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Aliases for MIS18BP1 Gene

Aliases for MIS18BP1 Gene

  • MIS18 Binding Protein 1 2 3
  • Kinetochore-Associated Protein KNL-2 Homolog 3 4
  • C14orf106 3 4
  • HsKNL-2 3 4
  • M18BP1 3 4
  • KNL2 3 4
  • P243 3 4
  • Putative Protein P243 Which Interacts With Transcription Factor Sp1 3
  • Kinetochore Null 2 Homolog (C. Elegans) 2
  • Chromosome 14 Open Reading Frame 106 2
  • Kinetochore Null 2 Homolog 3
  • Mis18-Binding Protein 1 3
  • HSA242977 3
  • KIAA1903 4

External Ids for MIS18BP1 Gene

Previous Symbols for MIS18BP1 Gene

  • C14orf106

Summaries for MIS18BP1 Gene

GeneCards Summary for MIS18BP1 Gene

MIS18BP1 (MIS18 Binding Protein 1) is a Protein Coding gene. Among its related pathways are Cell Cycle, Mitotic and Packaging Of Telomere Ends. GO annotations related to this gene include chromatin binding.

UniProtKB/Swiss-Prot for MIS18BP1 Gene

  • Required for recruitment of CENPA to centromeres and normal chromosome segregation during mitosis.

Gene Wiki entry for MIS18BP1 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MIS18BP1 Gene

Genomics for MIS18BP1 Gene

Genomic Location for MIS18BP1 Gene

Start:
45,203,190 bp from pter
End:
45,253,540 bp from pter
Size:
50,351 bases
Orientation:
Minus strand

Genomic View for MIS18BP1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for MIS18BP1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIS18BP1 Gene

No data available for Regulatory Elements for MIS18BP1 Gene

Proteins for MIS18BP1 Gene

  • Protein details for MIS18BP1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q6P0N0-M18BP_HUMAN
    Recommended name:
    Mis18-binding protein 1
    Protein Accession:
    Q6P0N0
    Secondary Accessions:
    • D3DSA7
    • Q86V14
    • Q96PY4
    • Q9NUR5
    • Q9Y4X9

    Protein attributes for MIS18BP1 Gene

    Size:
    1132 amino acids
    Molecular mass:
    129085 Da
    Quaternary structure:
    • Interacts (via N-terminus) with FLNA (via N-terminus) (By similarity). Interacts with SP1 (Probable). Interacts with MIS18A. Identified in a complex containing MIS18A, MIS18B, MIS18BP1, RBBP7 and RBBP4.
    SequenceCaution:
    • Sequence=AK002048; Type=Frameshift; Positions=157; Evidence={ECO:0000305}; Sequence=BAB67796.1; Type=Frameshift; Positions=154; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for MIS18BP1 Gene

    Alternative splice isoforms for MIS18BP1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for MIS18BP1 Gene

Proteomics data for MIS18BP1 Gene at MOPED

Post-translational modifications for MIS18BP1 Gene

  • Modification sites at PhosphoSitePlus
  • Ubiquitination at Lys65, Lys113, Lys458, Lys647, Lys850, Lys1066, and Lys1093

Other Protein References for MIS18BP1 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

No data available for DME Specific Peptides for MIS18BP1 Gene

Domains for MIS18BP1 Gene

Protein Domains for MIS18BP1 Gene

UniProtKB/Swiss-Prot:

M18BP_HUMAN
Domain:
  • Contains 1 SANT domain.:
    • Q6P0N0
genes like me logo Genes that share domains with MIS18BP1: view

No data available for Gene Families for MIS18BP1 Gene

Function for MIS18BP1 Gene

Molecular function for MIS18BP1 Gene

UniProtKB/Swiss-Prot Function: Required for recruitment of CENPA to centromeres and normal chromosome segregation during mitosis.

Gene Ontology (GO) - Molecular Function for MIS18BP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 DNA binding IEA --
GO:0003682 chromatin binding IEA --
GO:0005515 protein binding IPI 17199038
genes like me logo Genes that share ontologies with MIS18BP1: view

miRNA for MIS18BP1 Gene

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , Transcription Factor Targeting and HOMER Transcription for MIS18BP1 Gene

Localization for MIS18BP1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for MIS18BP1 Gene

Nucleus. Chromosome. Chromosome, centromere. Note=Associated with centromeres in interphase cells, from late anaphase to the G1 phase. Not detected on centromeres during earlier phases of mitosis. Associated with chromatin.

Gene Ontology (GO) - Cellular Components for MIS18BP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000775 chromosome, centromeric region IEA --
GO:0005654 nucleoplasm TAS --
genes like me logo Genes that share ontologies with MIS18BP1: view

Pathways for MIS18BP1 Gene

genes like me logo Genes that share pathways with MIS18BP1: view

Pathways by source for MIS18BP1 Gene

Gene Ontology (GO) - Biological Process for MIS18BP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006334 nucleosome assembly TAS --
GO:0007067 mitotic nuclear division IEA --
GO:0034080 CENP-A containing nucleosome assembly TAS --
GO:0051301 cell division IEA --
genes like me logo Genes that share ontologies with MIS18BP1: view

Transcripts for MIS18BP1 Gene

Unigene Clusters for MIS18BP1 Gene

MIS18 binding protein 1:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for MIS18BP1 Gene

ExUns: 1 ^ 2 ^ 3a · 3b ^ 4 ^ 5a · 5b · 5c ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11a · 11b ^ 12 ^ 13a · 13b ^ 14 ^ 15 ^ 16a · 16b ^ 17a · 17b ^ 18a · 18b ^
SP1: - -
SP2: - - -
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:

ExUns: 19
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:

Relevant External Links for MIS18BP1 Gene

GeneLoc Exon Structure for
MIS18BP1
ECgene alternative splicing isoforms for
MIS18BP1

Expression for MIS18BP1 Gene

mRNA expression in normal human tissues for MIS18BP1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for MIS18BP1 Gene

SOURCE GeneReport for Unigene cluster for MIS18BP1 Gene Hs.732769

genes like me logo Genes that share expressions with MIS18BP1: view

Orthologs for MIS18BP1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for MIS18BP1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia MIS18BP1 36
  • 99.47 (n)
  • 98.76 (a)
MIS18BP1 37
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia MIS18BP1 36
  • 83.7 (n)
  • 73.72 (a)
MIS18BP1 37
  • 70 (a)
OneToOne
dog
(Canis familiaris)
Mammalia MIS18BP1 36
  • 85.15 (n)
  • 73.43 (a)
MIS18BP1 37
  • 72 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Mis18bp1 36
  • 72.96 (n)
  • 57.03 (a)
Mis18bp1 16
Mis18bp1 37
  • 56 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia -- 37
  • 34 (a)
OneToMany
-- 37
  • 47 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia MIS18BP1 37
  • 33 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Mis18bp1 36
  • 74.45 (n)
  • 59.06 (a)
chicken
(Gallus gallus)
Aves MIS18BP1 37
  • 30 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia MIS18BP1 37
  • 30 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.15885 36
zebrafish
(Danio rerio)
Actinopterygii MIS18BP1 37
  • 20 (a)
OneToOne
Species with no ortholog for MIS18BP1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for MIS18BP1 Gene

ENSEMBL:
Gene Tree for MIS18BP1 (if available)
TreeFam:
Gene Tree for MIS18BP1 (if available)

Paralogs for MIS18BP1 Gene

No data available for Paralogs for MIS18BP1 Gene

Variants for MIS18BP1 Gene

Sequence variations from dbSNP and Humsavar for MIS18BP1 Gene

SNP ID Clin Chr 14 pos Sequence Context AA Info Type MAF
rs941878 -- 45,245,331(-) aagat(G/T)gtgag intron-variant
rs1000048 -- 45,235,806(+) GACAG(A/T)CATTT intron-variant
rs1252955 -- 45,255,474(-) gctta(C/T)ttttc upstream-variant-2KB
rs1252956 -- 45,255,332(-) ccaat(C/T)agcac upstream-variant-2KB
rs1252957 -- 45,253,811(-) AGCGA(A/G)ACCCT upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for MIS18BP1 Gene

Variant ID Type Subtype PubMed ID
nsv901841 CNV Loss 21882294
nsv901842 CNV Loss 21882294
nsv901843 CNV Gain 21882294
nsv832785 CNV Loss 17160897
nsv901844 CNV Loss 21882294
nsv901845 CNV Loss 21882294
esv2748677 CNV Deletion 23290073
esv2748678 CNV Deletion 23290073
nsv901846 CNV Loss 21882294
dgv631e1 CNV Complex 17122850

Relevant External Links for MIS18BP1 Gene

HapMap Linkage Disequilibrium report
MIS18BP1

Disorders for MIS18BP1 Gene

No disorders were found for MIS18BP1 Gene.

No data available for UniProtKB/Swiss-Prot for MIS18BP1 Gene

Publications for MIS18BP1 Gene

  1. Priming of centromere for CENP-A recruitment by human hMis18alpha, hMis18beta, and M18BP1. (PMID: 17199038) Fujita Y. … Yanagida M. (Dev. Cell 2007) 2 3 4
  2. Functional genomics identifies a Myb domain-containing protein family required for assembly of CENP-A chromatin. (PMID: 17339379) Maddox P.S. … Desai A. (J. Cell Biol. 2007) 2 3 4
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  5. A set of proteins interacting with transcription factor Sp1 identified in a two-hybrid screening. (PMID: 10976766) Gunther M. … Brison O. (Mol. Cell. Biochem. 2000) 3 4

Products for MIS18BP1 Gene

Sources for MIS18BP1 Gene

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