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Aliases for MIS12 Gene

Aliases for MIS12 Gene

  • MIS12 Kinetochore Complex Component 2 3
  • MIS12, MIND Kinetochore Complex Component, Homolog (S. Pombe) 2
  • MIS12, MIND Kinetochore Complex Component, Homolog (Yeast) 2
  • MIS12, MIND Kinetochore Complex Component, Homolog 3
  • Homolog Of Yeast Mis12 3
  • Protein MIS12 Homolog 3
  • MIS12 Homolog 3
  • 2510025F08Rik 3
  • KNTC2AP 3
  • HMis12 3
  • MTW1 3

External Ids for MIS12 Gene

Previous GeneCards Identifiers for MIS12 Gene

  • GC17P005727
  • GC17P005334
  • GC17P005590
  • GC17P005330
  • GC17P005390
  • GC17P005280

Summaries for MIS12 Gene

GeneCards Summary for MIS12 Gene

MIS12 (MIS12 Kinetochore Complex Component) is a Protein Coding gene. Among its related pathways are Cell Cycle, Mitotic and Cell Cycle, Mitotic.

UniProtKB/Swiss-Prot for MIS12 Gene

  • Part of the MIS12 complex which is required for normal chromosome alignment and segregation and for kinetochore formation during mitosis.

Gene Wiki entry for MIS12 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MIS12 Gene

Genomics for MIS12 Gene

Regulatory Elements for MIS12 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for MIS12 Gene

Start:
5,486,285 bp from pter
End:
5,490,814 bp from pter
Size:
4,530 bases
Orientation:
Plus strand

Genomic View for MIS12 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for MIS12 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIS12 Gene

Proteins for MIS12 Gene

  • Protein details for MIS12 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9H081-MIS12_HUMAN
    Recommended name:
    Protein MIS12 homolog
    Protein Accession:
    Q9H081
    Secondary Accessions:
    • Q96N24

    Protein attributes for MIS12 Gene

    Size:
    205 amino acids
    Molecular mass:
    24140 Da
    Quaternary structure:
    • Component of the MIS12 complex composed of MIS12, DSN1, NSL1 and PMF1. Also interacts with CASC5, CBX3, CBX5, NDC80 and ZWINT.
    SequenceCaution:
    • Sequence=AK056072; Type=Frameshift; Positions=147; Evidence={ECO:0000305};

neXtProt entry for MIS12 Gene

Proteomics data for MIS12 Gene at MOPED

Post-translational modifications for MIS12 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for MIS12 Gene

No data available for DME Specific Peptides for MIS12 Gene

Domains for MIS12 Gene

Protein Domains for MIS12 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for MIS12 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9H081

UniProtKB/Swiss-Prot:

MIS12_HUMAN :
  • Q9H081
Family:
  • Belongs to the mis12 family.
genes like me logo Genes that share domains with MIS12: view

No data available for Gene Families for MIS12 Gene

Function for MIS12 Gene

Molecular function for MIS12 Gene

UniProtKB/Swiss-Prot Function: Part of the MIS12 complex which is required for normal chromosome alignment and segregation and for kinetochore formation during mitosis.

Gene Ontology (GO) - Molecular Function for MIS12 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 15371340
genes like me logo Genes that share ontologies with MIS12: view

Phenotypes for MIS12 Gene

GenomeRNAi human phenotypes for MIS12:
genes like me logo Genes that share phenotypes with MIS12: view

Animal Model Products

CRISPR Products

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for MIS12 Gene

Localization for MIS12 Gene

Subcellular locations from UniProtKB/Swiss-Prot for MIS12 Gene

Nucleus. Chromosome, centromere, kinetochore. Note=Associated with the kinetochore.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for MIS12 Gene COMPARTMENTS Subcellular localization image for MIS12 gene
Compartment Confidence
nucleus 5
cytosol 4
cytoskeleton 2

Gene Ontology (GO) - Cellular Components for MIS12 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000444 MIS12/MIND type complex IDA 16585270
GO:0000775 chromosome, centromeric region --
GO:0005634 nucleus IDA --
GO:0005829 cytosol TAS --
genes like me logo Genes that share ontologies with MIS12: view

Pathways for MIS12 Gene

genes like me logo Genes that share pathways with MIS12: view

Pathways by source for MIS12 Gene

Gene Ontology (GO) - Biological Process for MIS12 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000278 mitotic cell cycle TAS --
GO:0007049 cell cycle --
GO:0007059 chromosome segregation IMP 12515822
GO:0007067 mitotic nuclear division IEA --
GO:0007264 small GTPase mediated signal transduction TAS --
genes like me logo Genes that share ontologies with MIS12: view

Transcripts for MIS12 Gene

Unigene Clusters for MIS12 Gene

MIS12, MIND kinetochore complex component, homolog (S. pombe):
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for MIS12

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for MIS12 Gene

ExUns: 1a · 1b ^ 2a · 2b ^ 3a · 3b · 3c · 3d · 3e ^ 4a · 4b ^ 5a · 5b · 5c ^ 6a · 6b ^ 7a · 7b · 7c · 7d · 7e
SP1: - - - - - - -
SP2: - - - - - - - - - - - -
SP3: - - - - - - - - - -
SP4: - - - - - -
SP5: - - - - - - - - - - - -
SP6: - - - - - - -
SP7: - - - - -
SP8: - - - -
SP9: -

Relevant External Links for MIS12 Gene

GeneLoc Exon Structure for
MIS12
ECgene alternative splicing isoforms for
MIS12

Expression for MIS12 Gene

mRNA expression in normal human tissues for MIS12 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for MIS12 Gene

SOURCE GeneReport for Unigene cluster for MIS12 Gene Hs.267194

genes like me logo Genes that share expressions with MIS12: view

In Situ Assay Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for MIS12 Gene

Orthologs for MIS12 Gene

This gene was present in the common ancestor of chordates.

Orthologs for MIS12 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia MIS12 35
  • 99.84 (n)
  • 100 (a)
MIS12 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia MIS12 35
  • 89.27 (n)
  • 89.76 (a)
MIS12 36
  • 89 (a)
OneToOne
dog
(Canis familiaris)
Mammalia -- 36
  • 83 (a)
OneToMany
-- 36
  • 80 (a)
OneToMany
MIS12 35
  • 83.66 (n)
  • 84.31 (a)
mouse
(Mus musculus)
Mammalia Mis12 35
  • 83.58 (n)
  • 79.31 (a)
Mis12 16
Mis12 36
  • 78 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia MIS12 36
  • 58 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia MIS12 36
  • 53 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Mis12 35
  • 83.91 (n)
  • 81.77 (a)
chicken
(Gallus gallus)
Aves MIS12 35
  • 61.9 (n)
  • 60.59 (a)
MIS12 36
  • 59 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 35 (a)
OneToMany
-- 36
  • 38 (a)
OneToMany
tropical clawed frog
(Silurana tropicalis)
Amphibia mis12 35
  • 62.25 (n)
  • 55.39 (a)
zebrafish
(Danio rerio)
Actinopterygii MIS12 36
  • 34 (a)
OneToOne
zgc:64116 35
  • 50.69 (n)
  • 39.58 (a)
Species with no ortholog for MIS12:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for MIS12 Gene

ENSEMBL:
Gene Tree for MIS12 (if available)
TreeFam:
Gene Tree for MIS12 (if available)

Paralogs for MIS12 Gene

No data available for Paralogs for MIS12 Gene

Variants for MIS12 Gene

Sequence variations from dbSNP and Humsavar for MIS12 Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type MAF
rs14043 -- 5,490,283(+) TTAAG(C/T)AATTG utr-variant-3-prime
rs929261 -- 5,488,841(+) GAAAA(C/T)AACAT utr-variant-5-prime
rs1805464 -- 5,488,853(+) GCAAA(A/C)TAAGC utr-variant-5-prime
rs1805465 -- 5,489,769(+) AGTTA(C/T)ACCTT utr-variant-3-prime
rs1805466 -- 5,490,111(+) ACTGC(A/G)GAACA utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for MIS12 Gene

Variant ID Type Subtype PubMed ID
nsv1956 CNV Loss 18451855
nsv528302 CNV Loss 19592680

Relevant External Links for MIS12 Gene

HapMap Linkage Disequilibrium report
MIS12

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MIS12 Gene

Disorders for MIS12 Gene

(1) University of Copenhagen DISEASES for MIS12 Gene

genes like me logo Genes that share disorders with MIS12: view

No data available for UniProtKB/Swiss-Prot for MIS12 Gene

Publications for MIS12 Gene

  1. Towards a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs. (PMID: 11230166) Wiemann S. … Poustka A. (Genome Res. 2001) 2 3 4
  2. Human centromere chromatin protein hMis12, essential for equal segregation, is independent of CENP-A loading pathway. (PMID: 12515822) Goshima G. … Yanagida M. (J. Cell Biol. 2003) 2 3 4
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  4. A conserved Mis12 centromere complex is linked to heterochromatic HP1 and outer kinetochore protein Zwint-1. (PMID: 15502821) Obuse C. … Yanagida M. (Nat. Cell Biol. 2004) 3 4
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4

Products for MIS12 Gene

Sources for MIS12 Gene

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