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Aliases for MIRLET7I Gene

Subcategory (RNA class) for MIRLET7I Gene

miRNA

Quality Score for this RNA gene is

3

Aliases for MIRLET7I Gene

  • MicroRNA Let-7i 2 3
  • MIRNLET7I 3 6
  • LET7I 3 6
  • Hsa-Let-7i 3

External Ids for MIRLET7I Gene

ORGUL Members for MIRLET7I Gene

Previous Symbols for MIRLET7I Gene

  • MIRNLET7I

Summaries for MIRLET7I Gene

Entrez Gene Summary for MIRLET7I Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIRLET7I Gene

MIRLET7I (MicroRNA Let-7i) is a RNA Gene, and belongs to miRNA RNA class. Among its related pathways are MicroRNAs in cancer.

No data available for UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MIRLET7I Gene

Genomics for MIRLET7I Gene

Genomic Location for MIRLET7I Gene

Start:
62,603,671 bp from pter
End:
62,603,778 bp from pter
Size:
108 bases
Orientation:
Plus strand

Genomic View for MIRLET7I Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for MIRLET7I Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIRLET7I Gene

No data available for Regulatory Elements for MIRLET7I Gene

Proteins for MIRLET7I Gene

Post-translational modifications for MIRLET7I Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIRLET7I Gene

Domains for MIRLET7I Gene

Gene Families for MIRLET7I Gene

HGNC:
  • MIR :ncRNAs / Micro RNAs
genes like me logo Genes that share domains with MIRLET7I: view

No data available for Protein Domains and UniProtKB/Swiss-Prot for MIRLET7I Gene

Function for MIRLET7I Gene

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for MIRLET7I Gene

Localization for MIRLET7I Gene

No data available for Gene Ontology (GO) - Cellular Components for MIRLET7I Gene

Pathways for MIRLET7I Gene

SuperPathways for MIRLET7I Gene

Superpath Contained pathways
1 MicroRNAs in cancer
genes like me logo Genes that share pathways with MIRLET7I: view

Pathways by source for MIRLET7I Gene

1 KEGG pathway for MIRLET7I Gene

Interacting Proteins for MIRLET7I Gene

Gene Ontology (GO) - Biological Process for MIRLET7I Gene

None

Transcripts for MIRLET7I Gene

mRNA/cDNA for MIRLET7I Gene

(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Alternative Splicing Database (ASD) splice patterns (SP) for MIRLET7I Gene

No ASD Table

Relevant External Links for MIRLET7I Gene

GeneLoc Exon Structure for
MIRLET7I
ECgene alternative splicing isoforms for
MIRLET7I

Expression for MIRLET7I Gene

mRNA expression in normal human tissues for MIRLET7I Gene

genes like me logo Genes that share expressions with MIRLET7I: view

Orthologs for MIRLET7I Gene

This gene was present in the common ancestor of chordates.

Orthologs for MIRLET7I Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ptr-let-7i 37
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia bta-let-7i 37
  • 100 (a)
OneToOne
dog
(Canis familiaris)
Mammalia -- 37
  • 33 (a)
ManyToMany
mouse
(Mus musculus)
Mammalia Mirlet7i 37
  • 87 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia mdo-let-7i 37
  • 100 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 37
  • 40 (a)
ManyToMany
chicken
(Gallus gallus)
Aves gga-let-7i 37
  • 87 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia aca-let-7i 37
  • 100 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii dre-let-7i 37
  • 77 (a)
OneToOne
sea squirt
(Ciona savignyi)
Ascidiacea csa-let-7a 37
  • 44 (a)
ManyToMany
Species with no ortholog for MIRLET7I:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for MIRLET7I Gene

ENSEMBL:
Gene Tree for MIRLET7I (if available)
TreeFam:
Gene Tree for MIRLET7I (if available)

Paralogs for MIRLET7I Gene

No data available for Paralogs for MIRLET7I Gene

Variants for MIRLET7I Gene

Structural Variations from Database of Genomic Variants (DGV) for MIRLET7I Gene

Variant ID Type Subtype PubMed ID
nsv821671 CNV Loss 15273396
nsv740 CNV Insertion 18451855

Relevant External Links for MIRLET7I Gene

HapMap Linkage Disequilibrium report
MIRLET7I

No data available for Sequence variations from dbSNP and Humsavar for MIRLET7I Gene

Disorders for MIRLET7I Gene

No disorders were found for MIRLET7I Gene.

No data available for UniProtKB/Swiss-Prot for MIRLET7I Gene

Publications for MIRLET7I Gene

  1. Identification of novel genes coding for small expressed RNAs. (PMID: 11679670) Lagos-Quintana M. … Tuschl T. (Science 2001) 3
  2. Identification of tissue-specific microRNAs from mouse. (PMID: 12007417) Lagos-Quintana M. … Tuschl T. (Curr. Biol. 2002) 3
  3. miRBase: microRNA sequences, targets and gene nomenclature. (PMID: 16381832) Griffiths-Jones S. … Enright A.J. (Nucleic Acids Res. 2006) 3
  4. The tumor suppressor microRNA let-7 represses the HMGA2 oncogene. (PMID: 17437991) Lee Y.S. … Dutta A. (Genes Dev. 2007) 3
  5. A mammalian microRNA expression atlas based on small RNA library sequencing. (PMID: 17604727) Landgraf P. … Tuschl T. (Cell 2007) 3

Products for MIRLET7I Gene

  • QIAGEN qRT-PCR Assays for microRNAs that regulate MIRLET7I
    • QuantiTect SYBR Green Assays in human,mouse,rat
    • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
    • QuantiFast Probe-based Assays in human,mouse,rat
    • Predesigned siRNA for gene silencing in human,mouse,rat for MIRLET7I
    • Block miRNA regulation of MIRLET7I using miScript Target Protectors

    Sources for MIRLET7I Gene

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