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Aliases for MIRLET7B Gene

Subcategory (RNA class) for MIRLET7B Gene

miRNA

Quality Score for this RNA gene is

3

Aliases for MIRLET7B Gene

  • MicroRNA Let-7b 2 3 5
  • Hsa-Let-7b 3
  • MIRNLET7B 3
  • Let-7b 3
  • LET7B 3

External Ids for MIRLET7B Gene

ORGUL Members for MIRLET7B Gene

Previous HGNC Symbols for MIRLET7B Gene

  • MIRNLET7B

Previous GeneCards Identifiers for MIRLET7B Gene

  • GC22P044889
  • GC22P046509
  • GC22P046114
  • GC22P046115
  • GC22P046116
  • GC22P046056

Summaries for MIRLET7B Gene

Entrez Gene Summary for MIRLET7B Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIRLET7B Gene

MIRLET7B (MicroRNA Let-7b) is an RNA Gene, and is affiliated with the miRNA class. Among its related pathways are Metastatic brain tumor and MicroRNAs in cancer.

No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MIRLET7B Gene

Genomics for MIRLET7B Gene

Genomic Location for MIRLET7B Gene

Chromosome:
22
Start:
46,113,686 bp from pter
End:
46,113,768 bp from pter
Size:
83 bases
Orientation:
Plus strand

Genomic View for MIRLET7B Gene

Genes around MIRLET7B on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MIRLET7B Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIRLET7B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIRLET7B Gene

No data available for Regulatory Elements for MIRLET7B Gene

Proteins for MIRLET7B Gene

Post-translational modifications for MIRLET7B Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIRLET7B Gene

Domains & Families for MIRLET7B Gene

Gene Families for MIRLET7B Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with MIRLET7B: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for MIRLET7B Gene

Function for MIRLET7B Gene

Animal Model Products

miRNA Products

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIRLET7B Gene

Localization for MIRLET7B Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS and Gene Ontology (GO) - Cellular Components for MIRLET7B Gene

Pathways & Interactions for MIRLET7B Gene

genes like me logo Genes that share pathways with MIRLET7B: view

Pathways by source for MIRLET7B Gene

1 BioSystems pathway for MIRLET7B Gene
1 KEGG pathway for MIRLET7B Gene

Interacting Proteins for MIRLET7B Gene

Gene Ontology (GO) - Biological Process for MIRLET7B Gene

None

No data available for SIGNOR curated interactions for MIRLET7B Gene

Drugs & Compounds for MIRLET7B Gene

No Compound Related Data Available

Transcripts for MIRLET7B Gene

mRNA/cDNA for MIRLET7B Gene

(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

miRNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for MIRLET7B Gene

No ASD Table

Relevant External Links for MIRLET7B Gene

GeneLoc Exon Structure for
MIRLET7B
ECgene alternative splicing isoforms for
MIRLET7B

Expression for MIRLET7B Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for MIRLET7B Gene

NURSA nuclear receptor signaling pathways regulating expression of MIRLET7B Gene:

MIRLET7B
genes like me logo Genes that share expression patterns with MIRLET7B: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for MIRLET7B Gene

Orthologs for MIRLET7B Gene

Evolution for MIRLET7B Gene

ENSEMBL:
Gene Tree for MIRLET7B (if available)
TreeFam:
Gene Tree for MIRLET7B (if available)

No data available for Orthologs for MIRLET7B Gene

Paralogs for MIRLET7B Gene

No data available for Paralogs for MIRLET7B Gene

Variants for MIRLET7B Gene

Sequence variations from dbSNP and Humsavar for MIRLET7B Gene

SNP ID Clin Chr 22 pos Sequence Context AA Info Type
rs1001370205 -- 46,112,517(+) TTTCC(A/T)GCAGG nc-transcript-variant, upstream-variant-2KB
rs1001637152 -- 46,112,860(+) GTCTG(A/G)AACCC nc-transcript-variant, downstream-variant-500B, upstream-variant-2KB
rs1001883421 -- 46,112,293(+) GGAGG(A/G)GGCCG nc-transcript-variant, upstream-variant-2KB
rs1001900208 -- 46,112,270(+) TTCTG(A/G)TGGCG nc-transcript-variant, upstream-variant-2KB
rs1003823902 -- 46,113,267(+) GTGGC(C/T)GAGAC nc-transcript-variant, downstream-variant-500B, upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for MIRLET7B Gene

Variant ID Type Subtype PubMed ID
dgv2469n106 OTHER inversion 24896259
nsv1152661 OTHER inversion 26484159
nsv459905 CNV loss 19166990
nsv471212 CNV loss 18288195
nsv471213 CNV gain 18288195
nsv516279 CNV loss 19592680
nsv829281 CNV gain 20364138
nsv829285 CNV gain 20364138
nsv834224 CNV loss 17160897

Relevant External Links for MIRLET7B Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MIRLET7B

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Variation tolerance for MIRLET7B Gene

Disorders for MIRLET7B Gene

Relevant External Links for MIRLET7B

Genetic Association Database (GAD)
MIRLET7B
Human Genome Epidemiology (HuGE) Navigator
MIRLET7B
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
MIRLET7B

No disorders were found for MIRLET7B Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MIRLET7B Gene

Publications for MIRLET7B Gene

  1. Let-7b inhibits the malignant behavior of glioma cells and glioma stem-like cells via downregulation of E2F2. (PMID: 27520092) Song H. … Yuan L. (J. Physiol. Biochem. 2016) 3 64
  2. High DRC Levels Are Associated with Let-7b Overexpression in Women with Breast Cancer. (PMID: 27271599) EncarnaciA^n J. … Matta J.L. (Int J Mol Sci 2016) 3 64
  3. Downregulation of let-7b promotes COL1A1 and COL1A2 expression in dermis and skin fibroblasts during heat wound repair. (PMID: 26861712) Liu J. … Zhou J. (Mol Med Rep 2016) 3 64
  4. In a retrospective international study, circulating miR-148b and let-7b were found to be serum markers for detecting primary IgA nephropathy. (PMID: 26581012) Serino G. … Schena F.P. (Kidney Int. 2016) 3 64
  5. Let-7b overexpression leads to increased radiosensitivity of uveal melanoma cells. (PMID: 25588203) Zhou Y. … Fan X. (Melanoma Res. 2015) 3 64

Products for MIRLET7B Gene

Sources for MIRLET7B Gene

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