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Aliases for MIR98 Gene

Subcategory (RNA class) for MIR98 Gene

miRNA

Quality Score for this RNA gene is

3

Aliases for MIR98 Gene

  • MicroRNA 98 2 3 5
  • Hsa-Mir-98 3
  • MiR-98 3
  • MIRN98 3

External Ids for MIR98 Gene

Previous HGNC Symbols for MIR98 Gene

  • MIRN98

Previous GeneCards Identifiers for MIR98 Gene

  • GC0XM053601
  • GC0XM053589
  • GC0XM053592
  • GC0XM053561
  • GC0XM053562
  • GC0XM053563
  • GC0XM053565
  • GC0XM053566

Summaries for MIR98 Gene

Entrez Gene Summary for MIR98 Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR98 Gene

MIR98 (MicroRNA 98) is an RNA Gene, and is affiliated with the miRNA class. Among its related pathways are Toll-like Receptor Signaling Pathway.

No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MIR98 Gene

Genomics for MIR98 Gene

Genomic Location for MIR98 Gene

Chromosome:
X
Start:
53,556,223 bp from pter
End:
53,556,341 bp from pter
Size:
119 bases
Orientation:
Minus strand

Genomic View for MIR98 Gene

Genes around MIR98 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MIR98 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR98 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR98 Gene

No data available for Regulatory Elements for MIR98 Gene

Proteins for MIR98 Gene

Post-translational modifications for MIR98 Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR98 Gene

Domains & Families for MIR98 Gene

Gene Families for MIR98 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with MIR98: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for MIR98 Gene

Function for MIR98 Gene

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR98 Gene

Localization for MIR98 Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS and Gene Ontology (GO) - Cellular Components for MIR98 Gene

Pathways & Interactions for MIR98 Gene

genes like me logo Genes that share pathways with MIR98: view

Pathways by source for MIR98 Gene

1 BioSystems pathway for MIR98 Gene

Interacting Proteins for MIR98 Gene

Gene Ontology (GO) - Biological Process for MIR98 Gene

None

No data available for SIGNOR curated interactions for MIR98 Gene

Transcripts for MIR98 Gene

mRNA/cDNA for MIR98 Gene

(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Alternative Splicing Database (ASD) splice patterns (SP) for MIR98 Gene

No ASD Table

Relevant External Links for MIR98 Gene

GeneLoc Exon Structure for
MIR98
ECgene alternative splicing isoforms for
MIR98

Expression for MIR98 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for MIR98 Gene

NURSA nuclear receptor signaling pathways regulating expression of MIR98 Gene:

MIR98
genes like me logo Genes that share expression patterns with MIR98: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for MIR98 Gene

Orthologs for MIR98 Gene

This gene was present in the common ancestor of chordates.

Orthologs for MIR98 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ptr-mir-98 35
  • 100 (a)
OneToOne
dog
(Canis familiaris)
Mammalia cfa-mir-98 35
  • 96 (a)
OneToOne
cow
(Bos Taurus)
Mammalia bta-mir-98 35
  • 94 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Mir98 35
  • 81 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 35
  • 56 (a)
OneToMany
oan-mir-98 35
  • 55 (a)
OneToMany
chicken
(Gallus gallus)
Aves gga-let-7a-3 35
  • 74 (a)
ManyToMany
lizard
(Anolis carolinensis)
Reptilia aca-mir-98 35
  • 88 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii dre-let-7h 35
  • 62 (a)
OneToOne
Species where no ortholog for MIR98 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for MIR98 Gene

ENSEMBL:
Gene Tree for MIR98 (if available)
TreeFam:
Gene Tree for MIR98 (if available)

Paralogs for MIR98 Gene

No data available for Paralogs for MIR98 Gene

Variants for MIR98 Gene

Sequence variations from dbSNP and Humsavar for MIR98 Gene

SNP ID Clin Chr 0X pos Sequence Context AA Info Type
rs1003242406 -- 53,558,329(+) GGGCG(A/G)CTAAG intron-variant, upstream-variant-2KB
rs1003462106 -- 53,557,720(+) AGCAA(G/T)AATTT intron-variant, upstream-variant-2KB
rs1005715069 -- 53,557,551(+) TGCTT(C/T)GGCCA intron-variant, upstream-variant-2KB
rs1009827205 -- 53,556,640(+) ACATA(C/T)GGCAG intron-variant, upstream-variant-2KB
rs1015898204 -- 53,556,800(+) TAGCC(A/G)TGTAA intron-variant, downstream-variant-500B, upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for MIR98 Gene

Variant ID Type Subtype PubMed ID
esv2740175 CNV deletion 23290073
esv3576879 CNV gain 25503493
nsv435891 CNV deletion 17901297

Relevant External Links for MIR98 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MIR98

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Variation tolerance for MIR98 Gene

Disorders for MIR98 Gene

Relevant External Links for MIR98

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
MIR98

No disorders were found for MIR98 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MIR98 Gene

Publications for MIR98 Gene

  1. miR-98 inhibits hepatocellular carcinoma cell proliferation via targeting EZH2 and suppressing Wnt/I^-catenin signaling pathway. (PMID: 27890434) Zhang J.J. … Wang C.Y. (Biomed. Pharmacother. 2017) 3 64
  2. Peroxisome Proliferator-Activated Receptor I^ and microRNA 98 in Hypoxia-Induced Endothelin-1 Signaling. (PMID: 26098770) Kang B.Y. … Hart C.M. (Am. J. Respir. Cell Mol. Biol. 2016) 3 64
  3. Dysregulated miR-98 Contributes to Extracellular Matrix Degradation by Targeting IL-6/STAT3 Signaling Pathway in Human Intervertebral Disc Degeneration. (PMID: 26587789) Ji M.L. … Wang C. (J. Bone Miner. Res. 2016) 3 64
  4. MicroRNA-98 suppresses cell proliferation, migration and invasion by targeting collagen triple helix repeat containing 1 in hepatocellular carcinoma. (PMID: 26846175) Wang C.Y. … Ren X.Q. (Mol Med Rep 2016) 3 64
  5. Expression of miR-98 in myocarditis and its influence on transcription of the FAS/FASL gene pair. (PMID: 27323110) Zhang B.Y. … Jin Z. (Genet. Mol. Res. 2016) 3 64

Products for MIR98 Gene

Sources for MIR98 Gene

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