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Aliases for MIRLET7D Gene

Subcategory (RNA class) for MIRLET7D Gene


Quality Score for this RNA gene is


Aliases for MIRLET7D Gene

  • MicroRNA Let-7d 2 3 5
  • Hsa-Let-7d 3
  • Let-7d 3
  • LET7D 3

External Ids for MIRLET7D Gene

ORGUL Members for MIRLET7D Gene

Previous HGNC Symbols for MIRLET7D Gene


Previous GeneCards Identifiers for MIRLET7D Gene

  • GC09P095984
  • GC09P096941

Summaries for MIRLET7D Gene

Entrez Gene Summary for MIRLET7D Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIRLET7D Gene

MIRLET7D (MicroRNA Let-7d) is an RNA Gene, and is affiliated with the miRNA class. Among its related pathways are MicroRNAs in cancer and miRNAs involved in DDR.

No data available for UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MIRLET7D Gene

Genomics for MIRLET7D Gene

Regulatory Elements for MIRLET7D Gene

Enhancers for MIRLET7D Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH09F094212 0.8 ENCODE 11.3 +33.8 33836 0.9 HDAC1 ATF1 TBL1XR1 CHAMP1 GATA2 CREM ZEB2 KLF16 SMARCA4 KDM1A MIRLET7D MIRLET7A1 MIRLET7F1 ENSG00000269946 LOC100132077 MIRLET7DHG PIR33030
GH09F094150 1.2 Ensembl ENCODE 11.2 -27.9 -27934 1.4 MIRLET7D MFSD14B LOC100132077 LOC105376152 ENSG00000269946
GH09F094156 1.2 Ensembl ENCODE 11.2 -21.8 -21834 1.6 ELF3 TBP HDAC1 CBX3 TBL1XR1 CREB3L1 NFRKB ZBTB40 ETV6 ZBTB2 MIRLET7D LOC100132077 ENSG00000269946 LOC105376152
GH09F094154 0.4 Ensembl 11.2 -24.7 -24734 0.2 MIRLET7D LOC105376152 ENSG00000269946
GH09F094065 0.8 Ensembl ENCODE 11.2 -113.1 -113064 0.5 MEF2D CTCF ZNF654 ARNT SMC3 TRIM22 REST RAD21 MIRLET7A1 MIRLET7D MIRLET7F1 CYCSP24 LOC105376152
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around MIRLET7D on UCSC Golden Path with GeneCards custom track

Genomic Location for MIRLET7D Gene

94,178,834 bp from pter
94,178,920 bp from pter
87 bases
Plus strand

Genomic View for MIRLET7D Gene

Genes around MIRLET7D on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MIRLET7D Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIRLET7D Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIRLET7D Gene

Proteins for MIRLET7D Gene

Post-translational modifications for MIRLET7D Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIRLET7D Gene

Domains & Families for MIRLET7D Gene

Gene Families for MIRLET7D Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with MIRLET7D: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for MIRLET7D Gene

Function for MIRLET7D Gene

Animal Model Products

miRNA for MIRLET7D Gene

miRTarBase miRNAs that target MIRLET7D

miRNA Products

Clone Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for MIRLET7D Gene

Localization for MIRLET7D Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS and Gene Ontology (GO) - Cellular Components for MIRLET7D Gene

Pathways & Interactions for MIRLET7D Gene

genes like me logo Genes that share pathways with MIRLET7D: view

Pathways by source for MIRLET7D Gene

1 BioSystems pathway for MIRLET7D Gene
1 KEGG pathway for MIRLET7D Gene

Interacting Proteins for MIRLET7D Gene

Gene Ontology (GO) - Biological Process for MIRLET7D Gene


No data available for SIGNOR curated interactions for MIRLET7D Gene

Transcripts for MIRLET7D Gene


(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

miRNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for MIRLET7D Gene

No ASD Table

Relevant External Links for MIRLET7D Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for MIRLET7D Gene

mRNA expression in normal human tissues for MIRLET7D Gene

NURSA nuclear receptor signaling pathways regulating expression of MIRLET7D Gene:

genes like me logo Genes that share expression patterns with MIRLET7D: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners and mRNA Expression by UniProt/SwissProt for MIRLET7D Gene

Orthologs for MIRLET7D Gene

This gene was present in the common ancestor of chordates.

Orthologs for MIRLET7D Gene

Organism Taxonomy Gene Similarity Type Details
(Canis familiaris)
Mammalia -- 35
  • 100 (a)
(Pan troglodytes)
Mammalia ptr-let-7d 35
  • 100 (a)
(Bos Taurus)
Mammalia bta-let-7d 35
  • 99 (a)
(Mus musculus)
Mammalia Mirlet7d 35
  • 77 (a)
(Monodelphis domestica)
Mammalia mdo-let-7d 35
  • 75 (a)
(Ornithorhynchus anatinus)
Mammalia oan-let-7d 35
  • 64 (a)
(Gallus gallus)
Aves gga-let-7d 35
  • 76 (a)
(Anolis carolinensis)
Reptilia aca-let-7d 35
  • 64 (a)
(Danio rerio)
Actinopterygii CR847944.3 35
  • 71 (a)
Species where no ortholog for MIRLET7D was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for MIRLET7D Gene

Gene Tree for MIRLET7D (if available)
Gene Tree for MIRLET7D (if available)

Paralogs for MIRLET7D Gene

No data available for Paralogs for MIRLET7D Gene

Variants for MIRLET7D Gene

Sequence variations from dbSNP and Humsavar for MIRLET7D Gene

SNP ID Clin Chr 09 pos Sequence Context AA Info Type
rs10081759 -- 94,178,130(+) tctaa(G/T)cccag intron-variant, upstream-variant-2KB
rs10122644 -- 94,177,871(+) TAATG(A/G)TGATA intron-variant, upstream-variant-2KB
rs10993081 -- 94,177,436(+) AATGT(A/G)TGCTT nc-transcript-variant, upstream-variant-2KB
rs10993082 -- 94,178,337(+) TAAAT(A/G)GTGAA intron-variant, upstream-variant-2KB
rs10993083 -- 94,179,396(+) GGGTA(A/G)TTGAG intron-variant, downstream-variant-500B

Structural Variations from Database of Genomic Variants (DGV) for MIRLET7D Gene

Variant ID Type Subtype PubMed ID
nsv831655 CNV gain 17160897

Relevant External Links for MIRLET7D Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Variation tolerance for MIRLET7D Gene

Disorders for MIRLET7D Gene

Relevant External Links for MIRLET7D

Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for MIRLET7D Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MIRLET7D Gene

Publications for MIRLET7D Gene

  1. Let-7d miRNA Shows Both Antioncogenic and Oncogenic Functions in Osteosarcoma-Derived 3AB-OS Cancer Stem Cells. (PMID: 26679758) Di Fiore R. … Vento R. (J. Cell. Physiol. 2016) 3 64
  2. Circulating MicroRNA Let-7d in Attention-Deficit/Hyperactivity Disorder. (PMID: 25724585) Wu L.H. … Wu X.Z. (Neuromolecular Med. 2015) 3 64
  3. Circulating microRNAs as potential biomarkers for endometriosis. (PMID: 25772772) Cho S. … Taylor H.S. (Fertil. Steril. 2015) 3 64
  4. Let-7 related genetic variation and risk of metabolic syndrome in a Chinese population. (PMID: 26178671) Yan Y.X. … He Y. (Endocr. J. 2015) 3 64
  5. Let-7d suppresses growth, metastasis, and tumor macrophage infiltration in renal cell carcinoma by targeting COL3A1 and CCL7. (PMID: 25193015) Su B. … Zhou L. (Mol. Cancer 2014) 3 64

Products for MIRLET7D Gene

Sources for MIRLET7D Gene

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