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Aliases for MIRLET7G Gene

Subcategory (RNA class) for MIRLET7G Gene

miRNA

Quality Score for this RNA gene is

10.2

Aliases for MIRLET7G Gene

  • MicroRNA Let-7g 2 3 5
  • Hsa-Let-7g 3
  • MIRNLET7G 3
  • Let-7g 3
  • LET7G 3

External Ids for MIRLET7G Gene

Previous HGNC Symbols for MIRLET7G Gene

  • MIRNLET7G

Previous GeneCards Identifiers for MIRLET7G Gene

  • GC03M052280
  • GC03M052302

Summaries for MIRLET7G Gene

Entrez Gene Summary for MIRLET7G Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIRLET7G Gene

MIRLET7G (MicroRNA Let-7g) is an RNA Gene, and is affiliated with the miRNA class. Among its related pathways are MicroRNAs in cancer and Metastatic brain tumor.

fRNAdb sequence ontologies for MIRLET7G Gene - the ORGUL cluster for this gene includes several descriptions:

  • pre_miRNA: The 60-70 nucleotide region remain after Drosha processing of the primary transcript, that folds back upon itself to form a hairpin sructure.

  • nc_conserved_region: Non-coding region of sequence similarity by descent from a common ancestor.

View fRNAdb secondary structures for MIRLET7G

Additional gene information for MIRLET7G Gene

No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary and piRNA Summary for MIRLET7G Gene

Genomics for MIRLET7G Gene

Regulatory Elements for MIRLET7G Gene

Enhancers for MIRLET7G Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH03H052269 1 Ensembl ENCODE dbSUPER 0.7 -3.2 -3196 4.9 ZNF121 KLF1 ZBTB33 PRDM10 PRDM1 ITIH4 GLYCTK PPM1M MUSTN1 GC03M052275 MIRLET7G
GH03H052265 0.8 ENCODE dbSUPER 0.7 +2.8 2802 0.2 CTBP1 MNT ZBTB33 DPF2 NR2F2 TWF2 MIRLET7G PIR44903
GH03H052264 0.4 dbSUPER 0.7 +3.4 3409 0.5 NR2F2 PPM1M MIRLET7G PIR44903
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around MIRLET7G on UCSC Golden Path with GeneCards custom track

Genomic Locations for MIRLET7G Gene

Genomic Locations for MIRLET7G Gene
chr3:52,268,278-52,268,361
(GRCh38/hg38)
Size:
84 bases
Orientation:
Minus strand
chr3:52,302,292-52,302,379
(GRCh37/hg19)

Genomic View for MIRLET7G Gene

Genes around MIRLET7G on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MIRLET7G Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIRLET7G Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIRLET7G Gene

ORGUL Member Location for MIRLET7G Gene

ORGUL Member Location for MIRLET7G gene

Proteins for MIRLET7G Gene

Post-translational modifications for MIRLET7G Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIRLET7G Gene

Domains & Families for MIRLET7G Gene

Gene Families for MIRLET7G Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with MIRLET7G: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for MIRLET7G Gene

Function for MIRLET7G Gene

Animal Model Products

miRNA Products

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIRLET7G Gene

Localization for MIRLET7G Gene

Gene Ontology (GO) - Cellular Components for MIRLET7G Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005615 extracellular space IDA 26646931
GO:0005623 cell IEA --
genes like me logo Genes that share ontologies with MIRLET7G: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS and Subcellular locations from the Human Protein Atlas (HPA) for MIRLET7G Gene

Pathways & Interactions for MIRLET7G Gene

genes like me logo Genes that share pathways with MIRLET7G: view

Pathways by source for MIRLET7G Gene

2 BioSystems pathways for MIRLET7G Gene
1 KEGG pathway for MIRLET7G Gene

Interacting Proteins for MIRLET7G Gene

Gene Ontology (GO) - Biological Process for MIRLET7G Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0071333 cellular response to glucose stimulus ISS --
genes like me logo Genes that share ontologies with MIRLET7G: view

No data available for SIGNOR curated interactions for MIRLET7G Gene

Drugs & Compounds for MIRLET7G Gene

No Compound Related Data Available

Transcripts for MIRLET7G Gene

fRNAdb Secondary structures for MIRLET7G Gene

  • FR046598

mRNA/cDNA for MIRLET7G Gene

(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

miRNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for MIRLET7G Gene

No ASD Table

Relevant External Links for MIRLET7G Gene

GeneLoc Exon Structure for
MIRLET7G
ECgene alternative splicing isoforms for
MIRLET7G

Expression for MIRLET7G Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for MIRLET7G Gene

NURSA nuclear receptor signaling pathways regulating expression of MIRLET7G Gene:

MIRLET7G
genes like me logo Genes that share expression patterns with MIRLET7G: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for MIRLET7G Gene

Orthologs for MIRLET7G Gene

This gene was present in the common ancestor of chordates.

Orthologs for MIRLET7G Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia bta-let-7g 34
  • 100 (a)
OneToOne
dog
(Canis familiaris)
Mammalia cfa-let-7g 34
  • 100 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia mdo-let-7g 34
  • 100 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Mirlet7g 34
  • 100 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia ptr-let-7g 34
  • 100 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia oan-let-7g 34
  • 88 (a)
OneToOne
chicken
(Gallus gallus)
Aves gga-let-7g 34
  • 95 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia aca-let-7g 34
  • 96 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii dre-let-7j 34
  • 72 (a)
OneToOne
sea squirt
(Ciona savignyi)
Ascidiacea csa-let-7d 34
  • 42 (a)
ManyToMany
Species where no ortholog for MIRLET7G was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for MIRLET7G Gene

ENSEMBL:
Gene Tree for MIRLET7G (if available)
TreeFam:
Gene Tree for MIRLET7G (if available)

Paralogs for MIRLET7G Gene

No data available for Paralogs for MIRLET7G Gene

Variants for MIRLET7G Gene

Sequence variations from dbSNP and Humsavar for MIRLET7G Gene

SNP ID Clin Chr 03 pos Sequence Context AA Info Type
rs1000388354 -- 52,268,659(+) TGAAA(C/T)ACAGG intron-variant, upstream-variant-2KB
rs1001687191 -- 52,269,707(+) CCTAG(G/T)CAACA intron-variant, upstream-variant-2KB
rs1002563543 -- 52,268,906(+) ACCTC(C/T)AGGGC intron-variant, upstream-variant-2KB
rs1002926130 -- 52,269,158(+) CATCA(A/C)TAATC intron-variant, upstream-variant-2KB
rs1003624331 -- 52,269,925(+) ACTCT(A/G)CTCTT intron-variant, upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for MIRLET7G Gene

Variant ID Type Subtype PubMed ID
nsv834695 CNV loss 17160897
nsv834694 CNV gain 17160897
nsv822090 CNV gain 20364138
nsv519445 CNV gain+loss 19592680
nsv470572 CNV loss 18288195

Relevant External Links for MIRLET7G Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MIRLET7G

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Variation tolerance for MIRLET7G Gene

Disorders for MIRLET7G Gene

Relevant External Links for MIRLET7G

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
MIRLET7G

No disorders were found for MIRLET7G Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MIRLET7G Gene

Publications for MIRLET7G Gene

  1. Identification of tissue-specific microRNAs from mouse. (PMID: 12007417) Lagos-Quintana M … Tuschl T (Current biology : CB 2002) 1 3 60
  2. Association of MicroRNAs and YRNAs With Platelet Function. (PMID: 26646931) Kaudewitz D … Mayr M (Circulation research 2016) 3 60
  3. Let-7g-5p inhibits epithelial-mesenchymal transition consistent with reduction of glioma stem cell phenotypes by targeting VSIG4 in glioblastoma. (PMID: 27634309) Zhang XH … Xie YJ (Oncology reports 2016) 3 60
  4. Mutual antagonism between hepatitis B viral mRNA and host microRNA let-7. (PMID: 26979389) Takata A … Koike K (Scientific reports 2016) 3 60
  5. BAG3-mediated miRNA let-7g and let-7i inhibit proliferation and enhance apoptosis of human esophageal carcinoma cells by targeting the drug transporter ABCC10. (PMID: 26655271) Wu K … Zhao S (Cancer letters 2016) 3 60

Products for MIRLET7G Gene

Sources for MIRLET7G Gene

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