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Aliases for MIR99A Gene

Subcategory (RNA class) for MIR99A Gene

miRNA

Quality Score for this RNA gene is

3

Aliases for MIR99A Gene

  • MicroRNA 99a 2 3 5
  • Hsa-Mir-99a 3
  • Mir-99a 3
  • MIRN99A 3

External Ids for MIR99A Gene

Previous HGNC Symbols for MIR99A Gene

  • MIRN99A

Previous GeneCards Identifiers for MIR99A Gene

  • GC21P016841
  • GC21P017911

Summaries for MIR99A Gene

Entrez Gene Summary for MIR99A Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR99A Gene

MIR99A (MicroRNA 99a) is an RNA Gene, and is affiliated with the miRNA class. Among its related pathways are MicroRNAs in cancer.

No data available for UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MIR99A Gene

Genomics for MIR99A Gene

Regulatory Elements for MIR99A Gene

Enhancers for MIR99A Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH21F016563 1.3 Ensembl ENCODE 11.7 +24.9 24862 1.2 SOX13 TEAD4 MAX RAD21 RFX5 TEAD3 RCOR1 MAFK TCF7L2 CHD2 MIR99A MIRLET7C ENSG00000269950 PIR42144 GC21P016551
GH21F016578 2.3 VISTA Ensembl ENCODE 11.5 +40.9 40927 2.6 MAFK MIR99A MIRLET7C ENSG00000269950 PIR42144 GC21P016551
GH21F016573 1.3 Ensembl ENCODE 11.5 +34.8 34765 1.6 MIR99A MIRLET7C ENSG00000269950 GC21P016551 PIR42144
GH21F016570 0.7 ENCODE 11.5 +31.3 31339 0.4 MAFF CEBPB NFE2 EP300 MAFK NFE2L2 MIR99A MIRLET7C ENSG00000269950 GC21P016551 PIR42144
GH21F016572 0.6 ENCODE 11.5 +33.1 33147 0.2 ZNF680 MIR99A MIRLET7C ENSG00000269950 GC21P016551 PIR42144
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around MIR99A on UCSC Golden Path with GeneCards custom track

Genomic Location for MIR99A Gene

Chromosome:
21
Start:
16,539,089 bp from pter
End:
16,539,169 bp from pter
Size:
81 bases
Orientation:
Plus strand

Genomic View for MIR99A Gene

Genes around MIR99A on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MIR99A Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR99A Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR99A Gene

Proteins for MIR99A Gene

Post-translational modifications for MIR99A Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR99A Gene

Domains & Families for MIR99A Gene

Gene Families for MIR99A Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with MIR99A: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for MIR99A Gene

Function for MIR99A Gene

Animal Model Products

miRNA Products

Clone Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR99A Gene

Localization for MIR99A Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS and Gene Ontology (GO) - Cellular Components for MIR99A Gene

Pathways & Interactions for MIR99A Gene

SuperPathways for MIR99A Gene

SuperPathway Contained pathways
1 MicroRNAs in cancer
genes like me logo Genes that share pathways with MIR99A: view

Pathways by source for MIR99A Gene

1 KEGG pathway for MIR99A Gene

Interacting Proteins for MIR99A Gene

Gene Ontology (GO) - Biological Process for MIR99A Gene

None

No data available for SIGNOR curated interactions for MIR99A Gene

Transcripts for MIR99A Gene

mRNA/cDNA for MIR99A Gene

(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

miRNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for MIR99A Gene

No ASD Table

Relevant External Links for MIR99A Gene

GeneLoc Exon Structure for
MIR99A
ECgene alternative splicing isoforms for
MIR99A

Expression for MIR99A Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for MIR99A Gene

NURSA nuclear receptor signaling pathways regulating expression of MIR99A Gene:

MIR99A
genes like me logo Genes that share expression patterns with MIR99A: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners and mRNA Expression by UniProt/SwissProt for MIR99A Gene

Orthologs for MIR99A Gene

This gene was present in the common ancestor of chordates.

Orthologs for MIR99A Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia bta-mir-99a 35
  • 100 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia ptr-mir-99a 35
  • 100 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Mir99a 35
  • 97 (a)
OneToOne
dog
(Canis familiaris)
Mammalia cfa-mir-99a-1 35
  • 95 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia oan-mir-99 35
  • 72 (a)
OneToOne
chicken
(Gallus gallus)
Aves gga-mir-99a 35
  • 93 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia aca-mir-99a 35
  • 78 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii mir99-2 35
  • 80 (a)
OneToMany
dre-mir-99-1 35
  • 79 (a)
OneToMany
Species where no ortholog for MIR99A was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for MIR99A Gene

ENSEMBL:
Gene Tree for MIR99A (if available)
TreeFam:
Gene Tree for MIR99A (if available)

Paralogs for MIR99A Gene

No data available for Paralogs for MIR99A Gene

Variants for MIR99A Gene

Sequence variations from dbSNP and Humsavar for MIR99A Gene

SNP ID Clin Chr 21 pos Sequence Context AA Info Type
rs10470097 -- 16,538,872(+) AGTTC(A/G)TGAAA intron-variant, upstream-variant-2KB
rs111846070 -- 16,538,131(+) TTAGG(A/G)AATGC intron-variant, upstream-variant-2KB
rs112782413 -- 16,539,314(+) ACAAG(G/T)CAGGC intron-variant, downstream-variant-500B, upstream-variant-2KB
rs113281460 -- 16,537,794(+) GGTCA(G/T)GCTTT intron-variant, upstream-variant-2KB
rs114408919 -- 16,537,551(+) TGTAA(C/T)TGTTG intron-variant, upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for MIR99A Gene

Variant ID Type Subtype PubMed ID
esv2723192 CNV deletion 23290073
esv3893374 CNV loss 25118596

Relevant External Links for MIR99A Gene

Human Gene Mutation Database (HGMD)
MIR99A
SNPedia medical, phenotypic, and genealogical associations of SNPs for
MIR99A

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Variation tolerance for MIR99A Gene

Disorders for MIR99A Gene

Relevant External Links for MIR99A

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
MIR99A

No disorders were found for MIR99A Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MIR99A Gene

Publications for MIR99A Gene

  1. miR-99a suppresses the metastasis of human non-small cell lung cancer cells by targeting AKT1 signaling pathway. (PMID: 25187230) Yu S.H. … Zhang Y.M. (J. Cell. Biochem. 2015) 3 64
  2. Systematic analysis of berberine-induced signaling pathway between miRNA clusters and mRNAs and identification of mir-99a a81 125b cluster function by seed-targeting inhibitors in multiple myeloma cells. (PMID: 25826415) Feng M. … Fei J. (RNA Biol 2015) 3 64
  3. Circulating microRNAs as novel prognosis biomarkers for head and neck squamous cell carcinoma. (PMID: 25950115) Hou B. … Takeuchi K. (Cancer Biol. Ther. 2015) 3 64
  4. MiR-99a Inhibits Cell Proliferation and Tumorigenesis through Targeting mTOR in Human Anaplastic Thyroid Cancer. (PMID: 26163618) Huang H.G. … Jian B. (Asian Pac. J. Cancer Prev. 2015) 3 64
  5. microRNAa8999a inhibits cell proliferation, colony formation ability, migration and invasion by targeting fibroblast growth factor receptor 3 in prostate cancer. (PMID: 25352177) Wu D. … Zhou J. (Mol Med Rep 2015) 3 64

Products for MIR99A Gene

Sources for MIR99A Gene

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