MIRLET7A1 Gene
RNA gene GIFtS: 21
GCID: GC09P096938
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microRNA let-7a-1
(Previous symbol: MIRNLET7A1)
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Aliases
for MIRLET7A1 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
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Subcategory (RNA class): miRNA
Quality score for this RNA gene is 3
| Aliases |
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| MicroRNA Let-7a-11 2 | | MIRNLET7A11 2 5 | | Let-7a-11 | | LET7A12 5 | | Hsa-Let-7a-11 |
| External Ids: | HGNC: 314761 | Entrez Gene: 4068812 | Ensembl: ENSG000001991657 | OMIM: 6053865 |
Export aliases for MIRLET7A1 gene to outside databasesPrevious GC identifer: GC09P095981
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Summaries
for MIRLET7A1 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
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Entrez Gene summary for MIRLET7A1:
microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of geneexpression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribedby RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be eitherprotein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce anapproximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicerribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporatedinto a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with themiRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeqrepresents the predicted microRNA stem-loop. (provided by RefSeq, Sep 2009)
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Genomic Views
for MIRLET7A1 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| Regulatory elements:
 Search SABiosciences Regulatory transcription factor binding sites for MIRLET7A1
Other transcription factors
Search SABiosciences Chromatin IP Primers for MIRLET7A1
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat MIRLET7A1 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 9q22.32 Ensembl cytogenetic band: 9q22.32 HGNC cytogenetic band: 9q22.32MIRLET7A1 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 9 GeneLoc Exon Structure GeneLoc location for GC09P096938: view genomic region (via miRBase)
(about GC identifiers)
Start:
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96,938,234 bp from pter |
End:
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96,938,325 bp from pter |
Size:
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92 bases |
Orientation:
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plus strand |
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Proteins
for MIRLET7A1 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
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UniProtKB: --
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Protein
Domains /
Families
for MIRLET7A1 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
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Function
for MIRLET7A1 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
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Pathways & Interactions
for MIRLET7A1 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
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Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for MIRLET7A1
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Drugs & Compounds
for MIRLET7A1 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
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 Browse Tocris compounds for MIRLET7A1
Search CenterWatch for drugs/clinical trials and news about MIRLET7A1 
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Transcripts
for MIRLET7A1 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
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1 Ensembl transcript including schematic representation, and UCSC links where relevant: ENST00000362295(miRNA)
GeneLoc Exon Structure
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Expression
for MIRLET7A1 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| Expression evidence for MIRLET7A1:none
MIRLET7A1 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: --
About this image SABiosciences Custom PCR Arrays for MIRLET7A1
Primer
Products: |  | Browse OriGene genome-wide validated SYBR primer pairs
Browse OriGene validated miRNA SYBR primer pairs
| | | Search SABiosciences RT2 qPCR
Primer Assays in human, mouse, rat MIRLET7A1 | | | Search QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat MIRLET7A1 | | | Search QIAGEN QuantiFast Probe-based Assays in human, mouse, rat MIRLET7A1 |
Orthologs
for MIRLET7A1 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
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ENSEMBL Gene Tree for MIRLET7A1 (if available)
TreeFam Gene Tree for MIRLET7A1 (if available) |
Paralogs
for MIRLET7A1 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for MIRLET7A1 gene
- MIRLET7B2 MIRLET7C2 MIRLET7I2 MIRLET7A22 MIRLET7F22 MIRLET7D2 MIR982 MIRLET7F12
- MIRLET7G2 MIRLET7A32 MIRLET7E2
MIRLET7A1 for paralogs About GeneDecksing
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Genomic Variants
for MIRLET7A1 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
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| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 9 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
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HapMap Linkage Disequilibrium report for MIRLET7A1 (96938234 - 96938325 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 1 variation for MIRLET7A1
1 CNV: 4645 | SABiosciences Cancer Mutation PCR Assays |
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Disorders
/ Diseases
for MIRLET7A1 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
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MIRLET7A1 for disorders About GeneDecksing
OMIM gene information: 605386
OMIM disorders: --
20/30  diseases for MIRLET7A1 (see all 30): About MalaCardsdiffuse large b-cell lymphoma b-cell lymphomas pituitary adenoma lipoma
endometrial adenocarcinoma liposarcoma laryngitis leiomyosarcoma
laryngeal cancer cervicitis leiomyoma cervical carcinoma
adenoma colon carcinoma hepatocellular carcinoma cervical cancer
colon cancer periodontitis ovarian cancer gastric cancer
Human Genome Epidemiology (HuGE) Navigator: MIRLET7A1 (1 document)
Export disorders for MIRLET7A1 gene to outside databases
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Publications
for MIRLET7A1 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
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PubMed articles for MIRLET7A1 gene, integrated from 9 sources (see all 65):
(articles sorted by number of sources associating them with MIRLET7A1) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Estrogen receptor-regulated microRNAs contribute to t he BCL2/BAX imbalance in endometrial adenocarcinoma and precancerous lesions. (PubMed id 22014978)1 Zhang R....Wei Z. (2012)
- Investigation and identification of let-7a related fun ctional proteins in gastric carcinoma by proteomics. (PubMed id 22596182)1 Zhu Y....Liu Z. (2012)
- High let-7a microRNA levels in KRAS-mutated colorectal carcinomas may rescue anti-EGFR therapy effects in patients with chemotherapy-r efractory metastatic disease. (PubMed id 22584434)1 Ruzzo A....Magnani M. (2012)
- Senescence is an endogenous trigger for microRNA-direc ted transcriptional gene silencing in human cells. (PubMed id 22366686)1 Benhamed M....Bischof O. (2012)
- Downregulation of HMGA-targeting microRNAs has a criti cal role in human pituitary tumorigenesis. (PubMed id 22139073)1 Palmieri D....Fusco A. (2012)
- Let-7a down-regulation plays a role in thyroid neoplas ias of follicular histotype affecting cell adhesion and migration through its ab ility to target the FXYD5 (Dysadherin) gene. (PubMed id 22965940)1 Colamaio M....Fusco A. (2012)
- NIRF is frequently upregulated in colorectal cancer a nd its oncogenicity can be suppressed by let-7a microRNA. (PubMed id 22018986)1 Wang F....Qin H. (2012)
- Structural basis of pre-let-7 miRNA recognition by the zinc knuckles of pluripotency factor Lin28. (PubMed id 22157959)1 Loughlin F.E....Allain F.H. (2012)
- Role of microRNA let-7 and effect to HMGA2 in esophage al squamous cell carcinoma. (PubMed id 21598109)1 Liu Q....Lu X.M. (2012)
- Hsa-let-7a functions as a tumor suppressor in renal ce ll carcinoma cell lines by targeting c-myc. (PubMed id 22155254)1 Liu Y....Fan J. (2012)
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External Searches for MIRLET7A1 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
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Genome Databases showing MIRLET7A1 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
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Other Databases showing MIRLET7A1 gene
(According to HUGE)
About This Section
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Specialized Databases showing MIRLET7A1 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
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| Name | Description |
| PharmGKB entry for MIRLET7A1 | Pharmacogenomics, SNPs, Pathways |
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About This Section
| Patent Information for MIRLET7A1 gene:
Search GeneIP for patents involving MIRLET7A1
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
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Products
for MIRLET7A1 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
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|  | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat MIRLET7A1 | | | Search QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing MIRLET7A1 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat MIRLET7A1 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat MIRLET7A1 | | | Search QIAGEN QuantiFast Probe-based Assays in human, mouse, rat MIRLET7A1 | | | Search QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat MIRLET7A1 |
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 | | | | |  |  |  | | | | | Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat MIRLET7A1 |
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Incrementals: 21 Mar 2013 , 15 Apr 2013 , 26 Apr 2013
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