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Aliases for MIRLET7F2 Gene

Subcategory (RNA class) for MIRLET7F2 Gene

miRNA

Quality Score for this RNA gene is

3

Aliases for MIRLET7F2 Gene

  • MicroRNA Let-7f-2 2 3 5
  • Hsa-Let-7f-2 3
  • MIRNLET7F2 3
  • Let-7f-2 3
  • LET7F2 3

External Ids for MIRLET7F2 Gene

Previous HGNC Symbols for MIRLET7F2 Gene

  • MIRNLET7F2

Summaries for MIRLET7F2 Gene

Entrez Gene Summary for MIRLET7F2 Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIRLET7F2 Gene

MIRLET7F2 (MicroRNA Let-7f-2) is an RNA Gene, and is affiliated with the miRNA class. Among its related pathways are MicroRNAs in cancer and Metastatic brain tumor.

Additional gene information for MIRLET7F2 Gene

No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MIRLET7F2 Gene

Genomics for MIRLET7F2 Gene

Regulatory Elements for MIRLET7F2 Gene

Enhancers for MIRLET7F2 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH0XH053681 1.1 ENCODE 0.1 -127.1 -127098 5 HDGF PKNOX1 MLX ARNT ARID4B SIN3A DMAP1 ZNF2 YY1 ZNF207 FAM156B PHF8 KANTR HUWE1 ACTG1P10 ENSG00000233250 TSPYL2 KDM5C FGD1 HSD17B10
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around MIRLET7F2 on UCSC Golden Path with GeneCards custom track

Genomic Location for MIRLET7F2 Gene

Chromosome:
X
Start:
53,557,192 bp from pter
End:
53,557,274 bp from pter
Size:
83 bases
Orientation:
Minus strand

Genomic View for MIRLET7F2 Gene

Genes around MIRLET7F2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MIRLET7F2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIRLET7F2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIRLET7F2 Gene

Proteins for MIRLET7F2 Gene

Post-translational modifications for MIRLET7F2 Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIRLET7F2 Gene

Domains & Families for MIRLET7F2 Gene

Gene Families for MIRLET7F2 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with MIRLET7F2: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for MIRLET7F2 Gene

Function for MIRLET7F2 Gene

Gene Ontology (GO) - Molecular Function for MIRLET7F2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:1903231 mRNA binding involved in posttranscriptional gene silencing IDA 21962509
genes like me logo Genes that share ontologies with MIRLET7F2: view

Animal Model Products

CRISPR Products

miRNA Products

Clone Products

  • Applied Biological Materials Clones for MIRLET7F2
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIRLET7F2 Gene

Localization for MIRLET7F2 Gene

Gene Ontology (GO) - Cellular Components for MIRLET7F2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005615 extracellular space IDA 26646931
genes like me logo Genes that share ontologies with MIRLET7F2: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS and Subcellular locations from the Human Protein Atlas (HPA) for MIRLET7F2 Gene

Pathways & Interactions for MIRLET7F2 Gene

genes like me logo Genes that share pathways with MIRLET7F2: view

Pathways by source for MIRLET7F2 Gene

1 BioSystems pathway for MIRLET7F2 Gene
1 KEGG pathway for MIRLET7F2 Gene

Interacting Proteins for MIRLET7F2 Gene

Gene Ontology (GO) - Biological Process for MIRLET7F2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0032007 negative regulation of TOR signaling IDA 21962509
GO:0035195 gene silencing by miRNA IDA 21962509
GO:0051898 negative regulation of protein kinase B signaling IDA 21962509
genes like me logo Genes that share ontologies with MIRLET7F2: view

No data available for SIGNOR curated interactions for MIRLET7F2 Gene

Drugs & Compounds for MIRLET7F2 Gene

No Compound Related Data Available

Transcripts for MIRLET7F2 Gene

mRNA/cDNA for MIRLET7F2 Gene

(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

CRISPR Products

miRNA Products

Clone Products

  • Applied Biological Materials Clones for MIRLET7F2
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

Alternative Splicing Database (ASD) splice patterns (SP) for MIRLET7F2 Gene

No ASD Table

Relevant External Links for MIRLET7F2 Gene

GeneLoc Exon Structure for
MIRLET7F2
ECgene alternative splicing isoforms for
MIRLET7F2

Expression for MIRLET7F2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for MIRLET7F2 Gene

NURSA nuclear receptor signaling pathways regulating expression of MIRLET7F2 Gene:

MIRLET7F2
genes like me logo Genes that share expression patterns with MIRLET7F2: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for MIRLET7F2 Gene

Orthologs for MIRLET7F2 Gene

This gene was present in the common ancestor of chordates.

Orthologs for MIRLET7F2 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia bta-let-7f-2 34
  • 100 (a)
OneToOne
dog
(Canis familiaris)
Mammalia -- 34
  • 100 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Mirlet7f-2 34
  • 100 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia ptr-let-7f-2 34
  • 100 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia mdo-let-7f-2 34
  • 94 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia oan-let-7f-2 34
  • 59 (a)
OneToOne
chicken
(Gallus gallus)
Aves gga-let-7a-1 34
  • 83 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia aca-let-7f-1 34
  • 78 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii dre-let-7a-1 34
  • 76 (a)
OneToOne
Species where no ortholog for MIRLET7F2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for MIRLET7F2 Gene

ENSEMBL:
Gene Tree for MIRLET7F2 (if available)
TreeFam:
Gene Tree for MIRLET7F2 (if available)

Paralogs for MIRLET7F2 Gene

No data available for Paralogs for MIRLET7F2 Gene

Variants for MIRLET7F2 Gene

Sequence variations from dbSNP and Humsavar for MIRLET7F2 Gene

SNP ID Clin Chr 0X pos Sequence Context AA Info Type
rs1003242406 -- 53,558,329(+) GGGCG(A/G)CTAAG intron-variant, upstream-variant-2KB
rs1003462106 -- 53,557,720(+) AGCAA(G/T)AATTT intron-variant, upstream-variant-2KB
rs1005715069 -- 53,557,551(+) TGCTT(C/T)GGCCA intron-variant, upstream-variant-2KB
rs1015898204 -- 53,556,800(+) TAGCC(A/G)TGTAA intron-variant, downstream-variant-500B, upstream-variant-2KB
rs1015927913 -- 53,557,166(+) AACAG(A/G)GCCAG intron-variant, downstream-variant-500B, upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for MIRLET7F2 Gene

Variant ID Type Subtype PubMed ID
esv2740175 CNV deletion 23290073
esv3576879 CNV gain 25503493
nsv435891 CNV deletion 17901297

Relevant External Links for MIRLET7F2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MIRLET7F2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Variation tolerance for MIRLET7F2 Gene

Disorders for MIRLET7F2 Gene

Relevant External Links for MIRLET7F2

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
MIRLET7F2

No disorders were found for MIRLET7F2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MIRLET7F2 Gene

Publications for MIRLET7F2 Gene

  1. Association of MicroRNAs and YRNAs With Platelet Function. (PMID: 26646931) Kaudewitz D … Mayr M (Circulation research 2016) 3 60
  2. Circulating microRNAs as potential biomarkers for endometriosis. (PMID: 25772772) Cho S … Taylor HS (Fertility and sterility 2015) 3 60
  3. Let-7f Inhibits Glioma Cell Proliferation, Migration, and Invasion by Targeting Periostin. (PMID: 25735962) Yan S … Li G (Journal of cellular biochemistry 2015) 3 60
  4. Plasma miRNAs as diagnostic and prognostic biomarkers for ovarian cancer. (PMID: 24223734) Zheng H … Chen K (PloS one 2013) 3 60
  5. miRBase: integrating microRNA annotation and deep-sequencing data. (PMID: 21037258) Kozomara A … Griffiths-Jones S (Nucleic acids research 2011) 3 60

Products for MIRLET7F2 Gene

Sources for MIRLET7F2 Gene

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