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Aliases for MIRLET7A2 Gene

Subcategory (RNA class) for MIRLET7A2 Gene

miRNA

Quality Score for this RNA gene is

8.2

Aliases for MIRLET7A2 Gene

  • MicroRNA Let-7a-2 2 3
  • MIRNLET7A2 3 6
  • LET7A2 3 6
  • Hsa-Let-7a-2 3
  • Let-7a-2 3

External Ids for MIRLET7A2 Gene

Previous HGNC Symbols for MIRLET7A2 Gene

  • MIRNLET7A2

Previous GeneCards Identifiers for MIRLET7A2 Gene

  • GC11M121525
  • GC11M122017

Summaries for MIRLET7A2 Gene

Entrez Gene Summary for MIRLET7A2 Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIRLET7A2 Gene

MIRLET7A2 (MicroRNA Let-7a-2) is an RNA Gene, and is affiliated with the miRNA class. Among its related pathways are MicroRNAs in cancer.

fRNAdb sequence ontologies for MIRLET7A2 Gene

  • nc_conserved_region: Non-coding region of sequence similarity by descent from a common ancestor.

View fRNAdb secondary structures for MIRLET7A2

No data available for UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary and piRNA Summary for MIRLET7A2 Gene

Genomics for MIRLET7A2 Gene

Genomic Location for MIRLET7A2 Gene

Start:
122,146,521 bp from pter
End:
122,146,593 bp from pter
Size:
73 bases
Orientation:
Minus strand

Genomic View for MIRLET7A2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for MIRLET7A2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIRLET7A2 Gene

ORGUL Member Location for MIRLET7A2 Gene

ORGUL Member Location for MIRLET7A2 gene

No data available for Regulatory Elements for MIRLET7A2 Gene

Proteins for MIRLET7A2 Gene

Post-translational modifications for MIRLET7A2 Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIRLET7A2 Gene

Domains for MIRLET7A2 Gene

Gene Families for MIRLET7A2 Gene

HGNC:
  • MIR :ncRNAs / Micro RNAs

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with MIRLET7A2: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for MIRLET7A2 Gene

Function for MIRLET7A2 Gene

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for MIRLET7A2 Gene

Localization for MIRLET7A2 Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS and Gene Ontology (GO) - Cellular Components for MIRLET7A2 Gene

Pathways for MIRLET7A2 Gene

SuperPathways for MIRLET7A2 Gene

Superpath Contained pathways
1 MicroRNAs in cancer
genes like me logo Genes that share pathways with MIRLET7A2: view

Pathways by source for MIRLET7A2 Gene

1 KEGG pathway for MIRLET7A2 Gene

Interacting Proteins for MIRLET7A2 Gene

Gene Ontology (GO) - Biological Process for MIRLET7A2 Gene

None

Transcripts for MIRLET7A2 Gene

fRNAdb Secondary structures for MIRLET7A2 Gene

  • hsa-let-7a-2_MI0000061_Homo_sapiens_let-7a-2_stem-loop_hairpin

mRNA/cDNA for MIRLET7A2 Gene

(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Alternative Splicing Database (ASD) splice patterns (SP) for MIRLET7A2 Gene

No ASD Table

Relevant External Links for MIRLET7A2 Gene

GeneLoc Exon Structure for
MIRLET7A2
ECgene alternative splicing isoforms for
MIRLET7A2

Expression for MIRLET7A2 Gene

No Expression Related Data Available

No data available for mRNA expression in normal human tissues , mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein expression and mRNA Expression by UniProt/SwissProt for MIRLET7A2 Gene

Orthologs for MIRLET7A2 Gene

This gene was present in the common ancestor of chordates.

Orthologs for MIRLET7A2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ptr-let-7a-2 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia bta-let-7a-2 36
  • 100 (a)
OneToOne
dog
(Canis familiaris)
Mammalia cfa-let-7a-2 36
  • 68 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Mirlet7a-2 36
  • 67 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia mdo-let-7a-2 36
  • 100 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 69 (a)
OneToOne
chicken
(Gallus gallus)
Aves gga-let-7a-2 36
  • 92 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 77 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii dre-let-7a-2 36
  • 80 (a)
OneToOne
sea squirt
(Ciona savignyi)
Ascidiacea csa-let-7c-1 36
  • 42 (a)
OneToMany
Species with no ortholog for MIRLET7A2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for MIRLET7A2 Gene

ENSEMBL:
Gene Tree for MIRLET7A2 (if available)
TreeFam:
Gene Tree for MIRLET7A2 (if available)

Paralogs for MIRLET7A2 Gene

No data available for Paralogs for MIRLET7A2 Gene

Variants for MIRLET7A2 Gene

Structural Variations from Database of Genomic Variants (DGV) for MIRLET7A2 Gene

Variant ID Type Subtype PubMed ID
dgv17n68 CNV Gain 17160897
nsv898430 CNV Gain 21882294
esv275465 CNV Gain+Loss 21479260

Relevant External Links for MIRLET7A2 Gene

HapMap Linkage Disequilibrium report
MIRLET7A2
Human Gene Mutation Database (HGMD)
MIRLET7A2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Sequence variations from dbSNP and Humsavar for MIRLET7A2 Gene

Disorders for MIRLET7A2 Gene

Relevant External Links for MIRLET7A2

Genetic Association Database (GAD)
MIRLET7A2
Human Genome Epidemiology (HuGE) Navigator
MIRLET7A2
genes like me logo Genes that share disorders with MIRLET7A2: view

No data available for UniProtKB/Swiss-Prot for MIRLET7A2 Gene

Publications for MIRLET7A2 Gene

  1. Identification of novel genes coding for small expressed RNAs. (PMID: 11679670) Lagos-Quintana M. … Tuschl T. (Science 2001) 3
  2. Numerous microRNPs in neuronal cells containing novel microRNAs. (PMID: 12554860) Dostie J. … Dreyfuss G. (RNA 2003) 3
  3. Reduced accumulation of specific microRNAs in colorectal neoplasia. (PMID: 14573789) Michael M.Z. … James R.J. (Mol. Cancer Res. 2003) 3
  4. Human embryonic stem cells express a unique set of microRNAs. (PMID: 15183728) Suh M.R. … Kim K.S. (Dev. Biol. 2004) 3
  5. Altered expression profiles of microRNAs during TPA-induced differentiation of HL-60 cells. (PMID: 15325244) Kasashima K. … Kozu T. (Biochem. Biophys. Res. Commun. 2004) 3

Products for MIRLET7A2 Gene

Sources for MIRLET7A2 Gene

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