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Aliases for MIRLET7C Gene

Subcategory (RNA class) for MIRLET7C Gene

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Quality Score for this RNA gene is

3

Aliases for MIRLET7C Gene

  • MicroRNA Let-7c 2 3
  • MIRNLET7C 3 6
  • LET7C 3 6
  • Hsa-Let-7c 3
  • Let-7c 3

External Ids for MIRLET7C Gene

ORGUL Members for MIRLET7C Gene

Previous Symbols for MIRLET7C Gene

  • MIRNLET7C

Summaries for MIRLET7C Gene

Entrez Gene Summary for MIRLET7C Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIRLET7C Gene

MIRLET7C (MicroRNA Let-7c) is a RNA Gene, and belongs to undefined RNA class. Among its related pathways are MicroRNAs in cancer.

No data available for UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MIRLET7C Gene

Genomics for MIRLET7C Gene

Genomic Location for MIRLET7C Gene

Start:
16,539,823 bp from pter
End:
16,539,916 bp from pter
Size:
94 bases
Orientation:
Plus strand

Genomic View for MIRLET7C Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for MIRLET7C Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIRLET7C Gene

No data available for Regulatory Elements for MIRLET7C Gene

Proteins for MIRLET7C Gene

Post-translational modifications for MIRLET7C Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIRLET7C Gene

Domains for MIRLET7C Gene

Gene Families for MIRLET7C Gene

HGNC:
  • MIR :ncRNAs / Micro RNAs
genes like me logo Genes that share domains with MIRLET7C: view

No data available for Protein Domains and UniProtKB/Swiss-Prot for MIRLET7C Gene

Function for MIRLET7C Gene

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for MIRLET7C Gene

Localization for MIRLET7C Gene

No data available for Gene Ontology (GO) - Cellular Components for MIRLET7C Gene

Pathways for MIRLET7C Gene

SuperPathways for MIRLET7C Gene

Superpath Contained pathways
1 MicroRNAs in cancer
genes like me logo Genes that share pathways with MIRLET7C: view

Pathways by source for MIRLET7C Gene

1 KEGG pathway for MIRLET7C Gene

Interacting Proteins for MIRLET7C Gene

Gene Ontology (GO) - Biological Process for MIRLET7C Gene

None

Transcripts for MIRLET7C Gene

mRNA/cDNA for MIRLET7C Gene

(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Alternative Splicing Database (ASD) splice patterns (SP) for MIRLET7C Gene

No ASD Table

Relevant External Links for MIRLET7C Gene

GeneLoc Exon Structure for
MIRLET7C
ECgene alternative splicing isoforms for
MIRLET7C

Expression for MIRLET7C Gene

mRNA expression in normal human tissues for MIRLET7C Gene

genes like me logo Genes that share expressions with MIRLET7C: view

Orthologs for MIRLET7C Gene

This gene was present in the common ancestor of chordates.

Orthologs for MIRLET7C Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ptr-let-7c 37
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia bta-let-7c 37
  • 100 (a)
OneToOne
dog
(Canis familiaris)
Mammalia cfa-let-7c 37
  • 100 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Mirlet7c-1 37
  • 70 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia oan-let-7c-2 37
  • 76 (a)
OneToMany
oan-let-7c-2 37
  • 76 (a)
OneToMany
chicken
(Gallus gallus)
Aves gga-let-7c 37
  • 70 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia aca-let-7c-1 37
  • 100 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii dre-let-7c-1 37
  • 64 (a)
OneToOne
sea squirt
(Ciona savignyi)
Ascidiacea csa-let-7c-1 37
  • 46 (a)
OneToMany
Species with no ortholog for MIRLET7C:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for MIRLET7C Gene

ENSEMBL:
Gene Tree for MIRLET7C (if available)
TreeFam:
Gene Tree for MIRLET7C (if available)

Paralogs for MIRLET7C Gene

No data available for Paralogs for MIRLET7C Gene

Variants for MIRLET7C Gene

Structural Variations from Database of Genomic Variants (DGV) for MIRLET7C Gene

Variant ID Type Subtype PubMed ID
esv2723192 CNV Deletion 23290073

Relevant External Links for MIRLET7C Gene

HapMap Linkage Disequilibrium report
MIRLET7C

No data available for Sequence variations from dbSNP and Humsavar for MIRLET7C Gene

Disorders for MIRLET7C Gene

No disorders were found for MIRLET7C Gene.

No data available for UniProtKB/Swiss-Prot for MIRLET7C Gene

Publications for MIRLET7C Gene

  1. Homozygous deletion scanning of the lung cancer genome at a 100-kb resolution. (PMID: 17674361) Nagayama K. … Yokota J. (Genes Chromosomes Cancer 2007) 23
  2. Identification of novel genes coding for small expressed RNAs. (PMID: 11679670) Lagos-Quintana M. … Tuschl T. (Science 2001) 3
  3. Reduced accumulation of specific microRNAs in colorectal neoplasia. (PMID: 14573789) Michael M.Z. … James R.J. (Mol. Cancer Res. 2003) 3
  4. miRBase: microRNA sequences, targets and gene nomenclature. (PMID: 16381832) Griffiths-Jones S. … Enright A.J. (Nucleic Acids Res. 2006) 3
  5. The tumor suppressor microRNA let-7 represses the HMGA2 oncogene. (PMID: 17437991) Lee Y.S. … Dutta A. (Genes Dev. 2007) 3

Products for MIRLET7C Gene

Sources for MIRLET7C Gene

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