrafish
    (Danio rerio)
    Actinopterygii MKI676
    antigen identified by monoclonal antibody Ki-67
    19(a)
    1 ↔ 1
    12(11445703-11460368)


    ENSEMBL Gene Tree for MKI67 (if available)
    TreeFam Gene Tree for MKI67 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for MKI67 gene

    MKI67 for paralogs           About GeneDecksing


    3 Pseudogenes.org Pseudogenes for MKI67
    PGOHUM00000238651 PGOHUM00000240074 PGOHUM00000241265


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/1147 SNPs in MKI67 are shown (see all 1147)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 10 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1877545391,2
    --129894442(+) TCCCTC/TCCTCC 2 -- int10--------
    rs665977391,2
    C--129894522(+) GGACT-/AACT  
            
    GACCT
    2 -- int11Minor allele frequency- AACT:0.00NA 2
    rs27986671,2
    H--129894773(+) ATGACT/CTATTG 2 -- int14Minor allele frequency- C:0.00NS EA 420
    rs1476439641,2
    --129894776(+) ACTTAC/TTGGCC 2 -- int10--------
    rs1459731841,2
    C--129894816(+) CTTGT-/AGAAAT 2 -- int10--------
    rs27828771,2
    C,F,H--129894860(-) GACAGG/ACCAGT 2 -- int115Minor allele frequency- A:0.05NS EA NA 1666
    rs1925901541,2
    --129894954(+) TATTGA/GACATC 2 -- ut310--------
    rs84361,2
    C,F,O,A,H--129894983(-) TTACTC/GTATCC 2 -- ut31 ese320Minor allele frequency- G:0.33MN NA NS EA WA 1718
    rs1843616361,2
    C--129894988(+) GAGTAA/CCCAGG 2 -- ut310--------
    rs73481,2
    C,F--129894998(-) GACTGC/TATTTC 2 -- ut3113Minor allele frequency- T:0.29MN NA EA WA 954

    HapMap Linkage Disequilibrium report for MKI67 (129894923 - 129924649 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 7 variations for MKI67:    About this table     
    Variant IDTypeSubtypePubMed ID
    esv2676916CNV Deletion23128226
    esv2660735CNV Deletion23128226
    esv2743339CNV Deletion23290073
    nsv467481CNV Loss19166990
    dgv52n21CNV Loss19592680
    esv34105CNV Loss18971310
    nsv523484CNV Loss19592680

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 176741    OMIM disorders: --

    20/215 diseases for MKI67 (see all 215):    About MalaCards
    ovarian stromal hyperthecosis    necrotizing sialometaplasia    brain ependymoma    intraocular melanoma
    unilateral retinoblastoma    bladder adenocarcinoma    clear cell meningioma    ameloblastic carcinoma
    sclerosing adenosis of breast    sebaceous adenoma    cellular leiomyoma    pulmonary vein stenosis
    soft tissue sarcoma    gastrointestinal neuroendocrine tumor    ovarian carcinosarcoma    esophagus adenocarcinoma
    phyllode tumor    posterior uveal melanoma    adenosarcoma    parametritis

    3 diseases from the University of Copenhagen DISEASES database for MKI67:
    Carcinoma     Adenoma     Breast cancer

    MKI67 for disorders           About GeneDecksing


    Congresses - knowledge worth sharing:  
    Alzheimer's & Parkinson's Diseases Congress (ADPD) 18 - 22 March 2015

    10/98 Novoseek inferred disease relationships for MKI67 gene (see all 98)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    carcinoma 77.5 197 10452505 (5), 19087624 (4), 19447418 (3), 10697277 (3) (see all 99)
    tumors 76.5 688 8104388 (4), 14719452 (4), 19784424 (4), 15581977 (4) (see all 99)
    dysplasia 71.2 136 10931232 (5), 16948516 (4), 19087624 (4), 11428452 (4) (see all 60)
    metastasis 69.2 116 9537436 (3), 10456281 (3), 10854531 (3), 12479099 (3) (see all 76)
    adenoma 68.5 106 12239922 (4), 11396632 (4), 10452505 (4), 12645814 (3) (see all 61)
    carcinoma squamous cell 67.5 62 17317935 (4), 8879297 (3), 15588557 (3), 15899218 (3) (see all 46)
    adenocarcinoma 65.1 83 10382939 (6), 12647790 (4), 15638357 (3), 8104388 (2) (see all 54)
    residual radicular cyst 63.7 1 15610406 (1)
    breast carcinoma 61.5 33 10692218 (3), 8163266 (3), 8750578 (2), 8100059 (2) (see all 23)
    pituitary adenoma nonfunctioning 60.6 3 14567602 (2), 9030353 (1)

    Genetic Association Database (GAD): MKI67
    Human Genome Epidemiology (HuGE) Navigator: MKI67 (21 documents)

    Export disorders for MKI67 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for MKI67 gene, integrated from 9 sources (see all 1735):
    (articles sorted by number of sources associating them with MKI67)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Evaluation of candidate stromal epithelial cross-talk genes identifies association between risk of serous ovarian cancer and TERT, a cancer susceptibility 'hot-spot'. (PubMed id 20628624)1, 4 Johnatty S.E.... . (2010)
    2. Investigation of genetic susceptibility factors for h uman longevity - A targeted nonsynonymous SNP study. (PubMed id 20800603)1, 4 Flachsbart F....Nebel A. (2010)
    3. Gene variants associated with ischemic stroke: the cardiovascular health study. (PubMed id 19023099)1, 4 Luke M.M....Psaty B.M. (2009)
    4. Novel susceptibility loci for second primary tumors/r ecurrence in head and neck cancer patients: large-scale evaluation of genetic v ariants. (PubMed id 19584075)1, 4 Wu X....Hong W.K. (2009)
    5. Fulfilling the promise of personalized medicine? Syst ematic review and field synopsis of pharmacogenetic studies. (PubMed id 19956635)1, 4 Holmes M.V....Casas J.P. (2009)
    6. Association of gene variants with incident myocardial infarction in the Cardiovascular Health Study. (PubMed id 17975119)1, 4 Shiffman D....Psaty B.M. (2008)
    7. Genome-wide association with select biomarker traits in the Framingham Heart Study. (PubMed id 17903293)1, 4 Benjamin E.J....Vasan R.S. (2007)
    8. A probability-based approach for high-throughput protein phosphorylation analysis and site localization. (PubMed id 16964243)1, 2 Beausoleil S.A.... Gygi S.P. (2006)
    9. Ki-67 protein is associated with ribosomal RNA transcription in quiescent and proliferating cells. (PubMed id 16206250)1, 3 Bullwinkel J....Scholzen T. (2006)
    10. A scan of chromosome 10 identifies a novel locus showing strong association with late-onset Alzheimer disease. (PubMed id 16385451)1, 4 Grupe A....Goate A. (2006)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 4288 HGNC: 7107 AceView: MKI67 Ensembl:ENSG00000148773 euGenes: HUgn4288
    ECgene: MKI67 H-InvDB: MKI67

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for MKI67 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for MKI67 Genetics and Cytogenetics in Oncology and Haematology
    Wikipedia http://en.wikipedia.org/wiki/Ki-67_%28Biology%29

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for MKI67 gene:
    Search GeneIP for patents involving MKI67

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    About This Section

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