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Aliases for MIRLET7A1 Gene

Subcategory (RNA class) for MIRLET7A1 Gene

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Quality Score for this RNA gene is

3

Aliases for MIRLET7A1 Gene

  • MicroRNA Let-7a-1 2 3 5
  • Hsa-Let-7a-1 3
  • MIRNLET7A1 3
  • Let-7a-1 3
  • LET7A1 3

External Ids for MIRLET7A1 Gene

ORGUL Members for MIRLET7A1 Gene

Previous HGNC Symbols for MIRLET7A1 Gene

  • MIRNLET7A1

Previous GeneCards Identifiers for MIRLET7A1 Gene

  • GC09P095981
  • GC09P096938

Summaries for MIRLET7A1 Gene

Entrez Gene Summary for MIRLET7A1 Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIRLET7A1 Gene

MIRLET7A1 (MicroRNA Let-7a-1) is an RNA Gene, and is affiliated with the undefined RNA class. Among its related pathways are MicroRNAs in cancer and miRNAs involved in DNA damage response.

Additional gene information for MIRLET7A1 Gene

No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MIRLET7A1 Gene

Genomics for MIRLET7A1 Gene

Regulatory Elements for MIRLET7A1 Gene

Enhancers for MIRLET7A1 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH09H094083 1.1 Ensembl ENCODE 9.7 -91.0 -90994 2 TBP MXI1 GTF2E2 MAX BMI1 ZIC2 ZNF644 ZFHX2 MTA3 CTBP1 MIRLET7D MIRLET7A1 MIRLET7F1 PTPDC1 CYCSP24 LOC105376152
GH09H094212 0.9 ENCODE 11.3 +36.7 36713 0 HDAC1 ATF1 TBL1XR1 CHAMP1 TCF12 ZNF766 GATA2 ELK1 ATF7 CREM MIRLET7D MIRLET7F1 MIRLET7A1 ENSG00000269946 LOC100132077 MIRLET7DHG PIR33030
GH09H094065 0.9 Ensembl ENCODE 11.2 -110.3 -110257 0 CTCF ZNF654 IRF2 MAZ ARNT TRIM22 REST RAD21 MEF2D CC2D1A MIRLET7A1 MIRLET7D MIRLET7F1 CYCSP24 LOC105376152
GH09H094110 0.9 ENCODE 10.7 -64.9 -64907 1 HDAC1 PKNOX1 ATF1 TBL1XR1 ARNT TCF12 GATA2 ATF7 CEBPB NCOA1 MIRLET7A1 MIRLET7D MIRLET7F1 BARX1-AS1 LOC105376152 CYCSP24
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around MIRLET7A1 on UCSC Golden Path with GeneCards custom track

Genomic Location for MIRLET7A1 Gene

Chromosome:
9
Start:
94,175,957 bp from pter
End:
94,176,036 bp from pter
Size:
80 bases
Orientation:
Plus strand

Genomic View for MIRLET7A1 Gene

Genes around MIRLET7A1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MIRLET7A1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIRLET7A1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIRLET7A1 Gene

Proteins for MIRLET7A1 Gene

Post-translational modifications for MIRLET7A1 Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIRLET7A1 Gene

Domains & Families for MIRLET7A1 Gene

Gene Families for MIRLET7A1 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with MIRLET7A1: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for MIRLET7A1 Gene

Function for MIRLET7A1 Gene

Animal Model Products

CRISPR Products

miRNA Products

Clone Products

  • Applied Biological Materials Clones for MIRLET7A1
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIRLET7A1 Gene

Localization for MIRLET7A1 Gene

Gene Ontology (GO) - Cellular Components for MIRLET7A1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005615 extracellular space IDA 18766170
genes like me logo Genes that share ontologies with MIRLET7A1: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS and Subcellular locations from the Human Protein Atlas (HPA) for MIRLET7A1 Gene

Pathways & Interactions for MIRLET7A1 Gene

genes like me logo Genes that share pathways with MIRLET7A1: view

Pathways by source for MIRLET7A1 Gene

2 BioSystems pathways for MIRLET7A1 Gene
1 KEGG pathway for MIRLET7A1 Gene

Interacting Proteins for MIRLET7A1 Gene

Gene Ontology (GO) - Biological Process for MIRLET7A1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0035278 miRNA mediated inhibition of translation IDA 17671087
GO:0098806 deadenylation involved in gene silencing by miRNA IMP 17671087
genes like me logo Genes that share ontologies with MIRLET7A1: view

No data available for SIGNOR curated interactions for MIRLET7A1 Gene

Drugs & Compounds for MIRLET7A1 Gene

No Compound Related Data Available

Transcripts for MIRLET7A1 Gene

mRNA/cDNA for MIRLET7A1 Gene

(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

CRISPR Products

miRNA Products

Clone Products

  • Applied Biological Materials Clones for MIRLET7A1
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

Alternative Splicing Database (ASD) splice patterns (SP) for MIRLET7A1 Gene

No ASD Table

Relevant External Links for MIRLET7A1 Gene

GeneLoc Exon Structure for
MIRLET7A1
ECgene alternative splicing isoforms for
MIRLET7A1

Expression for MIRLET7A1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for MIRLET7A1 Gene

NURSA nuclear receptor signaling pathways regulating expression of MIRLET7A1 Gene:

MIRLET7A1
genes like me logo Genes that share expression patterns with MIRLET7A1: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for MIRLET7A1 Gene

Orthologs for MIRLET7A1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for MIRLET7A1 Gene

Organism Taxonomy Gene Similarity Type Details
dog
(Canis familiaris)
Mammalia -- 34
  • 100 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia ptr-let-7a-1 34
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia bta-let-7a-1 34
  • 97 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 34
  • 89 (a)
ManyToMany
oppossum
(Monodelphis domestica)
Mammalia mdo-let-7a-1 34
  • 86 (a)
ManyToMany
mouse
(Mus musculus)
Mammalia Mirlet7a-1 34
  • 80 (a)
ManyToMany
chicken
(Gallus gallus)
Aves gga-let-7k 34
  • 75 (a)
ManyToMany
lizard
(Anolis carolinensis)
Reptilia aca-let-7a 34
  • 91 (a)
ManyToMany
-- 34
  • 76 (a)
ManyToMany
aca-let-7e 34
  • 65 (a)
ManyToMany
zebrafish
(Danio rerio)
Actinopterygii CR354430.2 34
  • 67 (a)
ManyToMany
dre-let-7a-3 34
  • 67 (a)
ManyToMany
dre-let-7e 34
  • 62 (a)
ManyToMany
Species where no ortholog for MIRLET7A1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for MIRLET7A1 Gene

ENSEMBL:
Gene Tree for MIRLET7A1 (if available)
TreeFam:
Gene Tree for MIRLET7A1 (if available)

Paralogs for MIRLET7A1 Gene

No data available for Paralogs for MIRLET7A1 Gene

Variants for MIRLET7A1 Gene

Sequence variations from dbSNP and Humsavar for MIRLET7A1 Gene

SNP ID Clin Chr 09 pos Sequence Context AA Info Type
rs1001069410 -- 94,174,436(+) CCTCT(C/T)TGCTT upstream-variant-2KB
rs1001242486 -- 94,174,454(+) AGGTT(A/G)AGGGG upstream-variant-2KB
rs1001589170 -- 94,174,757(+) TTCTC(C/T)GCATC upstream-variant-2KB
rs1002261112 -- 94,176,065(+) AGGCG(G/T)TCTGA downstream-variant-500B, upstream-variant-2KB
rs1002305969 -- 94,175,091(+) TTATA(C/T)TGAGC upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for MIRLET7A1 Gene

Variant ID Type Subtype PubMed ID
nsv831655 CNV gain 17160897

Relevant External Links for MIRLET7A1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MIRLET7A1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Variation tolerance for MIRLET7A1 Gene

Disorders for MIRLET7A1 Gene

Relevant External Links for MIRLET7A1

Genetic Association Database (GAD)
MIRLET7A1
Human Genome Epidemiology (HuGE) Navigator
MIRLET7A1
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
MIRLET7A1

No disorders were found for MIRLET7A1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MIRLET7A1 Gene

Publications for MIRLET7A1 Gene

  1. Novel genetic variants in miR-191 gene and familial ovarian cancer. (PMID: 20167074) Shen J … Zhao H (BMC cancer 2010) 3 45 60
  2. XIAP 3'-untranslated region serves as a competitor for HMGA2 by arresting endogenous let-7a-5p in human hepatocellular carcinoma. (PMID: 28691642) Wu WY … Wu ZS (Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine 2017) 3 60
  3. Multi-domain utilization by TUT4 and TUT7 in control of let-7 biogenesis. (PMID: 28671666) Faehnle CR … Joshua-Tor L (Nature structural & molecular biology 2017) 3 60
  4. Effects of long non-coding RNA H19 and microRNA let7a expression on thyroid cancer prognosis. (PMID: 28655518) Liu N … Fan QY (Experimental and molecular pathology 2017) 3 60
  5. Let-7a Inhibits T-Cell Proliferation and IFN-γ Secretion by Down-Regulating STAT3 Expression in Patients with Psoriasis. (PMID: 28494466) Hu XP … Yu B (Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology 2017) 3 60

Products for MIRLET7A1 Gene

Sources for MIRLET7A1 Gene

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