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GIFtS

MIXL1 Gene

protein-coding   GIFtS: 49
GCID: GC01P226411

Mix paired-like homeobox

(Previous names: Mix1 homeobox (Xenopus laevis)-like 1, Mix1 homeobox-like...)
 Explore 6 diseases affiliated with
MIXL1 via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for MIXL1    

Aliases
for MIXL1 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
Mix Paired-Like Homeobox1 2     MIX1 Homeobox-Like Protein 12 3
MIXL1 2 3 5     MIX2 5
MILD11 2     Mix1 Homeobox (Xenopus Laevis)-Like 11
Homeodomain Protein MIX2 3     Mix1 Homeobox-Like 1 (Xenopus Laevis)1
Mix.1 Homeobox-Like Protein2 3     Homeobox Protein MIXL12
HMix1     Mix-Like Homeobox Protein 12

External Ids:    HGNC: 133631   Entrez Gene: 838812   Ensembl: ENSG000001851557   OMIM: 6098525   UniProtKB: Q9H2W23   

Export aliases for MIXL1 gene to outside databases

Previous GC identifers: GC01P222227 GC01P222818 GC01P223386 GC01P222718 GC01P224478 GC01P196928


Summaries
for MIXL1 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for MIXL1:
Homeodomain proteins, such as MIXL1, are transcription factors that regulate cell fate during development (Hart et al.,
2005 (PubMed 15982639)).(supplied by OMIM, Mar 2008)

UniProtKB/Swiss-Prot: MIXL1_HUMAN, Q9H2W2
Function: Transcription factor that play a central role in proper axial mesendoderm morphogenesis and endoderm
formation. Required for efficient differentiation of cells from the primitive streak stage to blood, by acting early
in the recruitment and/or expansion of mesodermal progenitors to the hemangioblastic and hematopoietic lineages. Also
involved in the morphogenesis of the heart and the gut during embryogenesis. Acts as a negative regulator of brachyury
expression (By similarity)




Genomic Views
for MIXL1 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000001.10  NC_018912.1  NT_167186.1  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the MIXL1 gene promoter:
         C/EBPbeta   Nkx2-5   POU6F1 (c2)   CUTL1   PPAR-gamma1   POU2F1   POU2F1a   POU2F1b   POU2F1c   PPAR-gamma2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: MIXL1 promoter sequence
   Search SABiosciences Chromatin IP Primers for MIXL1

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat MIXL1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1q42.12   Ensembl cytogenetic band:  1q42.12   HGNC cytogenetic band: 1q42.12

MIXL1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
MIXL1 gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01P226411:  view genomic region     (about GC identifiers)

Start:
 226,411,319 bp from pter      End:
 226,414,785 bp from pter
Size:
 3,467 bases      Orientation:
 plus strand

Proteins
for MIXL1 gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: MIXL1_HUMAN, Q9H2W2 (See protein sequence)
Recommended Name: Homeobox protein MIXL1  
Size: 232 amino acids; 24659 Da
Subcellular location: Nucleus

Explore the universe of human proteins at neXtProt for MIXL1: NX_Q9H2W2

Post-translational modifications:

  • Phosphorylated at multiple sites1
  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q9H2W2

    • MIXL1 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins: NP_114150.1  
    ENSEMBL proteins: 
     ENSP00000442439   ENSP00000355775  

    Human Recombinant Protein Products: 
    Browse Purified and Recombinant Proteins at EMD Millipore
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    OriGene Protein Over-expression Lysate: MIXL1
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    Novus Biologicals MIXL1 Protein
    Browse Sino Biological Recombinant Proteins
    Browse ProSpec Recombinant Proteins
    Uscn Proteins for MIXL1

    Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000790nuclear chromatin ISS--
    GO:0005634nucleus ----


    MIXL1 for ontologies           About GeneDecksing



    MIXL1 Antibody Products: 
    EMD Millipore Mono- and Polyclonal Antibodies for the study of MIXL1
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    Uscn Antibodies for MIXL1
    Search ThermoFisher Antibodies for MIXL1

    Assay Products for MIXL1: 
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    Uscn ELISAs and CLIAs for MIXL1

    Protein Domains /
    Families
    for MIXL1 gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    MIXL1 for domains           About GeneDecksing

    3 InterPro domains/families:
     IPR017970 Homeobox_CS
     IPR001356 Homeodomain
     IPR009057 Homeodomain-like

    Graphical View of Domain Structure for InterPro Entry Q9H2W2

    ProtoNet protein and cluster: Q9H2W2

    UniProtKB/Swiss-Prot: MIXL1_HUMAN, Q9H2W2
    Similarity: Belongs to the paired homeobox family
    Similarity: Contains 1 homeobox DNA-binding domain


    Function
    for MIXL1 gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: MIXL1_HUMAN, Q9H2W2
    Function: Transcription factor that play a central role in proper axial mesendoderm morphogenesis and endoderm
    formation. Required for efficient differentiation of cells from the primitive streak stage to blood, by acting early
    in the recruitment and/or expansion of mesodermal progenitors to the hemangioblastic and hematopoietic lineages. Also
    involved in the morphogenesis of the heart and the gut during embryogenesis. Acts as a negative regulator of brachyury
    expression (By similarity)

    miRNA
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    Browse MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat MIXL1
    Search QIAGEN for miScript miRNA Assays for microRNAs that regulate MIXL1
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
    Products:            		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for MIXL1 (see all 7)
    OriGene shRNA RFP: MIXL1
    OriGene siRNA: MIXL1
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat MIXL1

    Gene Editing
    Products:    		DNA2.0 Custom Protein Engineering Service for MIXL1

    Clone
    Products:             		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for MIXL1 (see all 3)
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    GenScript: all cDNA clones in your preferred vector: MIXL1 (NM_031944)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for MIXL1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MIXL1 

    Cell Line
    Products:             		GenScript Custom overexpressing Cell Line Services for MIXL1
    Search LifeMap BioReagents cell lines for MIXL1

    In Situ Assay
    Products:       
         		Search Advanced Cell Diagnostics for RNAscope RNA in situ hybridization assays for MIXL1

    Gene Ontology (GO): 5/12 molecular function terms (GO ID links to tree view) (see all 12):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000978RNA polymerase II core promoter proximal region sequence-specific DNA binding ISS--
    GO:0000980RNA polymerase II distal enhancer sequence-specific DNA binding ISS--
    GO:0000987core promoter proximal region sequence-specific DNA binding ISS--
    GO:0001071nucleic acid binding transcription factor activity ISS--
    GO:0001077RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription ISS--


    MIXL1 for ontologies           About GeneDecksing


    2 GenomeRNAi human phenotypes for MIXL1:
     Decreased viability of wild-ty  Increased gamma-H2AX phosphory 

    Animal Models:
         6 MGI mutant phenotypes (inferred from 3 alleles) (MGI details for Mixl1):
     cardiovascular system  craniofacial  digestive/alimentary  embryogenesis  mortality/aging 
     no phenotypic analysis 

    MIXL1 for phenotypes           About GeneDecksing


    Pathways & Interactions
    for MIXL1 gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways  About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1Adipogenesis
    		Adipogenesis1.00


    1 BioSystems Pathway for MIXL1 
        Adipogenesis


    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for MIXL1

    5/8 Interacting proteins for MIXL1 (Q9H2W23) via UniProtKB, MINT, STRING, and/or I2D (see all 8)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ALX4Q9H1613I2D: score=1 
    DLX1P561773I2D: score=1 
    GTF2E1P290833I2D: score=1 
    IRF9Q009783I2D: score=1 
    NEUROD1Q135623I2D: score=1 
    About this table

    Gene Ontology (GO): 5/13 biological process terms (GO ID links to tree view) (see all 13):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001706endoderm formation ----
    GO:0002244hematopoietic progenitor cell differentiation ISS--
    GO:0006351transcription, DNA-dependent ----
    GO:0007369gastrulation ISS--
    GO:0007492endoderm development ISS--


    MIXL1 for ontologies           About GeneDecksing



    Drugs & Compounds
    for MIXL1 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for MIXL1
    Search CenterWatch for drugs/clinical trials and news about MIXL1 

    Transcripts
    for MIXL1 gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for MIXL1 gene: 
    NM_031944.1  

    Unigene Cluster for MIXL1:

    Mix paired-like homeobox
    Hs.282079  [show with all ESTs]
    Unigene Representative Sequence: DR156764
    3 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000542034 ENST00000366810(uc010pvm.2) ENST00000557734

    miRNA
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    Inhib. RNA
    Products:             		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for MIXL1 (see all 7)
    OriGene shRNA RFP: MIXL1
    OriGene siRNA: MIXL1
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat MIXL1
    Clone
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    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for MIXL1
    OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector: MIXL1 (NM_031944)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for MIXL1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MIXL1 
    Primer
    Products:            		 OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for MIXL1
    Browse OriGene validated miRNA SYBR primer pairs
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat MIXL1
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat MIXL1
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat MIXL1

    Additional cDNA sequence: 

    AF211891.1 BC111974.1 BC113441.1 BC143784.1 

    3 DOTS entries:

    DT.40248448  DT.40261413  DT.75140065 

    9 AceView cDNA sequences:

    NM_031944 AF211891 BE552088 AA847809 AI654861 BF513622 BI839065 BG197419 
    AA911377 

    GeneLoc Exon Structure

    2 Alternative Splicing Database (ASD) splice patterns (SP) for MIXL1    About this scheme

    ExUns: 1 ^ 2 ^ 3a · 3b
    SP1:                        
    SP2:                        


    ECgene alternative splicing isoforms for MIXL1

    Expression
    for MIXL1 gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    MIXL1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: GGAGGAACAC

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image

    MIXL1 expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
    5 LifeMap In Vivo Development Anatomical Compartments/Cells 
    Tissue Anatomical Compartment CellCategory (developmental path)
    Gut TubeGut TubePrimitive Gut Endoderm CellsEndoderm
    Primitive StreakPrimitive StreakMesendoderm CellsEarly Embryo
    Primitive StreakPrimitive StreakPrimitive Streak CellsEarly Embryo
    HypoblastVisceral EndodermVisceral Endoderm CellsExtraembryonic Tissues, Yolk Sac
    MesodermMesodermMesoderm CellsEarly Embryo, Mesoderm
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization
    Stem Cell Differentiation: 10/14 LifeMap Cells (see all 14) 
    NameCategory
    Mesoderm-like cells (Direct differentiati...)Mesoderm
    Definitive endoderm-like cells (Generation and expan...)
    Mesendoderm embryoid bodies (Mouse embryonic stem...)
    Activin A-induced embryoid bodies (Mouse embryonic stem...)
    Primitive streak-like cells (Generation of endode...)
    Mesendodermal-like cells (Differentiation of c...)
    Mesendoderm-like cells (Generation of interm...)
    GABA neuron-like cells (Generation of motor ...)Brain
    Chondrocyte-like cells (Direct differentiati...)Bone, Cartilage
    Endoderm-like cells (Generation of hepato...)

    See MIXL1 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for MIXL1

    SOURCE GeneReport for Unigene cluster: Hs.282079

    UniProtKB/Swiss-Prot: MIXL1_HUMAN, Q9H2W2
    Tissue specificity: Restricted to progenitors and secondary lymph tissues. In normal hematopoiesis, it is restricted to
    immature B- and T-lymphoid cells. Present in differentiating embryonic stem cells (at protein level)

        SABiosciences Expression via Pathway-Focused PCR Arrays including MIXL1: 
              Cell Lineage Identification in human mouse rat
              Homeobox (HOX) Genes in human mouse rat

    Primer
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    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat MIXL1
    In Situ
    Assay Products:     
         		Search Advanced Cell Diagnostics for RNAscope RNA in situ hybridization assays for MIXL1

    Orthologs
    for MIXL1 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of animals.

    Orthologs for MIXL1 gene from 3/11 species (see all 11)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    chicken
    (Gallus gallus)    		 Aves F1NL44_CHICK6
    --
    		 --
    		 51(a)
    21(a)
    		 1 ↔ 1
    possible ortholog
    		 3(18207576-18208487)
    Un(10160669-10163999)
    zebrafish
    (Danio rerio)    		 Actinopterygii CR855997.16
    bon6
    		 bonnie and clyde
    		 15(a)
    15(a)
    		 1 ↔ many
    1 ↔ many
    		 20(44305635-44312494)
    20(43746930-43755623)
    worm
    (Caenorhabditis elegans)    		 Secernentea ceh-546
    		 Protein CEH-54
    		 15(a)
    		 1 → many
    		 X(6191555-6192913)


    ENSEMBL Gene Tree for MIXL1 (if available)
    TreeFam Gene Tree for MIXL1 (if available) 

    Paralogs
    for MIXL1 gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for MIXL1 gene
    GSC2  OTX22  HESX12  PROP12  ARGFX2  DMBX12  GSC22  SEBOX2  
    OTX12  CRX2  
    3 SIMAP similar genes for MIXL1 using alignment to 2 protein entries:     MIXL1_HUMAN (see all proteins):
    GSC2    RAX2    NKX2-5

    MIXL1 for paralogs           About GeneDecksing



    Genomic Variants
    for MIXL1 gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/60 NCBI SNPs in MIXL1 are shown (see all 60)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 1 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs1388539701,2
    		--226409402(+) CACCAC/TGCCCG 1 -- us2k10--------
    rs612115901,2
    		--226409407(+) CGCCCG/AGCTAA 1 -- us2k11Minor allele frequency- A:0.50CSA 2
    rs716550121,2
    		C--226409419(+) AATTG-/TTTA  
                TTTAT     		1 -- us2k10--------
    rs115903341,2
    		C,H--226409422(+) TGTTTA/GTTTAT 1 -- us2k10--------
    rs115903361,2
    		H--226409426(+) tatttA/Gtttat 1 -- us2k10--------
    rs12196561,2
    		C,H,--226409604(-) AGCCGG/AGCATG 1 -- us2k15Minor allele frequency- A:0.00NA 10
    rs1834845311,2
    		--226409640(+) GAGACA/GGGGTT 1 -- us2k10--------
    rs12196551,2
    		C,H,--226409751(-) CATCCG/ATTGGC 1 -- us2k111Minor allele frequency- A:0.00NA WA CSA EA 372
    rs1423810001,2
    		--226409762(+) TGGCT-/GGTTTT 1 -- us2k10--------
    rs106933461,2
    		C--226409788(+) TTTTTTT/-CTGAG 1 -- us2k1 trp31Minor allele frequency- -:0.50NA 2

    HapMap Linkage Disequilibrium report for MIXL1 (226411319 - 226414785 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 1 variation for MIXL1
         1 CNV: 48253

    SABiosciences Cancer Mutation PCR Assays
    QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing MIXL1
    DNA2.0 Custom Variant and Variant Library Synthesis for MIXL1

    Disorders / Diseases
    for MIXL1 gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    MIXL1 for disorders           About GeneDecksing

    OMIM gene information: 609852    OMIM disorders: --

    6 diseases for MIXL1:    About MalaCards
    uterine inversion    vascular dementia    hodgkin's lymphoma    dementia
    cholera    hematopoiesis

    3 diseases from the University of Copenhagen DISEASES database for MIXL1:
    Vascular dementia     Cholera     Uterine inversion

    Export disorders for MIXL1 gene to outside databases

    Publications
    for MIXL1 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for MIXL1 gene, integrated from 9 sources (see all 13):
    (articles sorted by number of sources associating them with MIXL1)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. A human Mix-like homeobox gene MIXL shows functional similarity to Xenopus Mix.1. (PubMed id 12070013)1, 2, 3 Guo W....Nagarajan L. (2002)
    2. Differential expression of the human MIXL1 gene product in non- Hodgkin and Hodgkin lymphomas. (PubMed id 17303500)1, 2 Drakos E....Nagarajan L. (2007)
    3. Structure, upstream promoter region, and functional domains of a mouse and human Mix paired-like homeobox gene. (PubMed id 12095687)1, 3 Sahr K....Baron M.H. (2002)
    4. The global gene-expression profiles of U-937 human mac rophages treated with Tat peptide and Tat-FITC conjugate. (PubMed id 22632162)1 Lin C.W....Jan M.S. (2012)
    5. Brachyury and related Tbx proteins interact with the M ixl1 homeodomain protein and negatively regulate Mixl1 transcriptional activity. (PubMed id 22164283)1 Pereira L.A....Elefanty A.G. (2011)
    6. Targeting a GFP reporter gene to the MIXL1 locus of human embryonic stem cells identifies human primitive streak-like cells and enables isolation of primitive hematopoietic precursors. (PubMed id 18032708)1 Davis R.P....Stanley E.G. (2008)
    7. The DNA sequence and biological annotation of human chromosome 1. (PubMed id 16710414)2 Gregory S.G.... Bentley D.R. (2006)
    8. Amino terminal tyrosine phosphorylation of human MIXL1. (PubMed id 17224082)2 Guo W. and Nagarajan L. (2006)
    9. Mixl1 and oct4 proteins are transiently co-expressed in differentiating mouse and human embryonic stem cells. (PubMed id 16433620)2 Mossman A.K.... Elefanty A.G. (2005)
    10. Transcriptional regulation of the homeobox gene Mixl1 by TGF-beta and FoxH1. (PubMed id 15982639)1 Hart A.H....Robb L. (2005)

    External Searches for MIXL1 gene

    (in PubMed, OMIM, and NCBI Bookshelf)
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    Genome Databases showing MIXL1 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 83881 HGNC: 13363 AceView: MIXL1 Ensembl:ENSG00000185155 euGenes: HUgn83881
    ECgene: MIXL1 H-InvDB: MIXL1

    Other Databases showing MIXL1 gene

    (According to HUGE)
    About This Section
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    Specialized Databases showing MIXL1 gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for MIXL1 Pharmacogenomics, SNPs, Pathways

    Intellectual Property
    for MIXL1 gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for MIXL1 gene:
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