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Aliases for MIRLET7B Gene

Subcategory (RNA class) for MIRLET7B Gene

miRNA

Quality Score for this RNA gene is

3

Aliases for MIRLET7B Gene

  • MicroRNA Let-7b 2 3 5
  • Hsa-Let-7b 3
  • MIRNLET7B 3
  • Let-7b 3
  • LET7B 3

External Ids for MIRLET7B Gene

ORGUL Members for MIRLET7B Gene

Previous HGNC Symbols for MIRLET7B Gene

  • MIRNLET7B

Previous GeneCards Identifiers for MIRLET7B Gene

  • GC22P044889
  • GC22P046509
  • GC22P046114
  • GC22P046115

Summaries for MIRLET7B Gene

Entrez Gene Summary for MIRLET7B Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIRLET7B Gene

MIRLET7B (MicroRNA Let-7b) is an RNA Gene, and is affiliated with the miRNA class. Among its related pathways are MicroRNAs in cancer and miRNAs involved in DDR.

No data available for UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MIRLET7B Gene

Genomics for MIRLET7B Gene

Genomic Location for MIRLET7B Gene

Chromosome:
22
Start:
46,113,686 bp from pter
End:
46,113,768 bp from pter
Size:
83 bases
Orientation:
Plus strand

Genomic View for MIRLET7B Gene

Genes around MIRLET7B on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MIRLET7B Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIRLET7B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIRLET7B Gene

No data available for Regulatory Elements for MIRLET7B Gene

Proteins for MIRLET7B Gene

Post-translational modifications for MIRLET7B Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIRLET7B Gene

Domains & Families for MIRLET7B Gene

Gene Families for MIRLET7B Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with MIRLET7B: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for MIRLET7B Gene

Function for MIRLET7B Gene

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIRLET7B Gene

Localization for MIRLET7B Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS and Gene Ontology (GO) - Cellular Components for MIRLET7B Gene

Pathways & Interactions for MIRLET7B Gene

genes like me logo Genes that share pathways with MIRLET7B: view

Pathways by source for MIRLET7B Gene

2 BioSystems pathways for MIRLET7B Gene
1 KEGG pathway for MIRLET7B Gene

Interacting Proteins for MIRLET7B Gene

Gene Ontology (GO) - Biological Process for MIRLET7B Gene

None

No data available for SIGNOR curated interactions for MIRLET7B Gene

Drugs & Compounds for MIRLET7B Gene

No Compound Related Data Available

Transcripts for MIRLET7B Gene

mRNA/cDNA for MIRLET7B Gene

(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Alternative Splicing Database (ASD) splice patterns (SP) for MIRLET7B Gene

No ASD Table

Relevant External Links for MIRLET7B Gene

GeneLoc Exon Structure for
MIRLET7B
ECgene alternative splicing isoforms for
MIRLET7B

Expression for MIRLET7B Gene

mRNA expression in normal human tissues for MIRLET7B Gene

genes like me logo Genes that share expression patterns with MIRLET7B: view

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , mRNA Expression by UniProt/SwissProt and Protein tissue co-expression partners for MIRLET7B Gene

Orthologs for MIRLET7B Gene

This gene was present in the common ancestor of chordates.

Orthologs for MIRLET7B Gene

Organism Taxonomy Gene Similarity Type Details
oppossum
(Monodelphis domestica)
Mammalia mdo-let-7b 36
  • 85 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Mirlet7b 36
  • 92 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia oan-let-7b 36
  • 88 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia ptr-let-7b 36
  • 99 (a)
OneToOne
chicken
(Gallus gallus)
Aves gga-let-7b 36
  • 78 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia aca-let-7b 36
  • 76 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii CR354430.1 36
  • 80 (a)
OneToMany
dre-let-7b 36
  • 78 (a)
OneToMany
Species with no ortholog for MIRLET7B:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for MIRLET7B Gene

ENSEMBL:
Gene Tree for MIRLET7B (if available)
TreeFam:
Gene Tree for MIRLET7B (if available)

Paralogs for MIRLET7B Gene

No data available for Paralogs for MIRLET7B Gene

Variants for MIRLET7B Gene

Structural Variations from Database of Genomic Variants (DGV) for MIRLET7B Gene

Variant ID Type Subtype PubMed ID
dgv5004n71 CNV Loss 21882294
nsv829281 CNV Gain 20364138
dgv5006n71 CNV Loss 21882294
dgv5008n71 CNV Loss 21882294
nsv829285 CNV Gain 20364138
nsv471212 CNV Loss 18288195
dgv5009n71 CNV Loss 21882294
dgv5010n71 CNV Loss 21882294
nsv915336 CNV Loss 21882294
nsv471213 CNV Gain 18288195
nsv915337 CNV Loss 21882294
dgv5011n71 CNV Loss 21882294
nsv516279 CNV Loss 19592680
nsv915340 CNV Loss 21882294
dgv5012n71 CNV Loss 21882294
nsv915344 CNV Loss 21882294
nsv459905 CNV Loss 19166990
nsv834224 CNV Loss 17160897

Relevant External Links for MIRLET7B Gene

HapMap Linkage Disequilibrium report
MIRLET7B

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Sequence variations from dbSNP and Humsavar and Variation tolerance for MIRLET7B Gene

Disorders for MIRLET7B Gene

Relevant External Links for MIRLET7B

Genetic Association Database (GAD)
MIRLET7B
Human Genome Epidemiology (HuGE) Navigator
MIRLET7B
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
MIRLET7B

No disorders were found for MIRLET7B Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MIRLET7B Gene

Publications for MIRLET7B Gene

  1. Let-7b inhibits cell proliferation, migration, and invasion through targeting Cthrc1 in gastric cancer. (PMID: 25510669) Yu J. … Xu Z. (Tumour Biol. 2015) 3 67
  2. A combinatorial microRNA therapeutics approach to suppressing non-small cell lung cancer. (PMID: 25174400) Kasinski A.L. … Slack F.J. (Oncogene 2015) 3
  3. LncRNA-HOST2 regulates cell biological behaviors in epithelial ovarian cancer through a mechanism involving microRNA let-7b. (PMID: 25292198) Gao Y. … Hui N. (Hum. Mol. Genet. 2015) 3
  4. Let-7b binding site polymorphism in the B-cell lymphoma-extra large 3'UTR is associated with fluorouracil resistance of hepatocellular carcinoma. (PMID: 25333670) Ma J. … Lei X. (Mol Med Rep 2015) 3
  5. Over-expression of cofilin-1 suppressed growth and invasion of cancer cells is associated with up-regulation of let-7 microRNA. (PMID: 25597880) Tsai C.H. … Lee Y.J. (Biochim. Biophys. Acta 2015) 3

Products for MIRLET7B Gene

Sources for MIRLET7B Gene

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