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Aliases for MIRLET7A3 Gene

Subcategory (RNA class) for MIRLET7A3 Gene

miRNA

Quality Score for this RNA gene is

3

Aliases for MIRLET7A3 Gene

  • MicroRNA Let-7a-3 2 3 5
  • Hsa-Let-7a-3 3
  • MIRNLET7A3 3
  • Let-7a-3 3
  • LET7A3 3

External Ids for MIRLET7A3 Gene

ORGUL Members for MIRLET7A3 Gene

Previous HGNC Symbols for MIRLET7A3 Gene

  • MIRNLET7A3

Previous GeneCards Identifiers for MIRLET7A3 Gene

  • GC22P044887
  • GC22P046508
  • GC22P046058

Summaries for MIRLET7A3 Gene

Entrez Gene Summary for MIRLET7A3 Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIRLET7A3 Gene

MIRLET7A3 (MicroRNA Let-7a-3) is an RNA Gene, and is affiliated with the miRNA class. Among its related pathways are MicroRNAs in cancer and Metastatic brain tumor.

Additional gene information for MIRLET7A3 Gene

No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MIRLET7A3 Gene

Genomics for MIRLET7A3 Gene

Genomic Location for MIRLET7A3 Gene

Chromosome:
22
Start:
46,112,749 bp from pter
End:
46,112,822 bp from pter
Size:
74 bases
Orientation:
Plus strand

Genomic View for MIRLET7A3 Gene

Genes around MIRLET7A3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MIRLET7A3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIRLET7A3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIRLET7A3 Gene

No data available for Regulatory Elements for MIRLET7A3 Gene

Proteins for MIRLET7A3 Gene

Post-translational modifications for MIRLET7A3 Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIRLET7A3 Gene

Domains & Families for MIRLET7A3 Gene

Gene Families for MIRLET7A3 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with MIRLET7A3: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for MIRLET7A3 Gene

Function for MIRLET7A3 Gene

Animal Model Products

CRISPR Products

miRNA Products

Clone Products

  • Applied Biological Materials Clones for MIRLET7A3
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIRLET7A3 Gene

Localization for MIRLET7A3 Gene

Gene Ontology (GO) - Cellular Components for MIRLET7A3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005615 extracellular space IDA 18766170
genes like me logo Genes that share ontologies with MIRLET7A3: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS and Subcellular locations from the Human Protein Atlas (HPA) for MIRLET7A3 Gene

Pathways & Interactions for MIRLET7A3 Gene

genes like me logo Genes that share pathways with MIRLET7A3: view

Pathways by source for MIRLET7A3 Gene

1 BioSystems pathway for MIRLET7A3 Gene
1 KEGG pathway for MIRLET7A3 Gene

Interacting Proteins for MIRLET7A3 Gene

Gene Ontology (GO) - Biological Process for MIRLET7A3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0035278 miRNA mediated inhibition of translation IDA 17671087
GO:0098806 deadenylation involved in gene silencing by miRNA IMP 17671087
genes like me logo Genes that share ontologies with MIRLET7A3: view

No data available for SIGNOR curated interactions for MIRLET7A3 Gene

Drugs & Compounds for MIRLET7A3 Gene

No Compound Related Data Available

Transcripts for MIRLET7A3 Gene

mRNA/cDNA for MIRLET7A3 Gene

(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

CRISPR Products

miRNA Products

Clone Products

  • Applied Biological Materials Clones for MIRLET7A3
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

Alternative Splicing Database (ASD) splice patterns (SP) for MIRLET7A3 Gene

No ASD Table

Relevant External Links for MIRLET7A3 Gene

GeneLoc Exon Structure for
MIRLET7A3
ECgene alternative splicing isoforms for
MIRLET7A3

Expression for MIRLET7A3 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for MIRLET7A3 Gene

NURSA nuclear receptor signaling pathways regulating expression of MIRLET7A3 Gene:

MIRLET7A3
genes like me logo Genes that share expression patterns with MIRLET7A3: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for MIRLET7A3 Gene

Orthologs for MIRLET7A3 Gene

Evolution for MIRLET7A3 Gene

ENSEMBL:
Gene Tree for MIRLET7A3 (if available)
TreeFam:
Gene Tree for MIRLET7A3 (if available)

No data available for Orthologs for MIRLET7A3 Gene

Paralogs for MIRLET7A3 Gene

No data available for Paralogs for MIRLET7A3 Gene

Variants for MIRLET7A3 Gene

Sequence variations from dbSNP and Humsavar for MIRLET7A3 Gene

SNP ID Clin Chr 22 pos Sequence Context AA Info Type
rs1000473900 -- 46,111,466(+) AACCC(C/T)CTGTC nc-transcript-variant, upstream-variant-2KB
rs1001370205 -- 46,112,517(+) TTTCC(A/T)GCAGG nc-transcript-variant, upstream-variant-2KB
rs1001637152 -- 46,112,860(+) GTCTG(A/G)AACCC nc-transcript-variant, downstream-variant-500B, upstream-variant-2KB
rs1001883421 -- 46,112,293(+) GGAGG(A/G)GGCCG nc-transcript-variant, upstream-variant-2KB
rs1001900208 -- 46,112,270(+) TTCTG(A/G)TGGCG nc-transcript-variant, upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for MIRLET7A3 Gene

Variant ID Type Subtype PubMed ID
dgv2469n106 OTHER inversion 24896259
nsv1152661 OTHER inversion 26484159
nsv459905 CNV loss 19166990
nsv471212 CNV loss 18288195
nsv471213 CNV gain 18288195
nsv516279 CNV loss 19592680
nsv829281 CNV gain 20364138
nsv829285 CNV gain 20364138
nsv834224 CNV loss 17160897

Relevant External Links for MIRLET7A3 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MIRLET7A3

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Variation tolerance for MIRLET7A3 Gene

Disorders for MIRLET7A3 Gene

Relevant External Links for MIRLET7A3

Genetic Association Database (GAD)
MIRLET7A3
Human Genome Epidemiology (HuGE) Navigator
MIRLET7A3
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
MIRLET7A3

No disorders were found for MIRLET7A3 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MIRLET7A3 Gene

Publications for MIRLET7A3 Gene

  1. Let-7a-3 hypomethylation is associated with favorable/intermediate karyotypes but not with survival in acute myeloid leukemia. (PMID: 26227220) Zhu XW … Qian J (Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine 2016) 3 60
  2. Association of MicroRNAs and YRNAs With Platelet Function. (PMID: 26646931) Kaudewitz D … Mayr M (Circulation research 2016) 3 60
  3. Hepatitis B virus mRNAs functionally sequester let-7a and enhance hepatocellular carcinoma. (PMID: 27693636) Deng M … Meng S (Cancer letters 2016) 3 60
  4. Overexpression of Lin28 inhibits the proliferation, migration and cell cycle progression and induces apoptosis of BGC-823 gastric cancer cells. (PMID: 25515921) Song H … Zheng JN (Oncology reports 2015) 3 60
  5. Tumor-suppressive microRNA-let-7a inhibits cell proliferation via targeting of E2F2 in osteosarcoma cells. (PMID: 25647078) Iwasaki T … Tsumura H (International journal of oncology 2015) 3 60

Products for MIRLET7A3 Gene

Sources for MIRLET7A3 Gene

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