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Aliases for MIR96 Gene

Subcategory (RNA class) for MIR96 Gene


Quality Score for this RNA gene is


Aliases for MIR96 Gene

  • MicroRNA 96 2 3
  • DFNA50 3 6
  • MIRN96 3 6
  • Deafness, Autosomal Dominant 50 2
  • Hsa-Mir-96 3
  • MiRNA96 3
  • MiR-96 3

External Ids for MIR96 Gene

Previous HGNC Symbols for MIR96 Gene

  • MIRN96
  • DFNA50

Previous GeneCards Identifiers for MIR96 Gene

  • GC07M129203
  • GC07M129414

Summaries for MIR96 Gene

Entrez Gene Summary for MIR96 Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. The microRNA encoded by this gene has been shown to down-regulate production of FOXO1, FOXO3, and microphthalmia-associated transcription factor-M, resulting in metastasis of certain tumors. Also, point mutations in the seed region of this microRNA are a cause of autosomal dominant, progressive hearing loss. [provided by RefSeq, Mar 2010]

GeneCards Summary for MIR96 Gene

MIR96 (MicroRNA 96) is an RNA Gene, and is affiliated with the miRNA class. Diseases associated with MIR96 include deafness, autosomal dominant 50 and dfna50 nonsyndromic hearing loss and deafness. Among its related pathways are MicroRNAs in cancer.

No data available for UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MIR96 Gene

Genomics for MIR96 Gene

Genomic Location for MIR96 Gene

129,774,692 bp from pter
129,774,769 bp from pter
78 bases
Minus strand

Genomic View for MIR96 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for MIR96 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR96 Gene

ORGUL Member Location for MIR96 Gene

ORGUL Member Location for MIR96 gene

No data available for Regulatory Elements for MIR96 Gene

Proteins for MIR96 Gene

Post-translational modifications for MIR96 Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR96 Gene

Domains for MIR96 Gene

Gene Families for MIR96 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with MIR96: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for MIR96 Gene

Function for MIR96 Gene

genes like me logo Genes that share phenotypes with MIR96: view

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR96 Gene

Localization for MIR96 Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS and Gene Ontology (GO) - Cellular Components for MIR96 Gene

Pathways for MIR96 Gene

SuperPathways for MIR96 Gene

Superpath Contained pathways
1 MicroRNAs in cancer
genes like me logo Genes that share pathways with MIR96: view

Pathways by source for MIR96 Gene

1 KEGG pathway for MIR96 Gene

Interacting Proteins for MIR96 Gene

Gene Ontology (GO) - Biological Process for MIR96 Gene


Transcripts for MIR96 Gene

mRNA/cDNA for MIR96 Gene

(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Alternative Splicing Database (ASD) splice patterns (SP) for MIR96 Gene

No ASD Table

Relevant External Links for MIR96 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for MIR96 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

genes like me logo Genes that share expressions with MIR96: view

Primer Products

In Situ Assay Products

No data available for mRNA expression in normal human tissues , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , mRNA Expression by UniProt/SwissProt and Expression partners for MIR96 Gene

Orthologs for MIR96 Gene

This gene was present in the common ancestor of chordates.

Orthologs for MIR96 Gene

Organism Taxonomy Gene Similarity Type Details
(Mus musculus)
Mammalia Mir96 16
Mir96 36
  • 72 (a)
(Bos Taurus)
Mammalia bta-mir-96 36
  • 75 (a)
(Canis familiaris)
Mammalia cfa-mir-96 36
  • 88 (a)
(Monodelphis domestica)
Mammalia mdo-mir-96 36
  • 75 (a)
(Ornithorhynchus anatinus)
Mammalia oan-mir-96 36
  • 67 (a)
(Pan troglodytes)
Mammalia ptr-mir-96 36
  • 100 (a)
(Gallus gallus)
Aves -- 36
  • 63 (a)
(Danio rerio)
Actinopterygii dre-mir-96 36
  • 50 (a)
Species with no ortholog for MIR96:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for MIR96 Gene

Gene Tree for MIR96 (if available)
Gene Tree for MIR96 (if available)

Paralogs for MIR96 Gene

No data available for Paralogs for MIR96 Gene

Variants for MIR96 Gene

Sequence variations from dbSNP and Humsavar for MIR96 Gene

SNP ID Clin Chr 07 pos Sequence Context AA Info Type MAF
rs568056879 -- 129,774,303(+) AGCCC(A/G)CCTGC downstream-variant-500B
rs564111558 -- 129,774,229(+) TGACC(C/T)ACTCC downstream-variant-500B
rs556223300 -- 129,774,192(+) CCCCA(C/T)TAAGT downstream-variant-500B
rs546714859 -- 129,774,284(+) CCAGG(A/C)TGACC downstream-variant-500B
rs371102517 -- 129,774,294(+) CTCAA(A/G)GGCAG downstream-variant-500B

Structural Variations from Database of Genomic Variants (DGV) for MIR96 Gene

Variant ID Type Subtype PubMed ID
esv23078 CNV Gain 19812545
nsv516024 CNV Gain+Loss 19592680
nsv464721 CNV Loss 19166990

Relevant External Links for MIR96 Gene

HapMap Linkage Disequilibrium report
Human Gene Mutation Database (HGMD)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MIR96 Gene

Disorders for MIR96 Gene

(1) OMIM Diseases for MIR96 Gene (611606)

genes like me logo Genes that share disorders with MIR96: view

No data available for UniProtKB/Swiss-Prot , University of Copenhagen DISEASES , Novoseek inferred disease relationships , Genatlas and External Links for MIR96 Gene

Publications for MIR96 Gene

  1. Mutations in the seed region of human miR-96 are responsible for nonsyndromic progressive hearing loss. (PMID: 19363479) MencA-a A. … Moreno-Pelayo M.A. (Nat. Genet. 2009) 2 3
  2. A novel locus for autosomal dominant nonsyndromic hearing loss, DFNA50, maps to chromosome 7q32 between the DFNB17 and DFNB13 deafness loci. (PMID: 14757864) Modamio-HA … Moreno F. (J. Med. Genet. 2004) 2 3
  3. MicroRNA (miRNA) transcriptome of mouse retina and identification of a sensory organ-specific miRNA cluster. (PMID: 17597072) Xu S. … Valle D. (J. Biol. Chem. 2007) 3
  4. miRNPs: a novel class of ribonucleoproteins containing numerous microRNAs. (PMID: 11914277) Mourelatos Z. … Dreyfuss G. (Genes Dev. 2002) 3
  5. miRBase: microRNA sequences, targets and gene nomenclature. (PMID: 16381832) Griffiths-Jones S. … Enright A.J. (Nucleic Acids Res. 2006) 3

Products for MIR96 Gene

Sources for MIR96 Gene

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