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Aliases for MIRLET7A2 Gene

Subcategory (RNA class) for MIRLET7A2 Gene


Quality Score for this RNA gene is


Aliases for MIRLET7A2 Gene

  • MicroRNA Let-7a-2 2 3 5
  • Hsa-Let-7a-2 3
  • MIRNLET7A2 3
  • Let-7a-2 3
  • LET7A2 3

External Ids for MIRLET7A2 Gene

Previous HGNC Symbols for MIRLET7A2 Gene


Previous GeneCards Identifiers for MIRLET7A2 Gene

  • GC11M121525
  • GC11M122017

Summaries for MIRLET7A2 Gene

Entrez Gene Summary for MIRLET7A2 Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIRLET7A2 Gene

MIRLET7A2 (MicroRNA Let-7a-2) is an RNA Gene, and is affiliated with the miRNA class. Among its related pathways are MicroRNAs in cancer and Metastatic brain tumor.

fRNAdb sequence ontologies for MIRLET7A2 Gene

  • nc_conserved_region: Non-coding region of sequence similarity by descent from a common ancestor.

View fRNAdb secondary structures for MIRLET7A2

Additional gene information for MIRLET7A2 Gene

No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary and piRNA Summary for MIRLET7A2 Gene

Genomics for MIRLET7A2 Gene

Regulatory Elements for MIRLET7A2 Gene

Enhancers for MIRLET7A2 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH11H122185 1.6 FANTOM5 Ensembl ENCODE dbSUPER 11.3 -45.6 -45632 13.3 GTF2F1 TBP FOXA2 JUN MAX CHD4 RAD21 BATF RFX5 ZKSCAN1 MIRLET7A2 BLID MIR100HG ENSG00000255219 GC11M122182 GC11P122184
GH11H122150 0.9 ENCODE dbSUPER 0.7 -4.9 -4947 2.4 HMG20B FOXA2 ZNF792 TEAD1 FOXA3 HLF HMG20A TEAD3 RERE TCF7 BLID MIR100HG GC11M122153 MIRLET7A2
GH11H122144 0.8 ENCODE dbSUPER 0.7 -0.2 -230 3.9 JUND JUN USF2 EP300 BLID MIR100HG MIRLET7A2 GC11M122153
GH11H122135 1.3 Ensembl ENCODE dbSUPER 0.4 +7.7 7717 7.3 FOXA2 JUN BRCA1 YY1 ETS1 GATA3 POLR2A RERE HNF4G FOS BLID MIR100HG MIRLET7A2 GC11P122118
GH11H122149 0.5 ENCODE dbSUPER 0.7 -2.8 -2835 0.2 BLID MIR100HG GC11M122153 MIRLET7A2
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around MIRLET7A2 on UCSC Golden Path with GeneCards custom track

Genomic Locations for MIRLET7A2 Gene

Genomic Locations for MIRLET7A2 Gene
72 bases
Minus strand

Genomic View for MIRLET7A2 Gene

Genes around MIRLET7A2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MIRLET7A2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIRLET7A2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIRLET7A2 Gene

ORGUL Member Location for MIRLET7A2 Gene

ORGUL Member Location for MIRLET7A2 gene

Proteins for MIRLET7A2 Gene

Post-translational modifications for MIRLET7A2 Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIRLET7A2 Gene

Domains & Families for MIRLET7A2 Gene

Gene Families for MIRLET7A2 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with MIRLET7A2: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for MIRLET7A2 Gene

Function for MIRLET7A2 Gene

Animal Model Products

miRNA Products

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIRLET7A2 Gene

Localization for MIRLET7A2 Gene

Gene Ontology (GO) - Cellular Components for MIRLET7A2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005615 extracellular space IDA 18766170
genes like me logo Genes that share ontologies with MIRLET7A2: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS and Subcellular locations from the Human Protein Atlas (HPA) for MIRLET7A2 Gene

Pathways & Interactions for MIRLET7A2 Gene

genes like me logo Genes that share pathways with MIRLET7A2: view

Pathways by source for MIRLET7A2 Gene

1 BioSystems pathway for MIRLET7A2 Gene
1 KEGG pathway for MIRLET7A2 Gene

Interacting Proteins for MIRLET7A2 Gene

Gene Ontology (GO) - Biological Process for MIRLET7A2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0035278 miRNA mediated inhibition of translation IDA 17671087
GO:0098806 deadenylation involved in gene silencing by miRNA IMP 17671087
genes like me logo Genes that share ontologies with MIRLET7A2: view

No data available for SIGNOR curated interactions for MIRLET7A2 Gene

Drugs & Compounds for MIRLET7A2 Gene

No Compound Related Data Available

Transcripts for MIRLET7A2 Gene

fRNAdb Secondary structures for MIRLET7A2 Gene

  • hsa-let-7a-2_MI0000061_Homo_sapiens_let-7a-2_stem-loop_hairpin

mRNA/cDNA for MIRLET7A2 Gene

(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

miRNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for MIRLET7A2 Gene

No ASD Table

Relevant External Links for MIRLET7A2 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for MIRLET7A2 Gene

NURSA nuclear receptor signaling pathways regulating expression of MIRLET7A2 Gene:

No Expression Related Data Available

No data available for mRNA expression in normal human tissues , mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for MIRLET7A2 Gene

Orthologs for MIRLET7A2 Gene

This gene was present in the common ancestor of chordates.

Orthologs for MIRLET7A2 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia bta-let-7a-2 34
  • 100 (a)
(Monodelphis domestica)
Mammalia mdo-let-7a-2 34
  • 100 (a)
(Pan troglodytes)
Mammalia ptr-let-7a-2 34
  • 100 (a)
(Ornithorhynchus anatinus)
Mammalia -- 34
  • 69 (a)
(Canis familiaris)
Mammalia cfa-let-7a-2 34
  • 68 (a)
(Mus musculus)
Mammalia Mirlet7a-2 34
  • 67 (a)
(Gallus gallus)
Aves gga-let-7a-2 34
  • 92 (a)
(Anolis carolinensis)
Reptilia -- 34
  • 77 (a)
(Danio rerio)
Actinopterygii dre-let-7a-2 34
  • 80 (a)
sea squirt
(Ciona savignyi)
Ascidiacea csa-let-7c-1 34
  • 42 (a)
Species where no ortholog for MIRLET7A2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for MIRLET7A2 Gene

Gene Tree for MIRLET7A2 (if available)
Gene Tree for MIRLET7A2 (if available)

Paralogs for MIRLET7A2 Gene

No data available for Paralogs for MIRLET7A2 Gene

Variants for MIRLET7A2 Gene

Sequence variations from dbSNP and Humsavar for MIRLET7A2 Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type
rs1000060316 -- 122,147,981(+) TTAGA(G/T)CAAGG intron-variant, upstream-variant-2KB
rs1000351087 -- 122,146,233(+) CAGCA(-/T)TTTTT intron-variant, downstream-variant-500B
rs1000670979 -- 122,146,444(+) CGTAC(A/C)CAATC intron-variant, downstream-variant-500B
rs1000989418 -- 122,147,905(+) TTCCA(A/G)CCCTA intron-variant, upstream-variant-2KB
rs1003176772 -- 122,148,445(+) CAGAG(A/C)GGGCA intron-variant, upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for MIRLET7A2 Gene

Variant ID Type Subtype PubMed ID
esv275465 CNV gain+loss 21479260
dgv17n68 CNV gain 17160897

Relevant External Links for MIRLET7A2 Gene

Human Gene Mutation Database (HGMD)
SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Variation tolerance for MIRLET7A2 Gene

Disorders for MIRLET7A2 Gene

Relevant External Links for MIRLET7A2

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for MIRLET7A2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MIRLET7A2 Gene

Publications for MIRLET7A2 Gene

  1. Association of MicroRNAs and YRNAs With Platelet Function. (PMID: 26646931) Kaudewitz D … Mayr M (Circulation research 2016) 3 60
  2. Hepatitis B virus mRNAs functionally sequester let-7a and enhance hepatocellular carcinoma. (PMID: 27693636) Deng M … Meng S (Cancer letters 2016) 3 60
  3. Expression of circulating microRNA-20a and let-7a in esophageal squamous cell carcinoma. (PMID: 25914476) He FC … Ming L (World journal of gastroenterology 2015) 3 60
  4. USP35 activated by miR let-7a inhibits cell proliferation and NF-κB activation through stabilization of ABIN-2. (PMID: 26348204) Liu C … Zhang P (Oncotarget 2015) 3 60
  5. The association between let-7, RAS and HIF-1α in Ewing Sarcoma tumor growth. (PMID: 26393682) Hameiri-Grossman M … Avigad S (Oncotarget 2015) 3 60

Products for MIRLET7A2 Gene

Sources for MIRLET7A2 Gene

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