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Aliases for MITD1 Gene

Aliases for MITD1 Gene

  • Microtubule Interacting And Trafficking Domain Containing 1 2 3 5
  • MIT, Microtubule Interacting And Transport, Domain Containing 1 2

External Ids for MITD1 Gene

Previous GeneCards Identifiers for MITD1 Gene

  • GC02M099777
  • GC02M093551

Summaries for MITD1 Gene

Entrez Gene Summary for MITD1 Gene

  • Abscission, the separation of daughter cells at the end of cytokinesis, is effected by endosomal sorting complexes required for transport III (ESCRT-III). The protein encoded by this gene functions as a homodimer, with the N-termini binding to a subset of ESCRT-III subunits and the C-termini binding to membranes. The encoded protein regulates ESCRT-III activity and is required for proper cytokinesis. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Feb 2016]

GeneCards Summary for MITD1 Gene

MITD1 (Microtubule Interacting And Trafficking Domain Containing 1) is a Protein Coding gene. GO annotations related to this gene include protein homodimerization activity and phosphatidylinositol binding.

UniProtKB/Swiss-Prot for MITD1 Gene

  • Required for efficient abscission at the end of cytokinesis, together with components of the ESCRT-III complex.

No data available for CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MITD1 Gene

Genomics for MITD1 Gene

Regulatory Elements for MITD1 Gene

Enhancers for MITD1 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH02G098767 1.7 FANTOM5 Ensembl ENCODE dbSUPER 13 +410.4 410387 6.1 FOXA2 NFIB ZSCAN4 ARID4B DMAP1 ZSCAN9 RARA GATA2 FOS ZNF548 MGAT4A ENSG00000273306 REV1 MITD1 LOC550644 UNC50 TSGA10 LYG1 INPP4A C2orf15
GH02G098725 1.6 FANTOM5 ENCODE dbSUPER 11.1 +451.6 451639 7.4 PKNOX1 ARID4B SIN3A FEZF1 DMAP1 ZNF48 YY1 GLIS2 GATA2 ZNF143 MITD1 RNU4-84P LOC550644 RNU7-46P LYG1 MGAT4A INPP4A YWHAQP5
GH02G099179 1.2 ENCODE 14.7 -0.5 -476 3.4 MLX CREB3L1 DMAP1 YY1 SLC30A9 ZNF143 ZNF263 SP3 NFYC TBX21 TSGA10 MITD1 LIPT1 UNC50 ENSG00000241962 LYG1 MRPL30 LYG2
GH02G098798 1.3 Ensembl ENCODE dbSUPER 13 +380.8 380825 2.6 ELF3 SOX13 FOXA2 JUN RARA TEAD3 SLC30A9 NCOR1 ZNF548 FOS ENSG00000273306 REV1 MITD1 LOC550644 RNU7-46P MGAT4A UNC50 TSGA10 RNU4-84P GC02M098841
GH02G099487 1.4 FANTOM5 ENCODE 10.4 -308.4 -308446 3.4 PKNOX1 MLX ZFP64 ARID4B SIN3A DMAP1 ZNF2 ZBTB7B YY1 SLC30A9 REV1 ENSG00000273306 TSGA10 LYG1 LOC550644 MITD1 UNC50
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around MITD1 on UCSC Golden Path with GeneCards custom track

Promoters for MITD1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000120539 -139 2401 MLX CREB3L1 DMAP1 YY1 SLC30A9 ZNF143 ZNF263 SP3 NFYC TBX21

Genomic Location for MITD1 Gene

Chromosome:
2
Start:
99,161,427 bp from pter
End:
99,181,061 bp from pter
Size:
19,635 bases
Orientation:
Minus strand

Genomic View for MITD1 Gene

Genes around MITD1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MITD1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MITD1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MITD1 Gene

Proteins for MITD1 Gene

  • Protein details for MITD1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8WV92-MITD1_HUMAN
    Recommended name:
    MIT domain-containing protein 1
    Protein Accession:
    Q8WV92
    Secondary Accessions:
    • Q69YV0

    Protein attributes for MITD1 Gene

    Size:
    249 amino acids
    Molecular mass:
    29314 Da
    Quaternary structure:
    • Homodimer. Interacts (via MIT domain) with CHMP1A, CHMP1B, CHMP2A and IST1.

    Three dimensional structures from OCA and Proteopedia for MITD1 Gene

neXtProt entry for MITD1 Gene

Post-translational modifications for MITD1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for MITD1 Gene

Domains & Families for MITD1 Gene

Protein Domains for MITD1 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for MITD1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q8WV92

UniProtKB/Swiss-Prot:

MITD1_HUMAN :
  • The C-terminal domain interacts with lipid membranes containing acidic phosphoinositides and is required for location at the midbody.
Domain:
  • The C-terminal domain interacts with lipid membranes containing acidic phosphoinositides and is required for location at the midbody.
  • The MIT domain interacts with the MIT-interacting motifs of several components of the ESCRT-III complex.
genes like me logo Genes that share domains with MITD1: view

No data available for Gene Families for MITD1 Gene

Function for MITD1 Gene

Molecular function for MITD1 Gene

UniProtKB/Swiss-Prot Function:
Required for efficient abscission at the end of cytokinesis, together with components of the ESCRT-III complex.

Gene Ontology (GO) - Molecular Function for MITD1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 16730941
GO:0019904 protein domain specific binding IPI 23015756
GO:0035091 phosphatidylinositol binding IMP 23045692
GO:0042803 protein homodimerization activity IMP 23015756
genes like me logo Genes that share ontologies with MITD1: view

Phenotypes for MITD1 Gene

genes like me logo Genes that share phenotypes with MITD1: view

Animal Model Products

CRISPR Products

miRNA for MITD1 Gene

miRTarBase miRNAs that target MITD1

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for MITD1 Gene

Localization for MITD1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for MITD1 Gene

Late endosome membrane; Peripheral membrane protein; Cytoplasmic side. Midbody. Membrane; Peripheral membrane protein; Cytoplasmic side. Note=During cytokinesis, recruited to the midbody via interaction with CHMP1A. Interacts with membranes enriched in phosphoinositides.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for MITD1 gene
Compartment Confidence
extracellular 5
endosome 5
cytosol 3
mitochondrion 2
nucleus 1

Gene Ontology (GO) - Cellular Components for MITD1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005768 endosome IEA --
GO:0016020 membrane IEA --
GO:0019898 extrinsic component of membrane IDA 23045692
GO:0030496 midbody IMP 23015756
GO:0031902 late endosome membrane IEA --
genes like me logo Genes that share ontologies with MITD1: view

Pathways & Interactions for MITD1 Gene

SuperPathways for MITD1 Gene

No Data Available

Gene Ontology (GO) - Biological Process for MITD1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000281 mitotic cytokinesis IMP 23045692
GO:0000920 cell separation after cytokinesis IMP 23015756
GO:0006810 transport IEA --
GO:0007049 cell cycle IEA --
GO:0032091 negative regulation of protein binding IMP 23015756
genes like me logo Genes that share ontologies with MITD1: view

No data available for Pathways by source and SIGNOR curated interactions for MITD1 Gene

Transcripts for MITD1 Gene

Unigene Clusters for MITD1 Gene

MIT, microtubule interacting and transport, domain containing 1:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for MITD1 Gene

ExUns: 1a · 1b · 1c · 1d · 1e · 1f ^ 2a · 2b · 2c ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8a · 8b ^ 9
SP1: - - - -
SP2: - - - - - -
SP3: - - - -
SP4: - - - - -
SP5: - - -
SP6: -
SP7:

Relevant External Links for MITD1 Gene

GeneLoc Exon Structure for
MITD1
ECgene alternative splicing isoforms for
MITD1

Expression for MITD1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for MITD1 Gene

Protein differential expression in normal tissues from HIPED for MITD1 Gene

This gene is overexpressed in Urine (41.0) and Breast (20.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for MITD1 Gene



Protein tissue co-expression partners for MITD1 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of MITD1 Gene:

MITD1

SOURCE GeneReport for Unigene cluster for MITD1 Gene:

Hs.14222

Evidence on tissue expression from TISSUES for MITD1 Gene

  • Nervous system(4.4)
  • Spleen(2)
genes like me logo Genes that share expression patterns with MITD1: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for MITD1 Gene

Orthologs for MITD1 Gene

This gene was present in the common ancestor of animals.

Orthologs for MITD1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia MITD1 34 35
  • 99.2 (n)
dog
(Canis familiaris)
Mammalia MITD1 34 35
  • 86.7 (n)
mouse
(Mus musculus)
Mammalia Mitd1 34 16 35
  • 84.47 (n)
cow
(Bos Taurus)
Mammalia MITD1 35
  • 84 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Mitd1 34
  • 83.67 (n)
oppossum
(Monodelphis domestica)
Mammalia MITD1 35
  • 76 (a)
OneToOne
chicken
(Gallus gallus)
Aves MITD1 34 35
  • 72.46 (n)
lizard
(Anolis carolinensis)
Reptilia MITD1 35
  • 71 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia mitd1 34
  • 70.51 (n)
zebrafish
(Danio rerio)
Actinopterygii mitd1 34 35
  • 69.37 (n)
-- 34
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP006789 34
  • 48.99 (n)
fruit fly
(Drosophila melanogaster)
Insecta CG14985 34 35
  • 46.4 (n)
CG30398 35
  • 27 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea Y66D12A.10 34 35
  • 47.15 (n)
Species where no ortholog for MITD1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for MITD1 Gene

ENSEMBL:
Gene Tree for MITD1 (if available)
TreeFam:
Gene Tree for MITD1 (if available)

Paralogs for MITD1 Gene

(1) SIMAP similar genes for MITD1 Gene using alignment to 4 proteins:

genes like me logo Genes that share paralogs with MITD1: view

No data available for Paralogs for MITD1 Gene

Variants for MITD1 Gene

Sequence variations from dbSNP and Humsavar for MITD1 Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type
rs137891647 Pathogenic 99,162,832(+) ACAGT(C/G)ACACT intron-variant, nc-transcript-variant, reference, stop-gained
rs137973334 Pathogenic 99,162,249(+) TGGCT(C/G/T)GGAGA intron-variant, nc-transcript-variant, reference, missense
rs767568897 Pathogenic 99,162,169(+) TCCCT(C/G/T)TGTTG intron-variant, nc-transcript-variant, reference, missense
rs786205156 Pathogenic 99,162,492(+) ATTGC(A/G)CTTTA intron-variant, nc-transcript-variant, reference, missense
rs863224892 Pathogenic 99,162,763(+) AACTT(A/G)GGAGT intron-variant, nc-transcript-variant, reference, stop-gained

Structural Variations from Database of Genomic Variants (DGV) for MITD1 Gene

Variant ID Type Subtype PubMed ID
esv3591732 CNV gain 21293372

Variation tolerance for MITD1 Gene

Residual Variation Intolerance Score: 38.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.03; 21.06% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for MITD1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MITD1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MITD1 Gene

Disorders for MITD1 Gene

Relevant External Links for MITD1

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
MITD1

No disorders were found for MITD1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MITD1 Gene

Publications for MITD1 Gene

  1. A systematic analysis of human CHMP protein interactions: additional MIT domain-containing proteins bind to multiple components of the human ESCRT III complex. (PMID: 16730941) Tsang H.T.H. … Sanderson C.M. (Genomics 2006) 2 3 4 64
  2. ESCRT-III binding protein MITD1 is involved in cytokinesis and has an unanticipated PLD fold that binds membranes. (PMID: 23045692) Hadders M.A. … Martin-Serrano J. (Proc. Natl. Acad. Sci. U.S.A. 2012) 3 4 64
  3. MITD1 is recruited to midbodies by ESCRT-III and participates in cytokinesis. (PMID: 23015756) Lee S. … Blackstone C. (Mol. Biol. Cell 2012) 3 4 64
  4. Generation and annotation of the DNA sequences of human chromosomes 2 and 4. (PMID: 15815621) Hillier L.W. … Wilson R.K. (Nature 2005) 3 4 64
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64

Products for MITD1 Gene

Sources for MITD1 Gene

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