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Aliases for MIRLET7F2 Gene

Subcategory (RNA class) for MIRLET7F2 Gene

miRNA

Quality Score for this RNA gene is

3

Aliases for MIRLET7F2 Gene

  • MicroRNA Let-7f-2 2 3
  • MIRNLET7F2 3 6
  • LET7F2 3 6
  • Hsa-Let-7f-2 3
  • Let-7f-2 3

External Ids for MIRLET7F2 Gene

Previous HGNC Symbols for MIRLET7F2 Gene

  • MIRNLET7F2

Summaries for MIRLET7F2 Gene

Entrez Gene Summary for MIRLET7F2 Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIRLET7F2 Gene

MIRLET7F2 (MicroRNA Let-7f-2) is an RNA Gene, and is affiliated with the miRNA class. Among its related pathways are MicroRNAs in cancer.

No data available for UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MIRLET7F2 Gene

Genomics for MIRLET7F2 Gene

Genomic Location for MIRLET7F2 Gene

Start:
53,557,192 bp from pter
End:
53,557,274 bp from pter
Size:
83 bases
Orientation:
Minus strand

Genomic View for MIRLET7F2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for MIRLET7F2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIRLET7F2 Gene

No data available for Regulatory Elements for MIRLET7F2 Gene

Proteins for MIRLET7F2 Gene

Post-translational modifications for MIRLET7F2 Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIRLET7F2 Gene

Domains for MIRLET7F2 Gene

Gene Families for MIRLET7F2 Gene

HGNC:
  • MIR :ncRNAs / Micro RNAs

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with MIRLET7F2: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for MIRLET7F2 Gene

Function for MIRLET7F2 Gene

Animal Model Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for MIRLET7F2 Gene

Localization for MIRLET7F2 Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS and Gene Ontology (GO) - Cellular Components for MIRLET7F2 Gene

Pathways for MIRLET7F2 Gene

SuperPathways for MIRLET7F2 Gene

Superpath Contained pathways
1 MicroRNAs in cancer
genes like me logo Genes that share pathways with MIRLET7F2: view

Pathways by source for MIRLET7F2 Gene

1 KEGG pathway for MIRLET7F2 Gene

Interacting Proteins for MIRLET7F2 Gene

Gene Ontology (GO) - Biological Process for MIRLET7F2 Gene

None

Transcripts for MIRLET7F2 Gene

mRNA/cDNA for MIRLET7F2 Gene

(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

miRNA Products

  • QIAGEN qRT-PCR Assays for microRNAs that regulate MIRLET7F2
    • Block miRNA regulation of MIRLET7F2 using miScript Target Protectors

    Inhibitory RNA Products

    • Predesigned siRNA for gene silencing in human,mouse,rat for MIRLET7F2

    Primer Products

    Flow Cytometry Products

    Alternative Splicing Database (ASD) splice patterns (SP) for MIRLET7F2 Gene

    No ASD Table

    Relevant External Links for MIRLET7F2 Gene

    GeneLoc Exon Structure for
    MIRLET7F2
    ECgene alternative splicing isoforms for
    MIRLET7F2

    Expression for MIRLET7F2 Gene

    mRNA expression in normal human tissues for MIRLET7F2 Gene

    genes like me logo Genes that share expressions with MIRLET7F2: view

    In Situ Assay Products

    No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein expression and mRNA Expression by UniProt/SwissProt for MIRLET7F2 Gene

    Orthologs for MIRLET7F2 Gene

    This gene was present in the common ancestor of chordates.

    Orthologs for MIRLET7F2 Gene

    Organism Taxonomy Gene Similarity Type Details
    chimpanzee
    (Pan troglodytes)
    Mammalia ptr-let-7f-2 36
    • 100 (a)
    OneToOne
    cow
    (Bos Taurus)
    Mammalia bta-let-7f-2 36
    • 100 (a)
    OneToOne
    dog
    (Canis familiaris)
    Mammalia -- 36
    • 100 (a)
    OneToOne
    mouse
    (Mus musculus)
    Mammalia Mirlet7f-2 36
    • 100 (a)
    OneToOne
    oppossum
    (Monodelphis domestica)
    Mammalia mdo-let-7f-2 36
    • 94 (a)
    OneToOne
    platypus
    (Ornithorhynchus anatinus)
    Mammalia oan-let-7f-2 36
    • 59 (a)
    OneToOne
    chicken
    (Gallus gallus)
    Aves gga-let-7a-1 36
    • 83 (a)
    OneToOne
    lizard
    (Anolis carolinensis)
    Reptilia aca-let-7f-1 36
    • 78 (a)
    OneToOne
    zebrafish
    (Danio rerio)
    Actinopterygii dre-let-7a-1 36
    • 76 (a)
    OneToOne
    Species with no ortholog for MIRLET7F2:
    • A. gosspyii yeast (Ashbya gossypii)
    • Actinobacteria (Mycobacterium tuberculosis)
    • African clawed frog (Xenopus laevis)
    • African malaria mosquito (Anopheles gambiae)
    • Alicante grape (Vitis vinifera)
    • alpha proteobacteria (Wolbachia pipientis)
    • amoeba (Dictyostelium discoideum)
    • Archea (Pyrococcus horikoshii)
    • baker's yeast (Saccharomyces cerevisiae)
    • barley (Hordeum vulgare)
    • beta proteobacteria (Neisseria meningitidis)
    • bread mold (Neurospora crassa)
    • Chromalveolata (Phytophthora infestans)
    • common water flea (Daphnia pulex)
    • corn (Zea mays)
    • E. coli (Escherichia coli)
    • filamentous fungi (Aspergillus nidulans)
    • Firmicute bacteria (Streptococcus pneumoniae)
    • fission yeast (Schizosaccharomyces pombe)
    • fruit fly (Drosophila melanogaster)
    • green algae (Chlamydomonas reinhardtii)
    • honey bee (Apis mellifera)
    • K. lactis yeast (Kluyveromyces lactis)
    • loblloly pine (Pinus taeda)
    • malaria parasite (Plasmodium falciparum)
    • medicago trunc (Medicago Truncatula)
    • moss (Physcomitrella patens)
    • orangutan (Pongo pygmaeus)
    • pig (Sus scrofa)
    • rainbow trout (Oncorhynchus mykiss)
    • rat (Rattus norvegicus)
    • rice (Oryza sativa)
    • rice blast fungus (Magnaporthe grisea)
    • schistosome parasite (Schistosoma mansoni)
    • sea anemone (Nematostella vectensis)
    • sea squirt (Ciona intestinalis)
    • sea squirt (Ciona savignyi)
    • sea urchin (Strongylocentrotus purpuratus)
    • sorghum (Sorghum bicolor)
    • soybean (Glycine max)
    • stem rust fungus (Puccinia graminis)
    • sugarcane (Saccharum officinarum)
    • thale cress (Arabidopsis thaliana)
    • tomato (Lycopersicon esculentum)
    • toxoplasmosis (Toxoplasma gondii)
    • Trichoplax (Trichoplax adhaerens)
    • tropical clawed frog (Silurana tropicalis)
    • wheat (Triticum aestivum)
    • worm (Caenorhabditis elegans)

    Evolution for MIRLET7F2 Gene

    ENSEMBL:
    Gene Tree for MIRLET7F2 (if available)
    TreeFam:
    Gene Tree for MIRLET7F2 (if available)

    Paralogs for MIRLET7F2 Gene

    No data available for Paralogs for MIRLET7F2 Gene

    Variants for MIRLET7F2 Gene

    Structural Variations from Database of Genomic Variants (DGV) for MIRLET7F2 Gene

    Variant ID Type Subtype PubMed ID
    nsv435891 CNV Deletion 17901297
    esv2740175 CNV Deletion 23290073

    Relevant External Links for MIRLET7F2 Gene

    HapMap Linkage Disequilibrium report
    MIRLET7F2

    No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Sequence variations from dbSNP and Humsavar for MIRLET7F2 Gene

    Disorders for MIRLET7F2 Gene

    No disorders were found for MIRLET7F2 Gene.

    No data available for UniProtKB/Swiss-Prot for MIRLET7F2 Gene

    Publications for MIRLET7F2 Gene

    1. Identification of novel genes coding for small expressed RNAs. (PMID: 11679670) Lagos-Quintana M. … Tuschl T. (Science 2001) 3
    2. Reduced accumulation of specific microRNAs in colorectal neoplasia. (PMID: 14573789) Michael M.Z. … James R.J. (Mol. Cancer Res. 2003) 3
    3. Altered expression profiles of microRNAs during TPA-induced differentiation of HL-60 cells. (PMID: 15325244) Kasashima K. … Kozu T. (Biochem. Biophys. Res. Commun. 2004) 3
    4. miRBase: microRNA sequences, targets and gene nomenclature. (PMID: 16381832) Griffiths-Jones S. … Enright A.J. (Nucleic Acids Res. 2006) 3
    5. The tumor suppressor microRNA let-7 represses the HMGA2 oncogene. (PMID: 17437991) Lee Y.S. … Dutta A. (Genes Dev. 2007) 3

    Products for MIRLET7F2 Gene

    Sources for MIRLET7F2 Gene

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