MIRLET7B Gene
RNA gene GIFtS: 22
GCID: GC22P046509
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microRNA let-7b
(Previous symbol: MIRNLET7B)
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Aliases
for MIRLET7B gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
Subcategory (RNA class): miRNA
Quality score for this RNA gene is 13
| Aliases |
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| MicroRNA Let-7b1 2 | | MIRNLET7B1 2 5 | | Hsa-Let-7b1 | | Let-7b1 | | LET7B2 5 |
| External Ids: | HGNC: 314791 | Entrez Gene: 4068842 | Ensembl: ENSG000002078757 | OMIM: 6112495 |
Export aliases for MIRLET7B gene to outside databasesPrevious GC identifer: GC22P044889
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Summaries
for MIRLET7B gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for MIRLET7B:
microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of geneexpression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribedby RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be eitherprotein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce anapproximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicerribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporatedinto a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with themiRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeqrepresents the predicted microRNA stem-loop. (provided by RefSeq, Sep 2009)
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Genomic Views
for MIRLET7B gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| Regulatory elements:
 Search SABiosciences Regulatory transcription factor binding sites for MIRLET7B
Other transcription factors
Search SABiosciences Chromatin IP Primers for MIRLET7B
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat MIRLET7B |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 22q13.31 Ensembl cytogenetic band: 22q13.31 HGNC cytogenetic band: 22q13.31MIRLET7B Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 22 GeneLoc Exon Structure GeneLoc location for GC22P046509: view genomic region (via miRBase)
(about GC identifiers)
Start:
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46,509,566 bp from pter |
End:
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46,509,648 bp from pter |
Size:
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83 bases |
Orientation:
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plus strand |
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Proteins
for MIRLET7B gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
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UniProtKB: --
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Protein
Domains /
Families
for MIRLET7B gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
| -- |
Function
for MIRLET7B gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
miRNA
Products: | | miRTarBase genes targeted by MIRLET7B:
NCAPG2(MIRT005219), ERC1(MIRT005238), PGRMC1(MIRT001609), FARP1(MIRT005052), RRP1B(MIRT005231), ATAD3B(MIRT001652), GGCT(MIRT005232), GYS1(MIRT001626), SLC25A32(MIRT001591), TRMT1(MIRT001584), GDE1(MIRT005236), YAP1(MIRT005047), NRAS(MIRT003836), TRABD(MIRT005240), CHPF2(MIRT005223), VPS39(MIRT001579), CDCA7(MIRT005056), RHOB(MIRT001599), TYMS(MIRT001582), DLC1(MIRT005042), PLAGL2(MIRT005038), IFNB1(MIRT004614), DZIP1(MIRT005040), PXDN(MIRT001602), CCNF(MIRT005061), RDH10(MIRT001600), DUSP12(MIRT001636), RPP38(MIRT001597), TAF9B(MIRT001587), FAM203A(MIRT005436), C7orf58(MIRT005053), GRPEL2(MIRT001628), LIN28A(MIRT004011), FAM96A(MIRT001632), HMGA2(MIRT002082), SLC25A13(MIRT001594), IFIT5(MIRT001624), C1orf27(MIRT005235), CCND1(MIRT002484), AKAP8(MIRT001654), MRPS24(MIRT001615), COMMD9(MIRT001641), SCAMP3(MIRT004952), MTRR(MIRT001613), ALG3(MIRT005225), DICER1(MIRT005322), AARSD1(MIRT001655), CDK6(MIRT002297), LIN28B(MIRT003834), RCAN1(MIRT005055), GPX7(MIRT005045), MAP7D1(MIRT005227), ANAPC1(MIRT001653), CDC34(MIRT001229), FNDC3A(MIRT001631), FADS2(MIRT001634), C20orf72(MIRT005230), DCTPP1(MIRT005221), NUDT19(MIRT005229), IGF2BP1(MIRT001621), PRRC2A(MIRT005234), C2orf18(MIRT005243), PDE12(MIRT005039), BIRC6(MIRT004956), CAPG(MIRT001646), HNRPDL(MIRT004954), CCNA2(MIRT003999), GTPBP3(MIRT001627), CDIPT(MIRT001644), POM121(MIRT001606), RPIA(MIRT001851), SLC1A4(MIRT001595), ATP6V0A1(MIRT001651), PPP1R7(MIRT001605), TAB2(MIRT005057), MARS2(MIRT001618), EDEM3(MIRT005222), TTC9C(MIRT001583), SPCS3(MIRT001589), DUSP23(MIRT001635), CIAO1(MIRT005218), CALCOCO2(MIRT001647), CCND2(MIRT003835), DMD(MIRT005060), GZF1(MIRT005048), DOCK5(MIRT001638), GEMIN7(MIRT001630), NR2E1(MIRT004618), IGF2BP2(MIRT005241), MRM1(MIRT001616), SLC25A24(MIRT001592), POLD2(MIRT001608), ARL15(MIRT005226), RBM19(MIRT001601), HMGA1(MIRT001625), SPRYD4(MIRT001588), BCL7A(MIRT002399), PTGS2(MIRT001603), UHRF1(MIRT001580), EIF2C3(MIRT005037), AURKA(MIRT005051), MRPS33(MIRT001614), NAA40(MIRT005239), SNAP23(MIRT001590), SSR1(MIRT005046), THBS1(MIRT001586), SIGMAR1(MIRT005041), CCNJ(MIRT005036), CBFB(MIRT005054), DHX57(MIRT001639), IFRD1(MIRT001623), CCDC115(MIRT005224), E2F6(MIRT005044), ARID3A(MIRT005059), POLR2C(MIRT001607), GPR56(MIRT001629), CSNK1D(MIRT001640), CCBL2(MIRT005220), CDC25A(MIRT002296), MLLT1(MIRT001617), NXT2(MIRT005043), NXN(MIRT001611), CHMP2A(MIRT001642), UGT8(MIRT001581), RHOG(MIRT001598), AURKB(MIRT001649), PDGFRA(MIRT004955), SOX9(MIRT005049), NEDD4(MIRT001612), RRP8(MIRT005242), E2F5(MIRT003833), FAM105A(MIRT001633), GTF2I(MIRT005058), DSP(MIRT001637), SCYL1(MIRT001596), ATP6V1F(MIRT001650), CDKAL1(MIRT001643), ACTG1(MIRT001852), MMS22L(MIRT005233), NAA25(MIRT005228), PRDM1(MIRT005513), IPO4(MIRT001620), PRIM1(MIRT001604), TMEM2(MIRT001585), RRM2(MIRT005050), CARHSP1(MIRT001645) |
| |  | Browse 3'-UTR reporter clones for miRNA target validation
Browse MicroRNA Expression Plasmids
| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat MIRLET7B | | | Search QIAGEN for miScript miRNA Assays for microRNAs that regulate MIRLET7B | |  | SwitchGear 3'UTR luciferase reporter plasmid: MIRLET7B 3' UTR sequence |
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Pathways & Interactions
for MIRLET7B gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
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Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for MIRLET7B
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Drugs & Compounds
for MIRLET7B gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for MIRLET7B
Search CenterWatch for drugs/clinical trials and news about MIRLET7B 
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Transcripts
for MIRLET7B gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
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1 Ensembl transcript including schematic representation, and UCSC links where relevant: ENST00000385140(miRNA)
GeneLoc Exon Structure
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Expression
for MIRLET7B gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| Expression evidence for MIRLET7B:none
MIRLET7B expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: --
About this image SABiosciences Custom PCR Arrays for MIRLET7B
Primer
Products: | | Browse OriGene genome-wide validated SYBR primer pairs
Browse OriGene validated miRNA SYBR primer pairs
| | | Search SABiosciences RT2 qPCR
Primer Assays in human, mouse, rat MIRLET7B | | | Search QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat MIRLET7B | | | Search QIAGEN QuantiFast Probe-based Assays in human, mouse, rat MIRLET7B |
Orthologs
for MIRLET7B gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
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ENSEMBL Gene Tree for MIRLET7B (if available)
TreeFam Gene Tree for MIRLET7B (if available) |
Paralogs
for MIRLET7B gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for MIRLET7B gene
- MIRLET7C2 MIRLET7I2 MIRLET7A22 MIRLET7F22 MIRLET7D2 MIR982 MIRLET7F12 MIRLET7G2
- MIRLET7A12 MIRLET7A32 MIRLET7E2
MIRLET7B for paralogs About GeneDecksing
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Genomic Variants
for MIRLET7B gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 4 variations for MIRLET7B
4 CNVs: 30165 50880 30164 50881 | SABiosciences Cancer Mutation PCR Assays |
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Disorders
/ Diseases
for MIRLET7B gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
MIRLET7B for disorders About GeneDecksing
OMIM gene information: 611249
OMIM disorders: --
2  diseases for MIRLET7B: About MalaCardscervical cancer cervicitis
Human Genome Epidemiology (HuGE) Navigator: MIRLET7B (1 document)
Export disorders for MIRLET7B gene to outside databases
|
Publications
for MIRLET7B gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for MIRLET7B gene, integrated from 9 sources (see all 14):
(articles sorted by number of sources associating them with MIRLET7B) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Circulating microRNA profiles reflect the presence of breast tumours but not the profiles of microRNAs within the tumours. (PubMed id 22821209)1 Cookson V.J....Hughes T.A. (2012)
- Let-7b is a novel regulator of hepatitis C virus repli cation. (PubMed id 22391672)1 Cheng J.C....Huang H.D. (2012)
- Biological and prognostic associations of miR-205 and let-7b in breast cancer revealed by in situ hybridization analysis of micro-RNA expression in arrays of archival tumour tissue. (PubMed id 22294324)1 Quesne J.L....Caldas C. (2012)
- MicroRNAs and cataracts: correlation among let-7 expre ssion, age and the severity of lens opacity. (PubMed id 22334139)1 Peng C.H....Chen S.J. (2012)
- An unconventional role for miRNA: let-7 activates Toll -like receptor 7 and causes neurodegeneration. (PubMed id 22610069)1 Lehmann S.M....Lehnardt S. (2012)
- Cellular stress induced alterations in microRNA let-7 a and let-7b expression are dependent on p53. (PubMed id 22022355)1 Saleh A.D....Simone N.L. (2011)
- MicroRNA regulation of IFN-beta protein expression: r apid and sensitive modulation of the innate immune response. (PubMed id 20130213)1 Witwer K.W....Clements J.E. (2010)
- Patterns of known and novel small RNAs in human cervical cancer. (PubMed id 17616659)1 Lui W.O....Fire A. (2007)
- A mammalian microRNA expression atlas based on small RNA library sequencing. (PubMed id 17604727)1 Landgraf P....Tuschl T. (2007)
- The tumor suppressor microRNA let-7 represses the HMGA2 oncogene. (PubMed id 17437991)1 Lee Y.S. and Dutta A. (2007)
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External Searches for MIRLET7B gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
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Genome Databases showing MIRLET7B gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
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Other Databases showing MIRLET7B gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing MIRLET7B gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for MIRLET7B | Pharmacogenomics, SNPs, Pathways |
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About This Section
| Patent Information for MIRLET7B gene:
Search GeneIP for patents involving MIRLET7B
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for MIRLET7B gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
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|  | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat MIRLET7B | | | Search QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing MIRLET7B | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat MIRLET7B | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat MIRLET7B | | | Search QIAGEN QuantiFast Probe-based Assays in human, mouse, rat MIRLET7B | | | Search QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat MIRLET7B |
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 | | | | |  |  |  | | | | Search ThermoFisher Antibodies for MIRLET7B |
| | | Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat MIRLET7B |
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GeneCards Homepage -
Last full update: 19 Mar 2013 -
Incrementals: 21 Mar 2013 , 15 Apr 2013 , 26 Apr 2013
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