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Aliases for MISP Gene

Aliases for MISP Gene

  • Mitotic Spindle Positioning 2 3 5
  • Mitotic Spindle Positioning Protein 3 4
  • C19orf21 3 4
  • Mitotic Interactor And Substrate Of Plk1 2
  • Mitotic Interactor And Substrate Of PLK1 3
  • Chromosome 19 Open Reading Frame 21 2
  • Caprice 3
  • MISP1 3

External Ids for MISP Gene

Previous HGNC Symbols for MISP Gene

  • C19orf21

Summaries for MISP Gene

Entrez Gene Summary for MISP Gene

  • The protein encoded by this gene is an actin-bundling protein involved in determining cell morphology and mitotic progression. The encoded protein is required for the proper positioning of the mitotic spindle. Two transcript variants, one protein-coding and the other non-protein coding, have been found for this gene. [provided by RefSeq, Feb 2016]

GeneCards Summary for MISP Gene

MISP (Mitotic Spindle Positioning) is a Protein Coding gene. GO annotations related to this gene include actin binding.

UniProtKB/Swiss-Prot for MISP Gene

  • Plays a role in mitotic spindle orientation and mitotic progression. Regulates the distribution of dynactin at the cell cortex in a PLK1-dependent manner, thus stabilizing cortical and astral microtubule attachments required for proper mitotic spindle positioning. May link microtubules to the actin cytospkeleton and focal adhesions. May be required for directed cell migration and centrosome orientation. May also be necessary for proper stacking of the Golgi apparatus.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MISP Gene

Genomics for MISP Gene

Regulatory Elements for MISP Gene

Enhancers for MISP Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH19F000747 1.4 FANTOM5 ENCODE 22.7 +3.5 3495 9.4 ATF1 PKNOX1 ARID4B SIN3A BRCA1 ZNF143 FOS SP5 NFYC MIER2 MISP PRTN3 ELANE CFD CIRBP ENSG00000268798 FSTL3 PLPP2 TPGS1 GC19P000749
GH19F000737 0.4 ENCODE 8.9 -7.8 -7760 7.1 MLX ZFP64 ARID4B DMAP1 ZNF48 SLC30A9 ZNF143 SP5 NFYC MXD4 MISP GC19M000724
GH19F000744 0.5 ENCODE 7.5 -3.2 -3208 1.4 TFAP4 ESRRA SAP130 MLX ETV1 RARA NR2F6 GATAD2A TFE3 USF2 MISP GC19M000724
GH19F000727 0.8 Ensembl ENCODE 6 -20.4 -20380 1.6 ESRRA BCL11B RARA CTBP1 TRIM24 NR2F6 NR2F1 CEBPB ZBTB7A NR2F2 MISP GC19M000724 PALM
GH19F000288 1.2 FANTOM5 Ensembl ENCODE 1.8 -458.3 -458319 2.9 TBP SREBF2 SIN3A RCOR1 FOS ZNF263 SMARCC1 CEBPB USF2 SMARCB1 PLPP2 WASH5P GZMM MISP RNF126 C2CD4C LILRA3
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around MISP on UCSC Golden Path with GeneCards custom track

Genomic Location for MISP Gene

Chromosome:
19
Start:
748,421 bp from pter
End:
764,318 bp from pter
Size:
15,898 bases
Orientation:
Plus strand

Genomic View for MISP Gene

Genes around MISP on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MISP Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MISP Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MISP Gene

Proteins for MISP Gene

  • Protein details for MISP Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8IVT2-MISP_HUMAN
    Recommended name:
    Mitotic interactor and substrate of PLK1
    Protein Accession:
    Q8IVT2

    Protein attributes for MISP Gene

    Size:
    679 amino acids
    Molecular mass:
    75357 Da
    Quaternary structure:
    • Associates with F-actin. Interacts with DCTN1; this interaction regulates DCTN1 distribution at the cell cortex. Interacts with PTK2/FAK and MAPRE1.

neXtProt entry for MISP Gene

Post-translational modifications for MISP Gene

  • Phosphorylated by CDK1 and PLK1. CDK1 is the priming kinase for PLK1 phosphorylation. Phosphorylation by PLK1 is required for proper spindle orientation at metaphase.
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for MISP Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for MISP Gene

Domains & Families for MISP Gene

Protein Domains for MISP Gene

InterPro:
ProtoNet:

Graphical View of Domain Structure for InterPro Entry

Q8IVT2

UniProtKB/Swiss-Prot:

MISP_HUMAN :
  • Belongs to the MISP family.
Family:
  • Belongs to the MISP family.
genes like me logo Genes that share domains with MISP: view

No data available for Gene Families and Suggested Antigen Peptide Sequences for MISP Gene

Function for MISP Gene

Molecular function for MISP Gene

UniProtKB/Swiss-Prot Function:
Plays a role in mitotic spindle orientation and mitotic progression. Regulates the distribution of dynactin at the cell cortex in a PLK1-dependent manner, thus stabilizing cortical and astral microtubule attachments required for proper mitotic spindle positioning. May link microtubules to the actin cytospkeleton and focal adhesions. May be required for directed cell migration and centrosome orientation. May also be necessary for proper stacking of the Golgi apparatus.

Gene Ontology (GO) - Molecular Function for MISP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003779 actin binding IEA --
genes like me logo Genes that share ontologies with MISP: view
genes like me logo Genes that share phenotypes with MISP: view

Animal Model Products

miRNA for MISP Gene

miRTarBase miRNAs that target MISP

Inhibitory RNA Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for MISP Gene

Localization for MISP Gene

Subcellular locations from UniProtKB/Swiss-Prot for MISP Gene

Cell junction, focal adhesion. Cytoplasm, cytoskeleton. Cytoplasm, cell cortex. Note=Predominantly localizes to cortical actin structures during interphase and mitosis. Present in retraction fibers, which are formed at former adhesion sites during mitosis, and at spicular membrane protrusions in re-attaching cytokinetic cells. Partially colocalizes with cytoplasmic F-actin. Not detected at microtubules at interphase, nor at spindle during mitosis.

Gene Ontology (GO) - Cellular Components for MISP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IEA --
GO:0005856 cytoskeleton IEA --
GO:0005886 plasma membrane IDA --
GO:0005925 focal adhesion IDA --
GO:0005938 cell cortex IEA --
genes like me logo Genes that share ontologies with MISP: view

No data available for Subcellular locations from COMPARTMENTS for MISP Gene

Pathways & Interactions for MISP Gene

SuperPathways for MISP Gene

No Data Available

Interacting Proteins for MISP Gene

STRING Interaction Network Preview (showing 1 interactants - click image to see details)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000215582%0d%0a9606.ENSP00000344818%0d%0a
Selected Interacting proteins: ENSP00000215582 Q8IVT2-MISP_HUMAN for MISP Gene via STRING IID

Gene Ontology (GO) - Biological Process for MISP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007049 cell cycle IEA --
GO:0007067 mitotic nuclear division IEA --
GO:0051301 cell division IEA --
genes like me logo Genes that share ontologies with MISP: view

No data available for Pathways by source and SIGNOR curated interactions for MISP Gene

Transcripts for MISP Gene

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for MISP Gene

No ASD Table

Relevant External Links for MISP Gene

GeneLoc Exon Structure for
MISP
ECgene alternative splicing isoforms for
MISP

Expression for MISP Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for MISP Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for MISP Gene

This gene is overexpressed in Colon - Transverse (x23.7) and Small Intestine - Terminal Ileum (x17.3).

Protein differential expression in normal tissues from HIPED for MISP Gene

This gene is overexpressed in Nasal epithelium (54.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for MISP Gene



NURSA nuclear receptor signaling pathways regulating expression of MISP Gene:

MISP
genes like me logo Genes that share expression patterns with MISP: view

Primer Products

No data available for Protein tissue co-expression partners and mRNA Expression by UniProt/SwissProt for MISP Gene

Orthologs for MISP Gene

This gene was present in the common ancestor of chordates.

Orthologs for MISP Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia MISP 34 35
  • 98.77 (n)
cow
(Bos Taurus)
Mammalia MISP 34 35
  • 75.62 (n)
mouse
(Mus musculus)
Mammalia Misp 34 16 35
  • 72.59 (n)
rat
(Rattus norvegicus)
Mammalia Misp 34
  • 72.41 (n)
dog
(Canis familiaris)
Mammalia MISP 35
  • 55 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia MISP 35
  • 35 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia MISP 35
  • 32 (a)
OneToOne
chicken
(Gallus gallus)
Aves C28H19ORF21 34
  • 54.87 (n)
MISP 35
  • 31 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia MISP 35
  • 33 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia misp 34
  • 41.67 (n)
Species where no ortholog for MISP was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for MISP Gene

ENSEMBL:
Gene Tree for MISP (if available)
TreeFam:
Gene Tree for MISP (if available)

Paralogs for MISP Gene

No data available for Paralogs for MISP Gene

Variants for MISP Gene

Sequence variations from dbSNP and Humsavar for MISP Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type
rs10406007 -- 746,965(+) CTGGA(A/G)AGAGG upstream-variant-2KB, utr-variant-3-prime
rs10409372 -- 756,723(+) TCACA(A/G)AGGTT intron-variant
rs10410087 -- 763,018(+) GGCAC(A/G)GTGGC intron-variant
rs10416525 -- 759,629(+) tctcc(C/T)gacct intron-variant
rs10421265 -- 746,712(+) GAGGC(C/T)GCCTC upstream-variant-2KB, reference, synonymous-codon

Structural Variations from Database of Genomic Variants (DGV) for MISP Gene

Variant ID Type Subtype PubMed ID
dgv134n111 CNV deletion 26073780
esv3643364 CNV gain 21293372
esv3643369 CNV loss 21293372
esv3893155 CNV gain 25118596
nsv458320 CNV loss 19166990
nsv470101 CNV loss 18288195
nsv520063 CNV loss 19592680
nsv577978 CNV gain 21841781
nsv578165 CNV loss 21841781
nsv578166 CNV loss 21841781
nsv953938 CNV deletion 24416366

Variation tolerance for MISP Gene

Residual Variation Intolerance Score: 97% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 5.25; 70.15% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for MISP Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MISP

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MISP Gene

Disorders for MISP Gene

Relevant External Links for MISP

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
MISP

No disorders were found for MISP Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MISP Gene

Publications for MISP Gene

  1. MISP is a novel Plk1 substrate required for proper spindle orientation and mitotic progression. (PMID: 23509069) Zhu M. … Hoffmann I. (J. Cell Biol. 2013) 2 3 4 64
  2. The novel actin/focal adhesion-associated protein MISP is involved in mitotic spindle positioning in human cells. (PMID: 23574715) Maier B. … Kraemer A. (Cell Cycle 2013) 2 3 4 64
  3. Caprice/MISP is a novel F-actin bundling protein critical for actin-based cytoskeletal reorganizations. (PMID: 24475924) Kumeta M. … Takeyasu K. (Genes Cells 2014) 2 3 64
  4. Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PMID: 17081983) Olsen J.V. … Mann M. (Cell 2006) 3 4 64
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64

Products for MISP Gene

Sources for MISP Gene

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