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Aliases for MITF Gene

Aliases for MITF Gene

  • Melanogenesis Associated Transcription Factor 2 3 5
  • Microphthalmia-Associated Transcription Factor 2 3
  • Class E Basic Helix-Loop-Helix Protein 32 3 4
  • BHLHe32 3 4
  • Microphtalmia-Associated Transcription Factor 3
  • Homolog Of Mouse Microphthalmia 2
  • Waardenburg Syndrome, Type 2A 2
  • CMM8 3
  • WS2A 3
  • WS2 3
  • MI 3

External Ids for MITF Gene

Previous HGNC Symbols for MITF Gene

  • WS2A
  • WS2

Previous GeneCards Identifiers for MITF Gene

  • GC03P068328
  • GC03P069162
  • GC03P069612
  • GC03P069721
  • GC03P069871

Summaries for MITF Gene

Entrez Gene Summary for MITF Gene

  • This gene encodes a transcription factor that contains both basic helix-loop-helix and leucine zipper structural features. It regulates the differentiation and development of melanocytes retinal pigment epithelium and is also responsible for pigment cell-specific transcription of the melanogenesis enzyme genes. Heterozygous mutations in the this gene cause auditory-pigmentary syndromes, such as Waardenburg syndrome type 2 and Tietz syndrome. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008]

GeneCards Summary for MITF Gene

MITF (Melanogenesis Associated Transcription Factor) is a Protein Coding gene. Diseases associated with MITF include Tietz Albinism-Deafness Syndrome and Waardenburg Syndrome, Type 2A. Among its related pathways are Regulation of retinoblastoma protein and Signaling mediated by p38-alpha and p38-beta. GO annotations related to this gene include transcription factor activity, sequence-specific DNA binding and RNA polymerase II core promoter proximal region sequence-specific DNA binding. An important paralog of this gene is TFE3.

UniProtKB/Swiss-Prot for MITF Gene

  • Transcription factor that regulates the expression of genes with essential roles in cell differentiation, proliferation and survival. Binds to symmetrical DNA sequences (E-boxes) (5-CACGTG-3) found in the promoters of target genes, such as BCL2 and tyrosinase (TYR). Plays an important role in melanocyte development by regulating the expression of tyrosinase (TYR) and tyrosinase-related protein 1 (TYRP1). Plays a critical role in the differentiation of various cell types, such as neural crest-derived melanocytes, mast cells, osteoclasts and optic cup-derived retinal pigment epithelium.

Gene Wiki entry for MITF Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MITF Gene

Genomics for MITF Gene

Regulatory Elements for MITF Gene

Enhancers for MITF Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH03F069790 1.2 FANTOM5 Ensembl ENCODE 20.4 +52.3 52306 2.3 PKNOX1 ATF1 ARNT ELK1 GATA2 NCOA1 REST MBD2 MEF2D SMARCA4 MITF RN7SL418P GC03P069838 GC03P069839
GH03F069806 0.2 ENCODE 19.3 +67.7 67683 1.6 HDAC1 CTCF ESRRA ZNF654 JUN REST ZNF384 RAD21 ZNF335 GATA3 MITF GC03P069838 GC03P069839 RN7SL418P
GH03F069784 0.9 Ensembl ENCODE 17.4 +46.8 46778 4.0 PKNOX1 JUN ZMYM3 HIC1 ZNF664 ZNF239 PRDM10 FOS ZSCAN29 ZNF600 MITF RN7SL418P GC03P069838 GC03P069839
GH03F069855 1.3 Ensembl ENCODE 15.8 +116.4 116370 0.8 CTCF HDAC1 ZNF654 ZNF384 REST RAD21 SCRT2 IKZF1 SMC3 KDM1A MITF GC03P069838 GC03P069839 SAMMSON
GH03F069776 1.4 FANTOM5 Ensembl 14 +37.7 37666 1.4 BCOR TAL1 ZMYM3 NCOR1 TRIM24 RNF2 DPF2 TFDP1 ARID1B SMARCA4 MITF RN7SL418P GC03P069838 GC03P069839
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around MITF on UCSC Golden Path with GeneCards custom track

Promoters for MITF Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00001366821 565 3601 ATF1 CREB3L1 ZFP64 ARID4B SIN3A ETS1 YY1 GLIS2 ZNF143 FOS

Genomic Location for MITF Gene

Chromosome:
3
Start:
69,739,435 bp from pter
End:
69,968,337 bp from pter
Size:
228,903 bases
Orientation:
Plus strand

Genomic View for MITF Gene

Genes around MITF on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MITF Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MITF Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MITF Gene

Proteins for MITF Gene

  • Protein details for MITF Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O75030-MITF_HUMAN
    Recommended name:
    Microphthalmia-associated transcription factor
    Protein Accession:
    O75030
    Secondary Accessions:
    • B4DJL2
    • D3K197
    • E9PFN0
    • Q14841
    • Q9P2V0
    • Q9P2V1
    • Q9P2V2
    • Q9P2Y8

    Protein attributes for MITF Gene

    Size:
    526 amino acids
    Molecular mass:
    58795 Da
    Quaternary structure:
    • Efficient DNA binding requires dimerization with another bHLH protein. Binds DNA in the form of homodimer or heterodimer with either TFE3, TFEB or TFEC. Interacts with KARS. Identified in a complex with HINT1 and CTNNB1.

    Three dimensional structures from OCA and Proteopedia for MITF Gene

    Alternative splice isoforms for MITF Gene

neXtProt entry for MITF Gene

Post-translational modifications for MITF Gene

  • Phosphorylation at Ser-405 significantly enhances the ability to bind the tyrosinase promoter. Phosphorylated at Ser-180 and Ser-516 following KIT signaling, trigerring a short live activation: Phosphorylation at Ser-180 and Ser-516 by MAPK and RPS6KA1, respectively, activate the transcription factor activity but also promote ubiquitination and subsequent degradation by the proteasome.
  • Ubiquitinated following phosphorylation at Ser-180, leading to subsequent degradation by the proteasome. Deubiquitinated by USP13, preventing its degradation.
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for MITF Gene

Domains & Families for MITF Gene

Gene Families for MITF Gene

Protein Domains for MITF Gene

Suggested Antigen Peptide Sequences for MITF Gene

Graphical View of Domain Structure for InterPro Entry

O75030

UniProtKB/Swiss-Prot:

MITF_HUMAN :
  • Contains 1 bHLH (basic helix-loop-helix) domain.
  • Belongs to the MiT/TFE family.
Domain:
  • Contains 1 bHLH (basic helix-loop-helix) domain.
Family:
  • Belongs to the MiT/TFE family.
genes like me logo Genes that share domains with MITF: view

Function for MITF Gene

Molecular function for MITF Gene

GENATLAS Biochemistry:
mouse microphthalmia (mi) transcription factor homolog,with an isoform MITF-M,regulator of melanocyte specific expression of the tyrosinase and tyrosinase-related proteins (TYRP1,PEDH) through specific E-box elements,involved in melanogenesis,also involved in osteoclastgenesis,an isoform MITF-A highly expressed in retinal pigment epithelium,a second isoform MITF-H weakly expressed
UniProtKB/Swiss-Prot Function:
Transcription factor that regulates the expression of genes with essential roles in cell differentiation, proliferation and survival. Binds to symmetrical DNA sequences (E-boxes) (5-CACGTG-3) found in the promoters of target genes, such as BCL2 and tyrosinase (TYR). Plays an important role in melanocyte development by regulating the expression of tyrosinase (TYR) and tyrosinase-related protein 1 (TYRP1). Plays a critical role in the differentiation of various cell types, such as neural crest-derived melanocytes, mast cells, osteoclasts and optic cup-derived retinal pigment epithelium.

Gene Ontology (GO) - Molecular Function for MITF Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000978 RNA polymerase II core promoter proximal region sequence-specific DNA binding IDA 14737107
GO:0001077 transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding IMP 14737107
GO:0001227 transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding NAS 24769727
GO:0003677 DNA binding IEA --
GO:0003700 transcription factor activity, sequence-specific DNA binding IEA --
genes like me logo Genes that share ontologies with MITF: view
genes like me logo Genes that share phenotypes with MITF: view

Human Phenotype Ontology for MITF Gene

HPO Id HPO Name Alternative Ids Definition Synonyms

Animal Models for MITF Gene

MGI Knock Outs for MITF:

Animal Model Products

Targeted motifs for MITF Gene
HOMER Transcription Factor Regulatory Elements motif MITF
  • Consensus sequence: RTCATGTGAC Submotif: canonical Cell Type: MastCells GEO ID: GSE48085

Clone Products

  • Addgene plasmids for MITF

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) and Transcription Factor Targets for MITF Gene

Localization for MITF Gene

Subcellular locations from UniProtKB/Swiss-Prot for MITF Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for MITF Gene COMPARTMENTS Subcellular localization image for MITF gene
Compartment Confidence
nucleus 5
cytoskeleton 2
cytosol 1
extracellular 1
lysosome 1
mitochondrion 1
plasma membrane 1
vacuole 1

Gene Ontology (GO) - Cellular Components for MITF Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus NAS 9647758
GO:0005654 nucleoplasm TAS --
GO:0043234 protein complex IDA 20530484
genes like me logo Genes that share ontologies with MITF: view

Pathways & Interactions for MITF Gene

genes like me logo Genes that share pathways with MITF: view

SIGNOR curated interactions for MITF Gene

Is activated by:
Is inactivated by:

Gene Ontology (GO) - Biological Process for MITF Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000122 negative regulation of transcription from RNA polymerase II promoter IMP 24769727
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated NAS 9647758
GO:0006357 regulation of transcription from RNA polymerase II promoter IEA --
GO:0006366 transcription from RNA polymerase II promoter IEA --
genes like me logo Genes that share ontologies with MITF: view

Drugs & Compounds for MITF Gene

(8) Drugs for MITF Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials

(9) Additional Compounds for MITF Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with MITF: view

Transcripts for MITF Gene

Unigene Clusters for MITF Gene

Microphthalmia-associated transcription factor:
Representative Sequences:

Clone Products

  • Addgene plasmids for MITF

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for MITF Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9a · 9b ^ 10a · 10b · 10c ^ 11 ^ 12a · 12b ^ 13 ^ 14a · 14b ^ 15 ^ 16a · 16b ^ 17a · 17b ^ 18 ^ 19 ^
SP1: - - - - - - - - - - - - -
SP2: - -
SP3: - - -
SP4: - - - - - - - - - -
SP5: - - - - -
SP6: -
SP7: -
SP8: - - - -
SP9: - - - - - -
SP10: - - -
SP11:

ExUns: 20
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:
SP11:

Relevant External Links for MITF Gene

GeneLoc Exon Structure for
MITF
ECgene alternative splicing isoforms for
MITF

Expression for MITF Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for MITF Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for MITF Gene

This gene is overexpressed in Muscle - Skeletal (x6.4).

Protein differential expression in normal tissues from HIPED for MITF Gene

This gene is overexpressed in Peripheral blood mononuclear cells (66.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for MITF Gene



Protein tissue co-expression partners for MITF Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of MITF Gene:

MITF

SOURCE GeneReport for Unigene cluster for MITF Gene:

Hs.166017

mRNA Expression by UniProt/SwissProt for MITF Gene:

O75030-MITF_HUMAN
Tissue specificity: Isoform M is exclusively expressed in melanocytes and melanoma cells. Isoform A and isoform H are widely expressed in many cell types including melanocytes and retinal pigment epithelium (RPE). Isoform C is expressed in many cell types including RPE but not in melanocyte-lineage cells. Isoform Mdel is widely expressed in melanocytes, melanoma cell lines and tissues, but almost undetectable in non-melanoma cell lines.
genes like me logo Genes that share expression patterns with MITF: view

Primer Products

Orthologs for MITF Gene

This gene was present in the common ancestor of animals.

Orthologs for MITF Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia MITF 34 35
  • 99.55 (n)
oppossum
(Monodelphis domestica)
Mammalia MITF 35
  • 94 (a)
OneToOne
dog
(Canis familiaris)
Mammalia MITF 34 35
  • 93.55 (n)
cow
(Bos Taurus)
Mammalia MITF 34 35
  • 93.05 (n)
mouse
(Mus musculus)
Mammalia Mitf 34 16 35
  • 89.94 (n)
rat
(Rattus norvegicus)
Mammalia Mitf 34
  • 89.49 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia MITF 35
  • 89 (a)
OneToOne
chicken
(Gallus gallus)
Aves MITF 34 35
  • 83.83 (n)
lizard
(Anolis carolinensis)
Reptilia MITF 35
  • 86 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia mitf 34
  • 77.14 (n)
African clawed frog
(Xenopus laevis)
Amphibia mitfa-A 34
zebrafish
(Danio rerio)
Actinopterygii mitfb 34 35
  • 68.99 (n)
mitfa 35
  • 62 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta Mitf 35
  • 21 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea hlh-30 35
  • 23 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 43 (a)
OneToMany
Species where no ortholog for MITF was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for MITF Gene

ENSEMBL:
Gene Tree for MITF (if available)
TreeFam:
Gene Tree for MITF (if available)

Paralogs for MITF Gene

Paralogs for MITF Gene

(5) SIMAP similar genes for MITF Gene using alignment to 6 proteins:

genes like me logo Genes that share paralogs with MITF: view

Variants for MITF Gene

Sequence variations from dbSNP and Humsavar for MITF Gene

SNP ID Clin Chr 03 pos Sequence Context AA Info Type
rs104893744 Waardenburg syndrome 2A (WS2A) [MIM:193510], Pathogenic 69,959,310(+) AAGCA(C/T)CCGTG reference, missense
rs104893745 Tietz syndrome (TIETZS) [MIM:103500], Pathogenic 69,951,882(+) CACAA(C/G)CTGAG reference, missense
rs104893747 Waardenburg syndrome 2A (WS2A) [MIM:193510], Pathogenic 69,964,880(+) GACTT(C/T)CCCTT reference, missense
rs149617956 Melanoma, cutaneous malignant 8 (CMM8) [MIM:614456], Pathogenic 69,964,940(+) AGCAA(A/G)AACCC reference, missense
VAR_010301 Waardenburg syndrome 2A (WS2A) [MIM:193510]

Structural Variations from Database of Genomic Variants (DGV) for MITF Gene

Variant ID Type Subtype PubMed ID
esv2312935 CNV deletion 18987734
esv2491017 CNV deletion 19546169
esv25567 CNV loss 19812545
esv2567159 CNV deletion 19546169
esv2656588 CNV deletion 23128226
esv2725391 CNV deletion 23290073
esv2725392 CNV deletion 23290073
esv2725393 CNV deletion 23290073
esv2725394 CNV deletion 23290073
esv2725395 CNV deletion 23290073
esv29670 CNV loss 19812545
esv3562043 CNV deletion 23714750
esv3568844 CNV loss 25503493
esv3596505 CNV loss 21293372
esv3596506 CNV loss 21293372
esv5323 CNV loss 18987735
esv7835 CNV loss 19470904
nsv1110410 CNV duplication 24896259
nsv1111245 CNV tandem duplication 24896259
nsv1130797 CNV deletion 24896259
nsv1139123 CNV deletion 24896259
nsv1148008 CNV insertion 26484159
nsv237409 CNV insertion 16902084
nsv477242 CNV novel sequence insertion 20440878
nsv834723 CNV gain 17160897
nsv956292 CNV deletion 24416366

Variation tolerance for MITF Gene

Residual Variation Intolerance Score: 30% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.56; 30.19% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for MITF Gene

Human Gene Mutation Database (HGMD)
MITF
SNPedia medical, phenotypic, and genealogical associations of SNPs for
MITF

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MITF Gene

Disorders for MITF Gene

MalaCards: The human disease database

(52) MalaCards diseases for MITF Gene - From: OMIM, ClinVar, GeneTests, Orphanet, Swiss-Prot, DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
tietz albinism-deafness syndrome
  • tietz syndrome
waardenburg syndrome, type 2a
  • waardenburg syndrome type 2a
melanoma, cutaneous malignant 8
  • melanoma, cutaneous malignant, susceptibility to, 8
waardenburg syndrome/ocular albinism, digenic
  • waardenburg syndrome/albinism, digenic
waardenburg syndrome, type 4a
  • waardenburg's syndrome
- elite association - COSMIC cancer census association via MalaCards
Search MITF in MalaCards View complete list of genes associated with diseases

UniProtKB/Swiss-Prot

MITF_HUMAN
  • Melanoma, cutaneous malignant 8 (CMM8) [MIM:614456]: A malignant neoplasm of melanocytes, arising de novo or from a pre-existing benign nevus, which occurs most often in the skin but also may involve other sites. {ECO:0000269 PubMed:22012259, ECO:0000269 PubMed:22080950}. Note=Disease susceptibility is associated with variations affecting the gene represented in this entry.
  • Tietz syndrome (TIETZS) [MIM:103500]: Autosomal dominant disorder characterized by generalized hypopigmentation and profound, congenital, bilateral deafness. Penetrance is complete. {ECO:0000269 PubMed:10851256}. Note=The disease is caused by mutations affecting the gene represented in this entry.
  • Waardenburg syndrome 2, with ocular albinism, autosomal recessive (WS2-OA) [MIM:103470]: A disorder characterized by the association of features typical of Waardenburg syndrome type 2 with ocular albinism. Patients manifest reduced visual acuity, albinotic fundus, deafness, hypomelanosis. {ECO:0000269 PubMed:9647758}. Note=The disease is caused by mutations affecting the gene represented in this entry.
  • Waardenburg syndrome 2A (WS2A) [MIM:193510]: WS2 is a genetically heterogeneous, autosomal dominant disorder characterized by sensorineural deafness, pigmentary disturbances, and absence of dystopia canthorum. The frequency of deafness is higher in WS2 than in WS1. {ECO:0000269 PubMed:8589691}. Note=The disease is caused by mutations affecting the gene represented in this entry.

Relevant External Links for MITF

Genetic Association Database (GAD)
MITF
Human Genome Epidemiology (HuGE) Navigator
MITF
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
MITF
genes like me logo Genes that share disorders with MITF: view

No data available for Genatlas for MITF Gene

Publications for MITF Gene

  1. Frequent mutations in the MITF pathway in melanoma. (PMID: 19422606) Cronin J.C. … Samuels Y. (Pigment Cell Melanoma Res 2009) 3 22 46 64
  2. Sumoylation of MITF and its related family members TFE3 and TFEB. (PMID: 15507434) Miller A.J. … Fisher D.E. (J. Biol. Chem. 2005) 3 4 22 64
  3. Cloning of MITF, the human homolog of the mouse microphthalmia gene and assignment to chromosome 3p14.1-p12.3. (PMID: 8069297) Tachibana M. … Arnheiter H. (Hum. Mol. Genet. 1994) 2 3 4 64
  4. The tumor suppressor HINT1 regulates MITF and beta-catenin transcriptional activity in melanoma cells. (PMID: 22647378) Genovese G. … Sgambato A. (Cell Cycle 2012) 3 4 64
  5. Simultaneous mutation detection in 90 retinal disease genes in multiple patients using a custom-designed 300-kb retinal resequencing chip. (PMID: 20801516) Booij J.C. … Florijn R.J. (Ophthalmology 2011) 3 46 64

Products for MITF Gene

Sources for MITF Gene

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