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Aliases for MIRLET7A3 Gene

Subcategory (RNA class) for MIRLET7A3 Gene

miRNA

Quality Score for this RNA gene is

3

Aliases for MIRLET7A3 Gene

  • MicroRNA Let-7a-3 2 3
  • MIRLET7B Host Gene 5
  • Hsa-Let-7a-3 3
  • MIRLET7BHG 5
  • MIRNLET7A3 3
  • Let-7a-3 3
  • LET7A3 3

External Ids for MIRLET7A3 Gene

Previous HGNC Symbols for MIRLET7A3 Gene

  • MIRNLET7A3

Previous GeneCards Identifiers for MIRLET7A3 Gene

  • GC22P044887
  • GC22P046508
  • GC22P046112

Summaries for MIRLET7A3 Gene

Entrez Gene Summary for MIRLET7A3 Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIRLET7A3 Gene

MIRLET7A3 (MicroRNA Let-7a-3) is an RNA Gene, and is affiliated with the miRNA class. Among its related pathways are MicroRNAs in cancer.

No data available for UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MIRLET7A3 Gene

Genomics for MIRLET7A3 Gene

Regulatory Elements for MIRLET7A3 Gene

Enhancers for MIRLET7A3 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH22F046005 1.4 FANTOM5 Ensembl ENCODE 12.9 -43.2 -43229 9.7 HDGF PKNOX1 ARID4B SIN3A DMAP1 ZNF2 YY1 ZNF143 ZNF548 FOS LINC00899 RPS10P31 ENSG00000273243 LOC642648 MIRLET7A3 MIR4763 MIRLET7B MIRLET7BHG PRR34 PRR34-AS1
GH22F046000 0.8 Ensembl ENCODE 12.8 -51.1 -51069 4.4 BCOR TBP CTCF KLF17 ZMYM3 ZIC2 RAD21 ZFHX2 GLIS2 ZBTB48 LINC00899 MIRLET7A3 LOC642648 MIR4763 MIRLET7B MIRLET7BHG PRR34 PRR34-AS1 ENSG00000231010 GC22M045913
GH22F046022 0.2 ENCODE 12.6 -30.0 -30002 1.8 KLF17 ZIC2 HIC1 ZNF664 ZFHX2 ZNF157 ZNF366 FOS EGR2 NRF1 LINC00899 LOC642648 PRR34-AS1 MIR4763 MIRLET7A3 MIRLET7B MIRLET7BHG ENSG00000231010 PRR34 ENSG00000273145
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around MIRLET7A3 on UCSC Golden Path with GeneCards custom track

Promoters for MIRLET7A3 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00001533300 331 2001 PKNOX1 SIN3A FEZF1 GLI4 YBX1 ZNF2 ZNF121 GLIS2 KLF7 FOS
ENSR00001844271 1831 201 ZFHX2 KLF4 ZNF600 PRDM1 TRIM28 EGR2

Genomic Location for MIRLET7A3 Gene

Chromosome:
22
Start:
46,053,869 bp from pter
End:
46,113,928 bp from pter
Size:
60,060 bases
Orientation:
Plus strand

Genomic View for MIRLET7A3 Gene

Genes around MIRLET7A3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MIRLET7A3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIRLET7A3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIRLET7A3 Gene

Proteins for MIRLET7A3 Gene

Post-translational modifications for MIRLET7A3 Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIRLET7A3 Gene

Domains & Families for MIRLET7A3 Gene

Gene Families for MIRLET7A3 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with MIRLET7A3: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for MIRLET7A3 Gene

Function for MIRLET7A3 Gene

Animal Model Products

miRNA Products

Clone Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIRLET7A3 Gene

Localization for MIRLET7A3 Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS and Gene Ontology (GO) - Cellular Components for MIRLET7A3 Gene

Pathways & Interactions for MIRLET7A3 Gene

SuperPathways for MIRLET7A3 Gene

SuperPathway Contained pathways
1 MicroRNAs in cancer
genes like me logo Genes that share pathways with MIRLET7A3: view

Pathways by source for MIRLET7A3 Gene

1 KEGG pathway for MIRLET7A3 Gene

Interacting Proteins for MIRLET7A3 Gene

Gene Ontology (GO) - Biological Process for MIRLET7A3 Gene

None

No data available for SIGNOR curated interactions for MIRLET7A3 Gene

Transcripts for MIRLET7A3 Gene

mRNA/cDNA for MIRLET7A3 Gene

(7) Ensembl transcripts including schematic representations, and UCSC links where relevant :

miRNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for MIRLET7A3 Gene

No ASD Table

Relevant External Links for MIRLET7A3 Gene

GeneLoc Exon Structure for
MIRLET7A3
ECgene alternative splicing isoforms for
MIRLET7A3

Expression for MIRLET7A3 Gene

mRNA expression in normal human tissues for MIRLET7A3 Gene

NURSA nuclear receptor signaling pathways regulating expression of MIRLET7A3 Gene:

MIRLET7A3
genes like me logo Genes that share expression patterns with MIRLET7A3: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners and mRNA Expression by UniProt/SwissProt for MIRLET7A3 Gene

Orthologs for MIRLET7A3 Gene

This gene was present in the common ancestor of human and chimp.

Orthologs for MIRLET7A3 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia -- 35
  • 96 (a)
OneToOne
Species where no ortholog for MIRLET7A3 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for MIRLET7A3 Gene

ENSEMBL:
Gene Tree for MIRLET7A3 (if available)
TreeFam:
Gene Tree for MIRLET7A3 (if available)

Paralogs for MIRLET7A3 Gene

No data available for Paralogs for MIRLET7A3 Gene

Variants for MIRLET7A3 Gene

Sequence variations from dbSNP and Humsavar for MIRLET7A3 Gene

SNP ID Clin Chr 22 pos Sequence Context AA Info Type
rs11090909 -- 46,111,049(+) CCCCT(A/C)GGGAG nc-transcript-variant, upstream-variant-2KB
rs11090910 -- 46,111,790(+) TCGTA(C/T)CTGCC nc-transcript-variant, upstream-variant-2KB
rs11090911 -- 46,111,898(+) TCTCT(C/T)GCCAC nc-transcript-variant, upstream-variant-2KB
rs11090912 -- 46,111,975(+) CTGTG(C/T)GTCCC nc-transcript-variant, upstream-variant-2KB
rs111399734 -- 46,112,090(+) ACTTC(C/T)CTCAA nc-transcript-variant, upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for MIRLET7A3 Gene

Variant ID Type Subtype PubMed ID
dgv2469n106 OTHER inversion 24896259
nsv1152661 OTHER inversion 26484159
nsv459905 CNV loss 19166990
nsv471212 CNV loss 18288195
nsv471213 CNV gain 18288195
nsv516279 CNV loss 19592680
nsv829281 CNV gain 20364138
nsv829285 CNV gain 20364138
nsv834224 CNV loss 17160897

Relevant External Links for MIRLET7A3 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MIRLET7A3

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Variation tolerance for MIRLET7A3 Gene

Disorders for MIRLET7A3 Gene

Relevant External Links for MIRLET7A3

Genetic Association Database (GAD)
MIRLET7A3
Human Genome Epidemiology (HuGE) Navigator
MIRLET7A3
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
MIRLET7A3

No disorders were found for MIRLET7A3 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MIRLET7A3 Gene

Publications for MIRLET7A3 Gene

  1. Overexpression of Lin28 inhibits the proliferation, migration and cell cycle progression and induces apoptosis of BGC-823 gastric cancer cells. (PMID: 25515921) Song H. … Zheng J.N. (Oncol. Rep. 2015) 3 64
  2. Tumor-suppressive microRNA-let-7a inhibits cell proliferation via targeting of E2F2 in osteosarcoma cells. (PMID: 25647078) Iwasaki T. … Tsumura H. (Int. J. Oncol. 2015) 3 64
  3. Expression of circulating microRNA-20a and let-7a in esophageal squamous cell carcinoma. (PMID: 25914476) He F.C. … Ming L. (World J. Gastroenterol. 2015) 3 64
  4. Promoter hypermethylation of let-7a-3 is relevant to its down-expression in diabetic nephropathy by targeting UHRF1. (PMID: 26049093) Peng R. … Zhang Z. (Gene 2015) 3 64
  5. USP35 activated by miR let-7a inhibits cell proliferation and NF-I_B activation through stabilization of ABIN-2. (PMID: 26348204) Liu C. … Zhang P. (Oncotarget 2015) 3 64

Products for MIRLET7A3 Gene

Sources for MIRLET7A3 Gene

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