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MIRLET7B Gene

RNA gene   GIFtS: 27
GCID: GC22P046509

MicroRNA Let-7b


(Previous symbol: MIRNLET7B)
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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Subcategory (RNA class): miRNA

Quality score for this RNA gene is 3

Aliases
MicroRNA Let-7b1 2
MIRNLET7B1 2 5
let-7b2 9
LET7B2 5
hsa-let-7b2

External Ids:    HGNC: 314791   Entrez Gene: 4068842   Ensembl: ENSG000002078757   OMIM: 6112495   
ORGUL members:    fRNAdb10:FR200750 FR152502      

Export aliases for MIRLET7B gene to outside databases

Previous GC identifer: GC22P044889


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for MIRLET7B Gene:
microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of
gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are
transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can
be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme
to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the
cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The
mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through
imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of
the target mRNA. The RefSeq represents the predicted microRNA stem-loop. (provided by RefSeq, Sep 2009)

GeneCards Summary for MIRLET7B Gene:
MIRLET7B (microRNA let-7b) is an RNA gene, and is affiliated with the miRNA class.




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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Regulatory elements:
   Search for regulatory transcription factor binding sites for MIRLET7B
         Other transcription factors

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Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat MIRLET7B


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 22q13.31   Ensembl cytogenetic band:  22q13.31   HGNC cytogenetic band: 22q13.31

MIRLET7B Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
MIRLET7B gene location

GeneLoc information about chromosome 22         GeneLoc Exon Structure

GeneLoc location for GC22P046509:  view genomic region (via miRBase)     (about GC identifiers)

Start:
46,509,566 bp from pter      End:
46,509,648 bp from pter
Size:
83 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB: --


(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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HGNC Gene Families:
MIR: ncRNAs / Micro RNAs

  --

(According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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Animal Models:
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(According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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  --

(SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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SuperPaths for MIRLET7B About    
See pathways by source

SuperPathContained pathways About
1miRNAs involved in DDR
miRNAs involved in DDR
2MicroRNAs in cardiomyocyte hypertrophy
MicroRNAs in cardiomyocyte hypertrophy
3MicroRNAs in cancer
MicroRNAs in cancer


Find genes that share SuperPaths with MIRLET7B           About GenesLikeMe

Pathways by source                                                                                                                                                                 See SuperPaths
Show all pathways


2 BioSystems Pathways for MIRLET7B
    MicroRNAs in cardiomyocyte hypertrophy
miRNAs involved in DDR


1 Kegg Pathway  (Kegg details for MIRLET7B):
    MicroRNAs in cancer

    Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for MIRLET7B
Interactions:

    Search GeneGlobe Interaction Network for MIRLET7B

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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Browse Small Molecules at EMD Millipore
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(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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1 Ensembl transcript including schematic representation, and UCSC links where relevant:
ENST00000385140(miRNA)
miRNA
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GeneLoc Exon Structure


(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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Expression evidence for MIRLET7B:none

See probesets specificity/sensitivity at GeneAnnot
CGAP TAG: --


MIRLET7B expression in embryonic tissues and stem cells    About this table
Data from LifeMap, the Embryonic Development and Stem Cells Database
 
 Endothelium (Cardiovascular System)    fully expand to see all 2 entries
         Peripheral blood-derived endothelial progenitor cells
MIRLET7B Protein expression data from MOPED1, PaxDb2 and MaxQB3 --
    Custom PCR Arrays for MIRLET7B
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(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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This gene was present in the common ancestor of chordates.

Orthologs for MIRLET7B gene from Selected species (see all 7)    About this table
Organism Taxonomic
classification
Gene Description Human
Similarity
Orthology
Type
Details
chicken
(Gallus gallus)
Aves gga-let-7b6
gga-let-7b
78(a)
1 ↔ 1
1(71371974-71372065) ENSGALG00000018241
lizard
(Anolis carolinensis)
Reptilia aca-let-7b6
aca-let-7b
76(a)
1 ↔ 1
5(83532327-83532417) ENSACAG00000018867
zebrafish
(Danio rerio)
Actinopterygii CR354430.16
dre-let-7b6
dre-let-7b
80(a)
78(a)
1 ↔ many
1 ↔ many
25(2133275-2133368) ENSDARG00000082399
4(17721332-17721425) ENSDARG00000081807
        Species with no ortholog for MIRLET7B

ENSEMBL Gene Tree for MIRLET7B (if available)
TreeFam Gene Tree for MIRLET7B (if available)

(Paralogs according to 1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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  --

(SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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Structural Variations
     Database of Genomic Variants (DGV) Selected variations for MIRLET7B (see all 18):    About this table    
Variant IDTypeSubtypePubMed ID
dgv5008n71CNV Loss21882294
nsv915340CNV Loss21882294
nsv915336CNV Loss21882294
dgv5009n71CNV Loss21882294
nsv459905CNV Loss19166990
nsv471212CNV Loss18288195
nsv915337CNV Loss21882294
nsv915344CNV Loss21882294
dgv5012n71CNV Loss21882294
nsv834224CNV Loss17160897

Site Specific Mutation Identification with PCR Assays
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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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OMIM gene information: 611249    OMIM disorders: --


Find genes that share disorders with MIRLET7B           About GenesLikeMe

Genetic Association Database (GAD): MIRLET7B
Human Genome Epidemiology (HuGE) Navigator: MIRLET7B (1 document)

Export disorders for MIRLET7B gene to outside databases

(in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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PubMed articles for MIRLET7B gene, integrated from 10 sources (see all 22):
(articles sorted by number of sources associating them with MIRLET7B)
    Utopia: connect your pdf to the dynamic
world of online information

  1. Let-7b is involved in the inflammation and immune responses associated with Helicobacter pylori infection by targeting Toll-like receptor 4. (PubMed id 23437218)1 Teng G.G....Li J. (PLoS ONE 2013)
  2. Suppression of the let-7b microRNA pathway by DNA hypermethylation in infant acute lymphoblastic leukemia with MLL gene rearrangements. (PubMed id 22918121)1 Nishi M....Eguchi M. (Leukemia 2013)
  3. Distinct microRNA expression profile in prostate cancer patients with early clinical failure and the impact of let-7 as prognostic marker in high-risk prostate cancer. (PubMed id 23798998)1 Schubert M....Kneitz B. (PLoS ONE 2013)
  4. Let-7b inhibits human cancer phenotype by targeting cytochrome P450 epoxygenase 2J2. (PubMed id 22761738)1 Chen F....Wang D.W. (PLoS ONE 2012)
  5. An unconventional role for miRNA: let-7 activates Toll-like receptor 7 and causes neurodegeneration. (PubMed id 22610069)1 Lehmann S.M....Lehnardt S. (Nat. Neurosci. 2012)
  6. Circulating miR-30a, miR-195 and let-7b associated with acute myocardial infarction. (PubMed id 23236408)1 Long G....Wang D.W. (PLoS ONE 2012)
  7. Circulating microRNA profiles reflect the presence of breast tumours but not the profiles of microRNAs within the tumours. (PubMed id 22821209)1 Cookson V.J....Hughes T.A. (Cell Oncol (Dordr) 2012)
  8. let-7b and miR-126 are down-regulated in tumor tissue and correlate with microvessel density and survival outcomes in non--small--cell lung cancer. (PubMed id 23029111)1 JusufoviA8 E....KoA!nik M. (PLoS ONE 2012)
  9. Respiratory syncytial virus regulates human microRNAs by using mechanisms involving beta interferon and NF-I_B. (PubMed id 23249809)1 Thornburg N.J....Crowe J.E. (MBio 2012)
  10. Let-7b is a novel regulator of hepatitis C virus replication. (PubMed id 22391672)1 Cheng J.C....Huang H.D. (Cell. Mol. Life Sci. 2012)

(in PubMed, OMIM, and NCBI Bookshelf)
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 ANDOR
Aliases
Free Text  

  Query String
PubMed
OMIM
NCBI Bookshelf
  (Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 406884 HGNC: 31479 Ensembl:ENSG00000207875 miRBase: hsa-let-7b euGenes: HUgn406884
ECgene: MIRLET7B Kegg: 406884 H-InvDB: MIRLET7B

(According to HUGE)
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(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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NameDescription
PharmGKB entry for MIRLET7B Pharmacogenomics, SNPs, Pathways

(Patent information from GeneIP,
Licensable technologies from WIS Yeda, Salk, Tufts,
IP news from LifeMap Sciences, Inc.)
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Patent Information for MIRLET7B gene:
Search GeneIP for patents involving MIRLET7B

GeneCards and IP:
Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
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