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MIS18A Gene

protein-coding   GIFtS: 49
GCID: GC21M033641

MIS18 Kinetochore Protein A

(Previous names: chromosome 21 open reading frame 46, chromosome 21 open...)
(Previous symbols: C21orf46, C21orf45)
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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
MIS18 Kinetochore Protein A1 2     MIS18 Kinetochore Protein Homolog A (S. Pombe)1
C21orf451 2 3     B282
C21orf461 2 3     MIS18alpha2
FASP12 3     hMis18alpha2
FAPP1-Associated Protein 12 3     MIS18 Kinetochore Protein Homolog A2
Chromosome 21 Open Reading Frame 451     Protein Mis18-Alpha2
Chromosome 21 Open Reading Frame 461     

External Ids:    HGNC: 12861   Entrez Gene: 540692   Ensembl: ENSG000001590557   UniProtKB: Q9NYP93   

Export aliases for MIS18A gene to outside databases


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for MIS18A Gene:
MIS18A (MIS18 kinetochore protein A) is a protein-coding gene.

UniProtKB/Swiss-Prot: MS18A_HUMAN, Q9NYP9
Function: Required for recruitment of CENPA to centromeres and normal chromosome segregation during mitosis

Gene Wiki entry for MIS18A (C21orf45) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000021.8  NC_018932.2  NT_011512.12  
Regulatory elements:
   Search for regulatory transcription factor binding sites for MIS18A
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search Chromatin IP Primers for MIS18A

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat MIS18A


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 21q22.11   Ensembl cytogenetic band:  21q22.11   HGNC cytogenetic band: 21q22.11

MIS18A Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
MIS18A gene location

GeneLoc information about chromosome 21         GeneLoc Exon Structure

GeneLoc location for GC21M033641:  view genomic region     (about GC identifiers)

Start:
33,640,530 bp from pter      End:
33,651,380 bp from pter
Size:
10,851 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: MS18A_HUMAN, Q9NYP9 (See protein sequence)
Recommended Name: Protein Mis18-alpha  
Size: 233 amino acids; 25863 Da
Subunit: Homodimer, and heterodimer with MIS18B. Identified in a complex containing MIS18A, MIS18B, MIS18BP1,
RBBP7 and RBBP4
Secondary accessions: B2R562 Q542Z0

Explore the universe of human proteins at neXtProt for MIS18A: NX_Q9NYP9

Explore proteomics data for MIS18A at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys130, Lys203, Lys213, Lys218, Lys232
  • Modification sites at PhosphoSitePlus

  • See MIS18A Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_061817.1  
    ENSEMBL proteins: 
     ENSP00000290130  
    Reactome Protein details: Q9NYP9

    MIS18A Human Recombinant Protein Products:

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    Browse Sino Biological Recombinant Proteins
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    Browse Proteins at Cloud-Clone Corp.

     
    Search eBioscience for Proteins for MIS18A 

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    Browse Enzo Life Sciences for kits & assays
    Browse ELISAs at Cloud-Clone Corp.
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    Search eBioscience for ELISAs for MIS18A 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    1 InterPro protein domain:
     IPR004910 Yippee/Mis18

    Graphical View of Domain Structure for InterPro Entry Q9NYP9

    ProtoNet protein and cluster: Q9NYP9

    UniProtKB/Swiss-Prot: MS18A_HUMAN, Q9NYP9
    Similarity: Belongs to the mis18 family


    Find genes that share domains with MIS18A           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: MS18A_HUMAN, Q9NYP9
    Function: Required for recruitment of CENPA to centromeres and normal chromosome segregation during mitosis

         Gene Ontology (GO): 2 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003674molecular_function ND--
    GO:0005515protein binding ----
         
    Find genes that share ontologies with MIS18A           About GenesLikeMe


    Phenotypes:
         1 GenomeRNAi human phenotype for MIS18A:
     Synthetic lethal with Ras 

         4 MGI mutant phenotypes (inferred from 2 alleles(MGI details for Mis18a):
     cellular  embryogenesis  mortality/aging  no phenotypic analysis 

    Find genes that share phenotypes with MIS18A           About GenesLikeMe

    Animal Models:
         MGI mouse knock-out Mis18atm1.2Kiik for MIS18A

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for MIS18A
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for MIS18A

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for MIS18A
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for MIS18A

    miRNA
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    miRTarBase miRNAs that target MIS18A:
    hsa-mir-24-3p (MIRT030399), hsa-mir-505-5p (MIRT037952)

    Block miRNA regulation of human, mouse, rat MIS18A using miScript Target Protectors
    1 qRT-PCR Assays for microRNA that regulate MIS18A:
    hsa-miR-607
    SwitchGear 3'UTR luciferase reporter plasmidMIS18A 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat MIS18A

    Gene Editing
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    GenScript: all cDNA clones in your preferred vector: MIS18A (NM_018944)
    Browse Sino Biological Human cDNA Clones
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MIS18A

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    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MIS18A


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    MS18A_HUMAN, Q9NYP9: Nucleus. Chromosome. Chromosome, centromere. Note=Associated with centromeres in interphase
    cells, from late anaphase to the G1 phase. Not detected on centromeres during earlier phases of mitosis.
    Associated with chromatin

    Gene Ontology (GO): 4 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000775chromosome, centromeric region IEA--
    GO:0005634nucleus IDA--
    GO:0005654nucleoplasm TAS--
    GO:0005737cytoplasm IDA--

    Find genes that share ontologies with MIS18A           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for MIS18A About    
    See pathways by source

    SuperPathContained pathways About
    1Packaging Of Telomere Ends
    Chromosome Maintenance0.62
    Deposition of New CENPA-containing Nucleosomes at the Centromere0.59
    Nucleosome assembly0.59
    2Cell Cycle, Mitotic
    Cell Cycle0.90


    Find genes that share SuperPaths with MIS18A           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 Reactome Pathway for MIS18A
        Deposition of new CENPA-containing nucleosomes at the centromere


        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for MIS18A
    Interactions:

        Search GeneGlobe Interaction Network for MIS18A

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for MIS18A (Q9NYP93 ENSP000002901304) via UniProtKB, MINT, STRING, and/or I2D (see all 32)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    NDEL1Q9GZM83, ENSP000003339824I2D: score=2 STRING: ENSP00000333982
    OIP5O434823, ENSP000002205144I2D: score=1 STRING: ENSP00000220514
    CASC5ENSP000003354634STRING: ENSP00000335463
    CENPHENSP000002830064STRING: ENSP00000283006
    CENPIENSP000002185074STRING: ENSP00000218507
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006334nucleosome assembly TAS--
    GO:0007059chromosome segregation IEA--
    GO:0007067mitosis IEA--
    GO:0008150biological_process ND--
    GO:0034080CENP-A containing nucleosome assembly at centromere TAS--

    Find genes that share ontologies with MIS18A           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for MIS18A (MS18A)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for MIS18A gene: 
    NM_018944.2  

    Unigene Cluster for MIS18A:

    MIS18 kinetochore protein homolog A (S. pombe)
    Hs.190518  [show with all ESTs]
    Unigene Representative Sequence: NM_018944
    2 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000290130(uc002ypi.3) ENST00000486363
    miRNA
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    1 qRT-PCR Assays for microRNA that regulate MIS18A:
    hsa-miR-607
    SwitchGear 3'UTR luciferase reporter plasmidMIS18A 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for MIS18A
    Predesigned siRNA for gene silencing in human, mouse, rat MIS18A
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    GenScript: all cDNA clones in your preferred vector: MIS18A (NM_018944)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for MIS18A
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MIS18A
    Primer
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    OriGene qPCR primer pairs and template standards for MIS18A
    OriGene qSTAR qPCR primer pairs in human, mouse for MIS18A
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat MIS18A
      QuantiTect SYBR Green Assays in human, mouse, rat MIS18A
      QuantiFast Probe-based Assays in human, mouse, rat MIS18A

    Additional mRNA sequence: 

    AF231921.1 AF387845.1 AK075281.1 AK312073.1 BC042917.1 

    5 DOTS entries:

    DT.442708  DT.95270777  DT.121138506  DT.95270775  DT.442707 

    Selected AceView cDNA sequences (see all 96):

    CK902536 BM749264 BF109083 AA709257 CA418285 BQ051963 AA807728 BE796164 
    AI652030 BI226071 AF231921 BC042917 BX119805 BM758045 BU623181 BF059324 
    BQ014318 BE275345 NM_018944 BQ022599 AF387845 AA613716 AK075281 BM912161 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    MIS18A expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GAATCTTCTC
    MIS18A Expression
    About this image


    MIS18A expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 2) fully expand
     
     Brain (Nervous System)    fully expand to see all 4 entries
             Cerebral Cortex
     
     Neural Tube (Nervous System)    fully expand to see all 2 entries
             Telencephalon
    MIS18A Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    MIS18A Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.190518

    UniProtKB/Swiss-Prot: MS18A_HUMAN, Q9NYP9
    Tissue specificity: Detected in testis

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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MIS18A

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for MIS18A gene from Selected species (see all 10)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Mis18a1 , 5 RIKEN cDNA 2610039C10 gene5
    MIS18 kinetochore protein homolog A (S. pombe)1
    80.07(n)1
    77.89(a)1
      16 (51.87 cM)5
    665781  NM_025642.11  NP_079918.11 
     907193125 
    chicken
    (Gallus gallus)
    Aves MIS18A1 MIS18 kinetochore protein homolog A (S. pombe) 68.26(n)
    63.01(a)
      418494  XM_416702.4  XP_416702.1 
    lizard
    (Anolis carolinensis)
    Reptilia MIS18A6
    MIS18 kinetochore protein A
    46(a)
    1 ↔ 1
    3(145377006-145385992)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia mis18a1 MIS18 kinetochore protein homolog A (S. pombe) 55.33(n)
    46.26(a)
      100486195  XM_002938442.2  XP_002938488.2 
    zebrafish
    (Danio rerio)
    Actinopterygii mis18a1 MIS18 kinetochore protein homolog A (S. pombe) 52.15(n)
    41.5(a)
      553502  XM_002663588.2  XP_002663634.2 


    ENSEMBL Gene Tree for MIS18A (if available)
    TreeFam Gene Tree for MIS18A (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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      --

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for MIS18A (see all 285)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 21 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1497754471,2
    --33640079(+) TACATC/TGAGCT 1 -- ds50010--------
    rs1457263181,2
    C--33640116(+) CCAGCA/GGGTGT 1 -- ds50010--------
    rs1489229111,2
    C--33640182(+) AGAACA/GCCTAA 1 -- ds50010--------
    rs1856764941,2
    C--33640200(+) ACTCAA/GCGTTA 1 -- ds50010--------
    rs1174585671,2
    C,F--33640218(+) CTGTCG/AACAAT 1 -- ds50011Minor allele frequency- A:0.02NA 120
    rs1905500131,2
    --33640333(+) GCAAAC/TGCTGA 1 -- ds50010--------
    rs759748961,2
    --33640365(+) TGTTCC/TGTGAC 1 -- ds50010--------
    rs731911571,2
    --33640366(+) GTTCCA/GTGACC 1 -- ds50010--------
    rs1158823531,2
    F--33640462(+) AGTAAT/GGTGTG 1 -- ds50011Minor allele frequency- G:0.03WA 118
    rs31779921,2
    C--33640543(-) TTAAAA/CCAAAG 1 -- ut31 ese31Minor allele frequency- C:0.00NA 2

    HapMap Linkage Disequilibrium report for MIS18A (33640530 - 33651380 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 2 variations for MIS18A:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv510795CNV Loss20534489
    nsv834084CNV Gain17160897

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing MIS18A
    DNA2.0 Custom Variant and Variant Library Synthesis for MIS18A

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for MIS18A gene, integrated from 10 sources (see all 24):
    (articles sorted by number of sources associating them with MIS18A)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Priming of centromere for CENP-A recruitment by human hMis18alpha, hMis18beta, and M18BP1. (PubMed id 17199038)1, 2, 3 Fujita Y....Yanagida M. (Dev. Cell 2007)
    2. Signal sequence and keyword trap in silico for selection of full- length human cDNAs encoding secretion or membrane proteins from oligo- capped cDNA libraries. (PubMed id 16303743)1, 2 Otsuki T....Isogai T. (DNA Res. 2005)
    3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    4. Criteria for gene identification and features of genome organization: analysis of 6.5 Mb of DNA sequence from human chromosome 21. (PubMed id 10773462)1, 2 Slavov D.... Gardiner K. (Gene 2000)
    5. PP5644 interacts with phosphatidylinositol-4-phosphate adaptor protein-1 associated protein-1. (PubMed id 15881666)1, 9 Ye X.-X.... Gu J.-R. (Mol. Cell. Biochem. 2005)
    6. Pathway Analysis of ChIP-Seq-Based NRF1 Target Genes Suggests a Logical Hypothesis of their Involvement in the Pathogenesis of Neurodegenerative Diseases. (PubMed id 24250222)1 Satoh J....Yamamoto Y. (Gene Regul Syst Bio 2013)
    7. Systems-wide analysis of ubiquitylation dynamics reveals a key role for PAF15 ubiquitylation in DNA-damage bypass. (PubMed id 23000965)1 Povlsen L.K....Choudhary C. (Nat. Cell Biol. 2012)
    8. Methods for quantification of in vivo changes in protein ubiquitination following proteasome and deubiquitinase inhibition. (PubMed id 22505724)1 Udeshi N.D....Carr S.A. (amp 2012)
    9. A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles. (PubMed id 21890473)1 Wagner S.A....Choudhary C. (amp 2011)
    10. Toward an understanding of the protein interaction network of the human liver. (PubMed id 21988832)1 Wang J....Yang X. (Mol. Syst. Biol. 2011)

    (in PubMed, OMIM, and NCBI Bookshelf)
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 54069 HGNC: 1286 AceView: C21orf45 Ensembl:ENSG00000159055 euGenes: HUgn54069
    ECgene: MIS18A H-InvDB: MIS18A

    (According to HUGE)
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    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for MIS18A Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for MIS18A gene:
    Search GeneIP for patents involving MIS18A

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
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