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Aliases for MIRLET7A3 Gene

Subcategory (RNA class) for MIRLET7A3 Gene

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Quality Score for this RNA gene is

3

Aliases for MIRLET7A3 Gene

  • MicroRNA Let-7a-3 2 3
  • MIRNLET7A3 3 6
  • LET7A3 3 6
  • Hsa-Let-7a-3 3
  • Let-7a-3 3

External Ids for MIRLET7A3 Gene

ORGUL Members for MIRLET7A3 Gene

Previous HGNC Symbols for MIRLET7A3 Gene

  • MIRNLET7A3

Previous GeneCards Identifiers for MIRLET7A3 Gene

  • GC22P044887
  • GC22P046508

Summaries for MIRLET7A3 Gene

Entrez Gene Summary for MIRLET7A3 Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIRLET7A3 Gene

MIRLET7A3 (MicroRNA Let-7a-3) is an RNA Gene, and is affiliated with the undefined RNA class. Among its related pathways are MicroRNAs in cancer.

No data available for UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MIRLET7A3 Gene

Genomics for MIRLET7A3 Gene

Genomic Location for MIRLET7A3 Gene

Start:
46,112,732 bp from pter
End:
46,112,840 bp from pter
Size:
109 bases
Orientation:
Plus strand

Genomic View for MIRLET7A3 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for MIRLET7A3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIRLET7A3 Gene

No data available for Regulatory Elements for MIRLET7A3 Gene

Proteins for MIRLET7A3 Gene

Post-translational modifications for MIRLET7A3 Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIRLET7A3 Gene

Domains for MIRLET7A3 Gene

Gene Families for MIRLET7A3 Gene

HGNC:
  • MIR :ncRNAs / Micro RNAs

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with MIRLET7A3: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for MIRLET7A3 Gene

Function for MIRLET7A3 Gene

Animal Model Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for MIRLET7A3 Gene

Localization for MIRLET7A3 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for MIRLET7A3 Gene COMPARTMENTS Subcellular localization image for MIRLET7A3 gene
Compartment Confidence
extracellular 2
cytosol 1
mitochondrion 1
nucleus 1
peroxisome 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for MIRLET7A3 Gene

Pathways for MIRLET7A3 Gene

SuperPathways for MIRLET7A3 Gene

Superpath Contained pathways
1 MicroRNAs in cancer
genes like me logo Genes that share pathways with MIRLET7A3: view

Pathways by source for MIRLET7A3 Gene

1 KEGG pathway for MIRLET7A3 Gene

Interacting Proteins for MIRLET7A3 Gene

Gene Ontology (GO) - Biological Process for MIRLET7A3 Gene

None

Transcripts for MIRLET7A3 Gene

mRNA/cDNA for MIRLET7A3 Gene

(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

miRNA Products

  • QIAGEN qRT-PCR Assays for microRNAs that regulate MIRLET7A3
    • Block miRNA regulation of MIRLET7A3 using miScript Target Protectors

    Inhibitory RNA Products

    • Predesigned siRNA for gene silencing in human,mouse,rat for MIRLET7A3

    Primer Products

    Flow Cytometry Products

    Alternative Splicing Database (ASD) splice patterns (SP) for MIRLET7A3 Gene

    No ASD Table

    Relevant External Links for MIRLET7A3 Gene

    GeneLoc Exon Structure for
    MIRLET7A3
    ECgene alternative splicing isoforms for
    MIRLET7A3

    Expression for MIRLET7A3 Gene

    mRNA expression in normal human tissues for MIRLET7A3 Gene

    genes like me logo Genes that share expressions with MIRLET7A3: view

    In Situ Assay Products

    No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein expression and mRNA Expression by UniProt/SwissProt for MIRLET7A3 Gene

    Orthologs for MIRLET7A3 Gene

    This gene was present in the common ancestor of chordates.

    Orthologs for MIRLET7A3 Gene

    Organism Taxonomy Gene Similarity Type Details
    chimpanzee
    (Pan troglodytes)
    Mammalia ptr-let-7a-3 36
    • 100 (a)
    OneToOne
    cow
    (Bos Taurus)
    Mammalia bta-let-7a-3 36
    • 100 (a)
    OneToOne
    dog
    (Canis familiaris)
    Mammalia cfa-let-7a-1 36
    • 94 (a)
    OneToOne
    mouse
    (Mus musculus)
    Mammalia Mirlet7c-2 36
    • 66 (a)
    OneToOne
    oppossum
    (Monodelphis domestica)
    Mammalia mdo-let-7a-3 36
    • 76 (a)
    OneToOne
    platypus
    (Ornithorhynchus anatinus)
    Mammalia -- 36
    • 63 (a)
    OneToOne
    chicken
    (Gallus gallus)
    Aves gga-let-7j 36
    • 70 (a)
    ManyToMany
    lizard
    (Anolis carolinensis)
    Reptilia aca-let-7c-2 36
    • 48 (a)
    ManyToMany
    zebrafish
    (Danio rerio)
    Actinopterygii dre-let-7g-1 36
    • 56 (a)
    OneToOne
    sea squirt
    (Ciona savignyi)
    Ascidiacea csa-let-7b 36
    • 41 (a)
    OneToMany
    csa-let-7c-2 36
    • 44 (a)
    OneToMany
    Species with no ortholog for MIRLET7A3:
    • A. gosspyii yeast (Ashbya gossypii)
    • Actinobacteria (Mycobacterium tuberculosis)
    • African clawed frog (Xenopus laevis)
    • African malaria mosquito (Anopheles gambiae)
    • Alicante grape (Vitis vinifera)
    • alpha proteobacteria (Wolbachia pipientis)
    • amoeba (Dictyostelium discoideum)
    • Archea (Pyrococcus horikoshii)
    • baker's yeast (Saccharomyces cerevisiae)
    • barley (Hordeum vulgare)
    • beta proteobacteria (Neisseria meningitidis)
    • bread mold (Neurospora crassa)
    • Chromalveolata (Phytophthora infestans)
    • common water flea (Daphnia pulex)
    • corn (Zea mays)
    • E. coli (Escherichia coli)
    • filamentous fungi (Aspergillus nidulans)
    • Firmicute bacteria (Streptococcus pneumoniae)
    • fission yeast (Schizosaccharomyces pombe)
    • fruit fly (Drosophila melanogaster)
    • green algae (Chlamydomonas reinhardtii)
    • honey bee (Apis mellifera)
    • K. lactis yeast (Kluyveromyces lactis)
    • loblloly pine (Pinus taeda)
    • malaria parasite (Plasmodium falciparum)
    • medicago trunc (Medicago Truncatula)
    • moss (Physcomitrella patens)
    • orangutan (Pongo pygmaeus)
    • pig (Sus scrofa)
    • rainbow trout (Oncorhynchus mykiss)
    • rat (Rattus norvegicus)
    • rice (Oryza sativa)
    • rice blast fungus (Magnaporthe grisea)
    • schistosome parasite (Schistosoma mansoni)
    • sea anemone (Nematostella vectensis)
    • sea urchin (Strongylocentrotus purpuratus)
    • sorghum (Sorghum bicolor)
    • soybean (Glycine max)
    • stem rust fungus (Puccinia graminis)
    • sugarcane (Saccharum officinarum)
    • thale cress (Arabidopsis thaliana)
    • tomato (Lycopersicon esculentum)
    • toxoplasmosis (Toxoplasma gondii)
    • Trichoplax (Trichoplax adhaerens)
    • tropical clawed frog (Silurana tropicalis)
    • wheat (Triticum aestivum)
    • worm (Caenorhabditis elegans)

    Evolution for MIRLET7A3 Gene

    ENSEMBL:
    Gene Tree for MIRLET7A3 (if available)
    TreeFam:
    Gene Tree for MIRLET7A3 (if available)

    Paralogs for MIRLET7A3 Gene

    No data available for Paralogs for MIRLET7A3 Gene

    Variants for MIRLET7A3 Gene

    Structural Variations from Database of Genomic Variants (DGV) for MIRLET7A3 Gene

    Variant ID Type Subtype PubMed ID
    dgv5004n71 CNV Loss 21882294
    nsv829281 CNV Gain 20364138
    dgv5006n71 CNV Loss 21882294
    dgv5008n71 CNV Loss 21882294
    nsv829285 CNV Gain 20364138
    nsv471212 CNV Loss 18288195
    dgv5009n71 CNV Loss 21882294
    dgv5010n71 CNV Loss 21882294
    nsv915336 CNV Loss 21882294
    nsv471213 CNV Gain 18288195
    nsv915337 CNV Loss 21882294
    dgv5011n71 CNV Loss 21882294
    nsv516279 CNV Loss 19592680
    nsv915340 CNV Loss 21882294
    dgv5012n71 CNV Loss 21882294
    nsv915344 CNV Loss 21882294
    nsv459905 CNV Loss 19166990
    nsv834224 CNV Loss 17160897

    Relevant External Links for MIRLET7A3 Gene

    HapMap Linkage Disequilibrium report
    MIRLET7A3

    No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Sequence variations from dbSNP and Humsavar for MIRLET7A3 Gene

    Disorders for MIRLET7A3 Gene

    Relevant External Links for MIRLET7A3

    Genetic Association Database (GAD)
    MIRLET7A3
    Human Genome Epidemiology (HuGE) Navigator
    MIRLET7A3
    genes like me logo Genes that share disorders with MIRLET7A3: view

    No data available for UniProtKB/Swiss-Prot for MIRLET7A3 Gene

    Publications for MIRLET7A3 Gene

    1. Identification of novel genes coding for small expressed RNAs. (PMID: 11679670) Lagos-Quintana M. … Tuschl T. (Science 2001) 3
    2. Numerous microRNPs in neuronal cells containing novel microRNAs. (PMID: 12554860) Dostie J. … Dreyfuss G. (RNA 2003) 3
    3. Reduced accumulation of specific microRNAs in colorectal neoplasia. (PMID: 14573789) Michael M.Z. … James R.J. (Mol. Cancer Res. 2003) 3
    4. Human embryonic stem cells express a unique set of microRNAs. (PMID: 15183728) Suh M.R. … Kim K.S. (Dev. Biol. 2004) 3
    5. Altered expression profiles of microRNAs during TPA-induced differentiation of HL-60 cells. (PMID: 15325244) Kasashima K. … Kozu T. (Biochem. Biophys. Res. Commun. 2004) 3

    Products for MIRLET7A3 Gene

    Sources for MIRLET7A3 Gene

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