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Aliases for MIRLET7G Gene

Subcategory (RNA class) for MIRLET7G Gene


Quality Score for this RNA gene is


Aliases for MIRLET7G Gene

  • MicroRNA Let-7g 2 3 5
  • Hsa-Let-7g 3
  • Let-7g 3
  • LET7G 3

External Ids for MIRLET7G Gene

Previous HGNC Symbols for MIRLET7G Gene


Previous GeneCards Identifiers for MIRLET7G Gene

  • GC03M052280
  • GC03M052302

Summaries for MIRLET7G Gene

Entrez Gene Summary for MIRLET7G Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIRLET7G Gene

MIRLET7G (MicroRNA Let-7g) is an RNA Gene, and is affiliated with the miRNA class. Among its related pathways are Parkinsons Disease Pathway and MicroRNAs in cancer.

fRNAdb sequence ontologies for MIRLET7G Gene - the ORGUL cluster for this gene includes several descriptions:

  • pre_miRNA: The 60-70 nucleotide region remain after Drosha processing of the primary transcript, that folds back upon itself to form a hairpin sructure.

  • nc_conserved_region: Non-coding region of sequence similarity by descent from a common ancestor.

View fRNAdb secondary structures for MIRLET7G

No data available for UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary and piRNA Summary for MIRLET7G Gene

Genomics for MIRLET7G Gene

Regulatory Elements for MIRLET7G Gene

Enhancers for MIRLET7G Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH03F052269 0.7 Ensembl ENCODE 0.8 -3.2 -3196 4.9 WRNIP1 ARID4B DMAP1 ZNF48 ZNF121 SLC30A9 SP5 KAT8 NFIL3 MIER3 ITIH4 GLYCTK PPM1M MUSTN1 GC03M052275 MIRLET7G
GH03F052265 0.6 ENCODE 0.8 +2.8 2802 0.2 CTCF ZBTB33 TWF2 MIRLET7G PIR44903
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around MIRLET7G on UCSC Golden Path with GeneCards custom track

Genomic Location for MIRLET7G Gene

52,268,278 bp from pter
52,268,361 bp from pter
84 bases
Minus strand

Genomic View for MIRLET7G Gene

Genes around MIRLET7G on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MIRLET7G Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIRLET7G Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIRLET7G Gene

ORGUL Member Location for MIRLET7G Gene

ORGUL Member Location for MIRLET7G gene

Proteins for MIRLET7G Gene

Post-translational modifications for MIRLET7G Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIRLET7G Gene

Domains & Families for MIRLET7G Gene

Gene Families for MIRLET7G Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with MIRLET7G: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for MIRLET7G Gene

Function for MIRLET7G Gene

Animal Model Products

miRNA Products

Clone Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIRLET7G Gene

Localization for MIRLET7G Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS and Gene Ontology (GO) - Cellular Components for MIRLET7G Gene

Pathways & Interactions for MIRLET7G Gene

genes like me logo Genes that share pathways with MIRLET7G: view

Pathways by source for MIRLET7G Gene

1 BioSystems pathway for MIRLET7G Gene
1 KEGG pathway for MIRLET7G Gene

Interacting Proteins for MIRLET7G Gene

Gene Ontology (GO) - Biological Process for MIRLET7G Gene


No data available for SIGNOR curated interactions for MIRLET7G Gene

Transcripts for MIRLET7G Gene

fRNAdb Secondary structures for MIRLET7G Gene

  • FR046598


(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Alternative Splicing Database (ASD) splice patterns (SP) for MIRLET7G Gene

No ASD Table

Relevant External Links for MIRLET7G Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for MIRLET7G Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for MIRLET7G Gene

NURSA nuclear receptor signaling pathways regulating expression of MIRLET7G Gene:

genes like me logo Genes that share expression patterns with MIRLET7G: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners and mRNA Expression by UniProt/SwissProt for MIRLET7G Gene

Orthologs for MIRLET7G Gene

This gene was present in the common ancestor of chordates.

Orthologs for MIRLET7G Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia bta-let-7g 35
  • 100 (a)
(Canis familiaris)
Mammalia cfa-let-7g 35
  • 100 (a)
(Monodelphis domestica)
Mammalia mdo-let-7g 35
  • 100 (a)
(Mus musculus)
Mammalia Mirlet7g 35
  • 100 (a)
(Pan troglodytes)
Mammalia ptr-let-7g 35
  • 100 (a)
(Ornithorhynchus anatinus)
Mammalia oan-let-7g 35
  • 88 (a)
(Gallus gallus)
Aves gga-let-7g 35
  • 95 (a)
(Anolis carolinensis)
Reptilia aca-let-7g 35
  • 96 (a)
(Danio rerio)
Actinopterygii dre-let-7j 35
  • 72 (a)
sea squirt
(Ciona savignyi)
Ascidiacea csa-let-7d 35
  • 42 (a)
Species where no ortholog for MIRLET7G was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for MIRLET7G Gene

Gene Tree for MIRLET7G (if available)
Gene Tree for MIRLET7G (if available)

Paralogs for MIRLET7G Gene

No data available for Paralogs for MIRLET7G Gene

Variants for MIRLET7G Gene

Sequence variations from dbSNP and Humsavar for MIRLET7G Gene

SNP ID Clin Chr 03 pos Sequence Context AA Info Type
rs11714358 -- 52,269,584(+) aatta(C/G)ccagg intron-variant, upstream-variant-2KB
rs12171285 -- 52,268,245(+) ATCCT(C/T)TCAGC intron-variant, downstream-variant-500B
rs138557188 -- 52,270,320(+) TCACC(A/G)TATCG intron-variant, upstream-variant-2KB
rs141646777 -- 52,270,018(+) TAGTT(C/G)AAGCA intron-variant, upstream-variant-2KB
rs145909524 -- 52,268,270(+) GGCGC(A/G)CTGTT intron-variant, downstream-variant-500B

Structural Variations from Database of Genomic Variants (DGV) for MIRLET7G Gene

Variant ID Type Subtype PubMed ID
nsv470572 CNV loss 18288195
nsv519445 CNV gain+loss 19592680
nsv822090 CNV gain 20364138
nsv834694 CNV gain 17160897
nsv834695 CNV loss 17160897

Relevant External Links for MIRLET7G Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Variation tolerance for MIRLET7G Gene

Disorders for MIRLET7G Gene

Relevant External Links for MIRLET7G

Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for MIRLET7G Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MIRLET7G Gene

Publications for MIRLET7G Gene

  1. Identification of tissue-specific microRNAs from mouse. (PMID: 12007417) Lagos-Quintana M. … Tuschl T. (Curr. Biol. 2002) 1 3 64
  2. MicroRNA let-7g cooperates with interferon/ribavirin to repress hepatitis C virus replication. (PMID: 26489607) Chou W.W. … Dai C.Y. (J. Mol. Med. 2016) 3 64
  3. BAG3-mediated miRNA let-7g and let-7i inhibit proliferation and enhance apoptosis of human esophageal carcinoma cells by targeting the drug transporter ABCC10. (PMID: 26655271) Wu K. … Zhao S. (Cancer Lett. 2016) 3 64
  4. Hsa-let-7g miRNA regulates the anti-tumor effects of gastric cancer cells under oxidative stress through the expression of DDR genes. (PMID: 25972194) Hu H. … Hou M. (J Toxicol Sci 2015) 3 64
  5. A variant in 3'-untranslated region of KRAS compromises its interaction with hsa-let-7g and contributes to the development of lung cancer in patients with COPD. (PMID: 26316738) Hu H. … Chen Y. (Int J Chron Obstruct Pulmon Dis 2015) 3 64

Products for MIRLET7G Gene

Sources for MIRLET7G Gene

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