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Aliases for MIRLET7C Gene

Subcategory (RNA class) for MIRLET7C Gene


Quality Score for this RNA gene is


Aliases for MIRLET7C Gene

  • MicroRNA Let-7c 2 3
  • MIRNLET7C 3 6
  • LET7C 3 6
  • Hsa-Let-7c 3
  • Let-7c 3

External Ids for MIRLET7C Gene

ORGUL Members for MIRLET7C Gene

Previous HGNC Symbols for MIRLET7C Gene


Previous GeneCards Identifiers for MIRLET7C Gene

  • GC21P016842
  • GC21P017912

Summaries for MIRLET7C Gene

Entrez Gene Summary for MIRLET7C Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIRLET7C Gene

MIRLET7C (MicroRNA Let-7c) is an RNA Gene, and is affiliated with the undefined RNA class. Among its related pathways are MicroRNAs in cancer.

No data available for UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MIRLET7C Gene

Genomics for MIRLET7C Gene

Genomic Location for MIRLET7C Gene

16,539,823 bp from pter
16,539,916 bp from pter
94 bases
Plus strand

Genomic View for MIRLET7C Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for MIRLET7C Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIRLET7C Gene

No data available for Regulatory Elements for MIRLET7C Gene

Proteins for MIRLET7C Gene

Post-translational modifications for MIRLET7C Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIRLET7C Gene

Domains for MIRLET7C Gene

Gene Families for MIRLET7C Gene

  • MIR :ncRNAs / Micro RNAs

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with MIRLET7C: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for MIRLET7C Gene

Function for MIRLET7C Gene

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for MIRLET7C Gene

Localization for MIRLET7C Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS and Gene Ontology (GO) - Cellular Components for MIRLET7C Gene

Pathways for MIRLET7C Gene

SuperPathways for MIRLET7C Gene

Superpath Contained pathways
1 MicroRNAs in cancer
genes like me logo Genes that share pathways with MIRLET7C: view

Pathways by source for MIRLET7C Gene

1 KEGG pathway for MIRLET7C Gene

Interacting Proteins for MIRLET7C Gene

Gene Ontology (GO) - Biological Process for MIRLET7C Gene


Transcripts for MIRLET7C Gene


(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Alternative Splicing Database (ASD) splice patterns (SP) for MIRLET7C Gene

No ASD Table

Relevant External Links for MIRLET7C Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for MIRLET7C Gene

mRNA expression in normal human tissues for MIRLET7C Gene

genes like me logo Genes that share expressions with MIRLET7C: view

In Situ Assay Products

No data available for mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , mRNA Expression by UniProt/SwissProt and Expression partners for MIRLET7C Gene

Orthologs for MIRLET7C Gene

This gene was present in the common ancestor of chordates.

Orthologs for MIRLET7C Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia bta-let-7c 36
  • 100 (a)
(Canis familiaris)
Mammalia cfa-let-7c 36
  • 100 (a)
(Mus musculus)
Mammalia Mirlet7c-1 36
  • 70 (a)
(Ornithorhynchus anatinus)
Mammalia oan-let-7c-2 36
  • 76 (a)
oan-let-7c-2 36
  • 76 (a)
(Pan troglodytes)
Mammalia ptr-let-7c 36
  • 100 (a)
(Gallus gallus)
Aves gga-let-7c 36
  • 70 (a)
(Anolis carolinensis)
Reptilia aca-let-7c-1 36
  • 100 (a)
(Danio rerio)
Actinopterygii dre-let-7c-1 36
  • 64 (a)
sea squirt
(Ciona savignyi)
Ascidiacea csa-let-7c-1 36
  • 46 (a)
Species with no ortholog for MIRLET7C:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for MIRLET7C Gene

Gene Tree for MIRLET7C (if available)
Gene Tree for MIRLET7C (if available)

Paralogs for MIRLET7C Gene

No data available for Paralogs for MIRLET7C Gene

Variants for MIRLET7C Gene

Structural Variations from Database of Genomic Variants (DGV) for MIRLET7C Gene

Variant ID Type Subtype PubMed ID
esv2723192 CNV Deletion 23290073

Relevant External Links for MIRLET7C Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Sequence variations from dbSNP and Humsavar for MIRLET7C Gene

Disorders for MIRLET7C Gene

No disorders were found for MIRLET7C Gene.

No data available for MalaCards , OMIM , UniProtKB/Swiss-Prot , University of Copenhagen DISEASES , Novoseek inferred disease relationships , Genatlas and External Links for MIRLET7C Gene

Publications for MIRLET7C Gene

  1. Homozygous deletion scanning of the lung cancer genome at a 100-kb resolution. (PMID: 17674361) Nagayama K. … Yokota J. (Genes Chromosomes Cancer 2007) 23
  2. Identification of novel genes coding for small expressed RNAs. (PMID: 11679670) Lagos-Quintana M. … Tuschl T. (Science 2001) 3
  3. Reduced accumulation of specific microRNAs in colorectal neoplasia. (PMID: 14573789) Michael M.Z. … James R.J. (Mol. Cancer Res. 2003) 3
  4. miRBase: microRNA sequences, targets and gene nomenclature. (PMID: 16381832) Griffiths-Jones S. … Enright A.J. (Nucleic Acids Res. 2006) 3
  5. The tumor suppressor microRNA let-7 represses the HMGA2 oncogene. (PMID: 17437991) Lee Y.S. … Dutta A. (Genes Dev. 2007) 3

Products for MIRLET7C Gene

Sources for MIRLET7C Gene

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