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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

MIRLET7D Gene

RNA gene   GIFtS: 27
GCID: GC09P096941

MicroRNA Let-7d


(Previous symbol: MIRNLET7D)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Subcategory (RNA class): miRNA

Quality score for this RNA gene is 13

Aliases
MicroRNA Let-7d1 2
MIRNLET7D1 2 5
let-7d2 9
LET7D2 5
hsa-let-7d2

External Ids:    HGNC: 314811   Entrez Gene: 4068862   Ensembl: ENSG000001991337   OMIM: 6121455   
ORGUL members:    fRNAdb10:FR277165 FR011440 FR027828      

Export aliases for MIRLET7D gene to outside databases

Previous GC identifer: GC09P095984


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for MIRLET7D Gene:
microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of
gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are
transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can
be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme
to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the
cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The
mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through
imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of
the target mRNA. The RefSeq represents the predicted microRNA stem-loop. (provided by RefSeq, Sep 2009)

GeneCards Summary for MIRLET7D Gene: 
MIRLET7D (microRNA let-7d) is an RNA gene, and is affiliated with the miRNA class. Diseases associated with MIRLET7D include oral cancer, and cervical cancer.




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
Regulatory elements:
   Search SABiosciences Regulatory transcription factor binding sites for MIRLET7D
         Other transcription factors

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Epigenetics:
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Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 9q22.32   Ensembl cytogenetic band:  9q22.32   HGNC cytogenetic band: 9q22.32

MIRLET7D Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
MIRLET7D gene location

GeneLoc information about chromosome 9         GeneLoc Exon Structure

GeneLoc location for GC09P096941:  view genomic region (via miRBase)     (about GC identifiers)

Start:
96,941,116 bp from pter      End:
96,941,202 bp from pter
Size:
87 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB: --


(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section
HGNC Gene Families: 
MIR: ncRNAs / Micro RNAs

  --

(According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
About This Section

Animal Models:
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(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
About This Section

SuperPaths for MIRLET7D About                                                                                                See pathways by source

SuperPathContained pathways About
1MicroRNAs in cancer
MicroRNAs in cancer
2miRNAs involved in DDR
miRNAs involved in DDR

Pathways by source                                                                                                                                                                 See SuperPaths
Show all pathways


1 BioSystems Pathway for MIRLET7D
    miRNAs involved in DDR


1         Kegg Pathway  (Kegg details for MIRLET7D):
    MicroRNAs in cancer


MIRLET7D for pathways           About GeneDecksing

Interactions:

    Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for MIRLET7D

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section
Browse Small Molecules at EMD Millipore
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Browse Tocris compounds for MIRLET7D

Search CenterWatch for drugs/clinical trials and news about MIRLET7D

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

1 Ensembl transcript including schematic representation, and UCSC links where relevant:
ENST00000362263(miRNA)
miRNA
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GeneLoc Exon Structure


(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

Expression evidence for MIRLET7D:none

MIRLET7D expression in normal human tissues (normalized intensities)      MIRLET7D embryonic expression: see
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>2/3
CGAP TAG: --
MIRLET7D Expression
About this image


MIRLET7D expression in embryonic tissues and stem cells    About this table
Data from LifeMap, the Embryonic Development and Stem Cells Database 
 5/1 selected tissues (see all 1) fully expand
 
 Endothelium (Cardiovascular System)
         Peripheral blood-derived endothelial progenitor cells

Genevestigator expression for MIRLET7D
    SABiosciences Custom PCR Arrays for MIRLET7D
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In Situ
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(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of chordates.

Orthologs for MIRLET7D gene from 3/10 species (see all 10)    About this table
Organism Taxonomic
classification
Gene Description Human
Similarity
Orthology
Type
Details
chicken
(Gallus gallus)
Aves gga-let-7d6
gga-let-7d
75(a)
1 ↔ 1
12(6076930-6077032) ENSGALG00000018264
lizard
(Anolis carolinensis)
Reptilia aca-mir-986
aca-let-7d6
aca-let-7d
67(a)
63(a)
possible ortholog
1 ↔ 1
1(205025691-205025778)
GL343225.1(747531-747646)
zebrafish
(Danio rerio)
Actinopterygii mirlet7f6
mirlet7h6
microRNA let7h
51(a)
49(a)
many ↔ many
many ↔ many
11(28379857-28379972) ENSDARG00000082942
23(28779557-28779670) ENSDARG00000081815
        Species with no ortholog for MIRLET7D

ENSEMBL Gene Tree for MIRLET7D (if available)
TreeFam Gene Tree for MIRLET7D (if available)

(Paralogs according to 1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
  --

(SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
Structural Variations
     Database of Genomic Variants (DGV) 1 variation for MIRLET7D:    About this table     
Variant IDTypeSubtypePubMed ID
nsv831655CNV Gain17160897

SABiosciences Cancer Mutation PCR Assays
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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section
OMIM gene information: 612145    OMIM disorders: --

7 diseases for MIRLET7D:    About MalaCards
oral cancer    cervical cancer    lung cancer    cervicitis
glioblastoma    ovarian cancer    hepatitis


MIRLET7D for disorders           About GeneDecksing

Human Genome Epidemiology (HuGE) Navigator: MIRLET7D (1 document)

Export disorders for MIRLET7D gene to outside databases

(in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
About This Section

PubMed articles for MIRLET7D gene, integrated from 9 sources (see all 12):
(articles sorted by number of sources associating them with MIRLET7D)
    Utopia: connect your pdf to the dynamic
world of online information

  1. Olea europaea leaf extract alters microRNA expression in human glioblastoma cells. (PubMed id 22722712)1 Tunca B....Bilir A. (2012)
  2. Let-7 modulates acquired resistance of ovarian cancer to Taxanes via IMP-1-mediated stabilization of multidrug resistance 1. (PubMed id 21618519)1 Boyerinas B....Peter M.E. (2012)
  3. Let-7d functions as novel regulator of epithelial-mes enchymal transition and chemoresistant property in oral cancer. (PubMed id 21725603)1 Chang C.J....Hu F.W. (2011)
  4. Regulation of divalent metal transporter 1 (DMT1) non -IRE isoform by the microRNA Let-7d in erythroid cells. (PubMed id 20410187)1 Andolfo I....Iolascon A. (2010)
  5. Analysis of deep sequencing microRNA expression profi le from human embryonic stem cells derived mesenchymal stem cells reveals possi ble role of let-7 microRNA family in downstream targeting of hepatic nuclear fa ctor 4 alpha. (PubMed id 20158877)1 Koh W....Tanavde V. (2010)
  6. Genetic Polymorphisms in the pre-MicroRNA Flanking Re gion and Non-Small-Cell Lung Cancer Survival. (PubMed id 20889907)1 Hu Z....Shen H. (2010)
  7. Patterns of known and novel small RNAs in human cervical cancer. (PubMed id 17616659)1 Lui W.O....Fire A. (2007)
  8. A mammalian microRNA expression atlas based on small RNA library sequencing. (PubMed id 17604727)1 Landgraf P....Tuschl T. (2007)
  9. The tumor suppressor microRNA let-7 represses the HMGA2 oncogene. (PubMed id 17437991)1 Lee Y.S. and Dutta A. (2007)
  10. miRBase: microRNA sequences, targets and gene nomencl ature. (PubMed id 16381832)1 Griffiths-Jones S....Enright A.J. (2006)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section
 ANDOR
Aliases
Free Text  

  Query String
PubMed
OMIM
NCBI Bookshelf
  (Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section
Entrez Gene: 406886 HGNC: 31481 Ensembl:ENSG00000199133 miRBase: hsa-let-7d euGenes: HUgn406886
ECgene: MIRLET7D Kegg: 406886 H-InvDB: MIRLET7D

(According to HUGE)
About This Section
  --

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
NameDescription
PharmGKB entry for MIRLET7D Pharmacogenomics, SNPs, Pathways

(Patent information from GeneIP,
Licensable technologies from WIS Yeda, Salk, Tufts,
IP news from LifeMap Sciences, Inc.)
About This Section
Patent Information for MIRLET7D gene:
Search GeneIP for patents involving MIRLET7D

GeneCards and IP:
Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
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