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Aliases for MIRLET7C Gene

Subcategory (RNA class) for MIRLET7C Gene


Quality Score for this RNA gene is


Aliases for MIRLET7C Gene

  • MicroRNA Let-7c 2 3 5
  • Hsa-Let-7c 3
  • Let-7c 3
  • LET7C 3

External Ids for MIRLET7C Gene

ORGUL Members for MIRLET7C Gene

Previous HGNC Symbols for MIRLET7C Gene


Previous GeneCards Identifiers for MIRLET7C Gene

  • GC21P016842
  • GC21P017912
  • GC21P016540
  • GC21P016541
  • GC21P016542
  • GC21P016544

Summaries for MIRLET7C Gene

Entrez Gene Summary for MIRLET7C Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIRLET7C Gene

MIRLET7C (MicroRNA Let-7c) is an RNA Gene, and is affiliated with the undefined RNA class. Among its related pathways are MicroRNAs in cancer.

No data available for UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MIRLET7C Gene

Genomics for MIRLET7C Gene

Regulatory Elements for MIRLET7C Gene

Enhancers for MIRLET7C Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH21F016563 1.3 Ensembl ENCODE 11.7 +24.1 24123 1.2 SOX13 TEAD4 MAX RAD21 RFX5 TEAD3 RCOR1 MAFK TCF7L2 CHD2 MIR99A MIRLET7C ENSG00000269950 PIR42144 GC21P016551
GH21F016578 2.3 VISTA Ensembl ENCODE 11.5 +40.2 40188 2.6 MAFK MIR99A MIRLET7C ENSG00000269950 PIR42144 GC21P016551
GH21F016573 1.3 Ensembl ENCODE 11.5 +34.0 34026 1.6 MIR99A MIRLET7C ENSG00000269950 GC21P016551 PIR42144
GH21F016570 0.7 ENCODE 11.5 +30.6 30600 0.4 MAFF CEBPB NFE2 EP300 MAFK NFE2L2 MIR99A MIRLET7C ENSG00000269950 GC21P016551 PIR42144
GH21F016572 0.6 ENCODE 11.5 +32.4 32408 0.2 ZNF680 MIR99A MIRLET7C ENSG00000269950 GC21P016551 PIR42144
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around MIRLET7C on UCSC Golden Path with GeneCards custom track

Genomic Location for MIRLET7C Gene

16,539,828 bp from pter
16,539,911 bp from pter
84 bases
Plus strand

Genomic View for MIRLET7C Gene

Genes around MIRLET7C on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MIRLET7C Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIRLET7C Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIRLET7C Gene

Proteins for MIRLET7C Gene

Post-translational modifications for MIRLET7C Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIRLET7C Gene

Domains & Families for MIRLET7C Gene

Gene Families for MIRLET7C Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with MIRLET7C: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for MIRLET7C Gene

Function for MIRLET7C Gene

Animal Model Products

miRNA Products

Clone Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIRLET7C Gene

Localization for MIRLET7C Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS and Gene Ontology (GO) - Cellular Components for MIRLET7C Gene

Pathways & Interactions for MIRLET7C Gene

SuperPathways for MIRLET7C Gene

SuperPathway Contained pathways
1 MicroRNAs in cancer
genes like me logo Genes that share pathways with MIRLET7C: view

Pathways by source for MIRLET7C Gene

1 KEGG pathway for MIRLET7C Gene

Interacting Proteins for MIRLET7C Gene

Gene Ontology (GO) - Biological Process for MIRLET7C Gene


No data available for SIGNOR curated interactions for MIRLET7C Gene

Transcripts for MIRLET7C Gene


(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Alternative Splicing Database (ASD) splice patterns (SP) for MIRLET7C Gene

No ASD Table

Relevant External Links for MIRLET7C Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for MIRLET7C Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for MIRLET7C Gene

NURSA nuclear receptor signaling pathways regulating expression of MIRLET7C Gene:

genes like me logo Genes that share expression patterns with MIRLET7C: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners and mRNA Expression by UniProt/SwissProt for MIRLET7C Gene

Orthologs for MIRLET7C Gene

This gene was present in the common ancestor of chordates.

Orthologs for MIRLET7C Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia bta-let-7c 35
  • 100 (a)
(Canis familiaris)
Mammalia cfa-let-7c 35
  • 100 (a)
(Pan troglodytes)
Mammalia ptr-let-7c 35
  • 100 (a)
(Ornithorhynchus anatinus)
Mammalia oan-let-7c-2 35 35
  • 76 (a)
(Mus musculus)
Mammalia Mirlet7c-1 35
  • 70 (a)
(Gallus gallus)
Aves gga-let-7c 35
  • 70 (a)
(Anolis carolinensis)
Reptilia aca-let-7c-1 35
  • 100 (a)
(Danio rerio)
Actinopterygii dre-let-7c-1 35
  • 64 (a)
sea squirt
(Ciona savignyi)
Ascidiacea csa-let-7c-1 35
  • 46 (a)
Species where no ortholog for MIRLET7C was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for MIRLET7C Gene

Gene Tree for MIRLET7C (if available)
Gene Tree for MIRLET7C (if available)

Paralogs for MIRLET7C Gene

No data available for Paralogs for MIRLET7C Gene

Variants for MIRLET7C Gene

Sequence variations from dbSNP and Humsavar for MIRLET7C Gene

SNP ID Clin Chr 21 pos Sequence Context AA Info Type
rs10470097 -- 16,538,872(+) AGTTC(A/G)TGAAA intron-variant, upstream-variant-2KB
rs111846070 -- 16,538,131(+) TTAGG(A/G)AATGC intron-variant, upstream-variant-2KB
rs112782413 -- 16,539,314(+) ACAAG(G/T)CAGGC intron-variant, downstream-variant-500B, upstream-variant-2KB
rs116171069 -- 16,540,309(+) ATTTG(A/C)GTTTT intron-variant, downstream-variant-500B
rs116792352 -- 16,538,217(+) AAAAA(C/T)GTGTA intron-variant, upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for MIRLET7C Gene

Variant ID Type Subtype PubMed ID
esv2723192 CNV deletion 23290073
esv3893374 CNV loss 25118596

Relevant External Links for MIRLET7C Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Variation tolerance for MIRLET7C Gene

Disorders for MIRLET7C Gene

Relevant External Links for MIRLET7C

Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for MIRLET7C Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MIRLET7C Gene

Publications for MIRLET7C Gene

  1. Let-7c down-regulation in Helicobacter pylori-related gastric carcinogenesis. (PMID: 26701848) Fassan M. … Rugge M. (Oncotarget 2016) 3 64
  2. Combinations of serum prostate-specific antigen and plasma expression levels of let-7c, miR-30c, miR-141, and miR-375 as potential better diagnostic biomarkers for prostate cancer. (PMID: 25521481) Kachakova D. … Kaneva R. (DNA Cell Biol. 2015) 3 64
  3. let-7b and let-7c are determinants of intrinsic chemoresistance in renal cell carcinoma. (PMID: 25951903) Peng J. … Fan J. (World J Surg Oncol 2015) 3 64
  4. Let-7c is a Candidate Biomarker for Cervical Intraepithelial Lesions: A Pilot Study. (PMID: 26063583) Malta M. … Sousa H. (Mol Diagn Ther 2015) 3 64
  5. Elevated serum microRNA Let-7c in Moyamoya disease. (PMID: 26070522) Zhao S. … Jia Y. (J. Stroke Cerebrovasc. Dis. 2015) 3 64

Products for MIRLET7C Gene

Sources for MIRLET7C Gene

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