MIRLET7G Gene
RNA gene GIFtS: 21
GCID: GC03M052302
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microRNA let-7g
(Previous symbol: MIRNLET7G)
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Aliases
for MIRLET7G gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
Subcategory (RNA class): miRNA
Quality score for this RNA gene is 13
| Aliases |
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| MicroRNA Let-7g1 2 | | MIRNLET7G1 2 5 | | Hsa-Let-7g1 | | LET7G2 5 | | Let-7g1 |
| External Ids: | HGNC: 314851 | Entrez Gene: 4068902 | Ensembl: ENSG000001991507 | OMIM: 6121025 |
Export aliases for MIRLET7G gene to outside databasesPrevious GC identifer: GC03M052280
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Summaries
for MIRLET7G gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for MIRLET7G:
microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of geneexpression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribedby RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be eitherprotein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce anapproximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicerribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporatedinto a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with themiRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeqrepresents the predicted microRNA stem-loop. (provided by RefSeq, Sep 2009)
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Genomic Views
for MIRLET7G gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| Regulatory elements:
 Search SABiosciences Regulatory transcription factor binding sites for MIRLET7G
Other transcription factors
Search SABiosciences Chromatin IP Primers for MIRLET7G
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat MIRLET7G |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 3p21.1 Ensembl cytogenetic band: 3p21.1 HGNC cytogenetic band: 3p21.1MIRLET7G Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 3 GeneLoc Exon Structure GeneLoc location for GC03M052302: view genomic region (via miRBase)
(about GC identifiers)
Start:
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52,302,292 bp from pter |
End:
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52,302,379 bp from pter |
Size:
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88 bases |
Orientation:
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minus strand |
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Proteins
for MIRLET7G gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
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UniProtKB: --
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Protein
Domains /
Families
for MIRLET7G gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
| -- |
Function
for MIRLET7G gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
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Pathways & Interactions
for MIRLET7G gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
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Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for MIRLET7G
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Drugs & Compounds
for MIRLET7G gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
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 Browse Tocris compounds for MIRLET7G
Search CenterWatch for drugs/clinical trials and news about MIRLET7G 
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Transcripts
for MIRLET7G gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
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1 Ensembl transcript including schematic representation, and UCSC links where relevant: ENST00000362280(miRNA)
GeneLoc Exon Structure
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Expression
for MIRLET7G gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| Expression evidence for MIRLET7G:none
MIRLET7G expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: --
About this image SABiosciences Custom PCR Arrays for MIRLET7G
Primer
Products: |  | Browse OriGene genome-wide validated SYBR primer pairs
Browse OriGene validated miRNA SYBR primer pairs
| | | Search SABiosciences RT2 qPCR
Primer Assays in human, mouse, rat MIRLET7G | | | Search QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat MIRLET7G | | | Search QIAGEN QuantiFast Probe-based Assays in human, mouse, rat MIRLET7G |
Orthologs
for MIRLET7G gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
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ENSEMBL Gene Tree for MIRLET7G (if available)
TreeFam Gene Tree for MIRLET7G (if available) |
Paralogs
for MIRLET7G gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for MIRLET7G gene
- MIRLET7B2 MIRLET7C2 MIRLET7I2 MIRLET7A22 MIRLET7F22 MIRLET7D2 MIR982 MIRLET7F12
- MIRLET7A12 MIRLET7A32 MIRLET7E2
MIRLET7G for paralogs About GeneDecksing
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Genomic Variants
for MIRLET7G gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
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Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 2 variations for MIRLET7G
2 CNVs: 51113 4337 | SABiosciences Cancer Mutation PCR Assays |
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Disorders
/ Diseases
for MIRLET7G gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
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MIRLET7G for disorders About GeneDecksing
OMIM gene information: 612102
OMIM disorders: --
4  diseases for MIRLET7G: About MalaCardscervical cancer cervicitis pancreatitis hepatitis
Export disorders for MIRLET7G gene to outside databases
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Publications
for MIRLET7G gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
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PubMed articles for MIRLET7G gene, integrated from 9 sources (see all 19):
(articles sorted by number of sources associating them with MIRLET7G) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Structural basis of pre-let-7 miRNA recognition by the zinc knuckles of pluripotency factor Lin28. (PubMed id 22157959)1 Loughlin F.E....Allain F.H. (2012)
- Accumulation of pre-let-7g and downregulation of matur e let-7g with the depletion of EWS. (PubMed id 22910415)1 Sohn E.J....Wu Y.P. (2012)
- An anti-let-7 sponge decoys and decays endogenous let- 7 functions. (PubMed id 22871741)1 Yang X....Yang B.B. (2012)
- MicroRNA hsa-let-7g targets lectin-like oxidized low-d ensity lipoprotein receptor-1 expression and inhibits apoptosis in human smooth muscle cells. (PubMed id 22956623)1 Ding Z....Mehta J.L. (2012)
- Recognition of the let-7g miRNA precursor by human Lin 28B. (PubMed id 23063642)1 Ali P.S....Filipek S. (2012)
- Let-7 modulates acquired resistance of ovarian cancer to Taxanes via IMP-1-mediated stabilization of multidrug resistance 1. (PubMed id 21618519)1 Boyerinas B....Peter M.E. (2012)
- Circulating microRNA profiles reflect the presence of breast tumours but not the profiles of microRNAs within the tumours. (PubMed id 22821209)1 Cookson V.J....Hughes T.A. (2012)
- miR-9 and let-7g enhance the sensitivity to ionizing radiation by suppression of NFI_B1. (PubMed id 21464588)1 Arora H....Park W.Y. (2011)
- Negative feedback regulation between microRNA let-7g a nd the oxLDL receptor LOX-1. (PubMed id 22135361)1 Chen K.C....Juo S.H. (2011)
- Hsa-let-7g inhibits proliferation of hepatocellular c arcinoma cells by downregulation of c-Myc and upregulation of p16(INK4A). (PubMed id 20309945)1 Lan F.F....Kung H.F. (2011)
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External Searches for MIRLET7G gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
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Genome Databases showing MIRLET7G gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
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Other Databases showing MIRLET7G gene
(According to HUGE)
About This Section
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Specialized Databases showing MIRLET7G gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
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| Name | Description |
| PharmGKB entry for MIRLET7G | Pharmacogenomics, SNPs, Pathways |
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About This Section
| Patent Information for MIRLET7G gene:
Search GeneIP for patents involving MIRLET7G
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
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Products
for MIRLET7G gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
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|  | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat MIRLET7G | | | Search QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing MIRLET7G | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat MIRLET7G | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat MIRLET7G | | | Search QIAGEN QuantiFast Probe-based Assays in human, mouse, rat MIRLET7G | | | Search QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat MIRLET7G |
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 | | | | |  |  |  | | | | Search ThermoFisher Antibodies for MIRLET7G |
| | | Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat MIRLET7G |
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Last full update: 19 Mar 2013 -
Incrementals: 21 Mar 2013 , 15 Apr 2013 , 26 Apr 2013
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