Free for academic non-profit institutions. Other users need a Commercial license

Aliases for MIRLET7I Gene

Subcategory (RNA class) for MIRLET7I Gene

miRNA

Quality Score for this RNA gene is

3

Aliases for MIRLET7I Gene

  • MicroRNA Let-7i 2 3 5
  • Hsa-Let-7i 3
  • MIRNLET7I 3
  • Let-7i 3
  • LET7I 3

External Ids for MIRLET7I Gene

ORGUL Members for MIRLET7I Gene

Previous HGNC Symbols for MIRLET7I Gene

  • MIRNLET7I

Previous GeneCards Identifiers for MIRLET7I Gene

  • GC12P061286
  • GC12P062997
  • GC12P062604
  • GC12P062605

Summaries for MIRLET7I Gene

Entrez Gene Summary for MIRLET7I Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIRLET7I Gene

MIRLET7I (MicroRNA Let-7i) is an RNA Gene, and is affiliated with the miRNA class. Among its related pathways are Toll-like receptor signaling pathway and MicroRNAs in cancer.

No data available for UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MIRLET7I Gene

Genomics for MIRLET7I Gene

Regulatory Elements for MIRLET7I Gene

Enhancers for MIRLET7I Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH12F062631 1.5 FANTOM5 Ensembl ENCODE 11.1 +28.6 28550 2.2 ARID4B DMAP1 ZSCAN9 RAD21 YY1 GLIS2 EGR1 SCRT2 EGR2 TSHZ1 MIRLET7I LINC01465 USP15 GC12P062638 ENSG00000275180
GH12F062783 1.4 FANTOM5 Ensembl ENCODE 11.3 +182.7 182663 4.9 TBP TAF1 JUN SIN3A RFX5 POLR2A FOS TCF7L2 BHLHE40 CEBPB LINC01465 MIRLET7I DPY19L2 GC12M062761 LOC105369795
GH12F062793 1.1 Ensembl ENCODE 10.9 +190.4 190376 2.1 TBP CTCF PKNOX1 JUN MAX SIN3A CEBPG RAD21 RFX5 GATA3 LINC01465 MIRLET7I GC12M062761 LOC105369795
GH12F062792 0.2 Ensembl 10.9 +188.8 188815 0.2 LINC01465 MIRLET7I GC12M062761 LOC105369795
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around MIRLET7I on UCSC Golden Path with GeneCards custom track

Promoters for MIRLET7I Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000173363 214 4201 HDGF PKNOX1 CREB3L1 WRNIP1 ZFP64 ARID4B SIN3A FEZF1 DMAP1 ZNF2

Genomic Location for MIRLET7I Gene

Chromosome:
12
Start:
62,603,686 bp from pter
End:
62,603,769 bp from pter
Size:
84 bases
Orientation:
Plus strand

Genomic View for MIRLET7I Gene

Genes around MIRLET7I on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MIRLET7I Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIRLET7I Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIRLET7I Gene

Proteins for MIRLET7I Gene

Post-translational modifications for MIRLET7I Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIRLET7I Gene

Domains & Families for MIRLET7I Gene

Gene Families for MIRLET7I Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with MIRLET7I: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for MIRLET7I Gene

Function for MIRLET7I Gene

Animal Model Products

miRNA Products

Clone Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIRLET7I Gene

Localization for MIRLET7I Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS and Gene Ontology (GO) - Cellular Components for MIRLET7I Gene

Pathways & Interactions for MIRLET7I Gene

genes like me logo Genes that share pathways with MIRLET7I: view

Pathways by source for MIRLET7I Gene

1 BioSystems pathway for MIRLET7I Gene
1 KEGG pathway for MIRLET7I Gene

Interacting Proteins for MIRLET7I Gene

Gene Ontology (GO) - Biological Process for MIRLET7I Gene

None

No data available for SIGNOR curated interactions for MIRLET7I Gene

Transcripts for MIRLET7I Gene

mRNA/cDNA for MIRLET7I Gene

(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Alternative Splicing Database (ASD) splice patterns (SP) for MIRLET7I Gene

No ASD Table

Relevant External Links for MIRLET7I Gene

GeneLoc Exon Structure for
MIRLET7I
ECgene alternative splicing isoforms for
MIRLET7I

Expression for MIRLET7I Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for MIRLET7I Gene

NURSA nuclear receptor signaling pathways regulating expression of MIRLET7I Gene:

MIRLET7I
genes like me logo Genes that share expression patterns with MIRLET7I: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners and mRNA Expression by UniProt/SwissProt for MIRLET7I Gene

Orthologs for MIRLET7I Gene

This gene was present in the common ancestor of chordates.

Orthologs for MIRLET7I Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia bta-let-7i 35
  • 100 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia mdo-let-7i 35
  • 100 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia ptr-let-7i 35
  • 100 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Mirlet7i 35
  • 87 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 35
  • 40 (a)
ManyToMany
dog
(Canis familiaris)
Mammalia -- 35
  • 33 (a)
ManyToMany
chicken
(Gallus gallus)
Aves gga-let-7i 35
  • 87 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia aca-let-7i 35
  • 100 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii dre-let-7i 35
  • 77 (a)
OneToOne
sea squirt
(Ciona savignyi)
Ascidiacea csa-let-7a 35
  • 44 (a)
ManyToMany
Species where no ortholog for MIRLET7I was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for MIRLET7I Gene

ENSEMBL:
Gene Tree for MIRLET7I (if available)
TreeFam:
Gene Tree for MIRLET7I (if available)

Paralogs for MIRLET7I Gene

No data available for Paralogs for MIRLET7I Gene

Variants for MIRLET7I Gene

Sequence variations from dbSNP and Humsavar for MIRLET7I Gene

SNP ID Clin Chr 12 pos Sequence Context AA Info Type
rs10877885 -- 62,602,204(+) CAAGC(C/T)CTAAC nc-transcript-variant, upstream-variant-2KB
rs10877886 -- 62,602,281(+) CGTAA(A/G)TTGTC nc-transcript-variant, upstream-variant-2KB
rs10877887 -- 62,603,400(+) CTCTC(C/T)CCGCA nc-transcript-variant, upstream-variant-2KB
rs112991697 -- 62,603,234(+) GCTCG(C/G)GACGT nc-transcript-variant, upstream-variant-2KB
rs113188524 -- 62,603,373(+) GCTCC(A/C/G/T)CTCGG nc-transcript-variant, upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for MIRLET7I Gene

Variant ID Type Subtype PubMed ID
nsv821671 CNV loss 15273396
nsv740 CNV insertion 18451855

Relevant External Links for MIRLET7I Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MIRLET7I

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Variation tolerance for MIRLET7I Gene

Disorders for MIRLET7I Gene

Relevant External Links for MIRLET7I

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
MIRLET7I

No disorders were found for MIRLET7I Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MIRLET7I Gene

Publications for MIRLET7I Gene

  1. BAG3-mediated miRNA let-7g and let-7i inhibit proliferation and enhance apoptosis of human esophageal carcinoma cells by targeting the drug transporter ABCC10. (PMID: 26655271) Wu K. … Zhao S. (Cancer Lett. 2016) 3 64
  2. A mutant p53/let-7i-axis-regulated gene network drives cell migration, invasion and metastasis. (PMID: 24662829) Subramanian M. … Lal A. (Oncogene 2015) 3 64
  3. A novel serum microRNA panel to discriminate benign from malignant ovarian disease. (PMID: 25451316) Langhe R. … O'Toole S. (Cancer Lett. 2015) 3 64
  4. MicroRNAs let-7b/i suppress human glioma cell invasion and migration by targeting IKBKE directly. (PMID: 25656572) Tian Y. … Zhong Y. (Biochem. Biophys. Res. Commun. 2015) 3 64
  5. Let-7i inhibits the malignant phenotype of osteosarcoma cells by targeting Aurora-B. (PMID: 25997616) Zhang G.M. … Liu Z.L. (Mol Med Rep 2015) 3 64

Products for MIRLET7I Gene

Sources for MIRLET7I Gene

Content
Loading form....