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MISP Gene

protein-coding   GIFtS: 34
GCID: GC19P000752

Mitotic Spindle Positioning

(Previous name: chromosome 19 open reading frame 21)
(Previous symbol: C19orf21)
  Search for MISP
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Mitotic Spindle Positioning1 2
C19orf211 2 3 5
Mitotic Interactor And Substrate Of Plk11 2
Mitotic Spindle Positioning Protein2 3
Chromosome 19 Open Reading Frame 211
caprice2

External Ids:    HGNC: 270001   Entrez Gene: 1263532   Ensembl: ENSG000000998127   OMIM: 6152895   UniProtKB: Q8IVT23   

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(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for MISP Gene:
MISP (mitotic spindle positioning) is a protein-coding gene. GO annotations related to this gene include actin binding.

UniProtKB/Swiss-Prot: MISP_HUMAN, Q8IVT2
Function: Plays a role in mitotic spindle orientation and mitotic progression. Regulates the distribution of
dynactin at the cell cortex in a PLK1-dependent manner, thus stabilizing cortical and astral microtubule
attachments required for proper mitotic spindle positioning. May link microtubules to the actin cytospkeleton and
focal adhesions. May be required for directed cell migration and centrosome orientation. May also be necessary
for proper stacking of the Golgi apparatus




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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Regulatory elements:
   Search for regulatory transcription factor binding sites for MISP
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search Chromatin IP Primers for MISP

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat MISP


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 19p13.3   Ensembl cytogenetic band:  19p13.3   HGNC cytogenetic band: 19p13.3

MISP Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
MISP gene location

GeneLoc information about chromosome 19         GeneLoc Exon Structure

GeneLoc location for GC19P000752:  view genomic region     (about GC identifiers)

Start:
751,126 bp from pter      End:
764,319 bp from pter
Size:
13,194 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: MISP_HUMAN, Q8IVT2 (See protein sequence)
Recommended Name: Mitotic interactor and substrate of PLK1  
Size: 679 amino acids; 75357 Da
Subunit: Associates with F-actin. Interacts with DCTN1; this interaction regulates DCTN1 distribution at the cell
cortex. Interacts with PTK2/FAK and MAPRE1
Developmental stage: Regulated in a cell-cycle dependent manner. Weakly expressed in G1 and S phases. Expression
increases in G2/M phases and persisting until the end of mitosis (at protein level)

Explore the universe of human proteins at neXtProt for MISP: NX_Q8IVT2

Explore proteomics data for MISP at MOPED

Post-translational modifications: 

  • Phosphorylated by CDK1 and PLK1. CDK1 is the priming kinase for PLK1 phosphorylation. Phosphorylation by PLK1 is
    required for proper spindle orientation at metaphase1
  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See MISP Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_775752.1  
    ENSEMBL proteins: 
     ENSP00000215582  

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    ProtoNet protein and cluster: Q8IVT2


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: MISP_HUMAN, Q8IVT2
    Function: Plays a role in mitotic spindle orientation and mitotic progression. Regulates the distribution of
    dynactin at the cell cortex in a PLK1-dependent manner, thus stabilizing cortical and astral microtubule
    attachments required for proper mitotic spindle positioning. May link microtubules to the actin cytospkeleton and
    focal adhesions. May be required for directed cell migration and centrosome orientation. May also be necessary
    for proper stacking of the Golgi apparatus

         Gene Ontology (GO): 1 molecular function term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003779actin binding IEA--
         
    Find genes that share ontologies with MISP           About GenesLikeMe


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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    MISP_HUMAN, Q8IVT2: Cell junction, focal adhesion. Cytoplasm, cytoskeleton. Cytoplasm, cell cortex.
    Note=Predominantly localizes to cortical actin structures during interphase and mitosis. Present in retraction
    fibers, which are formed at former adhesion sites during mitosis, and at spicular membrane protrusions in
    re-attaching cytokinetic cells. Partially colocalizes with cytoplasmic F-actin. Not detected at microtubules at
    interphase, nor at spindle during mitosis

    Gene Ontology (GO): 3 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005856cytoskeleton IEA--
    GO:0005925focal adhesion IEA--
    GO:0005938cell cortex IEA--

    Find genes that share ontologies with MISP           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for MISP
    Interactions:

        Search GeneGlobe Interaction Network for MISP

    Gene Ontology (GO): 1 biological process term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0007067mitosis IEA--

    Find genes that share ontologies with MISP           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for MISP



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for MISP gene: 
    NM_173481.2  

    1 Ensembl transcript including schematic representation, and UCSC links where relevant:
    ENST00000215582(uc002lpo.3)
    miRNA
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    Selected AceView cDNA sequences (see all 105):

    AI669065 BM920855 AA576490 AW387920 BX648815 BC052236 BU196390 BQ944821 
    NM_173481 BC042125 AW081312 BQ687660 BM983228 AA552431 AA586357 BU527494 
    AA367214 BI823665 AW204476 AA970439 AA327165 AI660442 BI255843 AL577971 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    MISP expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    MISP Expression
    About this image


    MISP expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 3) fully expand
     
     Ovary (Reproductive System)
             Secondary Oocyte Antral Follicle
     
     Gonad
             Secondary Oocyte Antral Follicle
     
     Colon (Gastrointestinal Tract)
    MISP Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    MISP Protein Expression
        Custom PCR Arrays for MISP
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MISP

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for MISP gene from Selected species (see all 10)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia 9130017N09Rik5
    Misp1
    RIKEN cDNA 9130017N09 gene5
    mitotic spindle positioning1
    72.59(n)1
    66.67(a)1
      10 (39.72 cM)5
    789061  NM_030218.21  NP_084494.11 
     798210215 
    chicken
    (Gallus gallus)
    Aves C28H19ORF211 chromosome 28 open reading frame, human C19orf21 54.87(n)
    43.71(a)
      420097  XM_418218.4  XP_418218.4 
    lizard
    (Anolis carolinensis)
    Reptilia MISP6
    mitotic spindle positioning
    33(a)
    1 ↔ 1
    GL344414.1(9908-11320)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia misp1 mitotic spindle positioning 41.67(n)
    32.06(a)
      100497332  XM_002937383.2  XP_002937429.1 


    ENSEMBL Gene Tree for MISP (if available)
    TreeFam Gene Tree for MISP (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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      --

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for MISP (see all 549)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 19 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs124594721,2
    C,F,A,H--749190(+) CAGCCT/CGGGCG 1 -- us2k110Minor allele frequency- C:0.35NA WA CSA EA 372
    rs1155915491,2
    C--749195(+) TGGGCA/GTGGGA 1 -- us2k10--------
    rs1381829211,2
    --749201(+) TGGGAC/TGTCTC 1 -- us2k10--------
    rs1897754501,2
    --749225(+) GCTCAC/TGGGCG 1 -- us2k10--------
    rs1495124671,2
    --749298(+) GCACTA/GCTGAG 1 -- us2k10--------
    rs1459154301,2
    C--749299(+) CACTGA/CTGAGG 1 -- us2k10--------
    rs771991631,2
    C,F--749331(+) CCTAAA/CCCCCC 1 -- us2k12Minor allele frequency- C:0.25WA EA 238
    rs752225881,2
    C,F--749386(+) CCTATC/TTACAA 1 -- us2k11Minor allele frequency- T:0.03EA 120
    rs1817718351,2
    --749423(+) GTGGCC/GGGAGG 1 -- us2k10--------
    rs1851578721,2
    --749424(+) TGGCGG/TGAGGC 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for MISP (751126 - 764319 bp)

    Structural Variations
          Database of Genomic Variants (DGV) variations for MISP: --
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing MISP
    DNA2.0 Custom Variant and Variant Library Synthesis for MISP

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 615289    OMIM disorders: --


    Find genes that share disorders with MISP           About GenesLikeMe


    Export disorders for MISP gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for MISP gene, integrated from 10 sources (see all 16):
    (articles sorted by number of sources associating them with MISP)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. MISP is a novel Plk1 substrate required for proper spindle orientation and mitotic progression. (PubMed id 23509069)1, 2, 3 Zhu M.... Hoffmann I. (J. Cell Biol. 2013)
    2. The novel actin/focal adhesion-associated protein MISP is involved in mitotic spindle positioning in human cells. (PubMed id 23574715)1, 2, 3 Maier B.... Kraemer A. (Cell Cycle 2013)
    3. Caprice/MISP is a novel F-actin bundling protein critical for actin-based cytoskeletal reorganizations. (PubMed id 24475924)1, 3 Kumeta M....Takeyasu K. (amp 2014)
    4. Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PubMed id 17081983)1, 2 Olsen J.V....Mann M. (Cell 2006)
    5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    6. A functional genomic approach reveals the transcriptional role of EDD in the expression and function of angiogenesis regulator ACVRL1. (PubMed id 24189493)1 Chen H.W....Tan B.C. (Biochim. Biophys. Acta 2013)
    7. Mass spectrometric analysis of lysine ubiquitylation reveals promiscuity at site level. (PubMed id 21139048)1 Danielsen J.M....Nielsen M.L. (amp 2011)
    8. Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis. (PubMed id 20068231)2 Olsen J.V....Mann M. (Sci. Signal. 2010)
    9. Systematic analysis of human protein complexes identifies chromosome segregation proteins. (PubMed id 20360068)1 Hutchins J.R.... Peters J.M. (Science 2010)
    10. Proteomic and targeted analytical identification of BXDC1 and EBNA1BP2 as dynamic scaffold proteins in the nucleolus. (PubMed id 19170763)1 Hirano Y.... Horigome T. (Genes Cells 2009)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 126353 HGNC: 27000 AceView: C19orf21 Ensembl:ENSG00000099812 euGenes: HUgn126353
    ECgene: MISP H-InvDB: MISP

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for MISP Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for MISP gene:
    Search GeneIP for patents involving MISP

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
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     Custom PCR Arrays for MISP Search Chromatin IP Primers for MISP
     Search Pre-validated RT2 qPCR Primer Assays in human, mouse, rat MISP Search GeneGlobe Interaction Network for MISP
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     GenScript Custom Purified and Recombinant Proteins Services for MISP GenScript Custom cDNA clones with any tag delivered in your preferred vector Services for MISP
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     Search for Antibodies & Assays

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     Browse Sino Biological Proteins
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     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

     Novus Tissue Slides
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     Search for Antibodies for MISP at Abcam
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     Browse ESI BIO Cell Lines and PureStem Progenitors for MISP
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     inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for MISP
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     LSBio Antibodies in human, mouse, rat for MISP
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     Browse compounds at ApexBio
     Search Addgene for plasmids for MISP
      Search eBioscience for proteins for MISP
      Search eBioscience for elisas for MISP
      eBioscience FlowRNA Probe Sets
           
    GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014 , 21 Aug 2014 , 8 Sep 2014

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