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Aliases for MITD1 Gene

Aliases for MITD1 Gene

  • Microtubule Interacting And Trafficking Domain Containing 1 2 3 5
  • MIT, Microtubule Interacting And Transport, Domain Containing 1 2

External Ids for MITD1 Gene

Previous GeneCards Identifiers for MITD1 Gene

  • GC02M099777
  • GC02M093551

Summaries for MITD1 Gene

Entrez Gene Summary for MITD1 Gene

  • Abscission, the separation of daughter cells at the end of cytokinesis, is effected by endosomal sorting complexes required for transport III (ESCRT-III). The protein encoded by this gene functions as a homodimer, with the N-termini binding to a subset of ESCRT-III subunits and the C-termini binding to membranes. The encoded protein regulates ESCRT-III activity and is required for proper cytokinesis. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Feb 2016]

GeneCards Summary for MITD1 Gene

MITD1 (Microtubule Interacting And Trafficking Domain Containing 1) is a Protein Coding gene. GO annotations related to this gene include protein homodimerization activity and phosphatidylinositol binding.

UniProtKB/Swiss-Prot for MITD1 Gene

  • Required for efficient abscission at the end of cytokinesis, together with components of the ESCRT-III complex.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MITD1 Gene

Genomics for MITD1 Gene

Regulatory Elements for MITD1 Gene

Promoters for MITD1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around MITD1 on UCSC Golden Path with GeneCards custom track

Genomic Location for MITD1 Gene

Chromosome:
2
Start:
99,161,427 bp from pter
End:
99,181,061 bp from pter
Size:
19,635 bases
Orientation:
Minus strand

Genomic View for MITD1 Gene

Genes around MITD1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MITD1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MITD1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MITD1 Gene

Proteins for MITD1 Gene

  • Protein details for MITD1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8WV92-MITD1_HUMAN
    Recommended name:
    MIT domain-containing protein 1
    Protein Accession:
    Q8WV92
    Secondary Accessions:
    • Q69YV0

    Protein attributes for MITD1 Gene

    Size:
    249 amino acids
    Molecular mass:
    29314 Da
    Quaternary structure:
    • Homodimer. Interacts (via MIT domain) with CHMP1A, CHMP1B, CHMP2A and IST1.

    Three dimensional structures from OCA and Proteopedia for MITD1 Gene

neXtProt entry for MITD1 Gene

Proteomics data for MITD1 Gene at MOPED

Post-translational modifications for MITD1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for MITD1 Gene

Antibody Products

  • Santa Cruz Biotechnology (SCBT) Antibodies for MITD1

No data available for DME Specific Peptides for MITD1 Gene

Domains & Families for MITD1 Gene

Protein Domains for MITD1 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for MITD1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q8WV92

UniProtKB/Swiss-Prot:

MITD1_HUMAN :
  • The C-terminal domain interacts with lipid membranes containing acidic phosphoinositides and is required for location at the midbody.
Domain:
  • The C-terminal domain interacts with lipid membranes containing acidic phosphoinositides and is required for location at the midbody.
  • The MIT domain interacts with the MIT-interacting motifs of several components of the ESCRT-III complex.
  • Contains 1 MIT domain.
genes like me logo Genes that share domains with MITD1: view

No data available for Gene Families for MITD1 Gene

Function for MITD1 Gene

Molecular function for MITD1 Gene

UniProtKB/Swiss-Prot Function:
Required for efficient abscission at the end of cytokinesis, together with components of the ESCRT-III complex.

Gene Ontology (GO) - Molecular Function for MITD1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0042803 protein homodimerization activity IMP 23015756
genes like me logo Genes that share ontologies with MITD1: view

Phenotypes for MITD1 Gene

genes like me logo Genes that share phenotypes with MITD1: view

Animal Model Products

miRNA for MITD1 Gene

miRTarBase miRNAs that target MITD1

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for MITD1 Gene

Localization for MITD1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for MITD1 Gene

Late endosome membrane; Peripheral membrane protein; Cytoplasmic side. Midbody. Membrane; Peripheral membrane protein; Cytoplasmic side. Note=During cytokinesis, recruited to the midbody via interaction with CHMP1A. Interacts with membranes enriched in phosphoinositides.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for MITD1 Gene COMPARTMENTS Subcellular localization image for MITD1 gene
Compartment Confidence
endosome 5
extracellular 5
cytosol 3
mitochondrion 2
nucleus 1

Gene Ontology (GO) - Cellular Components for MITD1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0031902 late endosome membrane IEA --
GO:0070062 extracellular exosome IDA 19056867
genes like me logo Genes that share ontologies with MITD1: view

Pathways & Interactions for MITD1 Gene

SuperPathways for MITD1 Gene

No Data Available

Gene Ontology (GO) - Biological Process for MITD1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0039702 NOT viral budding via host ESCRT complex IMP 23045692
GO:0071985 NOT multivesicular body sorting pathway IMP 23015756
genes like me logo Genes that share ontologies with MITD1: view

No data available for Pathways by source and SIGNOR curated interactions for MITD1 Gene

Drugs & Compounds for MITD1 Gene

No Compound Related Data Available

Transcripts for MITD1 Gene

Unigene Clusters for MITD1 Gene

MIT, microtubule interacting and transport, domain containing 1:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for MITD1 Gene

ExUns: 1a · 1b · 1c · 1d · 1e · 1f ^ 2a · 2b · 2c ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8a · 8b ^ 9
SP1: - - - -
SP2: - - - - - -
SP3: - - - -
SP4: - - - - -
SP5: - - -
SP6: -
SP7:

Relevant External Links for MITD1 Gene

GeneLoc Exon Structure for
MITD1
ECgene alternative splicing isoforms for
MITD1

Expression for MITD1 Gene

mRNA expression in normal human tissues for MITD1 Gene

Protein differential expression in normal tissues from HIPED for MITD1 Gene

This gene is overexpressed in Urine (41.0) and Breast (20.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for MITD1 Gene



SOURCE GeneReport for Unigene cluster for MITD1 Gene Hs.14222

genes like me logo Genes that share expression patterns with MITD1: view

Protein tissue co-expression partners for MITD1 Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for MITD1 Gene

Orthologs for MITD1 Gene

This gene was present in the common ancestor of animals.

Orthologs for MITD1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia MITD1 36
  • 100 (a)
OneToOne
MITD1 35
  • 99.2 (n)
  • 99.6 (a)
cow
(Bos Taurus)
Mammalia MITD1 36
  • 84 (a)
OneToOne
dog
(Canis familiaris)
Mammalia MITD1 36
  • 84 (a)
OneToOne
MITD1 35
  • 86.7 (n)
  • 82.11 (a)
mouse
(Mus musculus)
Mammalia Mitd1 16
Mitd1 36
  • 85 (a)
OneToOne
Mitd1 35
  • 84.47 (n)
  • 84.74 (a)
oppossum
(Monodelphis domestica)
Mammalia MITD1 36
  • 76 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Mitd1 35
  • 83.67 (n)
  • 85.54 (a)
chicken
(Gallus gallus)
Aves MITD1 35
  • 72.46 (n)
  • 74.58 (a)
MITD1 36
  • 70 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia MITD1 36
  • 71 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia mitd1 35
  • 70.51 (n)
  • 72.65 (a)
zebrafish
(Danio rerio)
Actinopterygii mitd1 36
  • 65 (a)
OneToOne
-- 35
mitd1 35
  • 69.37 (n)
  • 69.19 (a)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP006789 35
  • 48.99 (n)
  • 38.26 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG14985 36
  • 34 (a)
OneToMany
CG30398 36
  • 27 (a)
OneToMany
CG14985 35
  • 46.4 (n)
  • 35.24 (a)
worm
(Caenorhabditis elegans)
Secernentea Y66D12A.10 35
  • 47.15 (n)
  • 36.04 (a)
Y66D12A.10 36
  • 34 (a)
OneToOne
Species with no ortholog for MITD1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for MITD1 Gene

ENSEMBL:
Gene Tree for MITD1 (if available)
TreeFam:
Gene Tree for MITD1 (if available)

Paralogs for MITD1 Gene

(1) SIMAP similar genes for MITD1 Gene using alignment to 4 proteins:

genes like me logo Genes that share paralogs with MITD1: view

No data available for Paralogs for MITD1 Gene

Variants for MITD1 Gene

Sequence variations from dbSNP and Humsavar for MITD1 Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type
rs2087164 -- 99,167,684(+) GCATC(G/T)GGTAC intron-variant, reference, missense
rs2931503 -- 99,164,691(-) CAAAA(A/G)GACCT intron-variant
rs2931505 -- 99,178,492(-) ctact(C/T)gaaca intron-variant
rs2931506 -- 99,178,322(-) CACCA(A/C)TTAAG intron-variant
rs2931521 -- 99,169,010(+) TGTTT(C/T)TTTAA intron-variant, downstream-variant-500B

Variation tolerance for MITD1 Gene

Residual Variation Intolerance Score: 38.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.03; 21.06% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for MITD1 Gene

HapMap Linkage Disequilibrium report
MITD1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for MITD1 Gene

Disorders for MITD1 Gene

Relevant External Links for MITD1

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
MITD1

No disorders were found for MITD1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MITD1 Gene

Publications for MITD1 Gene

  1. A systematic analysis of human CHMP protein interactions: additional MIT domain-containing proteins bind to multiple components of the human ESCRT III complex. (PMID: 16730941) Tsang H.T.H. … Sanderson C.M. (Genomics 2006) 2 3 4 67
  2. Panorama of ancient metazoan macromolecular complexes. (PMID: 26344197) Wan C. … Emili A. (Nature 2015) 3
  3. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T. … Vidal M. (Cell 2014) 3
  4. Proteomic analysis of podocyte exosome-enriched fraction from normal human urine. (PMID: 23376485) Prunotto M. … Moll S. (J Proteomics 2013) 3
  5. In-depth proteomic analyses of exosomes isolated from expressed prostatic secretions in urine. (PMID: 23533145) Principe S. … Drake R.R. (Proteomics 2013) 3

Products for MITD1 Gene

Sources for MITD1 Gene

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