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Aliases for MIR943 Gene

Subcategory (RNA class) for MIR943 Gene

miRNA

Quality Score for this RNA gene is

3

Aliases for MIR943 Gene

  • MicroRNA 943 2 3
  • NELFA 4 5
  • Wolf-Hirschhorn Syndrome Candidate 2 Protein 4
  • Negative Elongation Factor Complex Member A 5
  • Hsa-Mir-943 3
  • MIRN943 3
  • NELF-A 4
  • WHSC2 4

External Ids for MIR943 Gene

Previous HGNC Symbols for MIR943 Gene

  • MIRN943

Previous GeneCards Identifiers for MIR943 Gene

  • GC04M001959

Summaries for MIR943 Gene

Entrez Gene Summary for MIR943 Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR943 Gene

MIR943 (MicroRNA 943) is an RNA Gene, and is affiliated with the miRNA class. Diseases associated with MIR943 include Wolf-Hirschhorn Syndrome. Among its related pathways are HIV Life Cycle and Gene Expression.

UniProtKB/Swiss-Prot for MIR943 Gene

  • Essential component of the NELF complex, a complex that negatively regulates the elongation of transcription by RNA polymerase II. The NELF complex, which acts via an association with the DSIF complex and causes transcriptional pausing, is counteracted by the P-TEFb kinase complex. Probably required to interact with the RNA polymerase II complex.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MIR943 Gene

Genomics for MIR943 Gene

Regulatory Elements for MIR943 Gene

Enhancers for MIR943 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH04F001512 1.1 Ensembl ENCODE 45.5 +528.8 528840 1.6 ZNF76 YBX1 NFXL1 RAD21 GLIS2 ZNF302 ZNF416 ZNF207 ZNF548 RCOR1 HAUS3 MIR943 CTBP1-AS2 CRIPAK ENSG00000272588 LOC100129917 IDUA PDE6B ENSG00000270195 GC04M001514
GH04F001938 0.5 Ensembl ENCODE 23.4 +101.9 101940 2.2 INSM2 FEZF1 ZNF2 ZNF335 ZNF366 SCRT2 FOS ZNF280D TSHZ1 ZEB2 MIR943 HAUS3 CRIPAK NELFA ENSG00000254094 LETM1 C4orf48 PIR46454 GC04P001890
GH04F002243 0.4 ENCODE 21.8 -202.1 -202122 1.1 HDGF ARNT ARID4B NFXL1 ZNF48 ZNF2 RAD21 ZEB1 RARA GLIS2 HAUS3 MIR943 CRIPAK CTBP1-AS2 NOP14-AS1 ENSG00000270195 PIR41429 POLN
GH04F002255 1 Ensembl ENCODE 15.9 -217.4 -217419 8.1 ATF1 PKNOX1 CREB3L1 ARID4B SIN3A DMAP1 ZNF48 YY1 GTF3C2 GLIS2 HAUS3 CRIPAK MIR943 ENSG00000254094 MXD4 ENSG00000244459 SLBP GC04M002217 MIR4800
GH04F001808 0.6 ENCODE 15.9 +232.2 232161 1.6 PKNOX1 ARID4B ZNF48 GTF3C2 GLIS2 CBX5 ZNF143 PAF1 ZNF263 SP5 CRIPAK MIR943 HAUS3 LETM1 ENSG00000254094 GC04M001809 GC04P001802
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around MIR943 on UCSC Golden Path with GeneCards custom track

Genomic Location for MIR943 Gene

Chromosome:
4
Start:
1,982,714 bp from pter
End:
2,041,903 bp from pter
Size:
59,190 bases
Orientation:
Minus strand

Genomic View for MIR943 Gene

Genes around MIR943 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MIR943 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR943 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR943 Gene

Proteins for MIR943 Gene

  • Protein details for MIR943 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9H3P2-NELFA_HUMAN
    Recommended name:
    Negative elongation factor A
    Protein Accession:
    Q9H3P2
    Secondary Accessions:
    • A2A2T1
    • O95392

    Protein attributes for MIR943 Gene

    Size:
    528 amino acids
    Molecular mass:
    57277 Da
    Quaternary structure:
    • The NELF complex is composed of NELFA, NELFB, NELFCD (isoform NELF-C or isoform NELF-D) and NELFE. Interacts with the RNA polymerase II complex when it is not phosphorylated by P-TEFb.
    • The NELF complex is composed of NELFA, NELFB, NELFCD (isoform NELF-C or isoform NELF-D) and NELFE. Interacts with the RNA polymerase II complex when it is not phosphorylated by P-TEFb.
    SequenceCaution:
    • Sequence=AAC72982.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=BAG54283.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305}; Sequence=CAM15219.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305}; Sequence=EAW82546.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for MIR943 Gene

    Alternative splice isoforms for MIR943 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for MIR943 Gene

Post-translational modifications for MIR943 Gene

  • Ubiquitination at Lys 371
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for MIR943 Gene

Domains & Families for MIR943 Gene

Gene Families for MIR943 Gene

Protein Domains for MIR943 Gene

InterPro:
ProtoNet:

Graphical View of Domain Structure for InterPro Entry

Q9H3P2

UniProtKB/Swiss-Prot:

NELFA_HUMAN :
  • The HDAg-like domain is essential for transcriptional repression, and mediates the interaction with the RNA polymerase II complex.
  • Belongs to the NELF-A family.
Domain:
  • The HDAg-like domain is essential for transcriptional repression, and mediates the interaction with the RNA polymerase II complex.
  • Contains 1 HDAg-like domain.
Family:
  • Belongs to the NELF-A family.
genes like me logo Genes that share domains with MIR943: view

No data available for Suggested Antigen Peptide Sequences for MIR943 Gene

Function for MIR943 Gene

Molecular function for MIR943 Gene

UniProtKB/Swiss-Prot Function:
Essential component of the NELF complex, a complex that negatively regulates the elongation of transcription by RNA polymerase II. The NELF complex, which acts via an association with the DSIF complex and causes transcriptional pausing, is counteracted by the P-TEFb kinase complex. Probably required to interact with the RNA polymerase II complex.

Animal Model Products

miRNA Products

Clone Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR943 Gene

Localization for MIR943 Gene

Subcellular locations from UniProtKB/Swiss-Prot for MIR943 Gene

Gene Ontology (GO) - Cellular Components for MIR943 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
GO:0005654 nucleoplasm IDA --
GO:0005737 cytoplasm IDA --
GO:0032021 NELF complex IEA --
genes like me logo Genes that share ontologies with MIR943: view

No data available for Subcellular locations from COMPARTMENTS for MIR943 Gene

Pathways & Interactions for MIR943 Gene

genes like me logo Genes that share pathways with MIR943: view

Gene Ontology (GO) - Biological Process for MIR943 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0006366 transcription from RNA polymerase II promoter TAS --
GO:0006368 transcription elongation from RNA polymerase II promoter TAS --
GO:0007275 multicellular organism development TAS --
genes like me logo Genes that share ontologies with MIR943: view

No data available for SIGNOR curated interactions for MIR943 Gene

Transcripts for MIR943 Gene

mRNA/cDNA for MIR943 Gene

(17) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Alternative Splicing Database (ASD) splice patterns (SP) for MIR943 Gene

No ASD Table

Relevant External Links for MIR943 Gene

GeneLoc Exon Structure for
MIR943
ECgene alternative splicing isoforms for
MIR943

Expression for MIR943 Gene

mRNA expression in normal human tissues for MIR943 Gene

NURSA nuclear receptor signaling pathways regulating expression of MIR943 Gene:

MIR943

mRNA Expression by UniProt/SwissProt for MIR943 Gene:

Q9H3P2-NELFA_HUMAN
Tissue specificity: Ubiquitous. Expressed in heart, brain, placenta, liver, skeletal muscle, kidney and pancreas. Expressed at lower level in adult lung. Expressed in fetal brain, lung, liver and kidney.
genes like me logo Genes that share expression patterns with MIR943: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression and Protein tissue co-expression partners for MIR943 Gene

Orthologs for MIR943 Gene

This gene was present in the common ancestor of animals.

Orthologs for MIR943 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia NELFA 35
  • 100 (a)
OneToOne
dog
(Canis familiaris)
Mammalia NELFA 35
  • 95 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Nelfa 35
  • 95 (a)
OneToOne
cow
(Bos Taurus)
Mammalia WHSC2 35
  • 92 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia NELFA 35
  • 83 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia NELFA 35
  • 76 (a)
OneToOne
chicken
(Gallus gallus)
Aves WHSC2 35
  • 85 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia NELFA 35
  • 81 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii nelfa 35
  • 79 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta Nelf-A 35
  • 14 (a)
OneToOne
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 39 (a)
OneToOne
Species where no ortholog for MIR943 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for MIR943 Gene

ENSEMBL:
Gene Tree for MIR943 (if available)
TreeFam:
Gene Tree for MIR943 (if available)

Paralogs for MIR943 Gene

No data available for Paralogs for MIR943 Gene

Variants for MIR943 Gene

Sequence variations from dbSNP and Humsavar for MIR943 Gene

SNP ID Clin Chr 04 pos Sequence Context AA Info Type
rs1077020 -- 1,986,466(+) CGAGC(C/T)CAGAA intron-variant, nc-transcript-variant
rs112825875 -- 1,986,848(+) GCGTG(C/T)GTGGC intron-variant, upstream-variant-2KB
rs114173851 -- 1,987,451(+) CGGGG(C/G)GCACA intron-variant, upstream-variant-2KB
rs117150526 -- 1,986,623(+) AGACA(C/G)CGGCA intron-variant, upstream-variant-2KB
rs139008938 -- 1,987,275(+) CAGGA(C/T)GACAC intron-variant, upstream-variant-2KB

Relevant External Links for MIR943 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MIR943

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Structural Variations from Database of Genomic Variants (DGV) and Variation tolerance for MIR943 Gene

Disorders for MIR943 Gene

MalaCards: The human disease database

(1) MalaCards diseases for MIR943 Gene - From: GeneCards

Disorder Aliases PubMed IDs
wolf-hirschhorn syndrome
  • 4p deletion syndrome
- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for MIR943

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
MIR943
genes like me logo Genes that share disorders with MIR943: view

No data available for UniProtKB/Swiss-Prot and Genatlas for MIR943 Gene

Publications for MIR943 Gene

  1. An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome. (PMID: 24275569) Bian Y. … Zou H. (J. Proteomics 2014) 4 64
  2. Toward a comprehensive characterization of a human cancer cell phosphoproteome. (PMID: 23186163) Zhou H. … Mohammed S. (J. Proteome Res. 2013) 4 64
  3. Initial characterization of the human central proteome. (PMID: 21269460) Burkard T.R. … Colinge J. (BMC Syst. Biol. 2011) 4 64
  4. Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis. (PMID: 20068231) Olsen J.V. … Mann M. (Sci. Signal. 2010) 4 64
  5. Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach. (PMID: 19413330) Gauci S. … Mohammed S. (Anal. Chem. 2009) 4 64

Products for MIR943 Gene

Sources for MIR943 Gene

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