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Aliases for MITD1 Gene

Aliases for MITD1 Gene

  • MIT, Microtubule Interacting And Transport, Domain Containing 1 2 3

External Ids for MITD1 Gene

Previous GeneCards Identifiers for MITD1 Gene

  • GC02M099777
  • GC02M093551

Summaries for MITD1 Gene

GeneCards Summary for MITD1 Gene

MITD1 (MIT, Microtubule Interacting And Transport, Domain Containing 1) is a Protein Coding gene.

UniProtKB/Swiss-Prot for MITD1 Gene

  • Required for efficient abscission at the end of cytokinesis, together with components of the ESCRT-III complex.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MITD1 Gene

Genomics for MITD1 Gene

Regulatory Elements for MITD1 Gene

Genomic Location for MITD1 Gene

Start:
99,161,427 bp from pter
End:
99,181,058 bp from pter
Size:
19,632 bases
Orientation:
Minus strand

Genomic View for MITD1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for MITD1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MITD1 Gene

Proteins for MITD1 Gene

  • Protein details for MITD1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8WV92-MITD1_HUMAN
    Recommended name:
    MIT domain-containing protein 1
    Protein Accession:
    Q8WV92
    Secondary Accessions:
    • Q69YV0

    Protein attributes for MITD1 Gene

    Size:
    249 amino acids
    Molecular mass:
    29314 Da
    Quaternary structure:
    • Homodimer. Interacts (via MIT domain) with CHMP1A, CHMP1B, CHMP2A and IST1.

    Three dimensional structures from OCA and Proteopedia for MITD1 Gene

neXtProt entry for MITD1 Gene

Proteomics data for MITD1 Gene at MOPED

Post-translational modifications for MITD1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for MITD1 Gene

No data available for DME Specific Peptides for MITD1 Gene

Domains for MITD1 Gene

Protein Domains for MITD1 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for MITD1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q8WV92

UniProtKB/Swiss-Prot:

MITD1_HUMAN :
  • Q8WV92
Domain:
  • The C-terminal domain interacts with lipid membranes containing acidic phosphoinositides and is required for location at the midbody.
  • The MIT domain interacts with the MIT-interacting motifs of several components of the ESCRT-III complex.
  • Contains 1 MIT domain.
genes like me logo Genes that share domains with MITD1: view

No data available for Gene Families for MITD1 Gene

Function for MITD1 Gene

Molecular function for MITD1 Gene

UniProtKB/Swiss-Prot Function: Required for efficient abscission at the end of cytokinesis, together with components of the ESCRT-III complex.

Gene Ontology (GO) - Molecular Function for MITD1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 22190034
GO:0019904 protein domain specific binding IPI 23015756
GO:0035091 phosphatidylinositol binding IMP 23045692
GO:0042803 protein homodimerization activity IMP 23015756
genes like me logo Genes that share ontologies with MITD1: view

Phenotypes for MITD1 Gene

GenomeRNAi human phenotypes for MITD1:
genes like me logo Genes that share phenotypes with MITD1: view

miRNA for MITD1 Gene

miRTarBase miRNAs that target MITD1

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for MITD1 Gene

Localization for MITD1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for MITD1 Gene

Late endosome membrane; Peripheral membrane protein; Cytoplasmic side. Midbody. Membrane; Peripheral membrane protein; Cytoplasmic side. Note=During cytokinesis, recruited to the midbody via interaction with CHMP1A. Interacts with membranes enriched in phosphoinositides.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for MITD1 Gene COMPARTMENTS Subcellular localization image for MITD1 gene
Compartment Confidence
endosome 5
cytosol 3
mitochondrion 2
nucleus 1

Gene Ontology (GO) - Cellular Components for MITD1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005768 endosome --
GO:0019898 extrinsic component of membrane IDA 23045692
GO:0030496 midbody IMP 23015756
GO:0031902 late endosome membrane IEA --
GO:0043231 intracellular membrane-bounded organelle IDA --
genes like me logo Genes that share ontologies with MITD1: view

Pathways for MITD1 Gene

SuperPathways for MITD1 Gene

No Data Available

Gene Ontology (GO) - Biological Process for MITD1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000281 mitotic cytokinesis IMP 23045692
GO:0000920 cell separation after cytokinesis IMP 23015756
GO:0032091 negative regulation of protein binding IMP 23015756
GO:0039702 NOT viral budding via host ESCRT complex IMP 23045692
GO:0071985 NOT multivesicular body sorting pathway IMP 23015756
genes like me logo Genes that share ontologies with MITD1: view

No data available for Pathways by source for MITD1 Gene

Transcripts for MITD1 Gene

Unigene Clusters for MITD1 Gene

MIT, microtubule interacting and transport, domain containing 1:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for MITD1 Gene

ExUns: 1a · 1b · 1c · 1d · 1e · 1f ^ 2a · 2b · 2c ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8a · 8b ^ 9
SP1: - - - -
SP2: - - - - - -
SP3: - - - -
SP4: - - - - -
SP5: - - -
SP6: -
SP7:

Relevant External Links for MITD1 Gene

GeneLoc Exon Structure for
MITD1
ECgene alternative splicing isoforms for
MITD1

Expression for MITD1 Gene

mRNA expression in normal human tissues for MITD1 Gene

Integrated Proteomics: protein expression from ProteomicsDB, MOPED, and MaxQB for MITD1 Gene

SOURCE GeneReport for Unigene cluster for MITD1 Gene Hs.14222

genes like me logo Genes that share expressions with MITD1: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for MITD1 Gene

Orthologs for MITD1 Gene

This gene was present in the common ancestor of animals.

Orthologs for MITD1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia MITD1 35
  • 99.2 (n)
  • 99.6 (a)
MITD1 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia MITD1 36
  • 84 (a)
OneToOne
dog
(Canis familiaris)
Mammalia MITD1 35
  • 86.7 (n)
  • 82.11 (a)
MITD1 36
  • 84 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Mitd1 35
  • 84.47 (n)
  • 84.74 (a)
Mitd1 16
Mitd1 36
  • 85 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia MITD1 36
  • 76 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Mitd1 35
  • 83.67 (n)
  • 85.54 (a)
chicken
(Gallus gallus)
Aves MITD1 35
  • 72.46 (n)
  • 74.58 (a)
MITD1 36
  • 70 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia MITD1 36
  • 71 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia mitd1 35
  • 70.51 (n)
  • 72.65 (a)
zebrafish
(Danio rerio)
Actinopterygii -- 35
mitd1 35
  • 69.37 (n)
  • 69.19 (a)
mitd1 36
  • 65 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP006789 35
  • 48.99 (n)
  • 38.26 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG14985 35
  • 46.4 (n)
  • 35.24 (a)
CG14985 36
  • 34 (a)
OneToMany
CG30398 36
  • 27 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea Y66D12A.10 35
  • 47.15 (n)
  • 36.04 (a)
Y66D12A.10 36
  • 34 (a)
OneToOne
Species with no ortholog for MITD1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for MITD1 Gene

ENSEMBL:
Gene Tree for MITD1 (if available)
TreeFam:
Gene Tree for MITD1 (if available)

Paralogs for MITD1 Gene

Selected SIMAP similar genes for MITD1 Gene using alignment to 4 proteins:

genes like me logo Genes that share paralogs with MITD1: view

No data available for Paralogs for MITD1 Gene

Variants for MITD1 Gene

Sequence variations from dbSNP and Humsavar for MITD1 Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type MAF
rs2171359 -- 99,178,897(-) CATGT(A/G)TCTGA intron-variant
rs2931505 -- 99,178,492(-) ctact(C/T)gaaca intron-variant
rs2931506 -- 99,178,322(-) CACCA(A/C)TTAAG intron-variant
rs2931521 -- 99,169,010(+) TGTTT(C/T)TTTAA downstream-variant-500B
rs2969389 -- 99,169,004(+) TCCAT(C/T)TGTCT downstream-variant-500B

Relevant External Links for MITD1 Gene

HapMap Linkage Disequilibrium report
MITD1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for MITD1 Gene

Disorders for MITD1 Gene

No disorders were found for MITD1 Gene.

No data available for UniProtKB/Swiss-Prot for MITD1 Gene

Publications for MITD1 Gene

  1. A systematic analysis of human CHMP protein interactions: additional MIT domain-containing proteins bind to multiple components of the human ESCRT III complex. (PMID: 16730941) Tsang H.T.H. … Sanderson C.M. (Genomics 2006) 2 3 4
  2. MITD1 is recruited to midbodies by ESCRT-III and participates in cytokinesis. (PMID: 23015756) Lee S. … Blackstone C. (Mol. Biol. Cell 2012) 3 4
  3. ESCRT-III binding protein MITD1 is involved in cytokinesis and has an unanticipated PLD fold that binds membranes. (PMID: 23045692) Hadders M.A. … Martin-Serrano J. (Proc. Natl. Acad. Sci. U.S.A. 2012) 3 4
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  5. Generation and annotation of the DNA sequences of human chromosomes 2 and 4. (PMID: 15815621) Hillier L.W. … Wilson R.K. (Nature 2005) 3 4

Products for MITD1 Gene

Sources for MITD1 Gene

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