Free for academic non-profit institutions. Other users need a Commercial license

Aliases for MIRLET7B Gene

Subcategory (RNA class) for MIRLET7B Gene

miRNA

Quality Score for this RNA gene is

3

Aliases for MIRLET7B Gene

  • MicroRNA Let-7b 2 3 5
  • Hsa-Let-7b 3
  • MIRNLET7B 3
  • Let-7b 3
  • LET7B 3

External Ids for MIRLET7B Gene

ORGUL Members for MIRLET7B Gene

Previous HGNC Symbols for MIRLET7B Gene

  • MIRNLET7B

Previous GeneCards Identifiers for MIRLET7B Gene

  • GC22P044889
  • GC22P046509
  • GC22P046114
  • GC22P046115
  • GC22P046116
  • GC22P046056
  • GC22P046117
  • GC22P046118

Summaries for MIRLET7B Gene

Entrez Gene Summary for MIRLET7B Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIRLET7B Gene

MIRLET7B (MicroRNA Let-7b) is an RNA Gene, and is affiliated with the miRNA class. Among its related pathways are MicroRNAs in cancer and Metastatic brain tumor.

Additional gene information for MIRLET7B Gene

No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MIRLET7B Gene

Genomics for MIRLET7B Gene

GeneHancer (GH) Regulatory Elements for MIRLET7B Gene

Promoters and enhancers for MIRLET7B Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH22I046111 Enhancer 1.3 Ensembl ENCODE dbSUPER 550.8 +0.8 775 5.5 ZNF2 IRF4 ZNF121 GLIS2 ZNF213 ARID2 ZNF143 SP3 RXRA REST MIR4763 MIRLET7A3 MIRLET7B GC22P046122 GC22P046121 GC22P046120 GC22M046113 GC22M046089 PPARA MIRLET7BHG
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around MIRLET7B on UCSC Golden Path with GeneCards custom track

Genomic Locations for MIRLET7B Gene

Genomic Locations for MIRLET7B Gene
chr22:46,113,686-46,113,768
(GRCh38/hg38)
Size:
83 bases
Orientation:
Plus strand
chr22:46,509,566-46,509,648
(GRCh37/hg19)

Genomic View for MIRLET7B Gene

Genes around MIRLET7B on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MIRLET7B Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIRLET7B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIRLET7B Gene

Proteins for MIRLET7B Gene

Post-translational modifications for MIRLET7B Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIRLET7B Gene

Domains & Families for MIRLET7B Gene

Gene Families for MIRLET7B Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with MIRLET7B: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for MIRLET7B Gene

Function for MIRLET7B Gene

Gene Ontology (GO) - Molecular Function for MIRLET7B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:1903231 mRNA binding involved in posttranscriptional gene silencing IDA 15131085
genes like me logo Genes that share ontologies with MIRLET7B: view

Animal Model Products

miRNA Products

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIRLET7B Gene

Localization for MIRLET7B Gene

Gene Ontology (GO) - Cellular Components for MIRLET7B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005615 extracellular space IDA 26646931
GO:0070062 extracellular exosome IDA 28159509
genes like me logo Genes that share ontologies with MIRLET7B: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS and Subcellular locations from the Human Protein Atlas (HPA) for MIRLET7B Gene

Pathways & Interactions for MIRLET7B Gene

genes like me logo Genes that share pathways with MIRLET7B: view

Pathways by source for MIRLET7B Gene

1 BioSystems pathway for MIRLET7B Gene
1 KEGG pathway for MIRLET7B Gene

Interacting Proteins for MIRLET7B Gene

Gene Ontology (GO) - Biological Process for MIRLET7B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0010507 negative regulation of autophagy IDA 26296645
GO:0035195 gene silencing by miRNA IDA 15131085
GO:0043154 negative regulation of cysteine-type endopeptidase activity involved in apoptotic process IDA 26296645
GO:0045766 positive regulation of angiogenesis IDA 26296645
GO:0070301 cellular response to hydrogen peroxide IDA 26296645
genes like me logo Genes that share ontologies with MIRLET7B: view

No data available for SIGNOR curated interactions for MIRLET7B Gene

Drugs & Compounds for MIRLET7B Gene

No Compound Related Data Available

Transcripts for MIRLET7B Gene

mRNA/cDNA for MIRLET7B Gene

(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

miRNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for MIRLET7B Gene

No ASD Table

Relevant External Links for MIRLET7B Gene

GeneLoc Exon Structure for
MIRLET7B
ECgene alternative splicing isoforms for
MIRLET7B

Expression for MIRLET7B Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for MIRLET7B Gene

NURSA nuclear receptor signaling pathways regulating expression of MIRLET7B Gene:

MIRLET7B
genes like me logo Genes that share expression patterns with MIRLET7B: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for MIRLET7B Gene

Orthologs for MIRLET7B Gene

Evolution for MIRLET7B Gene

ENSEMBL:
Gene Tree for MIRLET7B (if available)
TreeFam:
Gene Tree for MIRLET7B (if available)

No data available for Orthologs for MIRLET7B Gene

Paralogs for MIRLET7B Gene

No data available for Paralogs for MIRLET7B Gene

Variants for MIRLET7B Gene

Sequence variations from dbSNP and Humsavar for MIRLET7B Gene

SNP ID Clin Chr 22 pos Variation AA Info Type
rs1001370205 -- 46,112,517(+) T/A upstream_transcript_variant
rs1001637152 -- 46,112,860(+) G/A upstream_transcript_variant
rs1001883421 -- 46,112,293(+) G/A upstream_transcript_variant
rs1001900208 -- 46,112,270(+) G/A upstream_transcript_variant
rs1003823902 -- 46,113,267(+) C/T upstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for MIRLET7B Gene

Variant ID Type Subtype PubMed ID
dgv2469n106 OTHER inversion 24896259
nsv1152661 OTHER inversion 26484159
nsv459905 CNV loss 19166990
nsv471212 CNV loss 18288195
nsv471213 CNV gain 18288195
nsv516279 CNV loss 19592680
nsv829281 CNV gain 20364138
nsv829285 CNV gain 20364138
nsv834224 CNV loss 17160897

Additional Variant Information for MIRLET7B Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MIRLET7B

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Variation tolerance for MIRLET7B Gene

Disorders for MIRLET7B Gene

Additional Disease Information for MIRLET7B

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology

No disorders were found for MIRLET7B Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MIRLET7B Gene

Publications for MIRLET7B Gene

  1. Cerebrospinal fluid CD4+ T lymphocyte-derived miRNA-let-7b can enhances the diagnostic performance of Alzheimer's disease biomarkers. (PMID: 29170128) Liu Y … Wang T (Biochemical and biophysical research communications 2018) 3 58
  2. Detection of let-7 miRNAs in urine supernatant as potential diagnostic approach in non-metastatic clear-cell renal cell carcinoma. (PMID: 28694731) Fedorko M … Slaby O (Biochemia medica 2017) 3 58
  3. Roles of microRNA let-7b in papillary thyroid carcinoma by regulating HMGA2. (PMID: 29025376) Li H … Su Z (Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine 2017) 3 58
  4. Let7b modulates the Wnt/β-catenin pathway in liver cancer cells via downregulated Frizzled4. (PMID: 28671046) Cai H … Yuan Y (Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine 2017) 3 58
  5. let-7b and let-7c microRNAs promote histone H2B ubiquitylation and inhibit cell migration by targeting multiple components of the H2B deubiquitylation machinery. (PMID: 28604753) Spolverini A … Oren M (Oncogene 2017) 3 58

Products for MIRLET7B Gene

Sources for MIRLET7B Gene

Content
Loading form....