MITD1 Gene
protein-coding GIFtS: 43
GCID: GC02M099777
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MIT, microtubule interacting and transport, domain containing...
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Aliases
for MITD1 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| MIT, Microtubule Interacting And Transport, Domain Containing 11 2 | | LOC1295311 | | MIT Domain-Containing Protein 12 |
Export aliases for MITD1 gene to outside databasesPrevious GC identifers: GC02M099152 GC02M093551 |
Summaries
for MITD1 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
UniProtKB/Swiss-Prot: MITD1_HUMAN, Q8WV92Function: Required for efficient abscission at the end of cytokinesis, together with components of the ESCRT-IIIcomplex
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Genomic Views
for MITD1 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000002.11 NC_018913.1 NT_022171.15
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the MITD1 gene promoter:
USF1 GATA-1 NF-AT Pax-3 NF-AT4 S8 NF-AT2 USF-1 NF-AT3 NF-AT1
Other transcription factors
Search SABiosciences Chromatin IP Primers for MITD1
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat MITD1 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 2q11.2 Ensembl cytogenetic band: 2q11.2 HGNC cytogenetic band: 2q11.2MITD1 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 2 GeneLoc Exon Structure GeneLoc location for GC02M099777: view genomic region
(about GC identifiers)
Start:
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99,777,890 bp from pter |
End:
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99,797,521 bp from pter |
Size:
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19,632 bases |
Orientation:
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minus strand |
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Proteins
for MITD1 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: MITD1_HUMAN, Q8WV92 (See
protein sequence)Recommended Name: MIT domain-containing protein 1 Size: 249 amino acids; 29314 Da
Subunit: Homodimer. Interacts (via MIT domain) with CHMP1A, CHMP1B, CHMP2A and IST1
Subcellular location: Late endosome membrane; Peripheral membrane protein; Cytoplasmic side. Midbody. Membrane;Peripheral membrane protein; Cytoplasmic side. Note=During cytokinesis, recruited to the midbody via interaction withCHMP1A. Interacts with membranes enriched in phosphoinositides
3 PDB 3D structures from  and Proteopedia  for MITD1:2YMB (3D)
4A5X (3D)
4A5Z (3D)
Secondary accessions: Q69YV0Explore the universe of human proteins at neXtProt for MITD1: NX_Q8WV92
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q8WV92
MITD1 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_620153.1
ENSEMBL proteins: ENSP00000413371 ENSP00000289359 ENSP00000387316 ENSP00000408117 ENSP00000390142
Human Recombinant Protein Products:
Gene Ontology (GO): 4 cellular component terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0019898 | extrinsic to membrane |
IDA | -- | | GO:0030496 | colocalizes with midbody |
IDA | -- | | GO:0031902 | late endosome membrane |
IEA | -- | | GO:0043231 | intracellular membrane-bounded organelle |
IDA | -- |
MITD1 for ontologies About GeneDecksing
MITD1 Antibody Products:
Assay Products for MITD1: |
Protein
Domains /
Families
for MITD1 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
MITD1 for domains About GeneDecksing
1 InterPro domain/family:Graphical View of Domain Structure for InterPro Entry Q8WV92ProtoNet protein and cluster: Q8WV92 UniProtKB/Swiss-Prot: MITD1_HUMAN, Q8WV92Domain: The C-terminal domain interacts with lipid membranes containing acidic phosphoinositides and is required forlocation at the midbodySimilarity: Contains 1 MIT domain |
Function
for MITD1 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: MITD1_HUMAN, Q8WV92Function: Required for efficient abscission at the end of cytokinesis, together with components of the ESCRT-IIIcomplex
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for MITD1 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for MITD1
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
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| |  | GenScript: all cDNA clones in your preferred vector: MITD1 (NM_138798) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for MITD1 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MITD1 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MITD1 |
Gene Ontology (GO): 1 molecular function term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0005515 | protein binding |
IPI | -- |
MITD1 for ontologies About GeneDecksing
2 GenomeRNAi human phenotypes for MITD1:
|
Pathways & Interactions
for MITD1 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for MITD1
STRING Interaction
Network Preview (showing 2 interactants - click image to see more details)
5 Interacting proteins for MITD1 (Q8WV921, 3 ENSP000002893594) via UniProtKB, MINT, STRING, and/or I2DAbout this table
Gene Ontology (GO): 4 biological process terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0000281 | cytokinesis after mitosis |
IMP | -- | | GO:0006810 | transport |
IEA | -- | | GO:0015031 | protein transport |
-- | -- | | GO:2000695 | cytokinetic cell separation involved in cell cycle cytokinesis |
IMP | -- |
MITD1 for ontologies About GeneDecksing
|
Drugs & Compounds
for MITD1 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for MITD1
Search CenterWatch for drugs/clinical trials and news about MITD1
|
Transcripts
for MITD1 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for MITD1 gene: NM_138798.1 Unigene Cluster for MITD1: MIT, microtubule interacting and transport, domain containing 1 Hs.14222 [show with all ESTs]Unigene Representative Sequence: AL1619929 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000487588 ENST00000422537 ENST00000464685 ENST00000289359(uc002szs.1)
ENST00000483721 ENST00000409107 ENST00000466880 ENST00000438121 ENST00000413710
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for MITD1 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for MITD1
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: MITD1 (NM_138798) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for MITD1 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MITD1 |
Additional cDNA sequence: AK311658.1 AL161992.1 BC018453.1 9 DOTS entries: DT.100024776 DT.91823934 DT.95111521 DT.442376 DT.97823753 DT.91762753 DT.95149456 DT.95245908 DT.95280605 24/120 AceView cDNA sequences (see all 120): AI363337 AA043723 AW086444 BF196669 AA805113 BI914077 AL161992 BU625600 BC018453 AA758009 BG779414 BQ447932 AA731697 NM_138798 CB851329 AI423553 CR608207 AA283607 AI392952 AI766809 BU631074 BX460728 BF940122 AI492483
GeneLoc Exon Structure
5/7 Alternative Splicing Database (ASD) splice patterns (SP) for MITD1 (see all 7) About this scheme
| ExUns: | 1a | · | 1b | · | 1c | · | 1d | · | 1e | · | 1f | ^ | 2a | · | 2b | · | 2c | ^ | 3 | ^ | 4 | ^ | 5 | ^ | 6 | ^ | 7 | ^ | 8a | · | 8b | ^ | 9 |
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| SP1: | | | | | | | | | | | - | | | | - | | - | | - | | | | | | | | | | | | | | | | |
| SP2: | | | | | | | | | | | - | | | | - | | - | | - | | | | | | | | | | - | | - | | | | |
| SP3: | | | | | | | | | | | - | | | | - | | - | | - | | | | | | | | | | | | | | | | |
| SP4: | | | | | | | | | | | - | | | | - | | - | | - | | | | - | | | | | | | | | | | | |
| SP5: | | | | | | | | | | | - | | | | - | | - | | | | | | | | | | | | | | | | | |
ECgene alternative splicing isoforms for MITD1
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Expression
for MITD1 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| MITD1 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: AAACAACAGT
About this image
See MITD1 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for MITD1
SOURCE GeneReport for Unigene cluster: Hs.14222
SABiosciences Custom PCR Arrays for MITD1
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for MITD1
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat MITD1 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat MITD1 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat MITD1 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MITD1 |
Orthologs
for MITD1 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of animals.
Orthologs for MITD1 gene from 7/19 species (see all 19) About this table
ENSEMBL Gene Tree for MITD1 (if available)
TreeFam Gene Tree for MITD1 (if available) |
Paralogs
for MITD1 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| -- |
Genomic Variants
for MITD1 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 2 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for MITD1 (99777890 - 99797521 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for MITD1: -- | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing MITD1 |
|
Disorders
/ Diseases
for MITD1 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
| -- |
Publications
for MITD1 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for MITD1 gene, integrated from 9 sources (see all 14):
(articles sorted by number of sources associating them with MITD1) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- A systematic analysis of human CHMP protein interactions: additional MIT domain-containing proteins bind to multiple components of the human ESCRT III complex. (PubMed id 16730941)1, 2, 3 Tsang H.T.H....Sanderson C.M. (2006)
- ESCRT-III binding protein MITD1 is involved in cytokinesis and has an unanticipated PLD fold that binds membranes. (PubMed id 23045692)1, 2 Hadders M.A.... Martin-Serrano J. (2012)
- Generation and annotation of the DNA sequences of human chromosomes 2 and 4. (PubMed id 15815621)1, 2 Hillier L.W....Wilson R.K. (2005)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- Global landscape of HIV-human protein complexes. (PubMed id 22190034)1 Jager S....Krogan N.J. (2012)
- MITD1 is recruited to midbodies by ESCRT-III and participates in cytokinesis. (PubMed id 23015756)2 Lee S.... Blackstone C. (2012)
- Large-scale genome-wide association analysis of bipol ar disorder identifies a new susceptibility locus near ODZ4. (PubMed id 21926972)1 Sklar P....Purcell S.M. (2011)
- Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (2011)
- ErbB2-associated changes in the lysosomal proteome. (PubMed id 21674799)1 Nylandsted J....Jaattela M. (2011)
- Essential role of hIST1 in cytokinesis. (PubMed id 19129480)2 Agromayor M.... Martin-Serrano J. (2009)
|
External Searches for MITD1 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing MITD1 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing MITD1 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing MITD1 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for MITD1 | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for MITD1 gene:
Search GeneIP for patents involving MITD1
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for MITD1 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for MITD1 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for MITD1 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for MITD1 | | | OriGene Protein Over-expression Lysate for MITD1 | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for MITD1 | | Browse 3'-UTR reporter clones for miRNA target validation | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for MITD1 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for MITD1 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | OriGene Purified Protein for MITD1 | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for MITD1 | | OriGene Custom Protein Services for MITD1 | | | OriGene Custom Immunoassay Development | | |
| |
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat MITD1 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing MITD1 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat MITD1 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat MITD1 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat MITD1 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat MITD1 |
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 | | | MITD1 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MITD1 |
|  |  |  | | | | Search ThermoFisher Antibodies for MITD1 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MITD1 |
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