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Aliases for MIR99B Gene

Subcategory (RNA class) for MIR99B Gene

miRNA

Quality Score for this RNA gene is

3

Aliases for MIR99B Gene

  • MicroRNA 99b 2 3 5
  • Hsa-Mir-99b 3
  • Mir-99b 3
  • MIRN99B 3

External Ids for MIR99B Gene

ORGUL Members for MIR99B Gene

Previous HGNC Symbols for MIR99B Gene

  • MIRN99B

Previous GeneCards Identifiers for MIR99B Gene

  • GC19P056922
  • GC19P056926
  • GC19P052195

Summaries for MIR99B Gene

Entrez Gene Summary for MIR99B Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR99B Gene

MIR99B (MicroRNA 99b) is an RNA Gene, and is affiliated with the miRNA class.

No data available for UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MIR99B Gene

Genomics for MIR99B Gene

Regulatory Elements for MIR99B Gene

Enhancers for MIR99B Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH19F051545 1.5 FANTOM5 Ensembl ENCODE 10.5 -142.8 -142798 8.1 HDGF PKNOX1 ARNT MLX CREB3L1 ZFP64 ARID4B SIN3A DMAP1 YY1 ZNF175 SIGLEC14 SIGLEC6 SIGLEC5 SIGLEC8 CEACAM18 ENSG00000269102 SIGLEC12 RPL7P51 LOC100419835
GH19F051438 0.6 Ensembl ENCODE 9.9 -253.8 -253828 0.8 CTCF PKNOX1 TEAD4 CEBPB TRIM22 MIER2 CEBPG REST RAD21 IKZF1 SIGLEC12 CEACAM18 VSIG10L SIGLEC14 SIGLEC5 RPL7P51 CLDND2 NKG7 ETFB MIR125A
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around MIR99B on UCSC Golden Path with GeneCards custom track

Genomic Location for MIR99B Gene

Chromosome:
19
Start:
51,692,612 bp from pter
End:
51,692,681 bp from pter
Size:
70 bases
Orientation:
Plus strand

Genomic View for MIR99B Gene

Genes around MIR99B on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MIR99B Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR99B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR99B Gene

Proteins for MIR99B Gene

Post-translational modifications for MIR99B Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR99B Gene

Domains & Families for MIR99B Gene

Gene Families for MIR99B Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with MIR99B: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for MIR99B Gene

Function for MIR99B Gene

Animal Model Products

miRNA Products

Clone Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR99B Gene

Localization for MIR99B Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS and Gene Ontology (GO) - Cellular Components for MIR99B Gene

Pathways & Interactions for MIR99B Gene

SuperPathways for MIR99B Gene

No Data Available

Interacting Proteins for MIR99B Gene

Gene Ontology (GO) - Biological Process for MIR99B Gene

None

No data available for Pathways by source and SIGNOR curated interactions for MIR99B Gene

Transcripts for MIR99B Gene

mRNA/cDNA for MIR99B Gene

(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

miRNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for MIR99B Gene

No ASD Table

Relevant External Links for MIR99B Gene

GeneLoc Exon Structure for
MIR99B
ECgene alternative splicing isoforms for
MIR99B

Expression for MIR99B Gene

NURSA nuclear receptor signaling pathways regulating expression of MIR99B Gene:

MIR99B
No Expression Related Data Available

No data available for mRNA expression in normal human tissues , mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners and mRNA Expression by UniProt/SwissProt for MIR99B Gene

Orthologs for MIR99B Gene

This gene was present in the common ancestor of chordates.

Orthologs for MIR99B Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia bta-mir-99b 35
  • 100 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Mir99b 35
  • 100 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia ptr-mir-99b 35
  • 100 (a)
OneToOne
dog
(Canis familiaris)
Mammalia cfa-mir-99b 35
  • 95 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia oan-mir-100 35
  • 60 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia mdo-mir-10a 35
  • 42 (a)
ManyToMany
chicken
(Gallus gallus)
Aves gga-mir-100 35
  • 59 (a)
ManyToMany
lizard
(Anolis carolinensis)
Reptilia aca-mir-99b 35
  • 60 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii dre-mir-10d 35
  • 28 (a)
ManyToMany
Species where no ortholog for MIR99B was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for MIR99B Gene

ENSEMBL:
Gene Tree for MIR99B (if available)
TreeFam:
Gene Tree for MIR99B (if available)

Paralogs for MIR99B Gene

No data available for Paralogs for MIR99B Gene

Variants for MIR99B Gene

Sequence variations from dbSNP and Humsavar for MIR99B Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type
rs111708183 -- 51,693,116(+) AGGTC(G/T)CTGCC intron-variant, nc-transcript-variant, downstream-variant-500B, upstream-variant-2KB, utr-variant-5-prime
rs113906081 -- 51,691,202(+) AGAAA(-/AG)AGAGA intron-variant, upstream-variant-2KB
rs116185360 -- 51,691,939(+) CTCAG(A/C)CCCCT intron-variant, upstream-variant-2KB, utr-variant-5-prime
rs11668874 -- 51,691,696(+) ACTGC(C/G)AGAAA intron-variant, upstream-variant-2KB
rs138326974 -- 51,692,540(+) GATGA(A/G)GAAGG intron-variant, upstream-variant-2KB, utr-variant-5-prime

Structural Variations from Database of Genomic Variants (DGV) for MIR99B Gene

Variant ID Type Subtype PubMed ID
esv2758767 CNV gain+loss 17122850
nsv1140251 OTHER inversion 24896259
nsv953608 CNV deletion 24416366
nsv9742 CNV gain+loss 18304495

Relevant External Links for MIR99B Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MIR99B

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Variation tolerance for MIR99B Gene

Disorders for MIR99B Gene

Relevant External Links for MIR99B

Human Genome Epidemiology (HuGE) Navigator
MIR99B
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
MIR99B

No disorders were found for MIR99B Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MIR99B Gene

Publications for MIR99B Gene

  1. miR-99b promotes metastasis of hepatocellular carcinoma through inhibition of claudinA 11 expression and may serve as a prognostic marker. (PMID: 26134929) Yang J. … Wang Z. (Oncol. Rep. 2015) 3 64
  2. miRNA-99b-5p suppresses liver metastasis of colorectal cancer by down-regulating mTOR. (PMID: 26259252) Li W. … Li J. (Oncotarget 2015) 3 64
  3. miR-99b suppresses IGF-1R expression and contributes to inhibition of cell proliferation in human epidermal keratinocytes. (PMID: 26297545) Li J. … Wang J. (Biomed. Pharmacother. 2015) 3 64
  4. miR-99a and -99b inhibit cervical cancer cell proliferation and invasion by targeting mTOR signaling pathway. (PMID: 24668416) Wang L. … Li M. (Med. Oncol. 2014) 3 64
  5. MicroRNA-99 family targets AKT/mTOR signaling pathway in dermal wound healing. (PMID: 23724047) Jin Y. … Zhou X. (PLoS ONE 2013) 3 64

Products for MIR99B Gene

Sources for MIR99B Gene

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