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MITD1 Gene

protein-coding   GIFtS: 47
GCID: GC02M099777

MIT, Microtubule Interacting And Transport, Domain Containing...

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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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This gene clusters with an RNA gene
Subcategory (RNA class): antisense

Quality score for the ORGUL clustered with this gene is 3

Aliases
MIT, Microtubule Interacting And Transport, Domain Containing 11 2
MIT Domain-Containing Protein 12

External Ids:    HGNC: 252071   Entrez Gene: 1295312   Ensembl: ENSG000001584117   UniProtKB: Q8WV923   
ORGUL members:         

Export aliases for MITD1 gene to outside databases

Previous GC identifers: GC02M099152 GC02M093551


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for MITD1 Gene:
MITD1 (MIT, microtubule interacting and transport, domain containing 1) is a protein-coding gene.

UniProtKB/Swiss-Prot: MITD1_HUMAN, Q8WV92
Function: Required for efficient abscission at the end of cytokinesis, together with components of the ESCRT-III
complex




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000002.11  NT_005403.18  NC_018913.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the MITD1 gene promoter:
         USF1   GATA-1   NF-AT   Pax-3   NF-AT4   S8   NF-AT2   USF-1   NF-AT3   NF-AT1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidMITD1 promoter sequence
   Search Chromatin IP Primers for MITD1

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat MITD1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 2q11.2   Ensembl cytogenetic band:  2q11.2   HGNC cytogenetic band: 2q11.2

MITD1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
MITD1 gene location

GeneLoc information about chromosome 2         GeneLoc Exon Structure

GeneLoc location for GC02M099777:  view genomic region     (about GC identifiers)

Start:
99,777,890 bp from pter      End:
99,797,521 bp from pter
Size:
19,632 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: MITD1_HUMAN, Q8WV92 (See protein sequence)
Recommended Name: MIT domain-containing protein 1  
Size: 249 amino acids; 29314 Da
Subunit: Homodimer. Interacts (via MIT domain) with CHMP1A, CHMP1B, CHMP2A and IST1
3 PDB 3D structures from and Proteopedia for MITD1:
2YMB (3D)        4A5X (3D)        4A5Z (3D)    
Secondary accessions: Q69YV0

Explore the universe of human proteins at neXtProt for MITD1: NX_Q8WV92

Explore proteomics data for MITD1 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See MITD1 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_620153.1  
    ENSEMBL proteins: 
     ENSP00000413371   ENSP00000289359   ENSP00000387316   ENSP00000408117  

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    1 InterPro protein domain:
     IPR007330 MIT

    Graphical View of Domain Structure for InterPro Entry Q8WV92

    ProtoNet protein and cluster: Q8WV92

    UniProtKB/Swiss-Prot: MITD1_HUMAN, Q8WV92
    Domain: The C-terminal domain interacts with lipid membranes containing acidic phosphoinositides and is required
    for location at the midbody
    Domain: The MIT domain interacts with the MIT-interacting motifs of several components of the ESCRT-III complex
    Similarity: Contains 1 MIT domain


    Find genes that share domains with MITD1           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: MITD1_HUMAN, Q8WV92
    Function: Required for efficient abscission at the end of cytokinesis, together with components of the ESCRT-III
    complex

         Gene Ontology (GO): 4 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding IPI--
    GO:0019904protein domain specific binding IPI--
    GO:0035091phosphatidylinositol binding IMP--
    GO:0042803protein homodimerization activity IMP--
         
    Find genes that share ontologies with MITD1           About GenesLikeMe


    Phenotypes:
         2 GenomeRNAi human phenotypes for MITD1:
     Increased G2M DNA content  Increased cell number in G2M,  

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for MITD1
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    miRNA
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    miRTarBase miRNAs that target MITD1:
    hsa-mir-100-5p (MIRT048421)

    Block miRNA regulation of human, mouse, rat MITD1 using miScript Target Protectors
    1 qRT-PCR Assays for microRNA that regulate MITD1:
    hsa-miR-485-3p
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    MITD1_HUMAN, Q8WV92: Late endosome membrane; Peripheral membrane protein; Cytoplasmic side. Midbody. Membrane;
    Peripheral membrane protein; Cytoplasmic side. Note=During cytokinesis, recruited to the midbody via interaction
    with CHMP1A. Interacts with membranes enriched in phosphoinositides
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    endosome5
    cytosol3
    mitochondrion2
    nucleus1

    Gene Ontology (GO): 5 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0019898extrinsic component of membrane IDA--
    GO:0030496midbody IMP--
    GO:0031902late endosome membrane IEA--
    GO:0043231intracellular membrane-bounded organelle IDA--
    GO:0070062extracellular vesicular exosome IDA19056867

    Find genes that share ontologies with MITD1           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for MITD1
    Interactions:

        Search GeneGlobe Interaction Network for MITD1

    STRING Interaction Network Preview (showing 2 interactants - click image to see more details)

    5 Interacting proteins for MITD1 (Q8WV921, 3 ENSP000002893594) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    CHMP2AO436333, ENSP000003104404I2D: score=1 STRING: ENSP00000310440
    ALDOAP040753I2D: score=3 
    ATF7P175443I2D: score=1 
    ATP6V1AENSP000002733984STRING: ENSP00000273398
    revP046181EBI-2691489,EBI-6164309
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000281mitotic cytokinesis IMP--
    GO:0000920cytokinetic cell separation IMP--
    GO:0006810transport ----
    GO:0032091negative regulation of protein binding IMP--
    GO:0039702NOT viral budding via host ESCRT complex IMP--

    Find genes that share ontologies with MITD1           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
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    Browse Tocris compounds for MITD1



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for MITD1 gene: 
    NM_138798.1  

    Unigene Cluster for MITD1:

    MIT, microtubule interacting and transport, domain containing 1
    Hs.14222  [show with all ESTs]
    Unigene Representative Sequence: AL161992
    9 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000487588 ENST00000422537 ENST00000464685 ENST00000289359(uc002szs.1)
    ENST00000483721 ENST00000409107 ENST00000466880 ENST00000438121 ENST00000413710

    miRNA
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    1 qRT-PCR Assays for microRNA that regulate MITD1:
    hsa-miR-485-3p
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    Inhib. RNA
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      QuantiFast Probe-based Assays in human, mouse, rat MITD1

    Additional mRNA sequence: 

    AK311658.1 AL161992.1 BC018453.1 

    9 DOTS entries:

    DT.100024776  DT.91823934  DT.95111521  DT.442376  DT.97823753  DT.91762753  DT.95149456  DT.95245908 
    DT.95280605 

    Selected AceView cDNA sequences (see all 120):

    AL161992 BQ575343 CA428284 BU507044 CR608207 BF055289 AA889412 BU623770 
    AI392952 AI423553 AA830731 AI631790 BG779414 AA731697 AI168274 BU625600 
    AI492483 AI022063 AW338448 AA805113 BI914077 AI913306 BF940122 BX460728 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for MITD1 (see all 7)    About this scheme

    ExUns: 1a · 1b · 1c · 1d · 1e · 1f ^ 2a · 2b · 2c ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8a · 8b ^ 9
    SP1:                                -           -     -     -                                             
    SP2:                                -           -     -     -                             -     -         
    SP3:                                -           -     -     -                                             
    SP4:                                -           -     -     -           -                                 
    SP5:                                -           -     -                                                   


    ECgene alternative splicing isoforms for MITD1

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    MITD1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: AAACAACAGT
    MITD1 Expression
    About this image

    MITD1 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    MITD1 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.14222
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    Assay Products:
     

     
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for MITD1 gene from Selected species (see all 13)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Mitd11 , 5 MIT, microtubule interacting and transport, domain more1, 5 84.47(n)1
    84.74(a)1
      1 (16.13 cM)5
    690281  NM_026913.21  NP_081189.11 
     378748015 
    chicken
    (Gallus gallus)
    Aves MITD11 MIT, microtubule interacting and transport, domain more 72.46(n)
    74.58(a)
      418698  XM_416894.3  XP_416894.2 
    lizard
    (Anolis carolinensis)
    Reptilia MITD16
    MIT, microtubule interacting and transport, domain...
    71(a)
    1 ↔ 1
    GL343940.1(86357-94655)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia CF377219.12   -- 78.42(n)    CF377219.1 
    zebrafish
    (Danio rerio)
    Actinopterygii BC045955.12   -- 74.42(n)   393170  BC045955.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG149851 CG14985 46.4(n)
    35.24(a)
      38470  NM_139589.2  NP_647846.2 
    worm
    (Caenorhabditis elegans)
    Secernentea Y66D12A.101 Y66D12A.10 47.15(n)
    36.04(a)
      176587  NM_067091.5  NP_499492.1 


    ENSEMBL Gene Tree for MITD1 (if available)
    TreeFam Gene Tree for MITD1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for MITD1 gene
    1 SIMAP similar gene for MITD1 using alignment to 4 protein entries:     MITD1_HUMAN (see all proteins):
    VPS4B

    Find genes that share paralogs with MITD1           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for MITD1 (see all 184)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 2 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1867319051,2
    --99785327(+) AGCCTC/TAACCT 1 -- int10--------
    rs729591411,2
    C,F--99785441(+) TTTTTG/TCTGAT 1 -- int13Minor allele frequency- T:0.33NA WA CSA 6
    rs1899582581,2
    --99785564(+) ATAGAC/TGCTTA 1 -- int10--------
    rs1409463401,2
    C--99785589(+) GCTCCC/TGCAGC 1 -- int10--------
    rs1498386101,2
    C--99785801(+) ATTCAC/GTTAAA 1 -- ut310--------
    rs1822208411,2
    C--99785818(+) ATAATA/GCAAAT 1 -- ut310--------
    rs1458719891,2
    C--99785853(+) TTTGTA/GTGCTT 2 H syn10--------
    rs2003126241,2
    --99785971(+) TGATAA/CAAAAA 1 -- int10--------
    rs1417443861,2
    C--99786098(+) GTATTA/GTATTC 1 -- int11Minor allele frequency- G:0.00EU 1307
    rs1996578831,2
    C--99786121(+) TCAGAA/CTATTA 1 -- int10--------

    HapMap Linkage Disequilibrium report for MITD1 (99777890 - 99797521 bp)

    Structural Variations
          Database of Genomic Variants (DGV) variations for MITD1: --
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing MITD1
    DNA2.0 Custom Variant and Variant Library Synthesis for MITD1

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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      --

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for MITD1 gene, integrated from 10 sources (see all 16):
    (articles sorted by number of sources associating them with MITD1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. A systematic analysis of human CHMP protein interactions: additional MIT domain-containing proteins bind to multiple components of the human ESCRT III complex. (PubMed id 16730941)1, 2, 3 Tsang H.T.H....Sanderson C.M. (Genomics 2006)
    2. MITD1 is recruited to midbodies by ESCRT-III and participates in cytokinesis. (PubMed id 23015756)1, 2 Lee S.... Blackstone C. (Mol. Biol. Cell 2012)
    3. ESCRT-III binding protein MITD1 is involved in cytokinesis and has an unanticipated PLD fold that binds membranes. (PubMed id 23045692)1, 2 Hadders M.A.... Martin-Serrano J. (Proc. Natl. Acad. Sci. U.S.A. 2012)
    4. Generation and annotation of the DNA sequences of human chromosomes 2 and 4. (PubMed id 15815621)1, 2 Hillier L.W.... Wilson R.K. (Nature 2005)
    5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    6. Global landscape of HIV-human protein complexes. (PubMed id 22190034)1 JAoger S....Krogan N.J. (Nature 2012)
    7. Large-scale genome-wide association analysis of bipolar disorder identifies a new susceptibility locus near ODZ4. (PubMed id 21926972)1 (Nat. Genet. 2011)
    8. Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (BMC Syst. Biol. 2011)
    9. ErbB2-associated changes in the lysosomal proteome. (PubMed id 21674799)1 Nylandsted J....JAoAottelAo M. (Proteomics 2011)
    10. A comprehensive resource of interacting protein regions for refining human transcription factor networks. (PubMed id 20195357)1 Miyamoto-Sato E....Yanagawa H. (PLoS ONE 2010)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 129531 HGNC: 25207 AceView: LOC129531 Ensembl:ENSG00000158411 euGenes: HUgn129531
    ECgene: MITD1 H-InvDB: MITD1

    (According to HUGE)
    About This Section

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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for MITD1 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

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    Patent Information for MITD1 gene:
    Search GeneIP for patents involving MITD1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
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