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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

MIRLET7E Gene

RNA gene GIFtS: 23
GCID: GC19P052204

microRNA let-7e

(Previous symbol: MIRNLET7E)

Explore 3 diseases affiliated with
MIRLET7E via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Subcategory (RNA class): miRNA

Quality score for this RNA gene is 20

Aliases
MicroRNA Let-7e¹ ²
MIRNLET7E¹ ²
Hsa-Let-7e¹
Let-7e¹

External Ids:	HGNC: 31482¹	Entrez Gene: 406887²	Ensembl: ENSG00000198972⁷	OMIM: 611250⁵

ORGUL members:	fRNAdb¹⁰:FR295852 FR322128 FR295852
	miRBase: MI0000066 MIMAT0000066 MIMAT0004485
	NCBI:AK125996 AC018755
	Rfam:RF00027

Export aliases for MIRLET7E gene to outside databases

Previous GC identifers: GC19P056923 GC19P056927 GC19P052200

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for MIRLET7E:

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene

expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed

by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either

protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an

approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer

ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated

into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the

miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq

represents the predicted microRNA stem-loop. (provided by RefSeq, Sep 2009)

fRNAdb sequence ontology for MIRLET7E:
pre_miRNA - The 60-70 nucleotide region remain after Drosha processing of the primary transcript, that folds back upon itself to form a hairpin sructure.

View fRNAdb secondary structures for MIRLET7E

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

Regulatory elements:

Search SABiosciences Regulatory transcription factor binding sites for MIRLET7E
Other transcription factors

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Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat MIRLET7E

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 19q13.41 Ensembl cytogenetic band: 19q13.41 HGNC cytogenetic band: 19q13.41

MIRLET7E Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
MIRLET7E gene location

GeneLoc information about chromosome 19 GeneLoc Exon Structure

GeneLoc location for GC19P052204: view genomic region (via miRBase) (about GC identifiers)

Start:	52,196,039 bp from pter	End:	52,196,117 bp from pter
Size:	79 bases	Orientation:	plus strand

ORGUL member locations:
Legend (see complete legend)

ORGUL Member Locations for MIRLET7E

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB: --

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, Sirion Biotech, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, Sirion Biotech, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Animal Models:

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(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Interactions:

Search SABiosciences Gene Network Central^TM Interacting Genes and Proteins Networks for MIRLET7E

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for MIRLET7E
Search CenterWatch for drugs/clinical trials and news about MIRLET7E

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
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About This Section

2 fRNAdb Secondary structures:

1 Ensembl transcript including schematic representation, and UCSC links where relevant:

ENST00000362102(miRNA)

miRNA Products:		Browse 3'-UTR reporter clones for miRNA target validation Browse OriGene MicroRNA Expression Plasmids
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GeneLoc Exon Structure

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

Expression evidence for MIRLET7E:miRBase

MIRLET7E expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: --

About this image SABiosciences Custom PCR Arrays for MIRLET7E

Primer Products:		Browse OriGene genome-wide validated SYBR primer pairs Browse OriGene validated miRNA SYBR primer pairs
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In Situ
Assay Products:

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(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

--

ENSEMBL Gene Tree for MIRLET7E (if available)
TreeFam Gene Tree for MIRLET7E (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for MIRLET7E gene

MIRLET7B² MIRLET7C² MIRLET7I² MIRLET7A2² MIRLET7F2² MIRLET7D² MIR98² MIRLET7F1²

MIRLET7G² MIRLET7A1² MIRLET7A3²

MIRLET7E for paralogs About GeneDecksing

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 19 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs184192417^1,2		--	52194136(+)	`CAGGCC/TTGGGC`	2	--	us2k¹		0	--	--	--	--
rs145039573^1,2		--	52194145(+)	`GCTCCA/GGGCCA`	2	--	us2k¹		0	--	--	--	--
rs188897040^1,2		--	52194188(+)	`CTCCTC/TCCTTC`	2	--	us2k¹		0	--	--	--	--
rs140340683^1,2	C	--	52194275(+)	`GAGCT-/GGGGCCG`	2	--	us2k¹		0	--	--	--	--
rs75277661^1,2	C	--	52194348(+)	`CCCTCA/CTCAGG`	2	--	us2k¹		0	--	--	--	--
rs79689162^1,2	C	--	52194349(+)	`CCTCCG/TCAGGT`	2	--	us2k¹		0	--	--	--	--
rs148869650^1,2	C	--	52194349(+)	`CTCCT-/CAGCAGGT`	2	--	us2k¹		0	--	--	--	--
rs75358052^1,2	C	--	52194428(+)	`GCTGCG/AAGGGG`	2	--	us2k¹		1		WA	2
rs80083870^1,2	C	--	52194455(+)	`GAGAAA/GAGAGA`	2	--	us2k¹		0	--	--	--	--
rs113906081^1,2	C	--	52194455(+)	`AGAAAAG/-AGAGA`	2	--	us2k¹		1		CSA	2

HapMap Linkage Disequilibrium report for MIRLET7E (52196039 - 52196117 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 3 variations for MIRLET7E
3 CNVs: 30914 32264 4085
Human Gene Mutation Database (HGMD): MIRLET7E

SABiosciences Cancer Mutation PCR Assays

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

MIRLET7E for disorders           About GeneDecksing

OMIM gene information: 611250    OMIM disorders: --

3 diseases for MIRLET7E:    About MalaCards

cervical cancer cervicitis hepatitis

Export disorders for MIRLET7E gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

PubMed articles for MIRLET7E gene, integrated from 9 sources (see all 11):
(articles sorted by number of sources associating them with MIRLET7E)

Utopia: connect your pdf to the dynamic
world of online information

Cutting edge: a variant of the IL-23R gene associated with inflammatory bowel disease induces loss of microRNA regulation and enhanced protein production. (PubMed id 22262659)¹ Zwiers A....Kraal G. (2012)
Jumonji/ARID1 B (JARID1B) protein promotes breast tum or cell cycle progression through epigenetic repression of microRNA let-7e. (PubMed id 21969366)¹ Mitra D....Jones F.E. (2011)
Analysis of deep sequencing microRNA expression profi le from human embryonic stem cells derived mesenchymal stem cells reveals possi ble role of let-7 microRNA family in downstream targeting of hepatic nuclear fa ctor 4 alpha. (PubMed id 20158877)¹ Koh W....Tanavde V. (2010)
Patterns of known and novel small RNAs in human cervical cancer. (PubMed id 17616659)¹ Lui W.O....Fire A. (2007)
A mammalian microRNA expression atlas based on small RNA library sequencing. (PubMed id 17604727)¹ Landgraf P....Tuschl T. (2007)
The tumor suppressor microRNA let-7 represses the HMGA2 oncogene. (PubMed id 17437991)¹ Lee Y.S. and Dutta A. (2007)
miRBase: microRNA sequences, targets and gene nomencl ature. (PubMed id 16381832)¹ Griffiths-Jones S....Enright A.J. (2006)
Altered expression profiles of microRNAs during TPA-induced differentiation of HL-60 cells. (PubMed id 15325244)¹ Kasashima K....Kozu T. (2004)
Identification of novel genes coding for small expressed RNAs. (PubMed id 11679670)¹ Lagos-Quintana M....Tuschl T. (2001)
(PubMed id 11533718)¹⁰

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

Entrez Gene: 406887	HGNC: 31482	Ensembl:ENSG00000198972	miRBase: hsa-let-7e	euGenes: HUgn406887
ECgene: MIRLET7E	H-InvDB: MIRLET7E

(According to HUGE)
About This Section

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
PharmGKB entry for MIRLET7E	Pharmacogenomics, SNPs, Pathways

Intellectual Property for MIRLET7E gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

About This Section

Patent Information for MIRLET7E gene:
Search GeneIP for patents involving MIRLET7E

GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search

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for MIRLET7E gene

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for MIRLET7E gene

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for MIRLET7E gene

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for MIRLET7E gene

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for MIRLET7E gene

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for MIRLET7E gene

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for MIRLET7E gene

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for MIRLET7E gene

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for MIRLET7E gene

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for MIRLET7E gene