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MIRLET7BHG Gene

RNA gene   GIFtS: 27
GCID: GC22P046482

MIRLET7B Host Gene (Non-Protein Coding)

  Search for MIRLET7BHG
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Subcategory (RNA class): miRNA

Quality score for this RNA gene is 3

Aliases
MIRLET7B Host Gene (Non-Protein Coding)1 2
linc-Ppara2
FLJ273654
CDNA FLJ27365 Fis, Clone UBA026334
Novel Transcript4
Uncharacterized Protein4

External Ids:    HGNC: 371891   Entrez Gene: 4009312   Ensembl: ENSG000001971827   UniProtKB: Q6ZNQ04   UniProtKB: B1AKH74   
UniProtKB: G3XAK84   UniProtKB: B1AKH84   

Export aliases for MIRLET7BHG gene to outside databases

Previous GC identifer: GC00U927125


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for MIRLET7BHG Gene:
MIRLET7BHG (MIRLET7B host gene (non-protein coding)) is an RNA gene, and is affiliated with the miRNA class.


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000022.11  NC_018933.2  NT_011520.13  
Regulatory elements:
   Search for regulatory transcription factor binding sites for MIRLET7BHG
         Other transcription factors

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Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat MIRLET7BHG


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 22q13.31   Ensembl cytogenetic band:  22q13.31   HGNC cytogenetic band: 22q13.31

MIRLET7BHG Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
MIRLET7BHG gene location

GeneLoc information about chromosome 22         GeneLoc Exon Structure

GeneLoc location for GC22P046482:  view genomic region     (about GC identifiers)

Start:
46,449,749 bp from pter      End:
46,509,808 bp from pter
Size:
60,060 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/TrEMBL: Q6ZNQ0 (See protein sequence)
Recommended Name: Novel transcript  
Size: 160 amino acids; 17405 Da

UniProtKB/TrEMBL: B1AKH7 (See protein sequence)

Recommended Name: FLJ27365 protein, isoform CRA_a  
Size: 219 amino acids; 23653 Da

UniProtKB/TrEMBL: G3XAK8 (See protein sequence)

Recommended Name: FLJ27365 protein, isoform CRA_b  
Size: 74 amino acids; 8376 Da

UniProtKB/TrEMBL: B1AKH8 (See protein sequence)

Recommended Name: Novel transcript  
Size: 49 amino acids; 5413 Da

Explore proteomics data for MIRLET7BHG at MOPED


See MIRLET7BHG Protein Expression from SPIRE MOPED, PaxDB, and MaxQB


ENSEMBL proteins: 
 ENSP00000370439   ENSP00000410936   ENSP00000416704   ENSP00000353966  

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(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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HGNC Gene Families:
LNCRNA: Long non-coding RNAs

ProtoNet protein and cluster: Q6ZNQ0


(According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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Animal Models:
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(According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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(SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for MIRLET7BHG
Interactions:

    Search GeneGlobe Interaction Network for MIRLET7BHG

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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Browse Tocris compounds for MIRLET7BHG



(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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REFSEQ mRNAs for MIRLET7BHG gene: 
NM_207477.1  

Unigene Cluster for MIRLET7BHG:

MIRLET7B host gene (non-protein coding)
Hs.235838  [show with all ESTs]
Unigene Representative Sequence: AK127117
4 Ensembl transcripts including schematic representations, and UCSC links where relevant:
ENST00000381051(uc003bgr.4) ENST00000443490 ENST00000435439 ENST00000360737(uc003bgu.2 uc003bgt.4)

miRNA
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Additional mRNA sequence: 

AK023424.1 AK127117.1 AK130875.1 NR_027033.1 

5 DOTS entries:

DT.100726993  DT.97775268  DT.425944  DT.95257067  DT.40236411 

Selected AceView cDNA sequences (see all 41):

NM_207477 H55320 BQ890633 AA603041 CK820910 BF436480 BM701741 BF933010 
AK130875 AA758934 BF344234 AK023424 BC036832 AA775983 AI300535 AJ572271 
BQ711270 BF003052 F15682 F18236 AI457175 BE876698 BQ895974 BM666595 

GeneLoc Exon Structure


(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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Expression evidence for MIRLET7BHG:none

MIRLET7BHG expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>2/3
CGAP TAG: GCAAAATCCC
MIRLET7BHG Expression
About this image

MIRLET7BHG Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

MIRLET7BHG Protein Expression

SOURCE GeneReport for Unigene cluster: Hs.235838
    Custom PCR Arrays for MIRLET7BHG
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In Situ
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(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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This gene was present in the common ancestor of human and chimp.

Orthologs for MIRLET7BHG gene from 1 species (see representative species )    About this table
Organism Taxonomic
classification
Gene Description Human
Similarity
Orthology
Type
Details
chimpanzee
(Pan troglodytes)
Mammalia --
Uncharacterized protein
96(a)
1 ↔ 1
22(44898280-44922519)


ENSEMBL Gene Tree for MIRLET7BHG (if available)
TreeFam Gene Tree for MIRLET7BHG (if available)

(Paralogs according to 1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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(SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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Selected SNPs for MIRLET7BHG (see all 569)    About this table    
Genomic DataTranscription Related DataAllele Frequencies
SNP IDValidClinical
significance
Chr 22 posSequence#AA
Chg
TypeMore#Allele
freq
PopTotal
sample
More
----------
rs1930880201,2
--46479913(+) AGGAAC/TATGGC 1 -- us2k10--------
rs1421987981,2
--46480008(+) GGCGAC/TGGTGG 1 -- us2k10--------
rs1858819531,2
--46480234(+) AACACA/GTGGAA 1 -- us2k10--------
rs734567041,2
C,F--46480250(+) GGTTCA/GTGGTG 1 -- us2k13Minor allele frequency- G:0.08WA CSA 122
rs1385549561,2
C--46480357(+) AGCAGC/TGAACC 1 -- us2k10--------
rs1864627021,2
--46480365(+) ACCTCC/TGAGAG 1 -- us2k10--------
rs745377081,2
C,F--46480480(+) GACGCG/ATGTTG 1 -- us2k11Minor allele frequency- A:0.03NA 120
rs1434226501,2
--46480510(+) GCCCCA/GGGTGT 1 -- us2k10--------
rs1479878561,2
--46480570(+) TGCACA/GTGTGC 1 -- us2k10--------
rs96160841,2
C,F,H--46480602(+) CATTGC/TGTGAG 1 -- us2k122Minor allele frequency- T:0.16NS EA NA WA 2594

HapMap Linkage Disequilibrium report for MIRLET7BHG (46449749 - 46509808 bp)

Structural Variations
     Database of Genomic Variants (DGV) Selected variations for MIRLET7BHG (see all 28):    About this table    
Variant IDTypeSubtypePubMed ID
esv1011338CNV Deletion20482838
esv2661950CNV Deletion23128226
esv2724423CNV Deletion23290073
esv271386CNV Insertion20981092
esv1346561CNV Insertion17803354
dgv5008n71CNV Loss21882294
nsv915340CNV Loss21882294
nsv915336CNV Loss21882294
dgv5009n71CNV Loss21882294
nsv459905CNV Loss19166990

Site Specific Mutation Identification with PCR Assays
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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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(in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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PubMed articles for MIRLET7BHG gene integrated from 10 sources:
(articles sorted by number of sources associating them with MIRLET7BHG)
    Utopia: connect your pdf to the dynamic
world of online information

  1. Multiple knockout mouse models reveal lincRNAs are required for life and brain development. (PubMed id 24381249)1, 3 Sauvageau M....Rinn J.L. (Elife 2013)
  2. Cytoplasmic sequestration of HDAC7 from mitochondrial and nuclear compartments upon initiation of apoptosis. (PubMed id 15364908)1, 3 Bakin R.E. and Jung M.O. (J. Biol. Chem. 2004)
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1 Ota T.... Sugano S. (Nat. Genet. 2004)
  4. Normalization and subtraction: two approaches to facilitate gene discovery. (PubMed id 8889548)1 Bonaldo M.F.... Soares M.B. (Genome Res. 1996)

(in PubMed, OMIM, and NCBI Bookshelf)
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 ANDOR
Aliases
Free Text  

  Query String
PubMed
OMIM
NCBI Bookshelf
  (Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 400931 HGNC: 37189 AceView: FLJ27365 Ensembl:ENSG00000197182 euGenes: HUgn400931
ECgene: MIRLET7BHG H-InvDB: MIRLET7BHG

(According to HUGE)
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(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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NameDescription
PharmGKB entry for MIRLET7BHG Pharmacogenomics, SNPs, Pathways

(Patent information from GeneIP,
Licensable technologies from WIS Yeda, Salk, Tufts,
IP news from LifeMap Sciences, Inc.)
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Patent Information for MIRLET7BHG gene:
Search GeneIP for patents involving MIRLET7BHG

GeneCards and IP:
Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
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