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Aliases for MIRLET7E Gene

Subcategory (RNA class) for MIRLET7E Gene


Quality Score for this RNA gene is


Aliases for MIRLET7E Gene

  • MicroRNA Let-7e 2 3
  • Hsa-Let-7e 3
  • Let-7e 3
  • LET7E 3

External Ids for MIRLET7E Gene

Previous HGNC Symbols for MIRLET7E Gene


Previous GeneCards Identifiers for MIRLET7E Gene

  • GC19P056923
  • GC19P056927
  • GC19P052200
  • GC19P052204
  • GC19P052212
  • GC19P052220
  • GC19P051693

Summaries for MIRLET7E Gene

Entrez Gene Summary for MIRLET7E Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIRLET7E Gene

MIRLET7E (MicroRNA Let-7e) is an RNA Gene, and is affiliated with the miRNA class. Among its related pathways are MicroRNAs in cancer.

No data available for UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MIRLET7E Gene

Genomics for MIRLET7E Gene

Genomic Location for MIRLET7E Gene

51,692,773 bp from pter
51,692,881 bp from pter
109 bases
Plus strand

Genomic View for MIRLET7E Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for MIRLET7E Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIRLET7E Gene

No data available for Regulatory Elements for MIRLET7E Gene

Proteins for MIRLET7E Gene

Post-translational modifications for MIRLET7E Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIRLET7E Gene

Domains & Families for MIRLET7E Gene

Gene Families for MIRLET7E Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with MIRLET7E: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for MIRLET7E Gene

Function for MIRLET7E Gene

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIRLET7E Gene

Localization for MIRLET7E Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS and Gene Ontology (GO) - Cellular Components for MIRLET7E Gene

Pathways & Interactions for MIRLET7E Gene

SuperPathways for MIRLET7E Gene

Superpath Contained pathways
1 MicroRNAs in cancer
genes like me logo Genes that share pathways with MIRLET7E: view

Pathways by source for MIRLET7E Gene

1 KEGG pathway for MIRLET7E Gene

Interacting Proteins for MIRLET7E Gene

Gene Ontology (GO) - Biological Process for MIRLET7E Gene


No data available for SIGNOR curated interactions for MIRLET7E Gene

Drugs & Compounds for MIRLET7E Gene

No Compound Related Data Available

Transcripts for MIRLET7E Gene


(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Alternative Splicing Database (ASD) splice patterns (SP) for MIRLET7E Gene

No ASD Table

Relevant External Links for MIRLET7E Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for MIRLET7E Gene

No Expression Related Data Available

Primer Products

  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

In Situ Assay Products

No data available for mRNA expression in normal human tissues , mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , mRNA Expression by UniProt/SwissProt and Protein tissue co-expression partners for MIRLET7E Gene

Orthologs for MIRLET7E Gene

This gene was present in the common ancestor of chordates.

Orthologs for MIRLET7E Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia bta-let-7e 36
  • 100 (a)
(Canis familiaris)
Mammalia cfa-let-7e 36
  • 99 (a)
(Ornithorhynchus anatinus)
Mammalia oan-let-7f-1 36
  • 29 (a)
(Pan troglodytes)
Mammalia ptr-let-7e 36
  • 100 (a)
(Anolis carolinensis)
Reptilia -- 36
  • 55 (a)
(Danio rerio)
Actinopterygii dre-let-7a-4 36
  • 58 (a)
Species with no ortholog for MIRLET7E:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for MIRLET7E Gene

Gene Tree for MIRLET7E (if available)
Gene Tree for MIRLET7E (if available)

Paralogs for MIRLET7E Gene

No data available for Paralogs for MIRLET7E Gene

Variants for MIRLET7E Gene

Structural Variations from Database of Genomic Variants (DGV) for MIRLET7E Gene

Variant ID Type Subtype PubMed ID
dgv1109e1 CNV Complex 17122850
esv638 CNV CNV 17122850
dgv1110e1 CNV Complex 17122850
nsv912296 CNV Loss 21882294
nsv9742 CNV Gain+Loss 18304495

Relevant External Links for MIRLET7E Gene

HapMap Linkage Disequilibrium report
Human Gene Mutation Database (HGMD)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Sequence variations from dbSNP and Humsavar and Variation tolerance for MIRLET7E Gene

Disorders for MIRLET7E Gene

Relevant External Links for MIRLET7E

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
genes like me logo Genes that share disorders with MIRLET7E: view

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MIRLET7E Gene

Publications for MIRLET7E Gene

  1. Signature of circulating microRNAs in osteoarthritis. (PMID: 24515954) Beyer C. … Kiechl S. (Ann. Rheum. Dis. 2015) 67
  2. Over-expression of cofilin-1 suppressed growth and invasion of cancer cells is associated with up-regulation of let-7 microRNA. (PMID: 25597880) Tsai C.H. … Lee Y.J. (Biochim. Biophys. Acta 2015) 67
  3. Differential expression of miR-125a-5p and let-7e predicts the progression and prognosis of non-small cell lung cancer. (PMID: 24945821) Zhu W.Y. … Zhang Y.K. (Cancer Invest. 2014) 67
  4. Cutting edge: a variant of the IL-23R gene associated with inflammatory bowel disease induces loss of microRNA regulation and enhanced protein production. (PMID: 22262659) Zwiers A. … Kraal G. (J. Immunol. 2012) 67
  5. Jumonji/ARID1 B (JARID1B) protein promotes breast tumor cell cycle progression through epigenetic repression of microRNA let-7e. (PMID: 21969366) Mitra D. … Jones F.E. (J. Biol. Chem. 2011) 67

Products for MIRLET7E Gene

Sources for MIRLET7E Gene

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