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Aliases for MIRLET7E Gene

Subcategory (RNA class) for MIRLET7E Gene

miRNA

Quality Score for this RNA gene is

3

Aliases for MIRLET7E Gene

  • MicroRNA Let-7e 2 3 5
  • Hsa-Let-7e 3
  • MIRNLET7E 3
  • Let-7e 3
  • LET7E 3

External Ids for MIRLET7E Gene

ORGUL Members for MIRLET7E Gene

Previous HGNC Symbols for MIRLET7E Gene

  • MIRNLET7E

Previous GeneCards Identifiers for MIRLET7E Gene

  • GC19P056923
  • GC19P056927
  • GC19P052200
  • GC19P052204
  • GC19P052212
  • GC19P052220
  • GC19P051693
  • GC19P051697
  • GC19P051700
  • GC19P051704

Summaries for MIRLET7E Gene

Entrez Gene Summary for MIRLET7E Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIRLET7E Gene

MIRLET7E (MicroRNA Let-7e) is an RNA Gene, and is affiliated with the miRNA class. Among its related pathways are Toll-like receptor signaling pathway and MicroRNAs in cancer.

No data available for UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MIRLET7E Gene

Genomics for MIRLET7E Gene

Regulatory Elements for MIRLET7E Gene

Enhancers for MIRLET7E Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH19F051545 1.7 FANTOM5 Ensembl ENCODE 10.5 -143.0 -142972 8.1 HDGF PKNOX1 ARNT MLX CREB3L1 ZFP64 ARID4B SIN3A DMAP1 YY1 ZNF175 SIGLEC14 SIGLEC6 SIGLEC5 SIGLEC8 CEACAM18 ENSG00000269102 SIGLEC12 RPL7P51 LOC100419835
GH19F051438 0.9 Ensembl ENCODE 9.9 -254.0 -254002 0.8 CTCF PKNOX1 TEAD4 CEBPB TRIM22 MIER2 CEBPG REST RAD21 IKZF1 SIGLEC12 CEACAM18 VSIG10L SIGLEC14 SIGLEC5 RPL7P51 NKG7 CLDND2 ETFB MIR125A
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around MIRLET7E on UCSC Golden Path with GeneCards custom track

Genomic Location for MIRLET7E Gene

Chromosome:
19
Start:
51,692,786 bp from pter
End:
51,692,864 bp from pter
Size:
79 bases
Orientation:
Plus strand

Genomic View for MIRLET7E Gene

Genes around MIRLET7E on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MIRLET7E Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIRLET7E Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIRLET7E Gene

Proteins for MIRLET7E Gene

Post-translational modifications for MIRLET7E Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIRLET7E Gene

Domains & Families for MIRLET7E Gene

Gene Families for MIRLET7E Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with MIRLET7E: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for MIRLET7E Gene

Function for MIRLET7E Gene

Animal Model Products

miRNA Products

Clone Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIRLET7E Gene

Localization for MIRLET7E Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS and Gene Ontology (GO) - Cellular Components for MIRLET7E Gene

Pathways & Interactions for MIRLET7E Gene

genes like me logo Genes that share pathways with MIRLET7E: view

Pathways by source for MIRLET7E Gene

1 KEGG pathway for MIRLET7E Gene

Interacting Proteins for MIRLET7E Gene

Gene Ontology (GO) - Biological Process for MIRLET7E Gene

None

No data available for SIGNOR curated interactions for MIRLET7E Gene

Transcripts for MIRLET7E Gene

mRNA/cDNA for MIRLET7E Gene

(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

miRNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for MIRLET7E Gene

No ASD Table

Relevant External Links for MIRLET7E Gene

GeneLoc Exon Structure for
MIRLET7E
ECgene alternative splicing isoforms for
MIRLET7E

Expression for MIRLET7E Gene

NURSA nuclear receptor signaling pathways regulating expression of MIRLET7E Gene:

MIRLET7E
No Expression Related Data Available

No data available for mRNA expression in normal human tissues , mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners and mRNA Expression by UniProt/SwissProt for MIRLET7E Gene

Orthologs for MIRLET7E Gene

This gene was present in the common ancestor of chordates.

Orthologs for MIRLET7E Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia bta-let-7e 35
  • 100 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia ptr-let-7e 35
  • 100 (a)
OneToOne
dog
(Canis familiaris)
Mammalia cfa-let-7e 35
  • 99 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia oan-let-7f-1 35
  • 29 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia -- 35
  • 55 (a)
ManyToMany
zebrafish
(Danio rerio)
Actinopterygii dre-let-7a-4 35
  • 58 (a)
ManyToMany
Species where no ortholog for MIRLET7E was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for MIRLET7E Gene

ENSEMBL:
Gene Tree for MIRLET7E (if available)
TreeFam:
Gene Tree for MIRLET7E (if available)

Paralogs for MIRLET7E Gene

No data available for Paralogs for MIRLET7E Gene

Variants for MIRLET7E Gene

Sequence variations from dbSNP and Humsavar for MIRLET7E Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type
rs10404453 -- 51,693,235(+) CTACC(A/G)GGCCA intron-variant, nc-transcript-variant, downstream-variant-500B, upstream-variant-2KB, utr-variant-5-prime
rs111708183 -- 51,693,116(+) AGGTC(G/T)CTGCC intron-variant, nc-transcript-variant, downstream-variant-500B, upstream-variant-2KB, utr-variant-5-prime
rs113906081 -- 51,691,202(+) AGAAA(-/AG)AGAGA intron-variant, upstream-variant-2KB
rs116185360 -- 51,691,939(+) CTCAG(A/C)CCCCT intron-variant, upstream-variant-2KB, utr-variant-5-prime
rs11668874 -- 51,691,696(+) ACTGC(C/G)AGAAA intron-variant, upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for MIRLET7E Gene

Variant ID Type Subtype PubMed ID
nsv9742 CNV gain+loss 18304495
nsv953608 CNV deletion 24416366
nsv1140251 OTHER inversion 24896259
esv2758767 CNV gain+loss 17122850

Relevant External Links for MIRLET7E Gene

Human Gene Mutation Database (HGMD)
MIRLET7E
SNPedia medical, phenotypic, and genealogical associations of SNPs for
MIRLET7E

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Variation tolerance for MIRLET7E Gene

Disorders for MIRLET7E Gene

Relevant External Links for MIRLET7E

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
MIRLET7E

No disorders were found for MIRLET7E Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MIRLET7E Gene

Publications for MIRLET7E Gene

  1. Downregulation of let-7e-5p contributes to endothelial progenitor cell dysfunction in deep vein thrombosis via targeting FASLG. (PMID: 26826505) Kong L. … Li C. (Thromb. Res. 2016) 3 64
  2. Signature of circulating microRNAs in osteoarthritis. (PMID: 24515954) Beyer C. … Kiechl S. (Ann. Rheum. Dis. 2015) 3 64
  3. Over-expression of cofilin-1 suppressed growth and invasion of cancer cells is associated with up-regulation of let-7 microRNA. (PMID: 25597880) Tsai C.H. … Lee Y.J. (Biochim. Biophys. Acta 2015) 3 64
  4. Micro-RNAs Let7e and 126 in Plasma as Markers of Metabolic Dysfunction in 10 to 12 Years Old Children. (PMID: 26046362) Krause B.J. … Casanello P. (PLoS ONE 2015) 3 64
  5. Differential expression of miR-125a-5p and let-7e predicts the progression and prognosis of non-small cell lung cancer. (PMID: 24945821) Zhu W.Y. … Zhang Y.K. (Cancer Invest. 2014) 3 64

Products for MIRLET7E Gene

Sources for MIRLET7E Gene

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