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Aliases for MIRLET7F1 Gene

Subcategory (RNA class) for MIRLET7F1 Gene

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Quality Score for this RNA gene is

3

Aliases for MIRLET7F1 Gene

  • MicroRNA Let-7f-1 2 3 5
  • Hsa-Let-7f-1 3
  • MIRNLET7F1 3
  • Let-7f-1 3
  • LET7F1 3

External Ids for MIRLET7F1 Gene

ORGUL Members for MIRLET7F1 Gene

Previous HGNC Symbols for MIRLET7F1 Gene

  • MIRNLET7F1

Previous GeneCards Identifiers for MIRLET7F1 Gene

  • GC09P095983
  • GC09P096939
  • GC09P096943
  • GC09P096945
  • GC09P096951
  • GC09P096956
  • GC09P094177
  • GC09P094179
  • GC09P094180
  • GC09P094181
  • GC09P094182

Summaries for MIRLET7F1 Gene

Entrez Gene Summary for MIRLET7F1 Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIRLET7F1 Gene

MIRLET7F1 (MicroRNA Let-7f-1) is an RNA Gene, and is affiliated with the undefined RNA class. Among its related pathways are miRNAs involved in DNA damage response and Metastatic brain tumor.

No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MIRLET7F1 Gene

Genomics for MIRLET7F1 Gene

Regulatory Elements for MIRLET7F1 Gene

Enhancers for MIRLET7F1 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH09G094083 1.1 Ensembl ENCODE 9.7 -91.4 -91384 2.1 TBP BMI1 SP5 CEBPB HDAC8 ZNF592 RFX3 ZBTB33 IRF1 FOXJ2 MIRLET7D MIRLET7A1 MIRLET7F1 PTPDC1 CYCSP24 LOC105376152
GH09G094212 0.9 ENCODE 11.3 +36.3 36323 0.9 HDAC1 ATF1 TBL1XR1 CHAMP1 TCF12 ZNF766 ELK1 GATA2 CREM NCOA1 MIRLET7D MIRLET7F1 MIRLET7A1 ENSG00000269946 LOC100132077 MIRLET7DHG PIR33030
GH09G094065 0.9 Ensembl ENCODE 11.2 -110.6 -110647 0.6 CTCF ZNF654 IRF2 ARNT TRIM22 REST RAD21 MEF2D ZNF143 SMC3 MIRLET7A1 MIRLET7F1 MIRLET7D CYCSP24 LOC105376152
GH09G094110 0.9 ENCODE 10.7 -65.3 -65297 1.0 HDAC1 PKNOX1 ATF1 TBL1XR1 ARNT ZBTB40 TCF12 GATA2 CEBPB NCOA1 MIRLET7A1 MIRLET7D MIRLET7F1 BARX1-AS1 LOC105376152 CYCSP24
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around MIRLET7F1 on UCSC Golden Path with GeneCards custom track

Genomic Location for MIRLET7F1 Gene

Chromosome:
9
Start:
94,176,347 bp from pter
End:
94,176,433 bp from pter
Size:
87 bases
Orientation:
Plus strand

Genomic View for MIRLET7F1 Gene

Genes around MIRLET7F1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MIRLET7F1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIRLET7F1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIRLET7F1 Gene

Proteins for MIRLET7F1 Gene

Post-translational modifications for MIRLET7F1 Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIRLET7F1 Gene

Domains & Families for MIRLET7F1 Gene

Gene Families for MIRLET7F1 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with MIRLET7F1: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for MIRLET7F1 Gene

Function for MIRLET7F1 Gene

Animal Model Products

miRNA Products

Clone Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIRLET7F1 Gene

Localization for MIRLET7F1 Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS and Gene Ontology (GO) - Cellular Components for MIRLET7F1 Gene

Pathways & Interactions for MIRLET7F1 Gene

genes like me logo Genes that share pathways with MIRLET7F1: view

Pathways by source for MIRLET7F1 Gene

2 BioSystems pathways for MIRLET7F1 Gene
1 KEGG pathway for MIRLET7F1 Gene

Interacting Proteins for MIRLET7F1 Gene

Gene Ontology (GO) - Biological Process for MIRLET7F1 Gene

None

No data available for SIGNOR curated interactions for MIRLET7F1 Gene

Transcripts for MIRLET7F1 Gene

mRNA/cDNA for MIRLET7F1 Gene

(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Alternative Splicing Database (ASD) splice patterns (SP) for MIRLET7F1 Gene

No ASD Table

Relevant External Links for MIRLET7F1 Gene

GeneLoc Exon Structure for
MIRLET7F1
ECgene alternative splicing isoforms for
MIRLET7F1

Expression for MIRLET7F1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for MIRLET7F1 Gene

NURSA nuclear receptor signaling pathways regulating expression of MIRLET7F1 Gene:

MIRLET7F1
genes like me logo Genes that share expression patterns with MIRLET7F1: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for MIRLET7F1 Gene

Orthologs for MIRLET7F1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for MIRLET7F1 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia bta-let-7f-1 35
  • 100 (a)
OneToOne
dog
(Canis familiaris)
Mammalia cfa-let-7f 35
  • 100 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia mdo-let-7f-1 35
  • 100 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia ptr-let-7f-1 35
  • 100 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Gm24111 35
  • 52 (a)
ManyToMany
platypus
(Ornithorhynchus anatinus)
Mammalia oan-let-7e 35
  • 46 (a)
ManyToMany
chicken
(Gallus gallus)
Aves gga-let-7f 35
  • 88 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia aca-let-7f-2 35
  • 54 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii dre-let-7f 35
  • 66 (a)
OneToOne
Species where no ortholog for MIRLET7F1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for MIRLET7F1 Gene

ENSEMBL:
Gene Tree for MIRLET7F1 (if available)
TreeFam:
Gene Tree for MIRLET7F1 (if available)

Paralogs for MIRLET7F1 Gene

No data available for Paralogs for MIRLET7F1 Gene

Variants for MIRLET7F1 Gene

Sequence variations from dbSNP and Humsavar for MIRLET7F1 Gene

SNP ID Clin Chr 09 pos Sequence Context AA Info Type
rs1001069410 -- 94,174,436(+) CCTCT(C/T)TGCTT upstream-variant-2KB
rs1001242486 -- 94,174,454(+) AGGTT(A/G)AGGGG upstream-variant-2KB
rs1001589170 -- 94,174,757(+) TTCTC(C/T)GCATC upstream-variant-2KB
rs1002261112 -- 94,176,065(+) AGGCG(G/T)TCTGA downstream-variant-500B, upstream-variant-2KB
rs1002305969 -- 94,175,091(+) TTATA(C/T)TGAGC upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for MIRLET7F1 Gene

Variant ID Type Subtype PubMed ID
nsv831655 CNV gain 17160897

Relevant External Links for MIRLET7F1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MIRLET7F1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Variation tolerance for MIRLET7F1 Gene

Disorders for MIRLET7F1 Gene

Relevant External Links for MIRLET7F1

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
MIRLET7F1

No disorders were found for MIRLET7F1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MIRLET7F1 Gene

Publications for MIRLET7F1 Gene

  1. MicroRNA-let-7f-1 is induced by lycopene and inhibits cell proliferation and triggers apoptosis in prostate cancer. (PMID: 26847233) Li D. … An R. (Mol Med Rep 2016) 3 64
  2. Let-7f Inhibits Glioma Cell Proliferation, Migration, and Invasion by Targeting Periostin. (PMID: 25735962) Yan S. … Li G. (J. Cell. Biochem. 2015) 3 64
  3. Circulating microRNAs as potential biomarkers for endometriosis. (PMID: 25772772) Cho S. … Taylor H.S. (Fertil. Steril. 2015) 3 64
  4. Let-7f microRNA negatively regulates hepatic differentiation of human adipose tissue-derived stem cells. (PMID: 25077652) Davoodian N. … Arjmand S. (J. Physiol. Biochem. 2014) 3 64
  5. miR-let-7f-1 regulates SPARC mediated cisplatin resistance in medulloblastoma cells. (PMID: 25014664) Pannuru P. … Lakka S.S. (Cell. Signal. 2014) 3 64

Products for MIRLET7F1 Gene

Sources for MIRLET7F1 Gene

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