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Aliases for MIRLET7G Gene

Subcategory (RNA class) for MIRLET7G Gene

miRNA

Quality Score for this RNA gene is

10.2

Aliases for MIRLET7G Gene

  • MicroRNA Let-7g 2 3
  • MIRNLET7G 3 6
  • LET7G 3 6
  • Hsa-Let-7g 3

External Ids for MIRLET7G Gene

Previous Symbols for MIRLET7G Gene

  • MIRNLET7G

Summaries for MIRLET7G Gene

Entrez Gene Summary for MIRLET7G Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIRLET7G Gene

MIRLET7G (MicroRNA Let-7g) is a RNA Gene, and belongs to miRNA RNA class. Among its related pathways are MicroRNAs in cancer.

fRNAdb sequence ontologies for MIRLET7G Gene - the ORGUL cluster for this gene includes several descriptions:

  • pre_miRNA: The 60-70 nucleotide region remain after Drosha processing of the primary transcript, that folds back upon itself to form a hairpin sructure.

  • nc_conserved_region: Non-coding region of sequence similarity by descent from a common ancestor.

View fRNAdb secondary structures for MIRLET7G

No data available for UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary and piRNA Summary for MIRLET7G Gene

Genomics for MIRLET7G Gene

Genomic Location for MIRLET7G Gene

Start:
52,268,267 bp from pter
End:
52,268,377 bp from pter
Size:
111 bases
Orientation:
Minus strand

Genomic View for MIRLET7G Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for MIRLET7G Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIRLET7G Gene

ORGUL Member Location for MIRLET7G Gene

ORGUL Member Location for MIRLET7G gene

No data available for Regulatory Elements for MIRLET7G Gene

Proteins for MIRLET7G Gene

Post-translational modifications for MIRLET7G Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIRLET7G Gene

Domains for MIRLET7G Gene

Gene Families for MIRLET7G Gene

HGNC:
  • MIR :ncRNAs / Micro RNAs
genes like me logo Genes that share domains with MIRLET7G: view

No data available for Protein Domains and UniProtKB/Swiss-Prot for MIRLET7G Gene

Function for MIRLET7G Gene

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for MIRLET7G Gene

Localization for MIRLET7G Gene

No data available for Gene Ontology (GO) - Cellular Components for MIRLET7G Gene

Pathways for MIRLET7G Gene

SuperPathways for MIRLET7G Gene

Superpath Contained pathways
1 MicroRNAs in cancer
genes like me logo Genes that share pathways with MIRLET7G: view

Pathways by source for MIRLET7G Gene

1 KEGG pathway for MIRLET7G Gene

Interacting Proteins for MIRLET7G Gene

Gene Ontology (GO) - Biological Process for MIRLET7G Gene

None

Transcripts for MIRLET7G Gene

fRNAdb Secondary structures for MIRLET7G Gene

  • hsa-let-7g_MI0000433_Homo_sapiens_let-7g_stem-loop_hairpin
  • FR342776

mRNA/cDNA for MIRLET7G Gene

(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Alternative Splicing Database (ASD) splice patterns (SP) for MIRLET7G Gene

No ASD Table

Relevant External Links for MIRLET7G Gene

GeneLoc Exon Structure for
MIRLET7G
ECgene alternative splicing isoforms for
MIRLET7G

Expression for MIRLET7G Gene

mRNA expression in normal human tissues for MIRLET7G Gene

genes like me logo Genes that share expressions with MIRLET7G: view

Orthologs for MIRLET7G Gene

This gene was present in the common ancestor of chordates.

Orthologs for MIRLET7G Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ptr-let-7g 37
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia bta-let-7g 37
  • 100 (a)
OneToOne
dog
(Canis familiaris)
Mammalia cfa-let-7g 37
  • 100 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Mirlet7g 37
  • 100 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia mdo-let-7g 37
  • 100 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia oan-let-7g 37
  • 88 (a)
OneToOne
chicken
(Gallus gallus)
Aves gga-let-7g 37
  • 95 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia aca-let-7g 37
  • 96 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii dre-let-7j 37
  • 72 (a)
OneToOne
sea squirt
(Ciona savignyi)
Ascidiacea csa-let-7d 37
  • 42 (a)
ManyToMany
Species with no ortholog for MIRLET7G:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for MIRLET7G Gene

ENSEMBL:
Gene Tree for MIRLET7G (if available)
TreeFam:
Gene Tree for MIRLET7G (if available)

Paralogs for MIRLET7G Gene

No data available for Paralogs for MIRLET7G Gene

Variants for MIRLET7G Gene

Structural Variations from Database of Genomic Variants (DGV) for MIRLET7G Gene

Variant ID Type Subtype PubMed ID
nsv519445 CNV Gain+Loss 19592680
nsv470572 CNV Loss 18288195
nsv834694 CNV Gain 17160897
nsv834695 CNV Loss 17160897
dgv5136n71 CNV Gain 21882294
nsv876789 CNV Loss 21882294
nsv822090 CNV Gain 20364138

Relevant External Links for MIRLET7G Gene

HapMap Linkage Disequilibrium report
MIRLET7G

No data available for Sequence variations from dbSNP and Humsavar for MIRLET7G Gene

Disorders for MIRLET7G Gene

No disorders were found for MIRLET7G Gene.

No data available for UniProtKB/Swiss-Prot for MIRLET7G Gene

Publications for MIRLET7G Gene

  1. Identification of tissue-specific microRNAs from mouse. (PMID: 12007417) Lagos-Quintana M. … Tuschl T. (Curr. Biol. 2002) 3
  2. miRBase: microRNA sequences, targets and gene nomenclature. (PMID: 16381832) Griffiths-Jones S. … Enright A.J. (Nucleic Acids Res. 2006) 3
  3. A mammalian microRNA expression atlas based on small RNA library sequencing. (PMID: 17604727) Landgraf P. … Tuschl T. (Cell 2007) 3
  4. Patterns of known and novel small RNAs in human cervical cancer. (PMID: 17616659) Lui W.O. … Fire A. (Cancer Res. 2007) 3
  5. Determinants of microRNA processing inhibition by the developmentally regulated RNA-binding protein Lin28. (PMID: 18550544) Piskounova E. … Gregory R.I. (J. Biol. Chem. 2008) 3

Products for MIRLET7G Gene

Sources for MIRLET7G Gene

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