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Aliases for MISP Gene

Aliases for MISP Gene

  • Mitotic Spindle Positioning 2 3 5
  • Mitotic Interactor And Substrate Of Plk1 2 3
  • Mitotic Spindle Positioning Protein 3 4
  • C19orf21 3 4
  • Chromosome 19 Open Reading Frame 21 2
  • Caprice 3

External Ids for MISP Gene

Previous HGNC Symbols for MISP Gene

  • C19orf21

Summaries for MISP Gene

Entrez Gene Summary for MISP Gene

  • The protein encoded by this gene is an actin-bundling protein involved in determining cell morphology and mitotic progression. The encoded protein is required for the proper positioning of the mitotic spindle. Two transcript variants, one protein-coding and the other non-protein coding, have been found for this gene. [provided by RefSeq, Feb 2016]

GeneCards Summary for MISP Gene

MISP (Mitotic Spindle Positioning) is a Protein Coding gene. GO annotations related to this gene include actin binding.

UniProtKB/Swiss-Prot for MISP Gene

  • Plays a role in mitotic spindle orientation and mitotic progression. Regulates the distribution of dynactin at the cell cortex in a PLK1-dependent manner, thus stabilizing cortical and astral microtubule attachments required for proper mitotic spindle positioning. May link microtubules to the actin cytospkeleton and focal adhesions. May be required for directed cell migration and centrosome orientation. May also be necessary for proper stacking of the Golgi apparatus.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MISP Gene

Genomics for MISP Gene

Genomic Location for MISP Gene

Chromosome:
19
Start:
748,421 bp from pter
End:
764,318 bp from pter
Size:
15,898 bases
Orientation:
Plus strand

Genomic View for MISP Gene

Genes around MISP on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MISP Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MISP Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MISP Gene

No data available for Regulatory Elements for MISP Gene

Proteins for MISP Gene

  • Protein details for MISP Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8IVT2-MISP_HUMAN
    Recommended name:
    Mitotic interactor and substrate of PLK1
    Protein Accession:
    Q8IVT2

    Protein attributes for MISP Gene

    Size:
    679 amino acids
    Molecular mass:
    75357 Da
    Quaternary structure:
    • Associates with F-actin. Interacts with DCTN1; this interaction regulates DCTN1 distribution at the cell cortex. Interacts with PTK2/FAK and MAPRE1.

neXtProt entry for MISP Gene

Proteomics data for MISP Gene at MOPED

Post-translational modifications for MISP Gene

  • Phosphorylated by CDK1 and PLK1. CDK1 is the priming kinase for PLK1 phosphorylation. Phosphorylation by PLK1 is required for proper spindle orientation at metaphase.
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for MISP Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for MISP Gene

Domains & Families for MISP Gene

Protein Domains for MISP Gene

InterPro:
ProtoNet:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with MISP: view

No data available for Gene Families , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for MISP Gene

Function for MISP Gene

Molecular function for MISP Gene

UniProtKB/Swiss-Prot Function:
Plays a role in mitotic spindle orientation and mitotic progression. Regulates the distribution of dynactin at the cell cortex in a PLK1-dependent manner, thus stabilizing cortical and astral microtubule attachments required for proper mitotic spindle positioning. May link microtubules to the actin cytospkeleton and focal adhesions. May be required for directed cell migration and centrosome orientation. May also be necessary for proper stacking of the Golgi apparatus.
genes like me logo Genes that share phenotypes with MISP: view

Animal Model Products

miRNA for MISP Gene

miRTarBase miRNAs that target MISP

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for MISP Gene

Localization for MISP Gene

Subcellular locations from UniProtKB/Swiss-Prot for MISP Gene

Cell junction, focal adhesion. Cytoplasm, cytoskeleton. Cytoplasm, cell cortex. Note=Predominantly localizes to cortical actin structures during interphase and mitosis. Present in retraction fibers, which are formed at former adhesion sites during mitosis, and at spicular membrane protrusions in re-attaching cytokinetic cells. Partially colocalizes with cytoplasmic F-actin. Not detected at microtubules at interphase, nor at spindle during mitosis.

Gene Ontology (GO) - Cellular Components for MISP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005925 focal adhesion IDA --
genes like me logo Genes that share ontologies with MISP: view

No data available for Subcellular locations from COMPARTMENTS for MISP Gene

Pathways & Interactions for MISP Gene

SuperPathways for MISP Gene

No Data Available

Interacting Proteins for MISP Gene

STRING Interaction Network Preview (showing 1 interactants - click image to see details)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000215582%0d%0a9606.ENSP00000344818%0d%0a
Selected Interacting proteins: ENSP00000215582 for MISP Gene via STRING

Symbol External ID(s) Details
UBC

Gene Ontology (GO) - Biological Process for MISP Gene

None

No data available for Pathways by source and SIGNOR curated interactions for MISP Gene

Drugs & Compounds for MISP Gene

No Compound Related Data Available

Transcripts for MISP Gene

Alternative Splicing Database (ASD) splice patterns (SP) for MISP Gene

No ASD Table

Relevant External Links for MISP Gene

GeneLoc Exon Structure for
MISP
ECgene alternative splicing isoforms for
MISP

Expression for MISP Gene

mRNA expression in normal human tissues for MISP Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for MISP Gene

This gene is overexpressed in Colon - Transverse (x23.7) and Small Intestine - Terminal Ileum (x17.3).

Protein differential expression in normal tissues from HIPED for MISP Gene

This gene is overexpressed in Nasal epithelium (54.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MOPED, and MaxQB for MISP Gene



genes like me logo Genes that share expression patterns with MISP: view

Primer Products

In Situ Assay Products

No data available for mRNA Expression by UniProt/SwissProt and Protein tissue co-expression partners for MISP Gene

Orthologs for MISP Gene

This gene was present in the common ancestor of chordates.

Orthologs for MISP Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia MISP 36
  • 98 (a)
OneToOne
MISP 35
  • 98.77 (n)
  • 98.23 (a)
cow
(Bos Taurus)
Mammalia MISP 35
  • 75.62 (n)
  • 67.08 (a)
MISP 36
  • 62 (a)
OneToOne
dog
(Canis familiaris)
Mammalia MISP 36
  • 55 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Misp 16
Misp 36
  • 65 (a)
OneToOne
Misp 35
  • 72.59 (n)
  • 66.67 (a)
oppossum
(Monodelphis domestica)
Mammalia MISP 36
  • 32 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia MISP 36
  • 35 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Misp 35
  • 72.41 (n)
  • 66.61 (a)
chicken
(Gallus gallus)
Aves C28H19ORF21 35
  • 54.87 (n)
  • 43.71 (a)
MISP 36
  • 31 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia MISP 36
  • 33 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia misp 35
  • 41.67 (n)
  • 32.06 (a)
Species with no ortholog for MISP:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for MISP Gene

ENSEMBL:
Gene Tree for MISP (if available)
TreeFam:
Gene Tree for MISP (if available)

Paralogs for MISP Gene

No data available for Paralogs for MISP Gene

Variants for MISP Gene

Sequence variations from dbSNP and Humsavar for MISP Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type
rs3746173 - 757,412(+) AGAGC(A/C/G)GCACC reference, missense
rs3746175 - 757,641(+) CCCCA(A/G)GGCCT reference, missense
rs8107847 - 763,508(+) CCTGG(A/G)AGCCA reference, missense
rs35384259 - 757,752(-) GGACA(C/T)TGGCC reference, missense
rs45477999 - 757,241(+) TGGGC(A/G)CCAGG reference, missense

Variation tolerance for MISP Gene

Residual Variation Intolerance Score: 97% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 5.25; 70.15% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for MISP Gene

HapMap Linkage Disequilibrium report
MISP

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for MISP Gene

Disorders for MISP Gene

Relevant External Links for MISP

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
MISP

No disorders were found for MISP Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MISP Gene

Publications for MISP Gene

  1. MISP is a novel Plk1 substrate required for proper spindle orientation and mitotic progression. (PMID: 23509069) Zhu M. … Hoffmann I. (J. Cell Biol. 2013) 2 3 4 67
  2. Caprice/MISP is a novel F-actin bundling protein critical for actin-based cytoskeletal reorganizations. (PMID: 24475924) Kumeta M. … Takeyasu K. (Genes Cells 2014) 2 3
  3. The novel actin/focal adhesion-associated protein MISP is involved in mitotic spindle positioning in human cells. (PMID: 23574715) Maier B. … Kraemer A. (Cell Cycle 2013) 2 3
  4. Systematic analysis of human protein complexes identifies chromosome segregation proteins. (PMID: 20360068) Hutchins J.R. … Peters J.M. (Science 2010) 3
  5. Proteomic and targeted analytical identification of BXDC1 and EBNA1BP2 as dynamic scaffold proteins in the nucleolus. (PMID: 19170763) Hirano Y. … Horigome T. (Genes Cells 2009) 3

Products for MISP Gene

Sources for MISP Gene

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