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Aliases for MIR96 Gene

Subcategory (RNA class) for MIR96 Gene

miRNA

Quality Score for this RNA gene is

13

Aliases for MIR96 Gene

  • MicroRNA 96 2 3 5
  • Deafness, Autosomal Dominant 50 2
  • Hsa-Mir-96 3
  • MiRNA96 3
  • MiR-96 3
  • DFNA50 3
  • MIRN96 3

External Ids for MIR96 Gene

Previous HGNC Symbols for MIR96 Gene

  • MIRN96
  • DFNA50

Previous GeneCards Identifiers for MIR96 Gene

  • GC07M129203
  • GC07M129414

Summaries for MIR96 Gene

Entrez Gene Summary for MIR96 Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR96 Gene

MIR96 (MicroRNA 96) is an RNA Gene, and is affiliated with the miRNA class. Diseases associated with MIR96 include Deafness, Autosomal Dominant 50 and Dfna50 Nonsyndromic Hearing Loss And Deafness. Among its related pathways are MicroRNAs in cancer.

No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MIR96 Gene

Genomics for MIR96 Gene

Genomic Location for MIR96 Gene

Chromosome:
7
Start:
129,774,692 bp from pter
End:
129,774,769 bp from pter
Size:
78 bases
Orientation:
Minus strand

Genomic View for MIR96 Gene

Genes around MIR96 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MIR96 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR96 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR96 Gene

ORGUL Member Location for MIR96 Gene

ORGUL Member Location for MIR96 gene

No data available for Regulatory Elements for MIR96 Gene

Proteins for MIR96 Gene

Post-translational modifications for MIR96 Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR96 Gene

Domains & Families for MIR96 Gene

Gene Families for MIR96 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with MIR96: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for MIR96 Gene

Function for MIR96 Gene

Human Phenotype Ontology for MIR96 Gene

HPO Id HPO Name Alternative Ids Definition Synonyms

Animal Model Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR96 Gene

Localization for MIR96 Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS and Gene Ontology (GO) - Cellular Components for MIR96 Gene

Pathways & Interactions for MIR96 Gene

SuperPathways for MIR96 Gene

SuperPathway Contained pathways
1 MicroRNAs in cancer
genes like me logo Genes that share pathways with MIR96: view

Pathways by source for MIR96 Gene

1 KEGG pathway for MIR96 Gene

Interacting Proteins for MIR96 Gene

Gene Ontology (GO) - Biological Process for MIR96 Gene

None

No data available for SIGNOR curated interactions for MIR96 Gene

Drugs & Compounds for MIR96 Gene

No Compound Related Data Available

Transcripts for MIR96 Gene

mRNA/cDNA for MIR96 Gene

(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Alternative Splicing Database (ASD) splice patterns (SP) for MIR96 Gene

No ASD Table

Relevant External Links for MIR96 Gene

GeneLoc Exon Structure for
MIR96
ECgene alternative splicing isoforms for
MIR96

Expression for MIR96 Gene

NURSA nuclear receptor signaling pathways regulating expression of MIR96 Gene:

MIR96

Phenotype-based relationships between genes and organs from Gene ORGANizer for MIR96 Gene

Germ Layers:
  • ectoderm
  • mesoderm
Systems:
  • nervous
Organs:
Head and neck:
  • brain
  • cerebellum
  • cranial nerve
  • ear
  • head
  • inner ear
  • middle ear
  • outer ear
Thorax:
  • heart
  • heart valve
Limb:
  • forearm
General:
  • peripheral nerve
  • peripheral nervous system
No Expression Related Data Available

No data available for mRNA expression in normal human tissues , mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Evidence on tissue expression from TISSUES for MIR96 Gene

Orthologs for MIR96 Gene

This gene was present in the common ancestor of chordates.

Orthologs for MIR96 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ptr-mir-96 35
  • 100 (a)
OneToOne
dog
(Canis familiaris)
Mammalia cfa-mir-96 35
  • 88 (a)
OneToOne
cow
(Bos Taurus)
Mammalia bta-mir-96 35
  • 75 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia mdo-mir-96 35
  • 75 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Mir96 35
  • 72 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia oan-mir-96 35
  • 67 (a)
OneToOne
chicken
(Gallus gallus)
Aves -- 35
  • 63 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii dre-mir-96 35
  • 50 (a)
OneToOne
Species where no ortholog for MIR96 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for MIR96 Gene

ENSEMBL:
Gene Tree for MIR96 (if available)
TreeFam:
Gene Tree for MIR96 (if available)

Paralogs for MIR96 Gene

No data available for Paralogs for MIR96 Gene

Variants for MIR96 Gene

Sequence variations from dbSNP and Humsavar for MIR96 Gene

SNP ID Clin Chr 07 pos Sequence Context AA Info Type
rs587776522 Pathogenic 129,774,757(+) TAGTG(C/T)CAAAA nc-transcript-variant, downstream-variant-500B
rs587776523 Pathogenic 129,774,756(+) CTAGT(G/T)CCAAA nc-transcript-variant, downstream-variant-500B
rs72631833 Likely benign 129,774,964(-) ACTGT(G/T)AACAG nc-transcript-variant, upstream-variant-2KB
rs73159662 Likely benign 129,774,728(+) AGAGC(A/G)GAGAG nc-transcript-variant, downstream-variant-500B
rs41274239 Benign 129,774,734(+) GAGAG(A/G)CACAA nc-transcript-variant, downstream-variant-500B

Structural Variations from Database of Genomic Variants (DGV) for MIR96 Gene

Variant ID Type Subtype PubMed ID
esv23078 CNV gain 19812545
nsv464721 CNV loss 19166990
nsv516024 CNV gain+loss 19592680
nsv608420 CNV loss 21841781
nsv949946 CNV deletion 24416366

Relevant External Links for MIR96 Gene

Human Gene Mutation Database (HGMD)
MIR96
SNPedia medical, phenotypic, and genealogical associations of SNPs for
MIR96

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Variation tolerance for MIR96 Gene

Disorders for MIR96 Gene

MalaCards: The human disease database

(4) MalaCards diseases for MIR96 Gene - From: OMIM, ClinVar, GeneTests, Orphanet, and GeneCards

Disorder Aliases PubMed IDs
deafness, autosomal dominant 50
  • autosomal dominant nonsyndromic deafness 50
dfna50 nonsyndromic hearing loss and deafness
  • dfna 50
autosomal dominant non-syndromic sensorineural deafness type dfna
  • autosomal dominant isolated neurosensory deafness type dfna
nonsyndromic hearing loss and deafness, autosomal dominant
- elite association - COSMIC cancer census association via MalaCards
Search MIR96 in MalaCards View complete list of genes associated with diseases

Relevant External Links for MIR96

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
MIR96
genes like me logo Genes that share disorders with MIR96: view

No data available for UniProtKB/Swiss-Prot and Genatlas for MIR96 Gene

Publications for MIR96 Gene

  1. Mutations in the seed region of human miR-96 are responsible for nonsyndromic progressive hearing loss. (PMID: 19363479) MencA-a A. … Moreno-Pelayo M.A. (Nat. Genet. 2009) 2 3 64
  2. A novel locus for autosomal dominant nonsyndromic hearing loss, DFNA50, maps to chromosome 7q32 between the DFNB17 and DFNB13 deafness loci. (PMID: 14757864) Modamio-HA … Moreno F. (J. Med. Genet. 2004) 2 3 64
  3. The miR-200 family and the miR-183~96~182 cluster target Foxf2 to inhibit invasion and metastasis in lung cancers. (PMID: 25798833) Kundu S.T. … Gibbons D.L. (Oncogene 2016) 3 64
  4. OncomiR miR-96 and miR-182 promote cell proliferation and invasion through targeting ephrinA5 in hepatocellular carcinoma. (PMID: 25663355) Wang T.H. … Chen T.C. (Mol. Carcinog. 2016) 3 64
  5. High expression of microRNA-183/182/96 cluster as a prognostic biomarker for breast cancer. (PMID: 27071841) Song C. … Xie X. (Sci Rep 2016) 3 64

Products for MIR96 Gene

Sources for MIR96 Gene

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