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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

MIXL1 Gene

protein-coding   GIFtS: 50
GCID: GC01P226411

Mix Paired-Like Homeobox

(Previous names: Mix1 homeobox (Xenopus laevis)-like 1, Mix1 homeobox-like...)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Mix Paired-Like Homeobox1 2     Mix1 Homeobox (Xenopus Laevis)-Like 11
MIXL2 3 5     Mix1 Homeobox-Like 1 (Xenopus Laevis)1
Homeodomain Protein MIX2 3     MILD12
Mix.1 Homeobox-Like Protein2 3     Homeobox Protein MIXL12
MIX1 Homeobox-Like Protein 12 3     Mix-Like Homeobox Protein 12
MIX2 5     hMix3

External Ids:    HGNC: 133631   Entrez Gene: 838812   Ensembl: ENSG000001851557   OMIM: 6098525   UniProtKB: Q9H2W23   

Export aliases for MIXL1 gene to outside databases

Previous GC identifers: GC01P222227 GC01P222818 GC01P223386 GC01P222718 GC01P224478 GC01P196928


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for MIXL1 Gene:
Homeodomain proteins, such as MIXL1, are transcription factors that regulate cell fate during development (Hart et
al., 2005 (PubMed 15982639)).(supplied by OMIM, Mar 2008)

GeneCards Summary for MIXL1 Gene: 
MIXL1 (Mix paired-like homeobox) is a protein-coding gene. Diseases associated with MIXL1 include uterine inversion, and vascular dementia. GO annotations related to this gene include RNA polymerase II core promoter proximal region sequence-specific DNA binding and protein homodimerization activity. An important paralog of this gene is PROP1.

UniProtKB/Swiss-Prot: MIXL1_HUMAN, Q9H2W2
Function: Transcription factor that play a central role in proper axial mesendoderm morphogenesis and endoderm
formation. Required for efficient differentiation of cells from the primitive streak stage to blood, by acting
early in the recruitment and/or expansion of mesodermal progenitors to the hemangioblastic and hematopoietic
lineages. Also involved in the morphogenesis of the heart and the gut during embryogenesis. Acts as a negative
regulator of brachyury expression (By similarity)




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000001.10  NT_167186.1  NC_018912.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the MIXL1 gene promoter:
         C/EBPbeta   Nkx2-5   POU6F1 (c2)   CUTL1   PPAR-gamma1   POU2F1   POU2F1a   POU2F1b   POU2F1c   PPAR-gamma2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidMIXL1 promoter sequence
   Search SABiosciences Chromatin IP Primers for MIXL1

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat MIXL1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1q42.12   Ensembl cytogenetic band:  1q42.12   HGNC cytogenetic band: 1q42.12

MIXL1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
MIXL1 gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01P226411:  view genomic region     (about GC identifiers)

Start:
226,411,319 bp from pter      End:
226,414,755 bp from pter
Size:
3,437 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: MIXL1_HUMAN, Q9H2W2 (See protein sequence)
Recommended Name: Homeobox protein MIXL1  
Size: 232 amino acids; 24659 Da
Subcellular location: Nucleus

Explore the universe of human proteins at neXtProt for MIXL1: NX_Q9H2W2

Explore proteomics data for MIXL1 at MOPED 

Post-translational modifications:

  • UniProtKB: Phosphorylated at multiple sites
  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q9H2W2

  • MIXL1 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    MIXL1 Protein Expression
    REFSEQ proteins (2 alternative transcripts): 
    NP_001269331.1  NP_114150.1  

    ENSEMBL proteins: 
     ENSP00000442439   ENSP00000355775  

    Human Recombinant Protein Products for MIXL1: 
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    OriGene Protein Over-expression Lysate for MIXL1
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    Novus Biologicals MIXL1 Protein
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for MIXL1 

    Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000790nuclear chromatin ISS--
    GO:0005634nucleus ----

    MIXL1 for ontologies           About GeneDecksing



    MIXL1 Antibody Products: 
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    LSBio Antibodies in human, mouse, rat for MIXL1 

    Assay Products for MIXL1: 
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    Cloud-Clone Corp. ELISAs for MIXL1 
    Cloud-Clone Corp. CLIAs for MIXL1


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    PRD: Homeoboxes / PRD class

    3 InterPro protein domains:
     IPR017970 Homeobox_CS
     IPR001356 Homeodomain
     IPR009057 Homeodomain-like

    Graphical View of Domain Structure for InterPro Entry Q9H2W2

    ProtoNet protein and cluster: Q9H2W2

    UniProtKB/Swiss-Prot: MIXL1_HUMAN, Q9H2W2
    Similarity: Belongs to the paired homeobox family
    Similarity: Contains 1 homeobox DNA-binding domain


    MIXL1 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: MIXL1_HUMAN, Q9H2W2
    Function: Transcription factor that play a central role in proper axial mesendoderm morphogenesis and endoderm
    formation. Required for efficient differentiation of cells from the primitive streak stage to blood, by acting
    early in the recruitment and/or expansion of mesodermal progenitors to the hemangioblastic and hematopoietic
    lineages. Also involved in the morphogenesis of the heart and the gut during embryogenesis. Acts as a negative
    regulator of brachyury expression (By similarity)

         Gene Ontology (GO): 5/13 molecular function terms (GO ID links to tree view) (see all 13):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000978RNA polymerase II core promoter proximal region sequence-specific DNA binding ISS--
    GO:0000980RNA polymerase II distal enhancer sequence-specific DNA binding ISS--
    GO:0000987core promoter proximal region sequence-specific DNA binding ISS--
    GO:0001071nucleic acid binding transcription factor activity ISS--
    GO:0001077RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription ISS--
         
    MIXL1 for ontologies           About GeneDecksing


    Phenotypes:
         2 GenomeRNAi human phenotypes for MIXL1:
     Decreased viability of wild-ty  Increased gamma-H2AX phosphory 

         6 MGI mutant phenotypes (inferred from 3 alleles(MGI details for Mixl1):
     cardiovascular system  craniofacial  digestive/alimentary  embryogenesis  mortality/aging 
     no phenotypic analysis 

    MIXL1 for phenotypes           About GeneDecksing

    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for MIXL1 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for MIXL1

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for MIXL1 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for MIXL1 

    miRNA
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    Inhib. RNA
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MIXL1


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for MIXL1 About                                                                                                See pathways by source

    SuperPathContained pathways About
    1Adipogenesis
    Adipogenesis
    2Cardiac Progenitor Differentiation
    Cardiac Progenitor Differentiation


    2 BioSystems Pathways for MIXL1
        Adipogenesis
    Cardiac Progenitor Differentiation


    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for MIXL1

    5/8 Interacting proteins for MIXL1 (Q9H2W23) via UniProtKB, MINT, STRING, and/or I2D (see all 8)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ALX4Q9H1613I2D: score=1 
    DLX1P561773I2D: score=1 
    GTF2E1P290833I2D: score=1 
    IRF9Q009783I2D: score=1 
    NEUROD1Q135623I2D: score=1 
    About this table

    Gene Ontology (GO): 5/13 biological process terms (GO ID links to tree view) (see all 13):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001706endoderm formation ----
    GO:0002244hematopoietic progenitor cell differentiation ISS--
    GO:0006355regulation of transcription, DNA-dependent ----
    GO:0007369gastrulation ISS--
    GO:0007492endoderm development ISS--

    MIXL1 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for MIXL1

    Search CenterWatch for drugs/clinical trials and news about MIXL1

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for MIXL1 gene (2 alternative transcripts): 
    NM_001282402.1  NM_031944.2  

    Unigene Cluster for MIXL1:

    Mix paired-like homeobox
    Hs.282079  [show with all ESTs]
    Unigene Representative Sequence: DR156764
    3 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000542034 ENST00000366810(uc010pvm.2) ENST00000557734
    miRNA
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    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for MIXL1
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat MIXL1
    Clone
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    OriGene clones in human, mouse for MIXL1 (see all 6)
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    GenScript: all cDNA clones in your preferred vector: MIXL1 (NM_031944)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for MIXL1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MIXL1
    Sirion Biotech Customized lentivirus for stable overexpression of MIXL1 
                         Customized lentivirus expression plasmids for stable overexpression of MIXL1 
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for MIXL1
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    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat MIXL1
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat MIXL1
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat MIXL1

    Additional mRNA sequence: 

    AF211891.1 BC111974.1 BC113441.1 BC143784.1 

    3 DOTS entries:

    DT.40248448  DT.40261413  DT.75140065 

    9 AceView cDNA sequences:

    BE552088 NM_031944 AF211891 AI654861 BF513622 BI839065 AA847809 BG197419 
    AA911377 

    GeneLoc Exon Structure

    2 Alternative Splicing Database (ASD) splice patterns (SP) for MIXL1    About this scheme

    ExUns: 1 ^ 2 ^ 3a · 3b
    SP1:                        
    SP2:                        


    ECgene alternative splicing isoforms for MIXL1

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    MIXL1 expression in normal human tissues (normalized intensities)      MIXL1 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GGAGGAACAC
    MIXL1 Expression
    About this image


    MIXL1 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/13 selected tissues (see all 13) fully expand
     
     Primitive Streak (Early Embryonic Tissues)    fully expand to see all 6 entries
             Mesendoderm Cells Primitive Streak
             Primitive streak-like cells ( Generation of endoderm cells and pancreatic progenitor...
     
     Endoderm (Gastrulation Derivatives)    fully expand to see all 4 entries
             Mesendoderm Cells Primitive Streak
             Endoderm-like cells ( Functional hepatocyte generation from human embryonic stem...
     
     Mesoderm (Gastrulation Derivatives)    fully expand to see all 3 entries
             Mesendoderm Cells Primitive Streak
             Mesoderm-like cells ( Direct differentiation of human embryonic stem cells into chondrocytes...
     
     Gut Tube (Gastrointestinal Tract)    fully expand to see all 2 entries
             Primitive Gut Endoderm Cells Gut Tube
             Definitive endoderm-like cells ( A scalable, suspension protocol for derivation of...
     
     Inner Cell Mass (Early Embryonic Tissues)    fully expand to see all 2 entries
             Line H9 (WA09)

    See MIXL1 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for MIXL1

    SOURCE GeneReport for Unigene cluster: Hs.282079

    UniProtKB/Swiss-Prot: MIXL1_HUMAN, Q9H2W2
    Tissue specificity: Restricted to progenitors and secondary lymph tissues. In normal hematopoiesis, it is
    restricted to immature B- and T-lymphoid cells. Present in differentiating embryonic stem cells (at protein
    level)

        SABiosciences Expression via Pathway-Focused PCR Arrays including MIXL1: 
              Cell Lineage Identification in human mouse rat
              Homeobox (HOX) Genes in human mouse rat

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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MIXL1

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for MIXL1 gene from 5/12 species (see all 12)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Mixl11 , 5 Mix1 homeobox-like 1 (Xenopus laevis)1, 5 74.64(n)1
    70(a)1
      1 (84.46 cM)5
    272171  NM_013729.31  NP_038757.11 
     1806930435 
    lizard
    (Anolis carolinensis)
    Reptilia SEBOX6
    PROP16
    Uncharacterized protein
    25(a)
    20(a)
    1 ↔ 1
    possible ortholog
    GL343470.1(574603-577123)
    GL343252.1(45411-52755)
    zebrafish
    (Danio rerio)
    Actinopterygii bon6
    bon6
    bonnie and clyde
    20(a)
    20(a)
    1 ↔ many
    1 ↔ many
    20(44305635-44312494)
    20(43746930-43755623)
    fruit fly
    (Drosophila melanogaster)
    Insecta CG325326
    --
    7(a)
    possible ortholog
    X(19426045-19441515)
    worm
    (Caenorhabditis elegans)
    Secernentea ceh-536
    unc-426
    Protein UNC-42
    23(a)
    14(a)
    1 ↔ many
    possible ortholog
    IV(3502139-3503912)
    V(9764645-9769361)


    ENSEMBL Gene Tree for MIXL1 (if available)
    TreeFam Gene Tree for MIXL1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for MIXL1 gene
    PROP12  SEBOX2  
    1 SIMAP similar gene for MIXL1 using alignment to 2 protein entries:     MIXL1_HUMAN (see all proteins):
    GSC2

    MIXL1 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/84 SNPs in MIXL1 are shown (see all 84)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 1 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1388539701,2
    --226409402(+) CACCAC/TGCCCG 1 -- us2k10--------
    rs612115901,2
    F--226409407(+) CGCCCG/AGCTAA 1 -- us2k11Minor allele frequency- A:0.50CSA 2
    rs716550121,2
    C--226409419(+) AATTG-/TTTA  
            
    TTTAT
    1 -- us2k10--------
    rs2016698041,2
    C--226409419(+) AATTG-/TTTA  
            
    TTTAT
    1 -- us2k10--------
    rs115903341,2
    C,H--226409422(+) TGTTTA/GTTTAT 1 -- us2k10--------
    rs115903361,2
    H--226409426(+) tatttA/Gtttat 1 -- us2k10--------
    rs558520361,2
    C--226409458(+) TATTT-/ATTT/AT
    TTATTTATTT
    TGAGA
    2 -- us2k1 cds11NA 2
    rs12196561,2
    C,H--226409604(-) AGCCGG/AGCATG 1 -- us2k15Minor allele frequency- A:0.00NA 10
    rs1834845311,2
    --226409640(+) GAGACA/GGGGTT 1 -- us2k10--------
    rs12196551,2
    C,H--226409751(-) CATCCG/ATTGGC 1 -- us2k111Minor allele frequency- A:0.00NA WA CSA EA 372

    HapMap Linkage Disequilibrium report for MIXL1 (226411319 - 226414755 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 3 variations for MIXL1:    About this table     
    Variant IDTypeSubtypePubMed ID
    nsv873233CNV Loss21882294
    nsv832759CNV Loss17160897
    nsv517107CNV Gain+Loss19592680

    SABiosciences Cancer Mutation PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 609852    OMIM disorders: --

    5 diseases for MIXL1:    About MalaCards
    uterine inversion    vascular dementia    dementia    cholera
    hodgkin's lymphoma

    3 diseases from the University of Copenhagen DISEASES database for MIXL1:
    Vascular dementia     Cholera     Uterine inversion

    MIXL1 for disorders           About GeneDecksing


    Export disorders for MIXL1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for MIXL1 gene, integrated from 9 sources (see all 13):
    (articles sorted by number of sources associating them with MIXL1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. A human Mix-like homeobox gene MIXL shows functional similarity to Xenopus Mix.1. (PubMed id 12070013)1, 2, 3 Guo W....Nagarajan L. (2002)
    2. Differential expression of the human MIXL1 gene product in non- Hodgkin and Hodgkin lymphomas. (PubMed id 17303500)1, 2 Drakos E....Nagarajan L. (2007)
    3. Structure, upstream promoter region, and functional domains of a mouse and human Mix paired-like homeobox gene. (PubMed id 12095687)1, 3 Sahr K....Baron M.H. (2002)
    4. The global gene-expression profiles of U-937 human mac rophages treated with Tat peptide and Tat-FITC conjugate. (PubMed id 22632162)1 Lin C.W....Jan M.S. (2012)
    5. Brachyury and related Tbx proteins interact with the M ixl1 homeodomain protein and negatively regulate Mixl1 transcriptional activity. (PubMed id 22164283)1 Pereira L.A....Elefanty A.G. (2011)
    6. Targeting a GFP reporter gene to the MIXL1 locus of human embryonic stem cells identifies human primitive streak-like cells and enables isolation of primitive hematopoietic precursors. (PubMed id 18032708)1 Davis R.P....Stanley E.G. (2008)
    7. The DNA sequence and biological annotation of human chromosome 1. (PubMed id 16710414)2 Gregory S.G.... Bentley D.R. (2006)
    8. Amino terminal tyrosine phosphorylation of human MIXL1. (PubMed id 17224082)2 Guo W. and Nagarajan L. (2006)
    9. Mixl1 and oct4 proteins are transiently co-expressed in differentiating mouse and human embryonic stem cells. (PubMed id 16433620)2 Mossman A.K.... Elefanty A.G. (2005)
    10. Transcriptional regulation of the homeobox gene Mixl1 by TGF-beta and FoxH1. (PubMed id 15982639)1 Hart A.H....Robb L. (2005)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
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      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 83881 HGNC: 13363 AceView: MIXL1 Ensembl:ENSG00000185155 euGenes: HUgn83881
    ECgene: MIXL1 H-InvDB: MIXL1

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for MIXL1 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for MIXL1 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for MIXL1 gene:
    Search GeneIP for patents involving MIXL1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    About This Section

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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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