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Aliases for MIRLET7A1 Gene

Subcategory (RNA class) for MIRLET7A1 Gene

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Quality Score for this RNA gene is

3

Aliases for MIRLET7A1 Gene

  • MicroRNA Let-7a-1 2 3
  • MIRNLET7A1 3 6
  • LET7A1 3 6
  • Hsa-Let-7a-1 3
  • Let-7a-1 3

External Ids for MIRLET7A1 Gene

ORGUL Members for MIRLET7A1 Gene

Previous HGNC Symbols for MIRLET7A1 Gene

  • MIRNLET7A1

Previous GeneCards Identifiers for MIRLET7A1 Gene

  • GC09P095981
  • GC09P096938

Summaries for MIRLET7A1 Gene

Entrez Gene Summary for MIRLET7A1 Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIRLET7A1 Gene

MIRLET7A1 (MicroRNA Let-7a-1) is an RNA Gene, and is affiliated with the undefined RNA class. Diseases associated with MIRLET7A1 include endometrial adenocarcinoma and myelodysplastic syndrome. Among its related pathways are MicroRNAs in cancer and miRNAs involved in DDR.

No data available for UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MIRLET7A1 Gene

Genomics for MIRLET7A1 Gene

Genomic Location for MIRLET7A1 Gene

Start:
94,175,952 bp from pter
End:
94,176,043 bp from pter
Size:
92 bases
Orientation:
Plus strand

Genomic View for MIRLET7A1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for MIRLET7A1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIRLET7A1 Gene

No data available for Regulatory Elements for MIRLET7A1 Gene

Proteins for MIRLET7A1 Gene

Post-translational modifications for MIRLET7A1 Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIRLET7A1 Gene

Domains for MIRLET7A1 Gene

Gene Families for MIRLET7A1 Gene

HGNC:
  • MIR :ncRNAs / Micro RNAs

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with MIRLET7A1: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for MIRLET7A1 Gene

Function for MIRLET7A1 Gene

Animal Model Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for MIRLET7A1 Gene

Localization for MIRLET7A1 Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS and Gene Ontology (GO) - Cellular Components for MIRLET7A1 Gene

Pathways for MIRLET7A1 Gene

genes like me logo Genes that share pathways with MIRLET7A1: view

Pathways by source for MIRLET7A1 Gene

1 BioSystems pathway for MIRLET7A1 Gene
1 KEGG pathway for MIRLET7A1 Gene

Interacting Proteins for MIRLET7A1 Gene

Gene Ontology (GO) - Biological Process for MIRLET7A1 Gene

None

Transcripts for MIRLET7A1 Gene

mRNA/cDNA for MIRLET7A1 Gene

(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

miRNA Products

  • QIAGEN qRT-PCR Assays for microRNAs that regulate MIRLET7A1
    • Block miRNA regulation of MIRLET7A1 using miScript Target Protectors

    Inhibitory RNA Products

    • Predesigned siRNA for gene silencing in human,mouse,rat for MIRLET7A1

    Primer Products

    Flow Cytometry Products

    Alternative Splicing Database (ASD) splice patterns (SP) for MIRLET7A1 Gene

    No ASD Table

    Relevant External Links for MIRLET7A1 Gene

    GeneLoc Exon Structure for
    MIRLET7A1
    ECgene alternative splicing isoforms for
    MIRLET7A1

    Expression for MIRLET7A1 Gene

    mRNA expression in normal human tissues for MIRLET7A1 Gene

    genes like me logo Genes that share expressions with MIRLET7A1: view

    In Situ Assay Products

    No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein expression and mRNA Expression by UniProt/SwissProt for MIRLET7A1 Gene

    Orthologs for MIRLET7A1 Gene

    This gene was present in the common ancestor of chordates.

    Orthologs for MIRLET7A1 Gene

    Organism Taxonomy Gene Similarity Type Details
    chimpanzee
    (Pan troglodytes)
    Mammalia ptr-let-7a-1 36
    • 100 (a)
    OneToOne
    cow
    (Bos Taurus)
    Mammalia bta-let-7a-1 36
    • 97 (a)
    OneToOne
    dog
    (Canis familiaris)
    Mammalia -- 36
    • 100 (a)
    OneToOne
    mouse
    (Mus musculus)
    Mammalia Mirlet7a-1 36
    • 80 (a)
    ManyToMany
    oppossum
    (Monodelphis domestica)
    Mammalia mdo-let-7a-1 36
    • 86 (a)
    ManyToMany
    platypus
    (Ornithorhynchus anatinus)
    Mammalia -- 36
    • 89 (a)
    ManyToMany
    chicken
    (Gallus gallus)
    Aves gga-let-7k 36
    • 75 (a)
    ManyToMany
    lizard
    (Anolis carolinensis)
    Reptilia -- 36
    • 76 (a)
    ManyToMany
    aca-let-7a 36
    • 91 (a)
    ManyToMany
    aca-let-7e 36
    • 65 (a)
    ManyToMany
    zebrafish
    (Danio rerio)
    Actinopterygii CR354430.2 36
    • 67 (a)
    ManyToMany
    dre-let-7a-3 36
    • 67 (a)
    ManyToMany
    dre-let-7e 36
    • 62 (a)
    ManyToMany
    Species with no ortholog for MIRLET7A1:
    • A. gosspyii yeast (Ashbya gossypii)
    • Actinobacteria (Mycobacterium tuberculosis)
    • African clawed frog (Xenopus laevis)
    • African malaria mosquito (Anopheles gambiae)
    • Alicante grape (Vitis vinifera)
    • alpha proteobacteria (Wolbachia pipientis)
    • amoeba (Dictyostelium discoideum)
    • Archea (Pyrococcus horikoshii)
    • baker's yeast (Saccharomyces cerevisiae)
    • barley (Hordeum vulgare)
    • beta proteobacteria (Neisseria meningitidis)
    • bread mold (Neurospora crassa)
    • Chromalveolata (Phytophthora infestans)
    • common water flea (Daphnia pulex)
    • corn (Zea mays)
    • E. coli (Escherichia coli)
    • filamentous fungi (Aspergillus nidulans)
    • Firmicute bacteria (Streptococcus pneumoniae)
    • fission yeast (Schizosaccharomyces pombe)
    • fruit fly (Drosophila melanogaster)
    • green algae (Chlamydomonas reinhardtii)
    • honey bee (Apis mellifera)
    • K. lactis yeast (Kluyveromyces lactis)
    • loblloly pine (Pinus taeda)
    • malaria parasite (Plasmodium falciparum)
    • medicago trunc (Medicago Truncatula)
    • moss (Physcomitrella patens)
    • orangutan (Pongo pygmaeus)
    • pig (Sus scrofa)
    • rainbow trout (Oncorhynchus mykiss)
    • rat (Rattus norvegicus)
    • rice (Oryza sativa)
    • rice blast fungus (Magnaporthe grisea)
    • schistosome parasite (Schistosoma mansoni)
    • sea anemone (Nematostella vectensis)
    • sea squirt (Ciona intestinalis)
    • sea squirt (Ciona savignyi)
    • sea urchin (Strongylocentrotus purpuratus)
    • sorghum (Sorghum bicolor)
    • soybean (Glycine max)
    • stem rust fungus (Puccinia graminis)
    • sugarcane (Saccharum officinarum)
    • thale cress (Arabidopsis thaliana)
    • tomato (Lycopersicon esculentum)
    • toxoplasmosis (Toxoplasma gondii)
    • Trichoplax (Trichoplax adhaerens)
    • tropical clawed frog (Silurana tropicalis)
    • wheat (Triticum aestivum)
    • worm (Caenorhabditis elegans)

    Evolution for MIRLET7A1 Gene

    ENSEMBL:
    Gene Tree for MIRLET7A1 (if available)
    TreeFam:
    Gene Tree for MIRLET7A1 (if available)

    Paralogs for MIRLET7A1 Gene

    No data available for Paralogs for MIRLET7A1 Gene

    Variants for MIRLET7A1 Gene

    Sequence variations from dbSNP and Humsavar for MIRLET7A1 Gene

    SNP ID Clin Chr 09 pos Sequence Context AA Info Type MAF
    rs7865471 -- 94,174,340(+) gtcca(A/C)accct upstream-variant-2KB
    rs114051005 -- 94,174,113(+) GGTTT(C/T)ACAAC upstream-variant-2KB
    rs114650747 -- 94,174,183(+) TATCA(C/G)TGGTT upstream-variant-2KB
    rs139812691 -- 94,174,333(+) CAGAG(C/T)TGTCC upstream-variant-2KB
    rs142183761 -- 94,174,039(+) AAACA(C/T)GTAAG upstream-variant-2KB

    Structural Variations from Database of Genomic Variants (DGV) for MIRLET7A1 Gene

    Variant ID Type Subtype PubMed ID
    nsv831655 CNV Gain 17160897

    Relevant External Links for MIRLET7A1 Gene

    HapMap Linkage Disequilibrium report
    MIRLET7A1

    No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MIRLET7A1 Gene

    Disorders for MIRLET7A1 Gene

    MalaCards: The human disease database

    MalaCards: The human disease database. (2) Diseases for MIRLET7A1 Gene including...

    Search for MIRLET7A1 Gene in MalaCards »

    Relevant External Links for MIRLET7A1

    Genetic Association Database (GAD)
    MIRLET7A1
    Human Genome Epidemiology (HuGE) Navigator
    MIRLET7A1
    genes like me logo Genes that share disorders with MIRLET7A1: view

    No data available for UniProtKB/Swiss-Prot for MIRLET7A1 Gene

    Publications for MIRLET7A1 Gene

    1. Novel genetic variants in miR-191 gene and familial ovarian cancer. (PMID: 20167074) Shen J. … Zhao H. (BMC Cancer 2010) 3 48
    2. MicroRNA let-7a inhibits proliferation of human prostate cancer cells in vitro and in vivo by targeting E2F2 and CCND2. (PMID: 20418948) Dong Q. … Wang H. (PLoS ONE 2010) 3
    3. Mutations in the let-7 binding site - a mechanism of RAS activation in juvenile myelomonocytic leukemia? (PMID: 20460640) Steinemann D. … Schlegelberger B. (Haematologica 2010) 3
    4. MicroRNA-98 and let-7 regulate expression of suppressor of cytokine signaling 4 in biliary epithelial cells in response to Cryptosporidium parvum infection. (PMID: 20486857) Hu G. … Chen X.M. (J. Infect. Dis. 2010) 3
    5. Let-7 microRNA inhibits the proliferation of human glioblastoma cells. (PMID: 20607356) Lee S.T. … Roh J.K. (J. Neurooncol. 2011) 3

    Products for MIRLET7A1 Gene

    Sources for MIRLET7A1 Gene

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