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Aliases for MIS18A Gene

Aliases for MIS18A Gene

  • MIS18 Kinetochore Protein A 2 3 5
  • FAPP1-Associated Protein 1 3 4
  • C21orf45 3 4
  • C21orf46 3 4
  • FASP1 3 4
  • MIS18 Kinetochore Protein Homolog A (S. Pombe) 2
  • Chromosome 21 Open Reading Frame 46 2
  • Chromosome 21 Open Reading Frame 45 2
  • MIS18 Kinetochore Protein Homolog A 3
  • HMis18alpha 3
  • MIS18alpha 3
  • B28 3

External Ids for MIS18A Gene

Previous HGNC Symbols for MIS18A Gene

  • C21orf46
  • C21orf45

Previous GeneCards Identifiers for MIS18A Gene

  • GC21M033641

Summaries for MIS18A Gene

GeneCards Summary for MIS18A Gene

MIS18A (MIS18 Kinetochore Protein A) is a Protein Coding gene. Among its related pathways are Cell Cycle, Mitotic and Chromosome Maintenance.

UniProtKB/Swiss-Prot for MIS18A Gene

  • Required for recruitment of CENPA to centromeres and normal chromosome segregation during mitosis.

Gene Wiki entry for MIS18A Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MIS18A Gene

Genomics for MIS18A Gene

Regulatory Elements for MIS18A Gene

Promoters for MIS18A Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around MIS18A on UCSC Golden Path with GeneCards custom track

Genomic Location for MIS18A Gene

Chromosome:
21
Start:
32,268,219 bp from pter
End:
32,279,069 bp from pter
Size:
10,851 bases
Orientation:
Minus strand

Genomic View for MIS18A Gene

Genes around MIS18A on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MIS18A Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIS18A Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIS18A Gene

Proteins for MIS18A Gene

  • Protein details for MIS18A Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9NYP9-MS18A_HUMAN
    Recommended name:
    Protein Mis18-alpha
    Protein Accession:
    Q9NYP9
    Secondary Accessions:
    • B2R562
    • Q542Z0

    Protein attributes for MIS18A Gene

    Size:
    233 amino acids
    Molecular mass:
    25863 Da
    Quaternary structure:
    • Homodimer, and heterodimer with MIS18B. Identified in a complex containing MIS18A, MIS18B, MIS18BP1, RBBP7 and RBBP4.

neXtProt entry for MIS18A Gene

Proteomics data for MIS18A Gene at MOPED

Post-translational modifications for MIS18A Gene

  • Ubiquitination at Lys 130, Lys 203, Lys 213, Lys 218, and Lys 232
  • Modification sites at PhosphoSitePlus

Other Protein References for MIS18A Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for MIS18A Gene

Domains & Families for MIS18A Gene

Protein Domains for MIS18A Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for MIS18A Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9NYP9

UniProtKB/Swiss-Prot:

MS18A_HUMAN :
  • Belongs to the mis18 family.
Family:
  • Belongs to the mis18 family.
genes like me logo Genes that share domains with MIS18A: view

No data available for Gene Families for MIS18A Gene

Function for MIS18A Gene

Molecular function for MIS18A Gene

UniProtKB/Swiss-Prot Function:
Required for recruitment of CENPA to centromeres and normal chromosome segregation during mitosis.

Gene Ontology (GO) - Molecular Function for MIS18A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003674 molecular_function ND --
genes like me logo Genes that share ontologies with MIS18A: view

Phenotypes for MIS18A Gene

MGI mutant phenotypes for MIS18A:
inferred from 2 alleles
GenomeRNAi human phenotypes for MIS18A:
genes like me logo Genes that share phenotypes with MIS18A: view

Animal Models for MIS18A Gene

MGI Knock Outs for MIS18A:

Animal Model Products

CRISPR Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for MIS18A Gene

Localization for MIS18A Gene

Subcellular locations from UniProtKB/Swiss-Prot for MIS18A Gene

Nucleus. Chromosome. Chromosome, centromere. Note=Associated with centromeres in interphase cells, from late anaphase to the G1 phase. Not detected on centromeres during earlier phases of mitosis. Associated with chromatin.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for MIS18A Gene COMPARTMENTS Subcellular localization image for MIS18A gene
Compartment Confidence
nucleus 5
cytosol 3
extracellular 1
mitochondrion 1
plasma membrane 1

Gene Ontology (GO) - Cellular Components for MIS18A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IDA --
genes like me logo Genes that share ontologies with MIS18A: view

Pathways & Interactions for MIS18A Gene

genes like me logo Genes that share pathways with MIS18A: view

Gene Ontology (GO) - Biological Process for MIS18A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006334 nucleosome assembly TAS --
GO:0007059 chromosome segregation IEA --
GO:0008150 biological_process ND --
GO:0034080 CENP-A containing nucleosome assembly IEA,TAS --
GO:0051301 cell division IEA --
genes like me logo Genes that share ontologies with MIS18A: view

No data available for SIGNOR curated interactions for MIS18A Gene

Drugs & Compounds for MIS18A Gene

No Compound Related Data Available

Transcripts for MIS18A Gene

mRNA/cDNA for MIS18A Gene

Unigene Clusters for MIS18A Gene

MIS18 kinetochore protein homolog A (S. pombe):
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for MIS18A Gene

No ASD Table

Relevant External Links for MIS18A Gene

GeneLoc Exon Structure for
MIS18A
ECgene alternative splicing isoforms for
MIS18A

Expression for MIS18A Gene

mRNA expression in normal human tissues for MIS18A Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for MIS18A Gene

This gene is overexpressed in Ovary (35.7), Testis (26.0), and Fetal ovary (6.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for MIS18A Gene



SOURCE GeneReport for Unigene cluster for MIS18A Gene Hs.190518

mRNA Expression by UniProt/SwissProt for MIS18A Gene

Q9NYP9-MS18A_HUMAN
Tissue specificity: Detected in testis.
genes like me logo Genes that share expression patterns with MIS18A: view

Protein tissue co-expression partners for MIS18A Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA differential expression in normal tissues for MIS18A Gene

Orthologs for MIS18A Gene

This gene was present in the common ancestor of chordates.

Orthologs for MIS18A Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia MIS18A 35
  • 83.4 (n)
  • 79.4 (a)
MIS18A 36
  • 80 (a)
OneToOne
dog
(Canis familiaris)
Mammalia MIS18A 35
  • 85.23 (n)
  • 80.26 (a)
MIS18A 36
  • 75 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Mis18a 35
  • 80.07 (n)
  • 77.89 (a)
Mis18a 16
Mis18a 36
  • 75 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia MIS18A 35
  • 98.56 (n)
  • 98.28 (a)
MIS18A 36
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Mis18a 35
  • 77.93 (n)
  • 74.89 (a)
oppossum
(Monodelphis domestica)
Mammalia MIS18A 36
  • 29 (a)
OneToOne
chicken
(Gallus gallus)
Aves MIS18A 35
  • 68.26 (n)
  • 63.01 (a)
MIS18A 36
  • 53 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia MIS18A 36
  • 46 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia mis18a 35
  • 55.33 (n)
  • 46.26 (a)
zebrafish
(Danio rerio)
Actinopterygii mis18a 35
  • 52.15 (n)
  • 41.5 (a)
mis18a 36
  • 35 (a)
OneToOne
Species with no ortholog for MIS18A:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for MIS18A Gene

ENSEMBL:
Gene Tree for MIS18A (if available)
TreeFam:
Gene Tree for MIS18A (if available)

Paralogs for MIS18A Gene

No data available for Paralogs for MIS18A Gene

Variants for MIS18A Gene

Sequence variations from dbSNP and Humsavar for MIS18A Gene

SNP ID Clin Chr 21 pos Sequence Context AA Info Type
rs1048002 -- 32,269,011(+) CGGGG(A/G)CAGAA utr-variant-3-prime
rs730996 -- 32,279,124(+) TGAAG(A/G)GGGCG upstream-variant-2KB
rs730997 -- 32,279,179(+) GGCCA(A/G)GCGTG upstream-variant-2KB
rs3177992 -- 32,268,232(-) TTAAA(A/C)CAAAG utr-variant-3-prime
rs2833750 -- 32,270,850(+) GCCTC(A/G)CCAGC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for MIS18A Gene

Variant ID Type Subtype PubMed ID
nsv834084 CNV Gain 17160897
nsv510795 CNV Loss 20534489

Variation tolerance for MIS18A Gene

Residual Variation Intolerance Score: 42.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.30; 25.88% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for MIS18A Gene

HapMap Linkage Disequilibrium report
MIS18A

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MIS18A Gene

Disorders for MIS18A Gene

Relevant External Links for MIS18A

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
MIS18A

No disorders were found for MIS18A Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MIS18A Gene

Publications for MIS18A Gene

  1. Priming of centromere for CENP-A recruitment by human hMis18alpha, hMis18beta, and M18BP1. (PMID: 17199038) Fujita Y. … Yanagida M. (Dev. Cell 2007) 2 3 4 67
  2. PP5644 interacts with phosphatidylinositol-4-phosphate adaptor protein-1 associated protein-1. (PMID: 15881666) Ye X.-X. … Gu J.-R. (Mol. Cell. Biochem. 2005) 3 23
  3. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  4. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T. … Vidal M. (Cell 2014) 3
  5. High-content genome-wide RNAi screens identify regulators of parkin upstream of mitophagy. (PMID: 24270810) Hasson S.A. … Youle R.J. (Nature 2013) 3

Products for MIS18A Gene

Sources for MIS18A Gene

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